Medicine and Health Sciences Commons^™

Mapping Burdens And Inequalities Of Polycystic Ovary Syndrome In Young Females Across 953 Locations 1990–2040 With Deep Learning Forecasts, Yaling Wu, Wenxiang Cai, Mao Chen, Susu Luo, Robert J Norman, Mahnaz Bahri Khomami, Lisa Moran, Heping Zhang, Suhaniya N S Samarasinghe, Salman Rawaf, Davd A Ehrmann, Liming Pan, Kexin Ding, Shuxian Ma, Lili Zheng, Xian Shao, You Zuo, Baozhen Huang, Fei Li, Mingyang Xue, Tongrui Shang, Guangyao Cai, Yuanyuan Chen, Ying Wang, Yutong Lu, Dong Wang, Yuanyuan Wan, Ningning Wu, Ciqing Lin, Wei Pan, Rui Zhang, Tingting Yao, Yiming Xiong, Kai Chen, Jianli Zhao, Shunrong Li, Liling Zhu, Luyuan Tan, Yinduo Zeng, You Zeng, Lukasz Szarpak, Nadia M Hamdy, Claire Chenwen Zhong, Fa Yuan, Yihang Chu, Xiao Jia, Peng Wu, Linjiang Wei, Yanfang Ye, João Conde, Zimeng Wu, Jinjin Zhang, Yamei Tang, Pengpeng Ye, Dongzi Yang, Shixuan Wang, Azeem Majeed, Helena Teede, Wenyi Jin, Queran Lin

Faculty, Staff and Students Publications

Polycystic ovary syndrome (PCOS) is the most common reproductive endocrine disorder impacting the health of young female populations. Using harmonized estimates from 953 locations, we assessed temporal trends, geographic inequalities, and forecasts of PCOS among individuals aged 10-24 years from 1990 to 2040. Between 1990 and 2021, global prevalence and disability burden increased by more than 30%, with the highest burden observed among those aged 20-24 years. Substantial geographic heterogeneity was identified, with particularly high prevalence in Europe and East Asia. While high-income regions carried the greatest absolute burden, low- and middle-income regions showed the fastest growth, accompanied by widening …

Vascular Burden Attenuates The Tdp-43-Tmem106b Pathological Relationship In Neurodegenerative Disease With And Without Alzheimer Disease Neuropathological Change, Matthew B. Dopler, Cole Corbett, Angelique D. Gonzalez, Ali Ghaseminejad-Bandpey, Mallory Keating, Kyra M. Clarke, Oluwaseun B. Ogunbona, Gladys Maestre, Sudha Seshadri, Shahroo Etemadmoghadam, Margaret E. Flanagan

School of Medicine Publications

TMEM106B, a lysosomal transmembrane protein, is a risk factor for neurodegenerative diseases, including Alzheimer disease (ad) and TDP-43 proteinopathies. TMEM106B pathology occurs in normal aging and is increased in TDP-43 proteinopathy but its role in dementia remains unclear. Cerebrovascular disease (CVD) is a driver and co-pathology of dementia, yet its contribution to TMEM106B accumulation in the context of TDP-43 and ad neuropathological changes (ADNC) has not been explored. We analyzed post-mortem human hippocampal sections spanning not-, low-, intermediate-, and high-ADNC. In secondary analyses, cases ≥65 years were stratified by TDP-43 immunopositivity and CVD severity; cases < 65 years were included to contextualize age-associated effects. TMEM106B immunoreactivity was quantified using digital pathology. Linear regression models demonstrated that age and sex (higher in females) were independent predictors of TMEM106B immunopositivity whereas Braak stage, CERAD-NP score, and Thal phase were not. The positive TDP-43-TMEM106B association was attenuated with increased CVD pathology severity, suggesting that vascular burden modifies this relationship. Sensitivity analyses restricted to LATE-NC attenuated several associations, indicating that pooled TDP-43 findings should be interpreted cautiously given possible disease heterogeneity. TMEM106B immunoreactivity was most strongly associated with age and sex, while vascular burden, rather than ADNC level, modified its relationship with TDP-43 proteinopathy.

