Medicine and Health Sciences Commons^™

Electrochemical Sensors For In Situ Monitoring Of Reactive Species During Cold Atmospheric Plasma-Based Therapies, Jonathan Thomas, Suneel Kumar, Gagana Karkada, Julia Sutter, Kristina Pattison, Jason Rainone, Dhruv Patel, Shashank Madhavan, Fred Krebs, Francois Berthiaume, Vandana Miller, Katharina Stapelmann

Kimmel Cancer Center Faculty Papers

Cold atmospheric pressure plasma (CAP) is emerging as a clinically relevant therapy for dermatological conditions such as actinic keratosis, warts, and chronic wounds. However, these therapies lack strategies to monitor CAP delivery in situ and to ensure delivery of an effective CAP dose without unwanted toxicity. CAP acts as a therapeutic agent in these biomedical applications primarily (but not solely) through reactive oxygen and nitrogen species (RONS) generated at transiently high local concentrations. Here we demonstrate the use of bio-electrochemical sensors capable of real-time measurements of key CAP RONS: hydrogen peroxide and oxidation-reduction-potential (ORP). In in vitro scratch assays and …

Proceedings Of The 4th Research In High Performance Sports Colloquium (Hpsc 2025), Sultan Qaboos University

Sultan Qaboos University Medical Journal

No abstract provided.

Identification Of Predictive Pretreatment Biomarkers For Neoadjuvant Chemotherapy Response In Latino Invasive Breast Cancer Patients, Hedda Michelle Guevara-Nieto, Rafael Parra-Medina, Carlos A. Orozco, Sandra Diaz-Casas, Jone Garai, Jovanny Zabaleta, Liliana López-Kleine, Alba L. Combita

School of Medicine Faculty Publications

Background: Breast cancer (BC) exhibits significant heterogeneity in incidence and mortality worldwide. Neoadjuvant chemotherapy (NAC) is the standard treatment for locally advanced BC; however, its efficacy varies by subtype. This study examined the gene expression profiles associated with NAC response in Colombian women with invasive BC. Methods: RNA sequencing of pre-treatment tissues from 58 patients (29 responders and 29 non-responders) identified differentially expressed genes (DEGs) for each molecular subtype, and prognostic performance was evaluated using risk scores. Results: Functional enrichment analysis highlighted the immune system pathways in non-responders. Changes in cytokine target activity and immune cell populations were analyzed to …

The Need To Incorporate Polysubstance Use In Neuropsychopharmacology Research: Biological Lessons And New Opportunities, Max E. Joffe, Susan M. Ferguson, Nick W. Gilpin, Melissa A. Herman, Lori A. Knackstedt, Patrick A. Randall, Abigail G. Schindler, Mary M. Torregrossa, Jennifer A. Rinker

School of Medicine Faculty Publications

Critical evaluation and refinement of animal models is essential for neuroscientists to understand complex physiological and pathological processes related to psychiatric diseases. In general, preclinical studies modeling drug dependence and problematic substance use have been limited to the administration of a single substance; however, there is a growing appreciation that this approach has failed to capture the complexities of humans and has stifled translational efforts. Polysubstance use represents the overwhelmingly common patterns of alcohol and drug use in humans. For example, epidemiological studies generally determine that between 70–95 % of individuals with alcohol use disorder use tobacco daily, and upwards …

Are E-Cigarettes A Safer Alternative? Revisiting The Cardiovascular Cost Of Nicotine Delivery, Jason D. Gardner

School of Graduate Studies Faculty Publications

No abstract provided.

Conservative Vs Invasive Interventions For Temporomandibular Disorders–An Executive Summary Of The Clinical Practice Guideline, Gary D. Klasser, Charles S. Greene

School of Dentistry Faculty Publications

This guideline is based on the International Association for Dental, Oral, and Craniofacial Research (IADR) list of keypoints for the diagnosis and management of TMDs. Clinical Question: Are conservative reversible therapies more effective for TMDs as compared to invasive and irreversible interventions?

