Medicine and Health Sciences Commons^™

Cohort Of Birth Modifies The Association Between Fto Genotype And Bmi, James Niels Rosenquist, Steven F. Lehrer, A. James O'Malley, Alan M. Zaslavsky, Jordan W. Smoller, Nicholas A. Christakis

Dartmouth Scholarship

A substantial body of research has explored the relative roles of genetic and environmental factors on phenotype expression in humans. Recent research has also sought to identify gene-environment (or g-by-e) interactions, with mixed success. One potential reason for these mixed results may relate to the fact that genetic effects might be modified by changes in the environment over time. For example, the noted rise of obesity in the United States in the latter part of the 20th century might reflect an interaction between genetic variation and changing environmental conditions that together affect the penetrance of genetic influences. To evaluate this …

The Mechanisms Of Weight Gain In Sleep-Deprived Individuals, Chaya Rosen

The Science Journal of the Lander College of Arts and Sciences

The obese population in America has grown during the last century. During these years as well, American’s have been sleeping less. Cross sectional studies show that there is a correlation of the two factors, and indeed find a greater number of overweight individuals amongst the sleep-deprived population. Though they are unclear, studies attempt to establish possible mechanisms through which weight gain occurs. Results of studies show that sleep deprivation may influence leptin and ghrelin levels, which can cause hunger, and excessive caloric intake. Sleep-deprived individuals also have an increased opportunity to eat during the wakeful nighttime hours. In the sleep-restricted …

Spatiotemporal Discordance In Five Common Measures Of Rurality For Us Counties And Applications For Health Disparities Research In Older Adults, Steven A. Cohen, Lauren Kelley, Alison E. Bell

Family Medicine and Population Health Publications

Introduction

Rural populations face numerous barriers to health, including poorer health care infrastructure, access to care, and other sociodemographic factors largely associated with rurality. Multiple measures of rurality used in the biomedical and public health literature can help assess rural–urban health disparities and may impact the observed associations between rurality and health. Furthermore, understanding what makes a place truly “rural” versus “urban” may vary from region to region in the US.

Purpose

The objectives of this study are to compare and contrast five common measures of rurality and determine how well-correlated these measures are at the national, regional, and divisional …

How Does The Brain Implement Adaptive Decision Making To Eat?, Valérie Compan, B. Timothy Walsh, Walter Kaye, Allan Geliebter

Lander College of Arts and Sciences Publications and Research

Adaptive decision making to eat is crucial for survival, but in anorexia nervosa, the brain persistently supports reduced food intake despite a growing need for energy. How the brain persists in reducing food intake, sometimes even to the point of death and despite the evolution of multiple mechanisms to ensure survival by governing adaptive eating behaviors, remains mysterious. Neural substrates belong to the reward-habit system, which could differ among the eating disorders. The present review provides an overview of neural circuitry of restrictive food choice, binge eating, and the contribution of specific serotonin receptors. One possibility is that restrictive food …

Neuroimaging And Neuromodulation Approaches To Study Eating Behavior And Prevent And Treat Eating Disorders And Obesity, D. Val-Laillet, E. Aarts, B. Weber, M. Ferrari, V. Quaresima, L. E. Stoeckel, M. Alonso-Alonso, M. Audette, C. H. Malbert, E. Stice

Computational Modeling & Simulation Engineering Faculty Publications

Functional, molecular and genetic neuroimaging has highlighted the existence of brain anomalies and neural vulnerability factors related to obesity and eating disorders such as binge eating or anorexia nervosa. In particular, decreased basal metabolism in the prefrontal cortex and striatum as well as dopaminergic alterations have been described in obese subjects, in parallel with increased activation of reward brain areas in response to palatable food cues. Elevated reward region responsivity may trigger food craving and predict future weight gain. This opens the way to prevention studies using functional and molecular neuroimaging to perform early diagnostics and to phenotype subjects at …

