Medicine and Health Sciences Commons^™

Website Usage And Weight Loss In A Free Commercial Online Weight Loss Program: Retrospective Cohort Study, Kevin O Hwang, Jing Ning, Amber W Trickey, Christopher N Sciamanna

Faculty, Staff and Student Publications

BACKGROUND: Online weight loss programs are increasingly popular. However, little is known about outcomes and associations with website usage among members of free online weight loss programs.

OBJECTIVE: This retrospective cohort study examined the association between website usage and weight loss among members of a free commercial online weight loss program (SparkPeople).

METHODS: We conducted a retrospective analysis of a systematic random sample of members who joined the program during February 1 to April 30, 2008, and included follow-up data through May 10, 2010. The main outcome was net weight change based on self-reported weight. Measures of website usage included …

The Influence Of Obesity On The Outcome Of Treatment Of Lumbar Disc Herniation: Analysis Of The Spine Patient Outcomes Research Trial (Sport)., Jeffrey A Rihn, Mark Kurd, Alan S Hilibrand, Jon Lurie, Wenyan Zhao, Todd Albert, James Weinstein

Rothman Institute Papers

BACKGROUND: Questions remain as to the effect that obesity has on patients managed for symptomatic lumbar disc herniation. The purpose of this study was to determine if obesity affects outcomes following the treatment of symptomatic lumbar disc herniation.

METHODS: An as-treated analysis was performed on patients enrolled in the Spine Patient Outcomes Research Trial for the treatment of lumbar disc herniation. A comparison was made between patients with a body mass index of/m² (nonobese) (n = 854) and those with a body mass index of ≥30 kg/m² (obese) (n = 336). Baseline patient demographic and clinical characteristics were documented. Primary …

The Healthy Lifestyle Center: A Case Study Illustrating The Opportunities And Challenges Confronting Local Health Departments In Preventing Chronic Disease, Katherine Anne Kemper Blossom

Master of Public Health Program Student Publications

Obesity is at epidemic levels in the United States, and is directly associated with decreased life expectancy, reduced quality of life, and increased health care costs. Public health system partners agree that reversing obesity trends will require a concerted effort led by government as well as business and civic organizations and that a multi-faceted approach will be needed to transform communities into places where the healthy choice becomes the easy choice for everyone. A foundational role for local health departments is to promote healthy behaviors. Public Health – Dayton & Montgomery County (PHDMC) has a history of providing community-based health …

Empiric Guideline-Recommended Weight-Based Vancomycin Dosing And Nephrotoxicity Rates In Patients With Methicillin-Resistant Staphylococcus Aureus Bacteremia: A Retrospective Cohort Study, Ronald G. Hall Ii, Kathleen A. Hazlewood, Sara D. Brouse, Christopher A. Giuliano, Krystal K. Haase, Chistopher R. Frei, Nicolas A. Forcade, Todd Bell, Roger J. Bedimo, Carlos A. Alvarez

Wayne State University Associated BioMed Central Scholarship

Abstract

Background

Previous studies have established a correlation between vancomycin troughs and nephrotoxicity. However, data are currently lacking regarding the effect of guideline-recommended weight-based dosing on nephrotoxicity in methicillin-resistant Staphylococcus aureus bacteremia (MRSAB).

Methods

Adults who were at least 18 years of age with methicillin-resistant Staphylococcus aureus bacteremia and received of empiric vancomycin therapy for at least 48 hours (01/07/2002 and 30/06/2008) were included in this multicenter, retrospective cohort study. The association between guideline-recommended, weight-based vancomycin dosing (at least 15 mg/kg/dose) and nephrotoxicity (increase in serum creatinine (SCr) by more than 0.5 mg/dl or at least a 50% increase from …

Cam Use Among Overweight And Obese Persons With Radiographic Knee Osteoarthritis, Kate L. Lapane, Shibing Yang, Rachel Jawahar, Timothy Mcalindon, Charles B. Eaton

Family Medicine and Population Health Publications

Background

Obesity is associated with knee pain and is an independent predictor of incident knee osteoarthritis (OA); increased pain with movement often leads patients to adopt sedentary lifestyles to avoid pain. Detailed descriptions of pain management strategies by body mass index (BMI) level among OA patients are lacking. The objectives were to describe complementary and alternative medicine (CAM) and conventional medication use by BMI level and identify correlates of CAM use by BMI level.

