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Full-Text Articles in Medicine and Health Sciences

Portion Size Selection In Relation To Hemoglobin A1cs, Brian L. Dixon May 2014

Portion Size Selection In Relation To Hemoglobin A1cs, Brian L. Dixon

Undergraduate Honors Theses

Obesity has been recognized as an increasing issue within our country. Obesity contributes to many health related issues, including type 2 diabetes mellitus. Portion size is a factor that has generated clinical research interest. The aim of this study was to determine if there was a relationship between management of diabetes measured by hemoglobin A1c and portion size selection for type 2 diabetics. In this study, subjects selected portion sizes of four different foods. Data were compared to recent A1c levels. Due to the small sample size, nonparametric statistical analysis was used. The relationship of grain portion weight selection and …


Factors Associated With Physical Activity In Kindergarten Children, Carol Hammonds May 2014

Factors Associated With Physical Activity In Kindergarten Children, Carol Hammonds

Dissertations and Theses (Open Access)

Background: Reversing obesity is an urgent public health need for children: worldwide, in 2011 more than 40 million children under the age of five were either overweight or obese. Increasing intensity and duration of physical activity is a strategy to aid in preventing and reducing obesity. A minimum of 60 minutes per day of moderate to vigorous physical activity is recommended for children. School settings, such as full-day kindergarten, where 74% of children in the United States are enrolled, provide opportunities for population-based interventions to increase physical activity, yet little objective data exist on current levels of physical activity in …


Solving The Obesity Problem One Bite At A Time: A Review Of Interventions, Sally Catherine Davis May 2014

Solving The Obesity Problem One Bite At A Time: A Review Of Interventions, Sally Catherine Davis

Honors Theses

Resource limitations contribute to obesity in southern rural populations. An examination of published research provides evidence related to factors that lead to obesity and to related health consequences. Resource limitations in southern rural areas include a lack of access to healthy foods, a lack of safe areas to exercise or fitness equipment, and a lack of funding to promote the hiring of adequate numbers of healthcare workers to implement prevention programs and treat obesity related diseases. An investigation of obesity rates in Mississippi and Louisiana demonstrate that high rates of obesity exist. Through an exploration of published interventions in both …


Lean Body Mass May Explain Apparent Racial Differences In Carotid Intima-Media Thickness In Obese Children., Shahryar M. Chowdhury, Melissa H. Henshaw, Brad Friedman, J Philip Saul, Girish S. Shirali, Janet Carter, Bryana M. Levitan, Tom Hulsey May 2014

Lean Body Mass May Explain Apparent Racial Differences In Carotid Intima-Media Thickness In Obese Children., Shahryar M. Chowdhury, Melissa H. Henshaw, Brad Friedman, J Philip Saul, Girish S. Shirali, Janet Carter, Bryana M. Levitan, Tom Hulsey

Manuscripts, Articles, Book Chapters and Other Papers

Background: Racial differences in carotid intima-media thickness (cIMT) have been suggested to be associated with the disproportionally high prevalence of cardiovascular disease in black adults. The objective of this study was to evaluate the effects of cardiovascular risk factors on the racial differences seen in cIMT in obese children.

Methods: Obese subjects aged 4 to 21 years were recruited prospectively. Height, weight, blood pressure, fasting insulin, glucose, lipid panel, high-sensitivity C-reactive protein, and body composition by dual-energy x-ray absorptiometry were obtained. B-mode carotid imaging was analyzed by a single blinded physician.

Results: A total of 120 subjects (46 white, 74 …


Biomechanical And Ergonomic Impacts Of Handling In Obese Workers, Philippe Corbeil, André Plamondon, Normand Teasdale, Grant Handrigan, Jasmin Ten Have, Nancy Manzerolle May 2014

Biomechanical And Ergonomic Impacts Of Handling In Obese Workers, Philippe Corbeil, André Plamondon, Normand Teasdale, Grant Handrigan, Jasmin Ten Have, Nancy Manzerolle

Rapports de recherche scientifique

L’obésité est un problème émergent qui a des répercussions en santé et en sécurité du travail (SST). La prévalence de blessures musculo-squelettiques chez les individus obèses et les coûts indirects (non médicaux) sont plus élevés que ceux des travailleurs ayant un poids santé. Sachant qu’une hausse soutenue du taux d’obésité chez les travailleurs est observée au Canada, il est important de s’intéresser à la problématique de l’obésité liée au travail. Les risques de blessures au dos survenues au travail sont très élevés et la profession la plus touchée est celle de manutentionnaire. On connait peu l’effet de l’obésité sur les …


