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Articles 6421 - 6450 of 15653
Full-Text Articles in Medicine and Health Sciences
Quality Improvement Project Ai-Powered Conversations: Enhancing Nursing Students’ Interview Skills, Judy K. Staley
Quality Improvement Project Ai-Powered Conversations: Enhancing Nursing Students’ Interview Skills, Judy K. Staley
Doctor of Nursing Practice Projects
Professional communication is an essential skill for nursing students, particularly in job interviews. Deficits in professional communication can negatively impact future employment and accreditation outcomes. Current practices in faculty-led mock interviews can be limited by time constraints and the need for consistent feedback, underscoring the need for a more consistent and effective method supported by current evidence-based literature. The purpose of this quality improvement project is to evaluate whether integrating AI-assisted mock interviews into faculty-led practices influences faculty perceptions of student preparedness. Guided by Kotter’s Change Model and supported by the constructivist framework, the project aimed to enhance the effectiveness …
Thinking With The Feet In The Clinic Of Psychosis, Jed Wilson
Thinking With The Feet In The Clinic Of Psychosis, Jed Wilson
Middle Voices
In his later work, Lacan makes occasional reference to the idea of “thinking with the feet.” An equivocal formulation, it first seems to suggest that thought and language can be regarded as physical processes—not occurring in some homunculan disembodied brain or mind, but in the real of the body. Equally, it can call to mind the idea of thinking “on” one’s feet, in the manner of adaptive improvisation. Going further, could we not also say that it points to the possibility of setting something in motion (as in walking, dancing, going somewhere—all the things we do with the feet) as …
New Nurse Faculty Mentorship: A Quality Improvement Project, Kimberly B. Porter
New Nurse Faculty Mentorship: A Quality Improvement Project, Kimberly B. Porter
Doctor of Nursing Practice Projects
The ongoing nursing faculty shortage limits program capacity and makes it harder to retain novice nurse educators transitioning from clinical practice to academia. The literature highlights issues such as insufficient mentorship, role confusion, and a lack of structured support as key factors contributing to early faculty attrition. This quality improvement (QI) project aimed to implement and evaluate an evidence-based mentorship program to improve perceptions of mentorship effectiveness among new-to-academia nurse faculty in a School of Nursing in Arkansas. The purpose was to implement and evaluate a mentorship program designed to improve perceptions of mentorship among new-to-academia nurse faculty. The project …
Quality Improvement Project: Impacting Staff Confidence In Recognizing Hiv Medication Adherence, Joy Nwansi-Iro
Quality Improvement Project: Impacting Staff Confidence In Recognizing Hiv Medication Adherence, Joy Nwansi-Iro
Doctor of Nursing Practice Projects
Medication adherence to antiretroviral therapy is essential for viral suppression and improved outcomes among individuals living with human immunodeficiency virus (HIV). Despite advances in treatment, healthcare providers lack confidence in recognizing medication adherence challenges and implementing appropriate interventions. Evidence suggests that provider education using standardized adherence assessment tools improves adherence monitoring and clinical decision-making. The purpose of this quality improvement project is to evaluate whether an educational intervention and a standardized workflow using the CASE Adherence Index would impact healthcare staff confidence in recognizing HIV medication adherence. Lewin’s Change Theory guided the project through the stages of unfreezing, change, and …
Quality Improvement Project: Enhancing Staff Delivery Of Non-Pharmacological Interventions In Serious Mental Illness Care, Kimberly Vann
Quality Improvement Project: Enhancing Staff Delivery Of Non-Pharmacological Interventions In Serious Mental Illness Care, Kimberly Vann
Doctor of Nursing Practice Projects
Serious mental illness places a significant burden on global healthcare systems, increasing hospital utilization and critically impairing patients' functional status. Often crippling, these illnesses are mostly treated with medication therapy despite proven research to show effective outcomes with holistic and non-pharmacological therapies. Non-pharmacological interventions (NPIs) are often underutilized in outpatient mental health settings. The purpose of this quality improvement project was to determine whether structured training impacted staff confidence in delivering NPIs and impacted documentation frequency in the electronic health record (EHR). The project was guided by the Iowa Model of Evidence-Based Practice and implemented using the Plan-Do-Study-Act (PDSA) cycle, …
Quality Improvement Project Bridging The Gap In Scholarly Productivity: An Educational Workshop For Tenure-Track Nursing Faculty, Britney Thorne
