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Full-Text Articles in Medicine and Health Sciences

Use Of The Delphi Technique In Instrument Development To Assess Debriefing Facilitation, E. Adel Herge, Otd, Otr/L, Susan Wainwright, Pt, Phd, Jennifer Saylor, Phd, Rn, Acns-Bc Jun 2015

Use Of The Delphi Technique In Instrument Development To Assess Debriefing Facilitation, E. Adel Herge, Otd, Otr/L, Susan Wainwright, Pt, Phd, Jennifer Saylor, Phd, Rn, Acns-Bc

Thomas Jefferson University Faculty Days

Debriefing is an essential part of the simulation experience because this is where most of the learning occurs (Arafah, Hansen & Nichols, 2010). To date, there are no validated instruments to measure the ability of a facilitator to effectively debrief learners after a patient simulation.

This poster describes phase one of a pilot study to develop and evaluate an instrument that assesses the effectiveness of a debriefing facilitator. The instrument is based on the current scientific literature and was tested to establish reliability and validity. In phase one, the Delphi Technique was selected as it has been shown to be …


College Within The College: Population Health, James Plumb, Md, Mph, Rickie Brawer, Phd, Mph, Mches, Abbie Santana, Msph, Robert Simmons, Drph, Mph, Mches, Cph, Nancy Chernett, Ma, Mph Jun 2015

College Within The College: Population Health, James Plumb, Md, Mph, Rickie Brawer, Phd, Mph, Mches, Abbie Santana, Msph, Robert Simmons, Drph, Mph, Mches, Cph, Nancy Chernett, Ma, Mph

Thomas Jefferson University Faculty Days

Rationale:

The current approach to educating health professionals has not kept pace with the needs of our growingly diverse population.

-Health Professional Education for the 21st Century-The Lancet

-Institute of Medicine

-APTR/CDC/AAMC-Patients and Populations. Public Health in Medical Education

JMC Leadership and Curriculum Committee-one year planning process-2009-2010


10,000th Asset Archived In The Jdc, Daniel G. Kipnis, Msi Jun 2015

10,000th Asset Archived In The Jdc, Daniel G. Kipnis, Msi

Jefferson Digital Commons News

Rejoice! Hooray!! The Jefferson Digital Commons has archived its 10,000th item. The lucky 10,000th item was published by David Nash, MD, MBA and Eugene Mochan, PhD, DO from the Jefferson School of Population Health, Thomas Jefferson University.


2015 Commencement For Jefferson School Of Health Professions, Jefferson School Of Pharmacy, And Jefferson School Of Nursing May 2015

2015 Commencement For Jefferson School Of Health Professions, Jefferson School Of Pharmacy, And Jefferson School Of Nursing

Jefferson College of Nursing Commencements

No abstract provided.


Use Of Medicare Claims As A Source For Research Prevalence And Utilization Of Medical Care Services In Persons With Autism Spectrum Disorder Over And Under Age 65, Henry J. Carretta, Phd, Katelyn Graves, Ms, Teal W. Benevides, Phd, Ms, Otr/L May 2015

Use Of Medicare Claims As A Source For Research Prevalence And Utilization Of Medical Care Services In Persons With Autism Spectrum Disorder Over And Under Age 65, Henry J. Carretta, Phd, Katelyn Graves, Ms, Teal W. Benevides, Phd, Ms, Otr/L

Department of Occupational Therapy Posters and Presentations

Objective:

1. To evaluate the feasibility of using Medicare claims by determining the number of identifiable persons with autism spectrum disorder (ASD) in a three year limited data set (2008-2010)

2. To describe the structure, types, and limitations of Medicare claims files for ASD research


Assorted Grand Rounds From April And May 2015, Daniel G. Kipnis, Msi May 2015

Assorted Grand Rounds From April And May 2015, Daniel G. Kipnis, Msi

Jefferson Digital Commons News

The Jefferson Digital Commons has a varied collection of grand rounds archived from numerous departments including:


Identification And Linkage To Care Of Hcv-Infected Persons In Five Health Centers-Philadelphia, Pennsylvania, 2012-2014, Catelyn Coyle, Mph May 2015

