Medicine and Health Sciences Commons^™

Effects Of Weight Loss Induced By Eight-Week Orlistat Therapy On Maximal Work Production Capacity In Obese Females, Oğuz Özçeli̇k, Hali̇l Doğan, Haluk Keleşti̇mur

Turkish Journal of Medical Sciences

The aim of this study was to examine the effects of weight loss induced by pharmacotherapy combined with a hypocaloric diet for a period of 8-weeks on maximal work (Wmax) production capacity and aerobic fitness in obese patients. Twelve obese females were put on an integrated energy restricted diet with orlistat supplement 3 x 120 mg/day. Each patient performed 3 incremental ramp exercise tests using an electromagnetically braked cycle ergometer: one at onset, one at the end of 4-weeks and one at the end of the 8-weeks to determine Wmax production capacity. The first 4-week therapy period resulted in a …

Thinking Beyond Health To Motivate Dietary Change: Piloting A Vegan Healthy Eating Program For Obesity Management, Mark Alan Berman

Yale Medicine Thesis Digital Library

This pilot study assessed the feasibility, acceptability and efficacy of a novel approach to facilitating dietary change and weight loss in obese adults by presenting vegan environmental, health and farm animal treatment information in a 6 week, group-based, educational nutrition program (called a vegan healthy eating program). Twenty-nine (29) medically stable, obese adults were recruited from 3 ambulatory care clinics at UCSF and enrolled using partial randomization into one of two serially occurring intervention groups (Group 1 n=14, followed by Group 2 n=15). A delayed intervention control group (n=9) was used, consisting of participants enrolled in Group 2 who were …

Change In Diet, Physical Activity, And Body Weight In Female College Freshman, Scott M. Butler, David R. Black, Carolyn L. Blue, Randall J. Gretebeck

College of Nursing Faculty Research and Publications

Objective: To examine diet, physical activity, and body-weight changes associated with relocation from home to university.

Methods: Diet, fitness/physical activity, body-weight parameters and self-efficacy were assessed among 54 freshman women upon college entry and 5 months later.

Results: Although caloric intake significantly decreased, a significant increase occurred in body-weight parameters that may be attributed to significant decreases in total physical activity.

Conclusions: Interventions are needed aimed at increasing physical activity; improving diet quality related to consumption of vegetables, fruits, breads and pasta, and meats; and decreasing alcohol consumption.

Body Image And Attitudes Toward Obesity In College Students, Sarah Rebecca Goodwin

Theses and Dissertations

The current study was conducted in order to examine the impact of ethnicity on gender differences in body type preferences and perceptions and add to the literature examining racial differences in body type preferences and perceptions. The current study was an expansion of one by Gipson et al conducted at a historically Black university in 2004, in which responses and BMI measurements of 191 college students were examined for associations between BMI and gender, and body image and attitudes toward obesity. For the current study the sample of 176 college students enrolled at Virginia Commonwealth University, an ethnically diverse institution, …

Knowledge, Attitude And Practice Regarding Obesity Among Patients, At Aga Khan University Hospital, Karachi, Waris Qidwai, Iqbal Azam

Department of Family Medicine

BACKGROUND: Obesity is a major public health problem and responsible for significant morbidity and mortality among our patients. It is important to study the knowledge, attitude and practices with regard to obesity among patients, in order to devise interventional strategies.
METHODS: Patients visiting the out-patient clinics of Aga Khan University Hospital, Karachi, were included in the study. The interview was questionnaire-based and recorded the demographic profile of the patients and questions relevant to the objective of the study. The ethical requirements for the study were met. SPSS computer software was used for data management. A hundred patients were surveyed. …

Considering Physical Inactivity In Relation To Obesity, Janet C. Struber

Internet Journal of Allied Health Sciences and Practice

Physical inactivity and obesity contribute enormously to the current burden of disease in Australia, as in all Western Countries. Although diet and exercise have been linked to health since antiquity, the connection has recently experienced a revival of interest. There is mounting evidence that the current prevalence of obesity is more closely related to decreases in energy expenditure than to the traditionally accepted imbalance between consumption and expenditure, and that physical activity is therefore crucial in maintaining weight loss. With overweight[1] and obesity[2] now the norm in Australia, physical inactivity is a major issue within and beyond the health sector, …

Association Between The Frequency Of Physical Education Classes And The Prevalence Of Overweight/Obesity In Adolescents, Collin N. Rice

