Bioethics and Medical Ethics Commons^™

Update - January 2009, Loma Linda University Center For Christian Bioethics

Update

In this issue:

-- Toward a Bioethics of Medicine
-- The Center is moving
-- Editorial
-- Adventist Declaration on Bioethics: Introductory Comments
-- In Focus: Villa Aurora
-- 2008 Contributor's Convocation: "Perspectives on Ethics from Around the World"

[ Claritás: Clarity on Ethics Essay Contest - Assisted Suicide: Good for Society or Not? ]
-- Mark Warren, School of Medicine, Loma Linda University First-place essay winner
-- Carissa Cianci, School of Nursing, Loma Linda University Second-place essay winner

From Yuck To Wow And Back Again, Dena S. Davis

Law Faculty Articles and Essays

This review essay discusses three recent books on the problem of "directed evolution," or genetic engineering, written from differing philosophical perspectives. The books are Babies by Design, by Ronald M. Green, Enhancing Evolution, by John Harris, and The Case against Perfection, by Michael J. Sandel.

Dead Men Reproducing: Responding To The Existence Of Afterdeath Children, Browne C. Lewis

Law Faculty Articles and Essays

The statutory mandates are a step in the right direction, but there is still work that needs to be done. The statutes should be amended to close certain loop holes and to ensure that the physician-facilitated suicide option is available to all of the patients who need it. Persons suffering from physical conditions that will lead to death within six months should not be the only persons permitted to exit gracefully. As long as the safeguards included in the statutes are followed, there is no good reason to prohibit persons suffering from irreversible and incurable physical diseases that lead to …

The Implications Of Post-Phase 1 And "Off-Label" Treatment Use Of Experimental Drugs: How Expansive Should Expanded Access Be?, Patricia J. Zettler

Faculty Publications By Year

No abstract provided.

The New Invention Creation Activity Boundary In Patent Law, Margo A. Bagley

Faculty Articles

This Essay identifies a new boundary in patent law - illegal or immoral invention creation activity - and explores the possible chal­lenges and opportunities it may facilitate. The boundary currently is neither robust nor extensive, and whether and under what cir­cumstances it should exist at all is open to debate.

Toward Credible Conflict Of Interest Policies In Clinical Psychiatry, Lisa Cosgrove, Harold J. Bursztajn

Counseling, School Psychology & Sport Faculty Publication Series

A recent letter to the American Psychiatric Association (APA) from Sen Chuck Grassley about the APA’s financial relationship with pharmaceutical companies raises concerns about undue industry influence. By instituting a disclosure policy for DSM-V, the APA took a halting first step in restoring public trust in the most influential text on psychiatric taxonomy in the world. Unfortunately, the APA’s efforts at creating a conflict of interest (COI) policy have failed to ensure that the process for revising diagnostic and therapeutic guidelines is one that the public can trust. The need for more safeguards was evidenced when the APA reported that …

Neuroscience And Health Law: An Integrative Approach?, Stacey A. Tovino

Faculty Articles

Clinicians and scientists use functional magnetic resonance imaging (fMRI) to map sensory, motor, and cognitive function and to study the neural correlates of a range of physical and mental conditions, behaviors, characteristics, and preferences. Due to its move outside the clinical and research contexts, fMRI raises a number of ethical, legal, and social issues that are being examined within the overlapping fields of neuroethics and neurolaw. The early neuroethics and neurolaw scholarship focused heavily on the implications of fMRI for evidence law, criminal law, criminal procedure, and constitutional law. Little attention has been paid, however, to the implications of advances …

Three Ways Of Looking At A Health Law And Literature Class, Jennifer Bard, Thomas Mayo, Stacey A. Tovino

Faculty Articles

The authors of this Article participated in a panel at the American Society of Law, Ethics & Medicine Conference in 2008 that examined the use of literary materials in law school to teach medical ethics (and related matters) in a law school setting. This Article and the panel on which it was based reflect views on how literature can play a valuable role in helping law students and medical students understand important legal and ethical issues and concepts in health law and bioethics. In Part I, Stacey Tovino introduces the parallel fields of “literature and medicine” and “law and literature” …

Hematologic Effects Of Placental Pathology On Very Low Birthweight Infants Born To Mothers With Preeclampsia., Kelly J. Zook, Md, Amy B. Mackley, Rnc, Jennifer Kern, David A. Paul. Md