Identification And Linkage To Care Of Hcv-Infected Persons In Five Health Centers-Philadelphia, Pennsylvania, 2012-2014, Catelyn Coyle, Mph

JCPH Alumni

Approximately three million persons in the United States are infected with hepatitis C virus (HCV), a blood-borne pathogen that is an increasing cause of liver disease and mortality in the United States (1,2). Treatments for HCV are curative, of short duration, and have few associated side effects (3), increasing the importance of identifying HCV-infected persons. Many persons with HCV infection were infected decades ago, before implementation of prevention measures and most are unaware of their infection, regardless of when it occurred (4). Most newly diagnosed cases are associated with injection drug use (5). Persons born during 1945–1965 have a fivefold …


2015 Create Day Presentations In The Jdc, Daniel G. Kipnis, Msi May 2015

2015 Create Day Presentations In The Jdc, Daniel G. Kipnis, Msi

Jefferson Digital Commons News

Collaborative Research and Evidence Among Therapists and Educators (CREATE) Day is a clinical education program presented by occupational therapy graduate students in partial fulfillment of the Master of Science degree in Occupational Therapy at Thomas Jefferson University. Students conduct a systematic review of the literature on key topic areas that reflect current occupational therapy practice trends. The presentations include an introduction of the topic literature.

The latest round of 2015 Collaborative Research and Evidence Among Therapists and Educators (CREATE) Day presentations have been loaded into the Jefferson Digital Commons


Transplantation Of Kidneys From Donors With Acute Renal Failure Five-Year Results From Double Center Experience, Ahmad Safra, Md, Ashesh P. Shah, Md, Cataldo Doria, Md, Phd, Warren R Maley, Md, Adam M. Frank, Md, Chad Gorn, Laurel Lerner, Rn, Marie Manley, Carlo B Ramirez, Md May 2015

Transplantation Of Kidneys From Donors With Acute Renal Failure Five-Year Results From Double Center Experience, Ahmad Safra, Md, Ashesh P. Shah, Md, Cataldo Doria, Md, Phd, Warren R Maley, Md, Adam M. Frank, Md, Chad Gorn, Laurel Lerner, Rn, Marie Manley, Carlo B Ramirez, Md

Department of Surgery Faculty Papers

Background:

Transplantation of kidneys from deceased donors with acute renal failure (ARF) has been described and represents an underutilized source of renal grafts. We reviewed retrospectively our double center experience with transplantation of ARF donor kidneys.

Methods:

Between January 2009 and June 2014, we performed a total of 397 kidney transplants at the two hospitals. Of which, 65 came from donors with ARF. The outcome was compared with 62 expanded criteria donor kidneys and 270 standard criteria donor kidneys. ARF was defined as donor terminal creatinine higher than 2. All kidneys from ARF donors had acceptable biopsies and were pumped. …


Declaring A Patient Brain Dead On Extracorporeal Membrane Oxygenation (Ecmo): Are There Guidelines Or Misconceptions, Kristin J. Kreitler, Nicholas C. Cavarocchi, Hitoshi Hirose, Sharon West, Richard Hasz, Michelle Ghobrial, Rodney D. Bell May 2015

Declaring A Patient Brain Dead On Extracorporeal Membrane Oxygenation (Ecmo): Are There Guidelines Or Misconceptions, Kristin J. Kreitler, Nicholas C. Cavarocchi, Hitoshi Hirose, Sharon West, Richard Hasz, Michelle Ghobrial, Rodney D. Bell

Department of Surgery Faculty Papers

Objectives:

  • To review the clinical practice variations and trends with declaring patients brain dead on ECMO
  • To highlight the need for the development of consensus guidelines to assist clinicians in the accurate diagnosis of brain death in this specific patient population


Supporting The Occupational Therapy Student In The Production And Dissemination Of Systematic Reviews: An Interprofessional Collaboration Among Librarians And Occupational Therapy Faculty, Teal W. Benevides, Phd, Otr/L, Paul Hunter, Dmd, Mlis, Gary E. Kaplan, Ms, Ahip, Daniel G. Kipnis, Msi May 2015