The Effects Of Obesity On Human Ambulation: A Lower Joint Analysis, Laura Gilbert Apr 2014

The Effects Of Obesity On Human Ambulation: A Lower Joint Analysis, Laura Gilbert

Senior Honors Theses

The effects of obesity on the body are complex and numerous especially when combining the effects on an already multi-faceted and multi-systems action such as human ambulation. This study summarizes a wide range of research performed, which investigated the effects of obesity on human ambulation. The effects are broken down into categories including osteoarthritis, replacement surgery, center of mass, stepping cycle, muscular activation, and specifics of the hip, knee and ankle joints as well as foot changes. The overwhelming majority of studies have found obesity to negatively impact ambulation by shifting center of mass (COM), increasing metabolic cost, decreasing cadence …


Women’S Understanding Of The Effects Of Obesity On Pregnancy, Rachel A. Daniel Apr 2014

Women’S Understanding Of The Effects Of Obesity On Pregnancy, Rachel A. Daniel

Senior Honors Theses

Obesity is a serious issue and is becoming a significant problem around the world. Obesity in general causes and complicates many health problems. As obesity increases in the population at large, the incidence of obesity in pregnancy continues to increase. Obesity during pregnancy has been linked in numerous studies to multiple complications, and the issues and risks have been clearly established. Also becoming pregnant or having multiple pregnancies increases the likelihood of developing obesity. Obese women of childbearing age many times do not even know these risks exist. There is a need to educate these women before they become pregnant, …


Childhood Obesity And Familial Hypercholesterolemia: Genetic Diseases That Contribute To Cardiovascular Disease, Alyssa Caudle Apr 2014

Childhood Obesity And Familial Hypercholesterolemia: Genetic Diseases That Contribute To Cardiovascular Disease, Alyssa Caudle

Senior Honors Theses

Childhood obesity occurs as the result of an imbalance between caloric intake and energy expenditure. Genetic risk factors for obesity have become an area of research due to its permanency. Mutated genes such as Fat Mass and Obesity Associated (FTO), Leptin (LEP), Leptin Receptor (LEPR), Melanocortin 4 Receptor (MC4R), Adiponectin C1Q and Collagen Domain Containing (ADIPOQ), Proprotein Convertase Subtilisin/Kexin Type 1 (PCSK1), and Peroxisome Proliferator-Activated Receptor Gamma (PPARG) all contribute to the development of childhood obesity. In the presence of high cholesterol caused by obesity, the genetic condition known as familial hypercholesterolemia is exacerbated. Familial hypercholesterolemia is caused by a …


Obesity Rates In Maine Exceed New England's Obesity Rate: A Look At Possible Contributing Factors, Susan Walker Apr 2014

Obesity Rates In Maine Exceed New England's Obesity Rate: A Look At Possible Contributing Factors, Susan Walker

Thinking Matters Symposium Archive

The purpose of this study was to explore adult obesity data to: Compare Maine’s rates with other New England states and explore differences in Maine counties by looking at known risk factors.


Obesity And Dining Out: An Exploration Of Dietary Trends In Urban Malaysia, Sylvia S. Lim Mar 2014

Obesity And Dining Out: An Exploration Of Dietary Trends In Urban Malaysia, Sylvia S. Lim

USF Tampa Graduate Theses and Dissertations

Economic growth has spurred rapid urbanization in Malaysia and triggered changes in diet, lifestyle, and disease trends. National studies show that a third of Malaysia's population is overweight/obese while household expenditures on dining out grow. In metropolitan Kuala Lumpur (KL), residents navigate concepts of nutrition, body weight, and health as they dine out. Using the biocultural framework, this study examined links between body weight, diet, income, street food consumption, and nutritional knowledge through the perspectives of consumers and vendors. Altogether, 77 participants were recruited for this three-phase research. In the first phase, a survey was administered to 60 participants recruited …


Evaluation Of The Interest In Development And Availability Of The Resting Metabolic Rate Test As A Routine Healthcare Standard, Seth Wayne Parrish Mar 2014

Evaluation Of The Interest In Development And Availability Of The Resting Metabolic Rate Test As A Routine Healthcare Standard, Seth Wayne Parrish

USF Tampa Graduate Theses and Dissertations

Introduction: A growing worldwide pandemic exists today that has large implications for the future of healthcare among the nations. Obesity is a growing disease that has multiple

implications for morbidity and mortality including cardiovascular disease, stroke and diabetes. The obese and overweight population plagues nearly 46% of the world's population, and likely is

preventable. We wanted to examine what role metabolic testing could play in prevention.

