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2025

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Full-Text Articles in Medicine and Health Sciences

Associations Between Health-Seeking Behaviors And Social Support For Adult Black Women In The United States, Patricia Saint Cyr-Hager Dec 2025

Associations Between Health-Seeking Behaviors And Social Support For Adult Black Women In The United States, Patricia Saint Cyr-Hager

Walden Dissertations and Doctoral Studies

A persistent gap exists involving health outcomes for Black women in the United States, regardless of socioeconomic status when compared to Black men and White women. This qualitative case study involved exploring the influence of social support on health-seeking behaviors among Black women. Sixteen participants, between ages 22 to 49 from nine states, were recruited. Data was collected using semi-structured interviews based on the social support theory. An analysis of the network composition showed that family members (including mothers, fathers, sisters, and partners), friends, community support groups not connected to social media, and online community support groups were the most …


The Association Between E-Cigarette Use And Community Mattering Among Adolescents In Maine, April Hughes Dec 2025

The Association Between E-Cigarette Use And Community Mattering Among Adolescents In Maine, April Hughes

Walden Dissertations and Doctoral Studies

E-cigarette use among U.S. high school students is a significant public health issue. Factors such as mattering, sexual orientation, and gender identity (SOGI) influence e-cigarette use among adolescents, yet few studies have explored the relationship between mattering and e-cigarette use when considering SOGI. This quantitative study explored the association between past 30-day e-cigarette use and mattering among Maine high schoolers while controlling for SOGI and grade level. This correlational cross-sectional study used the 2023 Maine Integrated Youth Health Survey data, and the socioecological model served as the theoretical foundation. A multivariate binary logistic regression analysis indicated a significant association between …


Investigation On The Effects Of Hypoxia-Mimicking Agents In Cancer Progression And Oxidative Stress In Hepatocellular Carcinoma, June Wong Xin Ni Dec 2025

Investigation On The Effects Of Hypoxia-Mimicking Agents In Cancer Progression And Oxidative Stress In Hepatocellular Carcinoma, June Wong Xin Ni

Student Works (2020-2029)

Hypoxia, or oxygen deprivation, is a common pathological feature found in hepatocellular carcinoma (HCC). Hypoxia-inducible factor (HIF) is the master transcription factor of oxygen homeostasis, eliciting a wide range of cellular adaptive responses to either enhance oxygen delivery or reduce oxygen consumption. HIF is primarily regulated by two types of oxygen sensors, the prolyl hydroxylase domain-containing proteins (PHDs) and factor-inhibiting HIF (FIH). In tumours, HIF functions as a double-edged sword whereby it could either promote or hinder tumour progression. This is mainly contributed by the pleiotropic nature of hypoxia and tumour heterogeneity. Recently, there is a growing interest in the …


Gut Microbiome Metagenomics In Clinical Practice: Bridging The Gap Between Research And Precision Medicine, Henok Ayalew Tegegne, Tor C Savidge Dec 2025

Gut Microbiome Metagenomics In Clinical Practice: Bridging The Gap Between Research And Precision Medicine, Henok Ayalew Tegegne, Tor C Savidge

Faculty, Staff and Students Publications

Gut microbiome metagenomics is emerging as a cornerstone of precision medicine, offering exceptional opportunities for improved diagnostics, risk stratification, and therapeutic development. Advances in high-throughput sequencing have uncovered robust microbial signatures linked to infectious, inflammatory, metabolic, and neoplastic diseases. Clinical applications now include pathogen detection, antimicrobial resistance profiling, microbiota-based therapies, and enterotype-guided patient stratification. However, translation into routine care is hindered by significant barriers including methodological variability, limited functional annotation, lack of bioinformatics standardization, and underrepresentation of global populations. This review synthesizes current translational strategies, emphasizing the need for hypothesis-driven designs, multi-omic integration, longitudinal and multi-center cohorts, and mechanistic validation. …


Nutrition Support Adequacy In Children With Biliary Atresia After Liver Transplant, Nicole Knebusch, Manpreet Virk, Moreshwar S Desai, Marwa Mansour, Stacey Beer, Brittany Pearo, Kelby Fuller, Krupa Mysore, John Goss, Thomas Fogarty, Fernando Stein, Jorge A Coss-Bu Dec 2025

Nutrition Support Adequacy In Children With Biliary Atresia After Liver Transplant, Nicole Knebusch, Manpreet Virk, Moreshwar S Desai, Marwa Mansour, Stacey Beer, Brittany Pearo, Kelby Fuller, Krupa Mysore, John Goss, Thomas Fogarty, Fernando Stein, Jorge A Coss-Bu

Faculty, Staff and Students Publications

No abstract provided.