Supporting The Occupational Therapy Student In The Production And Dissemination Of Systematic Reviews: An Interprofessional Collaboration Among Librarians And Occupational Therapy Faculty, Teal W. Benevides, Phd, Otr/L, Paul Hunter, Dmd, Mlis, Gary E. Kaplan, Ms, Ahip, Daniel G. Kipnis, Msi

Department of Occupational Therapy Posters and Presentations

Objectives

This poster describes the outcomes of a curriculum-based collaboration between librarians and OT faculty (‘collaboration’) to enhance graduate student skills for conducting a systematic review (SR); the collaboration included database instruction, bibliographic management software, and culminated in student presentations to healthcare practitioners for continuing education credit. Three outcome areas are discussed: impact of the collaboration on student satisfaction and perceived competence; characteristics of the included literature; and the dissemination of SR findings to healthcare practitioners.

Methods

Three librarians participated in the instruction and the institutional repository (Jefferson Digital Commons; JDC) deposits. A total of 132 students over a period …


Consequence Of The Tumor-Associated Conversion To Cyclin D1b., Michael A Augello, Lisa D Berman-Booty, Richard Carr, Akihiro Yoshida, Jeffry L Dean, M J Schiewer, Felix Y Feng, Scott A Tomlins, Erhe Gao, Walter J Koch, Jeffrey L Benovic, John Alan Diehl, Karen E Knudsen May 2015

Consequence Of The Tumor-Associated Conversion To Cyclin D1b., Michael A Augello, Lisa D Berman-Booty, Richard Carr, Akihiro Yoshida, Jeffry L Dean, M J Schiewer, Felix Y Feng, Scott A Tomlins, Erhe Gao, Walter J Koch, Jeffrey L Benovic, John Alan Diehl, Karen E Knudsen

Department of Cancer Biology Faculty Papers

Clinical evidence suggests that cyclin D1b, a variant of cyclin D1, is associated with tumor progression and poor outcome. However, the underlying molecular basis was unknown. Here, novel models were created to generate a genetic switch from cyclin D1 to cyclin D1b. Extensive analyses uncovered overlapping but non-redundant functions of cyclin D1b compared to cyclin D1 on developmental phenotypes, and illustrated the importance of the transcriptional regulatory functions of cyclin D1b in vivo. Data obtained identify cyclin D1b as an oncogene, wherein cyclin D1b expression under the endogenous promoter induced cellular transformation and further cooperated with known oncogenes to promote …


Conference Poster Season, Daniel G. Kipnis, Msi Apr 2015

Conference Poster Season, Daniel G. Kipnis, Msi

Jefferson Digital Commons News

The Jefferson Digital Commons (JDC) has nearly 500 archived conference posters. Don’t let your conference posters collect dust and sit in hallways where only your colleagues view them on a daily basis. Send them to the JDC to reach a global audience.


Inside Out, Spring 2015 Apr 2015

Inside Out, Spring 2015

Inside Out

Contents:

Checkmate, Joshua Cannon, 1

Contort, Michael Natter, 2

For Vastness’ Sake, Marc McShane, 3

Old Country Road, Jonathan Elias, 4

Dippers, Ethan Sellers, 5

A Liberated Caravan, Tanziyah Muqeem, 6

To be, or Not to be, Danylo I. Holubnyk, 7

San Francisco, 2009, Sina Vahedi, 8

Tranquil Days, David Chou, 9

Living, Marc McShane, 10

Never Too Early for a Nap, Tuc To, 11

Reclining Nude, Chen Zhou,12

Peace Crane, Lauren Burgoon, 13

Untitled Hand, Amanda Joseph, 14

Japan Memorial, Lauren Burgoon, 15

The Clearing Storm, Eric W. Kostuk, 16

Wild Flowers, Amanda Joseph, 17

Female Nudes, Elise Campbell, …


Inside Out, Spring 2014 Apr 2015

Inside Out, Spring 2014

Inside Out

Contents

Angkor Thom: City of a Thousand Smiling Faces, Miranda G. Law, 1

Exposed Jade, Kami L. McManus, 2

Cheerleader Graffiti, Ethan Sellers, 3

Inca Beauty, Amy Tressan, 4

Ethereal, David Chou, 5

A Reflection, Sepehr Sedigh, 6

Mediumship, Michael Joseph Kolachny, Jr., RN 7

The Native Inspiration, Sepehr Sedigh, 8

Elephant, Julia Huntington, 9

Unrequited Love, Amy Tressan, 10

Wait, Nona Lu, 11

Clouds with Secrets, Amy Tressan, 12

Thunderstrike in Camden, Yuhang Zhou, 13

Crash, Diway Bermudez, 14

At Dusk I Carry Stones..., Ethan Sellers, 15

Docks at Jaffa, Kami L. McManus, 16

The Pier, David Chou, 17 …


Inside Out, Spring 2013 Apr 2015

Inside Out, Spring 2013

Inside Out

Contents:

