Medicine and Health Sciences Commons^™

Dietary Organic Selenium Supplementation Improved Some Gross Morphological Parameters And Biochemical Characteristics Of Testes In Young Male Kids, Nadia Rahim, Moolchand Malhi, Asma Babar, Muhammad Awais Soomro, Shazia Rahim

Journal of Bioresource Management

Selenium (Se) plays a vital role in improving reproductive health in ruminants. This study evaluated the impact of Se supplementation on testicular health in young male goats. Twenty goats (2–3 months old, 8.5–10 kg) were randomly assigned to two groups: Control (C, n=10) receiving a basal diet (0.037 mg Se/kg) and Se-Yeast (SY, n=10) supplemented with 0.3 mg Se/kg diet. The trial lasted eight weeks. Results showed that testis weight was significantly higher in the SY group (26.8 ± 2.5 g) compared to C (22.4 ± 2.1 g, p < 0.05). Testis length, width, and circumference also increased significantly in SY goats (4.5 ± 0.3 cm, 2.9 ± 0.2 cm, and 7.4 ± 0.4 cm, respectively) compared to control (3.9 ± 0.4 cm, 2.5 ± 0.3 cm, and 6.7 ± 0.5 cm; p < 0.05). Serum cholesterol was higher in SY (135.27 ± 2.34 mg/dl) than in C (121.15 ± 8.74 mg/dl, p = 0.02), while triglycerides were lower (95.99 ± 1.37 vs. 114.38 ± 1.84 mg/dl, p = 0.0003). HDL increased (51.97 ± 2.10 vs. 45.02 ± 1.32 mg/dl, p = 0.03), and LDL decreased (54.23 ± 1.81 vs. 61.27 ± 1.56 mg/dl, p = 0.02) in SY group. Total serum protein rose significantly (8.14 ± 0.79 vs. 5.25 ± 0.06 mg/dl, p = 0.03), as did testosterone levels (1.95 ± 0.08 vs. 1.43 ± 0.06 ng/ml, p = 0.002). In conclusion, selenium supplementation significantly improved testicular morphology, lipid profile, protein levels, and testosterone, indicating enhanced reproductive health in goats.

Documenting Our Success Stories: Merits Of Case Reporting In Homoeopathic Research And Practice, Subhash Kaushik

Indian Journal of Research in Homoeopathy

Editorial

Segmental Vitiligo Treated By Homoeopathic Constitutional Medicine Tuberculinum: An Evidence-Based Case Report, Shubham Grover, Ashwini Nair

Indian Journal of Research in Homoeopathy

Introduction: Vitiligo is characterised by a patchy loss of skin pigmentation, which most commonly occurs due to the immune system targeting melanocytes in the epidermis. A few studies have shown the effectiveness of Homoeopathy in halting the progression and replacing the hypo-pigmented patches with normal-pigmented skin. Case Summary: A 15-year-old boy came to the clinic complaining of white patches that appeared suddenly on various parts of his body within one week. Tuberculinum proved to be the constitutional medicine in this case. The photographic evidence taken at regular intervals and a follow-up of over nine months showed the potential of constitutional …

Management Of Leiomyoma And Ovarian Cyst With Homoeopathic Medicine Thuja Occidentalis: An Evidence-Based Case Report, Bharti Wadhwa, Sujata Madhukar, Shweta Singh Kureel

Indian Journal of Research in Homoeopathy

Introduction: Leiomyoma (Uterine Fibroid [UF]) is the most prevalent benign solid tumour arising from the neoplastic transformation of smooth muscle cells of myometrium in the reproductive age of females. Fibroids are rare before puberty, increase in prevalence during the reproductive years, and usually reduce in size after menopause.

Case Summary: A 34-year-old woman presented with a complaint of hypogastric pain, and heavy bleeding during her menstrual periods since 3–4 months. Her menstrual cycle was irregular. She was diagnosed with an intramural UF and a right ovarian cyst on ultrasonography. Thuja occidentalis (in different potencies) was prescribed based on …

Role Of Individualised Homoeopathic Treatment In A Case Of Secondary Infertility With Uterine Fibroid Treated Through Psychosomatic Approach: A Case Report, Neha Swarup, Mahesh Gupta, Maneesh Mishra, Sanjay Gupta

