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2023

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Articles 481 - 510 of 511

Full-Text Articles in Analytical, Diagnostic and Therapeutic Techniques and Equipment

A Case Study On Treatment Of Subcoracoid Impingement In An Overhead Athlete With Manual Therapy, M Mennell Jan 2023

A Case Study On Treatment Of Subcoracoid Impingement In An Overhead Athlete With Manual Therapy, M Mennell

Clinical Practice in Athletic Training

Introduction: Subcoracoid impingement of the shoulder is a condition that occurs when the tendons or soft tissues in the shoulder are compressed or pinched between the coracoid process and the humeral head. It is also suspected that subcoracoid impingement can occur when the humerus translates anteriorly, decreasing the subcoracoid space. This impingement can cause pain, inflammation, and limited mobility in the shoulder joint. All kinds of impingement are typically multifactorial, and have several areas that need to be addressed. The purpose of this case report is to examine the effects of therapeutic exercise as well as manual therapy on subcoracoid …


Superficial Peroneal Nerve Entrapment In Female Collegiate Tennis Athlete: A Disablement Model Case Study, Sarah Branning, Neeru Jayanthi, Zachary K. Winkelmann Jan 2023

Superficial Peroneal Nerve Entrapment In Female Collegiate Tennis Athlete: A Disablement Model Case Study, Sarah Branning, Neeru Jayanthi, Zachary K. Winkelmann

Clinical Practice in Athletic Training

A 19-year-old female, NCAA Division I collegiate tennis player presented with a burning and aching sensation halfway up the lateral portion of her right calf following an extensive period spent in a squatting position. This discomfort began distal to the fibular head, then ran along her lateral calf, reached into her ankle, and wrapped behind the lateral malleolus. Initially, the patient only noticed this discomfort during long durations of physical activity. However, she began to report symptoms with activities of daily living (ADLs) and following workouts. The patient first received a working diagnosis of a stress reaction along the mid …


Return-To-Tennis Considerations And An Elusive Diagnosis For A Cuboid Avulsion Fracture: A Disablement Model Case Study, Grant G. Yee, Zachary K. Winkelmann, Zoe J. Foster Jan 2023

Return-To-Tennis Considerations And An Elusive Diagnosis For A Cuboid Avulsion Fracture: A Disablement Model Case Study, Grant G. Yee, Zachary K. Winkelmann, Zoe J. Foster

Clinical Practice in Athletic Training

This disablement-model case study is focused on a 23-year-old NCAA Division I men’s tennis player that sustained an injury in a competitive singles tennis match. Upon initial examination, the athletic trainer diagnosed the individual with an anterior talofibular ligament sprain and treated conservatively. The patient experienced significant disruptions to his activities of daily living due to his difficulties with ambulation during the early stages of his recovery. Interestingly, the patient was eventually diagnosed with a cuboid avulsion fracture. Midfoot fractures are uncommonly experienced in the general population, and are particularly uncommon in tennis athletes, making them difficult to recognize. Clinical …


The Validity And Reliability Of Assessments Through Telemedicine: An Evidence-To-Practice Review, Connor L. Givens, Gabrielle A. Griffin, Matthew D. Johnson, Zachary K. Winkelmann Jan 2023

The Validity And Reliability Of Assessments Through Telemedicine: An Evidence-To-Practice Review, Connor L. Givens, Gabrielle A. Griffin, Matthew D. Johnson, Zachary K. Winkelmann

Clinical Practice in Athletic Training

The validity and reliability of telemedicine assessments has been explored through numerous studies. Telemedicine is a diagnostic tool that combines visual technology, audio technology, and tools for assessment. The assessment of musculoskeletal disorders is a key portion in the field of athletic training. The development of telemedicine assessment tools has improved over time but has not yet been perfected. Data was collected via four databases that included articles examining validity, inter- and intra- rater reliability, and telemedicine assessment for musculoskeletal tests. The reviews of the systematic review used Quality Assessment of Diagnostic Accuracy Studies (QUADAS) and quality appraisal tool for …


Effects Of Social Determinants Of Health And Diabetes On A Lower Extremity Workplace Injury: A Disablement Model Case Study, Bridget L. Davidson, Richelle M. Williams, Sean M. Rogers Jan 2023

