Medicine and Health Sciences Commons^™

Myosin Xva Isoforms Participate In The Mechanotransduction-Dependent Remodeling Of The Actin Cytoskeleton In Auditory Stereocilia, Ana I. López-Porras, Ava M. Kruse, Mark T. Mcclendon, A. Catalina Vélez-Ortega

Neurology Faculty Publications

Auditory hair cells form precise and sensitive staircase-like actin protrusions known as stereocilia. These specialized microvilli detect deflections induced by sound through the activation of mechano-electrical transduction (MET) channels located at their tips. At rest, a small MET channel current results in a constant calcium influx which regulates the morphology of the actin cytoskeleton in the shorter ‘transducing’ stereocilia. However, the molecular mechanisms involved in this novel type of activity-driven plasticity in the stereocilium cytoskeleton are currently unknown. Here, we tested the contribution of myosin XVA (MYO15A) isoforms, given their known roles in the regulation of stereocilia dimensions during hair …

Unilateral Tongue Atrophy In Smad3: A Case Report, Gloria Galloway

Nursing & Health Sciences Research Journal

Background: Mothers Against Decapentaplegic Homolog 3 (SMAD3) is a disorder of the protein encoded at locus 15q22.33 and involved in the transcription of growth factor-beta (TGF) signalling. In this disorder, SMAD3 encoding is impaired, resulting in a connective tissue disorder with multisystem involvement (Bertoli-Avella et al., 2015; Dulac et al., 2019). This case is the first to describe unilateral tongue atrophy as an initial presentation of SMAD3, thereby providing an important contribution to the literature. Clinical History and Exam: A 43-year-old patient described a 1–2-week history in which he noted that half of his tongue had wasted away, and he …

Resting-State Brain Activity And Its Relationship To Mental Health In Epilepsy Using Fmri, Florian Gobellan Rodriguez

McNair Scholars Research Journal

No abstract provided.

Evaluating The Efficiency Of Lossless Compression Algorithms Across Multiple Formats In Archival Compression, Matthew Gonzales

McNair Scholars Research Journal

Data storage or retention is an essential part of all business operations. Modern companies opt to store user data seven years or more after it is deleted and even longer when it’s still being hosted. Therefore, when storing files for long periods of time compression becomes an essential step in reducing cost and total file storage. Compression is the strategic removement of portions of data while ensuring that enough data is left behind to reconstruct the file during decompression. This experiment seeks to identify potential benefits of compression in groups of files of differing formats in comparison to individual file …

Postpartum Depression In North American Ghanaian Women, Natalie Bawuah

McNair Scholars Research Journal

No abstract provided.

Prioritizing The Parent Perspective: A Mixed Methods Approach To Deconstructing Learning Deficiencies Within Marginalized And Underserved Communities, Zea Wallace

McNair Scholars Research Journal

No abstract provided.

An Alternate Way Of Factoring Mathematical Objects And The Mystery Behind Free Resolutions, Tyler Trujillo

McNair Scholars Research Journal

No abstract provided.

Notes From The Director, The Mcnair Team

McNair Scholars Research Journal

No abstract provided.

Letter From The Vice President For Research And Innovation, The Mcnair Team

McNair Scholars Research Journal

No abstract provided.

Chemogenetic Neuronal Silencing Decouples C-Jun Activation From Cell Death In The Temporal Cortex, Caleb A Wood, Preethi Somasundaram, Jacob M Dundee, Melissa A Rudy, Trent A Watkins, Joanna L Jankowsky

Faculty, Staff and Students Publications

Initial symptoms of neurodegenerative diseases are often defined by the loss of the most vulnerable neural populations specific to each disorder. In the early stages of Alzheimer's disease, vulnerable circuits in the temporal lobe exhibit diminished activity prior to overt degeneration. It remains unclear whether these functional changes contribute to regional vulnerability or are simply a consequence of pathology. We previously found that entorhinal neurons in the temporal cortex undergo cell death following transient suppression of electrical activity, suggesting a causal role for activity disruption in neurodegeneration. Here we demonstrate that electrical arrest of this circuit stimulates the injury-response transcription …