Indian Journal of Research in Homoeopathy

Introduction: Infertility is the inability of a couple to conceive even after being sexually active for a period of one year. It is a fact that the inability to have one’s own child is a grave concern worldwide. Infertility is a globally prevalent condition, with 8–12% of the world population suffering from it. Infertility in females can be due to several causes, one of them is a uterine anomaly like uterine fibroid. Uterine fibroids are generally considered a structural pathology and mostly managed as a surgical condition. A vast literature review emphasises the importance of psychological factors which can lead …

Uterine Fibroid And Haemorrhagic Ovarian Cyst Treated With Homoeopathic Medicine Sepia Officinalis In Lm Potency: An Evidence-Based Case Report, Karunakara Moorthi, K. R. Siva Tharshini

Indian Journal of Research in Homoeopathy

Introduction: Uterine fibroids are the most common benign neoplasms of the female genital tract in reproductive-age women. The wide range of symptoms includes menorrhagia, metrorrhagia, continuous/post-menopausal bleeding, pain and pressure symptoms. The haemorrhagic ovarian cyst is an adnexal mass which resolves spontaneously by itself but requires surgery if it is more than 5 cm in size. Case Summary: A 46-year-old female patient came to the outpatient department with profuse uterine bleeding during menses lasting approximately 8–10 days and cutting pain in the lower abdomen extending to the back for two years. Magnetic resonance imaging studies showed a uterine fibroid along …

Social Communication Implementable And Applicable Lens: A Framework For Addressing Assessment Of Social Communication, Louise C. Keegan, Jerry K. Hoepner, Leanne Togher, Mary Kennedy, Elise Bogart, Melissa Brunner, Sheila Macdonald

Communication Sciences and Disorders Faculty Articles and Research

Purpose:

Method:

Comparing Sodium Fusidate And Petrolatum For Electrosurgery-Related Wound Healing: A Double-Blind Randomized Controlled Trial, Firman Parrol, Larisa Paramitha Wibawa, Irma Bernadette Simbolon Sitohang, Siti Rizny Fitriana Saldi

Journal of General - Procedural Dermatology and Venereology Indonesia

Background: Electrosurgery is a common surgical technique used to treat skin tumors. This procedure produces necrotic skin, which might impair the wound healing process, prompting physicians to prescribe topical antibiotics to prevent infection. This study aims to analyze the efficacy of sodium fusidate ointment compared to petrolatum for wound healing after electrosurgery.

Methods: We conducted a double-blind, randomized, controlled study with a within-person design. The inclusion criteria were adult subjects with seborrheic keratosis or acrochordon with a size of 4 mm to 10 mm on the face and neck, with a minimum of 2 lesions. Electrodessication was performed on the …

Combination Of 1064 Nm Qs Nd:Yag Photoacoustic Technology And Exosome For Facial Rejuvenation, Stanley Setiawan, Samuel Septrian Putranto, Angela Maria Linata, Stephanie Salim, Novia Sari Andriati Mertosono, Shelly Nobel, Flora Asri Wardianti, Ita Anggraini, Zulaikha Rizqina Rahmawati

Journal of General - Procedural Dermatology and Venereology Indonesia

Background: Facial rejuvenation has become a global trend in cosmetic and aesthetic dermatology to restore youthful skin. The combination of 1064 nm Q-Switched Neodymium:Yttrium Aluminum Garnet (QS Nd:YAG) laser and exosomes as a facial rejuvenation procedure restores youthfulness by increasing collagen and elastin.

Case Illustration: This case series evaluated the effectiveness of 1064 nm QS Nd:YAG laser with and without human amniotic fluid stem cell-derived exosomes (hAFSC-exo) for facial rejuvenation in six adults aged 24–39 years with Fitzpatrick skin types III-IV. Participants were randomized to receive either laser treatment alone or combined with intradermal hAFSC-exo injections every two weeks for …

Skin Rejuvenation With Microbotox: A Review, Ifen Ayu Malinda, Nelva Karmila Jusuf

Journal of General - Procedural Dermatology and Venereology Indonesia

Background: Skin aging is characterized by a gradual loss of tissue and organ function. Skin aging can be classified into two types: intrinsic aging, associated with the aging process itself, and extrinsic aging, which is linked to external factors. Microbotox—an intradermal injection of diluted botulinum toxin—has emerged as a promising technique for rejuvenation by improving skin texture, pore size, and sebum control. This review aims to provide a comprehensive overview of the microbotox technique in the context of skin aging, emphasizing its mechanisms, indications, and clinical outcomes.