An Integrated Platform For Concurrent Structural And Single-Nucleotide Variants Improves Copy-Number Detection And Reveals Pathogenic Alleles In Undiagnosed Mendelian Families, Haowei Du, Ming Yin Lun, Lidiia Gagarina, Jesse D Bengtsson, Christopher M Grochowski, Michele G Mehaffey, James Paul Hwang, Shalini N Jhangiani, Sravya V Bhamidipati, Donna M Muzny, M Cecilia Poli, Sebastian Ochoa, Ivan K Chinn, Anna Lindstrand, Jennifer E Posey, Richard A Gibbs, Pengfei Liu, James R Lupski, Claudia M B Carvalho Dec 2025

An Integrated Platform For Concurrent Structural And Single-Nucleotide Variants Improves Copy-Number Detection And Reveals Pathogenic Alleles In Undiagnosed Mendelian Families, Haowei Du, Ming Yin Lun, Lidiia Gagarina, Jesse D Bengtsson, Christopher M Grochowski, Michele G Mehaffey, James Paul Hwang, Shalini N Jhangiani, Sravya V Bhamidipati, Donna M Muzny, M Cecilia Poli, Sebastian Ochoa, Ivan K Chinn, Anna Lindstrand, Jennifer E Posey, Richard A Gibbs, Pengfei Liu, James R Lupski, Claudia M B Carvalho

Faculty, Staff and Students Publications

Background: Copy number variation (CNV) is a class of genomic structural variation (SV) that contributes to genomic disorders and can significantly impact health. Short-read genome sequencing (sr-GS) enables genome-wide SV calling which has been shown to increase diagnosis in unsolved rare disease families. The growing number of large sequencing cohort projects with sr-GS data available requires open free analytical tools that provide visualization of CNV and SV integrated calls associated with gene annotation, proband-parent trio analysis to enable prioritization of de novo variants, B-allele frequency (BAF) plots to support CNV calls, parent of origin assessment and mosaicism detection.

Methods: To …


Causal Functional Mediation Analysis With An Application To Functional Magnetic Resonance Imaging Data, Yi Zhao, Xi Luo, Michael E Sobel, Martin A Lindquist, Brian S Caffo Dec 2025

Causal Functional Mediation Analysis With An Application To Functional Magnetic Resonance Imaging Data, Yi Zhao, Xi Luo, Michael E Sobel, Martin A Lindquist, Brian S Caffo

Faculty, Staff and Student Publications

A primary goal of task-based functional magnetic resonance imaging (fMRI) studies is to quantify the effective connectivity between brain regions when stimuli are presented. Assessing the dynamics of effective connectivity has attracted increasing attention. Causal mediation analysis serves as a widely implemented tool aiming to delineate the mechanism between task stimuli and brain activations. However, the case, where the treatment, mediator, and outcome are continuous functions, has not been studied. Causal mediation analysis for functional data is considered. Semiparametric functional linear structural equation models are introduced and causal assumptions are discussed. The proposed models allow for the estimation of individual …


Accelerated Molecular Aging In Neighborhood Poverty: A Racial/Ethnic Comparison, Jennifer Robinette, Jennifer Smith Dec 2025

Accelerated Molecular Aging In Neighborhood Poverty: A Racial/Ethnic Comparison, Jennifer Robinette, Jennifer Smith

Psychology Faculty Articles and Research

In the US, racial/ethnic health disparities are undeniable and partially stem from residing in low SES neighborhoods. Associations between neighborhood SES and health may have some underlying molecular mechanisms reflected in the epigenome. Yet, neighborhood characteristics are not always experienced the same way for all residents, and questions remain regarding whether those most exposed to low SES neighborhoods build greater resilience to, or embody greater harmful and cumulative outcomes from, such neighborhoods. The present study tested the hypothesis that greater neighborhood poverty would relate to accelerated epigenetic aging on the Horvath, Hannum, PhenoAge, and GrimAge clocks, and that these associations …


Disruption Of Protein-Protein Interaction Hotspots In The C-Terminal Domain Of Mlh1 Confers Mismatch Repair Deficiency, Keri M. Fishwick, Diego Gomez Vieito, Giada Greco, Giulio Collotta, Marco Gatti, Anastasija A. Kulik, Raphaël Guérois, Ivan Corbeski, Ashutosh S. Phadte, Issam Senoussi, Petr Cejka, Anna Pluciennik, Antonio Porro, Alessandro A. Sartori Dec 2025