Effects Of Social Determinants Of Health And Diabetes On A Lower Extremity Workplace Injury: A Disablement Model Case Study, Bridget L. Davidson, Richelle M. Williams, Sean M. Rogers

Clinical Practice in Athletic Training

This clinical case study involves a 36-year-old male patient who injured his right lower leg while working in the kitchen at a county correctional institution. The mechanism of injury involved the patient getting his foot caught under a wooden pallet, losing his balance, and then catching himself on his right leg in a twisting motion. The injury led to the patient seeking care in the emergency department and was diagnosed with a nonspecific strain of the right triceps surae muscle group. Upon discharge, the patient was referred to outpatient athletic training services within the hospital system. Follow-up care provided by …


University Football Player With Hoffa’S Fat Pad Syndrome: A Disablement Model Case Study, Kaitlyn Jones, Kristy Dao, Zachary K. Winkelmann Jan 2023

University Football Player With Hoffa’S Fat Pad Syndrome: A Disablement Model Case Study, Kaitlyn Jones, Kristy Dao, Zachary K. Winkelmann

Clinical Practice in Athletic Training

A 23-year-old university football player presented with acute onset anterior knee pain with no distinct mechanism of injury. The pain began soon after the start of fall football camp and prevented the patient from participating in team activities, including weights and practices. Along with pain, the patient experienced edema, decreased knee flexion range of motion, and an antalgic gait. The findings of the evaluation of this patient were consistent with Hoffa’s fat pad syndrome, an inflammatory and impingement condition of the infrapatellar fat pad that is often a rare diagnosis of exclusion. Conservative treatment was used for this patient, which …


Acute Management Of An Abdominal Cavity Perforation In A Collegiate Baseball Pitcher: A Case Report., D M. Gallegos, A P. Jacobsen, R M. Galbraith, R L. Peebles, B J. Warner, S A. Cage Jan 2023

Acute Management Of An Abdominal Cavity Perforation In A Collegiate Baseball Pitcher: A Case Report., D M. Gallegos, A P. Jacobsen, R M. Galbraith, R L. Peebles, B J. Warner, S A. Cage

Clinical Practice in Athletic Training

Background: A 21-year-old male collegiate baseball player was performing warm up exercises when he tripped backwards onto one of the team’s pitching machines that had been laid on its side. Upon falling backward, the patient sustained a puncture wound through the left buttock from one of the machine’s handles. Unaware of the injury, the patient’s teammates lifted him off of the machine and retrieved the athletic trainer. Evaluation revealed a deep wound with visible adipose tissue and musculature. At this time, the patient was immediately transported to the emergency department of the local hospital, and team physicians were informed to …


The Effects Of Dry Cupping Therapy On Touch Pressure Threshold In Collegiate Baseball Players., S A. Cage, R L. Peebles, J D. Volpi, L E. Trail, B J. Warner Jan 2023

The Effects Of Dry Cupping Therapy On Touch Pressure Threshold In Collegiate Baseball Players., S A. Cage, R L. Peebles, J D. Volpi, L E. Trail, B J. Warner

Clinical Practice in Athletic Training

Introduction: Cupping therapy is a therapeutic modality that uses negative pressures to achieve therapeutic benefits. Various published studies report that cupping therapy decreases pain, increases range of motion, and improves blood flow. Previous studies also report an effect on tissue tenderness. However, there do not appear to be any studies assessing the effects of cupping therapy on touch pressure threshold, which measures skin sensitivity. Changes in touch pressure threshold may provide more information on the neurological effect cupping therapy has on treated tissues. The purpose of this study was to compare the effects of cupping therapy on touch pressure threshold …


Hook Of The Hamate Fracture In A Collegiate Baseball Player Preceded By A Hamate Stress Fracture, H N. Parker, R M. Galbraith, A P. Jacobsen, C Hodges, B J. Warner, S A. Cage Jan 2023

Hook Of The Hamate Fracture In A Collegiate Baseball Player Preceded By A Hamate Stress Fracture, H N. Parker, R M. Galbraith, A P. Jacobsen, C Hodges, B J. Warner, S A. Cage