Discussion: In Asia, intradermal injection of botulinum toxin or microbotox has been widely …

Unveiling Endoscopic Procedures In Maude: An Etl-Llm Method, Yuheng Shi, Eric Yang, Yang Gong

Faculty, Staff and Student Publications

The increased dependence on patient safety studies using the MAUDE database underscores the critical need to define and standardize the methods for extracting and analyzing event reports. The lack of reproducible methods leads to an inconsistent understanding of reported events and diminishes their effectiveness in informing clinicians. Thus, an ETL pipeline combined with LLMs was proposed to standardize the identification and interpretation of the reports. Using endoscopic clip reports as an example, the ETL-LLM method demonstrates the effectiveness of extracting and analyzing categorical and narrative reports, helping uncover insights related to patient complications, surgical procedures, and device uses. This innovative …

Provision Of Transportation To Psychiatric Follow-Up Appointments, Eliane Sandrine Tueche Fankam

Walden Dissertations and Doctoral Studies

This quality improvement initiative is focused on the lack of transportation as a significant barrier to obtaining health care services for patients with severe psychiatric disorders. Transportation issues remain an important factor that hinders the attainment of health care services by the members of this population. Transportation challenges should be addressed as much as possible for improving healthcare accessibility and providing timely care. Prior to the implementation of the transportation service, only 30% of patients with severe mental illness (SMI) attended their scheduled appointments, demonstrating the need for intervention. This project focused on whether providing transportation services would improve compliance …

Mis-Splicing-Derived Neoantigens And Cognate Tcrs In Splicing Factor Mutant Leukemias, Won Jun Kim, Edie I Crosse, Emma De Neef, Inaki Etxeberria, Erich Y Sabio, Eric Wang, Jan Philipp Bewersdorf, Kuan-Ting Lin, Sydney X Lu, Andrea Belleville, Nina Fox, Cynthia Castro, Pu Zhang, Takeshi Fujino, Jennifer Lewis, Jahan Rahman, Beatrice Zhang, Jacob H Winick, Alexander M Lewis, Robert F Stanley, Susan Dewolf, Brigita Meškauskaitė Urben, Meril Takizawa, Tobias Krause, Henrik Molina, Ronan Chaligne, Priya Koppikar, Jeffrey Molldrem, Mathieu Gigoux, Taha Merghoub, Anthony Daniyan, Smita S Chandran, Benjamin D Greenbaum, Christopher A Klebanoff, Robert K Bradley, Omar Abdel-Wahab

Faculty, Staff and Student Publications

Mutations in RNA splicing factors are prevalent across cancers and generate recurrently mis-spliced mRNA isoforms. Here we identified a series of bona fide neoantigens translated from highly stereotyped splicing alterations promoted by neomorphic, leukemia-associated somatic splicing machinery mutations. We utilized feature-barcoded peptide-MHC dextramers to isolate neoantigen-reactive T cell receptors (TCRs) from healthy donors, patients with active myeloid malignancy, and following curative allogeneic stem cell transplant. Neoantigen-reactive CD8+ T cells were present in the blood of patients with active cancer and had a distinct phenotype from virus-reactive T cells with evidence of impaired cytotoxic function. T cells engineered with TCRs recognizing …

Visualizing Data For Diabetes Management In Patient Portals, Eric Yang, Lakeidra Salazar, Usha Rijal, Yang Gong

Faculty, Staff and Student Publications

Effectively managing diabetes requires active patient engagement in monitoring crucial health metrics, such as HbA1c and glucose levels. However, many existing patient portals present this information in complex and confusing formats, hindering understanding and communication. This study established a prototype for a user-centered dashboard for diabetes management, designed to enhance patient comprehension and interaction with their health data by utilizing principles of relational data display. By applying Gestalt principles and theories of distributed representation, our dashboard optimizes data visualization through Google Looker Studio, ultimately reducing cognitive load and aiding patients in self-management. The findings emphasize the benefits of user-friendly and …

Encorafenib, Cetuximab, And Mfolfox6 In Braf-Mutated Colorectal Cancer, Elena Elez, Takayuki Yoshino, Lin Shen, Sara Lonardi, Eric Van Cutsem, Cathy Eng, Tae Won Kim, Harpreet Singh Wasan, Jayesh Desai, Fortunato Ciardiello, Rona Yaeger, Timothy S Maughan, Van K Morris, Christina Wu, Tiziana Usari, Robert Laliberte, Samuel S Dychter, Xiaosong Zhang, Josep Tabernero, Scott Kopetz, Breakwater Trial Investigators