Potential Applications Of Thymus Vulgaris In Dental Care: A Review Of Antimicrobial And Oral Health Benefits, Lakenzia Z. Ham

Undergraduate Research Conference

This research proposal focuses on how common thyme (Thymus vulgaris) can be used in dental care. There has been more interest in natural products for dental health because some common dental treatments can have side effects or lead to antibiotic resistance. Thyme contains natural compounds like thymol and carvacrol that help kill bacteria, reduce inflammation, and prevent buildup on teeth.

The purpose of this study is to investigate the current scientific literature to see the effectiveness of thyme in preventing common oral health problems like cavities, gum disease, and bad breath. Research shows that thyme can fight bacteria …

The Social Determinants Of Health And Cancer, Joshua Williams

Ex Sapientia Loqui

The social determinants of health, as defined by the World Health Organization (WHO), are “the conditions in which people are born, grow, live, work and age, and people’s access to power, money and resources.” Epidemiologists have long studied the nexus between social forces and disease and have widely agreed that such forces are directly causal of pathologies. This paper is an analytic review of the existing literature on several social determinants— namely socioeconomic status (SES), race and ethnicity, age, working and living conditions, and social integration— and how they pertain to the causation, progression, and treatment of cancer.

Galen Of Pergamum: Life, Literature, And Legacy, Elyse Rogers

Ex Sapientia Loqui

Galen of Pergamum was a second-century physician whose work had an enduring impact on the field of medicine. His extensive writings were the primary reference and teaching materials for the medical community for over a millennium. While his ideas were revolutionary for his time, they were eventually outdated. Nevertheless, there was a continued reliance on his authority, which hindered scientific advancement. Galen both advanced the world of medicine with his emphasis on observational analysis and constrained its progress through the profound dominance of his theories.

This paper aims to understand the life of Galen and the significance of his work …

Assessing The Aesthetic Responsiveness Among Patients In A Free Clinic Setting, Jack E. Pitts

Student Scholar Showcase

Art therapy has increasingly been recognized as a complementary intervention in healthcare settings, with demonstrated benefits for stress reduction and overall biopsychosocial well-being. However, limited research has explored aesthetic engagement within medically underserved and economically disadvantaged populations. This study examines aesthetic responsiveness among patients receiving care at the Free Clinic of Central Virginia using a standardized Aesthetic Responsiveness Assessment. The assessment consists of 14 Likert-scale questions assessing individuals’ cumulative aptitude across three domains: aesthetic appreciation, intense aesthetic experience, and creative behavior. Responses and data were collected voluntarily and anonymously, and they were analyzed to better understand how patients in an …

The Impact Of Customized Alarm Sounds On Reducing Alarm Fatigue In Icu Nurses, Abigail L. Kendrick, Elizabeth G. Dunkum, Carly F. Harris

Student Scholar Showcase

Within hospital care, particularly in intensive care units, alarm fatigue poses a major threat to patient safety. As a result of the constant sound of alarms, nurses become desensitized and overstimulated in the health care setting. Patient safety is threatened by an increased risk of errors in care, which may lead to complications and poor health outcomes. By systematically reviewing various research studies within the time span of 2020-2025 regarding interventions to decrease the relevance of alarm fatigue, research suggests that there are methods that can be applied via numerous approaches. By customizing alarm sounds by severity, it is believed …

Nitrous Oxide Use In Labor, Aimee Aberson, Janae Cam, Rylie Franken, Rachel Henriksen, Ben Robinson, Pam Hulstein