Quality Improvement Project Bridging The Gap In Scholarly Productivity: An Educational Workshop For Tenure-Track Nursing Faculty, Britney Thorne
Doctor of Nursing Practice Projects
Tenure-track nursing faculty often balance teaching, service, and scholarship responsibilities, which can be overwhelming when promotion and tenure expectations are unclear or insufficiently supported. At a historically Black university, a school of nursing identified gaps in scholarly productivity and limited guidance for early-career faculty, highlighting the need for structured support. Guided by Knowles’ Adult Learning Theory and Lewin’s Change Theory, this Doctor of Nursing Practice (DNP) quality improvement project examined whether structured faculty development workshops could improve faculty knowledge of scholarly productivity, engagement in scholarly activities, and perceptions of tenure and promotion expectations. A quasi-experimental pre-post design was implemented over …
Enhancing Ot-Classroom Staff Collaboration: A Usability Study Of A Formalized Sensory Communication Process, Victoria Foo, Neil Harvison, Alyson Pasquale, George Bulger, Jessica Evans
Enhancing Ot-Classroom Staff Collaboration: A Usability Study Of A Formalized Sensory Communication Process, Victoria Foo, Neil Harvison, Alyson Pasquale, George Bulger, Jessica Evans
Post Professional Occupational Therapy Doctoral (PPOTD) Student Capstone Projects
Addressing students’ sensory-based behaviors can be challenging when there are no team-based and student-centered approaches in place, making it essential to create an interdisciplinary framework where OTs and classroom staff communicate consistently to blend supports. Effective communication and collaboration involve carryover, explanation, education, and training of sensory processing and sensory-based interventions (SBI) as crucial components in a knowledge translation process.
Assessing The Feasibility Of Integrating Occupational Therapy Services Within A Pediatric Primary Care Setting For Children 0-3 Years Old., Amanda L. Wilbert, Cristina Dumitrescu, Kim Karr
Assessing The Feasibility Of Integrating Occupational Therapy Services Within A Pediatric Primary Care Setting For Children 0-3 Years Old., Amanda L. Wilbert, Cristina Dumitrescu, Kim Karr
Post Professional Occupational Therapy Doctoral (PPOTD) Student Capstone Projects
The objective of this capstone project was to assess the feasibility of implementing occupational therapy (OT) services within a pediatric primary care office using a manualized service delivery approach. Occupational therapy is inherently grounded in parent coaching and education, positioning the profession to play a critical role in supporting families and promoting early identification of developmental risk. This project aimed to address a documented gap in the inclusion of OT within pediatric primary care by exploring how OT services can support parenting skills and monitor children identified as at risk for developmental, behavioral, or psychosocial concerns. The project was conducted …
Associations Between Smoking Habits And Weight-Related Behaviors Among People Who Smoke In The United Arab Emirates: A Cross-Sectional Study, Sharifa Alblooshi, Maryam Hassan Dawood, Dana N. Abdelrahim, Marika Lo Monaco, Falak Zeb
Associations Between Smoking Habits And Weight-Related Behaviors Among People Who Smoke In The United Arab Emirates: A Cross-Sectional Study, Sharifa Alblooshi, Maryam Hassan Dawood, Dana N. Abdelrahim, Marika Lo Monaco, Falak Zeb
All Works
Background: Smoking is one of the leading global public health problems, and is complicated by multiple reasons for its prevalence and associated health problems. An understanding of the influence of smoking activity on weight management is essential to formulate successful health programs. Aim: The objective of the present study was the investigation of the association between smoking habits and weight management among adult people who smoke in the UAE. Methods: A cross-sectional study was conducted with 232 participants who completed a 36-item questionnaire assessing their smoking habits and weight management practices. Results: The sample consisted mostly of males (75.4%) aged …
Outcomes Of Deep Peroneal Neurectomy: A Scoping Review Of Complications, Postoperative Recovery, And Patient-Reported Satisfaction, Krista Elizabeth Samreth, James Hughes, Amayrani Sanchez, Nicholas Obias, Madeleine Mehaffey, Stephanie Campbell Dpm, Aacfas
Outcomes Of Deep Peroneal Neurectomy: A Scoping Review Of Complications, Postoperative Recovery, And Patient-Reported Satisfaction, Krista Elizabeth Samreth, James Hughes, Amayrani Sanchez, Nicholas Obias, Madeleine Mehaffey, Stephanie Campbell Dpm, Aacfas
School of Podiatric Medicine - Student Research
Background: Deep peroneal neurectomy (DPN) evolved as a surgical treatment alternative for patients with painful midfoot arthritis who may not tolerate more invasive surgery such as arthrodesis. This scoping review aims to display current evidence of postoperative recovery complications and patient-reported outcomes specific to alternative surgical treatment of DPN.
