Medicine and Health Sciences Commons^™

A Deep Dive Into The Relationship Between Sleep Deprivation And Pain Perception: A Cross-Population Analysis, Adam T. Friedman, Kevin Regan

Rowan-Virtua Research Day

Background: Sleep deprivation and pain perception significantly impact one another through altered sleep parameters such as Total Sleep Time (TST) and Sleep Efficiency (SE). Particularly in neuropathic pain, disturbed sleep exacerbates pain by disrupting neurobiological mediators like opioids and serotonin. Our research examined how sleep loss affects pain in chronic conditions versus healthy individuals. This research underpins our analysis of how interventions, possibly nutritional, could improve sleep quality and modulate pain perception, exploring this relationship across diverse populations and conditions.

Methods: Our study reviewed peer-reviewed articles published since 2010 on sleep deprivation and pain perception. We searched PubMed, focusing on …

Biopsychosocial Management Of Long Covid Fibromyalgia: Lessons From The Penn Medicine Lancaster General Health Fibromyalgia Program, Joseph Harrison, Dennis Given Psy.D.

The Journal of Integrated Primary Care

The COVID-19 pandemic has increased the prevalence of chronic health concerns worldwide, leading to a new population of patients suffering from Long Covid. Patients with Long Covid often experience persistent symptoms impacting multiple organ systems, including neuroimmune and neurological manifestations. Recently, attention has grown toward Long Covid patients developing chronic widespread pain similar to fibromyalgia. Fibromyalgia is a nociplastic pain disorder characterized by widespread pain and central sensitization with fatigue, sleep disturbances, and impairments in cognitive functioning. Given the nascent and limited research exploring new treatment options, patients need support now from biopsychosocial multi-modal pain management strategies. The Fibromyalgia Program …

Prevalence Of Fibromyalgia And Chronic Fatigue Syndrome Among Individuals With Irritable Bowel Syndrome: An Analysis Of United States National Inpatient Sample Database, Zahid Ijaz Tarar, Umer Farooq, Ahmad Nawaz, Mustafa Gandhi, Yezaz A Ghouri, Asmeen Bhatt, Brooks D Cash

Journal Articles

Background and Aim: Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder associated with other somatic disorders. We studied the prevalence and predictors of fibromyalgia and chronic fatigue syndrome (CFS) in IBS patients. Methods: We used the National Inpatient Sample and included hospitalization of individuals with IBS, using ICD-10 codes, from 2016–2019. The prevalence and predictors of fibromyalgia and CFS in IBS patients were studied. Univariate and multivariate patient- and hospital-level regression models were used to calculate the adjusted odds of fibromyalgia and CFS in the IBS patient population. Results: Of 1,256,325 patients with an ICD-10 code of IBS included …

Exploring The Viability Of A Microglia Attenuating Treatment Model For Fibromyalgia Patients, Rohan Yarlagadda

Rowan-Virtua Research Day

Fibromyalgia refers to a rheumatic condition experienced as pain all over the body without a specific cause. This is considered a diagnosis of exclusion. This classification seems to suggest that any treatment options for it are purely symptomatic and are not disease targeted. Its complex diagnosis and underlying pathology contribute to the challenge of medically addressing fibromyalgia. Without a strict cause, fibromyalgia is often treated symptomatically with CBT and SNRIs. However, recent research suggests that existing therapeutic approaches are not very effective, especially when considering long term benefits for this chronic condition. This beckons for novel treatment options for these …

Higher Efficacy In The Treatment Of Fibromyalgia With Duloxetine And Pregabalin Combination Than Monotherapy, Joel Rose-Kamprath

Clinical Research in Practice: The Journal of Team Hippocrates

A clinical decision report using:

Gilron I, Chaparro LE, Tu D, et al. Combination of pregabalin with duloxetine for fibromyalgia. Pain. 2016;157(7):1532–1540. https://doi.org/10.1097/j.pain.0000000000000558

for a patient with chronic pain due to fibromyalgia

Impact Of Moderate Physical Exercise On Sleep Disorders In Patients With Fibromyalgia, Sylvia G. Alfaro-Castro

Revista de la Facultad de Medicina Humana

Introduction: Fibromyalgia (FM) or Fibromyalgia Syndrome (FMS) is currently defined as a chronic condition of unknown cause characterized by generalized pain, among other symptoms, in the absence of a specific organic disease. Sleep disorders are recognized as one of the main symptoms in fibromyalgia patients, and performing various types of physical activity in this group of patients could improve sleep quality and other sleep disorders. Objective: To determine if the performance of moderate physical exercise has a positive impact on sleep disorders in patients with fibromyalgia. Methods: A PubMed search was carried out, where 2616 articles were found in the …