Celebration of Research

Effective pain management during labor is a critical part of maternal care. It influences the mother’s physical and emotional experiences of childbirth. Epidural anesthesia and intravenous opioids are commonly used as analgesia in laboring mothers, but nitrous oxide (N₂O) has proven to be a safe, noninvasive alternative. It allows mothers to maintain mobility and consciousness while still reducing some pain perception. The purpose of this evidence-based practice project is to evaluate the effectiveness, safety, and satisfaction associated with N₂O use during active maternal labor. It reviews current literature on N₂O use during labor, focusing on maternal and neonatal safety, effectiveness …

Role Of Dental Screening In Preventing Hip Prosthetic Joint Infections, Aidan Anderson, Cailee Dix, Emma Franken, Erin Keizer, Zavyr Metzger, Tyra Snyder, Pam Hulstein

Celebration of Research

Hip arthroplasty is a common procedure, but Periprosthetic joint infection (PJI) remains a serious postoperative complication associated with increased hospital stays, readmissions, and costs. Evidence suggests that poor oral health may contribute to PJIs through the spread of bacteria from the mouth to the surgical site. This project examined the relationship between preoperative dental health and postoperative outcomes in adults aged 50–90 undergoing hip replacement. A literature review using the Johns Hopkins Research Evidence Appraisal Tool evaluated 19 studies from databases such as PubMed and ScienceDirect. While no clear association was found between specific dental risk factors and PJIs, untreated …

Understanding The Role Of Lipid Metabolism On Pancreatic Cancer Metastasis, Luke Fischer, Kylie Foss, Jacob Lewis, Joshua Lewis, Emma Steinhardt, Megan Vangarven, Cody Rozeveld

Celebration of Research

Pancreatic cancer is one of the deadliest types of cancer due to late-stage detection and early metastasis. Other than smoking, one of the few known risk factors for pancreatic cancer is obesity (1). On the cellular level, excess fat can promote cell migration and invasion (2). However, the exact fat utilization pathway remains unknown. We propose that lysosomes may be exploited in pancreatic cancer to break down fat and provide energy for metastasis and invasion.

Quantifying And Validating The Decrease Of Ciliogenesis Genes In Mouse Models With Pcd, Mia X. Kellenberger, Casey Mckenzie, Lance Lee

Celebration of Research

Primary ciliary dyskinesia (PCD) is a rare genetic disease affecting one in 16,000 children and results from structural or functional defects of motile cilia1. Lack of functioning cilia may result in reduced respiratory function, subfertility or infertility, and hydrocephalus due to a reduced ability to clear fluids and particles. A cilium consists of nine microtubules centered around a central pair complex1. Mutations in genes Spef2 (bgh), Cfap221 (nm1054), or Cfap54(Cfap54gt/gt), which encode proteins located in the central pair complex, result in PCD2,3,4. We previously utilized single-cell RNA sequencing to identify differentially expressed genes (DEGs) in early and late deuterosomal cells, …

Inpatient Treatment Compared To Outpatient Treatment For Borderline Personality Disorder, Paige Auch, Jaylin Gaston, Jori Harskamp, Ella Peterson, Kenzie Vonrentzell, Pam Hulstein

Celebration of Research

Borderline personality disorder (BPD) is a complex mental illness characterized by emotional instability, impulsivity, and unstable relationships. Individuals with BPD often require frequent hospitalizations and experience significant functional impairment. With increasing BPD admissions, Spencer Hospital seeks evidence-based strategies to improve patient outcomes and reduce readmissions. A literature review of ten studies (2016-2025) was conducted using PubMed, CINAHL, and Science Direct, appraised with the Johns Hopkins Nursing Evidence-Based Practice Model to compare inpatient and outpatient treatments for adults with BPD, focusing on symptom manage and quality of life. Findings indicate inpatient care with specific programs such as dialectical behavior therapy (DBT), …

Gut Health Interventions On Major Depressive Disorder, Hannah Beckloff, Ellie Erickson, Olga Furmanova, Hailey Van Dyken, Ashtyn Wobig

Celebration of Research

This evidence-based project aims to evaluate the potential benefits of probiotics, stress management, and a healthy diet for adults diagnosed with major depressive disorder at Promise Community Health Center. Through a comprehensive review of the literature, the project examines how interventions related to gut health can help alleviate depressive symptoms and implements the necessary tools to support this population at Promise. Our research findings suggest that combining probiotics, stress relief, and diet changes, along with adjunctive treatment for major depressive disorder, may reduce depressive symptoms and encourage a more holistic lifestyle for these individuals.

