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Articles 841 - 870 of 1369

Full-Text Articles in Analytical, Diagnostic and Therapeutic Techniques and Equipment

Literature Review: Incidentalomas In Emergency Medicine - How Often Are They Reported And Are Patients Informed?, Mohammad Rattu, James Espinosa, Alan Lucerna, James Lee May 2022

Literature Review: Incidentalomas In Emergency Medicine - How Often Are They Reported And Are Patients Informed?, Mohammad Rattu, James Espinosa, Alan Lucerna, James Lee

Rowan-Virtua Research Day

The purpose of this proposed study is to look at the rate of incidental findings on CT scan in a community hospital setting, as well as to look at the rate of documentation of communication of the findings to the patient and referral for follow-up to primary care or to a specialty follow-up.


Management Of Late-Stage Ewingoid Dedifferentiated Liposarcoma Of The Spermatic Cord With Emergent Complications: A Case Report, Raeann Dalton, Abdullah Junayed, Brian Thomas, Young Son, Megan Donlick, Kathryn Goettle, Lance Earnshaw, Thomas Mueller May 2022

Management Of Late-Stage Ewingoid Dedifferentiated Liposarcoma Of The Spermatic Cord With Emergent Complications: A Case Report, Raeann Dalton, Abdullah Junayed, Brian Thomas, Young Son, Megan Donlick, Kathryn Goettle, Lance Earnshaw, Thomas Mueller

Rowan-Virtua Research Day

Liposarcoma (LS), a malignant tumor of adipose origin, is the most common soft tissue sarcoma (STS), and can develop within any soft tissue. It rarely occurs in the paratesticular region, and accounts for 3-7% of spermatic cord tumors. Dedifferentiated liposarcoma (DDLS) and well-differentiated liposarcoma (WDLS) account for two of the five subtypes of LS, with dedifferentiation occurring in 20% of cases. There have been 66 cases of DDLS of the spermatic cord reported to date, but none present with a 22/22q trisomy without the fusion or rearrangement that commonly produces these aggressive tumors.

Accurate diagnosis of LS of the spermatic …


Nanoparticles For Biomedical Applications, Joseph Kim May 2022

Nanoparticles For Biomedical Applications, Joseph Kim

Dissertations and Theses (Open Access)

This thesis presents development and evaluation of the potential of three new nanoparticles for biomedical applications. With the rapid growth of the field of nanoscience, researchers have explored developing nanoparticles for various biomedical applications, including imaging, therapy, and drug delivery. This thesis demonstrates the development of two C­60 fullerene based nanoparticles and one boron based nanoparticle to answer key questions related to their biological potential.

In the first part of the thesis, we describe synthesis and characterization of a pure boron nanoparticle containing asolectin phospholipid-based liposome construct prepared using a water-in-oil emulsion method, as a novel alternative agent for …


Increasing Colorectal Cancer Screening Adherence: A Scoping Review, Megan E. Billingsley Bsn, Rn, Tiameria T. Ford Bsn, Rn, Mikayla E. Vican Bsn, Rn, Diana Dedmon Dnp, Aprn, Fnp-Bc Apr 2022

Increasing Colorectal Cancer Screening Adherence: A Scoping Review, Megan E. Billingsley Bsn, Rn, Tiameria T. Ford Bsn, Rn, Mikayla E. Vican Bsn, Rn, Diana Dedmon Dnp, Aprn, Fnp-Bc

Doctor of Nursing Practice Projects

Purpose/Background Colorectal cancer (CRC) is the second leading cause of cancer-related deaths in the United States. Rates have steadily increased in recent years due to high rates of obesity, smoking, and sedentary lifestyles. Screening for the disease can lead to early detection and reduced morbidity/mortality, yet screening rates remain low. Existing literature is extensive in discussing methods to increase CRCS adherence; therefore, a scoping review allows for increased understanding of barriers to CRCS and how to address those barriers to increase screening compliance.

