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2026

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Articles 15271 - 15300 of 15430

Full-Text Articles in Medicine and Health Sciences

Gender Justice In The Triple Planetary Crisis: A Scoping Review, Catelyn Richards, Micah Peters, Julia Charalambous, Lila Singh-Peterson, Lucy Osborn, Aletha Ward, Jessica Leclair, Tracy Levett-Jones Jan 2026

Gender Justice In The Triple Planetary Crisis: A Scoping Review, Catelyn Richards, Micah Peters, Julia Charalambous, Lila Singh-Peterson, Lucy Osborn, Aletha Ward, Jessica Leclair, Tracy Levett-Jones

Research outputs 2022 to 2026

Aim: To identify and report how gender justice is conceptualised and discussed in contemporary health literature in relation to the Triple Planetary Crisis of climate change, pollution and biodiversity loss, with a particular focus on the experiences of women and gender-diverse populations, and the representation of nurses and other healthcare professionals dominated by women. Design: Scoping review. Data Sources: Searches were conducted across MEDLINE (Ovid), Scopus, CINHAL, Embase and ProQuest, focusing on studies published from January 1 2000–23 September 2024. Review Methods: The review was conducted in accordance with the JBI methodology for scoping reviews and reported against the Preferred …


Attitudes And Expectations Towards Acupuncture For Primary Dysmenorrhoea: Findings From A Cross-Sectional Survey In Australia, Weiting Liu, Amanda Towell-Barnard, Khui Hung Lee, Timothy Leen Kang Jan 2026

Attitudes And Expectations Towards Acupuncture For Primary Dysmenorrhoea: Findings From A Cross-Sectional Survey In Australia, Weiting Liu, Amanda Towell-Barnard, Khui Hung Lee, Timothy Leen Kang

Research outputs 2022 to 2026

Objective: To describe attitudes towards acupuncture and expectations regarding potential treatment outcomes among women with self-reported primary dysmenorrhoea (PD) residing in Australia. Methods: A cross-sectional, descriptive online survey was conducted to assess attitudes and treatment expectancy using an adapted version of previously published complementary and alternative medicine (CAM) attitude scale and a validated acupuncture expectancy scale (AES). Data were analysed descriptively, with exploratory analysis conducted to support the interpretation of response patterns. Ethical approval was obtained from the Edith Cowan University Human Research Ethics Committee (2023-04471-LIU) and participants provided electronic informed consent. Results: A total of 247 responses were received. …


Cardiovascular–Kidney–Metabolic Syndrome Through The Lens Of Gut‑Derived Uremic Toxins, Chudan Xu, Matthew Snelson, Francine Z. Marques Jan 2026

Cardiovascular–Kidney–Metabolic Syndrome Through The Lens Of Gut‑Derived Uremic Toxins, Chudan Xu, Matthew Snelson, Francine Z. Marques

Research outputs 2022 to 2026

Cardiovascular–Kidney–Metabolic (CKM) syndrome represents a complex, interconnected cluster of cardiovascular disease, chronic kidney disease, and metabolic disorders such as obesity and type 2 diabetes. These conditions share overlapping metabolic, inflammatory, and vascular pathways, with the gut microbiome increasingly recognised as a key contributor and common underlying risk factor. Uremic toxins, traditionally considered waste products of host and microbial metabolism, are now recognised as active mediators of tissue damage across the CKM spectrum, particularly in the context of impaired renal function. Their production and accumulation are amplified by disrupted intestinal barrier integrity, chronic inflammation, and reduced renal clearance, collectively driving systemic …


Emerging Blood-Based Biomarkers For The Detection Of Parenchymal Brain Metastasis: Current Progress And Future Perspectives, Désirée Sexauer, Elin S. Gray, Helen Rizos, Pauline Zaenker, Aaron B. Beasley Jan 2026

Emerging Blood-Based Biomarkers For The Detection Of Parenchymal Brain Metastasis: Current Progress And Future Perspectives, Désirée Sexauer, Elin S. Gray, Helen Rizos, Pauline Zaenker, Aaron B. Beasley

Research outputs 2022 to 2026

Parenchymal brain metastases of solid malignancies remain a significant clinical challenge, as they are often detected at later symptomatic stages, which are typically associated with worse prognosis. Delayed detection limits treatment options and contributes to poor outcomes, while early detection is critical for improving patient outcomes and quality of life. In this comprehensive review, we investigated the potential use and challenges of blood-based biomarkers, including circulating tumor cells, cell-free DNA, noncoding RNAs, extracellular vesicles, proteins, and other immune-related biomarkers, for the early detection of parenchymal brain metastasis. The use of blood-based liquid biopsies offers a promising avenue for early detection …


