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Full-Text Articles in Biomedical Informatics
Population Amalgamation And Genetic Variation: Observations On Artificially Agglomerated Tribal Populations Of Central And South America, R Chakraborty, P E Smouse, J V Neel
Population Amalgamation And Genetic Variation: Observations On Artificially Agglomerated Tribal Populations Of Central And South America, R Chakraborty, P E Smouse, J V Neel
Faculty, Staff and Student Publications
The interpretation of data on genetic variation with regard to the relative roles of different evolutionary factors that produce and maintain genetic variation depends critically on our assumptions concerning effective population size and the level of migration between neighboring populations. In humans, recent population growth and movements of specific ethnic groups across wide geographic areas mean that any theory based on assumptions of constant population size and absence of substructure is generally untenable. We examine the effects of population subdivision on the pattern of protein genetic variation in a total sample drawn from an artificial agglomerate of 12 tribal populations …
Characterization Of The K Variant Of Encephalomyocarditis Virus, Delie Roselyn Cerutis
Characterization Of The K Variant Of Encephalomyocarditis Virus, Delie Roselyn Cerutis
Biomedical Sciences Theses and Dissertations
Serologically identical variants of encephalomyocarditis (EMC) virus produce different disease syndromes in mice. For instance, in ICR Swiss male mice, the B variant (EMC-B) produces no overt illness, EMC-MM produces death accompanied by eevere neurological signs, and EMC-0 destroys beta cells, thus producing a disease syndrome that resembles insulin-dependent diabetes mellitus. These apparently identical viruses provide excellent models to investigate the molecular basis of disease. Recently, we isolated a lethal variant (EMC-K) from the EMC-B virus stock and compared its characteristics to three other EMC virus variants, EMC-B, D, and MM. The present study was done to determine (i) the …