Theses and Dissertations

Background/Objective: Overweight and obesity has been steadily on the rise in the United States for all groups. The prevalence of obesity for adolescents has tripled since 1980. The purpose of this study is to determine an association between the frequency of physical education classes and the prevalence of overweight/obesity in adolescents in the United States.Methods: This was a cross-sectional study that used the 2001 Youth Risk Behavior Survey (YRBS) of the Center for Disease Control. The outcome variable for the study was Body Mass Index (BMI). A BMI of 25 or greater was considered overweight or obese. The main independent …

Obesity And Health Status Among Urban Vs. Suburban Elderly In Philadelphia And Surrounding Counties, Ockidde Dufayne Harris

Theses and Dissertations

Obesity is a dangerous health condition affecting approximately 30% of all Americans and can be attributed to 300,000 deaths a year. Obesity has been found to disproportionately affect Blacks, Latinos, and those with lower SES. Although obesity is a problem for all age groups, its prevalence is highest among those 60-74 years of age. Studies have shown that there is an association between obesity and chronic conditions such as cardiovascular disease, arthritis, cancers, and type-2 diabetes. According to the Centers for Disease Control, chronic health conditions affect 80% of all elderly persons, many times limiting function and decreasing quality of …

Adiponectin Expression From Human Adipose Tissue: Relation To Obesity, Insulin Resistance, And Tumor Necrosis Factor-Α Expression, Philip A. Kern, Gina B. Di Gregorio, Tong Lu, Negah Rassouli, Gouri Ranganathan

Clinical and Translational Science Faculty Publications

Adiponectin is a 29-kDa adipocyte protein that has been linked to the insulin resistance of obesity and lipodystrophy. To better understand the regulation of adiponectin expression, we measured plasma adiponectin and adipose tissue adiponectin mRNA levels in nondiabetic subjects with varying degrees of obesity and insulin resistance. Plasma adiponectin and adiponectin mRNA levels were highly correlated with each other (r = 0.80, P < 0.001), and obese subjects expressed significantly lower levels of adiponectin. However, a significant sex difference in adiponectin expression was observed, especially in relatively lean subjects. When men and women with a BMI2were compared, women had a twofold higher percent body fat, yet their plasma adiponectin levels were 65% higher (8.6 ± 1.1 and 14.2 ± 1.6 μg/ml in men and women, respectively; P < 0.02). Plasma adiponectin had a strong association with insulin sensitivity index (S_I) (r = 0.67, P < 0.0001, n = 51) that was not affected by sex, but no relation with insulin secretion. To separate the effects of obesity (BMI) from S_I, subjects who were discordant for S_I were matched for BMI, age, and sex. Using this approach, insulin-sensitive subjects demonstrated a twofold higher plasma level of …

Portion Distortion Plays A Major Role In The American Obesity Epidemic, Amanda Kay Larsen

Undergraduate Honors Capstone Projects

The prevalence of overweight and obesity among the American population is on the rise. This epidemic can be attributed to an increase in energy intake. Research has shown that increased consumption is associated with both individual and societal factors including an increase in the size of portions, the influence of the food industry, and confusion on the part of the consumer. The findings indicate that dietitians and other healthcare providers need to do their part by informing society of the importance of decreasing portions and helping the consumer recognize appropriate portion sizes.

The Characterization Of Two Differentially Expressed Plasma Proteins In Obese Versus Lean Rats In Two Rodent Models Of Obesity, Roger D. Boggs

Theses, Dissertations and Capstones

Zucker fa and La/N faf rats are widely studied models of genetic obesity and its complications. These two rodent models of obesity were utilized to search for a circulating protein marker for obesity. Plasma samples from both of these models of obesity were collected and analyzed via SDS-PAGE analysis. Two proteins were found which demonstrate differential expression between lean and obese rats. Both proteins demonstrated increased expression in the obese rats compared to the lean. One differentially expressed protein migrated on SDS-PAGE gels at 116 KD while the second migrated at 22 KD compared to molecular weight markers. The 22 …

Nutrition And Disability, Kathleen Humphries, Meg Traci, Tom Seekins Ph.D., Joyce Brusin, University Of Montana Rural Institute