Tgfbr2 Coordinates The Endometrial Response To Estrogen, Regulating Endometrial Hyperplasia And Fertility, Sydney E Parks, Suni Tang, Anna Catherine Unser, Ananya L Bhonsley, Eunbi M Chung, Peixin Jiang, Audrey Savolainen, Vanessa J Joseph, Dominique I Cope, Ramya P Masand, Renata Prunskaite-Hyyryläinen, Diana Monsivais

Faculty, Staff and Students Publications

Proper endometrial function is critical for establishing and maintaining healthy pregnancies, as well as preventing the pathogenesis of conditions such as endometrial hyperplasia and endometrial cancer. The TGFβ signaling pathway regulates key aspects of endometrial biology, although the direct effects of many individual receptors remain unstudied. In this study, we characterize the role of TGFβR2 within the endometrium using a progesterone receptor-cre conditional knock-out mouse model (Tgfbr2flox/flox;Pgrcre/+; “Tgfbr2 cKO”). We found that conditional deletion of TGFβR2 resulted in female infertility, endometrial hyperplasia, altered estrogen and progesterone response, and, only in bred females, reproductive tract …

International Consensus Guidelines For The Conduct And Reporting Of Car T-Cell Clinical Trials In Aml, Swati Naik, Richard Aplenc, Susanne H C Baumeister, Marco Becilli, Anand S Bhagwat, Challice L Bonifant, Lihua E Budde, Christopher D Chien, Kevin J Curran, Anthony F Daniyan, Alexandra Dreyzin, Rebecca A Gardner, Sara Ghorashian, Stephen Gottschalk, Laquisa C Hill, M Eric Kohler, Adam Lamble, Franco Locatelli, Maksim Mamonkin, Bilal Omer, Jae H Park, Concetta Quintarelli, Benedetta Rambaldi, Rebecca M Richards, David A Sallman, Tim Sauer, Nirali N Shah, Marion Subklewe, Corinne Summers, Sarah K Tasian, Naomi Taylor, Sarah Tettamanti, Michael R Verneris, M Paulina Velasquez, Saar I Gill

Faculty, Staff and Students Publications

Early clinical experience with the use of chimeric antigen receptor (CAR) T-cell therapies for patients with acute myeloid leukemia (AML) has been beset by high rates of toxicities and low rates of response. We convened an international workshop with the goal of bringing investigators in the field of AML-directed CAR T-cell therapy together to facilitate discussion of challenges and to brainstorm potential solutions. Based on discussions at the workshop, it was evident that (1) treating and targeting AML with CAR T cells is associated with unique clinical challenges, and (2) variability in clinical trial design, definitions of toxicities, correlative data …

To Jump Or Not To Jump: Comparing Effects Of Phenotypic Plasticity On The Visual Responses And Escape Behavior Of Locusts And Grasshoppers, Soumi Mitra, Saina Namazifard, David Mario Bellini, Alexis Leigh Sarne, Bidisha Halder, Margaret Ruth Eisenbrandt, Aliya Macknojia, Jiayi Luo, Samme Xie, Hojun Song, Chenghang Zong, Fabrizio Gabbiani, Richard Burkett Dewell

Faculty, Staff and Students Publications

Locusts exhibit remarkable phenotypic plasticity changing their appearance and behavior from solitary to gregarious when population density increases. These changes include morphological differences in the size and shape of brain regions, but little is known about plasticity within individual neurons and alterations in behavior not directly related to aggregation or swarming. We investigated looming escape behavior and the properties of a well-studied collision-detection neuron in gregarious and solitarious animals of three closely related species, the desert locust (Schistocerca gregaria), the Central American locust (S. piceifrons) and the American bird grasshopper (S. americana). For this neuron, the lobula giant movement detector …

The Effectiveness Of Telemedicine As A Pivotal Tool In Providing Accessible Medical Care, Peyton Wilt

Honors Theses

Telemedicine has emerged as one of the most transformative innovations in modern healthcare, offering new opportunities to bridge long-standing gaps in access, quality, and continuity of care. Rural and underserved communities in the United States face persistent barriers to healthcare, including provider shortages, geographic isolation, limited access to specialty services, transportation challenges, and socioeconomic disparities. These structural barriers often delay diagnosis, disrupt chronic disease management, and worsen overall health outcomes. Telemedicine provides a mechanism to address many of these obstacles by enabling remote consultations, real-time monitoring, follow-up appointments, and access to specialty providers through digital platforms.