Implementation Of Risk Prediction And Stratification Approaches For Ageing Populations In Australian Healthcare: A Systematic Review, Leanne Greene, Jacob Brain, Belinda Brown, Claire V. Burley, Elissa Burton, Zhongyang Guan, Bronwyn Myers, Katherine Ride, Serena Sabatini, Mario Siervo, Abay Woday Tadesse, Eugene Yee Hing Tang, Blossom C.L. Stephan, Jennifer Dunne Jan 2026

Implementation Of Risk Prediction And Stratification Approaches For Ageing Populations In Australian Healthcare: A Systematic Review, Leanne Greene, Jacob Brain, Belinda Brown, Claire V. Burley, Elissa Burton, Zhongyang Guan, Bronwyn Myers, Katherine Ride, Serena Sabatini, Mario Siervo, Abay Woday Tadesse, Eugene Yee Hing Tang, Blossom C.L. Stephan, Jennifer Dunne

Research outputs 2022 to 2026

Despite widespread development of prognostic risk stratification tools, their implementation in Australian healthcare remains poorly characterised. This review identified tools implemented for adults aged ≥40 years and examined their real-world use. Following PRISMA and SWiM guidelines, MEDLINE, EMBASE, Web of Science, PsycINFO, and CINAHL Plus were searched from inception to 20th February 2026. Eligible studies reported implementation of a risk stratification tool in Australian healthcare and health, functional, or implementation outcomes. The Mixed Methods Appraisal Tool assessed study quality. Of 7115 records screened, 21 studies were included across primary care, hospitals, residential aged care, and community services. Interventions included electronic …


Is A Fear Of Death Keeping You Awake At Night? Death Anxiety Predicts Insomnia Through Nightmare Severity, Rachel E. Menzies, Jessie Brown, Mitchell Turner, David Cunnington, Malisa Burge, Ian C. Dunican, Hailey Meaklim Jan 2026

Is A Fear Of Death Keeping You Awake At Night? Death Anxiety Predicts Insomnia Through Nightmare Severity, Rachel E. Menzies, Jessie Brown, Mitchell Turner, David Cunnington, Malisa Burge, Ian C. Dunican, Hailey Meaklim

Research outputs 2022 to 2026

The fear of death (death anxiety) is a risk factor for various mental health conditions. Death anxiety has been theorized to elicit physiological arousal and worry and is empirically associated with attachment insecurity, each of which has been linked to disrupted sleep. However, limited research has explored the relationship between death anxiety, nightmares and insomnia. We examined the relationship between death anxiety and insomnia, as well as attachment style as a potential moderator, and nightmare severity as a possible mediator. Five hundred and fifteen adults completed an online survey; 70% were female, and 89% resided in Australia. Regression analyses revealed …


Maternal Prebiotic Supplementation Modifies Associations Between Intrapartum Antibiotics And Infant Allergy, Summer V.M. Walker, Thomas R. Sullivan, Rachelle A, Pretorius, Nina D'Vaz, Johnny Lo, Johan Garssen, Jeffrey A. Keelan, Desiree Silva, Susan L. Prescott, Claus T. Christophersen, Debra J. Palmer Jan 2026

Maternal Prebiotic Supplementation Modifies Associations Between Intrapartum Antibiotics And Infant Allergy, Summer V.M. Walker, Thomas R. Sullivan, Rachelle A, Pretorius, Nina D'Vaz, Johnny Lo, Johan Garssen, Jeffrey A. Keelan, Desiree Silva, Susan L. Prescott, Claus T. Christophersen, Debra J. Palmer

Research outputs 2022 to 2026

Background: Prebiotics promote growth of beneficial gut bacteria, whereas antibiotics can disrupt the microbial balance, reduce diversity, and potentially cause gut dysbiosis. This investigation aimed to determine whether antibiotic use before, during, or after birth altered the risk of infant allergic disease outcomes within a maternal prebiotic dietary supplementation trial. Methods: Maternal participants were allocated to consume daily prebiotics (galacto-oligosaccharides and fructo-oligosaccharides) or placebo (maltodextrin) powder from 18 to 20 weeks' gestation until 6 months postnatal. All infants had a family history of allergic disease. Maternal and infant antibiotic use was prospectively collected monthly throughout the trial intervention period, and …


Measuring Mental Health Promoting Behaviours: Development And Psychometric Properties Of A Danish Act Belong Commit-Mental Health Promoting Behaviours (Abc-Mhpb) Scale, Line Nielsen, Ziggi Ivan Santini, Malene Kubstrup Nelausen, Carsten Hinrichsen, Frederik Schou-Juul, Vibeke Jenny Koushede, Robert J. Donovan, Charlotte Bjerre Meilstrup Jan 2026

Measuring Mental Health Promoting Behaviours: Development And Psychometric Properties Of A Danish Act Belong Commit-Mental Health Promoting Behaviours (Abc-Mhpb) Scale, Line Nielsen, Ziggi Ivan Santini, Malene Kubstrup Nelausen, Carsten Hinrichsen, Frederik Schou-Juul, Vibeke Jenny Koushede, Robert J. Donovan, Charlotte Bjerre Meilstrup

