Biomedical Informatics Commons^™

Editorial: Methods And Applications Of Tumour Metabolic Imaging In The Preclinical And Clinical Setting, Liangjie Lin, Zhiliang Wei, Jing Wang, Nian Wang

Faculty, Staff and Student Publications

No abstract provided.

Canadian Spine Society: 24th Annual Scientific Conference, Wednesday, February 28 - Saturday, March 2, Fairmont Chateau Whistler, Whistler, Bc, Canada, Antoine Dionne, Majeed Al-Zakri, Hubert Labelle, Julie Joncas, Stefan Parent, Jean-Marc Mac-Thiong, Firoz Miyanji, Baron Lonner, Ali Eren, Patrick Cahill, Peter Newton, Jennifer A Dermott, Liisa Jaakkimainen, Teresa To, Maryse Bouchard, Andrew Howard, David E Lebel, Sarah Hardy, Armaan K Malhotra, Jennifer Dermott, Dilani Thevarajah, Karen D A Mathias, Samuel Yoon, Rajendra Sakhrekar, Dorothy J Kim, Ayesha Hadi, Andrea Doria, Aya Mitani, David Lebel, Karen Mathias, Tracey Bastrom, Amer Samdani, Marjolaine Roy-Beaudry, Marie Beauséjour, Rachelle Imbeault, Justin Dufresne, Jessica Romeo, Holly Livock, Kevin Smit, James Jarvis, Andrew Tice, Vivien K Chan, Robert Cho, Selina Poon, David L Skaggs, Geoffrey K Shumilak, Brett Rocos, Juan P Sardi, Anastasios Charalampidis, Jeff Gum, Stephen J Lewis, Peter S Tretiakov, Oluwatobi Onafowokan, Jamshaid Mir, Ankita Das, Tyler Williamson, Pooja Dave, Bailey Imbo, Jordan Lebovic, Pawel Jankowski, Peter G Passias, Stephen Lewis, Yousef Aljamaan, Lawrence G Lenke, Justin Smith, Vishal P Varshney, Ramesh Sahjpaul, Scott Paquette, Jill Osborn, Rémi Pelletier-Roy, Michael Asmussen, Manjot Birk, Taryn Ludwig, Fred Nicholls, Ariel Zohar, Janneke Loomans, Ferran Pellise, Justin S Smith, So Kato, Zeeshan Sardar, Lawrence Lenke, Aazad Abbas, Jay Toor, Gurjovan Sahi, Dusan Kovacevic, Johnathan Lex, Raja Rampersaud, Anthony V Perruccio, Nizar Mahomed, Mayilee Canizares, Maroun Rizkallah, Michel Alexandre Lebreton, Ghassan Boubez, Jesse Shen, Fidaa Alshakfa, Yousef Kamel, Galil Osman, Zhi Wang, Nikolaus Koegl, Brandon Herrington, Renan R Fernandes, Jennifer C Urquhart, Yoga R Rampersaud, Chris S Bailey, Ramtin Hakimjavadi, Tinghua Zhang, Zachary Devries, Eugene K Wai, Stephen P Kingwell, Alexandra Stratton, Eve Tsai, Philippe Phan, Noah Fine, Laura Stone, Mohit Kapoor, Alexandre Chênevert, Sonia Bédard, Greg Mcintosh, Julien Goulet, Jérome Couture, Csorn Investigators, Bernard Larue, Brent Rosenstein, Meaghan Rye, Alexa Roussac, Neda Naghdi, Luciana G Macedo, James Elliott, Richard Demont, Michael H Weber, Véronique Pepin, Geoffrey Dover, Maryse Fortin, Edisond Florial, Aditya Raj, Prarthan Amin, Yoga Raja Rampersaud, Abdullah A S M Alduwaisan, Kim Phan, Stephen Kingwell, Eugene Wai, Jeffrey Hebert, Sarah Nowell, Niels Wedderkopp, Amanda Vandewint, Neil Manson, Edward Abraham, Christopher Small, Najmedden Attabib, Erin Bigney, Michael Craig, Abdul Al-Shawwa, Kalum Ost, Saswati Tripathy, Nathan Evaniew, Bradley Jacobs, David Cadotte, Nicolas Dea, Jefferson R Wilson, Christopher S Bailey, Y Raja Rampersaud, W Bradley Jacobs, Philippe Phan Phan, Andrew Nataraj, David W Cadotte, Kenneth C Thomas, Jerome Paquet, Sean D Christie, Hamilton Hall, Charles G Fisher, Eva Y Liu, Amit R L Persad, Nathan Baron, Daryl Fourney, Husain Shakil, Jingyi Huang, Nader Fallah, Charlotte Dandurand, Csorn Investigators, Thamer Alfawaz, Tinghua Zhang, Alexandra Stratton, Eve Tsai, Eugene Wai, Stephen Kingwell, Zhi Wang, Philippe Phan, Csorn Investigators, Julien Francisco Zaldivar-Jolissaint, Raphaële Charest-Morin, Greg Mcintosh, Michael G Fehlings, Karlo M Pedro, Mohammed Ali Alvi, Jessica C W Wang, Raphaële Charest-Morin, Nicolas Dea, Charles Fisher, Marcel Dvorak, Brian Kwon, Tamir Ailon, Scott Paquette, John Street, Charlotte Dandurand, Rohail Mumtaz, Khaled Skaik, Eugene K Wai, Stephen Kingwell, Alexandra Stratton, Eve Tsai, Philippe Tran Nhut Phan, Zhi Wang, Csorn Investigators, Ragavan Manoharan, Greg Mcintosh, Yoga R Rampersaud, Jenna Smith-Forrester, Joanne E Douglas, Evan