Medicine and Health Sciences Commons^™

Contemporary Outcomes Of Octa-Nonagenarians With Newly Diagnosed Acute Myeloid Leukemia, Jayastu Senapati, Hagop M Kantarjian, Tapan M Kadia, Jeannot Kekedjian, Gautam Borthakur, Naval Daver, Courtney D Dinardo, Elias Jabbour, Prithviraj Bose, Nicholas J Short, Musa Yilmaz, Nitin Jain, Naveen Pemmaraju, Hussein A Abbas, Ghayas C Issa, Abhishek Maiti, Guillermo Montalban Bravo, Indraneel Deshmukh, Elizabeth Shpall, Partow Kebriaei, Uday Popat, Sanam Loghavi, Beenu Thakral, Guilin Tang, Fadi G Haddad, Yesid Alvarado, Guillermo Garcia Manero, Farhad Ravandi

Faculty, Staff and Student Publications

Background: Octa-nonagenarians with acute myeloid leukemia (AML) represent a high-risk group due to frequently poor performance status, adverse genomics (e.g., TP53 mutations, complex karyotype), a high incidence of secondary AML, and inability to undergo an allogeneic stem cell transplantation. Evaluating their outcomes with modern treatment approaches is important.

Methods: This retrospective study analyzed outcomes of patients ≥80 years old with newly diagnosed AML treated at our center from 2013-2023.

Results: A total of 289 patients (median age, 83 years; range, 80-95 years) were included. Venetoclax containing low-intensity therapy was administered to 107 patients (37.0%). AML subtypes included de novo (123, …

Biological Control Mitigates Spread Of Vector-Borne Plant Pathogens, Kris A.G. Wyckhuys, Yi Zou, David W. Crowder, Evie Adriani, Annabelle B. Albaytar, Marie Joy B. Beltran, Ibtissem Ben Fekih, Carolina Camargo-Gil, Filomena C. Filomena, Lizette Cicero, Yelitza C. Colmenarez, Claudia M. Cuellar-Palacios, Thomas Dubois, Sanford D. Eigenbrode, Frederic Francis, Alberto Fereres, Khalid Haddi, Fathiya M. Khamis, Cécile Le Lann, Anne Le Ralec, Lorena Lopez, Baoqian Lyu, James Montoya-Lerma, Karen Muñoz-Cardenas, Ihsan Nurkomar, Paola A. Palmeros-Suarez, Jermaine D. Perier, Ricardo Ramírez-Romero

All Peer-Reviewed Publications

Diseases caused by vector-borne plant pathogens cause adverse impacts on yield resilience, food security, and farmer livelihoods, which are bound to aggravate under global change. Biological control is routinely discounted as a mitigation strategy for plant diseases, partially due to scarce and inconclusive empirical support. Here, using curated field survey data for 58 persistently or semi-persistently transmitted pathogens, we employ a multi-method approach to assess the role of resident (i.e., naturally occurring) biological control agents in these pathosystems. Our meta-analyses show how in planta pathogen incidence is strongly affected by vector abundance and infectivity. Meanwhile, biological control agent density negatively …

Role Of Immunosuppressive Jnk Pathway In The Tumor Microenvironment Among Tnbc Subtypes In Ibcsg Trial 22–00, Andrea Joaquin Garcia, Takashi Semba, Mattia Rediti, Daniel J Mcgrail, Xuemei Xie, Xiaoping Wang, Dileep R Rampa, David Venet, Laurence Buisseret, Samira Majjaj, Roswitha Kammler, Marco Colleoni, Sherene Loi, Giuseppe Viale, Meredith M Regan, Françoise Rothé, Christos Sotiriou, Naoto T Ueno

Faculty, Staff and Student Publications

Phosphorylation of the JNK (pJNK) protein promotes an immunosuppressive tumor microenvironment (TME), enhancing aggressiveness in inflammatory triple-negative breast cancer (TNBC). This study evaluated the role of JNK signaling using a gene signature. RNA sequencing was performed on 347 TNBC tumors from the phase 3 International Breast Cancer Study Group (IBCSG) 22-00 trial, which evaluated adjuvant low-dose cyclophosphamide and methotrexate (CM). Immune-related tumors were identified by TNBC subtype or tumor-infiltrating lymphocytes (TILs). Associations between JNK and outcomes were analyzed using Cox models. Low pJNK levels were associated with better disease-free survival (DFS) in immune-related tumors. These tumors also had lower Treg …