Department of Pediatrics Faculty Papers

OBJECTIVE: To investigate the effect of placental pathology on neonatal neutrophils, platelets, hematocrit and nucleated red blood cells in very low birthweight (VLBW) infants born to mothers with preeclampsia. STUDY DESIGN: Retrospective cohort study of infants with birthweight < 1500 g born to mothers with preeclampsia from july, 2002 to july, 2006 at a single level III neonatal intensive care unit. Placental pathology was reviewed for the presence of placental infarction and vasculopathy. Hematologic parameters from day of life 0, 1 and 2 were obtained. Statistical analysis included repeated-measures analysis of variance and multivariable analysis using logistic regression. RESULT: The study sample included 203 infants with estimated gestational age of 28+/-3 weeks; 45% had placental infarctions and 26% placental vasculopathy. Infants with neutropenia and thrombocytopenia did not have an increased occurrence of placental infarction or maternal vasculopathy but were more likely to be of small gestational age (SGA) and of lower gestational age compared with infants without neutropenia or thrombocytopenia. After multivariable analysis, gestational age and SGA remained associated with both neutropenia and thrombocytopenia whereas placental infarction and vasculopathy did not remain in the models. CONCLUSION: In our population of VLBW infants born to mothers with preeclampsia, placental pathology was common. There was no association of placental infarction or vasculopathy with neonatal neutropenia and thrombocytopenia. The data suggest that neonatal hematologic effects of maternal preeclampsia, if related to the placenta, are associated with factors other than placental histology.

Increased Susceptibility Of Spinal Muscular Atrophy Fibroblasts To Camptothecin Is P53-Independent., Chia-Yen Wu, Ilsa Gómez-Curet, Vicky L Funanage, Mena Scavina, Wenlan Wang

Department of Pediatrics Faculty Papers

BACKGROUND: Deletion or mutation(s) of the survival motor neuron 1 (SMN1) gene causes spinal muscular atrophy (SMA). The SMN protein is known to play a role in RNA metabolism, neurite outgrowth, and cell survival. Yet, it remains unclear how SMN deficiency causes selective motor neuron death and muscle atrophy seen in SMA. Previously, we have shown that skin fibroblasts from SMA patients are more sensitive to the DNA topoisomerase I inhibitor camptothecin, supporting a role for SMN in cell survival. Here, we examine the potential mechanism of camptothecin sensitivity in SMA fibroblasts.

RESULTS: Camptothecin treatment reduced the DNA relaxation activity …

Autistic Disorder Associated With A Paternally Derived Unbalanced Translocation Leading To Duplication Of Chromosome 15pter-Q13.2: A Case Report., David J Wu, Nicholas J Wang, Jennette Driscoll, Naghmeh Dorrani, Dahai Liu, Marian Sigman, N Carolyn Schanen

Department of Pediatrics Faculty Papers

Autism spectrum disorders have been associated with maternally derived duplications that involve the imprinted region on the proximal long arm of chromosome 15. Here we describe a boy with a chromosome 15 duplication arising from a 3:1 segregation error of a paternally derived translocation between chromosome 15q13.2 and chromosome 9q34.12, which led to trisomy of chromosome 15pter-q13.2 and 9q34.12-qter. Using array comparative genome hybridization, we localized the breakpoints on both chromosomes and sequence homology suggests that the translocation arose from non-allelic homologous recombination involving the low copy repeats on chromosome 15. The child manifests many characteristics of the maternally-derived duplication …

Social Work Ethics Computer-Based Training Minnesota State University, Mankato Department Of Social Work, Rebecca Robinson-Wargelin

All Graduate Theses, Dissertations, and Other Capstone Projects

At the Community Behavioral Health Hospital, St.Peter (CBHH),a discussion was held regarding Ethics Continuing Education Hours(CEUs). The Minnesota Board of Social Work(MNBSW)and Minnesota State Statute 148D.130 require that Licensed Social Workers receive two hours of ethics-specific CEUsper licensure renewal. Through this discussion,it appeared that it would be beneficial to create an ethics computer-based training(CBT), which would be of no expense to State Operated Services(SOS)Social Workers.This option would also provide convenience for social workers, who as a majority,reside within rural areas.The CBT created is in accordance to requirements of the MNBSW and has an emphasis to include the National Association of …