Methods

Using Osteoarthritis Initiative baseline data, 2,675 patients with radiographic tibiofemoral OA in at least one knee were identified. Use of CAM therapies and conventional medications …

Differences In Demographic, Behavioral, And Biological Variables Between Those With Valid And Invalid Accelerometry Data: Implications For Generalizability, Paul D. Loprinzi, Bradley J. Cardinal, Carlos J. Crespo, Gary R. Brodowicz, Ross E. Andersen, Ellen Smit

Community Health Faculty Publications and Presentations

Background: The exclusion of participants with invalid accelerometry data (IAD) may lead to biased results and/or lack of generalizability in large population studies. The purpose of this study was to investigate whether demographic, behavioral, and biological differences occur between those with IAD and valid accelerometry data (VAD) among adults using a representative sample of the civilian noninstitutionalized U.S. population. Methods: Ambulatory participants from NHANES (2003-2004) who were 20-85 years of age were included in the current study and wore an ActiGraph 7164 accelerometer for 7 days. A "valid person" was defined as those with 4 or more days of at …

Fatty Acid Fate In Determining Oxidation And Inflammation In Adipose Tissue, Emilio Patrick Mottillo

Wayne State University Dissertations

Adipose tissue (AT) is a critical regulator of energy balance through its ability to store or oxidize free fatty acids (FFAs). White adipose tissue (WAT) functions as an anabolic organ to sequester and release FAs, in contrast brown adipose tissue (BAT) is a catabolic organ that oxidizes FAs. However, a comprehensive understanding of the role that FFAs play in the function of WAT and BAT is needed. Here we demonstrate that intracellular FAs enhance the expression of inflammatory cytokines by β3-AR activation in adipocytes, in which the expression of PAI-1 is partly mediated by the de novo synthesis of ceramides/sphingolipids. …

Linking Environmental Toxicant Exposure To Diabetes Susceptibility, Jannifer Beth Tyrrell

Wayne State University Dissertations

An important and unresolved question in the environmental health field is whether exposure to common environmental toxicants, such as dioxin and heavy metals like Pb, increase the risk of developing diabetes, especially in combination with other common metabolic stressors such as obesity.

Previous studies suggested that dioxin exposure increased peripheral insulin resistance but did not appear to cause fasting hyperglycemia or elevated hepatic glucose output. In concordance with those findings we observed that dioxin treatment caused a strong suppression of the expression of the key hepatic gluconeogenic genes PEPCK and G6Pase. However, this suppression was not solely mediated by the …

The Effect Of Maternal Beliefs And Behavior On The Body Weight Status Of Preschool-Aged Children, Nicole Lynn Boucher

Wayne State University Dissertations

Early onset pediatric obesity has become a major health concern in the United States. Pediatric obesity can lead to childhood hypertension, type II diabetes, and orthopedic problems. Currently, in the United States one in seven low-income preschools are overweight or obese. One of the key contributing factors to early onset childhood obesity is how children are socialized to the eating and mealtime environment. Maternal feeding styles play an integral role in how children are socialized to the eating and mealtime environment.

The purpose of the this study was to determine the extent to which maternal beliefs and behavior regarding the …

An Investigation Of Perinatal Polychlorinated Biphenyl Exposure On Body Composition And Glucose Homeostasis, Cetewayo S. Rashid

Theses and Dissertations--Nutritional Sciences

Recent advancements have uncovered environmental contributions to obesity and diabetes etiology. In fact, perinatal malnutrition resulting in low birth weight (LBW) has been shown to correlate with later life obesity and impaired glucose tolerance in aged offspring. LBW can result from a myriad of developmental perturbations including macronutrient restriction, hypoxia, maternal stress and toxin exposure.

Polychlorinated biphenyls (PCBs) are ubiquitous environmental pollutants that bioaccumulate in the food chain resulting in dietary exposure in humans. Maternal and cord blood PCB levels are inversely associated with birth weight, and recent studies indicate that perinatal exposures to PCBs contribute to gender-specific obesity development …

Business Plan: Sports Facility In Rochester, Minnesota, Nikki Scherr

Master of Arts in Sport Management

This capstone project involves the construction of a new sports facility, The Sports Hut, located in Rochester, Minnesota. The mission of The Sports Hut organization is to get kids active at a young age, which allows the opportunity for athletes to thrive in their sport and passions, while providing a place to learn and grow in a healthy environment. Although obesity can be a very complex issue, Miller, Rosenbloom and Silverstein (2004) have discovered that obesity affects more than 30% of children and can be found commonly due to the environment and lifestyle in which they group up in. It …