Methods A literature search was completed from September 2020 to October 2021. Multiple databases were used, including …


Using Machine Learning To Recognize Chronic Rhinosinusitis, Irene Liu '23 Apr 2022

Using Machine Learning To Recognize Chronic Rhinosinusitis, Irene Liu '23

Student Publications & Research

Chronic Rhinosinusitis (CRS) is a nasal disease characterized by the inflammation of the mucosa and paranasal sinuses with a duration of at least 12 consecutive weeks. So, to diagnose CRS, one needs to keep a record of their symptoms for ~12 weeks before they are recommended to get a tomography which will allow physicians to classify them as a patient with CRS or without. This is a timely and costly process; thus, machine learning should be used to speed the process up. Since patients with CRS have more obstructed noses, the sound produced should be different than an individual without …


Stroke Network Of Wisconsin (Snow) Scale Predicts Large Vessel Occlusion Stroke In The Prehospital Setting, Kessarin Panichpisal, Sarah Erpenbeck, Paul Vilar, Reji P. Babygirija, Maharaj Singh, M. Riccardo Colella, Richard A. Rovin Apr 2022

Stroke Network Of Wisconsin (Snow) Scale Predicts Large Vessel Occlusion Stroke In The Prehospital Setting, Kessarin Panichpisal, Sarah Erpenbeck, Paul Vilar, Reji P. Babygirija, Maharaj Singh, M. Riccardo Colella, Richard A. Rovin

Journal of Patient-Centered Research and Reviews

Purpose: In previous trials, the Stroke Network of Wisconsin (SNOW) scale accurately predicted large vessel occlusion (LVO) stroke in the hospital setting. This study evaluated SNOW scale performance in the prehospital setting and its ability to predict LVO or distal medium vessel occlusion (DMVO) in patients suspected of having acute ischemic stroke (AIS), a scenario in which transport time to an endovascular treatment-capable facility (ECSC) is critical.

Methods: All potential AIS patients with last-known-well time of ≤ 24 hours were assessed by Milwaukee County Emergency Medical Services for LVO using SNOW. Patients with a positive SNOW score were transferred to …


Impact Of Spontaneous Breathing Trials On Reducing Ventilator-Associated Pneumonia In Adult Intubated Patients: A Scoping Review, Jireh R. Johnson Bsn, Rn, Hamzha Aysheh Bsn, Rn, Keianna Luckett Bsn, Rn, Margaret Harvey Phd, Aprn, Acnp-Bc, Chfn Apr 2022

Impact Of Spontaneous Breathing Trials On Reducing Ventilator-Associated Pneumonia In Adult Intubated Patients: A Scoping Review, Jireh R. Johnson Bsn, Rn, Hamzha Aysheh Bsn, Rn, Keianna Luckett Bsn, Rn, Margaret Harvey Phd, Aprn, Acnp-Bc, Chfn

Doctor of Nursing Practice Projects

Purpose/Background For ventilated patients in the intensive care unit, ventilator-associated pneumonia (VAP) is a major source of morbidity. It is difficult to diagnose due to many of the diagnostic criteria being subjective, its clinical signs that are broad, and its association with various respiratory disorders. Hospitals have developed varying ventilator bundles in expectation to prevent the incidence of Ventilator-associate pneumonia. We performed scoping review to determine the impact of spontaneous breathing trials (SBT) on reducing VAP.

Methods From August to November of 2021, using the MEDLINE, ScienceDirect, and Scopus databases and MeSH search terms, we identified over 20,000 articles containing …


Comparison Of Survival Rates Between Two Cardiopulmonary Resuscitation Protocols And The Association Of Crew Consistency, Stacey L. Parrish, Lori Kupczynski, Pradeep Vanguri Mar 2022

Comparison Of Survival Rates Between Two Cardiopulmonary Resuscitation Protocols And The Association Of Crew Consistency, Stacey L. Parrish, Lori Kupczynski, Pradeep Vanguri

Internet Journal of Allied Health Sciences and Practice

Background: Cardiac arrest is a life-altering event that requires swift, coordinated actions from numerous individuals for patient survival. Although return of spontaneous circulation is the goal of every emergency medical service agency, survival rates continue to be low due to many factors. Many variables are out of direct control of emergency medical service agencies, but some, such as protocol development and personnel training, are well within their power. Purpose: The purpose of this mixed-methods study was to examine the new HP-CPR protocol implemented by a large southeastern urban fire rescue department to see if changes to existing protocol assisted, in …


Succinic Semialdehyde Dehydrogenase Deficiency (Ssadhd): Qualitative Needs Assessment For Patients With A Rare Neurological Disorder, Cassandra Bovee, Kayla Woodring Mar 2022

Succinic Semialdehyde Dehydrogenase Deficiency (Ssadhd): Qualitative Needs Assessment For Patients With A Rare Neurological Disorder, Cassandra Bovee, Kayla Woodring

Annual Research Symposium

No abstract provided.


