Medicine and Health Sciences Commons^™

Tobacco, Alcohol, And Processed Food Industries – Why Do Public Health Practitioners View Them So Differently?, Katherine Smith, Lori Dorfman, Nicholas Freudenberg, Benjamin Hawkins, Shona Hilton, Oliver Razum, Heide Weishaar

Publications and Research

No abstract provided.

Winning The Obesity Battle, Daniel S. Blumenthal

Journal of the Georgia Public Health Association

Winning the Obesity Battle

Adapting A Physical Activity Intervention For Youth In A Rural Area: A Case Study, Moya L. Alfonso, Gavin Golquitt, Ashley Walker, Akrati Gupta

Journal of the Georgia Public Health Association

Background: Physical activity offers children and youth many well-documented positive effects on health. The present study adapted a community-based prevention marketing campaign (CBPM), VERBTM Summer Scorecard (VSS) to promote physical activity among minority youth in rural, southeast Georgia. The purpose of this paper is to describe the adaptation process, emphasizing methods used and lessons learned.

Methods: A qualitative study design was used to identify social marketing concepts that informed program adaptation, including two focus groups with 12 children and two focus groups with 14 parents. Qualitative thematic data analysis was used to analyze formative research. The adapted program was implemented …

Gender Disparities In Weight Gain Among Offenders Who Are Obese Upon Entering Correctional Facilities, Madison L. Gates, Nancy C. Webb, Rebecca Stone, Darra Ballance, Wonsuk Yoo

Journal of the Georgia Public Health Association

Background: Obesity is a significant health issue for offenders, who have a higher prevalence of obesity-related conditions, such as diabetes, compared to non-incarcerated populations. Within incarcerated populations, there are obesity disparities in terms of race, gender, and age, as well as excess weight gain during incarceration.

Methods: This longitudinal study was conducted for 2005 – 2010 in collaboration with a Department of Corrections in the east south central region of the United States. From electronic health records of 10,841 offenders, weight, height, and demographic data were extracted. As determined from these data, 2,622 offenders met the inclusion criteria (two or …

Growing Fit: Georgia’S Model For Engaging Early Care Environments In Preventing Childhood Obesity, Kelsey Mcdavid, Catalina Piedrahita, Emily A. Vall, Christi Kay, Jean O’Connor

Journal of the Georgia Public Health Association

Background: In the United States, one in three children is overweight or obese by their fifth birthday. In Georgia, 35 percent of children are overweight or obese. Contrary to popular belief, children who are overweight or obese are unlikely to outgrow their weight status as adults, making early childhood an essential time to address weight status. An estimated 380,000 Georgia children attend early care and education environments, such as licensed child care centers, Head Start, and pre-kindergarten programs, which provide an opportunity to reach large numbers of children, including those at risk for obesity and overweight.

Methods: To address this …

The Association Between Obesity, Depression, And Anxiety: Evidence From A Community Health Needs Assessment Survey, Grace B. Adams, Angela Murcia

Journal of the Georgia Public Health Association

Background: The obesity epidemic has garnered much attention as a public health crisis. In order to make progress, it is necessary to understand the factors associated with obesity. One area of research needing more development is the link between obesity and other chronic health conditions. The objective of the present study was to further understand the relationship between obesity and the prevalence of anxiety and depression in Athens-Clarke County in northeast Georgia.

Methods: Data from the 2015 Athens-Clarke County Community Health Needs Assessment (n=1234) were used to assess the relationship between obesity and the prevalence of anxiety and depression among …

Weight Status And Satisfaction With Healthcare Received In The U.S. And Georgia, Saswat Panda, Koichiro Otani, Janani R. Thapa

Journal of the Georgia Public Health Association

Background: Two-thirds of the U.S. population is overweight or obese, and, in Georgia, adult obesity rates are among the highest. Obesity is a risk factor for diabetes, heart disease, stroke, and some types of cancer, and adherence to treatment of such disease conditions is affected by patients’ perception of healthcare received. The present study examined the association between weight status and satisfaction with healthcare received in the U.S. and in Georgia.