Clinical Practice in Athletic Training

Background: A 21-year-old male collegiate baseball player reported to the athletic training staff complaining of pain along the hypothenar eminence of the left hand. The patient’s pain was intensified when swinging a bat but remained constant even at rest. The patient reported symptoms beginning approximately three weeks prior to being evaluated by the athletic training staff, but delaying reporting symptoms in order to continue playing. Physical exam revealed tenderness over the hook of the hamate and hypothenar eminence, decreased active wrist extension, decreased grip strength, and pain with resisted pronation and supination. At this time, the patient was removed from …


The Diagnosis, Rehabilitation, And Treatment Of Posterior Impingement In A High School Baseball Pitcher, K Tisdale Jan 2023

The Diagnosis, Rehabilitation, And Treatment Of Posterior Impingement In A High School Baseball Pitcher, K Tisdale

Clinical Practice in Athletic Training

Introduction: Posterior impingement, also known as internal impingement, is a type of secondary impingement that is caused by overuse and repetitive movements of the shoulder overhead during motions such as throwing, spiking, etc. A combination of shoulder abduction and external rotation produces impingement of the infraspinatus and/or of the supraspinatus against the posterior-superior glenoid. Posterior impingement is common in overhead athletes, and this mechanism is usually seen during the cocking phase of throwing. Someone suffering from posterior impingement may complain of posterior shoulder pain, posterior stiffness and decline in performance. Patient Information: In this case study, a 15- year-old male …


Low Ferritin Count In Female Collegiate Soccer Player Presents As Concussion, E N. Nelson, T D. Pitcock, M K. Knoblauch, L J. Harrison Jan 2023

Low Ferritin Count In Female Collegiate Soccer Player Presents As Concussion, E N. Nelson, T D. Pitcock, M K. Knoblauch, L J. Harrison

Clinical Practice in Athletic Training

Background: Women’s soccer leads the National Collegiate Athletic Association for having the highest number of concussions in female sports. Common symptoms of concussion can include light headedness, headaches, and dizziness, but these symptoms are not exclusive to concussions. Female athletes may experience nutritional deficits that can lead to a wide range of symptoms mimicking those commonly experienced with a concussion such as headaches, dizziness, and fatigue. The patient in this case is a 21- year-old female soccer athlete who presented with sensitivity to light, light headedness, nausea, and fatigue after experiencing repeated ‘headers’ as well as a collision during a …


A Case Report Of The Evaluation And Management Of Low Back Pain In A High School Basketball Player, K Leveston, K Neelon, E Ephran Jan 2023

A Case Report Of The Evaluation And Management Of Low Back Pain In A High School Basketball Player, K Leveston, K Neelon, E Ephran

Clinical Practice in Athletic Training

Background: Low back pain can be a tough injury to endure, especially in the growing high school athlete.3 LBP in a high school athlete can be caused by various factors, such as structural deformities, mobility deficits, and so much more. The majority of LBP in adolescents is nonspecific LBP, which is defined as LBP that does not cause systemic or structural changes.5 Nonspecific LBP is often a result of other etiologies such as hypermobile or hypomobile segments of the spine, hip mobility deficits, gait, sleeping positions, or improper weightlifting form. Differential Diagnoses: Other possible diagnoses of LBP in adolescents could …


Figure-8-Reconstruction Of Posterior Sternoclavicular Joint Dislocation 18 Days Post Initial Injury, M Suri, S Bunemann Jan 2023

Figure-8-Reconstruction Of Posterior Sternoclavicular Joint Dislocation 18 Days Post Initial Injury, M Suri, S Bunemann

Clinical Practice in Athletic Training

Introduction: Traumatic sternoclavicular joint injuries account for less than 3% of all traumatic joint injuries1. Although rare, posterior dislocation of the sternoclavicular joint has the potential to be life-threatening due to the proximity of vital structures posterior to the manubrium. This injury typically requires a high-energy force applied through the joint2. SC dislocations become increasingly difficult to reduce after 24 hours, so timely diagnosis and treatment are important. Glass et al. found mediastinal compression occurred 30% of the time with posterior dislocations. If left untreated, prolonged pressure on the superior mediastinum can cause erosion of the great vessels, tracheoesophageal fistula, …