Citation Bias, Diversity, And Ethics, Keisha S Ray, Perry Zurn, Jordan D Dworkin, Dani S Bassett, David B Resnik

Faculty and Staff Publications

How often a researcher is cited usually plays a decisive role in that person's career advancement, because academic institutions often use citation metrics, either explicitly or implicitly, to estimate research impact and productivity. Research has shown, however, that citation patterns and practices are affected by various biases, including the prestige of the authors being cited and their gender, race, and nationality, whether self-attested or perceived. Some commentators have proposed that researchers can address biases related to social identity or position by including a Citation Diversity Statement in a manuscript submitted for publication. A Citation Diversity Statement is a paragraph placed …

Challenging Myths & Addressing Intimate Partner Sexual Violence In Lgbtq+ Relationships, Nora K. Whitten

SPARK Symposium Presentations

Intimate partner violence (IPV), including intimate partner sexual violence (IPSV), is a public health crisis that disproportionately affects members of the LGBTQ+ community. This paper draws upon related, though limited, research to identify the five prevalent myths surrounding IPSV in LGBTQ+ relationships, addressing the following misconceptions: 1) IPSV can only occur in heterosexual relationships, 2) IPSV in LGBTQ+ relationships is not as severe, 3) Women cannot commit acts of sexual violence, 4) The more “masculine” partner is always the perpetrator, and 5) IPSV is a “mutual fight” among partners of the same sex. These myths perpetuate victim-blaming, minimize the severity …

The Attachment Repair Hexagon: A Model For Recovery From Infidelity In Evangelical Marriages, Theresa C. Allen, John C. Thomas

Journal of Faith Integration Counseling (JFIC)

Many studies have examined risk factors for infidelity; however, few have investigated how couples recovered from the attachment injury of infidelity. Thus, a grounded theory pilot study was conducted by the lead author to explore the question, “What helps evangelical marriages recover after sexual infidelity by the husband?” Three evangelical couples who were a minimum of two years post-disclosure of infidelity shared their personal accounts of marital recovery. Six major findings emerged from the analysis of the data collected from their semi-structured interviews: 1) developing healthy communication; 2) obtaining support and accountability; 3) maintaining physical separation from the other woman; …

Reduction Of Overactive Bladder Medications In Spinal Cord Injury With Self-Administered Neuromodulation: A Randomized Trial, Argyrios Stampas, Radha Korupolu, Kyung Hyun Lee, Betsy Salazar, Rose Khavari

Faculty, Staff and Student Publications

Purpose: Our goal was to evaluate if self-administered bladder neuromodulation with transcutaneous tibial nerve stimulation could safely replace overactive bladder medications in people with spinal cord injury.

Materials and methods: We performed a 3-month, randomized, investigator-blinded, tibial nerve stimulation vs sham-control trial in adults with spinal cord injury and neurogenic bladder performing intermittent catheterization and taking overactive bladder medications. The primary outcome was a reduction in bladder medications while maintaining stable bladder symptoms and quality of life based on pre/post Neurogenic Bladder Symptom Score and the Incontinence Quality of Life questionnaire, respectively. Secondary outcomes included changes in pre/post cystometrogram, 2-day …

Exposing The Disaster Disparities And Experiences On College Campuses, Deleanor Kirkpatrick Murray

All-Inclusive List of Electronic Theses and Dissertations

Challenges in higher education continue to arise, providing administrators with insights into how prepared—or unprepared—their institutions may be for future crises. The purpose of the study is to examine how mid-level leadership, staff, and students perceived the disaster response to Hurricane Ida during the 2021–2022 academic year. Using the theoretical frameworks of the Four-Frame Model (Bolman & Deal, 2021), Critical Race Theory (Delgado & Stefancic, 2017), and Institutional Theory (Manning, 2018), this case study employed interviews with 8 participants. Data analysis resulted in the emergence of 7 major themes and 11 sub-themes. The findings from the study suggest that participants …