Methods: The association between weight status and satisfaction with healthcare received in the U.S. and Georgia was examined using multiple logistic regression analyses, controlling for demographic and other healthcare-related …

Using The Exercise Is Medicine® On Campus Platform To Assess College Students’ Practice Of Physical Activity In A Rural Setting, Bridget Melton, Jazmin A. Williamson, Helen Bland, Jian Zhang

Journal of the Georgia Public Health Association

Background: The college setting offers public health educators and exercise scientists a favorable environment to implement wide-spread change in levels of physical activities. With over two-thirds of all adults in the U.S. now categorized as obese or overweight (CDC, 2015), it has become necessary to increase physical activity levels on college campuses. Exercise is Medicine® on Campus (EIM®-OC) is a national initiative to increase physical activity on college campuses by creating an environment to change the subjective norm of diminished exercise movement and fitness among adults. The purpose of the present study was to use the EIM®-OC platform to assess …

Genome-Wide Association Studies Suggest Sex-Specific Loci Associated With Abdominal And Visceral Fat, Yun Ju Sung, L. Pérusse, M. A. Sarzynski, M. Fornage, S. Sidney, B. Sternfeld, T. Rice, J. G. Terry, D. R. Jacobs Jr., John Blangero, Joanne E. Curran

School of Medicine Publications

Background:

To identify loci associated with abdominal fat and replicate prior findings, we performed genome-wide association (GWA) studies of abdominal fat traits: subcutaneous adipose tissue (SAT); visceral adipose tissue (VAT); total adipose tissue (TAT) and visceral to subcutaneous adipose tissue ratio (VSR).

Subjects and Methods:

Sex-combined and sex-stratified analyses were performed on each trait with (TRAIT–BMI) or without (TRAIT) adjustment for body mass index (BMI), and cohort-specific results were combined via a fixed effects meta-analysis. A total of 2513 subjects of European descent were available for the discovery phase. For replication, 2171 European Americans and 772 African Americans were available. …

Evaluation Of A Diabetes Prevention Program For Rural Citizens, Barbara B. Kawulich, Diana Mindrila, Gina Brandenburg

Journal of the Georgia Public Health Association

Background: Georgia has one of the highest rates of diabetes in the US. Obesity and inactivity contribute to the onset of this disease. Tanner Health System addressed the obesity epidemic in three rural counties of Georgia through a 16-week diabetes prevention program (DPP) for 176 residents. This study evaluated the effectiveness of the DPP.

Methods: The multiple methods design of this project used pre- and post-surveys from January/February, 2014, classes to determine diabetes-related lifestyle factors, 11 mid-point telephone interviews, and focus groups with 17 members to identify lifestyle changes that were implemented. Additionally, initial and final measurements of body mass …

The Need For Culturally-Tailored Smartphone Applications For Weight Control, Stephen S. Coughlin, Dale Hardy, Lee S. Caplan

Journal of the Georgia Public Health Association

Background: Approximately 35% of U.S. adults are obese, and this rate is expected to increase by almost 50% by 2030. New media such as smartphone applications (apps) provide a useful and low-cost way to disseminate weight control information. For many culturally distinctive population subgroups, however, there is currently an absence of research-tested smartphone apps for weight control.

Methods: In this commentary, we highlight the need for culturally tailored smartphone apps for weight control and offer recommendations for further research by providing two specific examples: 1) the characteristic dietary patterns and absence of smartphone apps for weight loss for Hispanic Americans, …

A Quantile Regression Approach To Measuring The Educational Effect On Body Mass Index, Dakshina G. De Silva, Bradley T. Ewing, Catherine P. Slade, Mark A. Thompson

Journal of the Georgia Public Health Association

Background: By use of a publically available database, the effects of education and geography on obesity as measured by body mass index (BMI) were evaluated with a quantile regression approach. The focus of the analysis was on the practical interpretation of the regression results to inform health policy decision makers about the importance of educational attainment for the growing public health issue of obesity in the US, particularly in the Southeast.