Methods: A scoping review was completed using PRISMA-ScR reporting standards. Investigators searched PubMed, Google Scholar, Foot & Ankle Orthopedics, and Journal of Foot and Ankle Surgery for studies from 2002 to 2025 with search terms: “deep peroneal neurectomy,” OR “deep peroneal nerve excision,” OR “peroneal neurectomies” AND “midfoot arthritis”. Exclusion criteria …
Prenatal Care Access And Pregnancy Outcomes Among Black Women Ages 15–44 In Cook County, Illinois, Deandrea Heggins
Prenatal Care Access And Pregnancy Outcomes Among Black Women Ages 15–44 In Cook County, Illinois, Deandrea Heggins
Walden Dissertations and Doctoral Studies
Maternal health disparities affecting Black women in the United States remain a persistent public health concern due to inequities in prenatal care access and adverse birth outcomes. Prior research has shown that socioeconomic conditions, insurance coverage, and systemic barriers influence prenatal care utilization and maternal outcomes; however, limited research has examined how Medicaid coverage, household income, preterm birth, and birth weight are collectively associated with prenatal care access among Black women in Cook County, Illinois. The purpose of this quantitative correlational study was to examine the relationships among these factors and access to prenatal care among Black women ages 15–44 …
High Concordance Of Physician-Attestation With Manual Data Abstraction For Sickle Cell Type: An Ash Rc Data Hub Study, Alexis Thompson, Ashima Singh, Donna Neuberg, Amanda Brandow, Allison King, Sophie Lanzkron, Emily Semmel, Sam Walters, Susan Rogers, Kathleen Torres, William Wood
High Concordance Of Physician-Attestation With Manual Data Abstraction For Sickle Cell Type: An Ash Rc Data Hub Study, Alexis Thompson, Ashima Singh, Donna Neuberg, Amanda Brandow, Allison King, Sophie Lanzkron, Emily Semmel, Sam Walters, Susan Rogers, Kathleen Torres, William Wood
Cardeza Foundation for Hematologic Research
Sickle cell disease (SCD) is the most common inherited blood disorder in the United States. The American Society of Hematology Research Collaborative (ASH RC) has built an SCD Data Hub (DH) to facilitate research and quality improvement using real-world data. To our knowledge, we report here the first analyses from the DH, focusing on cohort demographics and accurate identification of SCD diagnosis type. DH sites have data use agreements with ASH RC to extract and transfer electronic health record (EHR) data at least quarterly. Principal investigators (PI) provided additional attestation of SCD diagnosis based on existing local data sources deemed …
Cross-Sectional Associations Of Metabolically Healthy Obesity, Lifestyle Factors, And Steatotic Liver Disease In Adults From The Fels Longitudinal Study, Ariana L Garza, Audrey C Choh, John Blangero, Cici X Bauer, Stefan A Czerwinski, Miryoung Lee
Cross-Sectional Associations Of Metabolically Healthy Obesity, Lifestyle Factors, And Steatotic Liver Disease In Adults From The Fels Longitudinal Study, Ariana L Garza, Audrey C Choh, John Blangero, Cici X Bauer, Stefan A Czerwinski, Miryoung Lee
Faculty, Staff and Student Publications
Objective: To examine the associations of metabolic health and obesity phenotypes with liver fat accumulation and hepatic steatosis in adults.