Cbct In Clinical Practice, Tarunjeet Pabla Bds, Dmd, Ms, Dip. Abomr, Hugo C. Campos Dds, Dmd, Mds, Dip. Abomr, Aruna Ramesh Bds, Dmd, Ms, Dip. Abomr Mar 2022

Cbct In Clinical Practice, Tarunjeet Pabla Bds, Dmd, Ms, Dip. Abomr, Hugo C. Campos Dds, Dmd, Mds, Dip. Abomr, Aruna Ramesh Bds, Dmd, Ms, Dip. Abomr

The Journal of the Michigan Dental Association

This feature explores the integration of Cone Beam Computed Tomography (CBCT) into dental practice, offering guidelines for best practices. Introduced in 2001, CBCT revolutionized dental radiography, impacting various clinical areas. The article emphasizes the need for clinicians to comprehend CBCT technology, its benefits, and potential risks. It delves into CBCT imaging considerations, technical parameters (Field of View, Voxel Size, Spatial and Contrast Resolution), image viewing, artifacts, machine calibration, and service. Addressing radiation dose, risks, and protection, the article outlines decision-making for 2D vs. 3D imaging. It underscores the responsibility of interpreting CBCT images, legal considerations, return on investment, and the …


Open Your Eyes To 3d Imaging, Lea Al Matny Dds, Ms Mar 2022

Open Your Eyes To 3d Imaging, Lea Al Matny Dds, Ms

The Journal of the Michigan Dental Association

This cover feature illuminates the transformative role of cone beam computed tomography (CBCT) in dental diagnostics and treatment planning. As CBCT evolves from specialized to commonplace usage, its impact on various dental specialties, including oral surgery, periodontics, orthodontics, and general dentistry, becomes apparent. The article underscores the necessity of understanding CBCT's fundamental concepts and emphasizes the importance of customized imaging protocols tailored to patients' needs. Comprehensive evaluation of CBCT scans reveals anatomical variations, aids in detecting periapical pathosis, visualizing root fractures, assessing external cervical root resorption, and contributes to airway analysis. Moreover, the article explores CBCT's expanding role beyond implant …


A Case Of Cryptomenorrhea Presenting As - Acute Abdominal Pain, Udisha Arya Ms., Ritu Mittal Arya Dr. Feb 2022

A Case Of Cryptomenorrhea Presenting As - Acute Abdominal Pain, Udisha Arya Ms., Ritu Mittal Arya Dr.

Digital Journal of Clinical Medicine

BACKGROUND:

The transverse vaginal septum is a congenital Mullerian abnormality caused due to improper fusion of the Müllerian ducts with urogenital sinus. It is classified as complete or incomplete and obstructive or non-obstructive and occurs at various levels such as superior vaginal (46%), mid-vaginal(40%) and inferior vaginal(14%). Transverse vaginal septum is a rare condition with incidence varying from 1:2100 to 1:72,000. The condition is difficult to manage often due to delayed diagnosis and is usually diagnosed when hematocolpos lead to symptoms due to an expanding pelvic mass

CASE DESCRIPTION:

A 14-year-old female adolescent presented with a history of acute pain …


Managing Concurrent Discitis And Epidural Abscess Following Tfesi Arising From Unlikely Bacterial Species: The Importance Of Post-Procedure Education, Adlai Pappy, Robert Louis, Vinita Singh Feb 2022

Managing Concurrent Discitis And Epidural Abscess Following Tfesi Arising From Unlikely Bacterial Species: The Importance Of Post-Procedure Education, Adlai Pappy, Robert Louis, Vinita Singh

Advances in Clinical Medical Research and Healthcare Delivery

Introduction:

Transforaminal epidural steroid injection (TFESI) can provide pain relief when patients’ radicular pain is refractory to medication and physical therapy. However, it is important that clinicians understand potential signs and symptoms of TFESI complications to prevent long-term sequelae. Literature has not documented both discitis and an epidural abscess concurrently following a lumbar TFESI.