Methods: With data from the 2007 Behavioral Risk Factor Surveillance System (BRFSS), quantile regressions were employed to estimate the educational effect on BMI while controlling for relevant lifestyle, socioeconomic, …

Targeting Iκb Kinase Β In Adipocyte Lineage Cells For Treatment Of Obesity And Metabolic Dysfunctions, Robert N. Helsley, Yipeng Sui, Se-Hyung Park, Zun Liu, Richard G. Lee, Beibei Zhu, Philip A. Kern, Changcheng Zhou

Clinical and Translational Science Faculty Publications

IκB kinase β (IKKβ), a central coordinator of inflammation through activation of nuclear factor-κB, has been identified as a potential therapeutic target for the treatment of obesity-associated metabolic dysfunctions. In this study, we evaluated an antisense oligonucleotide (ASO) inhibitor of IKKβ and found that IKKβ ASO ameliorated diet-induced metabolic dysfunctions in mice. Interestingly, IKKβ ASO also inhibited adipocyte differentiation and reduced adiposity in high-fat (HF)-fed mice, indicating an important role of IKKβ signaling in the regulation of adipocyte differentiation. Indeed, CRISPR/Cas9-mediated genomic deletion of IKKβ in 3T3-L1 preadipocytes blocked these cells differentiating into adipocytes. To further elucidate the role of …

Anti-Fat Attitudes And Weight Bias Internalization: An Investigation Of How Bmi Impacts Perceptions, Opinions And Attitudes, Laurie Schrider

USF Tampa Graduate Theses and Dissertations

Americans hold negative and judgmental attitudes towards obese and overweight individuals and these anti-fat attitudes and weight stigma have become a damaging form of discrimination. The internalization of weight bias and anti-fat attitudes contributes to negative health outcomes including: feelings of devalue, self-hate, anxiety, depression, body dissatisfaction and eating disturbances. The purpose of this study was to investigate weight bias internalization in individuals who perceive themselves as overweight as well as to examine differences in anti-fat attitudes among normal and overweight individuals. A sample of 202 male and females completed an online survey that assessed anti-fat attitudes via the Anti-Fat …

Depression And Body Mass Index, Differences By Education: Evidence From A Population-Based Study Of Adult Women In The U.S. Buffalo-Niagara Region, Ashley Wendell Kranjac, Jing Nie, Maurizio Trevisan, Jo L. Freudenheim

Sociology Faculty Articles and Research

The relationship between obesity and depression is well described. However, the evidence linking depression and body mass index (BMI) across the broad range of body size is less consistent. We examined the association between depressive symptoms and BMI in a sample of adult women in the Buffalo-Niagara region between 1997 and 2001. Using logistic regression, we investigated whether increased weight status beyond normal-weight was associated with a higher prevalence of depressive symptoms, and if educational attainment modified the association between obesity and depression. There was a trend for increased weight status to be associated with higher depressive symptoms (obese II/III, …

Dielectric Properties Measurements Of Brown And White Adipose Tissue In Rats From 0.5 To 10 Ghz, Dario B. Rodrigues, Paul R. Stauffer, E. Colebeck, A. Z. Hood, S. Salahi, P. F. Maccarini, E. Topsakal

Department of Radiation Oncology Faculty Papers

Brown adipose tissue (BAT) plays an important role in whole body metabolism and with appropriate stimulus could potentially mediate weight gain and insulin sensitivity. Although imaging techniques are available to detect subsurface BAT, there are currently no viable methods for continuous acquisition of BAT energy expenditure. Microwave (MW) radiometry is an emerging technology that allows the quantification of tissue temperature variations at depths of several centimeters. Such temperature differentials may be correlated with variations in metabolic rate, thus providing a quantitative approach to monitor BAT metabolism. In order to optimize MW radiometry, numerical and experimental phantoms with accurate dielectric properties …