Imp of the Perverse, Evan J. Slagle

Mom, Ethan Sellers

Curves of the Albatross, Christina Nguyen

Colors, Sarah Drejet

Rajasthan, India, Nishi Dedania

Heights that I Remember, Daniel Gealy

Girl in Transit, Michela Mickler

Chemo, Emily Fay

Energy, Dierdre Axell-House

African Dreaming, Michela Mickler

Flight, Michela Mickler Rittenhouse

Reflections, Kami L. McManus

Lovers in Washington Square, Wendy Diao

No Agenda, Laura Steel

I’ve Come to Know Sepia, Ethan Sellers

Re-imagine-d, Jonathan Elias

Glee, Rebecca Julian

A Creature Void of Form, Daniel Gealy

The Column, Emily Fay

Bold, Bald, Black & White, Dierdre Axell-House

Salar de Uyuni, Bolivia Nicholas Bishop …


Inside Out, Spring 2012 Apr 2015

Inside Out, Spring 2012

Inside Out

Contents

Limbless, Desmond Wilson, Cover

The Daily Grind, Dave Miller, Inside Cover

The Sea Conqueror, Jonathan Elias, 5

Fear, Yuliya Baratt, 5

Dreamer Mosaic, Huong Le, 6

The Colored White Desert of Egypt, MIranda Law, 6

The Hands of My First Autopsy, Nathan Fried, 7

Esperar, Neil Flannery Haidorfer, 8

Retrograde Frequency, Evan Slagle, 9

Childhood, Yuliya Baratt, 9

Flying South for the Winter, Nishi Dedania, 10

Barn in Winter, Michael Minckler, 10

Mountain Goat, Alissa Herman, 11

Tree Burr, Nate Jordan, 11

Wake, Andrea Frankenburger, 12

Mt. Rainier Viewed from Seattle, WA, Michael Minckler, 12

Sisterhood, Sharon Li, 13 …


Inside Out, Spring 2011 Apr 2015

Inside Out, Spring 2011

Inside Out

Contents:

Winter Boardwalk, Heather Tattersall, 1

Boundaries, Kanani Titchen, 2

Nightline, To Dung Nguyen, 4

Blue Jeans, Bonnie Bennet, 5

After the Genocide, Rwanda, Christine Chen, 6

Trails, Matt Richards, 7

Various Facades, Subhasree Basu, 8

On Our Mistakes, and Physics, Khalid Mohamood, 9

Valle Sagrado, Lara Murphy, 11

Pink Study, Han Koon Ooi, 12

Passage, Rites, Jennifer Lewis, 13

Layers, Mara Modest, 15

Heather Tattersall, Aivi Nguyen, 16

Pulse, Christina Furia, 17

Penmanship, Christina Nguyen, 18

Small Jeffersonians, Francina Girard, 19

Growing Up In Guatemala, Christine Chen, Front Cover

Lady Watering, Aimee J. Lee, Inside Front Cover

Singed, Matt …


Latest School Of Population Health Capstones In The Jdc, Daniel G. Kipnis, Msi Apr 2015

Latest School Of Population Health Capstones In The Jdc, Daniel G. Kipnis, Msi

Jefferson Digital Commons News

The latest round of capstone presentations by students in the TJU School of Population Health have been loaded in the Jefferson Digital Commons.