Hear My Voice: Qualitative Studies To Explore What Empowers Patients To Talk With Their Doctor And Participate In Making Health Care Decisions, Alicia Marie Oostdyk

Theses and Dissertations

Patients with fibromyalgia are faced with many decisions throughout the process of seeking and obtaining health care. For patients to feel empowered to take action, it is essential they feel as if they can play a role in making decisions up to their desired level of participation. However, it is unclear what constitutes empowerment in shared decision making between patients and providers. For patients with fibromyalgia, who deal with complex symptomology and individualized treatment choice, it is important to know what makes them feel empowered to participate in care. The objective of this dissertation is to create a patient-centered definition …

Pain And Sleep Are Associated In Fibromyalgia Patients, Rahul Patel, Robert A Steer, Richard Jermyn, Venkat Venkataraman

Rowan-Virtua Research Day

This poster explores whether a correlation exists between lack of sleep and fibromyalgia pain.

Attention-Deficit Hyperactivity Disorder Symptoms And Quality Of Life In Female Patientswith Fibromyalgia, Gözde Türkoğlu, Yavuz Selvi̇

Turkish Journal of Medical Sciences

Background/aim: The present study aimed to determine the association between attention-deficit hyperactivity disorder (ADHD) symptoms severity, fibromyalgia (FM) severity, and QoL. Materials and methods: While the FM group consisted of 113 (74%) patients, the control group consisted of 40 (26%) individuals. FM symptom severity, ADHD symptom severity, and QoL were evaluated using the fibromyalgia impact questionnaire (FIQ), adult ADHD self-report scale (ASRS), and World Health Organization quality of life scale-brief version (WHOQOL-BREF), respectively. Results: It was found that the FM group had significantly higher scores on the ASRS than the control group (p < 0.05). There was a significant difference in FIQ scores and three WHOQOL-BREF domain scores between the FM alone and comorbid FM/high probability of ADHD groups (p < 0.05). We found a negative correlation between ASRS total scores and all other scale scores (except for the social relationships domain score of the WHOQOL-BREF) and a positive correlation between ASRS total scores and FIQ scores in FM patients. ADHD scores would mediate the relationship between depression severity and QoL. Conclusions: Our findings indicated that the presence of ADHD symptoms was related to greater FM symptom severity and poorer QoL. Also, ADHD scores would mediate the relationship between depression severity and QoL.

Chronic Muscle Pain, Michael Bozzi, Md

Department of Family & Community Medicine Presentations and Grand Rounds

Learning Objectives ●How to approach the patient with chronic muscle pain ●How a complete history and physical can prevent extraneous testing and unnecessary or premature referrals ●Treatment strategies

Low-Dose Naltrexone For Treatment In Crohn’S Disease And Fibromyalgia, Hannah Rachel Tkach

Physician Assistant Scholarly Project Papers

The United States has experienced a dramatic increase in opioid abuse and overdoses, leading to a national epidemic. Contributing to this epidemic is the use of opioid therapy for complex chronic inflammatory and neuropathic conditions that remain difficult to treat. Many traditional treatments are ineffective or have intolerable side effects, forcing providers to utilize opioid therapy as a last resort. Recently, there is increased interest in the use of partial opioid antagonist naltrexone to treat Crohn’s disease and fibromyalgia. Previous research suggests the potential for naltrexone to provide analgesic effects when administered in low doses via its unique interaction with …

Low-Dose Naltrexone For Treatment In Crohn’S Disease And Fibromyalgia, Hannah R. Tkach

Physician Assistant Scholarly Project Posters

The United States has experienced a dramatic increase in opioid abuse and overdoses, leading to a national epidemic. Contributing to this epidemic is the use of opioid therapy for complex chronic inflammatory and neuropathic conditions that remain difficult to treat. Many traditional treatments are ineffective or have intolerable side effects, forcing providers to utilize opioid therapy as a last resort. Recently, there is increased interest in the use of partial opioid antagonist naltrexone to treat Crohn’s disease and fibromyalgia. Previous research suggests the potential for naltrexone to provide analgesic effects when administered in low doses via its unique interaction with …

Pain, Functional Disability, And Their Association In Juvenile Fibromyalgia Compared To Other Pediatric Rheumatic Diseases., Mark Connelly, Jennifer E Weiss, Carra Registry Investigators

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: Severe pain and impairments in functioning are commonly reported for youth with juvenile fibromyalgia. The prevalence and impact of pain in other diseases commonly managed in pediatric rheumatology comparatively have been rarely systematically studied. The objective of the current study was to determine the extent to which high levels of pain and functional limitations, and the strength of their association, are unique to youth with juvenile primary fibromyalgia syndrome/JPFS) relative to other pediatric rheumatic diseases.