Methods: A cross-sectional study composed of a 52-question Likert-based scale survey was constructed and distributed to healthcare providers. We hypothesized that there would be a

generally accepted interest in establishing routine metabolic rate testing …


Determinants Of Physical Activity In Arab American Children, Wearn Alkhatib Phd Mar 2014

Determinants Of Physical Activity In Arab American Children, Wearn Alkhatib Phd

Dissertations

Physical activity is an integral part of preventing and managing childhood and adolescent obesity. Lack of regular physical activity has negative impact on physical and psychosocial health. Arab Americans (AAs), one of the most rapidly growing minorities in United States, tend to have a high prevalence of obesity and low participation in physical activity. The purpose of this study was to describe determinants of physical activity, including self-efficacy, social support, physical environment, and selected demographics among AA children in Southern California. A descriptive correlational study using a cross sectional design was conducted. Self-administered questionnaires were completed by children (N=206) recruited …


Hpv Vaccine Status And Bmi Correlation, Ezhilarasi Manickavasagam, Hongying Dai, Joan R. Griffith Feb 2014

Hpv Vaccine Status And Bmi Correlation, Ezhilarasi Manickavasagam, Hongying Dai, Joan R. Griffith

Manuscripts, Articles, Book Chapters and Other Papers

Obese women are at increased risk of death from cervical cancer compared to non-obese women. Yet, research indicates a lower rate of cervical cancer screening among obese women, especially severely obese white women. Cited reasons for delaying screening include embarrassment, perceived weight stigma, lack of appropriately sized examination equipment and poor patient-provider communication. Parental acceptance of the Human Papillomavirus (HPV) vaccine for overweight adolescent females may decrease the incidence of cervical cancer among obese women in later years. This study seeks to determine the Human Papillomavirus (HPV) vaccination status of females, ages 11 to 21 years, in a university-based pediatric …


Epidemiology News, Georgia Southern University Feb 2014

Epidemiology News, Georgia Southern University

Biostatistics, Epidemiology & Environmental Health Sciences: News & Publications (2011-2018)

  • Perceptions of Child Overweight and Obesity


Health Policy & Management News, Georgia Southern University Feb 2014

Health Policy & Management News, Georgia Southern University

Health Policy & Community Health: News & Publications (2011-2018)

  • Perceptions of Child Overweight and Obesity


“Obesity Is A Disease”: Examining The Self-Regulatory Impact Of This Public-Health Message, Crystal L. Hoyt, Jeni L. Burnette, Lisa Auster-Gussman Jan 2014

“Obesity Is A Disease”: Examining The Self-Regulatory Impact Of This Public-Health Message, Crystal L. Hoyt, Jeni L. Burnette, Lisa Auster-Gussman

Jepson School of Leadership Studies articles, book chapters and other publications

In the current work, we examined the impact of the American Medical Association’s recent classification of obesity as a disease on weight-management processes. Across three experimental studies, we highlighted the potential hidden costs associated with labeling obesity as a disease, showing that this message, presented in an actual New York Times article, undermined beneficial weight-loss self-regulatory processes. A disease-based, relative to an information-based, weight-management message weakened the importance placed on health-focused dieting and reduced concerns about weight among obese individuals—the very people whom such public-health messages are targeting. Further, the decreased concern about weight predicted higher-calorie food choices. In addition, …


Farmers' Market Use Is Associated With Fruit And Vegetable Consumption In Diverse Southern Rural Communities, Stephanie B. Jilcott Pitts, Alison A. Gustafson, Qiang Wu, Mariel Leah Mayo, Rachel K. Ward, Jared T. Mcguirt, Ann P. Rafferty, Mandee F. Lancaster, Kelly R. Evenson, Thomas C. Keyserling, Alice S. Ammerman Jan 2014