Disruption Of Protein-Protein Interaction Hotspots In The C-Terminal Domain Of Mlh1 Confers Mismatch Repair Deficiency, Keri M. Fishwick, Diego Gomez Vieito, Giada Greco, Giulio Collotta, Marco Gatti, Anastasija A. Kulik, Raphaël Guérois, Ivan Corbeski, Ashutosh S. Phadte, Issam Senoussi, Petr Cejka, Anna Pluciennik, Antonio Porro, Alessandro A. Sartori

Department of Biochemistry and Molecular Biology Faculty Papers

MutLα, a heterodimer of MLH1 and PMS2, plays a key role in DNA mismatch repair (MMR), which maintains genomic stability by correcting replication errors. Loss of MLH1 function causes MMR deficiency (MMRd), leading to elevated mutation rates and increased cancer susceptibility. However, MMRd can offer a therapeutic advantage, as high tumour mutational burden enhances the efficacy of immune checkpoint inhibition. MMR also drives somatic expansion of CAG repeats linked to Huntington’s disease (HD) pathogenesis. The C-terminal domain (CTD) of MLH1 contains at least two distinct protein–protein interaction (PPI) sites. The S1 site supports heterodimerization with the PMS2 endonuclease, whereas the …


Intrathoracic Manifestations Of Hematologic Malignancies: A Narrative Review, Kshama Bhyravabhotla, Gregory Gaskey, Jeremy R Walder, Diwakar D Balachandran, Sujith V Cherian, Bilal Zafar, Lara Bashoura, Ajay Sheshadri, Saadia A Faiz Dec 2025

Intrathoracic Manifestations Of Hematologic Malignancies: A Narrative Review, Kshama Bhyravabhotla, Gregory Gaskey, Jeremy R Walder, Diwakar D Balachandran, Sujith V Cherian, Bilal Zafar, Lara Bashoura, Ajay Sheshadri, Saadia A Faiz

Faculty, Staff and Student Publications

Background and objective: Although the global incidence of hematologic malignancies is decreasing, the risk of developing these cancers is increasing due to increased lifespan and modern treatments including targeted therapy, chemotherapy, and radiation. Intrathoracic manifestations of hematologic malignancies may be the presenting sign leading to diagnosis or result from various treatment toxicity. The most common respiratory manifestation of hematologic malignancies is infectious, but up to half of pulmonary findings are from non-infectious etiologies. We aim to summarize the current literature on non-infectious intrathoracic manifestations of hematologic malignancies and their treatment.

Methods: We performed a literature review using PubMed Central and …


Netrin-1 Promotes Pancreatic Tumorigenesis And Innervation Through Neo1, Hiroki Kobayashi, Yosuke Ochiai, Junya Arai, Masahiro Hata, Feijing Wu, Masaki Sunagawa, Tadashi Iida, Taisuke Baba, Ermanno Malagola, Takayuki Tanaka, Zhengyu Jiang, Ruth A White, Xiaofei Zhi, Jin Qian, Quin T Waterbury, Ruhong Tu, Biyun Zheng, Yi Zeng, Hualong Zheng, Puran Zhang, Shuang Li, Leah B Zamechek, Jonathan S Labella, Takahiro Sugie, Atsushi Enomoto, Holger K Eltzschig, Carmine F Palermo, Iok In Christine Chio, Kenneth P Olive, Timothy C Wang Dec 2025

Netrin-1 Promotes Pancreatic Tumorigenesis And Innervation Through Neo1, Hiroki Kobayashi, Yosuke Ochiai, Junya Arai, Masahiro Hata, Feijing Wu, Masaki Sunagawa, Tadashi Iida, Taisuke Baba, Ermanno Malagola, Takayuki Tanaka, Zhengyu Jiang, Ruth A White, Xiaofei Zhi, Jin Qian, Quin T Waterbury, Ruhong Tu, Biyun Zheng, Yi Zeng, Hualong Zheng, Puran Zhang, Shuang Li, Leah B Zamechek, Jonathan S Labella, Takahiro Sugie, Atsushi Enomoto, Holger K Eltzschig, Carmine F Palermo, Iok In Christine Chio, Kenneth P Olive, Timothy C Wang

Faculty, Staff and Student Publications

Nerves can regulate tumorigenesis and cancer progression. However, clarification of the role of axon guidance molecules in tumorigenesis, innervation, and metastasis is required to better understand the tumor-promoting functions of nerves. Using murine KrasG12D-mutant pancreatic organoids, we screened axon guidance molecules and identified netrin-1 upregulation. Netrin-1 was also upregulated in vivo during pancreatic tumorigenesis in humans and mice. Mutant KRAS and β-adrenergic signaling upregulated netrin-1 and its receptor NEO1 in epithelial cells in part through the MAPK pathway. Ex vivo culture of celiac ganglia showed that netrin-1 promoted the axonogenesis of sympathetic neurons through nerve NEO1. In the Pdx1-Cre;LSL-KrasG12D/+ model, …