Review Of Diagnostic Accuracy Of The Ottawa Knee Rules In Adult Acute Knee Injuries, Sean L. Glover, Amy M. Loveless, Sara A. Posson, Zachary K. Winkelmann Jan 2023

Review Of Diagnostic Accuracy Of The Ottawa Knee Rules In Adult Acute Knee Injuries, Sean L. Glover, Amy M. Loveless, Sara A. Posson, Zachary K. Winkelmann

Clinical Practice in Athletic Training

Acute knee injuries are commonly found in athletic populations. The wide range of knee injuries can present a challenge deciding which injuries require imaging. Currently, radiography is considered the gold standard of imaging for knee fractures. However, imaging is often costly not only for the patient, but also for the healthcare system. Since imaging is expensive, it is critical that clinicians decipher which patients require such testing. The Ottawa Knee Rules (OKR) is a predictor tool created by Stiell et al in 1995 to help clinicians accurately distinguish potential knee fractures from non-fractures for imaging purposes. The OKR guidelines state …


The Impact Of Bracing On Kinesiophobia And Recovery In Acl Reconstruction Patients: A Case Study, N Valdecanas, K Neelon, K Braunreiter Jan 2023

The Impact Of Bracing On Kinesiophobia And Recovery In Acl Reconstruction Patients: A Case Study, N Valdecanas, K Neelon, K Braunreiter

Clinical Practice in Athletic Training

Introduction: With 100,000 to 200,000 cases reported in the U.S. yearly, the anterior cruciate ligament (ACL) is a commonly torn structure in the knee among contact and non-contact sports. As medical research on ACL injuries grows, ACL reconstruction (ACLR) continues to be the preferred surgical intervention. Due to extensive rehabilitation timeline requirements, ACLR patients may face physical and psychosocial circumstances affecting their overall recovery. At any point in rehabilitation the patient may experience kinesiophobia, or an irrational fear relating to further injury from participation in physical movement, especially with return to running, jumping, and sports-specific programs. Functional bracing has been …


Soft X-Ray And Susceptibility Based Magnetic Resonance Imaging To Map Iron Distribution In Apples: Initial Results To Model Iron Storage In Water-Deficient Or Dehydrated Biological Tissue, Subhendra N. Sarkar, Eric Lobel, Evans Lespinasse, Zoya Vinokur, Analia Basilicata, Sonia Orellana, Maria Orellana, Aaliyah Salmon, Joanna Syska, Aravis Mcbroom, Jian Wang, Anam Riaz, Jodi-Ann Douglas Jan 2023

Soft X-Ray And Susceptibility Based Magnetic Resonance Imaging To Map Iron Distribution In Apples: Initial Results To Model Iron Storage In Water-Deficient Or Dehydrated Biological Tissue, Subhendra N. Sarkar, Eric Lobel, Evans Lespinasse, Zoya Vinokur, Analia Basilicata, Sonia Orellana, Maria Orellana, Aaliyah Salmon, Joanna Syska, Aravis Mcbroom, Jian Wang, Anam Riaz, Jodi-Ann Douglas

Publications and Research

Radiology departments have contributed significantly to greenhouse gases including release of toxic imaging contrast media to environment. We feel Radiology also has several spectroscopy and imaging tools that may apply to monitor and support cleaner environmental goals. The current manuscript is one of the firsts to prompt Radiology to move in that direction by non invasive imaging of bio metals that are less abundant in biological tissues but play key roles as co-factors in tissue structure and function. Conventional analytical tools are mostly invasive and cannot characterize the native oxidation states of bio metals. We chose carbohydrate matrix of metal-rich …


Toward Real-Time, Robust Wearable Sensor Fall Detection Using Deep Learning Methods: A Feasibility Study, Haben Yhdego, Christopher Paolini, Michel Audette Jan 2023

Toward Real-Time, Robust Wearable Sensor Fall Detection Using Deep Learning Methods: A Feasibility Study, Haben Yhdego, Christopher Paolini, Michel Audette

Electrical & Computer Engineering Faculty Publications

Real-time fall detection using a wearable sensor remains a challenging problem due to high gait variability. Furthermore, finding the type of sensor to use and the optimal location of the sensors are also essential factors for real-time fall-detection systems. This work presents real-time fall-detection methods using deep learning models. Early detection of falls, followed by pneumatic protection, is one of the most effective means of ensuring the safety of the elderly. First, we developed and compared different data-segmentation techniques for sliding windows. Next, we implemented various techniques to balance the datasets because collecting fall datasets in the real-time setting has …