This thesis examines the …

Implementing The Nyu Electronic Patient Visit Assessment (Epva), Janet H Van Cleave, Abraham A Brody, Dena Schulman-Green, Kenneth S Hu, Zujun Li, Stephen B Johnson, Vincent J Major, Christopher E Lominska, Jessica R Bauman, Alexander N Hanania, Ghia V Tatlonghari, Marcely Tsikis, Brian L Egleston

Faculty, Staff and Students Publications

Background: Aggressive treatment with multimodal therapies such as surgery, chemotherapy, and radiation therapy has improved survival in head and neck cancer (HNC) but at a human cost of a substantial symptom burden and impact on quality of life. We developed the NYU Electronic Patient Visit Assessment (ePVA)© for HNC as a digital patient-reported symptom monitoring system that enables early symptom detection and real-time interventions at the point of care. With this study protocol, we aim to test the effectiveness of the ePVA in improving HNC outcomes in real-world settings and to identify implementation strategies optimizing its effectiveness.

Methods: We will …

In-Silico Test Of Myricetin, Phyllanthin, Luteolin Compounds Against Sars-Cov-2 Proteins, Vidia Noviyanti, Nuha Haifa Arifin, Hayu Ikfini, Rifki Febriansah

Pharmaceutical Sciences and Research

Coronavirus disease 2019 (COVID-19), which emerged in late 2019 and was first detected in Indonesia in March 2020, has significantly reshaped the country’s public health landscape. Aside from the viral outbreak itself, a decline in immunity among the population due to excessive concern about the pandemic has also become a significant issue. This study aimed to evaluate the potential of myricetin, phyllanthin, and luteolin compounds as inhibitors of the SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) virus by targeting the main protease and spike glycoprotein receptor-binding domain proteins through in silico molecular docking. Remdesivir and favipiravir were used as comparison …

Rare Epigenetic Alterations Are Conserved Across Hematopoietic Differentiation Stages After Mycobacterial Infection, Brandon T Tran, Pamela N Luna, Ruoqiong Cao, Duy T Le, Apoorva Thatavarty, Laure Maneix, Bailee N Kain, Scott Koh, Andre Catic, Katherine Y King

Faculty, Staff and Students Publications

Infection leads to durable cell-autonomous changes in hematopoietic stem and progenitor cells (HSPCs), resulting in production of innate immune cells with heightened immunity. The mechanisms underlying this phenomenon, termed central trained immunity, remain poorly understood. We hypothesized that infection induces histone modifications leading to changes in chromatin accessibility that are conserved during differentiation from HSPCs to myeloid progenitors and monocytes. We conducted genome-wide surveillance of histone marks H3K27ac and H3K4me3 and chromatin accessibility in hematopoietic stem cells, multipotent progenitor 3, granulocyte-monocyte progenitors, monocytes and macrophages of naïve and Mycobacterium avium infected mice. Interferon signaling pathways and related transcription factor binding …

Circulating Tumor Dna Refines Risk Stratification Of Neoadjuvant Therapy-Resistant Breast Tumors, Mark Jesus M Magbanua, Nayelis A Manon, Denise M Wolf, Samuel Rivero-Hinojosa, Ziad Ahmed, Rosalyn W Sayaman, Antony Tin, Derrick Renner, Ekaterina Kalashnikova, Lamorna Brown-Swigart, Gillian L Hirst, Christina Yau, Wen Li, Claudine Isaacs, Rebecca A Shatsky, Amy S Clark, Alexandra Zimmer, Amy L Delson, Angel Rodriguez, Minetta C Liu, Paula R Pohlmann, Laura J Esserman, Hope S Rugo, Angela Demichele, Laura Van 'T Veer

Faculty, Staff and Student Publications

Early-stage breast cancers resistant to neoadjuvant therapy (NAT), characterized by high residual cancer burden (RCB) after treatment, have an increased risk of metastatic recurrence. Here, we show that circulating tumor DNA (ctDNA) detected using a tumor-informed test (1) can improve risk stratification of patients with NAT-resistant tumors (RCB-II/RCB-III) and (2) predict response to NAT. Stratification using ctDNA status at pretreatment or post-NAT and ctDNA dynamics identified NAT-resistant tumors with a significantly decreased risk of metastatic recurrence. ctDNA clearance as early as week 3 across receptor subtypes predicted favorable responses to NAT, including immunotherapies. Interestingly, less than a fifth of patients …