Health and Wellness

A disability often can be complicated by additional medical, psychological, or environmental problems. Under an emerging framework of health promotion for persons with disabilities, these additional health problems are referred to as secondary conditions (Brandt & Pope, 1997; Marge, 1988; Pope & Tarlov, 1991). Until recently, it was common to conceptualize these ailments as symptomatic of the primary disability; however, it is now presumed that because these conditions can be prevented or managed, they are secondary conditions distinct from the primary disability. Although information on secondary conditions experienced by people with developmental disabilities is limited, the literature does contain descriptions …

Effects Of Short-Term Orlistat Therapy On Maximal Power Production Capacity In Obese Patients, Oğuz Özçeli̇k, Rami̇s Çolak, A. Baki̇ Türkoğlu

Turkish Journal of Medical Sciences

The aim of this study was to examine the effects of weight loss induced by hypocaloric diet and orlistat therapy for a four-week period on maximal work rate (Wmax) production capacity and aerobic fitness in obese patients. Fifteen obese subjects were given an integrated energy restricted diet and orlistat supplement (DO). Each patient performed two incremental ramp exercise tests using an electromagnetically braked cycle ergometer: one at the beginning and one at the end of the four-weeks to determine Wmax production capacity. Four weeks of DO therapy resulted in a significant reduction in total body weight (93.7 ± 14.6 kg …

Fear Of Fatness Among Young Irish Adolescents : Association With Obesity, Reported Iron And Folate Intake, And Dental Health, Anne C. Griffin

Doctoral

OBJECTIVE: To establish the prevalence of fear of fatness (the desire to be thinner) and associated factors, including obesity, reported energy, iron and folate intakes. The difficulties in defining overweight among Irish children and an assessment of dietary and socio-economic factors related to dental caries and also reported in the group. METHODS: A one-year follow up study of 251 healthy schoolchildren at baseline (119 boys and 132 girls; mean age 11 years) attending 7 fee-paying (6 single- and 1-mixed sex) and 8 non-fee-paying (4 single- and 4 mixed-sex) schools in Dublin city center. Assessment of body image perceptions and satisfaction …

Characteristics And Attitude Of Contraceptive Acceptorsamong Adolescents Attending The Family Planningclinic At King Chulalongkorn Memorial Hospital, S. Bunyavejchevin, W. Wisawasukmongchol, U. Jaisamran, D. Reinprayoon

Chulalongkorn Medical Journal

No abstract provided.

Role Of Lipolysis And Lipogenesis In The Development Of Diet-Induced Obesity, Michael John Davies

Theses and Dissertations in Biomedical Sciences

Obesity is an increasingly common public health problem with approximately one-half of the American adult population overweight and one-quarter considered obese. This alarming trend has led researchers to determine potential causative factors of excess weight gain in humans. However, it is difficult to discern whether perturbations that result in obesity are the cause or simply the result of the obese state. Diet-induced obesity is one of the animal models that allow researchers to address temporal issues. Our laboratory utilizes a diet-induced obesity model in which Sprague-Dawley rats are placed on a purified moderately high fat diet and ultimately diverge into …

Obesity And The Activity Of The Autonomicnervous System, Rami̇s Çolak, Emi̇r Dönder, Azi̇z Karaoğlu, Oğuz Ayhan, Mehmet Yalniz

Turkish Journal of Medical Sciences

This study was conducted to examine the autonomic nervous system functions of obese people. The study group consisted of 30 healthy obese people (20 female, 10 male, age range 18-58, median 37.6±9.7 years of age) and the control group consisted of 30 healthy nonobese people (18 female, 12 male, age range 17- 56, median 34.4±7.5 years). Each function was tested by non-invasive applications (orthostatic test, isometric exercise test, Valsalva ratio test, 30/15 ratio test, heart rate change test by deep respiration). The results of the orthostatic test and isometric- exercise test yielded a statistically significant difference between the study and …

Pulmonary Effects Of Dexfenfluramine, Ferhan Candan, Melih Kaptanoğlu, Reyhan Egi̇lmez, Kasim Doğan, Metin Aksoy, Yücel Yalman, Ebuzer Bekar, Füsun Gülteki̇n

Turkish Journal of Medical Sciences

Dexfenfluramine is a variation of fenfluramine which is used for weight reduction. The aim of the study is to determine the hemodynamic and structural effects of this drug on pulmonary circulation. An experimintal study was carried out with New Zealand Rabbits. A control group (n=30) and an experimintal group (n=20) was constituted. A four-week normal diet for control group and dexfenfluramine plus normala diet for experimental group were applied. Body weights and pulmonary artery pressures of groups were recorded and lungs were collected for pathologic examination. In experimintal group; Dexfenfluramine raised systolic pulmonary artery pressures significantly (p0.05). Weight reduction was …