Cross-Cultural And Inter-Professional Knowledge Translation Of Developmentally Supportive Care In An Indian Nicu, Amy Carroll, Otd, Otr/L, Susan Toth-Cohen, Phd, Otr/L Apr 2015

Cross-Cultural And Inter-Professional Knowledge Translation Of Developmentally Supportive Care In An Indian Nicu, Amy Carroll, Otd, Otr/L, Susan Toth-Cohen, Phd, Otr/L

Department of Occupational Therapy Posters and Presentations

Synopsis:

A cross-cultural, and inter-professional NICU Team, including an American OT, used knowledge translation (KT) frameworks to apply current global evidence in developmentally supportive care in ways that were useful, cost effective, and meaningful to the families and staff in their tertiary care NICU setting in Gurgaon, India. The team used Pre & Post videotaping of routine care and procedures to measure the change in practice.

Objectives

1. Increase NICU nurses’ use of DSC during routine care and procedures

2. Decrease the use of non-supportive behaviors


Embedding Mindfulness Practice In Entry-Level Occupational Therapy Education Program: Experiences And Outcomes, Mary Muhlenhaupt, Otd, Otr/L, Faota, Shelly Wallock, Dr.P.H., Otr/L Apr 2015

Embedding Mindfulness Practice In Entry-Level Occupational Therapy Education Program: Experiences And Outcomes, Mary Muhlenhaupt, Otd, Otr/L, Faota, Shelly Wallock, Dr.P.H., Otr/L

Department of Occupational Therapy Posters and Presentations

Objective:

To embed mindfulness practice into an entry-level occupational therapy curriculum and assess outcomes to reduce student stress and promote well-being.


Experiential Global Health Education For The Health Professions: Lessons Learned From Experience-Based Learning For Students And Healthcare And Population Health Professionals, Rob Simmons, Drph, Mph, Mches, Cph, James Plumb, Md, Mph, Lucille Pilling, Edd, Mph, Rn, Ellen Plumb, Md Apr 2015

Experiential Global Health Education For The Health Professions: Lessons Learned From Experience-Based Learning For Students And Healthcare And Population Health Professionals, Rob Simmons, Drph, Mph, Mches, Cph, James Plumb, Md, Mph, Lucille Pilling, Edd, Mph, Rn, Ellen Plumb, Md

College of Population Health Lectures, Presentations, Workshops

Purpose:

  • Describe key components of developing and sustaining a global health experiential learning experience
  • Global Health Education for the Health Professions
  • An area for multi-disciplinary study, research, and practice that places priority on achieving equity in health for all people worldwide
  • Emphasizes transnational health issues, determinants, and solutions that promote interdisciplinary collaboration providing a synthesis of population based prevention, often including individual-level education and healthcare


Phylogenetic Tree Construction And “Truncal Loss” Analysis Reveal Hidden Associations Between Loss Of Protein Expression In Swi/Snf Complex Components And Tumor Stage And Survival In Clear Cell Renal Cell Carcinoma (Ccrcc), Wei Jiang, Md, Phd, Essel Dulaimi, Karthik Devarajan, Qiong Wang, Raymond O'Neill, Charalambos C. Solomides, Md, Stephen C Peiper, Phd, Robert Uzzo, Joseph R. Testa, Haifeng Yang, Phd Apr 2015

Phylogenetic Tree Construction And “Truncal Loss” Analysis Reveal Hidden Associations Between Loss Of Protein Expression In Swi/Snf Complex Components And Tumor Stage And Survival In Clear Cell Renal Cell Carcinoma (Ccrcc), Wei Jiang, Md, Phd, Essel Dulaimi, Karthik Devarajan, Qiong Wang, Raymond O'Neill, Charalambos C. Solomides, Md, Stephen C Peiper, Phd, Robert Uzzo, Joseph R. Testa, Haifeng Yang, Phd

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Background

Polybromo-1 (PBRM1), a targeting subunit of the SWI/SNF chromatin remodeling complex, is mutated at a rate of ~40% in clear cell Renal Cell Carcinoma (ccRCC), second only to VHL. Whether its mutation is correlated with tumor stage is controversial. As other components of the SWI/SNF complex were also reported to be mutated in ccRCC, we aim to examine the protein expression patterns of PBRM1, ARID1A, BRG1, and BRM in ccRCC, and to investigate possible association between their loss of expression and tumor stage, as well as survival. We also included a histone modifier, SETD2, which is recently discovered to …


