Therapeutics Commons^™

Effects Of Hepatic Ischemia-Reperfusion Injury On The P-Glycoprotein Activity At The Liver Canalicular Membrane And Blood-Brain Barrier Determined By In Vivo Administration Of Rhodamine 123 In Rats, M. K. Miah, Imam H. Shaik, Ulrich Bickel, Reza Mehvar

Pharmacy Faculty Articles and Research

Purpose To investigate the effects of normothermic hepatic ischemia-reperfusion (IR) injury on the activity of P-glycoprotein (P-gp) in the liver and at the blood-brain barrier (BBB) of rats using rhodamine 123 (RH-123) as an in vivo marker.

Methods Rats were subjected to 90 min of partial ischemia or sham surgery, followed by 12 or 24 h of reperfusion. Following intravenous injection, the concentrations of RH-123 in blood, bile, brain, and liver were used for pharmacokinetic calculations. The protein levels of P-gp and some other transporters in the liver and brain were also determined by Western blot analysis.

Results P-gp protein …

Ultrasound Imaging Of Lumbar Multifidus Immediately Following Three Physical Therapy Techniques In Asymptomatic Individuals, Victoria Byers, Steven Lim, Kathryn Rice

UNLV Theses, Dissertations, Professional Papers, and Capstones

Study Design

Randomized, blinded, cohort, within subjects design.

Background and Objective

The effects of different manual therapy (MT) techniques on lumbar multifidus (LM) thickness have been investigated in subjects with low back pain (LBP) but have not been investigated in asymptomatic subjects. The objective of this study was to examine the immediate effects of mobilization and manipulation on contraction thickness of LM in healthy individuals.

Methods and Measures

Forty-two healthy individuals participated in the study. Ultrasound imaging techniques were used to record LM thickness (L4-5 level) at rest, during an abdominal drawing in maneuver (ADIM), and during a prone upper …

Small Intestine Submucosa For Repair Of Injured Rabbit Cornea: A Pilot Study, Mark Nicholas Perenich

PCOM Biomedical Studies Student Scholarship

Corneal injuries blind approximately 15 million people worldwide annually. Current methods of treatment have several disadvantages with respect to cost and availability. This study evaluated a small intestine submucosa (SIS) xenograft treatment for a severe corneal injury. SIS could be a favorable alternative to the current treatment methods, because it is inexpensive to produce and abundant where pigs are consumed. A severe ocular injury was created in the right eye of 5 rabbits by n-heptanol and mechanical debridement of the cornea and limbus. The cornea was then evaluated with fluorescence stain and a SIS xenograft was used for treatment. Clinical …