Farmers' Market Use Is Associated With Fruit And Vegetable Consumption In Diverse Southern Rural Communities, Stephanie B. Jilcott Pitts, Alison A. Gustafson, Qiang Wu, Mariel Leah Mayo, Rachel K. Ward, Jared T. Mcguirt, Ann P. Rafferty, Mandee F. Lancaster, Kelly R. Evenson, Thomas C. Keyserling, Alice S. Ammerman

Dietetics and Human Nutrition Faculty Publications

Background

While farmers’ markets are a potential strategy to increase access to fruits and vegetables in rural areas, more information is needed regarding use of farmers’ markets among rural residents. Thus, this study’s purpose was to examine (1) socio-demographic characteristics of participants; (2) barriers and facilitators to farmers’ market shopping in southern rural communities; and (3) associations between farmers’ market use with fruit and vegetable consumption and body mass index (BMI).

Methods

Cross-sectional surveys were conducted with a purposive sample of farmers’ market customers and a representative sample of primary household food shoppers in eastern North Carolina (NC) and the …


Metabolic Factor: A New Clinical Tool In Obesity Diagnosis And Weight Management, Brandon Davis, Joseph Indelicato, Nicholas Kuiper Jan 2014

Metabolic Factor: A New Clinical Tool In Obesity Diagnosis And Weight Management, Brandon Davis, Joseph Indelicato, Nicholas Kuiper

The School of Health Sciences Publications and Research

Obtaining resting metabolic rates (RMR) via indirect calorimetry is a critical component of weight management that is used to calculate a new concept, metabolic factor. This calculation allows for the standardized expression of RMR to make it possible to compare metabolism between people and over time. This study found an inverse relationship between weight and metabolic factor, statistically significant, r = -­‐.63, p < 0.001, effect size = .46, suggesting that people who weigh more tend to have lower metabolic factors. Furthermore, statistically significant differences were found in the metabolic factors between people who were normal weight, overweight, and obese, p < 0.001. There was also an inverse relationship between metabolic factor and age, r = -­‐0.21, p < .05, effect size = .03, suggesting that age has a small but significant effect of metabolic factor. This variable has the potential to play a key role in treatment planning as it can be used to set realistic weight goals, determine caloric needs for a given weight, and to make decisions as to surgical intervention. More importantly, metabolic factor can be a key instrument in clinical work used to educate people regarding unique differences in metabolism to lower prejudice against the obese and to reduce the devastating shame that often accompanies weight issues.


Ethical Dilemmas Posed In The Care Of Obese Patients In The Emergency Department, Arvind Venkat, Gregory Luke Larkin Jan 2014

Ethical Dilemmas Posed In The Care Of Obese Patients In The Emergency Department, Arvind Venkat, Gregory Luke Larkin

Journal of Health Ethics

The rising prevalence of obesity represents a health care crisis. As the gateway to the health care system, the emergency department is the clinical setting where the difficulties posed by the care of obese patients are heightened. These difficulties include the increasing burden of obesity-related illnesses, the challenges posed in diagnostic evaluation and treatment and the known barriers to access to care seen in this patient population. The limitations posed by obesity on care in the emergency department, the one guaranteed access point for medical treatment, creates a series of ethical dilemmas for emergency physicians and the facilities in which …


The Effectiveness Of Telemedicine For Weight Management In The Move! Program, April D. Ahrendt, Kendra K. Kattelmann, Thomas S. Rector, David A Maddox Jan 2014

The Effectiveness Of Telemedicine For Weight Management In The Move! Program, April D. Ahrendt, Kendra K. Kattelmann, Thomas S. Rector, David A Maddox

Health and Nutritional Sciences Faculty Publications

PURPOSE: To examine the effectiveness of videoconferencing technology for delivering comprehensive weight management treatment.
METHODS: This retrospective cohort study was conducted by extraction of data from medical records for the years 2008-2010. The treatment included a series of 12 weekly MOVE!® classes delivered using videoconferencing. Data were extracted from the time of baseline weight to 1 year after baseline weight for the MOVE! participants (n = 60) and from a concurrent control group (n = 60) that did not participate in MOVE! treatment.
FINDINGS: Results indicated that the MOVE! group lost weight while the control group gained weight, resulting in …


Associations Between U.S. Adult Obesity And State And County Economic Conditions In The Recession, Qi Zhang, Rajan Lamichhane, Youfa Wang Jan 2014

Associations Between U.S. Adult Obesity And State And County Economic Conditions In The Recession, Qi Zhang, Rajan Lamichhane, Youfa Wang