Subarachnoid Hemorrhage In A 46-Year-Old Male Firefighter With Full Return To Duty: Level 4 Rare Events Clinical Case Report., Elizabeth A. Mohnkern, Thomas Bowman, John R. Wise, Wendy Wilcoxson

Student Scholar Showcase

A 46-year-old physically active male firefighter suffered a spontaneous subarachnoid hemorrhage (SAH) in February 2023. He had no pertinent predisposing past medical history; occupation was the only predisposing factor. The patient described having a splitting headache behind the right eye, nausea, vomiting, chest pain, paralysis of his left side, faded vision, and a lapse of memory during the incident. During his first screening, he had difficulty with concentration, immediate memory, delayed recall, reading aloud, following directions, and balance. Cranial nerve assessments were within normal limits. The upper quarter screen revealed deficits in motor function from C4 through T1 nerve roots, …

Outcome And Clinical Characteristics Of Diaphragm Dysfunction After Pediatric Cardiac Surgery: From Detection To Plication, Muhammad Shahzad, Muhammad Bokir, Haifa Almuhanna, Abdulaziz Alanazi, Zehra Alabbas, Reem Beheri, Yasser Abdulrhman Alheraish, Khaled Alarwan

Journal of the Saudi Heart Association

Background:

Diaphragm paralysis (DP) due to phrenic nerve injury is a rare but serious complication of pediatric cardiac surgery (0.3–5% of cases). It presents as an extubation failure or difficulty weaning from ventilation. Early recognition and management are essential.

Objectives:

This study aimed to evaluate the incidence, clinical characteristic and outcome of diaphragm paralysis after heart surgery in children.

Methods:

A retrospective single-center review (2019–2024) was conducted of ultrasound-confirmed DP case. Demographics, surgical details, ventilatory course, interventions, and outcomes were analyzed. Partial and complete DP were compared using multivariate logistic regression to identify predictors.

Results:

Out of 2,280 surgeries, 108 …

Understanding How Nurses Could Utilize Child Life Specialists, Paige Perkins

Honors Projects

Do pediatric nurses notice improvement in patient education levels when they use the resources of Child Life Specialists, understand their role, and utilize their resources to educate their patients, compared to hospitals without Child Life Specialists?

Highway To Help: Increasing Access To Mental Health Occupational Therapy, Abbigail Hill

OTD Capstone Projects

This doctoral capstone project was completed in collaboration with the Tennessee Occupational Therapy Association (TNOTA) specifically TNOTA’s mental health chair. TNOTA’s mission is to “advance Occupational Therapy in Tennessee through education, advocacy, communication, and legislative involvement to support the provision of high-quality occupational therapy services and promote the benefits of our profession to consumers, stakeholders, and legislators in Tennessee (TNOTA, 2026). The project focused on increasing awareness of the benefits of occupational therapists in mental health settings as well as providing education for occupational therapists to increase knowledge of how to treat clients experiencing mental health challenges. This was achieved …

Developing Pediatric Educational Resources For Occupational Therapy Fieldwork Students And New Employees, Alyssa Gottheiner

Entry-Level Occupational Therapy Doctorate - Doctoral Capstone Symposium

For occupational therapy students, the fieldwork education portion of their curriculum allows them to apply theory and principles learned in their academic program into practice with actual clients (Occupational therapy fieldwork education, 2022). Research indicates the benefit of access to resources and adapting to different learning styles in occupational therapy fieldwork education (Grenier, 2015). Research also indicates that training programs for new healthcare employees can positively impact knowledge, skills, and performance (Patel et al., 2023).  However, there is a lack of research on the availability and benefit of supplemental educational resources for students to access during fieldwork education in pediatric …