Faculty, Staff and Student Publications

Background: First-line treatment with encorafenib plus cetuximab (EC) with or without chemotherapy (oxaliplatin, leucovorin, and fluorouracil [mFOLFOX6]) for BRAF V600E-mutated metastatic colorectal cancer, an aggressive subtype with a poor prognosis, was compared with standard care (chemotherapy with or without bevacizumab) in an open-label, phase 3 trial, which showed significance regarding one of the two primary end points, objective response according to blinded independent central review (odds ratio for EC+mFOLFOX6 vs. standard care, 2.44; one-sided P< 0.001). This result led to accelerated Food and Drug Administration approval of this investigational combination therapy for BRAF V600E-mutated metastatic colorectal cancer, including as first-line therapy. Data on progression-free survival (the second primary end point) and an updated interim analysis of overall …

Physical Activity And Functional Mobility In Adults With Hearing Loss: A Series Of Embedded Studies Within A 6-Month Clinical Trial With Hearing Aids, Sarah L. Bochat

USF Tampa Graduate Theses and Dissertations

Adults with hearing loss engage in low levels of physical activity and demonstrate poor performance on measures of functional mobility. The impact of hearing rehabilitation on these outcomes is not fully understood. Previous investigations were largely quantitative and focused on older adults ≥ 65 years of age who may respond differently to hearing intervention than relatively younger adults. They also tended to focus on exercise rather than global engagement in physical activities and did not report hours of hearing aid use, an important indicator of intervention success. One purpose of this dissertation was to determine the feasibility of collecting accelerometry-assessed …

Let's Chat About Spoken Discourse: A Tutorial To Support Use Of Spoken Discourse Analysis When Providing Aphasia Clinical Services., Manaswita Dutta, Laura L. Murray, Hyejin Park, Elizabeth Burklow, Arpita Bose, Hana Kim, Kathryn Greenslade, Amy E. Ramage, Collean Combs, Anusha Balasubramanian, Marianne Casilio

Speech and Hearing Sciences Faculty Publications and Presentations

Spoken discourse is integral to everyday communication; improving discourse outcomes is a primary goal for individuals with aphasia and their families. Consequently, the application of discourse analysis in aphasia assessment and treatment has gained increasing attention in both research and clinical settings. Despite its recognized value among researchers and clinicians, several barriers-such as limited time, inadequate training, and lack of resources-continue to impede the widespread use of discourse analysis into clinical practice. To facilitate its broader adoption, speech-language pathologists require access to comprehensive resources that include information on discourse tasks, outcome measures, psychometric properties, and practical examples of how to …

Pneumococcal Colonization Dynamics Among Young Children With And Without Respiratory Symptoms During The First Year Of The Sars-Cov-2 Pandemic., Liset Olarte, Brian R. Lee, Dithi Banerjee, Douglas Swanson, Christopher J. Harrison, Rangaraj Selvarangan

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: Non-pharmaceutical interventions to mitigate the spread of SARS-CoV-2 were implemented across the United States in 2020. These public health measures might influence pneumococcal colonization in younger children and their subsequent risk of invasive pneumococcal disease. Our objective was to evaluate pneumococcal colonization rates in children ≤ 5 years of age with and without respiratory symptoms during the first 12 months of SARS-CoV-2 pandemic (April 2020 - March 2021).

STUDY DESIGN: This is a retrospective cross-sectional study evaluating pneumococcal colonization rates, density and serotype distribution across three study periods (April-July [Period 1], August-November [Period 2] and December-March [Period 3]) after …

Associations Between Daytime Sleepiness, Obesity, And Sleep Apnea Severity Among Caribbean Women, Melaine F. Mcleod

Walden Dissertations and Doctoral Studies

Obstructive sleep apnea is the most common type of sleep-disordered breathing. Obstructive sleep apnea (OSA) is a global health epidemic that is associated with the obesity pandemic and daytime sleepiness. This quantitative cross-sectional descriptive study aimed to examine associations between daytime sleepiness measured by the Epworth Sleepiness Scale, obesity measured by body mass index (BMI), and severity of OSA measured by the apnea-hypopnea index among Caribbean women residing in the Cayman Islands. The health belief model served as the theoretical framework to guide this research. Daytime sleepiness and obesity were independent variables; the dependent variable was the severity of OSA, …

Contrast Enhancement, G-Cimp Subtype, And Cdkn2a/B Homozygous Deletion In Idh-Mutant Astrocytoma, Mehak Majid Khan, Wenyin Shi, Iyad Alnahhas

Department of Neurology Faculty Papers

No abstract provided.