Speeding Up Interval Estimation For R2-Based Mediation Effect Of High-Dimensional Mediators Via Cross-Fitting, Zhichao Xu, Chunlin Li, Sunyi Chi, Tianzhong Yang, Peng Wei Dec 2025

Speeding Up Interval Estimation For R2-Based Mediation Effect Of High-Dimensional Mediators Via Cross-Fitting, Zhichao Xu, Chunlin Li, Sunyi Chi, Tianzhong Yang, Peng Wei

Faculty, Staff and Student Publications

Mediation analysis is a useful tool in investigating how molecular phenotypes such as gene expression mediate the effect of exposure on health outcomes. However, commonly used mean-based total mediation effect measures may suffer from cancellation of component-wise mediation effects in opposite directions in the presence of high-dimensional omics mediators. To overcome this limitation, we recently proposed a variance-based R-squared total mediation effect measure that relies on the computationally intensive nonparametric bootstrap for confidence interval estimation. In the work described herein, we formulated a more efficient two-stage, cross-fitted estimation procedure for the R2 measure. To avoid potential bias, we performed …


Food Apartheid And The Retail Food Environment In The Bronx, Aissatou Barry Dec 2025

Food Apartheid And The Retail Food Environment In The Bronx, Aissatou Barry

CUNY Mexican Studies Institute

This project examines the structural mechanisms that contribute to unequal food access, both historical and ongoing, in the South Bronx, and applies the food apartheid framework created by Bronx food activist Karen Washington. This paper applies the framework to two food retail initiatives in NYC: the New York State Regional Hub and the New York City FRESH food program to assess whether their policies address the structural mechanisms that contribute to food inequality. I ask: How does the unequal distribution of healthy food access in the Bronx reflect broader patterns of racial and economic exclusion? To what extent do current …


Uji Kelayakan Teknis Dan Performa Auvest: Rompi Pendingin Otomatis Berbasis Wearable Thermoelectric Cooler Untuk Mitigasi Risiko Heat Stress, Muchammad Adam Wildan, Amelia Avril Rayhana, Nadia Hanifan Nabila, Bian Shabri Putri Irwanto Dec 2025

Uji Kelayakan Teknis Dan Performa Auvest: Rompi Pendingin Otomatis Berbasis Wearable Thermoelectric Cooler Untuk Mitigasi Risiko Heat Stress, Muchammad Adam Wildan, Amelia Avril Rayhana, Nadia Hanifan Nabila, Bian Shabri Putri Irwanto

National Journal of Occupational Health and Safety

Heat stress is a serious threat to construction workers that can reduce productivity and even threaten lives. Existing cooling vest innovations still have limitations, such as weight, manual systems, and the risk of leakage. This study aims to analyze the effectiveness of the Automatic Vest (AUVEST), an automatic cooling vest based on Wearable Thermoelectric Cooler and the Internet of Things (IoT), in preventing the risk of heat stress. The method used is experimental with trials on one construction worker in indoor and outdoor environments. AUVEST is equipped with temperature sensors (DS18B20, TMP102) and humidity (DHT11), whose data is processed by …


Global Preferences And Determinant Variables Of Caesarean Delivery Among Pregnant Women: A Systematic Review And Meta-Analysis, Mitiku Tefera, Lijalem Jemberu, Eyob Getachew, Getnet Alemu Andarge, Kedir Seid, Gebeyehu Lakew, Amlaku Nigusie Yirsaw, Eyob Ketema Bogale Dec 2025

Global Preferences And Determinant Variables Of Caesarean Delivery Among Pregnant Women: A Systematic Review And Meta-Analysis, Mitiku Tefera, Lijalem Jemberu, Eyob Getachew, Getnet Alemu Andarge, Kedir Seid, Gebeyehu Lakew, Amlaku Nigusie Yirsaw, Eyob Ketema Bogale

Sultan Qaboos University Medical Journal

A caesarean section (CS) is a lifesaving procedure. With rising rates, women’s delivery choices have become a global concern. This review assesses global CS preference and determinants. A search of 6 databases was conducted (PubMed, Medline, EMBASE, CINAHL, Google Scholar and Maternity and Infant Care) in accordance with PRISMA guidelines, including papers published between 2013 and 2024. Egger’s test and funnel plot assessed publication bias, while the I2 statistic and Cochrane Q-test evaluated heterogeneity. Subgroup analysis considered sample size, publication year and economic condition. Initially, 73 articles were identified, of which 13 were deemed suitable, with a total sample size …