What Are The Predictors Of Malignancy In Inflammatory Bowel Disease?, Zülal İstemi̇han, Bi̇lger Çavuş, Ali̇ Emre Bardak, Ayşe Merve Kirkoğlu, Cansu Kiziltaş, Rüveyda Si̇lay, İbrahi̇m Volkan Şenkal, Zi̇ya İmanov, Kenan Nuri̇yev, Aynure Rüstemzade, Sezen Genç, Mi̇ne Güllüoğlu, Asli Çi̇fci̇başi Örmeci̇, Kadi̇r Demi̇r, Fati̇h Beşişik, Sabahatti̇n Kaymakoğlu, Fi̇li̇z Akyüz

Turkish Journal of Medical Sciences

Background/aimː This study aims to investigate the prevalence of malignancy in patients with inflammatory bowel disease (IBD) followed up in a tertiary reference center.

Materials and methodsː IBD patients with at least 6 months of follow-up from the gastroenterology clinic between 2000 and 2022 wereevaluated retrospectively in a tertiary center. Patient information was obtained from the patient registration system.

Resultsː There were 697 patients in the study, 320 (45.9%) of these were female. The mean age of the patients at IBD diagnosis was 33.4± 13.1 years. The mean follow-up time was 93.1 ± 64.8 (median 84, IQR (25–75) (36–144)) months. …

Different Local Anesthetic Volumes In Pericapsular Nerve Group Block For Hip Fracture Patients, Yusuf Özgüner, Savaş Altinsoy, Gökçen Kültüroğlu, Sevda Gökçe Gürpinar, Derya Özkan, Jüli̇de Ergi̇l, Erbi̇l Aydin

Turkish Journal of Medical Sciences

Background/aim: The pericapsular nerve group (PENG) block is an effective method for pain management in patients with hip fractures. In our study, we compared three different local anesthetic volumes of the PENG block in patients who underwent surgery for hip fracture.Materials and methodsː Patients who underwent surgery with spinal anesthesia for intertrochanteric femur fractures (60 patients) were divided into three groups based on the volume of local anesthetic administered: Group 1 (20 mL), Group 2 (30 mL), and Group 3 (40 mL). Postoperative patient-controlled analgesia was initiated. Postoperative tramadol consumption, rest and movement pain scores, and the duration of motor …

Factors Affecting Extremity Fracture Risk In Children With Attention Deficit Hyperactivity Disorder, Yüksel Sümeyra Naralan, Esra Demi̇rel

Turkish Journal of Medical Sciences

Background/aim: Attention-Deficit/Hyperactivity Disorder (ADHD) is increasingly recognized not only for its behavioural and cognitive challenges but also for its potential implications in physical health, particularly injury risk. This study aimed to investigate the incidence of extremity fractures among children and adolescents diagnosed with ADHD and to evaluate the influence of demographic, clinical, and pharmacological variables—including ADHD subtypes and medication types—on fracture risk

Materials and Methods: This retrospective cross-sectional study included 754 children and adolescents aged 6–18 years who were diagnosed with ADHD according to DSM-5 criteria. Data were collected from electronic health records at a tertiary referral hospital. Variables …

Blood Group Profile Of Türkiye With Regional And Demographic Differences: A 23-Year Retrospective Study, Levent Sağdur, Azi̇z Karaca, Mustafa Nuri̇ Günçikan, Mustafa Yilmaz, Kerem Kinik

Turkish Journal of Medical Sciences

Background/aim: This study aims to comprehensively analyze the distribution of ABO and Rh blood groups, as well as demographic characteristics and regional variations, using data from 9.5 million blood donors across Türkiye.

Materials and methods: In this multicenter, retrospective, cross-sectional study, data were collected from 9,587,592 healthy, voluntary donors who donated to the Turkish Red Crescent between 1998 and 2021. Donors met the criteria of being 18–70 years old, weighing over 50 kg, with hemoglobin levels above 13.5 g/dL for male and 12.5 g/dL for female. The data were evaluated based on age, gender, education level, and geographic region.