Evaluating Patient Readiness For Spine Surgery: A Cross-Sectional Study, Lindsay D. Orosz

Doctoral Dissertations and Projects

Spinal conditions effect millions of Americans each year and surgery for these conditions continues to be on the rise. Historically, spine surgery was associated with negative outcomes and fear, often considered a last resort by both patients and physicians. In the last 20 years, spine surgery has become one of the most rapidly advancing surgical fields and is at the forefront of technological advances and ongoing innovation. Today, spine patients have minimally invasive options that are performed in under half the time and are associated with less muscle weakening and adjacent level irritation, as well as more reliable spinal alignment …

Evaluating The Utilization Of Icd-10 Z-Codes For Documenting Social Determinants Of Health And The Association With Frequent Emergency Department Visits Among Medicaid Beneficiaries, Sofia L. Gomez

Doctoral Dissertations and Projects

This study assesses the use of ICD-10 Z-codes for documenting social determinants of health (SDoH) and examines their relationship with frequent emergency department (ED) visits among Arizona Medicaid-eligible beneficiaries. This retrospective cohort study utilizes claims data from a major Arizona Medicaid payor to explore the frequency of ICD-10 Z-codes use for documenting SDoH, associations between variables, and factors most strongly linked to higher ED utilization. The study sample (N = 53,368) includes Medicaid beneficiaries with ED visits in 2023, including 47,153 individuals without documented SDoH and 6,215 individuals with documented SDoH. Descriptive and statistical analyses, such as binomial tests, chi-square …

Implementation Of An Education Program For A Ptsd Screening Tool To Increase Knowledge Among Providers Within The Primary Care Setting, Kimberly Inez Schat

Doctoral Dissertations and Projects

Post-Traumatic Stress Disorder (PTSD) is frequently underdiagnosed or misdiagnosed in primary care settings, leading to delays in treatment and poorer patient outcomes. This scholarly project aims to enhance primary care providers' knowledge and application of PTSD screening tools, specifically the PC-PTSD-5, through a structured educational intervention. The project follows a quasi-experimental pre-test/post-test design, assessing providers' baseline knowledge, delivering targeted education, and measuring changes in knowledge and confidence post-intervention.

Data analysis revealed a statistically significant improvement in providers' ability to identify PTSD symptoms, utilize appropriate screening tools, and refer patients for timely treatment. The project highlights the clinical significance of routine …

Secondary Youth-Level Mechanisms Of Change In Parent Training For Anxious Youth, Jacey L Anderberg, Kelly Barry, Blake M Upshaw, Katie H Mangen, Samuel D Spencer, Andrew G Guzick, Daphne M Ayton, Amanda D Palo, Abigail E Candelari, Eric A Storch

Faculty, Staff and Students Publications

Background: Parent-focused treatments are a promising approach for addressing youth anxiety outside of traditional therapist-delivered modalities. Supportive Parenting for Anxious Childhood Emotions (SPACE) has preliminarily demonstrated efficacy for reducing family accommodation (FA), a key treatment outcome for youth anxiety.

Objective: Since the mechanisms of SPACE remain relatively understudied, we examined youth-reported distress tolerance (DT), anxiety sensitivity (AS), and negative automatic thoughts as candidate mechanisms of SPACE using data from a previously conducted clinical trial.

Methods: In a sample of N = 68 youth (M age = 10.2; 52% male; 62% White), we examined: (a) associations among candidate mechanisms and …

Impact Of Optimal Medical Therapy In Heart Failure Certification For Hospitalists On Guideline-Directed Medical Therapy Utilization, Farhan Ishaq, Duc T Nguyen, Edward A Graviss, Ebun Ebunlomo, Arvind Bhimaraj, Nadia Fida

Faculty, Staff and Students Publications

Background: Significant gaps in guideline-directed medical therapy (GDMT) for heart failure (HF) stem from shortages of cardiologists and advanced HF providers, as well as a lack of optimal HF management knowledge among hospitalists. This study compared the impact of optimal medical therapy in HF (OMT-HF) certification on GDMT implementation and patient outcomes between an intervention group (IG) of hospitalists and a standard-of-care comparison group (SOC-CG).