Harmonizing Self-Reported And Free Text Medication Data: A Reproducible Pipeline For Gerontological Research, Ramkrishna K Singh, Chen Chen, Semere Bekena, David C Brown, Kaylin Taylor, Matthew Blake, Yiqi Zhu, Kebede Beyene, David B Carr, Ganesh M Babulal Dec 2025

Harmonizing Self-Reported And Free Text Medication Data: A Reproducible Pipeline For Gerontological Research, Ramkrishna K Singh, Chen Chen, Semere Bekena, David C Brown, Kaylin Taylor, Matthew Blake, Yiqi Zhu, Kebede Beyene, David B Carr, Ganesh M Babulal

2020-Current year OA Pubs

BACKGROUND: Self-reported medication data collected as free text in gerontological and dementia research is often unstructured with inconsistent formatting. These circumstances pose a challenge for standardization and classification when preparing effective, reproducible analyses. Spelling variations, naming conventions, and reporting drug combinations can hinder mapping to standard pharmacologic vocabularies and compromise medication exposure assessments. We aimed to develop and implement a transparent, reproducible, and scalable data harmonization pipeline that ingests free-text medication records and classifies them according to American Hospital Formulary Service (AHFS) therapeutic categories. METHODS: A four-phase curation pipeline processed 30,062 Research Electronic Data Capture (REDCap) medication records collected over …


Membrane Il-18 Identifies A Human Macrophage Subset With Distinct Proteomic And Functional Traits, Chiara Vitale, Marco Colonna, Et Al. Dec 2025

Membrane Il-18 Identifies A Human Macrophage Subset With Distinct Proteomic And Functional Traits, Chiara Vitale, Marco Colonna, Et Al.

2020-Current year OA Pubs

This study contributes to the characterization of human macrophages in normal and pathological conditions such as cancer. We characterized a macrophage population expressing membrane-associated IL-18 (mIL-18) that shows peculiar proteomic, phenotypic, ultrastructural, and functional properties. mIL-18+ macrophages exhibit increased levels of key proteins involved in pathogen recognition, activation, migration, and endocytosis. They also display specialized functions in vesicle and actin filament transport and lipid metabolism, and have typical mitochondrial traits. Importantly, mIL-18+ cells dominate the peritoneal fluid of adult cancer patients and are present in the bone marrow of children with neuroblastoma. They express high levels of TREM2 but display …


Us Drug Policy Does Not Align With Experts’ Rankings Of Drug Harms: A Multi-Criteria Decision Analysis, Michael Broman, Alan K Davis, Stacey Armstrong, Adam Levin, Kaltum Ahmed, Gustavo A Angarita, Brooke J Arterberry, Cecilia Bergeria, Mitch Earleywine, Kathryn S Gex, Tom Gregoire, Jamey J Lister, David S Mathai, Nicky J Mehtani, Nathan Menke, Charles D Nichols, Hillary Shaub, Alayna P Tackett, Brandon Weiss, Nefize Yalin, Lawrence D Phillips Dec 2025

Us Drug Policy Does Not Align With Experts’ Rankings Of Drug Harms: A Multi-Criteria Decision Analysis, Michael Broman, Alan K Davis, Stacey Armstrong, Adam Levin, Kaltum Ahmed, Gustavo A Angarita, Brooke J Arterberry, Cecilia Bergeria, Mitch Earleywine, Kathryn S Gex, Tom Gregoire, Jamey J Lister, David S Mathai, Nicky J Mehtani, Nathan Menke, Charles D Nichols, Hillary Shaub, Alayna P Tackett, Brandon Weiss, Nefize Yalin, Lawrence D Phillips

Faculty, Staff and Students Publications

Background: United States drug policy is primarily based on the Controlled Substances Act of 1970 and largely contradicts scientific evidence about how to mitigate drugs’ harms. Expert consensus on drug harms could inform policy that improves the health of people who use drugs while reducing negative societal impacts of drug use. Therefore, this study adapted and extended the relevant 2010 United Kingdom multi-criteria decision analysis, rating drug harms by criteria comprising health and social impacts to people who use drugs and their families, communities, and society.