Nemeth, Jacob Alant, Sean Barry, Andrew Glennie, William Oxner, Lutz Weise, Sean Christie, Eva Y Liu, Amit R L Persad, Sabahat Saeed, Patrick Toyota, Jack Su, Braeden Newton, Nicole Coote, Daryl Fourney, Maria S Rachevits, Helen Razmjou, Susan Robarts, Albert Yee, Joel Finkelstein, Alysa Almojuela, Frederick Zeiler, Sarvesh Logsetty, Perry Dhaliwal, Mark Abdelnour, Yuxin Zhang, Eugene Wai, Stephen P Kingwell, Alexandra Stratton, Eve Tsai, Philippe T Phan, Csorn Investigators, Taylor A Smith, Christopher Small, Erin Bigney, Eden Richardson, Jillian Kearney, Neil Manson, Edward Abraham, Najmedden Attabib, Michael Bond, Stephan Dombrowski, Gwyneth Price, Jose Manuel García-Moreno, Jeffrey Hebert, Steven Qiu, Vithushan Surendran, Victoria Shi Emily Cheung, Sophie Ngana, Muhammad A Qureshi, Sunjay V Sharma, Markian Pahuta, Daipayan Guha, Ahmad Essa, Husain Shakil, Armaan Malhotra, James Byrne, Jetan Badhiwala, Eva Yuan, Yingshi He, Andrew Jack, Francois Mathieu, Jefferson R Wilson, Christopher D Witiw, Husain Shakil, Armaan K Malhotra, Eva Yuan, Christopher W Smith, Erin M Harrington, Rachel H Jaffe, Alick P Wang, Karim Ladha, Avery B Nathens, Jefferson R Wilson, Christopher D Witiw, Ryan V Sandarage, Ahmad Galuta, Eve C Tsai, Naama Rotem-Kohavi, Marcel F Dvorak, Jijie Xu, Nader Fallah, Zeina Waheed, Melody Chen, Nicolas Dea, Nathan Evaniew, Vanessa Noonan, Brian Kwon, Brian K Kwon, Toluyemi Malomo, Raphaële Charest-Morin, Scott Paquette, Tamir Ailon, Charlotte Dandurand, John Street, Charles G Fisher, Nicolas Dea, Manraj Heran, Marcel Dvorak, Rachael Jaffe, Peter Coyte, Brian Chan, Armaan Malhotra, Rebecca Hancock-Howard, Jefferson Wilson, Christopher Witiw, Newton Cho, Jordan Squair, Viviana Aureli, Nicholas James, Lea Bole-Feysot, Inssia Dewany, Nicolas Hankov, Laetitia Baud, Anna Leonhartsberger, Kristina Sveistyte, Michael Skinnider, Matthieu Gautier, Katia Galan, Maged Goubran, Jimmy Ravier, Frederic Merlos, Laura Batti, Stéphane Pagès, Nadia Bérard, Nadine Intering, Camille Varescon, Stefano Carda, Kay Bartholdi, Thomas Hutson, Claudia Kathe, Michael Hodara, Mark Anderson, Bogdan Draganski, Robin Demesmaeker, Leonie Asboth, Quentin Barraud, Jocelyne Bloch, Grégoire Courtine, Sean D Christie, Ryan Greene, Mustafa Nadi, Jacob Alant, Sean Barry, Andrew Glennie, Bill Oxner, Lutz Weise, Lisa Julien, Clara Lownie, Marcel F Dvorak, Cumhur F C Öner, Charlotte Dandurand, Alexander Joeris, Klaus Schnake, Mark Phillips, Alexander R Vaccaro, Richard Bransford, Eugen Cezar Popescu, Mohammed El-Sharkawi, Shanmuganathan Rajasekaran, Lorin M Benneker, Greg D Schroeder, Jin W Tee, John France, Jérôme Paquet, Richard Allen, William F Lavelle, Emiliano Vialle, Nicolas Dea, Antoine Dionne, David Magnuson, Andréane Richard-Denis, Yvan Petit, Francis Bernard, Dorothy Barthélémy, Jean-Marc Mac-Thiong, Lukas Grassner, Daniel Garcia-Ovejero, Evelyn Beyerer, Orpheus Mach, Iris Leister, Doris Maier, Ludwig Aigner, Angel Arevalo-Martin, Mark Alexander Maclean, Antoinette Charles, Miltiadis Georgiopoulos, Raphaële Charest-Morin, Rory Goodwin, Michael Weber, Emile Brouillard, Andréane Richard-Denis, Antoine Dionne, Ismail Laassassy, Paul Khoueir, Étienne Bourassa-Moreau, Gilles Maurais, Jean-Marc Mac-Thiong, Julien Francisco Zaldivar-Jolissaint, Nicolas Dea, Aysha Allard Brown, Kitty So, Neda Manouchehri, Megan Webster, Jay Ethridge, Audrey Warner, Avril Billingsley, Rochelle Newsome, Kirsten Bale, Andrew Yung, Mehara Seneviratne, Jimmy Cheng, Jing Wang, Shenani Basnayake, Femke Streijger, Manraj Heran, Piotr Kozlowski, Brian K Kwon, Jeff D Golan, Lior M Elkaim, Qais Alrashidi, Miltiadis Georgiopoulos, Oliver J Lasry, Drew A Bednar, Alyson Love, Soroush Nedaie, Pranjan Gandhi, Prarthan C Amin, Aditya Raj, Greg Mcintosh, Christopher J Neilsen, Ganesh Swamy, Raja Rampersaud, Amanda Vandewint, Y Raja Rampersaud, Jeffrey Hebert, Erin Bigney, Neil Manson, Najmedden Attabib, Chris Small, Eden Richardson, Jill