Assessment For Risk Factors Associated With Local Recurrence In Chordoma, John A. Abraham, Md, Wei Jiang, Md, Phd Apr 2015

Assessment For Risk Factors Associated With Local Recurrence In Chordoma, John A. Abraham, Md, Wei Jiang, Md, Phd

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Background

Chordoma is a rare but locally aggressive malignant neoplasm showing notochordal differentiation. The clinical differential diagnoses can be extensive, and definitive diagnosis often relies on histopathologic evaluation. Histologically, chordoma shows dual epithelial and mesenchymal differentiation, with various morphologies. Despite surgical resection and use of adjuvant radiation therapy, the local recurrence rate of chordoma remains high. We aim to establish factors associated with the increased risk of recurrence and help guide treatment decisions.


Age-Related Ebv-Associated Lymphoproliferative Disorder With Widespread Gastrointestinal Involvement And Subsequent Development Of T-Cell Lymphoma, Guldeep Uppal, Md, Alaina Chodoff, Msii, Zi-Xuan Wang, Phd, Jeffrey P. Baliff Md, Jerald Z. Gong, Md Apr 2015

Age-Related Ebv-Associated Lymphoproliferative Disorder With Widespread Gastrointestinal Involvement And Subsequent Development Of T-Cell Lymphoma, Guldeep Uppal, Md, Alaina Chodoff, Msii, Zi-Xuan Wang, Phd, Jeffrey P. Baliff Md, Jerald Z. Gong, Md

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Background

Age-related EBV-associated lymphoproliferative disorder (AR-EBVLPD) has emerged as a new subset of B-cell lymphoproliferative disorders. We report a unique case of AR-EBVLPD with a widespread gastrointestinal presentation and subsequent transformation to EBV-associated T-cell lymphoma. To our knowledge, this is the first report of a generalized polymorphic extranodal AR-EBVLPD with subsequent transformation to EBV-induced T-cell lymphoma.


Pathology Encountered During Cadaver Dissection Provides An Opportunity For Integrated Learning And Critical Thinking, Guiyan Zhang, Bruce Fenderson Apr 2015

Pathology Encountered During Cadaver Dissection Provides An Opportunity For Integrated Learning And Critical Thinking, Guiyan Zhang, Bruce Fenderson

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Abstract

Cadaver dissection engages medical students in active learning, critical thinking, and problem solving. During dissection, students at SKMC are encouraged to document pathologic findings in their cadavers and discuss the findings with their peers. Here, we describe two cases that provided opportunities for integrating anatomy with pathology and clinical medicine. The first case was a benign ovarian neoplasm. This large pelvic mass displaced the urinary bladder and uterus, and compressed the ureters and rectum. Students discussed clinical complications of this pelvic mass and reviewed pathologic findings that differentiate benign from malignant neoplasms. The second case was breast cancer with …


An Assessment Of The Reliability Of Platelet-Associated Flags Generated By The Sysmex Xe-5000 Automated Hematology Analyzer In Detecting Platelet Clumps, Jennifer M. Hawkins, Do, Gene Gulati, Ph.D, Guldeep Uppal, Md, Jerald Z. Gong, Md Apr 2015

An Assessment Of The Reliability Of Platelet-Associated Flags Generated By The Sysmex Xe-5000 Automated Hematology Analyzer In Detecting Platelet Clumps, Jennifer M. Hawkins, Do, Gene Gulati, Ph.D, Guldeep Uppal, Md, Jerald Z. Gong, Md

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Background

XE-5000 is an automated hematology analyzer utilized by clinical laboratories worldwide to perform CBC and differential leukocyte counts on EDTA-anticoagulated blood specimens. The overall reliability of the results generated by this analyzer has been assessed and found acceptable for clinical use. The CBC results generated on some of the blood specimens are, however, flagged by the analyzer for verification of the result of the flagged parameter by other means. One such parameter of clinical significance is the automated platelet count, which is often unreliable if the blood specimen contains platelet clumps.