Research outputs 2022 to 2026

Background: The Act Belong Commit-ABCs of Mental Health campaign is the world’s first comprehensive, population-wide, community-based initiative to promote mental health. In response to a growing demand for valid tools to monitor mental health promoting behaviours, this study presents the development and psychometric evaluation of the ABC-Mental Health Promoting Behaviours (ABC-MHPB) scale in a Danish population-based sample. Methods: A 10-item scale was developed, based on the ABC framework, to assess mental health promoting behaviours. A total of 119,221 randomly selected participants aged 18+ filled out an electronic survey, including the scale to measure the underlying construct of mental health promoting …


The Basis For Recommending The Selection Of Samplers In Determining Occupational Exposures To Aerosols, Martin Harper, Pieter Bertier, Marcus Cattani, Karen Galea, Darrah Sleeth, Steven Verpaele Jan 2026

The Basis For Recommending The Selection Of Samplers In Determining Occupational Exposures To Aerosols, Martin Harper, Pieter Bertier, Marcus Cattani, Karen Galea, Darrah Sleeth, Steven Verpaele

Research outputs 2022 to 2026

Measurements are considered to be the basis of exposure assessments used to determine risks to workers. Inhalation exposure poses the greatest risk for most airborne chemicals, and measurements are based on collecting (sampling) and analyzing air samples. Samplers have been developed for more than 120 years. Each new design has been intended to address flaws perceived in earlier designs. Users are faced with a varied array of samplers from which to choose. Comparisons are difficult to make because tests of sampler performance were not standardized until recently and have not been applied consistently. The existing large body of work does …


The Impact Of A Vancomycin Intervention On Vancomycin-Associated Nephrotoxicity In Children: A Quality Improvement Initiative, Megan R. Nettleton, Hwi Eun Mary Shim, Joanne Abbotsford, Zoy Goff, Briony Hazelton, Matthew O'Brien, Tenielle Porter, Thomas Snelling, Daniel K. Yeoh, Asha C. Bowen, Christopher C. Blyth, Anita J. Campbell Jan 2026

The Impact Of A Vancomycin Intervention On Vancomycin-Associated Nephrotoxicity In Children: A Quality Improvement Initiative, Megan R. Nettleton, Hwi Eun Mary Shim, Joanne Abbotsford, Zoy Goff, Briony Hazelton, Matthew O'Brien, Tenielle Porter, Thomas Snelling, Daniel K. Yeoh, Asha C. Bowen, Christopher C. Blyth, Anita J. Campbell

Research outputs 2022 to 2026

Background: Vancomycin is first-line treatment for methicillin-resistant Staphylococcus aureus (MRSA) infections. However, despite guideline recommendations, there is no evidence that targeting vancomycin trough concentrations of ≥15 mg/L in children confers clinical benefit and is associated with vancomycin-associated nephrotoxicity (VAN). Aim: This study aimed to evaluate the impact of a vancomycin safety bundle on VAN and vancomycin utilisation in hospitalised paediatric inpatients. Method: A pre–post-intervention study was conducted in a tertiary paediatric hospital comparing January–December 2018 (pre-intervention) to May 2019–April 2020 (post-intervention). Hospitalised children, aged 30 days to <18 years, that received intravenous vancomycin with at least one trough concentration were included. The intervention bundle comprised: (1) lowered empiric vancomycin trough targets (5–15 mg/L), (2) enhanced creatinine monitoring (concomitant serum creatinine with vancomycin trough), (3) guideline modification (reduced pre-authorised indications for empiric vancomycin use), and (4) prescriber education initiatives. Ethical approval was granted by the WA Child and Adolescent Health Service Research Ethics Committee, Governance Evidence Knowledge Outcomes Program (Reference no: 41830) and the study conforms with the National Health and Medical Research Council's Ethical considerations in quality assistance and evaluation activities. Results: A total of 314 vancomycin prescriptions were analysed (n = 204 pre-intervention; n = 110 post-intervention). Post-intervention, VAN incidence decreased almost twofold from 0.46 to 0.25 episodes per 1000 patient bed days (p ≤ 0.01), and vancomycin prescription days decreased by 19%. Total hospital drug costs for vancomycin decreased by AUD $16 033. Overall, and for paediatric invasive MRSA, no significant difference in clinical outcomes or 30-day mortality was observed between study periods. Conclusion: This study demonstrated the implementation of a vancomycin safety bundle significantly reduced paediatric VAN and vancomycin utilisation without compromising clinical outcomes. These data support antimicrobial stewardship interventions to improve medication safety for children.