What The Obesity Prevention Field Can Learn From The Gay Marriage Movement, Sergio Costa, Emily Ferris, Terry T-K Huang

Publications and Research

In the US, two-thirds of adults and one-third of children continue to be affected by overweight or obesity despite two decades and billions of dollars' spent in public health efforts. In the last decade, public health has stepped up its call for greater emphasis on environmental and policy interventions, including active designs in urban planning and restrictions on food marketing to children, to incentivize healthy behaviors and disincentivize less healthy ones. However, there has been little success in policy change to prevent obesity. Voters in Berkeley, CA recently passed a one-cent-per-ounce soda tax, but a similar measure was defeated by …

Tolerability Of Induction Chemotherapy Dosing Practices In Acute Myeloid Leukemia Patients, Kaylene M. Peric, David J. Reeves

Scholarship and Professional Work – COPHS

For patients with high body surface areas (BSA), differing chemotherapy dosing strategies have been utilized in attempts to reduce toxicity. In a retrospective evaluation, we compared the effects of chemotherapy dosing in acute myeloid leukemia patients with high BSA (>2 m²) who received capped doses (n = 12) to those who received uncapped doses (n = 24), and to patients with BSA ≤ 2 m² (n = 42). There were no statistically significant differences among groups (BSA ≤ 2 m², BSA > 2 m² capped, and BSA > 2 m² uncapped) …

The Effects Of Barriers Toward Fighting Childhood Obesity Within Head Start, Vanessa Chaney

Walden Dissertations and Doctoral Studies

Childhood obesity is associated with significant morbidity and mortality and poses a health care burden. Child care facilities serve at the forefront in fighting childhood obesity among preschoolers. Since 2009, a significant shift has occurred in studying child care settings among children aged 3-5 in North Carolina and South Carolina in response to the rising rates of obesity in this population. Some of the hypothesized determinants of childhood obesity among preschoolers in North Carolina and South Carolina are outdoor activity, staff behavior, center's size and location. The purpose of this study was to investigate if significant relationships exist between childhood …

Prevalence Of Obesity And Overweight, Its Clinical Markers And Associated Factors In A High Risk South-Asian Population, Faridah Amin, Syeda Sadia Fatima, Najmul Islam, Anwar H. Gilani

Department of Biological & Biomedical Sciences

Background: Obesity is a global epidemic, which is a risk factor for cardiovascular diseases and metabolic abnormalities. It is measured by body mass index (BMI), waist circumference (WC), waist-hip ratio (WHR), body fat (BF) distribution and abdominal fat mass, each having its own merits and limitations. Variability in body composition between ethnic groups in South-Asians is significant and may not be truly reflected by BMI alone, which may result in misclassification. This study therefore, aims to determine the frequency of obesity, body fat composition and distribution, in a high risk population of an urban slum of Karachi, Pakistan. This survey …

Health At Every Size Program Intervention Versus Traditional Weight Loss Intervention: Impact On Diet And Physical Activity, Brooke Noble

Electronic Theses and Dissertations

Backround. A shift from a weight-focus to a health focus -Health At Every Size (HAES)-has been suggested. Yet, little research has compared the impact of this approach to a traditional weight loss program on diet, while physical activity, anthropometric and health indicators have been mixed. Objective. This study evaluated diet, physical activity, anthropometric measurements, blood pressure, blood sugar and cholesterol in participants in these two interventions. It was hypothesized that the HAES group would consume a more nutrient dense diet, more whole foods, higher fiber and lower sodium, while the traditional group would consume lower calories, fat and fiber …

Weight Management Counseling And Obesity Severity In Children With Special Health Care Needs, Adeola Sonaike