Prediction Of Rapid Early Progression And Survival Risk With Pre-Radiation Mri In Who Grade 4 Glioma Patients, Walia Farzana, Mustafa M. Basree, Norou Diawara, Zeina Shboul, Sagel Dubey, Marie M. Lockheart, Mohamed Hamza, Joshua D. Palmer, Khan Iftekharuddin Jan 2023

Prediction Of Rapid Early Progression And Survival Risk With Pre-Radiation Mri In Who Grade 4 Glioma Patients, Walia Farzana, Mustafa M. Basree, Norou Diawara, Zeina Shboul, Sagel Dubey, Marie M. Lockheart, Mohamed Hamza, Joshua D. Palmer, Khan Iftekharuddin

Electrical & Computer Engineering Faculty Publications

Rapid early progression (REP) has been defined as increased nodular enhancement at the border of the resection cavity, the appearance of new lesions outside the resection cavity, or increased enhancement of the residual disease after surgery and before radiation. Patients with REP have worse survival compared to patients without REP (non-REP). Therefore, a reliable method for differentiating REP from non-REP is hypothesized to assist in personlized treatment planning. A potential approach is to use the radiomics and fractal texture features extracted from brain tumors to characterize morphological and physiological properties. We propose a random sampling-based ensemble classification model. The proposed …


Virtual Surgical Planning In Craniomaxillofacial Surgery: A Structured Review, Kaye Verlarde, Rentor Cafino, Armando Isla Jr., Karen Mae Ty, Xavier-Lewis Palmer, Lucas Potter, Larry Nadorra, Luchin Valrian Pueblos, Lemuel Clark Velasco Jan 2023

Virtual Surgical Planning In Craniomaxillofacial Surgery: A Structured Review, Kaye Verlarde, Rentor Cafino, Armando Isla Jr., Karen Mae Ty, Xavier-Lewis Palmer, Lucas Potter, Larry Nadorra, Luchin Valrian Pueblos, Lemuel Clark Velasco

Electrical & Computer Engineering Faculty Publications

Craniomaxillofacial (CMF) surgery is a challenging and very demanding field that involves the treatment of congenital and acquired conditions of the face and head. Due to the complexity of the head and facial region, various tools and techniques were developed and utilized to aid surgical procedures and optimize results. Virtual Surgical Planning (VSP) has revolutionized the way craniomaxillofacial surgeries are planned and executed. It uses 3D imaging computer software to visualize and simulate a surgical procedure. Numerous studies were published on the usage of VSP in craniomaxillofacial surgery. However, the researchers found inconsistency in the previous literature which prompted the …


A Quality Improvement Project To Improve Management Of Urinary Tract Infections In A System Of Pediatric Urgent Care Centers, Benjamin Klick, Tammy Speerhas, Jessica Parrott, Jeffrey Bobrowitz, Anne Mcevoy, Debra Conrad, Theresa Guins Jan 2023

A Quality Improvement Project To Improve Management Of Urinary Tract Infections In A System Of Pediatric Urgent Care Centers, Benjamin Klick, Tammy Speerhas, Jessica Parrott, Jeffrey Bobrowitz, Anne Mcevoy, Debra Conrad, Theresa Guins

Ellmer School of Nursing Faculty Publications

Background and objective: Urinary tract infections (UTIs) are a common problem in pediatric urgent care medicine. There are multiple quality improvement (QI) projects related to the management of UTIs documented in the pediatric literature. We developed a project to decrease the prescribing of ultimately unneeded antibiotics for possible UTIs in a pediatric urgent care setting. A similar project has not been described in the pediatric literature.