National Consensus On The Capabilities That Inform The Role Of Advanced Practice Paramedics: A Delphi Study, Alessia Restiglian, Lorna Martin, David Long, Louise Reynolds, Tony Walker, Ben Meadley, Ashleigh Finn, Alan Batt, Alecka Miles, Tania Johnston, Brendan Shannon Jan 2026

National Consensus On The Capabilities That Inform The Role Of Advanced Practice Paramedics: A Delphi Study, Alessia Restiglian, Lorna Martin, David Long, Louise Reynolds, Tony Walker, Ben Meadley, Ashleigh Finn, Alan Batt, Alecka Miles, Tania Johnston, Brendan Shannon

Research outputs 2022 to 2026

Advanced Practice Paramedics (APPs) are highly skilled paramedics who operate in diverse clinical settings both within and outside traditional ambulance services. International evidence demonstrates that APPs enhance patient outcomes in areas such as critical and primary care. In Australia, the expansion of APP roles and responsibilities has gained momentum; however, no nationally recognised framework exists to define their expected capabilities. This gap leads to inconsistencies in education, practice and role clarity. A standardised capability framework is therefore vital to guide the development, implementation and integration of APP roles within the Australian healthcare system. The primary aim of this study was …


Superior Effects Of High-Intensity Interval Eccentric Cycling Training On Neuromuscular Adaptations With Similar Aerobic Adaptations To Concentric Cycling, Marcin Lipski, Joanne Trezise, Chris R. Abbiss, Kazunori Nosaka Jan 2026

Superior Effects Of High-Intensity Interval Eccentric Cycling Training On Neuromuscular Adaptations With Similar Aerobic Adaptations To Concentric Cycling, Marcin Lipski, Joanne Trezise, Chris R. Abbiss, Kazunori Nosaka

Research outputs 2022 to 2026

Purpose: We compared the effects of high-intensity interval eccentric (EC) versus concentric cycling (CC) training on aerobic capacity, muscle function and morphology. Methods: Healthy men (19–56 y) performed EC (n = 9) or CC (n = 8) training twice a week for 8 weeks. The training progressed from 5 × 2-min intervals with 1-min rest to 7 × 2-min intervals with 30-s rest. EC and CC were matched for perceived effort, and progressed from 30 to 36% of concentric peak power output (PPO10s) for CC and from 45 to 70% PPO10s for EC. Changes in peak oxygen consumption (VO2peak), incremental …


The Effectiveness Of Virtual Reality Aggression And Violence De-Escalation Training For Nursing And Midwifery Students: A Quasi-Experimental Study, Joshua Johnson, Brennen Mills, Luke Hopper, Sara Hansen, Kelley Mumford, Renju Joseph, Susan Philip, Gina Kruger, Abdi D. Osman Jan 2026

The Effectiveness Of Virtual Reality Aggression And Violence De-Escalation Training For Nursing And Midwifery Students: A Quasi-Experimental Study, Joshua Johnson, Brennen Mills, Luke Hopper, Sara Hansen, Kelley Mumford, Renju Joseph, Susan Philip, Gina Kruger, Abdi D. Osman

Research outputs 2022 to 2026

Background: Nursing students experience substantial exposure to aggression and violence while attending clinical placement. De-escalation training can effectively prepare students for aggressive encounters, yet is resource-intensive to deliver. Immersive virtual reality (VR) may improve training accessibility for nursing students. Aim: To evaluate the effectiveness of a VR de-escalation training program to improve nursing students’ confidence in managing patient aggression and its perceived usability. Methods: This study utilized a single-group quasi-experimental pre-/post-test design. Undergraduate Australian nursing students (n = 221) completed a VR de-escalation training program, providing pre-/postintervention self-reported confidence in coping with patient aggression, system usability, and motion sickness data. …


Do Combined Resistance And Aerobic Exercise Programs Cause An Interference Effect In Women With Breast Cancer? A Systematic Review And Network Meta-Analysis, Pedro Lopez, Anderson Rech, Maria Petropoulou, Caroline B. Silveira, Talita Molinari, Cindranne Torres Muller, Priscila Casara, Francesco Bettariga, Favil Singh, Régis Radaelli Jan 2026

Do Combined Resistance And Aerobic Exercise Programs Cause An Interference Effect In Women With Breast Cancer? A Systematic Review And Network Meta-Analysis, Pedro Lopez, Anderson Rech, Maria Petropoulou, Caroline B. Silveira, Talita Molinari, Cindranne Torres Muller, Priscila Casara, Francesco Bettariga, Favil Singh, Régis Radaelli

Research outputs 2022 to 2026

Background: Exercise medicine has gained significant recognition owing to its demonstrated benefits throughout the breast cancer treatment continuum. While resistance exercise (RE) promotes improvements in lean mass and muscle strength, aerobic exercise (AE) enhances cardiorespiratory fitness, with several studies investigating both exercise modes in patients with breast cancer. However, because of an effect often referred to as interference effect, it is hypothesised that combining resistance and aerobic exercise (COMB) may compromise gains in lean mass and muscle strength and other outcomes in cancer populations. Objective: This study aims to investigate the presence of an interference effect from prescribing COMB compared …


