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Articles 121 - 123 of 123
Full-Text Articles in Chemicals and Drugs
Dual Mechanism Analgesia-Enhancing Agents, Shawquia Elithia Young
Dual Mechanism Analgesia-Enhancing Agents, Shawquia Elithia Young
Theses and Dissertations
Currently, there is an increasing need for novel analgesics that are potent but lack undesired side effects. Recent studies have shown that both 5-HT3 receptors and α2B- adrenoceptors play a role in antinociception. MD-354, N-(3-chlorophenyl)guanidine, has a high-affinity both for 5-HT3 and α2B- adrenoceptors and could be viewed as the first example of a rather selective 5-HT3/α2B- adrenoceptor ligand. MD-354, inactive by itself, potentiates the antinociceptive effects of an inactive dose of clonidine in the mouse tail- flick assay. An attempt to determine the underlying mechanism of this potentiating effect was the purpose of the present investigation. The studies focused …
Stability Study Of Phoslactomycin B And Analysis Of Degradation Products, Choudhuri Suparna Das
Stability Study Of Phoslactomycin B And Analysis Of Degradation Products, Choudhuri Suparna Das
Theses and Dissertations
Phoslactomycin B (PLM-B), a potent and selective inhibitor of serine threonine phosphatase is of interest for its antitumor, antifungal and antiviral activity. The objective of this study was to evaluate the stability of phoslactomycin B at various pH and temperature conditions. Phoslactomycin B was produced from the mutant strain NP1 of Streptomyces sp.HK-803 and was purified by semi-preparative HPLC . A study of PLM-B degradation was carried out in the pH range of 2-10 at 30ºC and 50°C using HPLC. The PLM-B decomposition was observed to exhibit a U-shaped pH profile and demonstrated both acid and base-catalyzed decomposition. The decomposition …
New Antimuscarinic Agents For Improved Treatment Of Poisoning By Cholinesterase Inhibitors, Robert Lee Hudkins
New Antimuscarinic Agents For Improved Treatment Of Poisoning By Cholinesterase Inhibitors, Robert Lee Hudkins
Theses and Dissertations
Poisoning by organophosphate cholinesterase inhibitors results in a rapid rise in acetylcholine (ACh) in the synapse and many pronounced pharmacological effects in numerous tissues in the body. The treatment for organophosphorus poisoning involves administration of a cholinesterase—reactivating oxime to restore the activity of the cholinesterase and an antimuscarinic agent to block the response to the excess ACh. Presently atropine is the standard antimuscarinic agent used clinically as an antidote. This research was directed toward finding an antimuscarinic agent better than atropine as an antidote.
Since caramiphen and aprophen have been reported to be effective antidotes we synthesized numerous structural variations …