Are Dietary Intakes Related To Obesity In Children?, Dimitrios Papandreou, Kali Makedou, Areti Zormpa, Maria Karampola, Anastasia Ioannou, Areti Hitoglou-Makedou

All Works

AIM: The purpose of this study was to report obesity status and identify any dietary substances that may be related to obesity in healthy school children from Northern Greece. METHODS: Four hundred and twenty-five (n = 425) children were randomly selected to participate in the study. A 24-h recall of three days (two weekdays and one weekend day) was used to analyze the dietary data of the subjects. RESULTS: Out of 425 subjects, 146 (34.3%) of them were found to be overweight and obese. Energy, protein, carbohydrate and thiamin intake was statistically positively correlated with obesity while dietary iron intake …

Decreasing Obesity And Obesity Stigma: Socio-Demographic Differences In Beliefs About Causes Of And Responsibility For Obesity, Christy F. Brady

Sociology Faculty Publications

Obesity is a stigmatized condition, and research has shown that obesity stigma varies based on the perceived cause of obesity. It is important that public health professionals develop policy and campaigns that resonate with specific populations while avoiding an increase in harmful stigma. This study identifies socio-demographic differences in causal attributions of obesity and beliefs about responsibility for obesity. Using data from a survey of 923 people in the United States conducted by ABC New/Time Magazine, attributions of cause and responsibility are analyzed using Ordinary Least Squares regression. Beliefs about cause and responsibility fall on a continuum from primarily individual …

Promotion Of Drinking Water Among Latino Immigrant Youth, Nicole Barrett, Allison Elkins, Uriyoan Colón-Ramos, Ivonne Rivera, W. Douglas Evans, Mark Edberg

GW Research Days 2016 - 2020

Objective: To design an innovative intervention to increase drinking water behaviors among Latino immigrant youth.

Methods: We conducted two rounds of focus groups, totaling 10 sessions (n=61), with Latino immigrant youth, aged 6-18 years, living in Langley Park, Maryland. Participants were stratified into focus groups by age group (elementary, middle, and high school) and language preference (Spanish and English). A professional, bilingual-speaking moderator used a semistructured discussion guide to examine: (1) what youth preferred to drink in different settings and why, (2) their reactions to promotional messages, (3) slogans that would entice them to drink more water in school and …

Walking Mediates Associations Between Neighborhood Activity Supportiveness And Bmi In The Women's Health Initiative San Diego Cohort., Jordan A. Carlson, Rosemay A. Remigio-Baker, Cheryl A M Anderson, Marc A. Adams, Gregory J. Norman, Jacqueline Kerr, Michael H. Criqui, Matthew Allison

Manuscripts, Articles, Book Chapters and Other Papers

OBJECTIVES: To investigate whether walking mediates neighborhood built environment associations with weight status in middle- and older-aged women.

METHODS: Participants (N=5085; mean age=64 ± 7.7; 75.4% White non-Hispanic) were from the Women's Health Initiative San Diego cohort baseline visits. Body mass index (BMI) and waist circumference were measured objectively. Walking was assessed via survey. The geographic information system (GIS)-based home neighborhood activity supportiveness index included residential density, street connectivity, land use mix, and number of parks.

RESULTS: BMI was 0.22 units higher and the odds ratio for being obese (vs. normal or overweight) was 8% higher for every standard deviation …

Social Incentives In Pervasive Fitness Apps For Obese And Diabetic Patients, Yu Chen, Mirana Randriambelonoro, Antoine Geissbuhler, Pearl Pu

Faculty Publications, Information Systems & Technology

Social incentives such as cooperation and competition are found to motivate users in pervasive fitness applications. This work investigates how social incentives work for individuals with obesity and diabetes. We used a mobile fitness application called HealthyTogether as an experimental platform, which allows dyads to achieve fitness goals together and compete in an online community. We conducted a fourweek study with 16 obese and diabetic patients who used HealthyTogether to exercise with a buddy. Results show that participants exercised more with social incentives compared with their baseline. Collaborating with buddies to compete in a community was reported as motivating for …