Kearney, Edward Abraham, Raja Rampersaud, Aditya Raj, Nanadan Marathe, Greg Mcintosh, Manmeet Dhiman, Taylor J Bader, David Hart, Ganesh Swamy, Neil Duncan, Manmeet Dhiman, Taylor J Bader, Dragana Ponjevic, John R Matyas, David Hart, Ganesh Swamy, Neil Duncan, Connor P O'Brien, Jeffrey Hebert, Erin Bigney, Jillian Kearney, Eden Richardson, Edward Abraham, Neil Manson, Najmedden Attabib, Christopher Small, Luke Larochelle, Gabriella Rivas, James Lawrence, Robert Ravinsky, Dorothy Kim, Jennifer Dermott, Aya Mitani, Andrea Doria, Andrew Howard, David Lebel, Jennifer A Dermott, Lily S Switzer, Dorothy J Kim, David E Lebel, Chanelle Montpetit, Nicolas Vaillancourt, Brent Rosenstein, Maryse Fortin, Emma Nadler, Jennifer Dermott, Dorothy Kim, David E Lebel, Daniel Wolfe, Brent Rosenstein, Maryse Fortin, Daniel Wolfe, Geoffrey Dover, Mathieu Boily, Maryse Fortin, Husain Shakil, Armaan K Malhotra, Jetan H Badhiwala, Vishu Karthikeyan, Yingshi He, Michael G Fehlings, Arjun Sahgal, Nicolas Dea, Alex Kiss, Christopher D Witiw, Donald R Redelmeier, Jefferson R Wilson, Marco Pérez Caceres, Véronique Freire, Jesse Shen, Fidaa Al-Shakfa, Omer Ahmed, Zhi Wang, William Chu Kwan, Scott L Zuckerman, Charles G Fisher, Ilya Laufer, Dean Chou, John E O'Toole, Markus Schultheiss, Michael H Weber, Daniel M Sciubba, Markian Pahuta, John H Shin, Michael G Fehlings, Anne Versteeg, Matthew L Goodwin, Stefano Boriani, Chetan Bettegowda, Aron Lazary, Alessandro Gasbarrini, Jeremy J Reynolds, Jorrit-Jan Verlaan, Arjun Sahgal, Ziya L Gokaslan, Laurence D Rhines, Nicolas Dea, Van Tri Truong, The Khanh Dang, Galil Osman, Fidaa Al-Shakfa, Danielle Boule, Jesse Shen, Zhi Wang, Maroun Rizkallah, Ghassan Boubez, Jesse Shen, Philippe Phan, Fidaa Alshakfa, Danielle Boule, Celine Belguendouz, Rayane Kafi, Sung-Joo Yuh, Daniel Shedid, Zhi Wang, Zhi Wang, Jesse Shen, Ghassan Boubez, Fidaa Alshakfa, Daniele Boulé, Celine Belguendouz, Rayane Kafi, Philippe Phan, Daniel Shedid, Sung-Joo Yuh, Maroun Rizkallah, Yan Gabriel Morais David Silva, Luis Weber, Felipe Leão, Ahmad Essa, Armaan K Malhotra, Husain Shakil, James Byrne, Jetan Badhiwala, Avery B Nathens, Tej D Azad, Eva Yuan, Yingshi He, Andrew S Jack, Francois Mathieu, Jefferson R Wilson, Christopher D Witiw, Michael Craig, Nick Guenther, Jan Valosek, Maxime Bouthillier, Naga Karthik Enamundram, Naama Rotem-Kohavi, Suzanne Humphreys, Sean Christie, Michael Fehlings, Brian Kwon, Jean-Marc Mac-Thiong, Philippe Phan, Jerome Paquet, Mathieu Guay-Paquet, Julien Cohen-Adad, David Cadotte, Antoine Dionne, Jean-Marc Mac-Thiong, Heather Hong, Dilnur Kurban, Jijie Xu, Dorothy Barthélémy, Sean Christie, Daryl Fourney, Gary Linassi, Adalberto Loyola Sanchez, Jérôme Paquet, Vidya Sreenivasan, Andrea Townson, Eve C Tsai, Andréane Richard-Denis, William Chu Kwan, Pedram Laghaei, Harsh Kahlon, Tamir Ailon, Raphael Charest-Morin, Charlotte Dandurand, Scott Paquette, Nicholas Dea, John Street, Charles G Fisher, Marcel F Dvorak, Brian K Kwon, Jérémie Thibault, Antoine Dionne, Mohamed Al-Sofyani, Rémi Pelletier-Roy, Andréane Richard-Denis, Étienne Bourassa-Moreau, Jean-Marc Mac-Thiong, Maxime Bouthillier, Jan Valošek, Naga Karthik Enamundram, Mathieu Guay-Paquet, Nick Guenther, Naama Rotem-Kohavi, Suzanne Humphreys, Sean Christie, Michael Fehlings, Brian K Kwon, Jean Marc Mac-Thiong, Philippe Phan, David Cadotte, Julien Cohen-Adad, Luke Reda, Colton Kennedy, Stephanie Stefaniuk, Parvin Eftekhar, Larry Robinson, Cathy Craven, Jana Dengler, Colton Kennedy, Luke Reda, Stephanie Stefaniuk, Parvin Eftekhar, Larry Robinson, Cathy Craven, Jana Dengler, Maryam Rezaeezadeh Roukerd, Maitreya Patel, Eve Tsai, Ahmad Galuta, Sasi Jagadeesan, Ryan Vimukthie Sandarage, Philippe Phan, Wojtek Michalowski, William Van Woensel, Khushdeep Vig, Jillian Kazley, Abdul Arain, Gabriella Rivas, Robert Ravinsky, James Lawrence, Shaurya Gupta, Jibrahn Patel, Isaac Turkstra, Kirill Pustovetov, Victor Yang, W Bradley