METHODS: Using data from 7753 patients enrolled in the multinational Childhood Arthritis and Rheumatology Research Alliance (CARRA) Legacy Registry, we compared the levels and …

Demographic, Clinical, And Treatment Characteristics Of The Juvenile Primary Fibromyalgia Syndrome Cohort Enrolled In The Childhood Arthritis And Rheumatology Research Alliance Legacy Registry., Jennifer E. Weiss, Kenneth N. Schikler, Alexis D. Boneparth, Mark Connelly, Carra Registry Investigators

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: To describe the demographic, clinical, and treatment characteristics of youth diagnosed with juvenile primary fibromyalgia syndrome (JPFS) who are seen in pediatric rheumatology clinics.

METHODS: Information on demographics, symptoms, functioning, and treatments recommended and tried were obtained on patients with JPFS as part of a multi-site patient registry (the Childhood Arthritis and Rheumatology Research Alliance Legacy Registry). Data were summarized using descriptive statistics. In a subset of patients completing registry follow-up visits, changes in symptoms, pain, and functioning were evaluated using growth modeling.

RESULTS: Of the 201 patients with JPFS enrolled in the registry, most were Caucasian/White (85%), non-Hispanic …

Understanding The Role Of Cognitive Behavioral Therapy Among Women With Fibromyalgia: A Review Of The Literature, Emily Hall

All Electronic Theses and Dissertations

Background: Women with fibromyalgia (FM) experience a range of symptoms threatening the integrity of their overall wellbeing. Since no cure exists, management to reduce symptoms, disability, and improve functionality is the focus. Promising outcomes have been demonstrated when cognitive behavioral therapy (CBT) is used as a complementary measure to other treatments to increase an individual’s coping mechanisms through various exercises. Purpose: The Theory of Unpleasant Symptoms (TOUS), introduced by Elizabeth Lens and colleagues in 1995, provided a guiding framework to evaluate the effectiveness of multidisciplinary therapy with CBT in controlling influencers of pain and general symptom intensity. Results: Nineteen studies …

A Nationwide Comparative Analysis Of Medical Complications In Fibromyalgia Patients Following Total Knee Arthroplasty, T. Moore, N. Sodhi, A. Kalsi, R. M. Vakharia, J. O. Ehiorobo, H. K. Anis, K. Dushaj, V. Papas, G. Scuderi, M. A. Mont, +2 Additional Authors

Journal Articles

No abstract provided.

Is Acupuncture An Effective Treatment For Alleviating Fibromyalgia?, Brittney Beckmon-Forrester

PCOM Physician Assistant Studies Student Scholarship

OBJECTIVE: The objective of this selective EBM review is to determine whether or not acupuncture is an effective treatment for alleviating fibromyalgia.

STUDY DESIGN: Systematic review of three randomized controlled trials published in 2014, 2016, and 2017.

DATA SOURCES: Data sources for this review were articles published in peer-reviewed journals using PubMed Database.

OUTCOME(S) MEASURED: The outcome measured was the patients decrease in pain intensity through the use of the visual analog scale.

RESULTS: Stival et al. (2014) found that the change in pain for patients who received true acupuncture to be statistically significant with a p-value of 0.0001. Ugurle …

Is Music Therapy Effective At Reducing Pain In Fibromyalgia Patients?, Amanda M. Vicznesky

PCOM Physician Assistant Studies Student Scholarship

The objective of this selective evidence based medicine (EBM) review is to determine whether or not music therapy is effective at treating pain in fibromyalgia patients.

STUDY DESIGN: This is a systematic review of three primary studies that were peer-reviewed published between the years of 2013-2016.

DATA SOURCES: Two randomized control trials and one cross-control study evaluating if music therapy is affective at treating pain in fibromyalgia patients. Data sources obtained for this review were found using PubMed Database.