Genome-Wide Meta-Analysis Uncovers Novel Loci Influencing Circulating Leptin Levels, Tuomas O. Kilpeläinen, Jayne F.Martin Carli, Alicja A. Skowronski, Qi Sun, Jennifer Kriebel, Mary F. Feitosa, Åsa K. Hedman, Alexander W. Drong, James E. Hayes, John Blangero

School of Medicine Publications

Leptin is an adipocyte-secreted hormone, the circulating levels of which correlate closely with overall adiposity. Although rare mutations in the leptin (LEP) gene are well known to cause leptin deficiency and severe obesity, no common loci regulating circulating leptin levels have been uncovered. Therefore, we performed a genome-wide association study (GWAS) of circulating leptin levels from 32,161 individuals and followed up loci reaching P<10−6 in 19,979 additional individuals. We identify five loci robustly associated (P<5 × 10−8) with leptin levels in/near LEP, SLC32A1, GCKR, CCNL1 and FTO. Although the association of the FTO obesity locus with leptin levels is abolished by adjustment for BMI, associations of the four other loci …

Physical Examination Findings Among Children And Adolescents With Obesity: An Evidence-Based Review., Sarah Armstrong, Suzanne Lazorick, Sarah Hampl, Joseph A. Skelton, Charles Wood, David Collier, Eliana M. Perrin

Manuscripts, Articles, Book Chapters and Other Papers

Overweight and obesity affects 1 in 3 US children and adolescents. Clinical recommendations have largely focused on screening guidelines and counseling strategies. However, the physical examination of the child or adolescent with obesity can provide the clinician with additional information to guide management decisions. This expert-based review focuses on physical examination findings specific to children and adolescents with obesity. For each physical examination element, the authors define the finding and its prevalence among pediatric patients with obesity, discuss the importance and relevance of the finding, describe known techniques to assess severity, and review evidence regarding the need for additional evaluation. …

Project Energize: Intervention Development And 10 Years Of Progress In Preventing Childhood Obesity Public Health, Elaine Rush, Carolyn Cairncross, Margaret Hinepo Williams, Marilyn Tseng, Tara Coppinger, Steph Mclennan, Kasha Latimer

Publications

Prevention of childhood obesity is a global priority. The school setting offers access to large numbers of children and the ability to provide supportive environments for quality physical activity and nutrition. This article describes Project Energize, a through-school physical activity and nutrition programme that celebrated its 10-year anniversary in 2015 so that it might serve as a model for similar practices, initiatives and policies elsewhere. The programme was envisaged and financed by the Waikato District Health Board of New Zealand in 2004 and delivered by Sport Waikato to 124 primary schools as a randomised controlled trial from 2005 to 2006. …

Ceramide Induces Human Hepcidin Gene Transcription Through Jak/Stat3 Pathway., Sizhao Lu, Sathish Kumar Natarajan, Justin L. Mott, Kusum K. Kharbanda, Duygu Dee Harrison-Findik

Journal Articles: Biochemistry & Molecular Biology

Changes in lipid metabolism and iron content are observed in the livers of patients with fatty liver disease. The expression of hepcidin, an iron-regulatory and acute phase protein synthesized by the liver, is also modulated. The potential interaction of lipid and iron metabolism is largely unknown. We investigated the role of lipid intermediate, ceramide in the regulation of human hepcidin gene, HAMP. Human hepatoma HepG2 cells were treated with cell-permeable ceramide analogs. Ceramide induced significant up-regulation of HAMP mRNA expression in HepG2 cells. The effect of ceramide on HAMP expression was mediated through transcriptional mechanisms because it was completely blocked …

Ceramide Induces Human Hepcidin Gene Transcription Through Jak/Stat3 Pathway., Sizhao Lu, Sathish Kumar Natarajan, Justin L. Mott, Kusum K. Kharbanda, Duygu Dee Harrison-Findik