Winter 2024 Edition, Southwestern Oklahoma State University

The Sig

GREETINGS FROM THE DEAN’S OFFICE
Southwestern Opens Doors to Opportunities Beyond Imagination

Homecoming Saturday on October26th was a wonderful day, and we are grateful to all the alumni, family, and friends who attended. Coming back to the COP to rekindle with classmates and faculty is always a special time, especially after many years. As each 50-year and 40-year graduate was recognized and shared a story or special thought with everyone, I was impressed by the common themes.

Issue 12: Pulmonary &Critical Care Insider, Bharat Bajantri Md, Sarah Ellsworth-Hoffman Mls, Dustin D Linn, Numra Urooj Md

Critical Care & Pulmonary

Pulmonary & Critical Care Insider Issue 12

Compiled by Bharat Bajantri, MD, and librarian Sarah Ellsworth, MLS for the clinicians of the Pulmonary and Critical Care team of Parkview.

The Pulmonary & Critical Care Insider newsletter was created by Dr. Bharat Bajantri, MD and Sarah Ellsworth, MLS in 2023 as a form of current awareness for current practice at our hospital, Parkview Health.

Topics: Original Study Summaries, Viewpoints, and Snapshots

Early COPD & Asthma Diagnosis & Treatment, ENHANCE trial, ANNEXA-I trial, Angiotensin II Use in Vasodilatory Shock, Ammonia in Liver Failure, Pirfenidone and more.

Acupressure For Rescue Treatment For Postoperative Nausea And Vomiting, Kimberly Amerson, Jennifer Smith

Doctoral Projects

This doctoral project investigates acupressure as a non-pharmacological option for PONV management, focusing on the P6 point (Neiguan). The physiological processes involved in regulating nausea are highlighted in the discussion of the mechanisms of action. This research also looks at the valuable uses of acupressure in clinical settings and the education of PACU nurses and anesthesia providers. By utilizing knowledge, including acupressure, PACU nurses and anesthesia providers can improve satisfaction with care, expedite recovery, and boost overall patient well-being. This doctoral project strives to decrease healthcare costs associated with prolonged hospital stays, optimize patient recovery experiences, expand knowledge for PACU …

How An Athlete’S Injuries Affect Their Caregiver, John-Luke Taylor, Susan Macdermott

Fall 2024 OTD Capstone Symposium

The purpose of this proposal was to explore the experiences that caregivers face when their child recovers from a sports injury and needs physical rehab.

Parent Perceptions Of Modified Toy Cars Influence On Play For Children With Disabilities: A Case Study, Taylor Brown, Angela Labrie Blackwell, Erik Pérez, Karen Aranha

Fall 2024 OTD Capstone Symposium

Play is a crucial childhood occupation because it facilitates the growth of various developmental skills. Children with disabilities (CWD) often exhibit intrinsic factors that can prevent them from participating in meaningful childhood occupations, such as play. Mobility play is a specific type of play that refers to any means for the child to explore and move around their environment, which can be accessed through the use of commercially available toys, including motorized toy cars. However, these commercially available toys are not always accessible to this population due to their unique presentation that hinders performance and participation in the desired and …

The Benefit Of Creative Arts-Based Interventions For Children With Autism Spectrum Disorder, Marissa Patrick, Zeida Gutierrez

Fall 2024 OTD Capstone Symposium

Autism Spectrum Disorder (ASD) is a neurodevelopmental condition that significantly affects emotional regulation, social communication, and executive functioning. Addressing emotional regulation in children with ASD is essential for enhancing mental health, quality of life, and functional independence in occupations such as social participation. Despite evidence supporting the use of creative arts-based interventions to improve mental health, limited research exists on their specific application for emotional regulation in this population.

