Respiratory System Commons^™

Pulmonary Langerhans Cell Histiocytosis, Muhammad Irfan, Javed Hussain, Riaz Lakdawala, Fayyaz Hussain, Javaid Khan

Section of Pulmonary & Critical Care

No abstract provided.

Oxygen Saturation Among Newborn Infants And The Decrease Occurring During Feeding In Various Populations, Jennifer Lynn Allison

MUSC Theses and Dissertations

Pharyngeal and laryngeal structural movements coordinate respiration and swallowing functions, hence eliminating simultaneous execution. This research aims to document levels of oxygen saturation during rest and feeding among various newborn populations. Hypothesized is that an increase in oxygen alterations during feeding will be exhibited by infants of younger gestational age and, further, by those with the presence of respiratory anomalies. Thirty newborns in the nurseries at Medical University of South Carolina, free of cardiac and genetic maladies, were divided into three groups. Subjects of group 1 are healthy, full-term newborns; within groups 2 and 3, preterm infants (gestation). Subjects of …

Platelets Stimulate Fibroblast-Mediated Contraction Of Collagen Gels, Ulrika Zagai, Karin Fredriksson, Stephen I. Rennard, Joachim Lundahl, C. Magnus Sköld

Journal Articles: Pulmonary & Critical Care Med

BACKGROUND: Platelets are thought to play a role in a variety of inflammatory conditions in the lung, some of which may lead to fibrosis. In the current study we tested the hypothesis that whole platelets and platelet lysate can mediate remodelling of extracellular matrix in vitro by affecting fibroblast-mediated contraction of a collagen gel. We also sought to determine to what extent platelet-derived growth factor (PDGF) and transforming growth factor-beta (TGF-beta) contribute to this effect.

METHODS: Washed platelets, isolated from healthy blood donors, and platelet lysate (freezing and thawing), were cast together with human lung fibroblasts in three-dimensional collagen gels. …