Loss Of Expression Of Swi/Snf Chromatin Remodeling Complex Components And Setd2 Are Heterogeneous, Widespread, And Co-Occur In Clear Cell Renal Cell Carcinoma, Wei Jiang, Md, Phd, Essel Dulaimi, Theodore Parsons, Qiong Wang, Karthik Devarajan, Raymond O'Neill, Charalambos C. Solomides, Md, Stephen C Peiper, Phd, Jospeh R. Testa, Robert Uzzo, Haifeng Yang Apr 2015

Loss Of Expression Of Swi/Snf Chromatin Remodeling Complex Components And Setd2 Are Heterogeneous, Widespread, And Co-Occur In Clear Cell Renal Cell Carcinoma, Wei Jiang, Md, Phd, Essel Dulaimi, Theodore Parsons, Qiong Wang, Karthik Devarajan, Raymond O'Neill, Charalambos C. Solomides, Md, Stephen C Peiper, Phd, Jospeh R. Testa, Robert Uzzo, Haifeng Yang

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Background

The subunits of the SWI/SNF chromatin remodeling complex have one of the highest mutation rate in human cancers (see Figure 1). Polybromo-1 (PBRM1), a subunit of the SWI/SNF complex, is the second most mutated gene (40%) in clear cell Renal Cell Carcinoma (ccRCC). ARID1A, another subunit that competes with PBRM1 for binding to the complex, was infrequently mutated. The protein expressions of BRG1 and BRM (two catalytic subunits of the complex), and SETD2, a histone modifier (10-15% mutation rate), are not known in ccRCC. In this study we examined their protein expressions by immunohistochemistry (IHC) in tissue microarrays (TMAs), …


Crosstalk Between Desmoglein 2 And Patched 1 Accelerates Chemical-Induced Skin Tumorigenesis., Donna M Brennan-Crispi, Claudia Hossain, Joya Sahu, Mary Brady, Natalia A Riobo, M G Mahoney Apr 2015

Crosstalk Between Desmoglein 2 And Patched 1 Accelerates Chemical-Induced Skin Tumorigenesis., Donna M Brennan-Crispi, Claudia Hossain, Joya Sahu, Mary Brady, Natalia A Riobo, M G Mahoney

Department of Biochemistry and Molecular Biology Faculty Papers

Aberrant activation of Hedgehog (Hh) signaling is causative of BCCs and has been associated with a fraction of SCCs. Desmoglein 2 (Dsg2) is an adhesion protein that is upregulated in many cancers and overexpression of Dsg2 in the epidermis renders mice more susceptible to squamous-derived neoplasia. Here we examined a potential crosstalk between Dsg2 and Hh signaling in skin tumorigenesis. Our findings show that Dsg2 modulates Gli1 expression, in vitro and in vivo. Ectopic expression of Dsg2 on Ptc1+/lacZ background enhanced epidermal proliferation and interfollicular activation of the Hh pathway. Furthermore, in response to DMBA/TPA, the Dsg2/Ptc1+/lacZ mice developed squamous …


An Interprofessional, Tailored Behavioral Intervention For Sleep Problems In Autism: Use Of Sensory Data To Inform Intervention, Rebecca Sinko, Ms, Otr/L, Sarah E. Kauper, Bs, Ots, Phoi Truong, Bs, Ots, Rachel L. Dumont, Bs, Ots, Amy L. Miller, Bs, Ots, Roseann C. Schaaf, Phd, Otr/L, Faota, Margaret Souders, Phd, Crnp, Eric D. Bull, Ots, Denise G. Doria, Ots, Jamie A. Frank, Ots, Jenna R. Grady, Ots Apr 2015

An Interprofessional, Tailored Behavioral Intervention For Sleep Problems In Autism: Use Of Sensory Data To Inform Intervention, Rebecca Sinko, Ms, Otr/L, Sarah E. Kauper, Bs, Ots, Phoi Truong, Bs, Ots, Rachel L. Dumont, Bs, Ots, Amy L. Miller, Bs, Ots, Roseann C. Schaaf, Phd, Otr/L, Faota, Margaret Souders, Phd, Crnp, Eric D. Bull, Ots, Denise G. Doria, Ots, Jamie A. Frank, Ots, Jenna R. Grady, Ots

Department of Occupational Therapy Posters and Presentations

Purpose:

The purpose of this poster is to demonstrate how Sensory Profile data informed occupational therapy sleep interventions for two participants as part of an Interprofessional Tailored Behavioral Intervention study.