Communication Culture: Visual Supports And Staff Education In Therapeutic Riding, Isabel R. Miller

Entry-Level Occupational Therapy Doctorate - Doctoral Capstone Symposium

Communication Culture: Visual Supports and Staff Education in Therapeutic Riding Equine-assisted therapy (EAS) has been shown to improve engagement, social interaction, and communication in individuals with autism and other developmental disabilities by creating natural, motivating opportunities for participation. A doctoral capstone project was completed in partnership with Charleston Area Therapeutic Riding (CATR) to utilize EAS alongside visual supports with the goal of increasing communication, engagement, sequencing and independence among student riders with diverse communication abilities. Deliverables included communication boards, PECS cards, visual schedules, and First-Then-Next boards to support task sequencing, communication and participation during therapeutic riding sessions. Staff education was …

Stronger Bodies, Sharper Minds: Promoting Wellness In Community-Dwelling Older Adults Through Exercise And Health Education, Michael Webb

Entry-Level Occupational Therapy Doctorate - Doctoral Capstone Symposium

Due to the increasing population of older adults, the need for health promotion and wellness-based interventions that support effective participation in their respective occupations is essential. Literature supports that engaging in physical activity, health education, and social participation are critical factors in increasing the quality and longevity of life among community-dwelling older adults. A doctoral capstone project was conducted at a community-based day program for low-income older adults to promote wellness, engagement, and continued participation in meaningful occupations.

The purpose of this project was to design and implement group sessions consisting of therapeutic exercise and health education to integrate education, …

Quality Improvement Project Strengthening Faculty Competence: The Impact Of Structured Debriefing Education On Nursing Faculty Confidence And Competency Compared To Current Practice, Sudaneyse Emmanuel

Doctor of Nursing Practice Projects

Nursing education sometimes struggles to prepare faculty to lead effective simulation-based learning and debriefing. Inconsistent debriefing practices can reduce faculty confidence and competency, limiting student reflection and the development of clinical judgment. This quality improvement project examined whether a structured debriefing education program could enhance nursing faculty confidence and competency in simulation debriefing compared with current practice at a technical college. The project used the Jeffries Simulation Theory and Lewin’s Change Theory as guides. The project used a one-group pretest-posttest design by using the C-Scale to measure confidence and the Facilitator Competency Rubric to measure competency among nursing faculty who …

Perceived Stigmatization Of Mental Health Problems And Utilization Of Academic Accommodations Among College Students, Sabrina Williams, Robert E. Davis Ph.D., Kristin Bogda Ph.D.

2026 Honors Symposium

Background: Higher education is seeing an increase in students utilizing mental health services. Studies on students with disabilities suggest students often have reservations about accessing these accommodations due to anticipated social stigmatization. Purpose: This study aimed to assess relationships among stigmatization and indicators of psychological distress among a sample of students who qualify for accommodations. Methods: This was a cross-sectional survey of students at a large university in the central United States. Data collection measures included previously validated screening instruments for depression, anxiety, suicidal ideation, and adapted versions of the validated scales to assess specific aspects of stigma related to …

Brain Delivery Of Antibody-Derived Biologicals For Alzheimer’S Disease: An Updated Narrative Review, Rachita K. Sumbria, Ruben J. Boado

Pharmacy Faculty Articles and Research

Antibodies directed against β-amyloid (Aβ) have been developed for the treatment of Alzheimer’s disease (AD). However, the in vivo central efficacy is reduced by the poor penetration of antibodies across the blood–brain barrier (BBB). In addition, these antibodies have been associated with adverse effects like amyloid-related imaging abnormalities. Thus, the development of new antibody-based therapies for AD with improved transport across the BBB may improve efficacy and reduce adverse effects. Antibodies targeting the BBB transferrin receptor (TfR) are able to cross the BBB through receptor-mediated transcytosis, producing a global distribution throughout the brain. Along the same line, bispecific antibodies directed …

