Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Aerodynamics and Fluid Mechanics (1)
- Aerospace Engineering (1)
- Analytical, Diagnostic and Therapeutic Techniques and Equipment (1)
- Applied Mathematics (1)
- Biomechanical Engineering (1)
-
- Biomedical Devices and Instrumentation (1)
- Biomedical Engineering and Bioengineering (1)
- Chemicals and Drugs (1)
- Chemistry (1)
- Computer Sciences (1)
- Computer-Aided Engineering and Design (1)
- Diseases (1)
- Electro-Mechanical Systems (1)
- Engineering (1)
- Fluid Dynamics (1)
- Investigative Techniques (1)
- Life Sciences (1)
- Mechanical Engineering (1)
- Medical Specialties (1)
- Medicinal Chemistry and Pharmaceutics (1)
- Medicinal-Pharmaceutical Chemistry (1)
- Nanomedicine (1)
- Nanoscience and Nanotechnology (1)
- Nanotechnology (1)
- Numerical Analysis and Computation (1)
- Numerical Analysis and Scientific Computing (1)
- Keyword
Articles 1 - 2 of 2
Full-Text Articles in Respiratory System
Nebulizer-Based Systems To Improve Pharmaceutical Aerosol Delivery To The Lungs, Benjamin M. Spence
Nebulizer-Based Systems To Improve Pharmaceutical Aerosol Delivery To The Lungs, Benjamin M. Spence
Theses and Dissertations
Combining vibrating mesh nebulizers with additional new technologies leads to substantial improvements in pharmaceutical aerosol delivery to the lungs across therapeutic administration methods. In this dissertation, streamlined components, aerosol administration synchronization, and/or Excipient Enhanced Growth (EEG) technologies were utilized to develop and test several novel devices and aerosol delivery systems. The first focus of this work was to improve the poor delivery efficiency, e.g., 3.6% of nominal dose (Dugernier et al. 2017), of aerosolized medication administration to adult human subjects concurrent with high flow nasal cannula (HFNC) therapy, a form of continuous-flow non-invasive ventilation (NIV). The developed Low-Volume Mixer-Heater (LVMH) …
Computational Fluid Dynamics In A Terminal Alveolated Bronchiole Duct With Expanding Walls: Proof-Of-Concept In Openfoam, Jeremy Myers
Computational Fluid Dynamics In A Terminal Alveolated Bronchiole Duct With Expanding Walls: Proof-Of-Concept In Openfoam, Jeremy Myers
Theses and Dissertations
Mathematical Biology has found recent success applying Computational Fluid Dynamics (CFD) to model airflow in the human lung. Detailed modeling of flow patterns in the alveoli, where the oxygen-carbon dioxide gas exchange occurs, has provided data that is useful in treating illnesses and designing drug-delivery systems. Unfortunately, many CFD software packages have high licensing fees that are out of reach for independent researchers. This thesis uses three open-source software packages, Gmsh, OpenFOAM, and ParaView, to design a mesh, create a simulation, and visualize the results of an idealized terminal alveolar sac model. This model successfully demonstrates that OpenFOAM can be …