Walden Dissertations and Doctoral Studies

Epidemiologic surveillance indicates an increased susceptibility to obesity among children with special health care needs (SHCN) in comparison to children without. The present study investigated this disparity in weight severity between both groups, with a focus on the provision of obesity management counseling by physicians. This study consisted of a retrospective medical record review that acknowledged the effect of patient-provider interactions on health behaviors and risk perceptions. An independent sample t test compared the incidence of clinician-initiated obesity management counseling received by children with SHCN to that which was received by children without SHCN. This t test revealed a statistically …

Menthol Cigarette Smoking And Obesity In Young Adult Daily Smokers In Hawaii, Alyssa Marie M. Antonio, Pebbles Fagan, Faith D. Hamamura, Ian Joseph N. Lagua, Jenny Liu, Devin J. Park, Pallav Pokhrel, Thaddeus A. Herzog, Ian Pagano, Kevin Cassel, Angela Sy, Dorothy Jorgensen, Tania Lynch, Crissy Kawamoto, Carol J. Boushey, Adrian Franke, Mark S. Clanton, Eric T. Moolchan, Linda A. Alexander

Health, Behavior & Society Faculty Publications

This study investigates 1) the relationship between menthol cigarette smoking and obesity and 2) the association of body mass index with the nicotine metabolite ratio among menthol and non-menthol daily smokers aged 18–35 (n = 175). A brief survey on smoking and measures of height and weight, carbon monoxide, and saliva samples were collected from participants from May to December 2013 in Honolulu, Hawaii. Multiple regression was used to estimate differences in body mass index among menthol and non-menthol smokers and the association of menthol smoking with obesity. We calculated the log of the nicotine metabolite ratio to examine differences …

Intrinsic Disorder In Biomarkers Of Insulin Resistance, Hypoadiponectinemia, And Endothelial Dysfunction Among The Type 2 Diabetic Patients, Osama H. Jiffri, Fadwa M. Al-Sharif, Essam H. Jiffri, Vladimir N. Uversky

Molecular Medicine Faculty Publications

Type 2 diabetes mellitus (T2DM) is a chronic and progressive disease that is strongly associated with the all-cause and cardiovascular mortality. The present study aimed to analyze the abundance and functionality of intrinsically disordered regions in several biomarkers of insulin resistance, adiponectin, and endothelial dysfunction found in the T2DM patients. In fact, in comparison to controls, obese T2DM patients are known to have significantly higher levels of inter-cellular adhesion molecule (iCAM-1), vascular cell adhesion molecule (vCAM-1), and E-selectin, whereas their adiponectin levels are relatively low. Bioinformatics analysis revealed that these selected biomarkers (iCAM-1, vCAM-1, E-selectin, and adiponectin) are characterized by …

Intrinsic Disorder In Biomarkers Of Insulin Resistance, Hypoadiponectinemia, And Endothelial Dysfunction Among The Type 2 Diabetic Patients, Osama H. Jiffri, Fadwa M. Al-Sharif, Essam H. Jiffri, Vladimir N. Uversky

Molecular Medicine Faculty Publications

Type 2 diabetes mellitus (T2DM) is a chronic and progressive disease that is strongly associated with the all-cause and cardiovascular mortality. The present study aimed to analyze the abundance and functionality of intrinsically disordered regions in several biomarkers of insulin resistance, adiponectin, and endothelial dysfunction found in the T2DM patients. In fact, in comparison to controls, obese T2DM patients are known to have significantly higher levels of inter-cellular adhesion molecule (iCAM-1), vascular cell adhesion molecule (vCAM-1), and E-selectin, whereas their adiponectin levels are relatively low. Bioinformatics analysis revealed that these selected biomarkers (iCAM-1, vCAM-1, E-selectin, and adiponectin) are characterized by …

The Effect Of Bmi On Oxygen Saturation At Rest And During Mild Walking, Jerrold S. Petrofsky, Michael S. Laymon, Iman Akef Khowailed, Stacy Fisher, Andrew Mills