Single Cell Spatial Profiling Of The Matrisome Identifies Region-Specific Adhesion And Signaling Networks In Glioblastoma, Arpan De, Santiago A Forero, Ali Pirani, John E Morales, Marisol De La Fuente-Granada, Sumod Sebastian, Jason T Huse, Leomar Y Ballester, Jeffrey S Weinberg, Frederick F Lang, Kadir C Akdemir, Joseph H Mccarty

Faculty, Staff and Student Publications

The human brain contains a milieu of extracellular matrix (ECM) components that promote normal development and physiology. ECM signaling pathways are often dysregulated in brain pathologies including the malignant cancer glioblastoma (GBM). Here, we used single-cell spatial transcriptomic platforms to map the expression of nearly 400 ECM genes in matching non-cancerous brain and GBM samples. At least four different GBM cell populations have been identified that show unique ECM expression profiles and spatial enrichment in distinct intratumor regions. Spatial mapping demonstrates largely non-overlapping expression signatures of ECM components in GBM stromal cell types, particularly in vascular endothelial cells and microglia/macrophages. …

Nktr-255 Enhances Complete Response Following Cd19 Car T-Cell Therapy In Patients With Relapsed/Refractory Large B-Cell Lymphoma, Sairah Ahmed, John Dipersio, Et Al.

2020-Current year OA Pubs

No abstract provided.

Deep Profiling Of Human T Cells Defines Compartmentalized Clones And Phenotypic Trajectories Across Blood And Tonsils, Suhas Sureshchandra, Elizabeth Levendosky, Allyssa Daugherty, Samuel J H Murphy, Chandrani Thakur, Naresha Saligrama, Et Al.

2020-Current year OA Pubs

98% of T cells reside in tissues, yet nearly all human T cell analyses are performed on peripheral blood. We performed single-cell sequencing of 5.7 million T cells from autologous blood and tonsils of ten donors. We identified distinct patterns of clonal expansion associated with tonsil-restricted phenotypes. Clonal sharing between blood and tonsils was lower than previous estimates and increased with age. Identical T cell receptor (TCR) sequences exhibited limited concordance in their phenotypes across compartments. Furthermore, location dictated the frequencies, clonal dominance, and phenotypes of antigen-specific T cells. Using immune organoids, we showed that antigen exposure drives functionally distinct …

Glycoside Hydrolase-Mediated Glucomannan Catabolism In Segatella Copri, A Target Of Microbiota-Directed Foods For Malnourished Children, Cyrus Zhou, Matthew C Hibberd, Evan M Lee, Suzanne Henrissat, Marie A Crane, Jiye Cheng, Michael J Barratt, Jeffrey I Gordon, Et Al.

2020-Current year OA Pubs

Evidence is emerging that perturbed postnatal gut microbiota development is causally related to childhood undernutrition. Clinical trials in undernourished Bangladeshi children found that a polysaccharide-rich, microbiota-directed complementary food (MDCF-2) designed to repair this perturbation produced superior ponderal and linear growth compared to a standard ready-to-use supplementary food. Subsequent analyses disclosed several candidate bioactive polysaccharides in the MDCF and their bacterial targets, notably strains of

Camidanlumab Tesirine For Relapsed Or Refractory Classic Hodgkin Lymphoma: A Phase 2 Study, Alex F Herrera, Nancy L Bartlett, Et Al.

2020-Current year OA Pubs

Outcomes in classic Hodgkin lymphoma (cHL) have steadily improved; however, additional therapies are needed for patients who relapse or do not respond to novel agents. Here, we report the efficacy and safety of camidanlumab tesirine (Cami), an anti-CD25 antibody-drug conjugate, in patients with relapsed/refractory cHL after brentuximab vedotin/programmed cell death protein 1 inhibitor therapies from the phase 2 ADCT-301-201 study. Eligible patients were adults with cHL who had received ≥3 previous lines of systemic therapy (or ≥2 if ineligible for hematopoietic stem cell transplant). Patients received 45 μg/kg Cami (IV, once every 3 weeks) in cycles 1 to 2, followed …

Association Of Pet4 Response With Outcomes Of Bv-Chp Vs Chop In The Echelon-2 Trial In Cd30+ Peripheral T-Cell Lymphoma, Swaminathan Iyer, Neha Mehta-Shah, Nancy L Bartlett, Et Al.