Jacobs, Gonzalo Mariscal, Christopher D Witiw, James S Harrop, Ahmed Essa, Christopher D Witiw, Gonzalo Mariscal, W Bradley Jacobs, James S Harrop, Ahmed Essa, Jin Tong Du, Ahmed Cherry, Rajesh Kumar, Nadia Jaber, Michael Fehlings, Albert Yee, Siril Teja Dukkipati, Mark Driscoll, Elizabeth Byers, Justin L Brown, Michelle Gallagher, James Sugar, Shannon Rockall, James Hektner, Scott Donia, John Chernesky, Vanessa K Noonan, Aaron A Varga, Flo Slomp, Emily Thiessen, Nataliya Lastivnyak, Linda Slater Maclean, Vanessa Ritchie, Aaron Hockley, Lutz M Weise, Christine Potvin, Peggy Flynn, Sean Christie, Isaac Turkstra, Bruno Oppermann, Marcelo Oppermann, Shaurya Gupta, Jibrahn Patel, Kirill Pustovetov, Kenneth Lee, Chaoliang Chen, Mohammadmahdi Rastgarjazi, Victor Yang, Sarah Hardy, Samuel Strantzas, Alison Anthony, Jennifer Dermott, Mike Vandenberk, Samer Hassan, David Lebel, Yan Gabriel Morais David Silva, Bernard Larue, Jerome Couture, Newton Pimenta, Jocelyn Blanchard, Alexandre Chenevert, Julien Goulet, Ryan Greene, Sean D Christie, Amanda Hall, Holly Etchegary, Alwalaa Althagafi, Jae Han, Ryan Greene, Sean Christie, Gwynedd Pickett, Christopher Witiw, James Harrop, W Bradley Jacobs, Gonzalo Mariscal, Ahmed Essa, W Bradley Jacobs, Gonzalo Mariscal, Christopher Witiw, James S Harrop, Ahmed Essa, Timothy Lasswell, Parham Rasoulinejad, Richard Hu, Chris Bailey, Fawaz Siddiqi, Abdulrahman Hamdoon, Mohamed Amin Soliman, Juhi Maraj, Deven Jhawar, Balraj Jhawar, Kirsten A Schuler, Lindsay D Orosz, Tarek Yamout, Brandon J Allen, Wondwossen T Lerebo, Rita T Roy, Thomas C Schuler, Christopher R Good, Colin M Haines, Ehsan Jazini, Kalum J Ost, Abdul Al-Shawwa, David Anderson, Nathan Evaniew, Bradley W Jacobs, Peter Lewkonia, Fred Nicholls, Paul T Salo, Kenneth C Thomas, Michael Yang, David Cadotte, Mohamed Sarraj, Nathasha Rajapaksege, Nicolas Dea, Nathan Evaniew, Greg Mcintosh, Markian Pahuta, Hani Nouran Alharbi, Khaled Skaik, Eugene K Wai, Stephen Kingwell, Alexandra Stratton, Eve Tsai, Philippe Tran Nhut Phan, Zhi Wang, Csorn Investigators, Julien Francisco Zaldivar-Jolissaint, Sara Gustafson, Ian Polyzois, Trevor Gascoyne, Michael Goytan, Drew Alexander Bednar, Mohamed Sarra, Brett Rocos, Juan P Sardi, Anastasios Charalampidis, Jeff Gum, Stephen J Lewis, Ravi Ghag, Samuel Kirk, Otis Shirley, Jeffrey Bone, Andrew Morrison, Firoz Miyanji, Amit Parekh, Ethan Sanders, Manjot Birk, Fred Nicholls, Kevin Smit, Holly Livock, Jessica Romeo, James Jarvis, Andrew Tice, Sofía Frank, Hubert Labelle, Stephan Parent, Soraya Barchi, Julie Joncas, Jean-Marc Mac-Thiong, Jérémie Thibault, Julie Joncas, Soraya Barchi, Stefan Parent, Marie Beausejour, Jean-Marc Mac-Thiong, Antoine Dionne, Jean-Marc Mac-Thiong, Stefan Parent, Jesse Shen, Julie Joncas, Soraya Barchi, Hubert Labelle, Manjot S Birk, Fred Nicholls, Rémi Pelletier-Roy, Ethan Sanders, Stephen Lewis, Yousef Aljamaan, Lawrence G Lenke, Justin Smith, Zeeshan Sardar, Elen Mullaj, David Lebel, Jennifer Dermott, Natasha Bath, Karen Mathias, Deepa Kattail, Ariel Zohar, Janneke Loomans, Ferran Pellise, Justin S Smith, So Kato, Zeeshan Sardar, Lawrence Lenke, Stephen J Lewis, Taylor J Bader, Manmeet Dhiman, David Hart, Neil Duncan, Paul Salo, Ganesh Swamy, Stephen Joel Lewis, Peyton Lloyd Lawrence, Justin Smith, Ferran Pellise, Zeeshan Sardar, Peyton Lloyd Lawrence, Stephen Joel Lewis, Justin Smith, Ferran Pellise, Zeeshan Sardar, Jordan J Levett, Abdulrhman Alnasser, Uri Barak, Lior M Elkaim, Thien Sa Hoang, Naif M Alotaibi, Daipayan Guha, Isaac L Moss, Alexander G Weil, Michael H Weber, Phillip De Muelenaere, Kashif Parvez, John Sun, Olivia C Iorio, Brent Rosenstein, Neda Naghdi, Maryse Fortin, Felicia Manocchio, Ran Ankory, Lisa Stallwood, Henry Ahn, Hamza Mahdi, Abdul Naeem, Deven Jhawar, Milad Moradi, Balraj Jhawar, Steven Qiu, Vithushan Surendran, Victoria Shi, Emily Cheung, Sophie Ngana, Muhammad A Qureshi, Sunjay V Sharma, Markian Pahuta, Daipayan Guha