College of Health & Human Services (TUN) Publications and Research

Eighty one subjects were examined for the relationship between BMI, body fat, arterial oxygen saturation and arterial PO2 with the subjects at rest and after 5 minutes of walking on a treadmill ergometer at 3 mph at a 3% grade. They had BMIs between 19 and 50. All subjects were free of cardiovascular disease and had normal blood pressure making it safe for them to participate in mild exercise. They were all able to walk for at least 10 minutes without cardiovascular complications and were not taking any medications that altered the autonomic nervous system. The age was between 22 …

Regulation Of Ghrelin: A Possible Treatment Option For Obesity And Diabetes, Sarah Picciotto

The Science Journal of the Lander College of Arts and Sciences

Obesity is a mounting problem in America today. One major concern about obesity is that it is a risk factor for type 2 diabetes, a disease that impairs insulin sensitivity and secretion. This interferes with blood glucose levels and can cause hyperglycemia, which is when there is too much circulating glucose in the blood. Ghrelin, an amino acid peptide responsible for appetite stimulation and energy balance, plays a direct role in insulin secretion and glucose metabolism. In many experiments, elevated ghrelin levels are associated with decreased insulin secretion from pancreatic islet cells. Although ghrelin concentration is decreased in obese individuals …

Prevalence Of Hypertension And Its Association With Obesity Among Schoolchildren Aged 6-15 Living In Sakarya Province In Turkey, Fati̇h Muhammed Önsüz, Fi̇gen Demi̇r

Turkish Journal of Medical Sciences

Background/aim: Childhood hypertension and its association with obesity are becoming important issues worldwide. The prevalence of hypertension and obesity are growing in both developed and developing countries. This paper aimed to determine the prevalence of hypertension among school-aged children in Sakarya (western part of Turkey) and to determine whether or not obesity is associated with hypertension. Materials and methods: Twelve schools were randomly selected from an area in the center of the Sakarya. A total of 2166 students participated in the study. The students were visited at school, and their weights, heights, and blood pressures were measured. The World Health …

Correlation Between Body Mass Index And Semen Quality In Male Infertility Patients, Tang Wen-Hao, Zhuang Xin-Jie, Ma Lu-Lin, Qiao Jie, Hong Kai, Zhao Lian-Ming, Liu De-Feng, Mao Jia-Ming, Zhang Hong-Liang, Zhou Shan-Jie, Jiang Hui

Turkish Journal of Medical Sciences

Background/aim: The question of whether body mass index (BMI) affects semen quality and male fertility is controversial. The purpose of this research was to determine whether there is a correlation between BMI and semen analysis parameters. Materials and methods: A total of 617 male infertility patients were recruited and separated into 3 groups according to BMI values as follows: normal weight group (n = 334), overweight group (n = 220), and obese group (n = 63). Height and weight were measured and a routine semen analysis was performed for all patients. Results: Significant differences existed in BMI, age, and sperm …

Evaluation Of The Move Program On Weight Loss Among Veterans, William Justin Allen

DNP Projects

The most current estimations from the CDC classify more than one third of the American population as obese (2011). This epidemic continues to contribute to a number of chronic diseases across the country including diabetes and heart disease, both associated with high morbidity and mortality (NHLBI, 1998). Billions of dollars are spent annually on obesity and obesity related conditions.

Perhaps this is what led the U.S. Department of Health and Human Services (HHS) to select Nutrition, Physical Activity, and Obesity as a Leading Health Indicator in Healthy People 2020. The updated NHLBI guidelines, based on clinical evidence, offer a blueprint …

An Exploratory Study Of Infant Physical Activity In Relation To Obesity, Danae M. Dinkel, Jung-Min Lee, Kailey Snyder, Anastasia Kyvelidou

Research Presentations

Historically, society has thought that infants (0 to 1 year of age) are “active enough” and not in need of efforts to promote physical activity (PA). However, approximately 10% of infants in the U.S. are obese and research has shown low PA is one of the risk factors for obesity in toddlers. Little research has been done to systematically compare PA levels between normal weight infants and obese/overweight infants in the first year of life. PURPOSE: The purpose of this study was to determine the level of PA in normal weight and overweight infants. METHODS: Twenty-one normal weight …