Methods: We first reviewed the charts of patients presenting to a system of pediatric urgent care centers with a possible UTI over a 2-year period. We then launched a QI project with three plan, …


A Comparison Of Chief Complaints, Specific Diagnoses, And Demographics Of Pediatric Urgent Care Visits Before And During The Covid-19 Pandemic: A Retrospective Study, Zaharoula A. Viennas, Julie Martin, Benjamin Klick, Tammy Speerhas, Turaj Vazifedan, Danielle Millspaugh, Jennifer Ferris, Margret Bedle, Lauren Paluch, Theresa Guins Jan 2023

A Comparison Of Chief Complaints, Specific Diagnoses, And Demographics Of Pediatric Urgent Care Visits Before And During The Covid-19 Pandemic: A Retrospective Study, Zaharoula A. Viennas, Julie Martin, Benjamin Klick, Tammy Speerhas, Turaj Vazifedan, Danielle Millspaugh, Jennifer Ferris, Margret Bedle, Lauren Paluch, Theresa Guins

Ellmer School of Nursing Faculty Publications

There was an increased incidence of pediatric patients who presented with injuries caused by falls not related to sports or other recreational activities, as well as for animal bites, during the early pandemic period of April 2020. Education of parents and caregivers of young children is warranted to raise awareness of the even greater potential for falls and animal bites when children are confined at home for longer than typical periods of time, as occurred with the stay-at-home government orders during the initial period of the COVID-19 pandemic.


Identifying The Serious Clinical Outcomes Of Adverse Reactions To Drugs By A Multi-Task Deep Learning Framework, Haochen Zhao, Peng Ni, Qichang Zhao, Xiao Liang, Di Ai, Shannon Erhardt, Jun Wang, Yaohang Li, Jiianxin Wang Jan 2023

Identifying The Serious Clinical Outcomes Of Adverse Reactions To Drugs By A Multi-Task Deep Learning Framework, Haochen Zhao, Peng Ni, Qichang Zhao, Xiao Liang, Di Ai, Shannon Erhardt, Jun Wang, Yaohang Li, Jiianxin Wang

Computer Science Faculty Publications

Adverse Drug Reactions (ADRs) have a direct impact on human health. As continuous pharmacovigilance and drug monitoring prove to be costly and time-consuming, computational methods have emerged as promising alternatives. However, most existing computational methods primarily focus on predicting whether or not the drug is associated with an adverse reaction and do not consider the core issue of drug benefit-risk assessment-whether the treatment outcome is serious when adverse drug reactions occur. To this end, we categorize serious clinical outcomes caused by adverse reactions to drugs into seven distinct classes and present a deep learning framework, so-called GCAP, for predicting the …


Msdrp: A Deep Learning Model Based On Multisource Data For Predicting Drug Response, Haochen Zhao, Xiaoyu Zhang, Qichang Zhao, Yaohang Li, Jianxin Wang Jan 2023

Msdrp: A Deep Learning Model Based On Multisource Data For Predicting Drug Response, Haochen Zhao, Xiaoyu Zhang, Qichang Zhao, Yaohang Li, Jianxin Wang

Computer Science Faculty Publications

Motivation: Cancer heterogeneity drastically affects cancer therapeutic outcomes. Predicting drug response in vitro is expected to help formulate personalized therapy regimens. In recent years, several computational models based on machine learning and deep learning have been proposed to predict drug response in vitro. However, most of these methods capture drug features based on a single drug description (e.g. drug structure), without considering the relationships between drugs and biological entities (e.g. target, diseases, and side effects). Moreover, most of these methods collect features separately for drugs and cell lines but fail to consider the pairwise interactions between drugs and cell …


Analysis Of D- And L- Isomers Of (Meth)Amphetamine In Human K2edta Plasma, Brian Robbins, Jacob Perry, Mary Long, Rob E. Carpenter Jan 2023

Analysis Of D- And L- Isomers Of (Meth)Amphetamine In Human K2edta Plasma, Brian Robbins, Jacob Perry, Mary Long, Rob E. Carpenter

Human Resource Development Faculty Publications and Presentations

Methamphetamine and its metabolite amphetamine are frequently abused drugs. Whether obtained legally or from clandestine laboratories it is of relevance to determine the chiral makeup of these drugs for investigative purpose. Although urine and oral fluid matrices are commonly offered, less available to independent laboratories are techniques to verify dextro (D-) or levo (L-) (meth)amphetamine from human K2EDTA plasma. This paper outlines the development and validation of a method that includes the addition of internal standard and a two-step liquid-liquid extraction to remove the analytes from human K2EDTA plasma by triple quadrupole mass spectrometry (LC-MS/MS). The assay was validated according …


