Alternative and Complementary Medicine Commons^™

Anti-Inflammatory And Immune-Modulating Effects Of Rice Callus Suspension Culture And Blueberry Extract On An In-Vitro Inflammatory Bowel Disease Model, Kyle Michael Driscoll

Dissertations, Master's Theses and Master's Reports

Rice Callus Suspension Culture (RCSC) has been shown to exhibit potent anticancer activity in vitro. In this study we aimed to investigate the anti-inflammatory and immune-modulating properties of RCSC on three inflamed normal colon epithelial cell lines, InEpC, NCM 356, and CCD 841 CoN. As a comparative, we additionally analyzed the anti-inflammatory effects of Highbush blueberries on two inflamed colon cell cultures, NCM 356 and CCD 841 CoN. Furthermore, we sought to characterize the bioactive compounds in RCSC responsible for anti-cancer, anti-inflammatory, and immune-modulating effects. This work will be an essential starting point for understanding and identifying possible bioactive …

The Experience Of Qigong Among Women Cancer Survivors, Jennifer Sveund

Antioch University Dissertations & Theses

Research has shown that qigong can be beneficial for a variety of health related conditions; However, evidence suggests that in the United States, a lack of well designed clinical trials limits the efficacy of qigong in the context of cancer treatment. Research has indicated that careful consideration should be given to the design of randomized control trials using qigong due to the conflicting philosophical methodologies. In the United States, qigong has been under investigated, particularly lacking are qualitative inquiries into qigong use and cancer survivorship. This study is an interpretative phenomenological inquiry that sought to understand women’s experience of qigong …

Polyphenols Content And Antioxidant Activity Of Artemisia Sieversiana Willd. In Western Pamir, Gulazor Miravalova, Sh. Kurbonbekova, Sh. Satorov, Akobir Mirzorahimov, Dovudsho Navruzshoev, Vyacheslav Dushenkov, M. Vakhidova

Publications and Research

Polyphenols content and antioxidant activity in Artemisia sieversiana Willd. were investigated in relation to the altitude of the plant growth in the Western Pamir region. Antioxidant activity generally correlated with the polyphenols content. However, no significant association was found between an altitude of the sample collection and polyphenols content or antioxidant activity.

Folate As An Adjunctive Therapy For Treatment Resistant Depression, Katherine Mcfarland

Physician Assistant Scholarly Project Posters

Numerous medications are available to treat depression, yet many patients do not achieve remission or recovery of their symptoms with traditional therapies alone. Folate supplementation has been shown to be beneficial in the treatment of depression when used in addition to traditional prescription therapy. A literature review was conducted to determine the effect of low folate levels on depression and if supplementation with either folic acid or L-methylfolate benefits this patient population. Key search terms including folate, folate deficiency, methylfolate, nutrition, and depression were used to perform searches of multiple databases and journals including PubMed, CINAHL, PsycInfo, and the American …

Prolotherapy: Applications, Mechanism Of Action, Controversy And Evidence, Boris M. Davydov

Physician Assistant Scholarly Project Posters

Merriam-Webster defines prolotherapy (PROLO) as “an alternative therapy for treating musculoskeletal pain that involves injection of irritant substance (as dextrose) into a ligament or tendon to promote the growth of new tissue”. Experimental research and multiple clinical trials have generated evidence suggesting that PROLO is effective at treating a variety of musculoskeletal conditions, including tendinopathies, joint instability and ligament laxity. PROLO may also hold a potential to delay or avoid joint replacement and rotator cuff surgeries. Further research is needed to demonstrate the therapeutic effect of PROLO unequivocally.

Curcumin And Fish Oil: Potential Alternative Or Adjunctive Treatments To Nsaids And Immune Modulating Medications For The Treatment Of Chronic Inflammation, Vicki Andvik

Physician Assistant Scholarly Project Posters

The aim of the present review is to evaluate the efficacy and safety of curcumin and fish oil as alternative or adjuvant treatments to NSAIDs and immune modulating medications for the treatment of chronic inflammation.

An online search of CINAHL, PubMed, Cochrane and Alt Healthwatchdatabases was conducted. It was limited to peer-reviewed articles and clinical trials in academic journals within the last ten years.