Aim: To evaluate if OMT-HF has a difference in GDMT and patients in outcomes between IG and SOC-CG.

Methods: This study was implemented from November 2022 to May 2023. Hospitalized cardiology patients with HF and …

Decreasing Medication Errors Among Unlicensed Assistive Personnel, Tamara J. Carroll

Doctoral Dissertations and Projects

Unlicensed assistive personnel, although their role is controversial, are present in many different settings and have many varying roles and job responsibilities. Yet, removing this type of healthcare worker from the job pool may lead to increased labor costs, which could be stifling to some organizations and facilities. Digging deeper, data suggests errors are due to lack of a defined scope of practice, a lack of understanding of job roles and responsibilities and decreased confidence when working in the healthcare setting. The purpose of this project utilizes a setting specific educational intervention and skills check off to increase job self-efficacy …

Cultural And Structural Barriers Influencing The Mental-Health-Seeking Behaviors Of South Asians In Dallas, Texas, Judith Jose

Walden Dissertations and Doctoral Studies

Despite being one of the fastest growing immigrant populations in the United States, South Asians experience disproportionately high rates of untreated mental health conditions while reporting low utilization of professional mental health services. This qualitative phenomenological study explored the cultural and structural barriers that influence mental-health-seeking behaviors among South Asians residing in Dallas, Texas. Guided by the health belief model and principles of cultural competency, this research investigated how perceived susceptibility, severity, benefits, barriers, cues to action, and self-efficacy intersect with cultural stigma, religious beliefs, generational dynamics, and systemic obstacles. Semistructured interviews with 12 South Asian adults revealed seven major …

A Case Of Class Iii Malocclusion With Obstructive Sleep Apnea Treated By Orthodontic Treatment Combined Two-Jaw Orthognathic Surgery, Chao-Yu Lu, Yu-Feng Chen, Yu-Chuan Tseng

Taiwanese Journal of Orthodontics

This case report presents a successful treatment outcome of a 24-year-old male patient who was diagnosed with moderate type of obstructive sleep apnea (OSA) (AHI, 22.8). Cephalometric analysis demonstrates skeletal Class III jaw relation with mandibular prognathism, hyperdivergent facial pattern, Angle’s Class III malocclusion, and anterior cross-bite. Treatment intervention included orthodontic treatment combined with two-jaw orthognathic surgery and genioglossus advancement (GGA). In total treatment period of 14 months, the patient was satisfied with not only the improvement of facial profile and occlusion, but also his sleep quality.

Orthodontic Management Of Angle Class I Malocclusion With Unilateral Mandibular First Molar Loss And Generalized Gingival Recession, Ming-Che Wu, Hsin-Yi Lo, Ming-Ju Lee

Taiwanese Journal of Orthodontics

This case report presents the treatment of Angle Class I malocclusion in a 28-year-old female patient with a missing right mandibular first molar and generalized gingival recession. The treatment plan involved whole-arch distalization in the upper dentition, relief of crowding under the condition of pre-existing gingival recession, space closure of the right mandibular first molar area, with substitution of teeth 47 and 48 for better final occlusion. Anchorage strategies included sequential distalization of upper buccal segment with the aid of temporary anchorage devices before anterior alignment. The closure of the right mandibular first molar space was achieved with uprighting and …

Moving A Maxillary Incisor Across The Midline For Substitution Of Contralateral Missing Incisor In A Multiple Anterior Teeth Missing Patient, Ling-Yu Huang, Chun-Liang Kuo, Chun-Hsiu Yang, Ting-Wei Liu

Taiwanese Journal of Orthodontics

Loss of permanent maxillary incisor causes a significant esthetic problem, and there are various treatment options for rehabilitation. Moving the contralateral tooth across the facial midline for substitution of missing tooth is a possible treatment alternative for closing the maxillary anterior space.

This report presents an unusual treatment for a bimaxillary protrusion patient who typically requires premolar extraction to improve the convex profile. However, due to multiple missing anterior teeth, the left maxillary central incisor was moved across the facial midline to substitute the absent contralateral tooth, resulting in an improved profile after treatment.

The case was an 18-year-old female …