Faculty, Staff and Student Publications

No abstract provided.

Deep Filtered Back Projection For Ct Reconstruction, X I Tan, Xuan Liu, Kai Xiang, Jing Wang, Shan Tan

Faculty, Staff and Student Publications

Filtered back projection (FBP) is a classic analytical algorithm for computed tomography (CT) reconstruction, with high computational efficiency. However, images reconstructed by FBP often suffer from excessive noise and artifacts. The original FBP algorithm uses a window function to smooth signals and a linear interpolation to estimate projection values at un-sampled locations. In this study, we propose a novel framework named DeepFBP in which an optimized filter and an optimized nonlinear interpolation operator are learned with neural networks. Specifically, the learned filter can be considered as the product of an optimized window function and the ramp filter, and the learned …

Correction: Preclinical Development Of 1b7/Cd3, A Novel Anti-Tslpr Bispecific Antibody That Targets Crlf2-Rearranged Ph-Like B-All, Ze Tian, Chunhua Shi, Guojun Yang, Jason K Allen, Qing Shi, Amin Al-Shami, Jill Wardell Olson, Melinda G Smith, Qing Chang, Jasbir Kaur, Junping You, Timothy E Lofton, Michelle A Gonzalez, Qi Zhang, Dongxing Zha, Sarah K Tasian, Nitin Jain, Marina Y Konopleva, Timothy Heffernan, Jeffrey J Molldrem

Faculty, Staff and Student Publications

No abstract provided.

Real-World Analysis Of Safety And Efficacy Of Car T-Cell Therapy In Lymphoma Patients With Decreased Kidney Function, Omar Mamlouk, Paolo Strati, Lei Feng, Ryan Sun, Amy Ayers, Raphael E Steiner, Ranjit Nair, Christopher Flowers, Jeremy L Ramdial, Neeraj Saini, Samer A Srour, Richard E Champlin, Partow Kebriaei, Loretta J Nastoupil, Maria A Rodriguez, Elizabeth J Shpall, Yago Nieto, Jason Westin, Sattva S Neelapu, Sreedhar Mandayam, Sairah Ahmed

Faculty, Staff and Student Publications

No abstract provided.

Meta-Analysis Of The Vmp-Like Sequences Of Lyme Disease Borrelia: Evidence For The Evolution Of An Elaborate Antigenic Variation System, Steven J Norris, Kalvis Brangulis

Faculty, Staff and Student Publications

VMP-like sequence (vls) antigenic variation systems are present in every Lyme disease Borrelia strain with complete genome sequences. The linear plasmid-encoded vls system consists of a single expression site (vlsE) and contiguous array(s) of silent cassettes that have ~90% identity with the central cassette region of the cognate vlsE gene; antigenic variation occurs through random, segmental, and unidirectional recombination of vls silent cassette sequences into the vlsE expression site. Automated annotation programs do not accurately recognize vls silent cassette sequences, so these regions are not correctly annotated in most genomic sequences. In this study, the vls …

Best Practice Recommendations For The Management Of Anxiety During The Pegvaliase Journey, Kendra J Bjoraker, Caroline Eggerding, Elisheva Ellenberg, Suzanne Hollander, Brittany M Holmes, Kristin Lindstrom, Markey Mcnutt, Suzanne Miller, Hope Northrup, Meaghan Rogers, Sarah Rose, Mia Scott, Soo Shim, Bridget Wardley, Leah Wessenberg, Deborah A Bilder

Faculty, Staff and Student Publications

Background: Pegvaliase, an enzyme substitution therapy, is a treatment option for phenylketonuria (PKU). Due to the neuropathophysiology and disease burden of PKU, individuals can experience baseline anxiety unrelated to pegvaliase therapy. In addition, there are aspects of pegvaliase therapy that may be anxiety-inducing for those considering or receiving treatment. The aim of this manuscript is to present best practice recommendations for the identification and management of anxiety symptoms that can occur along the pegvaliase journey.

Methods: A modified Delphi approach was used to seek consensus among a multidisciplinary panel of experts. To this end, an in-person meeting was held that …

Multicenter Randomized Controlled Trial Of Exercise In Aortic Dissection Survivors: Rationale, Design, And Initial Hemodynamic Data, Yasmin A Toy, Kayla N House, Leslie M Boyer, Jennifer L Mcnamara, Marion A Hofmann-Bowman, Kim A Eagle, Michelle S Lim, Alan C Braverman, Siddharth K Prakash

Faculty, Staff and Student Publications

Aims: There are currently no evidence-based guidelines for exercise after thoracic aortic dissection (TAD), leading to highly variable recommendations that frequently lead patients to restrict their physical activities. This multicenter randomized controlled trial was intended to evaluate the safety and efficacy of a moderate intensity guided exercise program for TAD survivors.

Methods: Participants were eligible if they had a Type A or Type B dissection at least 90 days before enrollment and could attend two in-person study visits. The guided exercise circuit consisted of six aerobic, isotonic, or isometric exercises that participants continued at home with virtual follow-up sessions. The …

Metformin In Conjunction With Stereotactic Radiotherapy For Early-Stage Non-Small Cell Lung Cancer: Long-Term Results Of A Prospective Phase Ii Clinical Trial, Molly K Tate, Mike Hernandez, Joe Y Chang, Steven H Lin, Zhongxing Liao, Suja M Koshy, Heath D Skinner, Stephen G Chun

Faculty, Staff and Student Publications

Background/aim: Non-small cell lung cancer (NSCLC) is increasingly detected in early stages and there is interest in improving outcomes with stereotactic body radiotherapy (SBRT). As metformin affects NSCLC signaling pathways, it might alter the metabolism of NSCLC treated with SBRT. This study investigated the long-term outcomes of a phase II clinical trial evaluating metformin in conjunction with SBRT for early-stage NSCLC.