International Cardiac Advanced Life Support Course: A Cross-Sectional Descriptive Analysis, Nilufeur Mckay, Jody Ede, Jessica Stokes-Parish, Adrian Levine, Helen Walthall, Debbie Massey Jan 2026

International Cardiac Advanced Life Support Course: A Cross-Sectional Descriptive Analysis, Nilufeur Mckay, Jody Ede, Jessica Stokes-Parish, Adrian Levine, Helen Walthall, Debbie Massey

Research outputs 2022 to 2026

Background: Recognising and responding to cardiac surgical deterioration requires a systematic, structured approach that encompasses monitoring, identifying and managing signs and symptoms of post-surgical complications. Cardiac Advanced Life Support (CALS) was originally developed in recognition of this educational requirement and consists of a series of protocols aimed at supporting clinicians’ recognition and response to the deteriorating cardiac surgical patient. Aim: The aim of this analysis was to evaluate participant perceptions of a CALS course using a descriptive online survey. Design: A cross-sectional analysis of post-course online survey responses assessing participant’ perceptions of the CALS course. Results: 331 surveys were returned …


What Is Resistance Exercise? A Review Of Current Uses And Potential Ways Forward, Lars H. Lohmann, José Afonso, David G. Behm, Stanislaw D. Siegel, Michael Keiner, Klaus Wirth, Anthony J. Blazevich, Eric R. Helms, Alyssa Joy Spence, Konstantin Warneke Jan 2026

What Is Resistance Exercise? A Review Of Current Uses And Potential Ways Forward, Lars H. Lohmann, José Afonso, David G. Behm, Stanislaw D. Siegel, Michael Keiner, Klaus Wirth, Anthony J. Blazevich, Eric R. Helms, Alyssa Joy Spence, Konstantin Warneke

Research outputs 2022 to 2026

The resistance exercise (RE) literature highlights the importance and impact of RE in sports performance, daily life, and clinical outcomes. While RE research dates back to the 19th century, current definitions of what constitutes RE are varied and give rise to questions about the requisites of RE. For example, some definitions refer to movements or muscle contractions against external resistance whereas others consider all repeated actions against one’s bodyweight. Taken to the limit, this could introduce confusion between RE and endurance exercise, for example. Without a clear definition, systematic reviews (with meta-analysis) discuss outcomes of studies examining the effects of …


A Mass Cytometry-Based Blood Cell Phenotyping Workflow Enabling Inclusion Of Resource-Limited And Rural Sites In Immune System Studies, Natalie J. Smith, Michael Cohen, Lauren Tracey, Julie Alipaz, Christina Loh, David King, Neha Pulyani, Rebecca Auzins, Elin Gray, Sandra Taylor, Rajat Rai, Steven Kao, Barbara Fazekas De St Groth, Helen M. Mcguire Jan 2026

A Mass Cytometry-Based Blood Cell Phenotyping Workflow Enabling Inclusion Of Resource-Limited And Rural Sites In Immune System Studies, Natalie J. Smith, Michael Cohen, Lauren Tracey, Julie Alipaz, Christina Loh, David King, Neha Pulyani, Rebecca Auzins, Elin Gray, Sandra Taylor, Rajat Rai, Steven Kao, Barbara Fazekas De St Groth, Helen M. Mcguire

Research outputs 2022 to 2026

Insight into disease detection and treatment through comprehensive immune phenotyping relies on the generation of high-quality data. However, the execution of robust immune monitoring in clinical trials by flow cytometry is complex due to logistical challenges in sample preparation and reagent stability. These challenges are exacerbated when considering remote and rural communities in Australia, which are burdened by both an increased prevalence and a worse prognosis of many chronic and infectious pathologies. This is not unique to the Australian context as globally remote and rural communities are underrepresented in biomedical research studies, contributing to persistent health inequities. To address these …


Multidimensional Sleep Health And Sleep Environment Factors In Individuals With Cancer Undergoing Outpatient Chemotherapy: An Exploratory Cross-Sectional Analysis, Sam Adams, D. Clay, Arman Hasani, Mitchell Turner, Travis Cruickshank Jan 2026

Multidimensional Sleep Health And Sleep Environment Factors In Individuals With Cancer Undergoing Outpatient Chemotherapy: An Exploratory Cross-Sectional Analysis, Sam Adams, D. Clay, Arman Hasani, Mitchell Turner, Travis Cruickshank