OUTCOMES MEASURED: The outcome measured was the effectiveness of music therapy at reducing pain in fibromyalgia patients. Outcomes were measured via …

From Witch Hunts To Autoantibodies: Overcoming Psychogenic Stigma To Uncover The Molecular Cause Of Autoimmunity, Emma Hainstock

Regis University Student Publications (comprehensive collection)

Due to the frequency of misdiagnosis of autoimmune diseases and their disproportionate incidence in women, my thesis explores historical misconceptions about autoimmune conditions which could have lingered in society to impede their diagnoses today. Antiphospholipid Antibody Syndrome (APS) and Anti-NMDA Receptor Encephalitis (ANRE) are the conditions I focused on, as both diseases can cause complex neurologic symptoms such as hallucinations and memory loss, which in combination with the fact that they are disproportionately suffered by women, have caused physicians in the past to misdiagnose patients as either hysteric or demonically possessed. I explore antiphospholipid antibody syndrome and anti-NMDA receptor encephalitis’s …

Complementary And Integrative Therapies For The Treatment Of Fibromyalgia, Jennifer Hushla

Honors Undergraduate Theses

Fibromyalgia syndrome (FMS) is a debilitating and chronic condition with an array of symptoms, the most distinguishable being widespread pain. FMS patients experience a marked decrease in quality of life related to intensity of symptoms. Current treatment options and pharmaceuticals do not provide adequate relief. This thesis examines integrative and complementary therapy options for symptom management and improvement of quality of life for FMS patients. A literature review was conducted of English current research using multiple databases. Findings indicate mindful movement therapies (MMT) such as yoga and tai chi, mindfulness, sensory-related relaxation techniques with guided imagery, and cognitive behavioral therapy …

Laughter Frequency, Pain Perception, And Affect In Fibromyalgia Patients, Deidre Gayl Molchan

Walden Dissertations and Doctoral Studies

Fibromyalgia syndrome (FMS), a common chronic pain condition, is often incompletely treated by conventional medical therapies. It can cause disability, psychological distress, work-related absenteeism, increased use of healthcare resources, and result in the inability to carry out the tasks of daily living. The purpose of this quantitative, correlational study was to investigate the potential influence of laughter on affect and pain in individuals with FMS. Laughter produces beneficial effects on acute pain and on chronic pain in general and has been found to improve temporary affective states, but there have been no studies testing the effects of laughter on the …

Potential Mediators Between Fibromyalgia And C-Reactive Protein: Results From A Large U.S. Community Survey., Termeh Feinberg, Usha Sambamoorthi, Christa Lilly, Kim Karen Innes

Clinical and Translational Science Institute

Background: Fibromyalgia, a potentially debilitating chronic pain syndrome of unknown etiology, may be characterized by inflammation. In this study, we investigated the relation of FMS to serum C-reactive protein (CRP) in a large population of adults (18+) and investigated the influence of other factors on this relationship, including BMI, comorbidities, as well as mood and sleep disturbance. Methods: Participants were 52,535 Ohio Valley residents (Fibromyalgia n = 1125). All participants completed a comprehensive health survey (2005–2006) part of the C8 Health Project; serum levels of CRP were obtained, as was history of Fibromyalgia physician diagnosis. Logistic and linear regressions were …

Pain Management In Patients With Fibromyalgia, Linsey Fischer

Honors Undergraduate Theses

Fibromyalgia is a chronic widespread pain disorder that can also cause fatigue, depression, sleep disturbances, and cognitive symptoms. Because the etiology of fibromyalgia is unknown, it is difficult to treat. Research shows that medication alone is insufficient to treat the symptoms of fibromyalgia and that complementary therapies are required to fully manage this disorder. The purpose of this research was to determine what complementary therapies patients with fibromyalgia were currently using. The sample for the survey was taken from fibromyalgia support groups throughout the state of Florida. A total of 15 people diagnosed with fibromyalgia participated in the survey. The …

Does Fibromyalgia Have An Effect On Hearing Loss In Women?, Zeli̇ha Kapusuz Gencer, Özlem Balbaloğlu, Mahmut Özkiriş, Levent Saydam

Turkish Journal of Medical Sciences

Background/aim: Fibromyalgia (FM) patients may have several neuroendocrine dysfunctions, resulting in a hypervigilant sensory output that may be responsible for sensorineural complaints. In this study, we evaluated the audiological findings of a cohort of female fibromyalgia patients. Materials and methods: Between 1 September 2012 and 1 June 2013, 35 female FM patients, followed by the Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Bozok University, were recruited for the study. The patients were referred to the Department of Otolaryngology for routine otolaryngological and audiological evaluations. Age range was between 30 and 65 years, with a mean age of 48.10 …

Is Laser Therapy An Effective Alternative Treatment For Women With Fibromyalgia?, Michelle B. Astrove

PCOM Physician Assistant Studies Student Scholarship

OBJECTIVE: The objective of this selective EBM review is to determine whether or not, “Is the use of laser therapy an effective alternative treatment for women with fibromyalgia?”