Patients and methods: The trial evaluated patients with American Joint Commission on Cancer (AJCC) 7th edition Stage I-II, cT1-T2N0M0 NSCLC who were randomized 6:1 to receive metformin versus placebo in conjunction with SBRT. The outcomes analyzed included local failure …

Analysis Of B7-H4 Expression Across Salivary Gland Carcinomas Reveals Adenoid Cystic Carcinoma-Specific Prognostic Relevance, Juliana Mota Siqueira, Yoshitsugu Mitani, Camilla Oliveira Hoff, Flavia Bonini, Luana Guimaraes De Sousa, Mario L Marques-Piubelli, Anurag Purushothaman, Mutsumi Mitani, Hui Dai, Shiaw-Yih Lin, Michael T Spiotto, Ehab Y Hanna, Daniel J Mcgrail, Adel K El-Naggar, Renata Ferrarotto

Faculty, Staff and Student Publications

B7-H4 (VTCN1), a member of the B7 family, is overexpressed in several types of cancer. Here we investigated the pattern of expression of B7-H4 in salivary gland carcinomas (SGC) and assessed its potential as a prognostic marker and therapeutic target. Immunohistochemistry (IHC) analyses were performed in a cohort of 340 patient tumors, composed of 124 adenoid cystic carcinomas (ACC), 107 salivary duct carcinomas (SDC), 64 acinic cell carcinomas, 36 mucoepidermoid carcinomas (MEC), 9 secretory carcinomas (SC), as well as 20 normal salivary glands (controls). B7-H4 expression was scored and categorized into negative (< 5% expression of any intensity), low (5%-70% expression of any intensity or >70% with weak intensity), or high ( …

Predicting Suicidality In Late-Life Depression By 3d Convolutional Neural Network And Cross-Sample Entropy Analysis Of Resting-State Fmri, Chemin Lin, Chih-Mao Huang, Wei Chang, You-Xun Chang, Ho-Ling Liu, Shu-Hang Ng, Huang-Li Lin, Tatia Mei-Chun Lee, Shwu-Hua Lee, Shun-Chi Wu

Faculty, Staff and Student Publications

Background: Predicting suicide is a pressing issue among older adults; however, predicting its risk is difficult. Capitalizing on the recent development of machine learning, considerable progress has been made in predicting complex behavior such as suicide. As depression remained the strongest risk for suicide, we aimed to apply deep learning algorithms to identify suicidality in a group with late-life depression (LLD).

Methods: We enrolled 83 patients with LLD, 35 of which were non-suicidal and 48 were suicidal, including 26 with only suicidal ideation and 22 with past suicide attempts, for resting-state functional magnetic resonance imaging (MRI). Cross-sample entropy (CSE) analysis …

A Milestone In Epithelial-Mesenchymal Transition, Yutong Sun, Li Ma

Faculty, Staff and Student Publications

No abstract provided.

A Reinforcement Learning (Rl)-Motivated Simulation Framework For Evaluating Vancomycin Dosing Strategies, Bingyu Mao, Ziqian Xie, Laila Rasmy, Masayuki Nigo, Degui Zhi

Faculty, Staff and Student Publications

Achieving and maintaining the therapeutic range in vancomycin treatment is important for optimal outcomes. While guidelines and best practices based on empirical studies exist, the theoretical best dosing strategies under various conditions remain illusive. We developed an RL-based simulation framework using a deep learning two-compartment pharmacokinetic model (PK-RNN-2CM) and introduced the area under the time-concentration curve (AUC) reward score, which translates clinical guidelines into an RL reward. Ground truth time-concentration curves were generated from patient-specific data, and simulated curves were produced under different dosing strategies with optional noise perturbations to mimic real-world settings. Evaluation metrics included 24-hour AUC assessments and …

Registration Of Hyperspectral Images And Mass Spectrometry Data For The Correlation Of Tissue Optical Spectra And Molecular Profiles, Angie T Fei, Douglas W Strand, Jing Wang

Faculty, Staff and Student Publications

Hyperspectral imaging (HSI) is a label-free imaging modality that is emerging for non-invasive detection of various diseases including cancers. HSI provides high-resolution spatial images where each pixel has a spectral curve with numerous wavelength bands from the visible to infrared ranges. The rich spatial and spectral information can be used to discriminate various types of tissues and pathophysiological conditions. However, it can be difficult to explain spectral data with respect to the underline cellular and molecular mechanism. In this study, we developed an approach that registers hyperspectral images and mass spectrometry (MS) data where MS provides tissue molecular profiles. Human …

Refinement Of An Emergency Department-Based, Advance Care Planning Intervention For Patients With Cognitive Impairment And Their Caregivers, Kei Ouchi, Christopher Joshi, Jenson Kaithamattam, Seth A Gale, Gad A Marshall, Alison Pietras, Wei Wang, Edward W Boyer, James A Tulsky, Susan D Block, Dorene Rentz, Mara A Schonberg

Faculty, Staff and Student Publications

Background and objectives: Advance care planning (ACP) conversations are important to provide goal-concordant care (i.e., the care that matches the patient's previously stated goals) near end of life. While 31% of older adults presenting to the emergency department (ED) have dementia, only 39% have previously had ACP conversations. We refined and piloted an ED-based, motivational interview designed to stimulate ACP conversations (ED GOAL) for patients living with cognitive impairment and their caregivers.

Research design and methods: We systematically refined ED GOAL and then conducted an acceptability study in an urban, academic medical center. We prospectively enrolled adults aged 50+ with …

Editorial: Immunological Aspects Of Emerging And Re-Emerging Zoonoses, Wei Wang, Jingxin Li, Yuejin Liang, Wenping Gong

Faculty, Staff and Student Publications

No abstract provided.