Methods: We analyzed 676 non-Hispanic white adults (18-95 years; 55.8% female) from the Fels Longitudinal Study using a cross-sectional design. Participants were classified into metabolically healthy normal weight (MHNW), metabolically healthy obesity (MHO), metabolically unhealthy normal weight (MUNW), and metabolically unhealthy obesity (MUO) phenotypes. Metabolically unhealthy status was defined as the presence of ≥1 metabolic dysfunction, consistent with prior epidemiological definitions; secondary analyses using ≥2 were also performed. Obesity was defined using DXA-derived body fat percentage. Liver fat (%) was …
Serum Metabolites Associated With Depression And Anxiety In The Hispanic Community Health Study/Study Of Latinos, Xinye Qiu, Yu Zhang, Yogesh Purushotham, Qibin Qi, Bing Yu, Jan Bressler, Krista M Perreira, Humberto Parada, Martha L Daviglus, Alejandra Cid Vega, Carmen R Isasi, Linda C Gallo, Tamar Sofer
Serum Metabolites Associated With Depression And Anxiety In The Hispanic Community Health Study/Study Of Latinos, Xinye Qiu, Yu Zhang, Yogesh Purushotham, Qibin Qi, Bing Yu, Jan Bressler, Krista M Perreira, Humberto Parada, Martha L Daviglus, Alejandra Cid Vega, Carmen R Isasi, Linda C Gallo, Tamar Sofer
Faculty, Staff and Student Publications
Omics signatures for psychiatric conditions have been under-investigated. In this study, we used data from a representative observational cohort study of Hispanic/Latino adults to identify serum metabolites associated with symptoms of depression or anxiety and to develop and assess metabolite risk scores (MRSs) of these phenotypes. We conducted a metabolome-wide association study of 768 metabolites with depression and anxiety symptoms, using two separate assay batches measured from baseline samples collected between June 2008 and July 2011 for discovery (batch 1: n = 4002 adults) and replication (batch 2: n = 2178 adults). We estimated the associations via survey-based generalized linear …
Executive Summary: Executive Leadership System Improvement Improving Depression Screening And Follow Up Processes, Rebecca Geneiveve Hidalgo Salomon
Executive Summary: Executive Leadership System Improvement Improving Depression Screening And Follow Up Processes, Rebecca Geneiveve Hidalgo Salomon
Walden Dissertations and Doctoral Studies
Depression remains a significant public health burden in the United States, contributing to disability, healthcare utilization, and economic cost. Internal 2024 audits at the project site identified variability in Patient Health Questionnaire 9 PHQ 9 screening and follow up processes, with 68% of screenings completed, 55% of follow ups timely, and disparities among patients with limited English proficiency. These findings indicate a systems level reliability and equity gap. This executive leadership system improvement project focused on developing a standardized, nurse led, electronic health record supported workflow to improve PHQ 9 completion and timely follow up. The practice focused question asked …
Comparative Analysis Of Rectal Dose In Two-Arc Versus Three-Arc Vmat Prostate Cancer Using Spaceoar, Amanda Bookout
Comparative Analysis Of Rectal Dose In Two-Arc Versus Three-Arc Vmat Prostate Cancer Using Spaceoar, Amanda Bookout
Masters Projects
Abstract
Purpose
The purpose of this study is to determine the dosimetric impact on rectal dose by comparing two arc versus three arc VMAT plans on prostate patients who have received SpaceOAR.
Methods
A retrospective planning technique was performed on eight prostate cancer patients who had been previously treated with three-arc VMAT plans. For each plan, a two-arc plan was generated by removing the third arc and re-optimizing the plans using identical constraints and objectives. Dosimetric parameters were analyzed using dose volume histogram (DVH) analysis, including rectal dose metrics, V60 Gy, V65 Gy, V70 Gy, target coverage, PTV V95%, conformity …
Risk Of Alzheimer Dementia After High-Dose Vs Standard-Dose Influenza Vaccination, Avram Samuel Bukhbinder, Yaobin Ling, Lauren Jhin, Elizabeth He, Kristofer Harris, Mya Rodriguez, Jenna Thomas, Gabriela Cruz, Kamal Phelps, Yejin Kim, Luyao Chen, Xiaoqian Jiang, Paul E Schulz
Risk Of Alzheimer Dementia After High-Dose Vs Standard-Dose Influenza Vaccination, Avram Samuel Bukhbinder, Yaobin Ling, Lauren Jhin, Elizabeth He, Kristofer Harris, Mya Rodriguez, Jenna Thomas, Gabriela Cruz, Kamal Phelps, Yejin Kim, Luyao Chen, Xiaoqian Jiang, Paul E Schulz
Faculty, Staff and Student Publications
Background and objectives: Previous studies, including large cohort analyses comparing vaccinated and unvaccinated adults, suggest that routine immunizations such as inactivated influenza vaccines (IIVs) may reduce Alzheimer dementia (AD) risk. Whether AD risk differs after high-dose IIV (H-IIV) vs standard-dose IIV (S-IIV) remains unexamined. We hypothesized that AD risk would be lower among adults ≥65 years after H-IIV compared with S-IIV.