This project aimed to implement and evaluate a creative arts-based intervention program designed to improve emotional regulation skills in children with ASD within occupational therapy (OT) practice. Conducted over five weeks …

Occupation-Based Programming For An Addiction Recovery Program, Mckenna Howard, Susan Macdermott Otd, Otr/L

Fall 2024 OTD Capstone Symposium

Addiction can impact engagement in many different occupations and occupational therapists can assist in returning to engagement in meaningful occupations. This capstone project focused on creating occupation-based programming for an addiction recovery program. This program aims to enhance engagement, skills, and confidence in daily occupations to promote overall well-being during recovery.

The Efficacy Of Occupation-Based Caregiver Education On Primitive Reflex Integration In Children With Asd, Alexis Cinotti, Cynthia Haynes

Fall 2024 OTD Capstone Symposium

This capstone research improved the delivery of care regarding caregiver education in children with autism spectrum disorder and retained primitive reflexes. The purpose of this project was to generate resources for occupational therapy practitioners that provide caregiver education on primitive reflex integration interventions that directly correlate with specific ADL’s their child has difficulty with and how to incorporate these exercises in the home environment. Occupational therapy practitioners lack educational resources for caregivers of children diagnosed with ASD to explain the importance and impact of primitive reflex integration on participation in meaningful ADL’s and promote adherence to home exercise programs, implementing …

Understanding The Perceptions Of Technology In Homes For Aging In Place, Jinelle Abugan, Amy Lyons-Brown Ms, Otd, Otr/L, Molly Wuebker Otd, Otr/L, Actcp

Fall 2024 OTD Capstone Symposium

The purpose of this study is to understand the thoughts and experiences of technology in homes and the use of technology-based home modifications to help individuals with participation and performance in daily activities. The education of perceptions of culture in homes will be supported by faculty, OTs, professional designers, about the need to explore culture in technology for home modifications aging in place.

Exercise As A Therapeutic Intervention And Its Effects On The Quality Of Life Of Those Diagnosed With Amyotrophic Lateral Sclerosis, Theresa Stettner, Helen Carey, Cynthia Haynes

Fall 2024 OTD Capstone Symposium

The standard of care for those with ALS includes range of motion, limb relaxation, trunk balance, and gait training (Braga et al., 2018). This study examines perceived quality of life in ALS clients before and after an in-person exercise program and home exercise program to evaluate the benefits of exercise as exercise does not exacerbate symptoms of ALS (Meng et al., 2020). Daily occupation performance requires functional ability which may be preserved through exercise (Kalron et al., 2021).

Discrepancy Between Hyaluronic Acid Levels And Mri-Based Measurements Of Hepatic Fat And Fibrosis, Daniel Aaron Borman, Rachel Chevalier, Jonathan Wagner, Michele T. Pritchard, Sherwin S. Chan, Nathan S. Artz, Johnston Fite, Yoon Cho, Valentina Shakhnovich, Veronica Williams, Voytek Slowik

Posters

Introduction Metabolic-dysfunction-associated steatotic liver disease (MASLD) is the most common liver disease in children in the United States and, when left untreated, can progress to liver fibrosis. Clinicians currently utilize imaging and biopsy to assess fibrosis in this patient population as there is no validated serum biomarker available for detecting fibrosis. Previous research suggests that serum hyaluronic acid levels are predictive of hepatic fibrosis in children with MASLD. Methods Retrospective data were obtained from the Children’s Mercy Hospital Liver Lab study. Pediatric subjects with both hyaluronic acid (HA) samples and MRI evaluation within a month were identified and included for …

Process Evaluation Of A Randomised Controlled Trial Intervention Designed To Improve Rehabilitation Services For Aboriginal Australians After Brain Injury: The Healing Right Way Trial, Judith M. Katzenellenbogen, Jane White, Melanie Robinson, Sandra C. Thompson, Amy Epstein, Mandy Stanley, Jane Klobas, Emma Haynes, Elizabeth A. Armstrong, Juli Coffin, Rachel Skoss