Case:

We present a patient with stage 3c melanoma on the right lower extremity (RLE) with worsening lower extremity and foot pain. The pain was refractory to his current medication regimen of Gabapentin, and he wanted an alternative to opioids. A right L2-L5 TFESI was …


Applications Of Unsupervised Machine Learning In Autism Spectrum Disorder Research: A Review, Chelsea Parlett-Pelleriti, Elizabeth Stevens, Dennis R. Dixon, Erik J. Linstead Jan 2022

Applications Of Unsupervised Machine Learning In Autism Spectrum Disorder Research: A Review, Chelsea Parlett-Pelleriti, Elizabeth Stevens, Dennis R. Dixon, Erik J. Linstead

Engineering Faculty Articles and Research

Large amounts of autism spectrum disorder (ASD) data is created through hospitals, therapy centers, and mobile applications; however, much of this rich data does not have pre-existing classes or labels. Large amounts of data—both genetic and behavioral—that are collected as part of scientific studies or a part of treatment can provide a deeper, more nuanced insight into both diagnosis and treatment of ASD. This paper reviews 43 papers using unsupervised machine learning in ASD, including k-means clustering, hierarchical clustering, model-based clustering, and self-organizing maps. The aim of this review is to provide a survey of the current uses of …


Prevalence Of Endocrine Disorders Among 6078 Individuals With Down Syndrome In The United States, Anne Rivelli, Veronica Fitzpatrick, Danielle Wales, Laura Chicoine, Gengjie Jia, Andrey Rzhetsky, Brian Chicoine Jan 2022

Prevalence Of Endocrine Disorders Among 6078 Individuals With Down Syndrome In The United States, Anne Rivelli, Veronica Fitzpatrick, Danielle Wales, Laura Chicoine, Gengjie Jia, Andrey Rzhetsky, Brian Chicoine

Journal of Patient-Centered Research and Reviews

Findings from a recent study describing prevalence of common disease conditions in the largest documented cohort of individuals with Down syndrome (DS) in the United States strongly suggested significant disparity in endocrine disorders among these individuals when compared with age- and sex-matched individuals without DS. This retrospective, descriptive study is a follow-up report documenting prevalence of 21 endocrine disorder conditions, across 28 years of data, from 6078 individuals with DS and 30,326 age- and sex-matched controls, abstracted from electronic medical records within a large integrated health system. Overall, individuals with DS experienced higher prevalence of adrenal insufficiency and Addison’s disease; …


Seroprevalence Of Covid-19 Igg Antibody In Resident And Fellow Physicians In Milwaukee, Wisconsin: Analysis Of A Cross-Sectional Survey, Dennis J. Baumgardner, Alexander Schwank, Jessica J. F. Kram, Wilhelm Lehmann, Jacob Bidwell, Tricia La Fratta, Kenneth Copeland Jan 2022

Seroprevalence Of Covid-19 Igg Antibody In Resident And Fellow Physicians In Milwaukee, Wisconsin: Analysis Of A Cross-Sectional Survey, Dennis J. Baumgardner, Alexander Schwank, Jessica J. F. Kram, Wilhelm Lehmann, Jacob Bidwell, Tricia La Fratta, Kenneth Copeland

Journal of Patient-Centered Research and Reviews

Purpose: Medical trainees are likely at differential risk of exposure to COVID-19 per respective clinical activity. We sought to determine the seroprevalence of COVID-19 antibody (Ab) among resident and fellow physicians with varying degrees of exposure to COVID-19.

Methods: A cross-sectional study of Milwaukee-based resident and fellow physicians, encompassing December 2019–June 2020, was conducted. Relevant variables of interest were ascertained by survey and payroll data, and Abbott ARCHITECT Ab test (index cut-off of ≥ 1.4) was performed. Descriptive statistics were generated, with 95% CI calculated for the study’s primary outcome of seroprevalence.

Results: Among survey respondents (92 of 148, 62%), …


Toward A Multimodal Computer-Aided Diagnostic Tool For Alzheimer’S Disease Conversion, Danilo Pena, Jessika Suescun, Mya Schiess, Timothy M. Ellmore, Luca Giancardo, Alzheimer’S Disease Neuroimaging Initiative Jan 2022

Toward A Multimodal Computer-Aided Diagnostic Tool For Alzheimer’S Disease Conversion, Danilo Pena, Jessika Suescun, Mya Schiess, Timothy M. Ellmore, Luca Giancardo, Alzheimer’S Disease Neuroimaging Initiative