Novel Insights Into The Function And Regulation Of Group X Secretory Phospholipase A2, Joseph D. Layne Jr

Theses and Dissertations--Nutritional Sciences

Group X secretory phospholipase A₂ (GX sPLA₂) hydrolyzes membrane phospholipids producing free fatty acids and lysophospholipids. Previous studies from our lab suggest that mice with targeted deletion of GX sPLA₂ (GX KO) have increased age-related weight gain due to an increase in overall adiposity. Paradoxically, this increased adiposity is associated with improved age-related glucose intolerance. GX KO mice also demonstrate a reduced inflammatory response to lipopolysaccharide injection. In vitro studies indicate this phenotype may be attributable to blunted macrophage mediated inflammatory responses. Given the role of macrophages in promoting adipose tissue (AT) inflammation and metabolic dysfunction …

Evaluating The Effectiveness Of An Internet-Based Behavioral Program For Increasing Physical Activity With And Without A Behavioral Coach, Diego Alejandro Valbuena

USF Tampa Graduate Theses and Dissertations

Obesity is a problem of vast social concern in the United States. One factor that has been linked to reduction in body fat and the health problems associated with obesity is increasing physical activity. Although in-person behavioral interventions have been shown effective at increasing physical activity, attention is now being placed on disseminating these interventions through the use of technology. Several internet-based interventions have been developed and are readily available. The purpose of this study was to evaluate "Fitbit," a web-based behavioral intervention for increasing physical activity and losing weight. Additionally, this study examined if the addition of contact from …

Participation In Immersion Weight Loss Treatment May Benefit, Not Harm, Young Adult Staff Members, Katherine Elizabeth Schaumberg

Legacy Theses & Dissertations (2009 - 2024)

American teens and young adults are at risk for developing pathological eating patterns, which can lead to eating disorders and obesity. Despite the success of weight management programs for obese individuals, some researchers caution that participation in an aggressive approach to weight management could promote the development of eating disorders. The current study evaluated the risks of following a weight management program for healthy young adults who served as staff members in immersion treatment of obesity over the course of a summer. Participants included Wellspring staff members (n = 108) along with a comparison group of young adults with similar …

Exposure To Persistent Organic Pollutants And Metabolic Diseases, Zafar Zayirovich Aminov

Legacy Theses & Dissertations (2009 - 2024)

Background: The metabolic syndrome (MetS) is a group of diseases that tend to occur together, including diabetes, hypertension, central obesity, cardiovascular disease and hyperlipidemia. Exposure to persistent organic pollutants (POPs) such as polychlorinated biphenyls (PCBs) and organochlorine pesticides (OCPs) have been associated with increased risk of development of several of the components of the MetS.

Using Geospatial Technologies To Characterize Relationships Between Travel Behavior, Food Availability, And Health, Warren J. Christian

Theses and Dissertations--Geography

Epidemic obesity in the U.S. has prompted exploration of causal factors related to the built environment. Recent research has noted statistical associations between the spatial accessibility of retail food sources, such as supermarkets, convenience stores, and restaurants, and individual characteristics such as weight, socioeconomic status, and race/ethnicity. These studies typically use residential proximity or neighborhood density to food sources as the measure of accessibility. Assessing food environments in this manner, however, is very limiting. Since most people travel outside of their neighborhood on a daily basis, the retail food sources available to individuals residing in the same area could vary …

The Effect Of Alpha-Cyclodextrin On Acute Blood Lipid And Glycemic Responses To A Fat Containg Meal, Evan Neil Fletcher

Wayne State University Theses

Obesity and hyperlipidemia have become major concerns in the United States over the past 30 years. Alpha-Cyclodextrin (á-CD), a naturally occurring soluble dietary fiber, has been shown to reduce dietary fat absorption and improve blood lipid levels in an animal model (mouse and rat) and in human studies. In the current double blind study, 34 healthy male and female participants were recruited to test if á-CD had any acute effect on blood lipid and glycemic responses to a fat containing meal. The participants received the á-CD on one occasion and a placebo the other to determine if there was any …

Obesity Is An Independent Predictor Of Breastfeeding Initiation When Socioeconomic Status Is Controlled For, Annemarie Bennett, Daniel Mccartney, John Kearney