Results: …

Evaluation Of Teachers' Knowledge And Awareness About Autism Spectrum Disorder, Hami̇t Harun Bağci, Abi̇de Aksungur, Gülsüm Öztürk Emi̇ral, Erhan Şi̇mşek

Turkish Journal of Medical Sciences

Background/aim: Teachers play an essential role in the early identification of autism spectrum disorder (ASD) and associated difficulties in children. Increasing teachers’ knowledge of ASD can be helpful in identifying these children and making the necessary referrals. This study aimed to assess teachers’ knowledge and awareness of ASD and the factors affecting them.

Materials and methods: This is a cross-sectional study conducted among school counsellors. A total of 171 school counsellors were contacted; school visits were arranged by prior appointment, and the purpose of the study was explained. Data were collected using a questionnaire prepared by the researchers and the …

Comparison Of Novel Diard-Hbv Dna Qpcr Kit With The Artus Hbv Qs-Rgq Kit For Quantification Of Hbv Dna In Clinical Samples, Ülker Çuhaci, Hande Toptan, Bengül Durmaz, Mehmet Köroğlu, Riza Durmaz

Turkish Journal of Medical Sciences

Background/aim: Hepatitis B virus (HBV) leads to widespread chronic infections that may result in long-term complications such as cirrhosis and hepatocellular carcinoma. The use of sensitive molecular methods for HBV DNA quantitation has provided significant contributions for diagnosis and monitoring of disease. The current study aimed to evaluate the diagnostic performances of a novel DiaRD HBV qPCR kit (novel kit) in comparison with the artus HBV QS-RGQ kit (comparator kit).

Materials and methods: A total of 288 plasma samples—105 HBV DNA-positive and 183 HBV DNA-negative—were tested using both kits. The diagnostic and quantitative results of the novel kit were compared …

Sinapic Acid Alleviates Renal Ischemia-Reperfusion Injury By Regulating Oxidative Stress, Apoptosis, And Inflammation, Mustafa Can Güler, Fazi̇le Nur Eki̇nci̇ Akdemi̇r, Ersen Eraslan, Ayhan Tanyeli̇, Derya Güzel Erdoğan, Behzat Tebri̇zi̇

Turkish Journal of Medical Sciences

Background/aim: Acute kidney injury (AKI) is a major clinical issue, frequently resulting from ischemia-reperfusion (I/R) injury. Sinapic acid (SA), a natural phenolic molecule included in numerous plant-based foods, exhibits antiapoptotic, antioxidant, and antiinflammatory properties. This study aimed to investigate the renoprotective effects of SA in an I/R-induced acute kidney injury (AKI) model.

Materials and methods: Sprague–Dawley male rats (n = 32) were randomly assigned to four groups: sham, I/R, SA 20 mg/kg, and SA 40 mg/kg. SA was administered intraperitoneally before reperfusion. Renal tissues were examined using biochemical, histopathological, and immunohistochemical methods, focusing on oxidative stress, cytokine expression, and apoptosis …

Consensus Paper On Candida Auris By Türkiye Ekmud, Thsk Of Ministry Of Health Of The Republic Of Türkiye, Klimud, Tmc, Tard, Tybd And Id-Iri, Canan Ağalar, Hakan Erdem, Yasemi̇n Çağ, Bi̇lgi̇n Arda, Recep Balik, Ali̇ye Baştuğ, Burcu Dalyan-Ci̇lo, Nuretti̇n Erben, Esma Eryilmaz-Eren, Gülşen İskender, Ayşe Kalkanci, Ni̇lgün Karabiçak, Zeli̇ha Koçak-Tufan, Emi̇ne Parlak, Nagehan Di̇dem Sari, Murat Sayin, Seni̇ha Şenbayrak, Recep Teki̇n, Ayşegül Ulu-Kiliç, Tuğhan Utku, Ömrüm Uzun, Göknur Yapar Toros, Sevtap Arikan-Akdağli

Turkish Journal of Medical Sciences

Candida auris is an emerging fungal pathogen that has become a critical global health concern due to its high antifungal resistance and potential to cause nosocomial outbreaks. Since its initial identification in Japan in 2009, C. auris has spread rapidly, posing significant treatment challenges across various healthcare settings worldwide. The biofilm formation ability of C. auris enhances its resilience against disinfectants and antifungal agents, complicating infection control in healthcare environments. This consensus report, developed with the collaboration of several Turkish medical specialty societies, including the Turkish Society of Infectious Diseases and Clinical Microbiology Specialty (EKMUD), the Turkish Society of Anesthesiology …