Current research suggests that curcumin may be efficacious in the treatment of chronic inflammation. It is generally regarded as safe up to 12 gm/day with mild gastrointestinal effects but poor bioavailability has limited its clinical application. …

Utilization Of Traditional, Complementary And Alternative Medicine And Mental Health Among Patients With Chronic Diseases In Primary Health Care Settings In Cambodia, Siyan Yi, Chanrith Ngin, Sovannary Tuot, Pheak Chhoun, Tyler Fleming, Carinne M. Brody

Background: Coping with chronic illnesses often involves major lifestyle changes that may lead to poor mental health. Furthermore, in order to treat the chronic conditions, many sufferers in Asia turn to traditional, complementary and alternative medicines (TCAM). This study explores prevalence of TCAM use and factors associated with anxiety and depressive symptoms among patients with chronic diseases in Cambodia.

Methods: In 2015, this cross-sectional study was conducted with outpatients receiving treatment and care for chronic diseases in two urban and two rural primary health centers. Every eligible patient was randomly selected at the health centers using a systematic sampling procedure. …

Is Tea Tree Oil Preparation An Effective Topical Therapy For Patients With Msra Colonized Wounds?, Mariah A. Gerald

PCOM Physician Assistant Studies Student Scholarship

OBJECTIVE: The objective of this selective EBM review is to determine whether or not tea tree oil preparation an effective topical therapy for patients with MRSA colonized wounds.

STUDY DESIGN: This review is based on three randomized controlled trials (RCTs) published in 2004,2013, and 2014. These studies compared the efficacy of tea tree oil (TIO) topical preparations in MRSA colonized wounds.

DATA SOURCES: All articles used were published in English, in peer-reviewed journals, and found using PubMed and Cochrane Review databases.

OUTCOMES MEASURED: The efficacy of tea tree oil preparations on MRSA colonized wounds were evaluated …

Is Mindfulness-Based Therapy Effective In Increasing Total Sleep Time In Adults?, Johanna F. Detwiler

PCOM Physician Assistant Studies Student Scholarship

Objective: The objective of this selective evidence based medicine review is to determine whether or not mindfulness-based therapy is effective in increasing total sleep time in adults.

Study design: Review of three randomized controlled trials published in 2011, 2014 and 2015, all English language.

Data source-The three randomized controlled trials that were used in this review were found using PubMed.

Outcomes measured: Total sleep time, sleep onset latency, wake after sleep onset, number of awakenings, time in bed, subjective sleep quality, sleep duration, habitual sleep efficiency, sleep disturbances, use of sleep medications, and daytime dysfunction were …

Is Yoga Effective In Preventing Nicotine Cravings During Smoking Cessation In Adults?, George F. Donohue

PCOM Physician Assistant Studies Student Scholarship

No abstract

Is L-Theanine An Effective Treatment For Reducing Anxiety In Patients Ages 18-25?, Nicole Bubes

PCOM Physician Assistant Studies Student Scholarship

Objective: The objective of this selective EBM review is to determine whether or not L-theanine, an amino acid analogue found in green tea leaves, is an effective treatment for reducing anxiety in patients ages 18-25.

Study design: Review of two double-blind, randomized controlled studies and one single-blind, randomized controlled study published in 2007, 2012 and 2013 respectively.

Data sources: PubMed

Outcome(s) measured: Each study measured L-theanine’s ability to reduce acute anxiety with a series of self-report measures assessing acute anxiety and stress, including the Profile of Mood States (POMS), the visual analogue scales (VAS), State-Trait Anxiety …

Is Ginkgo Biloba Effective In Managing The Symptoms Of Adhd And Does It Exhibit Lower Adverse Side Effects As Compared To The Current Standard Of Treatment?, Joshua Meir Alge

PCOM Physician Assistant Studies Student Scholarship

Objective: The objective of this selective evidence based medicine review is to determine whether or not ginkgo biloba is effective in managing the symptoms of ADHD and if it exhibits lower adverse side effects as compared to the current standard of treatment.

Study Design: Systematic review of three English language studies, two of which were randomized, double blind, controlled trials (one positive controlled, one placebo controlled), and one open prospective cohort study, published between 2009-2015.

Data Source: Two randomized, double blind, controlled trials (one positive controlled, one placebo controlled), and one open prospective cohort study. In one …

Are Cams Safe And Effective In Improving Symptoms Of Adult Patients Over The Age Of 18 With Active Crohn Disease?, Amy Pellerito

PCOM Physician Assistant Studies Student Scholarship

Objective: The objective of this selective EBM review is to determine whether or not complimentary and alternative medicines are safe and effective in improving symptoms of adult patients over the age of 18 with active Crohn disease.

Study design: A review of three published, randomized controlled trials (RCTs), one published in 2010, and the second and third in 2014. All English language.