Unicentric Castleman Disease: Illustration Of Its Morphologic Spectrum And Review Of The Differential Diagnosis, Siba El Hussein, Andrew G Evans, Hong Fang, Wei Wang, L Jeffrey Medeiros

Faculty, Staff and Student Publications

Context: Unicentric Castleman disease (UCD) is a dynamic entity with a wide spectrum of morphologic findings. UCD can be further subdivided into hyaline-vascular and mixed/plasmacytic variants. Hyaline-vascular UCD has both follicular and interfollicular (stromal) changes, and occasionally these lesions show a skewed representation of either the follicular or stromal compartments. Plasmacytosis is usually minimal in the hyaline-vascular variant. The mixed/plasmacytic variant of UCD is composed of sheets of plasma cells often associated with a variable number of follicles with regressive changes.

Objective: To illustrate the differential diagnosis of UCD, as it is quite broad and includes lymphomas, plasma cell neoplasms, …

Highly Variable Timing Renders Immunotherapy Efficacy And Toxicity Impractical Biomarkers Of One Another In Clinical Practice, Mitchell S Von Itzstein, Yuqiu Yang, Yiqing Wang, David Hsiehchen, Thomas Y Sheffield, Farjana Fattah, Vinita Popat, Murtaza Ahmed, Jade Homsi, Jonathan E Dowell, Sawsan Rashdan, Jay Lohrey, Hans J Hammers, Randall S Hughes, Tao Wang, Yang Xie, David E Gerber

Faculty, Staff and Student Publications

Background: A useful clinical biomarker requires not only association but also a consistent temporal relationship. For instance, chemotherapy-induced neutropenia and epidermal growth-factor inhibitor-related acneiform rash both occur within weeks of treatment initiation, thereby providing information prior to efficacy assessment. Although immune checkpoint inhibitor (ICI)-associated immune-related adverse events (irAE) have been associated with therapeutic benefit, irAE may have delayed and highly variable onset. To determine whether ICI efficacy and irAE could serve as clinically useful biomarkers for predicting each other, we determined the temporal relationship between initial efficacy assessment and irAE onset in a diverse population treated with ICI.

Methods: Using …

Foxp1 And Klf2 Reciprocally Regulate Checkpoints Of Stem-Like To Effector Transition In Car T Cells, Ziang Zhu, Guohua Lou, Xiao-Lu Teng, Haixia Wang, Ying Luo, Wangke Shi, Kiddist Yihunie, Shumeng Hao, Kole Degolier, Chengheng Liao, Huocong Huang, Qing Zhang, Terry Fry, Tao Wang, Chen Yao, Tuoqi Wu

Faculty, Staff and Student Publications

During cancers and infections, self-renewing stem-like CD8+ T cells mediate the response of immunotherapies and replenish terminally exhausted T cells and effector-like T cells. However, the programs governing the lineage choice in chimeric antigen receptor (CAR) T cells are unclear. Here, by simultaneously profiling single-cell chromatin accessibility and transcriptome in the same CAR T cells, we identified heterogeneous chromatin states within CD8+ T cell subsets that foreshadowed transcriptional changes and were primed for regulation by distinct transcription factors. Transcription factors that controlled each CD8+ T cell subset were regulated by high numbers of enhancers and positioned as hubs of gene …

Editorial: Advances And Methods In Mesenchymal Stem Cells, Pamela L Wenzel

Faculty, Staff and Student Publications

No abstract provided.

From Mitochondria To Tumor Suppression: Acat1’S Crucial Role In Gastric Cancer, Wei He, Yanfang Li, Song-Bai Liu, Ying Chang, Shiyuan Han, Xingyu Han, Zixin Ma, Hesham M Amin, Yao-Hua Song, Jin Zhou

Faculty, Staff and Student Publications

Acetyl CoA acetyltransferase 1 (ACAT1), a mitochondrial enzyme, is mainly involved in the formation and decomposition of ketones, isoleucine, and fatty acids. Previous clinical studies showed that mutations in the ACAT1 gene lead to ketoacidosis, Notably the role of ACAT1 in human cancer' pathogenesis varies depending on cancer type, and its specific role in gastric cancer remains largely unknown. In the current study, we found that the expression of ACAT1 in primary late-stage gastric cancer tumor tissues was significantly lower than in early-stage tumors. This observation was further confirmed in high-grade gastric cancer cell line MKN45. The expression of CD44 …

Sample Multiplexing In Cytof: Path To Optimize Single-Cell Proteomic Profiling, Muharrem Muftuoglu, Michael Andreeff

Faculty, Staff and Student Publications

Sample multiplexing significantly enhanced the depth of single-cell proteomic analysis in CyTOF (Cytometry by Time-Of-Flight). New polymer-based chelators have broadened the utility of metal isotopes, enabling improved tagging and simultaneous analysis of multiple samples. These approaches minimize batch effects, streamline experiments, conserve valuable samples, reduce costs, enhance throughput, and increase the accuracy of biological data, thereby facilitating novel discoveries.