Potential Role Of Tnfα And Lipoprotein Lipase As Candidate Genes For Obesity, Philip A. Kern

Clinical and Translational Science Faculty Publications

To maintain body weight, metabolic efficiency was promoted during evolution; two candidate genes for body weight regulation are lipoprotein lipase (LPL) and tumor necrosis factor-α [TNFα). Human fat cells do not synthesize lipid, but rely on LPL-mediated plasma triglyceride hydrolysis. Adipose LPL is elevated in obesity. Following weight loss, LPL is elevated further, suggesting attempts to maintain lipid stores during fasting and to replenish lipid stores during refeeding. Muscle LPL is regulated inversely to adipose LPL. Thus, an increased adipose/muscle LPL ratio would partition dietary lipid into adipose tissue and would explain some of the variability in weight gain when …

Increased Abundance Of The Receptor-Type Protein-Tyrosine Phosphatase Lar Accounts For The Elevated Insulin Receptor Dephosphorylating Activity In Adipose Tissue Of Obese Human Subjects, Falyaz Ahmad, Robert V. Considine, Barry J. Goldstein

Department of Medicine Faculty Papers

Protein-tyrosine phosphatases (PTPases) have an essential role in the regulation of the steady-state phosphorylation of the insulin receptor and other proteins in the insulin signalling pathway. To examine whether increased PTPase activity is associated with adipose tissue insulin resistance in human obesity we measured PTPase enzyme activity towards the insulin receptor in homogenates of subcutaneous adipose tissue from a series of six lean and six nondiabetic, obese (body mass index > 30) subjects. The obese subjects had a mean 1.74-fold increase in PTPase activity (P < 0.0001) with a striking positive correlation by linear regression analysis between PTPase activity and body mass index among all of the samples (R = 0.918; P < 0.0001). The abundance of three candidate insulin receptor PTPases in adipose tissue was also estimated by immunoblot analysis. The most prominent increase was a 2.03-fold rise in the transmembrane PTPase LAR (P < 0.001). Of the three PTPase examined, only immunodepletion of LAR protein from the homogenates with neutralizing antibodies resulted in normalization of the PTPase activity towards the insulin receptor, demonstrating that the increase in LAR was responsible for the enhanced PTPase activity in the adipose tissue from obese subjects. These studies suggest that increased PTPase activity towards the insulin receptor is a pathogenetic factor in the insulin resistance of adipose tissue in human obesity and provide evidence for a potential role of the LAR PTPase in the regulation of insulin signalling in disease states.

The Relationship Between Diet, Activity, And Other Factors, And Postpartum Weight Change By Race, Debra J. Boardley, Roger G. Sargent, Ann L. Coker, James R. Hussey, Patricia A. Sharpe

CRVAW Faculty Journal Articles

Objective: To identify the impact of dietary intake and activity level on postpartum weight change.

Methods: White (n = 121) and black (n = 224) women, 7-12 months postpartum, participating in the Special Supplemental Feeding Program for Women, Infants, and Children were assessed for dietary intake, activity level, body weight, and other maternal characteristics.

Results: For both black and white women, the most important variables in predicting postpartum weight loss were pre-pregnancy weight, gestational weight gain, parity, and prenatal exercise. After these factors were controlled, race predicted that black women retained 6.4 lb more than white women. These results may …

Factors Related To Self-Care Agency And Self-Care Practices Of Obese Adolescents, Kathy Shadle James Dnsc, Msn, Rn

Dissertations

Identification of factors that influence obese adolescents' health behaviors is necessary if obese adolescents are to benefit from therapeutic interventions. The purpose of this descriptive-correlational study was to identify the relationships between selected basic conditioning factors (BCFs)--perceived health status (PHS), perceived self-efficacy (PSE), family satisfaction (FS), and life events (LE)--and the self-care agency (SCA) and self-care practices (SCP) among obese adolescents. The relative predictive strength of each BCF in relation to the outcome variables was also explored. Orem's self-care theory provided the conceptual framework for this study. The convenience sample of 100 obese adolescents included campers from two southern California …

An Obsessive-Compulsive View Of Obesity And Its Treatment, Raymond Mount, Fugen Neziroglu, Christina J. Taylor