Articles

Breastfeeding initiation rates vary across Europe, with rates as low as 56%(1) in Ireland and rates in excess of 90%(2) in the Nordic countries. A host of factors, including demographic, social, psychological and physical factors, influence the initiation, intensity and duration of breastfeeding. The extent to which modifiable factors influence breastfeeding initiation should be ascertained in order to prioritise support services for breastfeeding. Obesity is a known modifiable factor which inhibits breastfeeding initiation. This study aimed to determine the extent to which obesity inhibits breastfeeding initiation while controlling for socioeconomic status and other confounding factors. The Infant Cohort dataset from …

Early Onset Type 2 Diabetes And Associated Risk Factors, Grace Nyambura Kiraka

Master of Medicine in Clinical Pathology

Background: The incidence of type 2 diabetes in patients below the age of 40 (early onset diabetes) is markedly on the rise and has been linked increased prevalence of risk factors such as the metabolic syndrome and family history of diabetes. Objective: To determine the proportion of patients with type 2 diabetes at Aga Khan University Hospital Nairobi (AKUHN) who have early onset type 2 diabetes and the association of age of onset with risk factors (family history of diabetes, obesity, waist circumference, hypertension, low HDL cholesterol and hypertriglyceridaemia) in this group of patients. Methods: This was a cross sectional …

Obesity, Prediabetes, And Perceived Stress In Municipal Workers, Louise Camilleri O'Keefe

All ETDs from UAB

Obesity and diabetes are major contributors to morbidity and mortality in the United States. According to the American Public Health Association and Partnership for Prevention, obesity is growing faster than any other public health problem in the United States. The prevalence of diabetes has also increased significantly with an estimated 79 million Americans aged 20 years or older suffering from prediabetes. Few studies have examined the influence of perceived stress on obesity and prediabetes among working adults. Investigations are needed to examine factors that can contribute to higher health care costs for both employees and employers. The aims of this …

Tackling Overweight And Obesity: Does The Public Health Message Match The Science?, Katherine Hafekost, David Lawrence, Francis Mitrou, Therese O'Sullivan, Stephen R. Zubrick

Research outputs 2013

Background

Despite the increasing understanding of the mechanisms relating to weight loss and maintenance, there are currently no validated public health interventions that are able to achieve sustained long-term weight loss or to stem the increasing prevalence of obesity in the population. We aimed to examine the models of energy balance underpinning current research about weight-loss intervention from the field of public health, and to determine whether they are consistent with the model provided by basic science. EMBASE was searched for papers published in 2011 on weight-loss interventions. We extracted details of the population, nature of the intervention, and key …

Is Laparoscopic Gastric Banding An Effective Treatment For Obesity In Adolescents And Adults As Measured By Physical Function?, Shawna Mccormick

PCOM Physician Assistant Studies Student Scholarship

OBJECTIVE: The objective of this selective EBM review is to determine whether or not “Is laparoscopic gastric banding an effective treatment for obesity in adolescents and adults as measured by physical functioning?”

STUDY DESIGN: Review of all English language primary studies from 2009, 2010, and 2011.

DATA SOURCES: Two randomized control trials and one cohort study were found using PubMed, Medline, and OVID.

OUTCOMES MEASURED: There were multiple outcomes measured in the studies but the outcome of concern is quality of life post-operatively, specifically, physical functioning as measured by surveys including SF-36, Moorehead-Ardelt, BAROS, and CHQ CF-50. …

Social Cognitive Theory Vs. Social Comparison Theory: Examining The Relationship Between Social Influence And Weight Loss, Emily Grigg

Masters Theses

This qualitative study investigated the impact of social influence on weight loss, more specifically, the internal and external elements that effect response and success of those who are trying to lose weight. The research focused on three questions: (1) How great of an influence does self-efficacy have in weight loss success? (2) How great of an influence does social comparison have in weight loss success? (3) Which factor has the largest impact on weight loss: self-efficacy, peer efficacy, or positive social support, or negative social support? Data was collected by the researcher conducting semi-structured interviews. These interview were conducted with …

Emerging Modifiable Risk Factors For Cardiovascular Disease In Women: Obesity, Physical Activity, And Sedentary Behavior, Ann Smith Barnes

The Texas Heart Institute Journal

No abstract provided.

