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Articles 1 - 2 of 2
Full-Text Articles in Biological Factors
Environmental Modulation Of Jak3-Mediated Immune Dysregulation In Alopecia Areata, Rylee Davis
Environmental Modulation Of Jak3-Mediated Immune Dysregulation In Alopecia Areata, Rylee Davis
Sustainability Conference
Alopecia areata (AA) is an autoimmune disorder characterized by non-scarring hair loss resulting from T-cell–driven destruction of hair follicles. Central to this process is the dysregulation of Janus kinase 3 (JAK3), a non-receptor tyrosine kinase selectively expressed in hematopoietic cells that mediates γc cytokine receptor signaling. Aberrant JAK3 activity disrupts follicular immune privilege and amplifies pro-inflammatory cytokine cascades, sustaining a chronic autoimmune state. While genetic susceptibility contributes to JAK3 overactivation, converging evidence highlights a pivotal role for environmental exposures in modulating its expression and signaling dynamics. In this framework, we focus on urban air pollutants like particularly fine particulate matter, …
Biological Warfare As Psychological Warfare, Ibpp Editor
Biological Warfare As Psychological Warfare, Ibpp Editor
International Bulletin of Political Psychology
This article describes the psychological benefits of an offensive biological warfare program