Generation Of A Wt1 Conditional Deletion, Nuclear Red Fluorescent Protein Reporter Allele In The Mouse, Jace A Aloway, E Cristy Ruteshouser, Vicki Huff, Richard R Behringer

Faculty, Staff and Student Publications

A Wt1 conditional deletion, nuclear red fluorescent protein (RFP) reporter allele was generated in the mouse by gene targeting in embryonic stem cells. Upon Cre-mediated recombination, a deletion allele is generated that expresses RFP in a Wt1-specific pattern. RFP expression was detected in embryonic and adult tissues known to express Wt1, including the kidney, mesonephros, and testis. In addition, RFP expression and WT1 co-localization was detected in the adult uterine stroma and myometrium, suggesting a role in uterine function. Crosses with Wnt7a-Cre transgenic mice that express Cre in the Müllerian duct epithelium activate Wt1-directed RFP expression in the epithelium of …

Dysregulation Of Epigenetic Modifications In Inborn Errors Of Immunity, Zhongyao Xiao, Rongjing He, Zihan Zhao, Taiping Chen, Zhengzhou Ying

Faculty, Staff and Student Publications

Inborn errors of immunity (IEIs) are a group of typically monogenic disorders characterized by dysfunction in the immune system. Individuals with these disorders experience increased susceptibility to infections, autoimmunity and malignancies due to abnormal immune responses. Epigenetic modifications, including DNA methylation, histone modifications and chromatin remodeling, have been well explored in the regulation of immune cell development and effector function. Aberrant epigenetic modifications can disrupt gene expression profiles crucial for immune responses, resulting in impaired immune cell differentiation and function. Dysregulation of these processes caused by mutations in genes involving in epigenetic modifications has been associated with various IEIs. In …

Monitoring Variations In The Use Of Automated Contouring Software, Kelly A Nealon, Eun Young Han, Stephen F Kry, Callistus Nguyen, Mary Pham, Valerie K Reed, David Rosenthal, Samantha Simiele, Laurence E Court

Faculty, Staff and Student Publications

PURPOSE: Our purpose was to identify variations in the clinical use of automatically generated contours that could be attributed to software error, off-label use, or automation bias.

METHODS AND MATERIALS: For 500 head and neck patients who were contoured by an in-house automated contouring system, Dice similarity coefficient and added path length were calculated between the contours generated by the automated system and the final contours after editing for clinical use. Statistical process control was used and control charts were generated with control limits at 3 standard deviations. Contours that exceeded the thresholds were investigated to determine the cause. Moving …

Author Correction: Neoadjuvant Atezolizumab For Resectable Non-Small Cell Lung Cancer: An Open-Label, Single-Arm Phase Ii Trial, Jamie E Chaft, Filiz Oezkan, Mark G Kris, Paul A Bunn, Ignacio I Wistuba, David J Kwiatkowski, Dwight H Owen, Yan Tang, Bruce E Johnson, Jay M Lee, Gerard Lozanski, Maciej Pietrzak, Michal Seweryn, Woo Yul Byun, Katja Schulze, Alan Nicholas, Ann Johnson, Jessica Grindheim, Stephanie Hilz, David S Shames, Chris Rivard, Eric Toloza, Eric B Haura, Ciaran J Mcnamee, G Alexander Patterson, Saiama N Waqar, Valerie W Rusch, David P Carbone

Faculty, Staff and Student Publications

No abstract provided.

Editorial: Genetic And Cellular Heterogeneity In Tumors, Zishan Wang, Li Ma, Juan Xu, Chunjie Jiang

Faculty, Staff and Student Publications

No abstract provided.

Plain Language Summary Of The Foenix-Cca2 Study: Futibatinib For People With Advanced Bile Duct Cancer, Lipika Goyal, Funda Meric-Bernstam, Antoine Hollebecque, Juan W Valle, Chigusa Morizane, Thomas B Karasic, Thomas A Abrams, Junji Furuse, Robin Katie Kelley, Philippe A Cassier, Heinz-Josef Klümpen, Heung-Moon Chang, Li-Tzong Chen, Josep Tabernero, Do-Youn Oh, Amit Mahipal, Markus Moehler, Yoshito Komatsu, Daniel H Ahn, Robert S Epstein, Abdel-Baset Halim, Volker Wacheck, Yaohua He, Mei Liu, Karim A Benhadji, John A Bridgewater, Foenix-Cca2 Study Investigators

Faculty, Staff and Student Publications

What is this summary about?: This summary describes the results from a phase 2 study called FOENIXCCA2. The study evaluated treatment with futibatinib in people with a rare form of advanced bile duct cancer called intrahepatic cholangiocarcinoma (or iCCA), where the tumors have changes in the structure of a gene called FGFR2. These changes include FGFR2 gene fusions. Bile duct cancer often returns after surgery or cannot be treated by surgery because the tumor has spread, so it requires treatment with chemotherapy. People live for a median of 1 year after their first chemotherapy treatment and 6 months after their …

First-In-Human Phase 1 Study Of The Arginase Inhibitor Incb001158 Alone Or Combined With Pembrolizumab In Patients With Advanced Or Metastatic Solid Tumours, Aung Naing, Kyriakos P Papadopoulos, Michael J Pishvaian, Osama Rahma, Glenn J Hanna, Elena Garralda, Omar Saavedra, Sven Gogov, Howard Kallender, Lulu Cheng, Michael Smith, Xuejun Chen, Emil Kuriakose, Todd Bauer

Faculty, Staff and Student Publications

Objective: The arginase inhibitor INCB001158 was evaluated for safety (primary endpoint) in locally advanced or metastatic solid tumours; pharmacokinetics, pharmacodynamics and efficacy were also assessed.

Methods and analysis: In this non-randomised, open-label, three-part phase 1 study, INCB001158 was orally administered two times per day as monotherapy or in combination with intravenous pembrolizumab 200 mg every 3 weeks. Dose expansion was conducted in tumour-type cohorts (with or without prior anti-PD-1/PD-L1 (programmed death protein 1/programmed death ligand 1) therapy).

Results: A total of 107 patients received INCB001158 50-150 mg two times per day as monotherapy, and 153 patients, including 6 with moderate …

Tumor Treating Fields (Ttfields) For Spinal Metastasis–The Case For Bone Removal And Spinal Implants As Waveguides To Enhance Field Strength At The Target, Claudio E Tatsui, Kristen W Carlson, Chirag B Patel

Faculty, Staff and Student Publications

No abstract provided.