Bioethics and Medical Ethics Commons^™

The Pluripotency Proposition: A Biological And Ethical Case For The Utilization Of Hipscs In Place Of Hescs, Drew Dickson

Senior Honors Theses

Human embryonic stem cell (hESC) research has spurred ethical controversy ever since it became feasible in 1998. The reason for this is due to the fact that hESC research requires the destruction of a human embryo, thereby causing the cessation of life for that developing human. Despite this unavoidable consequence, many advocates of hESC research hold to the belief that the embryo is not actually a human person, and therefore deem the destruction of the embryo as justifiable. Many advocates of hESC research also have pointed to the unprecedented medical potential of hESCs to argue in favor of their case. …

The Duty To Rescue In Genomic Research, Michael Ulrich

Student Articles and Papers

No abstract provided.

Screening Mammograms In Alzheimer’S Disease Patients, George M. Yousef, Piyush Sovani, Sirisha Devabhaktuni, Lynne J. Goebel

Internal Medicine

Very little guidance exists to help clinicians and families decide whether mammograms are useful in elderly women with Alzheimer’s Disease (AD). We present a case of a patient with moderate AD who had a positive mammogram and discuss the dilemma faced by the family and clinician in deciding what was best to do for the patient. In this case, the family opted for breast conserving surgery (BCS) followed by palliative care which brought up the question of whether screening was appropriate with this treatment goal in mind. We reviewed the literature on AD and breast cancer screening and summarize these …

Cosmetic Neurology: Enhancement Of The Mind And Attention Deficit Hyperactive Disorder Medication Abuse Among College Students, Mary M. Huff

Senior Honors Theses

Cosmetic neurology is becoming increasingly popular, and it is not just sleep deprived, over worked college students who are interested. People are beginning to seek off-label prescriptions for medications that are typically used to treat disorders such as attention deficit hyperactive disorder (ADHD) or narcolepsy, while researchers are trying to create drugs used solely for mind enhancement purposes. Along with these drugs come many legal and ethical quandaries relating to the regulation of current use as well as the what ifs of future possibilities. A survey was conducted among college students regarding the diagnosis of ADHD, the abuse of ADHD …

Manipulating Fate: Medical Innovations, Ethical Implications, Theatrical Illuminations, Karen H. Rothenberg, Lynn W. Bush

Faculty Scholarship

Transformative innovations in medicine and their ethical complexities create frequent confusion and misinterpretation that color the imagination. Placed in historical context, theatre provides a framework to reflect upon how the ethical, legal, and social implications of emerging technologies evolve over time and how attempts to control fate through medical science have shaped -- and been shaped by -- personal and professional relationships. The drama of these human interactions is powerful and has the potential to generate fear, create hope, transform identity, and inspire empathy -- a vivid source to observe the complex implications of translating research into clinical practice through …

A Proposal To Test The Effects Of Factor Ecat1 On Pluripotency, From Reprogramming To Differentiation Of Human Somatic Cells, Vritti R. Goel

CMC Senior Theses

The field of stem cell research has been growing more because of the interest in using stem cells to cure diseases and heal injuries. Human embryonic stem cells, because of the controversy surrounding them—and subsequently the difficulties in acquiring samples of the existing aging cell lines—can only be used in limited capacities. While the development of induced pluripotent stem cells in the last decade has allowed the field to progress closer to medical treatments, the low efficiency of reprogramming a somatic cell to a pluripotent state, and the vast molecular and genomic differences between human embryonic stem cells and human …

Insight Into Animal Cloning And The Food Chain: A Qualitative Examination Of Key Opinion Leaders And A Cross Section Of The Irish Public., Cathal Murphy

Masters

The ability to clone elite breeding animals, aimed at addressing the needs of modern food production, had been earmarked as a possibility for the agricultural sector since the birth of Dolly the sheep in 1996. A ruling by the Food and Drug Administration in the United States in 2008 that permits under-license, the commercial cloning of agricultural animals has seen this possibility realised. No such ruling exists here in Europe, but the FDA policy not to label cloned-derived products, and a history of wariness to food biotechnology in Europe may expedite this debate. With the plethora of issues that cloning …