STUDY DESIGN: Review of three English language primary studies, published between 2002 and 2013.

DATA SOURCES: Three randomized controlled trials (RCTs) were found using Cochrane Systematic Reviews. These studies analyzed the effectiveness of laser therapy in women with fibromyalgia.

OUTCOMES MEASURED: Main outcomes measured were improvement in pain, number of tender points, muscular spasm, skinfold tenderness, sleep disturbance, fatigue and morning stiffness measured by an ordinal likert scale, Pain and FM impact …

Diagnosing Fibromyalgia: Using A Diagnostic Screening Tool In Primary Care, Lilo Fink

Walden Dissertations and Doctoral Studies

Fibromyalgia (FMS) goes undiagnosed in as many as 3 out of 4 people who have the disease. Primary care providers (PCPs) are the first to evaluate patients; therefore, PCPs need to be able to recognize FMS, implement initial treatment, and refer for further consultation. The Fibromyalgia Diagnostic Screening Tool (FDST), a validated instrument to identify FMS, can improve the speed and accuracy of FMS diagnosis. The purpose of this project was to familiarize PCPS with the FDST, evaluate their receptiveness to the tool, and train them in its use. The Leventhal, Diefenbach, and Levanthal, common sense model of illness provided …

Efficacy Of Memantine In Treating Patients With Fibromyalgia, Sameen Khalid, Bashir A. Soomro, Zahida Mahmood

Pakistan Journal of Neurological Sciences (PJNS)

To evaluate the efficacy of Memantine as a therapeutic intervention for fibromyalgia. Methods: This clinical trial was conducted between October 2014 and December 2014. A total of 30 subjects with diagnosed fibromyalgia presenting to a private neurology clinic in Karachi, Pakistan were selected through purposive sampling technique. Adult patients belonging to both genders were included in the study. Patients were treated with incremental doses of Memantine. Data was analyzed using SPSS version 20 and associations were made using Chi square test with p-value of less than 0.05 taken as significant. Results: Out of 30 patients, 2 (6.7%) were males and …

Fibromyalgia Syndrome: Considerations For Dental Hygienists, Amber Walters, Susan L. Tolle, Gayle M. Mccombs

Dental Hygiene Faculty Publications

PURPOSE: Fibromyalgia syndrome (FMS) is a neurosensory disorder characterized by widespread musculoskeletal pain. Typically persistent fatigue, depression, limb stiffness, non-refreshing sleep and cognitive deficiencies are also experienced. Oral symptoms and pain are common, requiring adaptations in patient management strategies and treatment interventions. Appropriate dental hygiene care of patients suffering with this disorder is contingent upon an understanding of disease epidemiology, pathophysiology, clinical characteristics, oral signs and symptoms, as well as treatment approaches. With this information dental hygienists will be better prepared to provide appropriate and effective treatment to patients with FMS.

Is Yoga Effective In Reducing Fibromyalgia-­Related Symptoms In Women With Fibromyalgia?, Molly R. Beckmann

PCOM Physician Assistant Studies Student Scholarship

Objective: The objective of this selective EBM review is to determine whether or not yoga is effective in reducing fibromyalgia-related symptoms in women with fibromyalgia.

Study Design: Review of two published double blind, randomized controlled trials published in 2010 and one before-after study published in 2012 were used for this review and selected based on their relevance to the clinical question

Data Source: Studies were found using PubMed, AMED, and CINAHL Plus.

Outcomes Measured: All three studies measured improvement of fibromyalgia symptoms based on a variety of well-validated measures, most notably the Fibromyalgia Impact Questionnaire, the Quality of Life Profile …

Relationship Between Adverse Childhood Experiences And Illness Perceptions Among Individuals With Fibromyalgia, Susan D. Fay

Walden Dissertations and Doctoral Studies

Relationship between Adverse Childhood Experiences and Illness Perceptions among Individuals with Fibromyalgia

by

Susan D. Fay

MS, Drexel University, 1994

BS, Metropolitan State University of Denver, 1983

Dissertation Submitted in Partial Fulfillment

of the Requirements for the Degree of

Doctor of Philosophy

Psychology

Walden University

February 2015

Adverse childhood experiences (ACEs), including abuse and neglect, are a significant social health problem. Exposure to ACEs can place a child at a high risk for developing different diseases or illnesses in adulthood, including fibromyalgia. The purpose of this study was to determine if exposure to ACEs, moderated by perceived social support and/or …