Data source: All 3 RCT’s were found using PubMed.

Outcomes measured: All three studies measured improvement of Crohn disease symptoms through the Crohn Disease Activity Index (CDAI), Hamilton’s Depression Scale (HAMD), the Inflammatory Bowel …

Is The Use Of The Chinese Herbal Medicine, Ningdong Granule, A Safe And Effective Alternative To Haloperidol For The Treatment Of Tic Symptoms In Pediatric Patients With Tourette Syndrome (Ts)?, Vincent Russell

PCOM Physician Assistant Studies Student Scholarship

OBJECTIVE The objective of this selective EBM review is to determine whether the Chinese herbal supplement, Ningdong granule, is a safe and effective alternative to haloperidol for the treatment of tic symptoms in pediatric patients with Tourette Syndrome.

STUDY DESIGN Systematic review of three randomized controlled trials published in 2009, 2010, and 2012.

DATA SOURCES Three randomized controlled trials were obtained using PubMed.

OUTCOMES MEASURED Efficacy of Ningdong granule (NDG) as compared to control groups based on decrease in tic severity and frequency as reported by Yale Global Tic Severity Scale as well as safety, as evidenced by prevalence of …

Association Of Various Concentrations Of Cat's Claw Herb (Uncaria Tomentosa) On Lymphocyte Proliferation And Nitric Oxide Expression: An In-Vitro Study Of Osteoarthritis, Noha Fadlalddin

Dissertations and Theses @ UNI

Uncaria tomentosa, also known as cat’s claw, is an indigenous herb which originates from the Amazon River basin and has proven to be highly effective via case report and limited epidemiological evaluation in the pallative treatment of a number of inflammatory conditions. The herb is particularly preferred on the American market due to its various uses for healing, which provides the impetus for this research. The herb is being used to treat osteoarthritis and claims have been made for its ability to: enhance the repair of deoxyribonucleic acid (DNA), support joint health and improve immune function, enable normal division of …

Po2 Dependence Of Oxygen Consumption In Skeletal Muscle Of Hypertensive And Normotensive Rats, Habiba Shah

Theses and Dissertations

Human essential hypertension affects over 75 million people in the United States, and can lead to death due to its several serious health complications such as hypertension-related cardiovascular disease. The purpose of this research was to understand how hypertension could cause physiological changes to the microcirculation, specifically the PO₂ dependence of oxygen consumption (VO₂) in skeletal muscle of normotensive and hypertensive rats. The Spontaneously Hypertensive Rat (SHR) strain was used as the diseased model, and Wistar-Kyoto (WKY) rats were used as controls to conduct this study. The SHR strain develops hypertension between 5-6 weeks after birth with …

The Characterization Of Chimeric Chaperone Flagrp170 As A Novel Radioprotectant, Tyler L. Nguyen

Theses and Dissertations

Abstract

THE CHARACTERIZATION OF CHIMERIC CHAPERONE FLAGRP170 AS A NOVEL RADIOPROTECTANT

By Tyler Nguyen, M.S.

A thesis submitted in partial fulfillment of the requirements for the degree of Master of Science at Virginia Commonwealth University.

Virginia Commonwealth University, 2017

Major Director: Dr. Xiang-Yang (Shawn) Wang, Ph.D., Professor, Department of Human and Molecular Genetics

Radiation therapy (RT) is restricted by toxic effects on adjacent normal tissue, which limits RT efficacy in cancer treatment. Damage to normal tissue, such as radiosensitive intestine and bone marrow compartments, results in acute radiation damage. To reduce normal tissue injury in the setting of RT, we …

Fish Oil With Higher Dha Content And Voluntary Exercise Decreases Postmenopausal Bone Loss, Jameela Banu, Gabriel Fernandes

School of Integrative Biological & Chemical Sciences (Formerly Dept. of Biology)

There is increasing evidence suggesting that fish oil (FO) decreases bone resorption by reducing osteoclastogenesis and regular exercise (EX) increases bone mass. EX is associated with increasing bone formation. Therefore, the combined effects of FO intake and EX may have additive effects by both increasing bone formation and decreasing bone resorption. To demonstrate this, we studied the effects of FO and EX on the bone of mice after an ovariectomyinduced bone loss.

Twelve months old C57BL/6 female mice were either sham operated or ovariectomized, divided into different dietary and EX group and maintained for 3 months before sacrifice.