Methods: This retrospective cohort study analyzed data spanning 2014-2019 from IQVIA PharMetrics Plus for Academics, a US health care claims database. Eligible participants were ≥65 years with ≥2 years of continuous medical and pharmaceutical coverage and no previous diagnostic …
Vestibular Schwannoma Microsurgery In The Era Of Multimodal Treatment: Advances In Technique And Patient Selection, Ibrahem Albalkhi, Basel Musmar, Nimer Adeeb, Hussam Abou-Al-Shaar, Jacques J Morcos
Vestibular Schwannoma Microsurgery In The Era Of Multimodal Treatment: Advances In Technique And Patient Selection, Ibrahem Albalkhi, Basel Musmar, Nimer Adeeb, Hussam Abou-Al-Shaar, Jacques J Morcos
Faculty, Staff and Student Publications
Background: The management of vestibular schwannoma (VS) has traditionally prioritized gross total resection to achieve high tumor control, often at the cost of cranial nerve injuries and quality of life impairment. However, advances in surgical approaches and intraoperative technologies, coupled with active surveillance and/or adjuvant treatment, have shifted the management paradigm towards prioritizing patient-centered outcomes, which are as critical as oncological control.
Content: The authors reviewed the technical advances driving this paradigm shift, including endoscopic assistance in the different microsurgical approaches (retrosigmoid, translabyrinthine, and middle cranial fossa approaches) of VS resection and advanced neuromonitoring (facial nerve electromyography and cochlear/auditory evoked …
A Novel Approach To Defining Progression In Mds And Precursor Myeloid Conditions In The Mds Natural History Study, Amy E Dezern, Matthew Walter, Et Al.
A Novel Approach To Defining Progression In Mds And Precursor Myeloid Conditions In The Mds Natural History Study, Amy E Dezern, Matthew Walter, Et Al.
2020-Current year OA Pubs
Patients at risk for progression from myeloid precursor states (idiopathic cytopenia of undetermined significance [ICUS] and clonal cytopenia of undetermined significance [CCUS]) to myelodysplastic syndrome (MDS) are not well defined. Epidemiologic risk factors, clonal changes for MDS development, and evolution from one MDS state to another were available in the MDS Natural History Study (NHS), a prospective cohort enrolled at diverse US sites. Extensive clinical data and biospecimens were collected at baseline and follow-up. A total of 1177 (56%) individuals with MDS or MDS-related precursor conditions (ICUS/idiopathic dysplasia of undetermined significance [IDUS], CCUS, and MDS/myeloproliferative neoplasm overlap) were enrolled and …
High Concordance Of Physician-Attestation With Manual Data Abstraction For Sickle Cell Type: An Ash Rc Data Hub Study, Alexis A Thompson, Ashima Singh, Donna S Neuberg, Amanda M Brandow, Allison A King, Sophie Lanzkron, Emily A Semmel, Sam Walters, Susan Rogers, Kathleen Torres, William A Wood
High Concordance Of Physician-Attestation With Manual Data Abstraction For Sickle Cell Type: An Ash Rc Data Hub Study, Alexis A Thompson, Ashima Singh, Donna S Neuberg, Amanda M Brandow, Allison A King, Sophie Lanzkron, Emily A Semmel, Sam Walters, Susan Rogers, Kathleen Torres, William A Wood
2020-Current year OA Pubs
Sickle cell disease (SCD) is the most common inherited blood disorder in the United States. The American Society of Hematology Research Collaborative (ASH RC) has built an SCD Data Hub (DH) to facilitate research and quality improvement using real-world data. To our knowledge, we report here the first analyses from the DH, focusing on cohort demographics and accurate identification of SCD diagnosis type. DH sites have data use agreements with ASH RC to extract and transfer electronic health record (EHR) data at least quarterly. Principal investigators (PI) provided additional attestation of SCD diagnosis based on existing local data sources deemed …
Microarray Analysis Of Human Abdominal Aortic Aneurysm With Emphasis On Cardiovascular Genes Revealed Differentially Expressed Genes, Song Lu, Li Ping Li, John V. White, Xiaoying Zhang, Ifeyinwa Nwaneshiudu, Adaobi Nwaneshiudu, Nectaria Ntaoula, John Gaughan, Dimitri S. Monos, Wan-Lu Lin, Charalambos C. Solomides, Emilia L. Oleszak, Chris D. Platsoucas
Microarray Analysis Of Human Abdominal Aortic Aneurysm With Emphasis On Cardiovascular Genes Revealed Differentially Expressed Genes, Song Lu, Li Ping Li, John V. White, Xiaoying Zhang, Ifeyinwa Nwaneshiudu, Adaobi Nwaneshiudu, Nectaria Ntaoula, John Gaughan, Dimitri S. Monos, Wan-Lu Lin, Charalambos C. Solomides, Emilia L. Oleszak, Chris D. Platsoucas
Department of Pathology, Anatomy, and Cell Biology Faculty Papers
BACKGROUND/AIM: We examined gene expression profiles in abdominal aortic aneurysm (AAA) lesions vs. normal aortas by cDNA microarray and real-time quantitative reverse-transcriptase polymerase chain reaction (qRT-PCR).