Methods: Seventeen experts on drug use in the US, including three with lived experience …


Ultrasound-Guided Diffuse Optical Tomography: An Adjunct To Ultrasound That Can Reduce Unnecessary Breast Biopsies, Quing Zhu, Debbie Bennett, Ian S Hagemann, Jaimee Mannix, Kimberly Wiele, Megan Luther, Jingqin Luo, Steven P Poplack Dec 2025

Ultrasound-Guided Diffuse Optical Tomography: An Adjunct To Ultrasound That Can Reduce Unnecessary Breast Biopsies, Quing Zhu, Debbie Bennett, Ian S Hagemann, Jaimee Mannix, Kimberly Wiele, Megan Luther, Jingqin Luo, Steven P Poplack

2020-Current year OA Pubs

BACKGROUND: Breast biopsy is recommended for any lesion in which the radiologist deems the likelihood of malignancy to be greater than 2% and more than 75% of biopsies return with benign results. This study assesses whether the total hemoglobin concentration (HbT) and blood oxygen saturation (%sO2) of malignant and benign breast lesions, obtained using Ultrasound-guided diffuse optical tomography (US-guided DOT), can help reduce benign breast biopsy rates. METHODS: 238 women consecutively recruited were examined with US-guided DOT before their US-guided biopsy. Three or four radiologists independently provided BI-RADS assessments using pre-procedure US and mammography (when available), first without and then …


Eata Mediated Degradation Of Intestinal Mucus Is Species-Specific And Driven By Muc2 Structural Features, Sergio Trillo-Muyo, Brendan Dolan, Frida Svensson, Tim J Vickers, Liisa Arike, Maria-Jose García-Bonete, Jenny K Gustafsson, Mathias I Nielsen, Hans H Wandall, James M Fleckenstein, Gunnar C Hansson, Sjoerd Van Der Post Dec 2025

Eata Mediated Degradation Of Intestinal Mucus Is Species-Specific And Driven By Muc2 Structural Features, Sergio Trillo-Muyo, Brendan Dolan, Frida Svensson, Tim J Vickers, Liisa Arike, Maria-Jose García-Bonete, Jenny K Gustafsson, Mathias I Nielsen, Hans H Wandall, James M Fleckenstein, Gunnar C Hansson, Sjoerd Van Der Post

2020-Current year OA Pubs

Enterotoxigenic Escherichia coli (ETEC) infections are a leading cause of diarrheal illness, responsible for an estimated 100,000 deaths annually. ETEC pathogenesis is driven by various virulence factors, including toxins, adhesins, and noncanonical factors such as the protease EatA. The first line of host defense against intestinal pathogenic bacterial infections is the protective intestinal mucus layer. Here, we demonstrate the mechanism by which EatA degrades the core mucus component MUC2, thereby facilitating access to the epithelial cell surface and promoting infection. We identify the specific cleavage site region localized at the C-terminal of MUC2. EatA's protease activity depends on the interaction …


Clinical Pathway Sebagai Solusi Keberlanjutan Jkn Di Indonesia: Systematic Review, Septiana Septiana, Siti Soekiswati, Burhannudin Ichsan Dec 2025

Clinical Pathway Sebagai Solusi Keberlanjutan Jkn Di Indonesia: Systematic Review, Septiana Septiana, Siti Soekiswati, Burhannudin Ichsan

Jurnal Ekonomi Kesehatan Indonesia

The National Health Insurance (JKN) program is threatened with a deficit and potential default in 2026 due to inefficiency and the risk of fraud in healthcare facilities. In the context of JKN, which uses a package system (INA-CBG), Clinical Pathway (CP) is a strategic instrument within the JKN system that has dual benefits for both Payers (BPJS Kesehatan) and Providers (Hospitals). For BPJS Kesehatan, CP primarily functions to ensure service quality and prevent undertreatment fraud, the practice of reducing services to benefit hospitals. This prevention ultimately achieves cost efficiency in the JKN program by avoiding payment of complication claims and …


Evaluation Of Chicken Serum And Chicken Egg Yolk As Novel Supplements For The In Vitro Cultivation Of Mycoplasma Hyorhinis, Yi-Chia Li, Sin-Hang Ma, Wei-Hao Lin, Chao-Nan Lin, Ming-Tang Chiou Dec 2025

Evaluation Of Chicken Serum And Chicken Egg Yolk As Novel Supplements For The In Vitro Cultivation Of Mycoplasma Hyorhinis, Yi-Chia Li, Sin-Hang Ma, Wei-Hao Lin, Chao-Nan Lin, Ming-Tang Chiou