Psychology Faculty Publications

It was hypothesized that some obese individuals who are obsessed with food and who eat compulsively may not respond to the stimulus control techniques widely used in treating obesity. Sixty-eight participants were ad- ministered a measure of obsessive tendencies and randomly assigned to three treatment modalities: (a) Exposure and response prevention; (b) Stimulus control; (c) Control. Results indicated that participants who scored high on the Eating Obsessive Compulsive questionnaire (EOC) maintained weight loss significantly better with exposure and response prevention (ERP) training than did either the stimulus control or the control group. It was concluded that for the obsessive-compulsive eater, …

Genetic And Environmental Factors In Obesity: Case Studies, Bonnie Kathleen Hargis

Theses

This research project consisted of seven case studies of obese women who sought treatment for their weight problems at a hospital weight loss clinic and fitness center. The purpose of these studies was to consider the extent to which heredity and /or environmental factors contributed to these subjects being overweight. The case studies suggested that six of the subjects' overweight. problems were mainly caused by environmental factors. It was determined that one subject was overweight largely due to genetic predisposition, but that environmental factors also played a role. The two primary environmental factors appeared to be eating large portions of …

A Survey Of Menstrual Symptoms Of Obese Women, Ruthie Smith

MSN Research Projects

A descriptive study was conducted to survey females who are obese and determine what problems they encounter with menses. The researcher hypothesized that when obese women are surveyed about menstrual problems and the degree of obesity is correlated to the presence of menstrual problems, there would be no significant correlation. In order to facilitate testing of this hypothesis, two operational hypotheses were drafted. The first operational hypothesis was that when the total number of menstrual problems was correlated with the degree of obesity there would be no significant correlation. The second operational hypothesis was that when menstrual problems were individually …

Body Composition And Its Outcomes And Management In Multiple Sclerosis: Narrative Review, H W Van Landuyt, J Boelaert, P Piot, L Verbist

Faculty, Staff and Student Publications

Background: There is emerging interest in obesity and its prevalence, outcomes, and management in people with multiple sclerosis (MS). Body mass index (BMI) is the traditional marker of obesity in MS, whereas body composition, inclusive of specific body tissue compartments (e.g., fat, bone, and muscle), is often overlooked despite its relevance.

Objective: This narrative review (a) underscored the use and utility of dual-energy X-ray absorptiometry (DEXA) as an accurate and reliable measure of body composition; (b) thematically analyzed and synthesized the current evidence regarding body composition (using DEXA); and (c) determined gaps to be addressed in future research.

Methods: The …

The Incidence Of Obesity In Lds College Women: The Effect Of Selected Physical Socio-Environmental Variables On Total Percent Body Fat In Two Populations Of Lds Women, Carrie Tanner Summers

Theses and Dissertations

The purpose of this study was to determine the effect of selected physical socio-environmental variables on total percent body fat. The sample population consisted of single, LDS, white women attending Brigham Young University (BYU) and California State University at Fullerton (CSUF). Significant data as well as trends that appeared were included in this paper.

From the data collected, it was concluded that the sample populations at BYU and CSUF were the same. The incidence of obesity was determined only among individuals attending both universities. The entire sample population mean was 22.19 percent. This percentage did not meet the obesity criteria. …

Exercise And Eating Habit Change In The Treatment Of Obesity, Michael D. Johnson

University of the Pacific Theses and Dissertations

A pretest-posttest control group design was used to compare the effectiveness of a behavioral caloric reduction/exercise increase treatment package with a caloric reduction approach. The participants consisted of 32 people selected from those responding to a community newspaper advertisement announcing the weight control program. The caloric reduction/exercise treatment group focused on energy expenditure methods for reducing weight and improving physical fitness along with procedures for controlling food intake patterns. The caloric reduction group concentrated on procedures for controlling food intake patterns only. The results indicated that weight loss was achieved by both the caloric reduction group and the combined caloric …

Causes Of Obesity, Barbara Brown

Honors Theses

The preoccupation with obesity finds expression in the popularity of books and articles dealing with dieting and weight control, the rapid growth of weight reduction groups such as Tops and Weight Watchers, as well as the full marketing of numerous low calorie and dietetic foods. Much of the interest in weight control is a consequence of the current standards of physical beauty in our society. But another more pressing reason for interest in weight control is the documented evidence relating obesity to various somatic disorders.