Research outputs 2022 to 2026

Purpose: Sleep problems are common amongst individuals with cancer receiving chemotherapy and are associated with poorer health outcomes. Considerable research to date has investigated specific sleep domains or symptomology, with little attention given to overall sleep health, which is more closely associated with overall health. This exploratory cross-sectional study aimed to characterize multidimensional sleep health in individuals with cancer reporting sleep complaints whilst undergoing chemotherapy, with exploratory examination of environmental associations. Patients and Methods: Twenty-three participants were included in this exploratory cross-sectional analysis. Participants were diagnosed with cancer within the last 6 months, undergoing outpatient chemotherapy at time of study …


Quantifying Nurse And Midwife-Led Research Impact: Retrospective Application Of The Framework To Assess The Impact From Translational Health Research (Fait) Model On Two Exemplar Randomised Controlled Trials, Kim Neylon, Rouen, Lisa Whitehead, Greg Sharplin, Kathleen Baird, Marion Eckert Jan 2026

Quantifying Nurse And Midwife-Led Research Impact: Retrospective Application Of The Framework To Assess The Impact From Translational Health Research (Fait) Model On Two Exemplar Randomised Controlled Trials, Kim Neylon, Rouen, Lisa Whitehead, Greg Sharplin, Kathleen Baird, Marion Eckert

Research outputs 2022 to 2026

Background: Nurse- and midwife-led clinical trials are underrepresented in Australia and New Zealand, despite their potential to improve health outcomes and deliver economic value. Demonstrating the broader impact of such research is essential to inform policy and funding decisions. Aim: To assess the utility of the Framework to Assess the Impact from Translational health research (FAIT) in capturing the translational impact of nurse- and midwife-led randomised controlled trials through retrospective application to two exemplar studies. Methods: FAIT was retrospectively applied to the RSVP (nurse-led) and DAME (midwife-led) trials using three components: Modified Payback, Economic Analysis, and Narrative. Program Logic Models …


S-Methyl Cysteine Sulfoxide: Its Effects On Cardiometabolic Outcomes In High-Fat Fed C57bl/6 Mice And Relevance To Human Health, Caroline R. Hill, Balmer, Hayley Abbiss, Jonathan M. Hodgson, Joshua R. Lewis, Armaghan Shafaei, Lauren C. Blekkenhorst Jan 2026

S-Methyl Cysteine Sulfoxide: Its Effects On Cardiometabolic Outcomes In High-Fat Fed C57bl/6 Mice And Relevance To Human Health, Caroline R. Hill, Balmer, Hayley Abbiss, Jonathan M. Hodgson, Joshua R. Lewis, Armaghan Shafaei, Lauren C. Blekkenhorst

Research outputs 2022 to 2026

S-Methyl cysteine sulfoxide (SMCSO) is an organosulfur compound with demonstrated hypocholesterolemic, anti-diabetic, and antioxidant benefits in rodents. However, the doses used have limited translatability for humans. We explored whether SMCSO could blunt development of diet-induced metabolic syndrome features in mice using doses that are potentially more translatable and achievable in humans. Male mice (C57BL/6; n = 54) were randomly assigned into one of five groups: [1] normal-diet; [2] high-fat-diet; or high-fat-diet with [3] 60 mg kg−1, [4] 170 mg kg−1, or [5] 350 mg per kg per body weight (BW) of SMCSO, respectively. Doses were administered …


Emergency Clinicians’ Knowledge And Practice Of Pain Assessment For Older Adults With Cognitive Impairment: A Cross-Sectional Study, Carrie Janerka, Kaoru Nosaka, Aaron Lapuz Alejandro, Jeffery Hughes, Natasya Raja Azlan, Amineh Rashidi, Wenhong Zhao, Rosemary Saunders Jan 2026

Emergency Clinicians’ Knowledge And Practice Of Pain Assessment For Older Adults With Cognitive Impairment: A Cross-Sectional Study, Carrie Janerka, Kaoru Nosaka, Aaron Lapuz Alejandro, Jeffery Hughes, Natasya Raja Azlan, Amineh Rashidi, Wenhong Zhao, Rosemary Saunders

Research outputs 2022 to 2026

Background Older adults with cognitive impairment frequently present to emergency departments and often experience poor pain management. Patients’ impaired self-reporting, limited clinician training, inconsistent use of behavioural tools, and environmental pressures have been reported challenges. This study examined emergency clinicians’ knowledge and practices in assessing pain for this population. Methods A descriptive cross-sectional survey was conducted across two emergency departments in Australia. An 86-item survey collected clinicians’ pain assessment knowledge and practices. Quantitative data were analysed using descriptive statistics, and qualitative responses were thematically analysed. Results 148 clinicians (110 nurses, 21 doctors, 17 allied health staff) responded to the survey …


Nursing Leadership And Pandemic Preparedness Via Game-Based Learning Simulation: A Narrative Review (Registered Nurses And Undergraduate Nursing Students), Scott James Andrews, Olivia Gallagher, Alecka Miles, Carol Crevacore, Brennen Mills Jan 2026