Journal Articles: Biochemistry & Molecular Biology

Changes in lipid metabolism and iron content are observed in the livers of patients with fatty liver disease. The expression of hepcidin, an iron-regulatory and acute phase protein synthesized by the liver, is also modulated. The potential interaction of lipid and iron metabolism is largely unknown. We investigated the role of lipid intermediate, ceramide in the regulation of human hepcidin gene, HAMP. Human hepatoma HepG2 cells were treated with cell-permeable ceramide analogs. Ceramide induced significant up-regulation of HAMP mRNA expression in HepG2 cells. The effect of ceramide on HAMP expression was mediated through transcriptional mechanisms because it was completely blocked …

Obesity-Induced Colorectal Cancer Is Driven By Caloric Silencing Of The Guanylin-Gucy2c Paracrine Signaling Axis., Jieru E. Lin, Francheska Colon-Gonzalez, Erik S. Blomain, Gilbert W. Kim, Amanda Aing, Brian Stoecker, Justin Rock, Adam E. Snook, Tingting Zhan, Terry M. Hyslop, Michal Tomczak, Richard S. Blumberg, Scott A. Waldman

Department of Pharmacology and Experimental Therapeutics Faculty Papers

Obesity is a well-known risk factor for colorectal cancer but precisely how it influences risks of malignancy remains unclear. During colon cancer development in humans or animals, attenuation of the colonic cell surface receptor guanylyl cyclase C (GUCY2C) that occurs due to loss of its paracrine hormone ligand guanylin contributes universally to malignant progression. In this study, we explored a link between obesity and GUCY2C silencing in colorectal cancer. Using genetically engineered mice on different diets, we found that diet-induced obesity caused a loss of guanylin expression in the colon with subsequent GUCY2C silencing, epithelial dysfunction, and tumorigenesis. Mechanistic investigations …

The Benefits Of Body Mass Index And Waist Circumference In The Assessment Of Health Risk, Mary T. Imboden, Alexander H.K. Montoye, Leonard A. Kaminsky

Faculty Publications - Department of Kinesiology

Obesity is an epidemic in the United States. Most health and fitness (H&F) professionals are familiar with reports showing that 69% of American adults are overweight, and an estimated 36.5%are obese, defined as having a body mass index (BMI) of 25 kg/m2 or higher and 30 kg/m2 or higher, respectively. Thus, 78.6 million American adults are considered to have excess weight that is detrimental to their health (16,17,19). In 2014, there was not a single state with a prevalence of obesity of less than 20%, and 19 states were reported to have an obesity prevalence of more than 30%. This …

Impact Of Morbid Obesity On Left Ventricular Assist Device Support And Heart Transplantation, Sophia Cohen, Daniel Tang Md

MD Student Summer Research Fellowship Program Posters

Morbidly obese patients requiring LVAD support encounter higher postoperative complications and wait longer for heart transplantation, however heart transplant and graft survival is comparable. Our study suggests that carefully selected morbidly obese patients should undergo LVAD placement and heart transplantation. However, our study was limited by a very small sample size and by the biases inherent to a retrospective data analysis.

Pre-Pregnancy Obesity And Non-Adherence To Multivitamin Use: Findings From The National Pregnancy Risk Assessment Monitoring System (2009–2011), Saba W. Masho, Amani Bassyouni, Susan Cha

Family Medicine and Population Health Publications

Background

Although adequate folic acid or multivitamins can prevent up to 70 % of neural tube defects, the majority of U.S. non-pregnant women of childbearing age do not use multivitamins every day. Factors influencing consistent multivitamin use are not fully explored. This study aims to investigate the association between pre-pregnancy body mass index (BMI) and multivitamin use before pregnancy using a large, nationally representative sample of women with recent live births.

Methods

The national 2009–2011 Pregnancy Risk Assessment Monitoring System data were analyzed. The sample included women with recent singleton live births (N = 104,211). The outcome of interest …