MATERIALS AND METHODS: Phosphorus (32P)-labeled cDNA from AAA specimens (mean AAA size 6.65 cm) and normal aortas were hybridized with a 588-gene microarray primarily of the cardiovascular system. The results were validated by qRT-PCR.
RESULTS: A total of 35 out of the 588 genes were differentially expressed, with either log2 ratio of AAAs/controls ≥1 (upregulated; 20 genes) or ≤-1 (downregulated; 15 genes) in AAA lesions vs. normal aorta, and …
Feasibility Of Nationwide Remote Chronic Neural Data Collection From Recording-Enabled Deep Brain Stimulation Systems, Kasra A Mansourian, Ajay D Gandhi, Jonathan H Bentley, Kalman A Katlowitz, Danika L Paulo, Nisha Giridharan, Mohammed A Hasen, Tommy B Liu, Zain U Naqvi, Sarah S Soubra, Thomas A Hamre, Rick R Hanish, Eric A Storch, Wayne K Goodman, Sameer A Sheth, Nicole R Provenza
Feasibility Of Nationwide Remote Chronic Neural Data Collection From Recording-Enabled Deep Brain Stimulation Systems, Kasra A Mansourian, Ajay D Gandhi, Jonathan H Bentley, Kalman A Katlowitz, Danika L Paulo, Nisha Giridharan, Mohammed A Hasen, Tommy B Liu, Zain U Naqvi, Sarah S Soubra, Thomas A Hamre, Rick R Hanish, Eric A Storch, Wayne K Goodman, Sameer A Sheth, Nicole R Provenza
Faculty, Staff and Students Publications
Introduction: Bidirectional deep brain stimulation (DBS) devices can continuously record neural activity while delivering stimulation. Due to memory limitations on the implanted device on which data are stored, frequent data downloads are required to prevent data loss. In this study, we present a novel collaborative data collection method utilizing a nationwide network of device representatives to allow frequent data transfer that reduces data loss without imposing travel burden on patients.