2020-Current year OA Pubs

In the phase 3 ECHELON-2 trial, brentuximab vedotin, cyclophosphamide, doxorubicin, and prednisone (BV-CHP) significantly improved progression-free survival (PFS) and overall survival (OS) compared with cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) in patients with CD30+ peripheral T-cell lymphoma, benefits that were maintained at 5 years. Interim positron emission tomography (PET) scan can be used to assess prognosis and risk-stratify patients. The prognostic value of interim PET was assessed in this post hoc exploratory analysis from ECHELON-2, evaluating interim 18F-fluorodeoxyglucose PET scans after cycle 4 (PET4) and end-of-treatment-based response, and correlated with PFS per investigator and OS. PET4 response was determined by …

Biological Parenthood Rates Among Men With Sickle Cell Disease, Anyssa N Young, Sarah R Hayford, Sapuni S Chandrasena, Sara Conroy, Tanvi P Karkare, Barbara L Kroner, Allison King, Robert M Cronin, Luca Badolato, Leena Nahata, Susan E Creary

2020-Current year OA Pubs

No abstract provided.

The Effects Of Kanpu Masatsu On Sleep Quality And Fatigue Among Older Adults, Aidan Miranda, Yessica Luna Beltran

International Journal of Exercise Science: Conference Proceedings

Sleep quality is crucial for overall health, particularly among older adults. Kanpu Masatsu (KM), a traditional Japanese self-massage technique using dry towels, has been associated with health benefits for this population. PURPOSE: This study explores the effects of performing Kanpu Masatsu before bedtime on sleep quality and fatigue levels. METHODS: Twelve healthy older adults (3 men and 9 women; age 60.67 ± 1.69 years) were recruited to monitor their sleep over 14 days using a Fitbit Sense 2. During the second week, participants performed a whole-body Kanpu Masatsu within 10 minutes before sleep. Sleep quality was assessed via Fitbit’s sleep …

Accuracy Of The Garmin Instinct For Heart Rate Monitoring During Forearm Exercise With And Without Blood Flow Restriction, Danilo Dullas, Clifford Sanders, Yahtziri Martinez, Tevin Perez, Alana Tucker, Amelia Wolfe, Juni Timmins, Catalina M. Kerwin, Kynlee Sperry, Cannon Jones, Heather Zent, Sam Brinkerhoff, Setareh Zarei, Jeff Guzman, Rodolfo I. Mejia, Nathaniel Bodell, James W. Navalta, Merrill Funk, Jeffrey Cowley, Marcus M. Lawrence

International Journal of Exercise Science: Conference Proceedings

Wearable devices are widely used to monitor heart rate (HR) during exercise, but their accuracy under blood flow restriction (BFR) remains uncertain. Because BFR is increasingly applied in rehabilitation and strength training, accurate HR monitoring is essential for both safety and prescription. The PURPOSE of this study was to evaluate the reliability of the Garmin Instinct smartwatch for measuring HR during forearm exercise with and without BFR, compared to a chest-strap criterion device. METHODS: Twenty-three healthy adults (9 females, 14 males; mean age = 24.74 ± 8.19 years) participated in a repeated-measures design. After providing consent and being fitted with …

Validity Of The Polar Verity Sense In Measuring Heart Rate During A Hand Grip Assessment With Blood Flow Restriction, Jeff Guzman, James W. Navalta, Marcus M. Lawrence, Nathaniel Bodell, Jeffrey Cowley, Setareh Zarei, Rodolfo I. Mejia, Catalina M. Kerwin, Kynlee Sperry, Juni Timmins, Cannon Jones, Sam Brinkerhoff, Danilo Dullas, Clifford Sanders, Yahtziri Martinez, Tevin Perez, Alana Tucker, Amelia Wolfe, Merrill Funk