Publications and Research

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder. It is one of the leading sources of morbidity and mortality in the aging population AD cardinal symptoms include memory and executive function impairment that profoundly alters a patient’s ability to perform activities of daily living. People with mild cognitive impairment (MCI) exhibit many of the early clinical symptoms of patients with AD and have a high chance of converting to AD in their lifetime. Diagnostic criteria rely on clinical assessment and brain magnetic resonance imaging (MRI). Many groups are working to help automate this process to improve the clinical workflow. Current …


Dermatologic Manifestations Of Rheumatic Disease: Cutaneous Manifestations Of Sarcoidosis, Sarah Shapiro, Sindhuja Koppu, Mavra Masood, Beth Rubinstein, Huzaefah Syed Jan 2022

Dermatologic Manifestations Of Rheumatic Disease: Cutaneous Manifestations Of Sarcoidosis, Sarah Shapiro, Sindhuja Koppu, Mavra Masood, Beth Rubinstein, Huzaefah Syed

Open and Affordable Course Content at VCU

No abstract provided.


Eliminating Repetitive Cbc Orders On The Resident Inpatient Service At Orlando Vahcs, Zara Bashir, Jorge Rodriguez, Ashlee Sidhu, Feras Al-Moussally, Brian Murr, Jorge Restrepo Jan 2022

Eliminating Repetitive Cbc Orders On The Resident Inpatient Service At Orlando Vahcs, Zara Bashir, Jorge Rodriguez, Ashlee Sidhu, Feras Al-Moussally, Brian Murr, Jorge Restrepo

North Florida Division GME Research Day 2022

No abstract available.


Improving Appropriate Utilization Of Telemetry: Quality Improvement Project, Carlos Vargas, Haris Ahmed, Kashmala Khan, Francis Dimtri, Ahmed Mahmood, Jeffery S. Durbin, Christel Cuevas, Thomas Alexander Jan 2022

Improving Appropriate Utilization Of Telemetry: Quality Improvement Project, Carlos Vargas, Haris Ahmed, Kashmala Khan, Francis Dimtri, Ahmed Mahmood, Jeffery S. Durbin, Christel Cuevas, Thomas Alexander

Gulf Coast Division GME Research Day 2022

No abstract provided.


Lady In Red: A Fatal Case Of Dress, Hytham Rashid, Ndifreke Ekpa, Tusharkumar Pansuriya, Mir Ali Sadat Jan 2022

Lady In Red: A Fatal Case Of Dress, Hytham Rashid, Ndifreke Ekpa, Tusharkumar Pansuriya, Mir Ali Sadat

Gulf Coast Division GME Research Day 2022

No abstract provided.


Contrast-Induced Encephalopathy Following Diagnostic Coronary Angiography, Hytham Rashid, Andrew Good, Jonathan Brown, Tusharkumar Pansuriya, Alan Fisher Covin, Mir Ali Sadat Jan 2022

Contrast-Induced Encephalopathy Following Diagnostic Coronary Angiography, Hytham Rashid, Andrew Good, Jonathan Brown, Tusharkumar Pansuriya, Alan Fisher Covin, Mir Ali Sadat

Gulf Coast Division GME Research Day 2022

No abstract provided.


Cesarean Scar Ectopic Pregnancy: A Case Report, Paola Ortiz-Rodriguez, Romany Gawargious Hana Jan 2022

Cesarean Scar Ectopic Pregnancy: A Case Report, Paola Ortiz-Rodriguez, Romany Gawargious Hana

Gulf Coast Division GME Research Day 2022

No abstract provided.


A Clinical Study Of Venereal And Non Venereal Genital Dermatoses In Women, Lakkireddygari Sujana, Savitha L. Beergouder, Alekhya Rallapalli, Prasanthi Chidipudi, Sujatha Alla Jan 2022

A Clinical Study Of Venereal And Non Venereal Genital Dermatoses In Women, Lakkireddygari Sujana, Savitha L. Beergouder, Alekhya Rallapalli, Prasanthi Chidipudi, Sujatha Alla

Engineering Management & Systems Engineering Faculty Publications

Background: Any genital lesion or related symptoms are erroneously considered to be sexually transmitted as it is the most covered regions of the body and seems truly to be a forgotten pelvic organ it is the significant and important group of dermatological conditions may be associated with considerable morbidity, discomfort, and embarrassment. The most common conditions seen in a Dermatology Clinic are vulvar dermatoses, which comprise of lichen sclerosis, lichen planus, vulvar eczema, and psoriasis. Other conditions such as vulvar pain syndromes, vulvar disorders associated with systemic diseases, and blistering diseases are also seen.