Methods: We collected chronic neural data from nine patients with severe obsessive-compulsive disorder who received ventral capsule/ventral striatum DBS treatment between May 2023 and August 2024. We included patients implanted …
Disordered Differentiation And Cellular Senescence In Pediatric Hodgkin Reed-Sternberg Cells, Jennifer E Agrusa, Elmoataz Abdel Fattah, Howard Lin, Jessica Velazquez, Sandra Andrea Salinas, Harshal A Abhyankar, Brooks P Scull, Ryan Fleischmann, M Tarek Elghetany, Andrea N Marcogliese, Choladda V Curry, Jyotinder N Punia, Nmazuo W Ozuah, Olive S Eckstein, Nader K El-Mallawany, Nitya Gulati, Joseph Lubega, Terzah M Horton, Kala Y Kamdar, Kenneth L Mcclain, Tsz-Kwong Man, Carl E Allen
Disordered Differentiation And Cellular Senescence In Pediatric Hodgkin Reed-Sternberg Cells, Jennifer E Agrusa, Elmoataz Abdel Fattah, Howard Lin, Jessica Velazquez, Sandra Andrea Salinas, Harshal A Abhyankar, Brooks P Scull, Ryan Fleischmann, M Tarek Elghetany, Andrea N Marcogliese, Choladda V Curry, Jyotinder N Punia, Nmazuo W Ozuah, Olive S Eckstein, Nader K El-Mallawany, Nitya Gulati, Joseph Lubega, Terzah M Horton, Kala Y Kamdar, Kenneth L Mcclain, Tsz-Kwong Man, Carl E Allen
Faculty, Staff and Students Publications
Hodgkin lymphoma (HL) is characterized by inflammatory lesions with relatively few (typically < 1%) pathogenic Hodgkin Reed-Sternberg (HRS) cells. The scarcity of malignant HRS cells in HL has historically limited characterization of these disease drivers, and pathogenic mechanisms underlying HL are incompletely defined. Using multiparameter flow cytometry to purify HRS cells and immune cell populations from pediatric HL lesions and control tonsils, we sought to define transcriptional programs in pediatric HRS cells. HRS cells are thought to arise from transformed germinal center B cells. Interestingly, transcriptomic analysis of HRS cells compared to control tonsil CD30+ cells revealed disordered differentiation with multilineage gene expression patterns, and primary HRS cells had distinct transcriptomes compared to HL cell lines. Further, transcriptomic analysis revealed increased expression of senescence-related genes and downregulation of proapoptotic/mitosis-related genes. Gene expression findings were validated by immunohistochemistry and single-cell imaging. In vitro treatment of primary HRS cells with B-cell lymphoma 2 inhibitor, venetoclax, augmented the induction of apoptosis in HRS cells and other cells of the HL immune microenvironment. These findings support the further study of targeting apoptosis resistance as a potential approach to eliminate malignant HRS cells and dismantle inflammatory lesion formation in pediatric HL.
Yap Induces A Prorenewal Metabolic State In Cardiomyocytes, Lin Liu, Jeffrey D Steimle, Chang-Ru Tsai, Fansen Meng, Yuka Morikawa, Yi Zhao, Sandra Carmichael, Xiao Li, James F Martin
Yap Induces A Prorenewal Metabolic State In Cardiomyocytes, Lin Liu, Jeffrey D Steimle, Chang-Ru Tsai, Fansen Meng, Yuka Morikawa, Yi Zhao, Sandra Carmichael, Xiao Li, James F Martin
Faculty, Staff and Students Publications
BACKGROUND: Cardiomyocytes, as highly specialized and differentiated somatic cells, possess a limited capacity for renewal. Neonatal rodents possess the ability to regenerate cardiomyocytes after injury; however, this regenerative capacity declines rapidly with cardiomyocyte maturation, suggesting an inhibitory network between cellular maturation and cardiomyocyte proliferation. Maturing cardiomyocytes undergo a metabolic shift from predominantly glycolysis in the neonatal state to increased fatty acid oxidation in the mature state, which poses a barrier to cardiomyocyte proliferation and cardiac regenerative repair. YAP, a transcriptional cofactor regulated by the Hippo signaling pathway, promotes cardiac regenerative repair. We investigated the role of YAP in mediating metabolic …
Familial Healthy Aging And Longevity: The Role Of Spouses, Søren Netra, Angéline Galvin, Matthew Keys, Katrine Lawaetz Kristensen, Jacob Krabbe Pedersen, Bharat Thyagarajan, Svetlana Ukraintseva, Mary K Wojczynski, Dorret I Boomsma, Kaare Christensen
Familial Healthy Aging And Longevity: The Role Of Spouses, Søren Netra, Angéline Galvin, Matthew Keys, Katrine Lawaetz Kristensen, Jacob Krabbe Pedersen, Bharat Thyagarajan, Svetlana Ukraintseva, Mary K Wojczynski, Dorret I Boomsma, Kaare Christensen
2020-Current year OA Pubs
BACKGROUND: Families with exceptional longevity often experience delayed onset of age-related diseases and reduced mortality across generations-a pattern influenced by shared genetic and behavioral factors. While several studies have focused on the members of longevity-enriched families (LEF), little is known about the health trajectories of the spouses marrying into these families. Given prior evidence of substantially reduced mortality among spouses of LEF members, determining whether this advantage reflects selection, shared environments, or behavioral convergence is essential for understanding the mechanisms that underlie intergenerational health transmission.