Incidence Of And Risk Factors For Hyperoxemia Among Potentially Critically Ill Patients Treated In The Wards: A Retrospective Study, Mehmet Nuri̇ Yakar, Doğukan Şenberber, Ozan Balkabak, Nurgazy Shermatov, Kaan Köşker, Seli̇n Elden, Emel İbi̇şoğlu, Begüm Ergan, Volkan Hanci, Necati̇ Gökmen

Turkish Journal of Medical Sciences

Background/aim: The literature shows a link between hyperoxemia and poor outcomes, whereas this association remains unclear in hospital wards. This study aims to determine the incidence of hyperoxemia in hospital wards and its risk factors.

Materials and methods: Patients aged ≥ 18 years who underwent an evaluation by an intensivist between 1 January 2020 and 31 December 2020, while receiving treatment in hospital wards, were included in the study following ethics committee approval. Patients with hypoxemia (partial pressure of oxygen [PaO2] < 60 mmHg), a condition related to Coronavirus disease 2019, a hospital stay < 1 day, or missing data were excluded. Patients were divided into two groups: normoxemia (60 mmHg ≤ PaO2 < 120 mmHg) and hyperoxemia.

Results: The incidence of hyperoxemia was 42.2%. Patients with hyperoxemia had longer hospital stays and higher intensive care unit …

Evaluating Current Practices In Operative Nontechnical Skills Training And Feedback In General Surgery Residency: A Mixed Methods Approach, Madeline Cloonan

Theses & Dissertations

Background: Non-technical skills (NTS) are the interpersonal and cognitive abilities that are critical to accomplishing high-risk tasks. Deficiencies in NTS, including communication, teamwork, leadership, and decision-making, are linked to errors in the operating room. Structured training and feedback in NTS remain inconsistent and have not been integrated into daily training. This dissertation addresses this gap by evaluating current NTS training and feedback practices and developing a rubric to enhance the effectiveness of NTS feedback.

Methods: We conducted five complementary studies to assess current NTS training and feedback. The first was a systematic review aimed at identifying intraoperative NTS training interventions …

Colostrum Extracellular Vesicle Are Neuroprotective In The Mptp Intoxicated Mouse Model Of Parkinson's Disease, Samia Akter

Theses & Dissertations

Parkinson’s Disease (PD) is the second most common neurodegenerative disorder. Dopaminergic neuronal loss in the substantia nigra and the formation of Lewy bodies are the disease pathological hallmarks. We demonstrate that bovine colostrum extracellular vesicles (EVs) induce anti-inflammatory and neuroprotective activities during MPTP (methyl-4-phenyl-1,2,3,6-tetrahydropyridine) intoxication. Treatment these mice with colostrum EVs reduced the extent of activated microglia and neurodegenerative activities. RNA sequencing and transcriptomic analysis revealed a significant decrease in pro- inflammatory responses, as well as reduced recruitment and activation of immunocytes in affected brain tissues. Decreased expression of pro-inflammatory cytokines and chemokines, as well as suppressed canonical inflammasomes, was …

Study Of Peptide Amphiphiles As Antimicrobial Agents, Aramis J. Pereira

Theses & Dissertations

The global antimicrobial resistance (AMR) crisis presents a severe public health threat, with drug-resistant infections now the third leading cause of mortality worldwide. This escalating problem, driven by the rapid proliferation of multidrug-resistant organisms (MDROs) like the "ESKAPE" pathogens, severely limits treatment options and imposes substantial economic burdens. The crisis is further exacerbated by a limited pipeline of new antimicrobial agents, as most recently approved drugs are modifications of existing classes rather than novel compounds. Peptide amphiphiles (PAs) offer a promising alternative due to their membrane-targeting mechanism, which reduces the likelihood of resistance development. These molecules are amphiphilic and positively …

Oncoplastic Nipple-Sparing Mastectomy And Immediate Reconstruction In Non-Ideal Candidates, Aaron Dadzie, Yossef Alsabawi, Sonia Y. Khan, Paul Berry

School of Medicine Publications

Mastectomies have long been used as a surgical treatment for malignant and benign disorders of the breast, both as a therapy and prophylaxis in high-risk patients. A nipple-sparing mastectomy (NSM) allows for the removal of most of the glandular and ductal tissues while preserving the surface architecture of the nipple-areola complex (NAC). This report summarizes the current mastectomy practices and suggests an expansion of the established surgical selection criteria for NSM in the context of immediate implant-based breast reconstruction. We present two cases in which a novel hybrid oncoplastic approach was used and discuss its safety and efficacy when performing …

Informatics At The Frontier Of Cancer Research, Kathleen Noller, Malachi Griffith, Daniel Marcus, Et Al.