Materials and Methods: This was a …


Generalization Of Net Benefit Of Diagnostic Tests Into Multi-Stage Clinical Conditions: A Collapsing Approach, Ferdous Ahmed Jan 2022

Generalization Of Net Benefit Of Diagnostic Tests Into Multi-Stage Clinical Conditions: A Collapsing Approach, Ferdous Ahmed

College of Graduate Studies: Theses & Dissertations

Evaluating diagnostic tests based on benefit-risk involves both the tests’ accuracy and the clinical implications of the diagnostic errors. Diagnostic tests are commonly classified into two stages: either positive or negative for a clinical condition (diseased or non-diseased). However, some diseases have more than two stages, such as Alzheimer’s. In diseases with more than two stages, the benefits and risks of the clinical consequences could differ from stage to stage. I could not find any investigations to account for the difference in benefits and risks of tests with more than two stages in the literature. The benefit to cost values …


Suspected Blow To The Chest? Investigate It!, Parisa Biazar, Catherine Mitchell, David I. Rosenberg Jan 2022

Suspected Blow To The Chest? Investigate It!, Parisa Biazar, Catherine Mitchell, David I. Rosenberg

South Atlantic Division GME Research Day 2022

No abstract provided.


Implementation Of Standardized Protocols For Office Blood Pressure Measurement, Steven Nevers, Alice Tran, Carol Gambrill, Anush Pillai Jan 2022

Implementation Of Standardized Protocols For Office Blood Pressure Measurement, Steven Nevers, Alice Tran, Carol Gambrill, Anush Pillai

Gulf Coast Division GME Research Day 2022

No abstract provided.


Neuromotor Changes In Participants With A Concussion History Can Be Detected With A Custom Smartphone App, Christopher K. Rhea, Masahiro Yamada, Nikita A. Kuznetsov, Jason T. Jakiela, Chanel T. Lojacono, Scott E. Ross, F. J. Haran, Jason M. Bailie, W. Geoffrey Wright Jan 2022

Neuromotor Changes In Participants With A Concussion History Can Be Detected With A Custom Smartphone App, Christopher K. Rhea, Masahiro Yamada, Nikita A. Kuznetsov, Jason T. Jakiela, Chanel T. Lojacono, Scott E. Ross, F. J. Haran, Jason M. Bailie, W. Geoffrey Wright

Rehabilitation Sciences Faculty Publications

Neuromotor dysfunction after a concussion is common, but balance tests used to assess neuromotor dysfunction are typically subjective. Current objective balance tests are either cost- or space-prohibitive, or utilize a static balance protocol, which may mask neuromotor dysfunction due to the simplicity of the task. To address this gap, our team developed an Android-based smartphone app (portable and cost-effective) that uses the sensors in the device (objective) to record movement profiles during a stepping-in-place task (dynamic movement). The purpose of this study was to examine the extent to which our custom smartphone app and protocol could discriminate neuromotor behavior between …


Altitude Illness, Kali Hepner Jan 2022

Altitude Illness, Kali Hepner

Capstone Showcase

With an increasing number of individuals traveling to high altitudes, it is important to address the risk these individuals face of developing altitude related illnesses. An example of high altitude related illness might be the elevation transition of travelers flying into Denver, Colorado (1,673 m) with the intention to then drive up to Rocky Mountain National Park’s Alpine Visitor Center (3,595 m) in the same day. This poses increased risk of unacclimatized visitors experiencing altitude illness in remote areas of the national park. This poster summarizes the diagnosis, prevention, and treatment of altitude illnesses so that clinicians and travelers may …


Management Of Adult Growth Hormone Deficiency Related To Hypopituitarism, Kellie Jamin Jan 2022

Management Of Adult Growth Hormone Deficiency Related To Hypopituitarism, Kellie Jamin

Capstone Showcase

The treatment of growth hormone deficiency (GHD) is well-established in childhood but less understood in adults, given the more complex role that growth hormone (GH) assumes in this population. Decreased functionality of the pituitary gland, otherwise known as hypopituitarism, can present with an isolated GHD in adulthood, which may result from a number of factors including neoplasm, ischemia, infection, traumatic injury, or systemic disease. Adult GHD may be definitively diagnosed with a stimulation test, the insulin tolerance test (ITT) being the study of choice. With a positive ITT, the disorder can be treated with growth hormone replacement therapy (GHRT), which …