Moving With Purpose: Promoting Occupational Therapy Through Inclusive Dance, Kymberli Reynolds

OTD Capstone Projects

This capstone project explored the role of occupational therapy in promoting participation and inclusion through adaptive dance at MOVE Inclusive Dance. The project focused on developing and implementing the mOTivate Movement initiative, which emphasized community outreach, education, and advocacy for individuals with diverse abilities. Interventions included leading adaptive dance classes, creating educational materials, and conducting a pre- and post-survey to assess staff's understanding of dance as a therapeutic occupation. Results indicated increased awareness of the therapeutic benefits of dance and the role of occupational therapy in inclusive settings. This project highlights the value of creative, occupation-based interventions in fostering social …

It's Your Turn To Turn, Barbara Alvarez Adn, Rn, Jessica Murante Bsn, Rn, Lisandra Nunez Adn, Rn, Felix Reinoso, Mauricio Teles Corte Adn, Rn

Vizient/ AACN Nurse Residency Program™ EBP Projects

No abstract provided.

Proclamation By The Governor Of Alabama: Year Of The Nurse, Robert Bentley

Documents

In 2015, Alabama Governor Robert Bentley declared the "year of the nurse" in honor of the "100 years of regulatory excellence" since the establishment of the Alabama Board of Nursing in 1915.

Invitation To The Open House At The New Education-Nursing Building, University Of North Alabama

Documents

Invitation to the open house at the Education and Nursing Building on Circular Road, now known as Stevens Hall

Whitlock Retiring As Nursing Professor, Melissa Gray

Documents

Article depicting the career and retirement of University of North Alabama nursing professor, Annette Whitlock, in 1985.

Sedentary Behavior Modifies The Effect Of Balance Rehabilitation On Balance Discordance In Parkinson’S Disease, Franziska Albrecht, Sarah J. Conklin, Andrew Hooyman, Daniel S. Peterson, Jason K. Longhurst, Erika Franzén

Physical Therapy Faculty Articles and Research

Individuals with Parkinson’s disease (PD) often experience a misalignment between their perceived and actual balance ability, known as balance discordance, which has been associated with falls. We examined whether high-intensity balance and gait training (HiBalance) alters balance discordance in individuals with PD, and whether baseline sedentary behavior influences these changes. A secondary analysis examining pre- to post-intervention discordance changes of two HiBalance clinical trials (N = 97) using linear regression with interactions between sedentary behavior and pre-intervention discordance. The sample included two cohorts: one clinical and one research based. The model including sedentary behavior and its interaction with pre-intervention …

Psychometric Properties Of Ecological Momentary Assessment Of Psychosocial Functioning In Adults With Complications Related To Type 1 Diabetes, Hayley Centola, Melissa Plegue, Dana Albright, Kara Mizokami-Stout, Lynn Ang, Jennifer Iyengar, Emily Hirschfield, Anna Kratz, Evan L. Reynolds, Brian C. Callaghan, Rodica Pop-Busui, Joyce M. Lee

Health Services and Informatics Research

Objectives: Ecological Momentary Assessment (EMA) is a promising methodology for examining the contextual impact of psychosocial functioning on chronic disease management in individuals with type 1 diabetes (T1D). Little is known regarding psychometric properties of EMA of psychosocial functioning in adults with complications related to T1D. The aim of this study is to explore the feasibility, reliability, and validity of EMA psychosocial measures examining depression, anxiety, diabetes-related distress, and fear of hypoglycemia in a sample of adult individuals with complications related to T1D.

Methods: Fifty-one participants with T1D completed a 14-day EMA of symptoms of depression, anxiety, diabetes-related distress, and …