Nursing Leadership And Pandemic Preparedness Via Game-Based Learning Simulation: A Narrative Review (Registered Nurses And Undergraduate Nursing Students), Scott James Andrews, Olivia Gallagher, Alecka Miles, Carol Crevacore, Brennen Mills

Research outputs 2022 to 2026

Background: Early progression of newly registered nurses into leadership roles is commonplace in clinical settings. Nurses and student nurses can prepare for leadership by gaining exposure through simulation-based learning. A novel and expanding modality are game-based learning (GBL) simulation. Nurse leaders play a crucial role during pandemics, guiding their teams through crises and ensuring effective response strategies. Reviewing the literature to identify the content, structure, and effectiveness of current pandemic preparedness and GBL simulation in nursing education is necessary to identify lessons learnt during the COVID-19 pandemic response to guide workforce preparation for future surge planning. Aim: The aim of …


Reflections From A Community Capacity Building Forum To Support People Bereaved By Suicide, Colleen Carlon, Jacquie Tarrant, Marie Eckersley, Priscilla Vindin Jan 2026

Reflections From A Community Capacity Building Forum To Support People Bereaved By Suicide, Colleen Carlon, Jacquie Tarrant, Marie Eckersley, Priscilla Vindin

Research outputs 2022 to 2026

An estimated half the population may be impacted by suicide loss. The combination of grief and trauma makes the experience particularly complex. Recognised as the most stigmatised of all sudden losses people bereaved by suicide are in sociocultural contexts that disrupt constructive grief processes and create barriers for help seeking and supportive responses. Effecting change in this context poses a significant health promotion challenge. Social workers in the South West Region of Western Australia sought to develop and deliver a unique postvention approach aimed at strengthening the self-support capacity of people bereaved by suicide while building broader community capacity for …


Methodological Considerations For Studies In Sport And Exercise Science With Women As Participants Part Ii: Guidance For Applied Studies In Elite Female Athletes, Kirsty J. Elliott-Sale, Richard J. Burden, Kathryn E. Ackerman, Louise M. Burke, Naama Constantini, Anthony C. Hackney, Rachel Harris, Franco M. Impellizzeri, Xanne A.K. Janse De Jonge, Constance M. Lebrun, Clare Minahan, Sophia Nimphius, Stuart M. Phillips, Sarianna Sipilä, Juliette A. Strauss, Paul Swinton, Craig Sale Jan 2026

Methodological Considerations For Studies In Sport And Exercise Science With Women As Participants Part Ii: Guidance For Applied Studies In Elite Female Athletes, Kirsty J. Elliott-Sale, Richard J. Burden, Kathryn E. Ackerman, Louise M. Burke, Naama Constantini, Anthony C. Hackney, Rachel Harris, Franco M. Impellizzeri, Xanne A.K. Janse De Jonge, Constance M. Lebrun, Clare Minahan, Sophia Nimphius, Stuart M. Phillips, Sarianna Sipilä, Juliette A. Strauss, Paul Swinton, Craig Sale

Research outputs 2022 to 2026

The purpose of this statement is to guide the design and conduct of high-quality sport and exercise science studies investigating the effects of varied ovarian hormone profiles on the health and athletic performance of elite female athletes. Beyond the menstrual cycle, these athletes present with a wide range of ovarian hormone profiles, including those associated with puberty and menarche, menstrual dysfunction, hormonal contraceptive use, pregnancy and postpartum, perimenopause, menopause and post-menopause. To effectively integrate knowledge of ovarian hormone profiles into high-performance sport and address the diverse needs of female athletes, future research and educational initiatives must encompass this broader spectrum …


Scope And Adherence To The Consider Statement In Aboriginal And Torres Strait Islander Injury Prevention Research In Australia, Bep Uink, Michelle Barrett, Courtney Ryder, Aleina Humphreys, Graham Peter Barker Jan 2026

Scope And Adherence To The Consider Statement In Aboriginal And Torres Strait Islander Injury Prevention Research In Australia, Bep Uink, Michelle Barrett, Courtney Ryder, Aleina Humphreys, Graham Peter Barker

Research outputs 2022 to 2026

Introduction: Effective injury prevention for Aboriginal and Torres Strait Islander people hinges on the availability of culturally safe policies, resources and programmes, alongside best-practice research. Contemporary injury prevention research has increasingly centred Aboriginal and Torres Strait Islander knowledges, yet there is still room for improvement. Identification of relevant resources, policies and programmes, as well as the extent to which injury prevention research meets international criteria for ethical research with Aboriginal and Torres Strait Islander peoples will provide practitioners with critical insights into best-practice injury prevention initiatives. Method: We examined the breadth and scope of Aboriginal and Torres Strait Islander injury-related …