METHODS: We conducted a multigenerational, retrospective matched cohort study using nationwide Danish civil and health …
Percutaneous Coronary Intervention And Vascular Access Complications: A Contemporary Review, Tanawat Attachaipanich, Muzamil Khawaja, Edwin A Takahashi, Hafeez Ul Hassan Virk, Mahboob Alam, Ian C Gilchrist, Chayakrit Krittanawong
Percutaneous Coronary Intervention And Vascular Access Complications: A Contemporary Review, Tanawat Attachaipanich, Muzamil Khawaja, Edwin A Takahashi, Hafeez Ul Hassan Virk, Mahboob Alam, Ian C Gilchrist, Chayakrit Krittanawong
Faculty, Staff and Students Publications
Transradial approach (TRA) is preferred over transfemoral approach (TFA) for percutaneous coronary interventions due to lower bleeding, vascular complications, and mortality, particularly in acute coronary syndrome. Radial access complications included intraprocedural events (spasm, dissection, and perforation) and postprocedural events (radial artery occlusion, hematoma, pseudoaneurysm, arteriovenous fistula, nerve injury, and infection). TFA remains necessary in certain settings but carries higher complication risk. Optimizing patient selection and procedural planning is essential to minimize vascular complications.
Age-Associated Hematopoietic Variants In The Rhesus Macaque, Josephine De La Fuente, Chiraag D Kapadia, R Alan Harris, Muthuswamy Raveendran, Giovanne B Diniz, John H Morrison, Jeffrey Rogers, Margaret A Goodell
Age-Associated Hematopoietic Variants In The Rhesus Macaque, Josephine De La Fuente, Chiraag D Kapadia, R Alan Harris, Muthuswamy Raveendran, Giovanne B Diniz, John H Morrison, Jeffrey Rogers, Margaret A Goodell
Faculty, Staff and Students Publications
No abstract provided.
Beyond Symptoms: A Narrative Counseling Interpretation Of First-Year Student Anxiety In Indonesian Higher Education, Azizah Abdullah, Rizky Andana Pohan, Ramtia Darma Putri, Triyono Triyono, Marimbun Marimbun, Rahmi Dwi Febriani
Beyond Symptoms: A Narrative Counseling Interpretation Of First-Year Student Anxiety In Indonesian Higher Education, Azizah Abdullah, Rizky Andana Pohan, Ramtia Darma Putri, Triyono Triyono, Marimbun Marimbun, Rahmi Dwi Febriani
Buletin Konseling Inovatif
The transition to higher education is a critical period in which first-year students face new academic demands, financial pressures, social adjustment challenges, and uncertainty about the future. However, limited research has examined how freshmen make sense of and narrate their anxiety, particularly in the Indonesian context. This study aimed to explore the main domains of anxiety among first-semester students in Indonesian public universities and to interpret these experiences through a narrative counseling lens. The study employed a qualitative online survey design with an interpretivist orientation. Data were collected from 199 first-semester students through open-ended questions addressing anxiety-provoking situations, sources of …
Mitigation Of Race-Based Antihypertensive Prescribing, Victoria Scaccia Msn Rn Cnl Dnp, Bridget O'Brien Dnp, Stephanie Crane Md, Amanda Bradke Md
Mitigation Of Race-Based Antihypertensive Prescribing, Victoria Scaccia Msn Rn Cnl Dnp, Bridget O'Brien Dnp, Stephanie Crane Md, Amanda Bradke Md
North American Conference to End Race-Based Medicine
No abstract provided.
Six Steps To Squats: A Training Protocol To Guide Functional Rehabilitation Following Isolated Lower Extremity Fractures, Batoul Baydoun, Abdurrahman Ehsan, Manar Chebli, Zarrar Chauhdri, Ahmed Memon, Ahmad Almaat Bs, Omar Abdalla Bs, Haytham Alqasmi Bs, Ameen Suhrawardy Md, Rahul Vaidya Md
Six Steps To Squats: A Training Protocol To Guide Functional Rehabilitation Following Isolated Lower Extremity Fractures, Batoul Baydoun, Abdurrahman Ehsan, Manar Chebli, Zarrar Chauhdri, Ahmed Memon, Ahmad Almaat Bs, Omar Abdalla Bs, Haytham Alqasmi Bs, Ameen Suhrawardy Md, Rahul Vaidya Md
North American Conference to End Race-Based Medicine
No abstract provided.