Research outputs 2022 to 2026

Background: Healing Right Way (HRW) aimed to improve health outcomes for Aboriginal Australians with stroke or traumatic brain injury by facilitating system-level access to culturally secure rehabilitation services. Using a stepped-wedge randomised controlled trial (RCT) design (ACTRN12618000139279, 30/01/2018), a two-pronged intervention was introduced in four rural and four urban hospitals, comprising 1.Cultural security training (CST) for staff and 2.Training/employment of Aboriginal Brain Injury Coordinators (ABIC) to support Aboriginal patients for 6-months post-injury. Three-quarters of recruited patients lived rurally. The main outcome measure was quality-of-life, with secondary outcomes including functional measures, minimum processes of care (MPC); number rehabilitation occasions of service …

Differences In Igg Afucosylation Between Groups With And Without Carotid Atherosclerosis, Cuihong Tian, Xingang Li, Hongxia Zhang, Jieyi He, Yan Zhou, Manshu Song, Peixuan Yang, Xuerui Tan

Research outputs 2022 to 2026

Background: A previous study demonstrated that N-glycosylation profiles of IgG are associated with subclinical atherosclerosis in a British population. However, the generalisability of this finding to other ethnic groups remains to be investigated, and it has yet to account for additional traditional atherosclerotic risk factors. The present study, thus, aims to explore IgG N-glycosylation profiles in Han Chinese with atherosclerosis, and their potential role in atherosclerosis, while controlling for traditional atherosclerotic risk factors. Methods: Data of this case-control study were obtained from an established umbrella Health Examination Cohort Study (registration number: ChiCTR2100048740). The investigation was conducted at the Health Care …

The Effects Of Short-Term, Progressive Exercise Training On Disease Activity In Smouldering Multiple Myeloma And Monoclonal Gammopathy Of Undetermined Significance: A Single-Arm Pilot Study, A. Emery, S. Moore, J. Crowe, J. Murray, O. Peacock, D. Thompson, F. Betts, S. Rapps, L. Ross, D. Rothschild-Rodriguez, A. A. Echarri, R. Davies, R. Lewis, D. X. Augustine, A. Whiteway, Z. Afzal, J. L. J. Heaney, M. T. Drayson, J. E. Turner, John P. Campbell

Research outputs 2022 to 2026

Background: High levels of physical activity are associated with reduced risk of the blood cancer multiple myeloma (MM). MM is preceded by the asymptomatic stages of monoclonal gammopathy of undetermined significance (MGUS) and smouldering multiple myeloma (SMM) which are clinically managed by watchful waiting. A case study (N = 1) of a former elite athlete aged 44 years previously indicated that a multi-modal exercise programme reversed SMM disease activity. To build from this prior case study, the present pilot study firstly examined if short-term exercise training was feasible and safe for a group of MGUS and SMM patients, and secondly …

Co-Design Of A Personalised Digital Intervention To Improve Vegetable Intake In Adults Living In Australian Rural Communities, Katherine M. Livingstone, Jonathan C. Rawstorn, Laura Alston, Stephanie R. Partridge, Amber Bastian, Kate Dullaghan, Sarah A. Mcnaughton, Gilly A. Hendrie, Lauren C. Blekkenhorst, Ralph Maddison, Yuxin Zhang, Scott Barnett, John C. Mathers, Stephanie L. Godrich

Research outputs 2022 to 2026

Background: Diets low in vegetables are a main contributor to the health burden experienced by Australians living in rural communities. Given the ubiquity of smartphones and access to the Internet, digital interventions may offer an accessible delivery model for a dietary intervention in rural communities. However, no digital interventions to address low vegetable intake have been co-designed with adults living in rural areas. This paper describes the co-design of a digital intervention to improve vegetable intake with rural community members and research partners. Methods: Active participants in the co-design process were adults ≥ 18 years living in three rural Australian …