Community & Environmental Health Faculty Publications

This study examines the association between state and county unemployment rates and individuals' body weight status during the latest recession in the U.S. We used the U.S. Behavioral Risk Factor Surveillance System (BRFSS) data in 2007, 2009 and 2011, which were collected from 722,692 American adults aged 18 or older. Overweight and obesity were defined as body mass index (BMI) ≥25, and ≥30, respectively. Multivariate linear and logistic regressions were applied to assess the association between BMI, risks of overweight and obesity, and state and county unemployment rates. State unemployment rates were negatively associated with individual BMI across years, while …


Influence Of Diet And Obesity On Copd Development And Outcomes, Corrine K. Hanson, Erica P. Rutten, Emiel F.M. Wouters, Stephen I. Rennard Jan 2014

Influence Of Diet And Obesity On Copd Development And Outcomes, Corrine K. Hanson, Erica P. Rutten, Emiel F.M. Wouters, Stephen I. Rennard

Journal Articles: Pulmonary & Critical Care Med

The global increase in the prevalence and incidence of obesity has called serious attention to this issue as a major public health concern. Obesity is associated with many chronic diseases, including cardiovascular disease and diabetes, and recently the role of overweight and obesity in lung disease has received new interest. Independently of obesity, diet also plays a role as a risk factor for many chronic diseases, and evidence is accumulating to support a role for diet in the prevention and management of several lung diseases. Chronic obstructive lung disease is the third-leading cause of death globally, and both obesity and …


Low Birth Weight Male Guinea Pig Offspring Display Increased Visceral Adiposity In Early Adulthood., Ousseynou Sarr, Jennifer A Thompson, Lin Zhao, Ting-Yim Lee, Timothy Regnault Jan 2014

Low Birth Weight Male Guinea Pig Offspring Display Increased Visceral Adiposity In Early Adulthood., Ousseynou Sarr, Jennifer A Thompson, Lin Zhao, Ting-Yim Lee, Timothy Regnault

Paediatrics Publications

Uteroplacental insufficiency (UPI)-induced intrauterine growth restriction (IUGR) predisposes individuals to adult visceral obesity. We postulated that low birth weight (LBW) offspring, from UPI-induced IUGR pregnancies, would display a visceral adipose lipogenic molecular signature involving altered gene expression, phosphorylation status of proteins of the lipid synthesis pathway and microRNA (miR) expression profile, occurring in association with increased visceral adiposity. Normal birth weight (NBW) and LBW (obtained by uterine artery ablation) male guinea pig pups were fed a control diet from weaning to 145 days and sacrificed. Despite being lighter at birth, LBW pups displayed body weights similar to NBW offspring at …


Limiting Liberty To Prevent Obesity: Justifiability Of Strong Hard Paternalism In Public Health Regulation, Thaddeus Mason Pope Jan 2014

Limiting Liberty To Prevent Obesity: Justifiability Of Strong Hard Paternalism In Public Health Regulation, Thaddeus Mason Pope

Faculty Scholarship

Because of the largely self-regarding nature of obesity, many current and proposed public health regulatory measures are paternalistic. That is, these measures interfere with a person’s liberty with the primary goal of improving that person’s own welfare.

Paternalistic public health measures may be effective in reducing obesity. They may even be the only sufficiently effective type of regulation. But many commentators argue that paternalistic public health measures are not politically viable enough to get enacted. After all, paternalism is repugnant in our individualistic culture. It is "wrong" for the government to limit our liberty for our own good.

In this …


Weight-Loss Interventions Performed To Reduce The Risk Of Obesity-Related Complications, Victoria Stephanie Stewart Jan 2014

Weight-Loss Interventions Performed To Reduce The Risk Of Obesity-Related Complications, Victoria Stephanie Stewart

Walden Dissertations and Doctoral Studies

The management of obesity before a woman conceives is one of the most effective efforts a woman can take in decreasing her risk of obesity-related complications during pregnancy. Evidence supports the idea that maternal obesity influences maternal and fetal outcomes, leading to maternal and fetal morbidities. Physicians acknowledge the importance of screening women for obesity, but many do not refer patients for weight-loss therapy. In this study, the health belief model was used to explore the associations between participants' obesity risk of complications during pregnancy, the number of weight-loss interventions they attempted to implement prior to pregnancy, and how they …