2020-Current year OA Pubs

Digitized healthcare data, high-throughput profiling technologies, and data repositories have facilitated the emergence of a new era of cancer research. Each data stream requires specialized analysis methods for interpretation. The data-driven era of cancer research requires the development, enhancement, and sustainment of informatics technology software infrastructure, including fundamental methodology development in artificial intelligence and data science. We review current and emerging informatics technology developments for cancer research and discovery, spanning molecular and cellular characterizations, image analysis, informatics, and therapeutics. Summarizing the diverse methods and applications of informatics throughout cancer research identifies themes and emerging areas for the next generation of …

Skin-To-Skin Contact At Birth For Very Preterm Infants And Symptoms Of Depression And Anxiety In Parents During The First Year – A Secondary Outcome Of A Randomized Clinical Trial, Siri Lilliesköld, Karoline Lode-Kolz, Björn Westrup, Nils Bergman, Kimmo Sorjonen, Ulrika Ådén, Evalotte Mörelius, Siren Rettedal, Wibke Jonas

Research outputs 2022 to 2026

Background: Mental health issues are common in parents to preterm infants. In the neonatal intensive care unit (NICU), skin-to-skin contact (SSC) as an avenue for parent-infant closeness may improve parental mental health. Few studies exist regarding its benefits when initiated immediately postbirth. The aim was to determine the effect of SSC for very preterm infants at birth on parents' mental health, by assessing symptoms of depression and anxiety within the first year. Methods: The Immediate Parent-Infant Skin-to-Skin Study was a randomized clinical trial conducted 2018–2021 at three NICUs in Sweden and Norway. Very preterm infants (28–33 weeks of gestation) were …

Integration Of Spatial Protein Imaging And Transcriptomics In The Human Kidney Tracks The Regenerative Potential Of Proximal Tubules, Mahla Asghari, Sanjay Jain, Et Al.

2020-Current year OA Pubs

The organizational principles of nephronal segments are based on anatomical and physiological attributes that are linked to the homeostatic functions of the kidney. Recent molecular approaches have uncovered layers of deeper signatures and states in tubular cells that arise at various time points on the disease trajectory. Here, we introduce an analytical pipeline of multiplexed spatial protein imaging integrated with RNA expression to characterize proximal tubular subpopulations and neighborhoods in human kidney tissue. We demonstrate that, in reference tissue, a large proportion of S1 proximal tubular epithelial cells expresses thymus antigen 1 (THY1), a mesenchymal stromal and stem cell marker …

Sox2 Regulates Foregut Squamous Epithelial Homeostasis And Is Lost During Barrett’S Esophagus Development, Ramon U Jin, Yuanwei Xu, T Mamie Lih, Yang-Zhe Huang, Toni M Nittolo, Blake E Sells, Olivia M Dres, Jean S Wang, Qing K Li, Hui Zhang, Jason C Mills

Faculty, Staff and Students Publications

Esophageal adenocarcinoma is increasingly prevalent and is thought to arise from Barrett's esophagus (BE), a metaplastic condition in which chronic acid and bile reflux transforms the esophageal squamous epithelium into a gastric-intestinal glandular mucosa. The molecular determinants driving this metaplasia are poorly understood. We developed a human BE organoid biobank that recapitulates BE's molecular heterogeneity. Bulk and single-cell transcriptomics, supported by patient tissue analysis, revealed that BE differentiation reflects a balance between SOX2 (foregut/esophageal) and CDX2 (hindgut/intestinal) transcription factors. Using squamous-specific inducible Sox2-KO (Krt5CreER/+ Sox2Δ/Δ ROSA26tdTomato/+) mice, we observed increased basal proliferation, reduced squamous differentiation, and expanded metaplastic glands at …

Implementation Of Clinical Practice Guidelines To Prevent Cervical Cancer: Mixed Methods Study, Oliver C Ezechi, Folahanmi T Akinsolu, Olunike R Abodunrin, Oluwabukola M Ola, Chisom Obi-Jeff, Ishak K Lawal, George U Eleje, Joseph D Tucker, Juliet I Iwelunmor

2020-Current year OA Pubs

BACKGROUND: Cervical cancer is a common cause of death among women globally, particularly in Africa. Each year, an average of 7093 women in Nigeria die from cervical cancer. Clinical practice guidelines developed by the Society of Obstetrics and Gynecology of Nigeria (SOGON) aim to prevent cervical cancer. However, the extent of their adoption among gynecologists remains unclear.