Expansion On The Use Of The Novel Compound, Elp-004, Using A Mycobacterium Tuberculosis Experimentation Model, Kendyl Marie Berry Jan 2023

Expansion On The Use Of The Novel Compound, Elp-004, Using A Mycobacterium Tuberculosis Experimentation Model, Kendyl Marie Berry

Graduate Theses, Dissertations, and Problem Reports (ETD)

Osteoarticular tuberculosis (OAT) is a bone degenerative disease that results in bone erosion, joint effusion, joint swelling, and sometimes, nerve compression. OAT occurs from the hematogenous dissemination of Mycobacterium tuberculosis (Mtb) bacilli spreading from the primary site of infection to the bones and joints; the primary site of infection tends to be the lungs as pulmonary tuberculosis infections are the most common. OAT can occur as the result of an active or latent infection. Latent infections result in OAT when bacilli are able to escape granulomas. The incidence of OAT is not as high as pulmonary infections, making up about …


Acceptability, Feasibility And Preliminary Efficacy Of Low-Moderate Intensity Constraint Induced Aphasia Therapy And Multi-Modality Aphasia Therapy In Chronic Aphasia After Stroke, John E. E. Pierce, Robyn Ohalloran, Leanne Togher, Lyndsey Nickels, David Copland, Erin Godecke, Marcus Meinzer, Tapan Rai, Dominique A. Cadilhac, Joosup Kim, Melanie Hurley, Abby Foster, Marcella Carragher, Cassie Wilcox, Gillian Steel, Miranda L. Rose Jan 2023

Acceptability, Feasibility And Preliminary Efficacy Of Low-Moderate Intensity Constraint Induced Aphasia Therapy And Multi-Modality Aphasia Therapy In Chronic Aphasia After Stroke, John E. E. Pierce, Robyn Ohalloran, Leanne Togher, Lyndsey Nickels, David Copland, Erin Godecke, Marcus Meinzer, Tapan Rai, Dominique A. Cadilhac, Joosup Kim, Melanie Hurley, Abby Foster, Marcella Carragher, Cassie Wilcox, Gillian Steel, Miranda L. Rose

Research outputs 2022 to 2026

Background: High-intensity Constraint-Induced Aphasia Therapy Plus (CIAT-Plus) and Multi-Modality Aphasia Therapy (M-MAT) are effective interventions for chronic post-stroke aphasia but challenging to provide in clinical practice. Providing these interventions may be more feasible at lower intensities, but comparative evidence is lacking. We therefore explored feasibility, acceptability, and preliminary efficacy of the treatments at a lower intensity. Methods: A multisite, single-blinded, randomized Phase II trial was conducted within the Phase III COMPARE trial. Groups of participants with chronic aphasia from the usual care arm of the COMPARE trial were randomized to M-MAT or CIAT-Plus, delivered at the same dose as the …


Leukocyte Surface Biomarkers Implicate Deficits Of Innate Immunity In Sporadic Alzheimer's Disease, Xin Huang, Yihan Li, Christopher Fowler, James D. Doecke, Yen Ying Lim, Candace Drysdale, Vicky Zhang, Keunha Park, Brett Trounson, Kelly Pertile, Rebecca Rumble, John W. Pickering, Robert A. Rissman, Floyd Sarsoza, Sara Abdel-Latif, Yong Lin, Vincent Doré, Victor Villemagne, Christopher C. Rowe, Jurgen Fripp, Ralph Martins, James S. Wiley, Paul Maruff, Jacobo E. Mintzer, Colin L. Masters, Ben J. Gu Jan 2023

Leukocyte Surface Biomarkers Implicate Deficits Of Innate Immunity In Sporadic Alzheimer's Disease, Xin Huang, Yihan Li, Christopher Fowler, James D. Doecke, Yen Ying Lim, Candace Drysdale, Vicky Zhang, Keunha Park, Brett Trounson, Kelly Pertile, Rebecca Rumble, John W. Pickering, Robert A. Rissman, Floyd Sarsoza, Sara Abdel-Latif, Yong Lin, Vincent Doré, Victor Villemagne, Christopher C. Rowe, Jurgen Fripp, Ralph Martins, James S. Wiley, Paul Maruff, Jacobo E. Mintzer, Colin L. Masters, Ben J. Gu

Research outputs 2022 to 2026

Introduction:

Blood-based diagnostics and prognostics in sporadic Alzheimer's disease (AD) are important for identifying at-risk individuals for therapeutic interventions.