The Thai Journal of Veterinary Medicine

Mycoplasma hyorhinis is a significant pathogen in swine, yet its fastidious nutritional requirements present challenges for in vitro cultivation. Conventional supplements like horse serum (HS) often suffer from batch variability and potential inhibitors. This study aimed to evaluate chicken serum (CS) and chicken egg yolk (CY) as novel alternatives to develop a reliable cultivation method for M. hyorhinis. Five clinical isolates were cultured for 10 days in a basal medium supplemented with CS or CY at 10%, 20%, or 30%, with 30% HS as the control. Growth was quantified daily using a Color Changing Unit (CCU) assay. CS supported …


Feasibility Of Computed Tomography For Differentiating Calcium Oxalate And Struvite Calculi Using Mean Hounsfield Unit And Hounsfield Density, Somchin Sutthigran, Phasamon Saisawart, Vachira Hunprasit, Nan Choisunirachon, Kiatpichet Komin Dec 2025

Feasibility Of Computed Tomography For Differentiating Calcium Oxalate And Struvite Calculi Using Mean Hounsfield Unit And Hounsfield Density, Somchin Sutthigran, Phasamon Saisawart, Vachira Hunprasit, Nan Choisunirachon, Kiatpichet Komin

The Thai Journal of Veterinary Medicine

Accurate preoperative prediction of cystic calculi composition is essential for effective treatment planning in dogs. This prospective study aims to investigate the utility of non-contrast multi-detector computed tomography (MDCT) in differentiating calcium oxalate (CaOx) and struvite calculi based on mean Hounsfield unit (HU) and HU density values. Nineteen client-owned dogs with confirmed cystic calculi underwent non-contrast MDCT imaging at 80 and 120 kilovoltage peak (kVp) settings prior to surgical removal. Calculi composition was determined via laboratory analysis. Mean HU and HU density were measured and compared between calculi types. The results showed CaOx calculi demonstrated significantly higher mean HU (1317.53 …


Association Of Aerobic Performance With Balance, Anaerobic Power, Agility, And Visual Reaction Time In Fencers, Aysel Gökçe Kurt, Manolya Acar Dec 2025

Association Of Aerobic Performance With Balance, Anaerobic Power, Agility, And Visual Reaction Time In Fencers, Aysel Gökçe Kurt, Manolya Acar

Baltic Journal of Health and Physical Activity

Background: The study aimed to investigate the effects of aerobic performance on balance, anaerobic power, agility, and visual reaction in fencers and was designed as a prospective cohort study. Materials and methods: This study involved 26 fencing athletes (age = 20.35 ± 5.12 years, sports experience: 8.44 ± 4.33 years). The 20-m shuttle test, the vertical jump test, the Y-balance test, the fencing-specific 4-2-2-4 forward-back step method, and the Nelson hand reaction test were used to evaluate aerobic performance, anaerobic performance, balance, agility-change of direction, and visual reaction, respectively. Results: The maximum oxygen consumption determined with a use of the …


Electrochemical Sensors Based On Graphene Oxide/Pedot:Pss Composite Decorated With Bimetallic Gold–Silver Nanoparticles For H2o2 Detection, Rayyan Azzahra Hidayat, Budi Riza Putra, Munawar Khalil, Wulan Tri Wahyuni Dec 2025

Electrochemical Sensors Based On Graphene Oxide/Pedot:Pss Composite Decorated With Bimetallic Gold–Silver Nanoparticles For H2o2 Detection, Rayyan Azzahra Hidayat, Budi Riza Putra, Munawar Khalil, Wulan Tri Wahyuni

Makara Journal of Science

Hydrogen peroxide (H2O2) is a biomarker that indicates oxidative stress levels in the human body; thus, rapid and accurate detection methods are necessary to diagnose various disorders. This study developed a nonenzymatic electrochemical sensor for detecting H2O2 using bimetallic gold–silver nanoparticles (Au–Ag NPs) combined with graphene oxide and poly(3,4-ethylenedioxythiophene)-poly(styrenesulfonate)-modified glassy carbon electrode. The surface properties of the modified electrodes were characterized using scanning electron microscopy–energy dispersive spectroscopy and atomic force microscopy. The electrochemical performance of the modified electrodes was evaluated using cyclic voltammetry, electrochemical impedance spectroscopy, and differential pulse voltammetry. The bimetallic Au-Ag …


Analisis Faktor Yang Berhubungan Dengan Pemberian Vaksinasi Polio Pada Anak Usia 0 - 59 Bulan Di Wilayah Cakupan Vaksinasi Tinggi (Dki Jakarta) Dan Rendah (Di. Yogyakarta), Mayla S. Zahrie, Zakianis Zakianis, Budi Haryanto, Yulia Fitria Ningrum Dec 2025