Proteomic Assessment Of A Cell Model Of Spinal Muscular Atrophy., Chia-Yen Wu, Dosh Whye, Lisa Glazewski, Leila Choe, Douglas Kerr, Kelvin H Lee, Robert W Mason, Wenlan Wang

Department of Pediatrics Faculty Papers

BACKGROUND: Deletion or mutation(s) of the survival motor neuron 1 (SMN1) gene causes spinal muscular atrophy (SMA), a neuromuscular disease characterized by spinal motor neuron death and muscle paralysis. Complete loss of the SMN protein is embryonically lethal, yet reduced levels of this protein result in selective death of motor neurons. Why motor neurons are specifically targeted by SMN deficiency remains to be determined. In this study, embryonic stem (ES) cells derived from a severe SMA mouse model were differentiated into motor neurons in vitro by addition of retinoic acid and sonic hedgehog agonist. Proteomic and western blot analyses were …

Teratology Primer-2nd Edition (7/9/2010), Sura Alwan, Steven B. Bleyl, Robert L. Brent, Christina D. Chambers, George P. Daston, Elaine M. Faustman, Richard H. Finnell, F. Clarke Fraser, Jan M. Freidman, Adriane Fugh-Berman, John M. Graham, Jr., Barbara F. Hales, Deborah K. Hansen, Lewis B. Holmes, Ronald D. Hood, Robert J. Kavlock, Thomas B. Knudsen, Joseph Lary, Donald R. Mattison, Richard K. Miller, James L. Mills, Janine E. Polifka, Sonja A. Rasmussen, Bernard Robaire, John M. Rogers, Gary C. Schoenwolf, Anthony R. Scialli, Gary M. Shaw, Amar V. Singh, William Slikker, Jr., Ann P. Streissguth, Melissa S. Tassinari, Janet Uriu-Adams, Charles V. Vorhees, Elora J. Weringer

Department of Pediatrics Faculty Papers

Foreword:

What is Teratology?

“What a piece of work is an embryo!” as Hamlet might have said. “In form and moving how express and admirable! In complexity how infinite!” It starts as a single cell, which by repeated divisions gives rise to many genetically identical cells. These cells receive signals from their surroundings and from one another as to where they are in this ball of cells —front or back, right or left, headwards or tailwards, and what they are destined to become. Each cell commits itself to being one of many types; the cells migrate, combine into tissues, or …

Autistic Disorder Associated With A Paternally Derived Unbalanced Translocation Leading To Duplication Of Chromosome 15pter-Q13.2: A Case Report., David J Wu, Nicholas J Wang, Jennette Driscoll, Naghmeh Dorrani, Dahai Liu, Marian Sigman, N Carolyn Schanen

Department of Pediatrics Faculty Papers

Autism spectrum disorders have been associated with maternally derived duplications that involve the imprinted region on the proximal long arm of chromosome 15. Here we describe a boy with a chromosome 15 duplication arising from a 3:1 segregation error of a paternally derived translocation between chromosome 15q13.2 and chromosome 9q34.12, which led to trisomy of chromosome 15pter-q13.2 and 9q34.12-qter. Using array comparative genome hybridization, we localized the breakpoints on both chromosomes and sequence homology suggests that the translocation arose from non-allelic homologous recombination involving the low copy repeats on chromosome 15. The child manifests many characteristics of the maternally-derived duplication …

Update - January 2007, Loma Linda University Center For Christian Bioethics

Update

In this issue:

-- Stem Cells, Embryos, and Ethics: Is There a Way Forward?
-- Editorial
-- 2006 Contributor's Convocation "Present Day Health Care: Collaborate or Close the Door"