OBJECTIVE: This study aimed to assess Nigerian gynecologists' awareness, understanding, and incorporation of the SOGON clinical practice guidelines for cervical cancer prevention in their clinical practices.

METHODS: A convergent parallel mixed methods design was used. Quantitative data were collected via a web-based and …

Sox2 Regulates Foregut Squamous Epithelial Homeostasis And Is Lost During Barrett's Esophagus Development, Ramon U. Jin, Yuanwei Xu, T. Mamie Lih, Yang-Zhe Huang, Toni M. Nittolo, Blake E. Sells, Olivia M. Dres, Jean S. Wang, Qing K. Li, Hui Zhang, Jason C. Mills

2020-Current year OA Pubs

Esophageal adenocarcinoma is increasingly prevalent and is thought to arise from Barrett's esophagus (BE), a metaplastic condition in which chronic acid and bile reflux transforms the esophageal squamous epithelium into a gastric-intestinal glandular mucosa. The molecular determinants driving this metaplasia are poorly understood. We developed a human BE organoid biobank that recapitulates BE's molecular heterogeneity. Bulk and single-cell transcriptomics, supported by patient tissue analysis, revealed that BE differentiation reflects a balance between SOX2 (foregut/esophageal) and CDX2 (hindgut/intestinal) transcription factors. Using squamous-specific inducible Sox2-KO (Krt5CreER/+ Sox2Δ/Δ ROSA26tdTomato/+) mice, we observed increased basal proliferation, reduced squamous differentiation, and expanded metaplastic glands at …

A Chronic Acinetobacter Baumannii Pneumonia Model To Study Long-Term Virulence Factors, Antibiotic Treatments, And Polymicrobial Infections, Clay D Jackson-Litteken, Gisela Di Venanzio, Manon Janet-Maitre, Ítalo A Castro, Joseph J Mackel, Leslie D Wilson, David A Rosen, Carolina B López, Mario F Feldman

2020-Current year OA Pubs

Acinetobacter baumannii causes prolonged infections that disproportionately affect immunocompromised populations. Our understanding of A. baumannii respiratory pathogenesis relies on an acute murine infection model with limited clinical relevance that employs an unnaturally high number of bacteria and requires assessment of bacterial load at 24-36 h post-infection. Here, we demonstrate that low intranasal inoculums in tlr4 mutant mice allows for infections lasting at least 3 weeks. Using this "chronic infection model" we determine the adhesin InvL is a virulence factor required during later stages of infection, despite being dispensable in the early phase. We also demonstrate that the chronic model enables …

Highly Potent And Subtype-Selective Sperm-Specific Potassium Channel Slo3 Inhibitors Display High Tissue Exposure In The Murine Female Reproductive Tract, Kayla J Temple, Ping Li, Maximilian D Lyon, Shweta Bhagwat, Leila Asadi, Sophia Li, Ronald Mccarthy, Celia M Santi, Et Al.

2020-Current year OA Pubs

To date, the study of drug exposure and distribution throughout the female reproductive tract has often been overlooked and neglected. Herein, we report the first highly potent and subtype-selective sperm-specific potassium channel 3 (SLO3) inhibitors as a new modality of contraceptives. After extensive

Program Leaders’ Plans, Perceptions, And Anticipated Effects Of Preference Signaling Before Implementation In Ophthalmology, Melissa Goldin, Alvina Liang, Quentin Eichbaum, Edwin Williamson, Janice Law, Reid Longmuir, Jennifer L. Lindsey

Journal of Academic Ophthalmology

Purpose: To assess the plans, perceptions, and anticipated effects of preference signaling on the 2024e2025 match cycle among ophthalmology program directors and associate program directors. Methods: A 16-item questionnaire was distributed to 177 ophthalmology program directors and associate program directors prior to the start of the 2024e2025 application cycle. Results: The questionnaire was completed by 71 ophthalmology program directors and associate directors (40 % response rate). Sixty-two program leaders (89 %) planned to incorporate signaling into the application review process. The most common plan was to give additional consideration throughout the application review process (n ¼ 45 [63 %]) followed …