The distal …

Shinrin-Yoku (Forest Bathing) And Nature Therapy: A State-Of-The-Art Review, Margaret M. Hansen Edd, Msn, Rn, Reo Jones, Kirsten Tocchini

Nursing and Health Professions Faculty Research and Publications

Background: Current literature supports the comprehensive health benefits of exposure to nature and green environments on human systems. The aim of this state-of-the-art review is to elucidate empirical research conducted on the physiological and psychological effects of Shinrin-Yoku (or Forest Bathing) in transcontinental Japan and China. Furthermore, we aim to encourage healthcare professionals to conduct longitudinal research in Western cultures regarding the clinically therapeutic effects of Shinrin-Yoku and, for healthcare providers/students to consider practicing Shinrin-Yoku to decrease undue stress and potential burnout. Methods: A thorough review was conducted to identify research published with an initial open date range …

Complementary And Alternative Medicine (Cam) And Adolescent Body Mass Index (Bmi): A National Population-Based Study, Laura Y. Defrain Lpn

Williams Honors College, Honors Research Projects

COMPLEMENTARY AND ALTERNATIVE MEDICINE (CAM) AND ADOLESCENT BODY MASS INDEX (BMI): A NATIONAL POPULATION-BASED STUDY

Abstract

Background

Childhood obesity rates in the United States have remained around 17% since the 1990s - this figure translates to an estimated 12.7 million obese children. Maintaining a healthy weight through adolescence may limit subsequent health risks in adulthood. Complementary and alternative medicine (CAM) encompasses a variety of non-pharmacological treatments and lifestyle choices that have been utilized in addition to or in place of typical Western medicine. The relationship between adolescent Body mass index (BMI) and the use of complementary and alternative medicine has …

Efficacy Of Animal-Assisted Therapy Across Pediatric Care Settings: A Systematic Review, Holly Howser, Thomas Dixon, Jessica Nunez

Williams Honors College, Honors Research Projects

With alternative therapies and complementary medicine becoming increasingly popular and supported by research, it is important for healthcare workers to be prepared to encounter and use these therapies in practice. A common problem in the pediatric healthcare setting is stress in patients and families during healthcare treatment. Animal assisted therapy (AAT), more commonly known as pet therapy, is a form of complementary alternative therapy that has been examined in this population. The purpose of this systematic review is to explore the effect of AAT on treatment outcomes in pediatric patients across clinical settings. The methods used to guide this systematic …

Portulaca Oleracea Extract Can Inhibit Nodule Formation Of Colon Cancer Stem Cells By Regulating Gene Expression Of Notch Signal Transduction Pathway, Li Chen

Dissertations, Master's Theses and Master's Reports

The main aim of this study was to investigate the effects of Portulaca oleracea extract on tumor formation in colon cancer stem cells and chemotherapy sensitivity. In addition, this study analyzed the genetic changes within the Notch signal transduction pathway associated with the effects of the extracts. Serum-free cultures of colon cancer cells (HT-29) and HT-29 stem cells were treated with the chemotherapeutic drug 5-FU to assess sensitivity. Injections of the stem cells were also given to BALB/c mice to confirm tumor growth and characteristics. In addition, the effect of different concentrations of P. oleracea extract was tested on the …

Breast Cancer, Mana'olana/Hope, And The Experience Of Native Hawaiian Women, Karla Marie Calumet

Walden Dissertations and Doctoral Studies

Breast cancer is one of the leading causes of morbidity and mortality among women. A diagnosis of cancer is a stressful event that requires an individual to adapt to new stressors. The purpose of this qualitative study was to better understand the perceptions of mana'olana/hope and living with breast cancer among Native Hawaiian women. The conceptual framework of this phenomenological study was positive psychology. Data collection included in-depth interviews with 5 Native Hawaiian women who had been diagnosed with breast cancer. Data coding and analysis resulted in identification of 8 themes.

The themes included: (a) mana'olana /hope is the essence …

The Soldier 360°Orgram: Strengthening Combat-Exposed, Noncommisioned U.S. Army Officers' Interpersonal Sensitivity, Anne Harper

Walden Dissertations and Doctoral Studies

Interpersonal sensitivity is a foundational component of interpersonal relationships. It encompasses an individual's self-concept and self-identity, which are formed as the individual develops. An individual's self-concept develops from the norms and mores of his or her society. Soldiers in the U.S. Army have been trained to form a repurposed self to engage in combat and work in combat-focused jobs. The consequence of this training in many cases has been diminished interpersonal sensitivity that has been detrimental to their interpersonal relationships. The Soldier 360° course is a comprehensive treatment program that takes a holistic approach to providing soldiers with self-empowering tools …