Periodontitis During Pregnancy: The Effect On The Gut Microbiome And Intestinal Inflammation, Richard Bright, G. Macowan, Keyuan Tian, Tracy Fitzsimmons, Rebecca L. Wilson, Claire T. Roberts, Claus T. Christophersen, Peter M. Bartold, Stephen P. Kidd, Peter S. Zilm Jan 2026

Periodontitis During Pregnancy: The Effect On The Gut Microbiome And Intestinal Inflammation, Richard Bright, G. Macowan, Keyuan Tian, Tracy Fitzsimmons, Rebecca L. Wilson, Claire T. Roberts, Claus T. Christophersen, Peter M. Bartold, Stephen P. Kidd, Peter S. Zilm

Research outputs 2022 to 2026

Background: Periodontitis has been epidemiologically associated with adverse pregnancy outcomes, but causality remains difficult to establish in humans due to confounding factors. This study uses a controlled murine model to examine the effects of experimentally induced periodontitis on the composition of the gut microbiota and gastrointestinal inflammation during pregnancy. Methods: Periodontitis was induced in pregnant BALB/c mice via oral inoculation with Porphyromonas gingivalis and Fusobacterium nucleatum before conception (n = 20 per group). Pregnancy outcomes, gut histology, systemic inflammatory markers, and microbiome composition, assessed by 16S rRNA sequencing, were evaluated at gestational Day 18. Results: Periodontitis was confirmed by significant …


Risk Factors Associated With Delayed Secretory Activation In A Cohort Of Nulliparous Women In Western Australia, Cassandra Cuffe, Giglia, Julie Hill, Matthew N. Cooper, Anita M. Moorhead, Joshua R. Lewis, Deborah Ireson, Therese A. O’Sullivan Jan 2026

Risk Factors Associated With Delayed Secretory Activation In A Cohort Of Nulliparous Women In Western Australia, Cassandra Cuffe, Giglia, Julie Hill, Matthew N. Cooper, Anita M. Moorhead, Joshua R. Lewis, Deborah Ireson, Therese A. O’Sullivan

Research outputs 2022 to 2026

Background: Delayed secretory activation can negatively impact maternal and child health through increasing the risk of early cessation of breastfeeding. Early cessation of breastfeeding is known to be associated with increased health risks. Aim: To determine the occurrence of, and risk factors associated with, delayed secretory activation in nulliparous women in Western Australia. Methods: This analysis used a subset of participants (n = 183) enrolled in a multicentre trial. Nulliparous low-risk pregnant women were enrolled between 28–32 weeks’ gestation and followed until 1 week after birth. The association between self-reported delayed secretory activation status (onset 4 days or more postpartum) …


Forced Oscillation Technique In Pneumothorax (Pneumofot) Study, Niranjan Ananda Setty, Carolyn J. Mcintyre, John Blakey, Yun Chor Gary Lee Jan 2026

Forced Oscillation Technique In Pneumothorax (Pneumofot) Study, Niranjan Ananda Setty, Carolyn J. Mcintyre, John Blakey, Yun Chor Gary Lee

Research outputs 2022 to 2026

Forced Oscillation Technique in Pneumothorax (PneumoFOT) study A single-centre prospective pilot feasibility study designed to assess the feasibility of performing FOT measurements in patients with pneumothorax. STATISTICAL ANALYSIS PLAN Version 24.05.2026


Overview Of Aboriginal And Torres Strait Islander Health Status 2025, Australian Indigenous Healthinfonet Jan 2026

Overview Of Aboriginal And Torres Strait Islander Health Status 2025, Australian Indigenous Healthinfonet

Research outputs 2022 to 2026

This Overview provides a summary of the most recent indicators of the health and wellbeing of Aboriginal and Torres Strait Islander people (of all ages, where data are available). The topics included in the Overview cover chronic health conditions which are featured on the HealthInfoNet website. Over the years as additional funding has been obtained and in consultation with HealthInfoNet networks, more topics have been covered on the website and are now included in the Overview. The topics aim to reflect the status of Aboriginal and Torres Strait Islander health over this period and going forward.


Advances In Survival Analyses: Machine Learning Methods And Model Comparison, Ryan Gately, Dharshana Sabanayagam, Wai H. Lim, Lin Zhu, Farzaneh Boroumand, Shuvo Bakar, Armando Teixeira-Pinto, Germaine Wong Jan 2026

Advances In Survival Analyses: Machine Learning Methods And Model Comparison, Ryan Gately, Dharshana Sabanayagam, Wai H. Lim, Lin Zhu, Farzaneh Boroumand, Shuvo Bakar, Armando Teixeira-Pinto, Germaine Wong

Research outputs 2022 to 2026

This is the second article in a 2-part series on survival analysis. In part 1, we discussed the core concepts and traditional methods used in survival analysis. Part 2 explores the novel approaches to predict survival outcomes and evaluate model performance. To facilitate hands-on learning and practical implementation, the R code used in these analyses is provided in the supplementary materials, along with instructions to help readers apply these methods to their data.