Regulation Of Pancreatic Β-Cell Function By The Renin-Angiotensin System In Type 2 Diabetes, Robin C. Shoemaker

Theses and Dissertations--Pharmacology and Nutritional Sciences

Diet-induced obesity promotes type 2 diabetes (T2D). Drugs that inhibit the renin-angiotensin system (RAS) have been demonstrated in clinical trials to decrease the onset of T2D. Previously, we demonstrated that mice made obese from chronic consumption of a high-fat (HF) diet have marked elevations in systemic concentrations of angiotensin II (AngII). Pancreatic islets have been reported to possess components of the renin-angiotensin system (RAS), including angiotensin type 1a receptors (AT1aR), the primary receptor for AngII, and angiotensin converting-enzyme 2 (ACE2), which negatively regulates the RAS by catabolizing AngII to angiotensin-(1-7) (Ang-(1-7)). These two opposing proteins have been implicated in the …

Weight Management Of Women Of Childbearing Age, Marcia Hagen

Walden Dissertations and Doctoral Studies

Black River Memorial Hospital identified obesity as a priority health concern in its rural service area; this concern was in line with the county's needs assessment. It was identified that women of childbearing age affect the lifestyle and health choices of their families and that they are at higher risk for the additional health risks associated with obesity affecting pregnancy and birth. Despite the identification of these risk factors, the factors that affect healthy weight management have not been well understood. Using the life course theory, a qualitative inquiry in the form of a structured interview was developed with local …

Patchy Progress On Obesity Prevention: Emerging Exemplars, Entrenched Barriers, And New Thinking, Christina A. Roberto, Boyd Swinburn, Corinna Hawkes, Terry T-K Huang, Sergio Costa, Marice Ashe, Lindsey Zwicker, John H. Cawley, Kelly D. Brownell

Publications and Research

Although there have been positive pockets of change, no country has yet turned around its obesity epidemic. Preventing an increase in obesity prevalence will require urgent actions from government as well as a broader spectrum of stakeholders than previously emphasized. In this paper, we review a number of regulatory and non-regulatory actions taken around the world to address obesity and discuss some of the reasons for the patchy progress. In addition, we preview the papers in this Lancet series, which each identify priority actions on key obesity issues and challenge some of the entrenched dichotomies that present obesity and its …

Are New Sodium Targets In The National School Lunch Program Feasible And Are They Necessary?, Yaneve Shemesh

PCOM Biomedical Studies Student Scholarship

In many societies, high salt intake is a continuing issue in adults, and is of growing concern in children due to the prevalence of processed foods. In response, the USDA has set three targets for sodium in meals offered in the National School Lunch Program (NSLP), and the National School Breakfast Program (NSBP). This 8-year goal is meant to decrease overall sodium levels in both meal programs. However, many associated with school nutrition ask if there is significant evidence to show what effect sodium plays on children’s health, and thus determine if these targets are necessary or achievable. In addressing …

Shared Genetic Variance Between Obesity And White Matter Integrity In Mexican Americans, Elena A. Spieker, Peter Kochunov, Laura M. Rowland, Emma Sprooten, Anderson M. Winkler, Rene L. Olvera, Laura Almasy, Ravi Duggirala, Peter T. Fox, John Blangero, David C. Glahn, Joanne E. Curran

School of Medicine Publications

Obesity is a chronic metabolic disorder that may also lead to reduced white matter integrity, potentially due to shared genetic risk factors. Genetic correlation analyses were conducted in a large cohort of Mexican American families in San Antonio (N = 761, 58% females, ages 18–81 years; 41.3 ± 14.5) from the Genetics of Brain Structure and Function Study. Shared genetic variance was calculated between measures of adiposity [(body mass index (BMI; kg/m2) and waist circumference (WC; in)] and whole-brain and regional measurements of cerebral white matter integrity (fractional anisotropy). Whole-brain average and regional fractional anisotropy values for 10 major …