Impact Of Positive And Negative Health Behaviors On Female Mice And/Or Their Offspring, Kristen M. Platt Jan 2014

Impact Of Positive And Negative Health Behaviors On Female Mice And/Or Their Offspring, Kristen M. Platt

Theses and Dissertations--Pharmacology and Nutritional Sciences

Obesity is an ever-growing concern in the developed world that carries with it a plethora of health issues. For example, obesity increases an individual’s risk for Type 2 Diabetes and cardiovascular disease. Pregnancy is a vital time for a woman to maintain optimal health, both for her own benefit as well as that of her offspring, and yet almost half of women in the United States who are of age to bear children are overweight or obese. In mice, we found that offspring born to dams fed a high fat diet did not have impaired glucose tolerance, contrary to our …


A Description Of Snack Foods In Select Ohio Schools: A Baseline Prior To Usda New Competitive Food Guidelines, Chukwudubem C. Obianagha Jan 2014

A Description Of Snack Foods In Select Ohio Schools: A Baseline Prior To Usda New Competitive Food Guidelines, Chukwudubem C. Obianagha

Master of Public Health Program Student Publications

Background: The proliferation of snack foods in school lunch programs has necessitated the USDA to regulate its consumption by implementing policies regarding its use. The competitive food guidelines were enacted in June 2013 through the Healthy, Hunger-Free Kids Act. This required development of federal nutritional guidelines snack foods had to meet in order to be considered a competitive food and thus sold in school lunchrooms.

Objectives: The purpose of this study is to describe the current snack food offerings in select Ohio high schools, and to determine how these snack foods affect the consumption of healthier free and reduced meal …


Preventing Childhood Obesity: A Mixed Methods Study Into The Perceptions Of African Americans In A Rural Community, Dayna S. Alexander Jan 2014

Preventing Childhood Obesity: A Mixed Methods Study Into The Perceptions Of African Americans In A Rural Community, Dayna S. Alexander

College of Graduate Studies: Theses & Dissertations

Preventing childhood obesity is a global priority due to adverse health risks and financial burdens. With childhood obesity rates stabilizing it is difficult to determine which factors alone (i.e., genetic, environmental, behavioral, or demographic) increase susceptibility to childhood obesity. Parents influence childhood obesity risk factors through their parenting styles and behaviors. Social behavioral theories and public health evidence demonstrate including parents in childhood obesity efforts could assist in reducing childhood obesity rates. The objective of this study was to assess perceptions of childhood obesity among African Americans with children enrolled in a rural elementary school in the Deep South. The …


Obesity, Food Insecurity And The Impact On Perceptions And Behaviors Toward Dietary Nutrition In Low Income Women In Georgia, Amanda Lowe Jan 2014

Obesity, Food Insecurity And The Impact On Perceptions And Behaviors Toward Dietary Nutrition In Low Income Women In Georgia, Amanda Lowe

College of Graduate Studies: Theses & Dissertations

The purpose of this study was to explore the paradoxical relationship between obesity and food insecurity and the subsequent impact of this relationship on perceptions and behaviors towards diet and nutrition among low-income women in Georgia. Specifically, this study sought to investigate whether factors such as poverty, education, socio-economic status, and participation in food assistance programs influence obesity outcomes among low-income women in Georgia. A sequential exploratory mixed-method research design was conducted for this study. Using qualitative and quantitative measures, the study employed key informant interviews with 16 administrators and staff members from the Women, Infant and Children (WIC) program …


The Role Of Angiotensinogen In Atherosclerosis And Obesity, Congqing Wu Jan 2014

The Role Of Angiotensinogen In Atherosclerosis And Obesity, Congqing Wu

Theses and Dissertations--Nutritional Sciences

Angiotensinogen is the only known precursor in the renin-angiotensin system, a hormonal system best known as an essential regulator of blood pressure and fluid homeostasis. Angiotensinogen is sequentially cleaved by renin and angiotensin- converting enzyme to generate angiotensin II. As the major effector peptide, angiotensin II mainly function through angiotensin type 1 receptor.

Angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, and more recently renin inhibitors are widely known as the 3 classic renin-angiotensin system inhibitory drugs against hypertension and atherosclerosis. Here, we developed an array of regents to explore the effects of angiotensinogen inhibition. First, we demonstrated that genetic deficiency of …