International Journal of Exercise Science: Conference Proceedings

Blood flow restriction (BFR) training has acquired significant attention in rehabilitation and performance sciences. Polar is a popular heart rate (HR) device manufacturer, Polar Electro OY. PURPOSE: The purpose of this study was to investigate the validity of HR from the Polar Verity Sense biceps band vs the Polar H10 chest strap during a hand grip assessment with blood flow restriction. METHODS: Twenty-three adults (9 females, 14 males, Identified otherwise n = 0; age=24.74±8.19 years, height = 172 cm (SD =9) Mass = 79kg (SD= 18.5) were recruited via convenience sampling. Participants were asked to do a warm-up including 5-min …

Ach Health Hotline: Summary 2025

CompassPoint

Each summer, camp health and leadership teams encounter a wide range of challenges that reflect the complexities of creating safe, supportive environments for young people. Camps experience moments of uncertainty—health concerns, behavioral issues, environmental emergencies, and emotional struggles. The Alliance for Camp Health (ACH) Health Hotline is a vital resource supporting camps by offering real-time guidance, reassurance, and problem-solving.

This summer’s hotline calls tell the stories of how health staff navigated physical health challenges, from directors seeking clarity regarding care protocols to communities facing natural disasters, heat waves, and unexpected illnesses. Each caller received support, encouragement, and guidance to improve …

Seizures In Camp Settings, Sandra Shapiro, Taylor Gilman, Tamar Sternfield, Jolie Skivington

CompassPoint

Managing seizures in the summer camp environment presents unique challenges, requiring not only medical attention but also empathy and understanding from both peers and caregivers. Approximately 0.5–5% of children and adolescents will experience at least one afebrile seizure by adolescence and there is a 3.6% risk of experiencing at least one seizure in an 80-year-lifespan (Murphy et al., 1995 as cited in Wilfong, 2025). Recognizing how to support a child with seizures during the camp season is essential to promoting their safety and well-being while also ensuring they have a positive and inclusive camp experience.

Understanding Lyme Iaci: Implications For Camp Nurses, Mary Tobin

CompassPoint

Lyme Infection-Associated Chronic Illness (Lyme IACI) is a term adopted by the U.S. National Academies of Sciences, Engineering, and Medicine (NASEM) to describe persistent, often debilitating symptoms that follow Lyme disease infection. Affecting an estimated 10–20% of individuals treated for Lyme disease, Lyme IACI includes fatigue, musculoskeletal pain, cognitive dysfunction, and sleep disturbances that can last months or even years despite standard antibiotic therapy (NASEM, 2025). Unlike acute Lyme disease, Lyme IACI is not well understood and lacks validated diagnostic tools or biomarkers, making it a challenge to diagnose or treat for clinicians and caregivers—especially those working with children in …

Health Center Staff I: Where We Are Now And Considerations For The Future, Tracey Gaslin, Beth Schultz, Ann Laske, Alexandra Skrocki

CompassPoint

Having appropriate and qualified healthcare staff aligns with safe, well-coordinated services. When a camp identifies what health services they wish to provide (e.g., screening, medication management, delegation, documentation, communicable disease planning), they are better able to determine who has the appropriate education and credentials to provide those services. Additional variables to consider when making decisions about camp healthcare staff include the camp’s distance from higher-level care, risks associated with camp activities, and populations being served.

Nursing At Summer Camp: Piloting A Novel Clinical Rotation Experience For Undergraduates In Pediatrics, Vanessa Lugo

CompassPoint

Nursing schools have traditionally relied on inpatient settings as the primary venue for clinical placement for undergraduate courses. However, the availability of clinical placement sites has diminished in recent years for reasons that include faculty retirements, problems with administrative support and coordination in large hospital systems, and intensified competition among health-profession schools for a limited pool of rotation sites (Chesney et al., 2021; American Association of Colleges of Nursing, 2022). Clinical placement sites became especially sparse during the COVID-19 pandemic, when many facilities prohibited on-site student instruction (Kaveh et al., 2022; Ridgway et al., 2022). Nursing schools in rural areas …

Clinical Corner: Pearls From Local Dentists

West Michigan District Dental Society Bulletin

"Clinical Corner" is a section of the WMDDS Bulletin where local dentists share clinical pearls for fellow practitioners. Topics include at home spot treating localized sensitivity, solving the “mess” of water flossers, and focused evaluation of third molars.