Patterns Of Ophthalmology-Related Interfacility Transfers To The Emergency Department By Temporal Trends, Laura E. Ramirez, Michael Waxman, Denis R. Pauze, Edward J. Wladis

Journal of Academic Ophthalmology

Background: Interfacility transfer patients are associated with inferior outcomes, higher costs, and emergency department (ED) overcrowding. Previous studies have analyzed the general trends influencing interfacility transfers, but the patterns affecting ophthalmology-related transfer rates remain unclear. The purpose of this study was to identify and quantify the patterns of interfacility ophthalmology-specific transfers to the ED by temporal trends and to determine the type of ophthalmic services required by the transferred population.

Methods: All patients transferred to the ED of a single level 1 trauma center because of ophthalmology-related complaints from 2016 to 2023 were analyzed retrospectively. Transfer and nontransfer …

Analyzing The Role Of Ai In Resident Education: An Evaluation Of Chatgpt On Ophthalmology Trainee Examination Questions By Subtopic, Kimberly Cartagena, Simran Ohri, Carolina Ramos, Yaxel Levin-Carrion, Alexandra Sanchez, Marko Oydanich, Albert S. Khouri

Journal of Academic Ophthalmology

Background: ChatGPT is a large-scale language model trained on various datasets to learn, analyze, and generate human-like answers to user’s questions. To assess its applicability to medical education, more information is required to understand whether its analyses can provide accurate and coherent responses to questions. The aim of this study was to characterize ChatGPT responses to ophthalmology questions according to subtopic to determine where the system might be used reliably in resident education and where its performance remains weak.

Methods: Ophthalmology questions were obtained from a widely utilized study resource, OphthoQuestions. Thirteen sections, each with a differing ophthalmic …

Integrating Artificial Intelligence And Evidence-Based Guidelines Into Nursing Education, Allyson Kornahrens, Kerriann Latten

International Journal of Transformative Teaching and Learning in Higher Education

Artificial Intelligence (AI) and emerging technologies are transforming the healthcare system and patient care delivery. Due to this, there is an essential need for faculty to incorporate AI into the nursing curriculum to educate students about its use and improve preparation for clinical practice. This practice-based article addresses the integration of AI into nursing education for students using AI-driven academic learning activities. These activities, created in alignment with the American Association of Colleges of Nursing (AACN) Essentials, explore clinical decision-making by comparing AI recommendations to evidence-based guidelines. Students are tasked with reflecting on AI’s accuracy and the ethical implications of …

Living With Disability After Spinal Cord Injury: A Grounded Theory Methodology, Diaa K. Abd Ali

Al-Ameed Journal for Medical Research and Health Sciences

Study Design: A Grounded Theory Methodology is employed to investigate the study phenomenon. the entire study started from Jan. 15^th. 2021 to March, 1^st. 2022.

Aim: The study is conducted to explore the concepts that shape the experience of living with disability among patients with spinal cord injury, and to formulating a grounded theory regarding nursing care for patients with spinal cord injuries.

Setting: The study is conducted in Ibn Alkuf Hospital for Spinal Cord Injuries, Baghdad, Iraq.

Methods: A non-probability purposive sampling technique was used to select (12) patients with chronic (more than 5 years) …

A Qualitative Analysis Of The Lived Experience Of Active-Duty Servicewomen Receiving Perinatal Care Within The Military Health System., Caitlin Russell, Emily Balog, Anne Teitelman, Rosemary Polomano

Rowan-Virtua School of Osteopathic Medicine Departmental Research

OBJECTIVES: We explored the lived experiences of active-duty servicewomen (ADSW) accessing and receiving care during the perinatal period (from discovery of pregnancy to 1 year postpartum) within the Military Health System.

STUDY DESIGN: Using qualitative methods, we conducted semi-structured interviews between September 2022 and February 2023 with 23 ADSW participants who were pregnant or within their first year postpartum. Data were analyzed using inductive coding and thematic analysis techniques.

RESULTS: Participants reported bureaucratic hurdles and long wait times for accessing care, too little choice in providers, and inadequate coordination between civilian and military care providers. Those who experienced perinatal complications …