Significant Features Of Basal And Maximal Energy Expenditure Parameters In Obese Adults, Emi̇ne Uygur, Kağan Üçok, Abdurrahman Genç, Ümi̇t Şener, Ramazan Uygur, Ahmet Songur

Turkish Journal of Medical Sciences

To compare body composition, resting metabolic rate, and maximal aerobic capacity parameters in obese adults and healthy controls, as well as to investigate the associations among these parameters. Materials and methods: A total of 120 participants, 60 obese participants (30 male, 30 female) with body mass indexes (BMIs) over 30 kg/m^2 and 60 healthy controls (30 male, 30 female) with BMIs of 18-25 kg/m^2, were included in the study. BMI was calculated as body weight divided by the square of the height (kg/m^2). Body fat percentage, total body fat, and lean body mass were established with bioelectric impedance analysis. Resting …

Open Versus Laparoscopic Hiatal Hernia Repair., Terrence M. Fullum, Tolulope A. Oyetunji, Gezzer Ortega, Daniel D. Tran, Ian M. Woods, Olusola Obayomi-Davies, Orighomisan Pessu, Stephanie R. Downing, Edward E. Cornwell

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: The literature reports the efficacy of the laparoscopic approach to paraesophageal hiatal hernia repair. However, its adoption as the preferred surgical approach and the risks associated with paraesophageal hiatal hernia repair have not been reviewed in a large database.

METHOD: The Nationwide Inpatient Sample dataset was queried from 1998 to 2005 for patients who underwent repair of a complicated (the entire stomach moves into the chest cavity) versus uncomplicated (only the upper part of the stomach protrudes into the chest) paraesophageal hiatal hernia via the laparoscopic, open abdominal, or open thoracic approach. A multivariate analysis was performed controlling for …

Prevalence Of Overweight And Obesity In Classic Rett Syndrome., Kathrine Clova Grigsby

All ETDs from UAB

Introduction: Rett syndrome (RTT) is a genetic, neurodevelopmental disorder that displays high incidence of growth failure, variations in body composition, feeding/gastrointestinal complications, and undernutrition. The ongoing Rare Diseases Clinical Research Network (RDNCRN) Rett Syndrome Natural History Research Project has yielded observations regarding the less recognized occurrence of overnutrition in adult females with classic Rett syndrome. The purpose of this study was the determine the prevalence of overweight/obesity in children and young adults with classic Rett syndrome, the percent overweight and obese among adults with classic Rett syndrome, and to determine if the prevalence of overnutrition increases after the puberty years …

Apparent Change In Obesity-Mortality Associations: Methodological Issues In Survival Analyses With Censored Outcomes, Tapan Shirish Mehta

All ETDs from UAB

Analyses of the National Health and Nutrition Examination Survey (NHANES) have suggested that the mortality rate (MR) associated with obesity has decreased over calendar time. However, there has been conflicting evidence about the apparent change in the obesity-MR over calendar time. This dissertation investigates some of the empirical and methodological issues involved in assessing the longitudinal change in the obesity-mortality associations. In the first manuscript, Obesity and Mortality: Are the Risks Declining? Evidence from Multiple Prospective Studies in the U.S., a multiple longitudinal design is proposed and implemented to evaluate whether the obesity-mortality associations have declined over calendar time after …

Linking Obesity To Colorectal Cancer: Recent Insights Into Plausible Biological Mechanisms, Catherine Guffey

Theses and Dissertations

Obesity has emerged as a leading environmental risk factor for the development of CRC. However, the mechanisms underlying this relationship have not yet been fully explained. Recent literature has focused on 1) inflammatory processes, 2) adipokines, and 3) estrogen. Obesity-enhanced inflammation is largely orchestrated by increases in adipose tissue macrophages leading to the secretion of TNF-alpha, MCP-1, and IL-6, all of which are linked to CRC. Adiponectin is decreased with obesity and has been reported to be negatively associated with CRC, while leptin, which is increased, is positively associated with the disease. Estrogen has been shown to influence CRC, although …

Bmi At Diagnosis And Its Association With Markers Of Hiv Disease Progression And Cardiovascular Disease Risk., Kelly Deshon Johnson

Theses and Dissertations

Highly active antiretroviral treatment (HAART) has transformed the state of human immunodeficiency virus (HIV) from acute to chronic. As a result, the long-term effect of HAART has caused weight gain among HIV-infected individuals, leading to an increased prevalence of overweight and obesity. Increased Body Mass Index (BMI) has been associated with adverse health outcomes in non-HIV and HIV populations, yet among HIV-infected individuals, a higher BMI at diagnosis offers a slower progression from HIV to AIDS. Pre-HAART, studies reported that obese HIV-infected individuals have higher increases in CD4 count over time. However post-HAART, some report that overweight HIV-infected individuals with …