Methods:

In three stages, a total of 34 leukocyte antigens were examined by flow cytometry immunophenotyping. Data were analyzed by logistic regression and receiver operating characteristic (ROC) analyses.

Results:

We identified leukocyte markers differentially expressed in the patients with AD. Pathway analysis revealed a complex network involving upregulation of complement inhibition and downregulation of cargo receptor activity and Aβ clearance. A proposed panel including four leukocyte markers – CD11c, CD59, CD91, and CD163 – predicts patients’ PET Aβ status with an …


Locally Performed Postoperative Circulating Tumour Dna Testing Performed During Routine Clinical Care To Predict Recurrence Of Colorectal Cancer, Ryan Cohen, Aaron Beasley, Melanie Mccoy, Cameron Platell, Katie Meehan, Elin Gray, Kathy Fuller Jan 2023

Locally Performed Postoperative Circulating Tumour Dna Testing Performed During Routine Clinical Care To Predict Recurrence Of Colorectal Cancer, Ryan Cohen, Aaron Beasley, Melanie Mccoy, Cameron Platell, Katie Meehan, Elin Gray, Kathy Fuller

Research outputs 2022 to 2026

Background: Identifying patients at high risk for colorectal cancer recurrence is essential for improving prognosis. In the postoperative period, circulating tumour DNA (ctDNA) has been demonstrated as a significant prognostic indicator of recurrence. These results have been obtained under the strict rigours of clinical trials, but not validated in a real-world setting using in-house testing. We report the outcomes of locally performed postoperative ctDNA testing conducted during routine clinical care and the association with the recurrence of colorectal cancer. Methods: We recruited 36 consecutive patients with newly diagnosed colorectal cancer between 2018 and 2020. Postoperative plasma samples were collected at …


Enhancing Health Data Representation For Older Adults: Unlocking Opportunities, Peterson Jean Jan 2023

Enhancing Health Data Representation For Older Adults: Unlocking Opportunities, Peterson Jean

Academic Posters Collection

The prevalence of off-the-shelf wearable devices increases the monitoring and measurement of critical physiological parameters like activity, sleep, heart rate, and blood pressure. However, the accessibility of health data representations poses challenges for older adults, who often struggle to understand the criticality of their own health data without assistance. This poster highlights the challenges older adults face in accessing their health data from wearable technologies, specifically focusing on data representations.

To address these challenges, it proposes a methodology that involves a heuristic evaluation of existing data representations with experts and accessibility studies with older adults using a mixed methods approach …


An Updated Systematic Review Of Stroke Clinical Practice Guidelines To Inform Aphasia Management, Bridget Burton, Megan Isaacs, Emily Brogan, Kirstine Shrubsole, Monique F. Kilkenny, Emma Power, Erin Godecke, Dominique A. Cadilhac, David Copland, Sarah J. Wallace Jan 2023

An Updated Systematic Review Of Stroke Clinical Practice Guidelines To Inform Aphasia Management, Bridget Burton, Megan Isaacs, Emily Brogan, Kirstine Shrubsole, Monique F. Kilkenny, Emma Power, Erin Godecke, Dominique A. Cadilhac, David Copland, Sarah J. Wallace

Research outputs 2022 to 2026

Background: Aphasia is a common consequence of stroke, and people who live with this condition experience poor outcomes. Adherence to clinical practice guidelines can promote high-quality service delivery and optimize patient outcomes. However, there are currently no high-quality guidelines specific to post-stroke aphasia management. Aims: To identify and evaluate recommendations from high-quality stroke guidelines that can inform aphasia management. Summary of review: We conducted an updated systematic review in accordance with PRISMA guidelines to identify high-quality clinical guidelines published between January 2015 and October 2022. Primary searches were performed using electronic databases: PubMed, EMBASE, CINAHL, and Web of Science. Gray …