Update - March 2004, Loma Linda University Center For Christian Bioethics

Update

In this issue:

-- Christians Contemplating New Developments in Biomedicine
-- Editorial
-- Christian Principals of Genetic Intervention
-- Statement on Ethical Considerations Regarding Human Cloning
-- Honoring the Religious Impulse Within the Arena of Genetic Counseling

Update - September 2000, Loma Linda University Center For Christian Bioethics

Update

In this issue:

-- Takanobu Kinjo, Scott Winters and Nicole Wurscher graduate with degrees in Ethics and Ministry
-- Robert and Joyce Orr return to Vermont
-- Medical Theodicy Today
-- Changing our Genes: Medical Promises and Ethical Threats

Update - March 2000, Loma Linda University Center For Christian Bioethics

Update

In this issue:

-- National conference explores the future of faith-based health care
-- Ruth Macklin Judges Bioethical Relativism (Commentary)
-- Conditional Imortality and Cognitive Neuroscience
-- Clinical Ethics Consultation

Update - July 1998, Loma Linda University Center For Christian Bioethics

Update

In this issue:

-- Christianity and Human Cloning - A Seventh-day Adventist Declaration of Ethical Principles
-- Cloning: Dolly's Mother is Her Sister!?
-- Hello, Dolly! Dolly! Dolly!

Update - March 1997, Loma Linda University Center For Christian Bioethics

Update

In this issue:

-- James Walters publishes book on Personhood
-- Prayer and Health Care: An "Altared" Responsibility
-- Conference Report on "Bioethics and Human Destiny: Jewish and Christian Perspectives"

Update - February 1996, Loma Linda University Center For Christian Bioethics

Update

In this issue:

-- Adventism and Assisted Procreation: Excerpts from a panel discussion at LLU
-- Adventist Guidelines on Assisted Procreation
-- LLU offers Masters of Arts in Biomedical and Clinical Ethics

Update - March 1995, Loma Linda University Center For Christian Bioethics

Update

In this issue:

-- Cabbages and Condoms: Population Control in a Crowded World
-- On Conundrums, Condoms and Cabbages: "Prior Questions" on the Subject of Population Control
-- LLU offers Masters of Arts in Biomedical and Clinical Ethics

Update - September 1994, Loma Linda University Center For Christian Bioethics

Update

In this issue:

-- Ritualized Genital Mutilation the Procedure
-- A Cultural Perspective
-- Female Genital Mutilation: A Question of Fundamental Human Rights
-- Ethics When Cultures Clash
-- Ethics Consultation (Review)

Update - March 1994, Loma Linda University Center For Christian Bioethics

Update

In this issue:

-- The Human Genome Project: A Molecular Approach to Defining Humanity
-- Some Legal Ramifications for Newborns
-- Ethical and Legal Ramifications of Predictive Genetic Information
-- Graduate program combines biomedical and clinical ethics

Update - March 1993, Loma Linda University Center For Christian Bioethics

Update

In this issue:

-- Loma Linda offers Masters of Arts in Biomedical and Clinical Ethics and assists Claremont with Theological degree

[ Depo-Provera: Contraceptive Dream or Nightmare? ]
-- A Gynecologist's Perspective
-- Some Catholic Moral Reflections

-- Doctor of Philosophy at Claremont

Book Review, Bradley J. Olson

RISK: Health, Safety & Environment (1990-2002)

Review of the following: THE CODE OF CODES: SCIENTIFIC AND SOCIAL ISSUES IN THE HUMAN GENOME PROJECT. (Daniel J. Kevles & Leroy Hood, eds., Harvard University Press 1992) [397 pp.] Contributors, figures, index, notes, preface, selected bibliography, tables. LC 91-38477, ISBN 0- 674-13645-4. [Cloth $29.95. 79 Garden Street, Cambridge MA 02138.]

Genetics, Eugenics, And Public Policy, George P. Smith Ii

Scholarly Articles

No abstract provided.