Analisis Faktor Yang Berhubungan Dengan Pemberian Vaksinasi Polio Pada Anak Usia 0 - 59 Bulan Di Wilayah Cakupan Vaksinasi Tinggi (Dki Jakarta) Dan Rendah (Di. Yogyakarta), Mayla S. Zahrie, Zakianis Zakianis, Budi Haryanto, Yulia Fitria Ningrum

Jurnal Nasional Kesehatan Lingkungan Global

Polio vaccination coverage in Indonesia was uneven across provinces. Based on data from the 2017 Indonesian Health Profile, the coverage of complete oral polio vaccination for infants in Indonesia reached 91,7%, while polio injection vaccination reached only 46,8%. DKI Jakarta was one of the regions with high oral polio vaccination coverage (101.7%), whereas DI Yogyakarta was among the regions with low oral polio vaccination coverage (73.3%). This study aimed to determine the factors associated with polio vaccination among children under five years old in DKI Jakarta and DI Yogyakarta in 2017 using IDHS data from 2017. The study used a …


Analisis Spasial Sebaran Kejadian Diare Berdasarkan Faktor Iklim Di Kota Batam Tahun 2020-2023, Syofetim Esther Novi Triyanti Dec 2025

Analisis Spasial Sebaran Kejadian Diare Berdasarkan Faktor Iklim Di Kota Batam Tahun 2020-2023, Syofetim Esther Novi Triyanti

Jurnal Nasional Kesehatan Lingkungan Global

Diarrhea is the leading cause of morbidity in coastal regions. Batam City is highly vulnerable to climate change. This study aims to analyze the relationship between rainfall, air humidity, population density, safe drinking water facilities, and access to latrines with the incidence of diarrhea and the spatial distribution based on climate factors in Batam City from 2020 to 2023. The study used an ecological study design with subdistricts as the unit of analysis. Aggregate secondary data were obtained from the Batam City Public Health Office, Statistics Indonesia (BPS) Batam City, and NASA POWER. The analysis of the data included univariate …


For Evidence-Based Suicide Risk Assessment, Monica Molah Dec 2025

For Evidence-Based Suicide Risk Assessment, Monica Molah

Walden Dissertations and Doctoral Studies

This clinical practice guideline (CPG) project was developed to address a practice gap regarding the lack of systemic approach to suicide assessment in adult patients. This Doctor of Nursing Practice (DNP) project identified a significant gap in care at a private mental health clinic, which lacked a consistent, evident-based approach to suicide risk assessment. The inconsistency increased the likelihood of under-identifying at risk patients, posing substantial medical-legal and patient safety concerns. The practice-focused question guiding this project was: Does the evidence support the development of a CPG for suicide risk screening that receives an AGREE II quality score by an …


What Bereaved People Have Found Helpful Following Death Of A Loved One In A Hospital: A Survey Study, Jon Swanson Phd, Mindy Flanagan Phd, Rachel Pfafman Mph, Mba Dec 2025

What Bereaved People Have Found Helpful Following Death Of A Loved One In A Hospital: A Survey Study, Jon Swanson Phd, Mindy Flanagan Phd, Rachel Pfafman Mph, Mba

Other Specialties

Given the individual and public health impact of bereavement, discovering what people perceive as helpful after loss can improve interventions. In contrast to national projects, this project focused on two hospitals in a Midwestern hospital system.

A survey was developed to assess the work of chaplains with next of kin following a death, to assess the awareness and helpfulness of persons and organizations in the community, and to ask what people had done, said, or given that was helpful, or what respondents wished people had done. From a list of 283 people invited to respond, 52 completed the survey.

Survey …


Hubungan Kehamilan Usia Remaja Dengan Kelahiran Prematur Di Rsud Cengkareng Jakarta Barat Tahun 2022: Sebuah Studi Kohort Retrospektif, Anna Triana, Sudarto Ronoatmodjo Dec 2025

Hubungan Kehamilan Usia Remaja Dengan Kelahiran Prematur Di Rsud Cengkareng Jakarta Barat Tahun 2022: Sebuah Studi Kohort Retrospektif, Anna Triana, Sudarto Ronoatmodjo

Jurnal Epidemiologi Kesehatan Indonesia

Premature birth is leading causes of neonatal mortality. According to the World Health Organization (WHO), global premature birth rates reached 9.9% in 2020, it’s rising compared to preterm birth rates in 2010. One of the risk factors for preterm birth is the mother's age, which pregnant adolescents are more at risk of giving birth to preterm babies due to physiological, psychological, and socioeconomic immaturity. This study is an analytical study with a retrospective cohort design to determine the relationship between adolescents pregnancy and preterm birth. This study was conducted in Cengkareng General Hospital West Jakarta using patient’s medical record data. …