Effects Of Controlled Whole-Body Vibration Training On Reducing Risk Of Falls Among Young Adults With Obesity, Jose Jesus Munoz

Open Access Theses & Dissertations

Introduction: Among people with obesity, several factors increase the risk of falls: an abnormal body mass distribution, muscle weakness, and postural instability. Although standard exercise-based training could change these factors, a significant portion of people with obesity may be unable or unwilling to comply with long duration and high intensity training programs. Therefore, alternative training methods are highly demanded. Growing evidence supports that controlled whole-body vibration (CWBV) training can reduce risk of falls among older adults. No study has yet investigated the potential effect of CWBV training on reducing risk of falls among obese populations. The purpose of this study …

Restraint Stress Alters Pro-Inflammatory Cytokine Expression And Increases Superoxide Dismutase In The Rat Hypothalamus And Hippocampus, Kristina Isabel Barron

Open Access Theses & Dissertations

The impact of restraint stress on changes in cytokine expression and oxidative stress markers in hippocampal (Hipp) and hypothalamic (Hyp) regions of the brain, were assessed in a rat model. In addition, immune and inflammatory variables were assessed in peripheral blood. Male Wistar rats were acutely (30 min) or repeatedly (30 min/d for 14 consecutive days) exposed to a restraint stress, or maintained as non-stressed controls. At the time of sacrifice, whole blood and brain tissues enriched in Hyp or Hipp regions were collected; blood was collected with EDTA as an anticoagulant and centrifuged to yield plasma. All tissue samples …

Preliminary Nutritional Profile Analysis Of Box Tops 4 Education Food Products, Hannah Griffith

Williams Honors College, Honors Research Projects

The marketing of unhealthy food to children is often cited as a cause of the obesity epidemic.¹ However, most studies that examine this issue evaluated the marketing of food through print or television advertising. This project investigates the marketing of food products to children through incentive based programs, specifically General Mill’s Box Tops 4 Education. This study undertakes a preliminary systematic analysis of Box Tops food items to determine their healthfulness. A subset of all Box Tops food products was selected for review and a basic quantitative content analysis of priority nutrients was performed. Priority nutrients were identified …

Potential Role Of Protein Kinase Cbeta In High Fat Diet-Induced Adipose Dysfunction By Regulating Autophagy Levels, Neil Mehta

Williams Honors College, Honors Research Projects

Obesity is the most common nutritional disorder in the United States and worldwide. Public health efforts and other anti-obesity measures clearly have not controlled the obesity epidemic. There is a great need to understand the pathogenic mechanisms underlying fat accumulation. Research of the past decade supports a prominent role for diet-induced adipose tissue dysfunction in the development and/or progression of obesity and associated insulin resistance. Potential mechanisms for the development of adipose tissue dysfunction include ectopic (visceral) fat accumulation, genetic factors, and alterations in autophagy and inflammatory processes. However, the molecular mechanisms linking dietary fat intake with alterations in adipose …

Health-Related Beliefs Among Low-Income African American Women And Their Perceptions About Obesity, Cenora Kimberly Akhidenor

Walden Dissertations and Doctoral Studies

The aim of this study was to explore the health-related beliefs and perceptions of low-income African American women regarding obesity. Phenomenology served as the conceptual framework for this study. African American women, especially those in low-income brackets, have been shown to weigh more than women of other racial/ethnic groups. The consequences of these high rates are increased risks of developing chronic health disorders, such as type II diabetes and cardiovascular disease. The study sample consisted of 7 low-income obese African American women, ranging in age from 20 to 62, who resided in the Pacific Northwest. Recruitment for participation occurred via …