Fluid Resuscitation Choice And Its Effect On Plasma Chloride And Acute Kidney Injury In Severe Acute Pancreatitis: A Randomized Study Of Normal Saline Vs. Balanced Crystalloids (Physiomax), Mandip Singh Bhatia, Ritu Attri, Ashok Kumar Pannu, Atul Saroch, Saurabh C Sharda, Neeraj Singla, Sakshi Mehta

Journal of Community Hospital Internal Medicine Perspectives

Background: Acute pancreatitis (AP) is a potentially fatal gastrointestinal condition, often associated with organ failure and acute kidney injury (AKI). Early fluid resuscitation with Normal saline (NS) may lead to hyperchloremia and AKI, which prompted interest in using balanced crystalloids. However, the optimal choice of crystalloid fluid remains uncertain. This study aimed to compare the effects of NS versus Physiomax on plasma chloride levels and AKI incidence during early resuscitation in patients with predicted severe AP (pSAP).

Methods: A single-center, prospective, randomized study was conducted between November 2022 and December 2023 at PGIMER, Chandigarh, India. 112 patients with pSAP were …

Role Of Addiction Medicine Consultation Service In A Community Hospital: Evaluation Of The Novel Service, Srikrishna Varun Malayala, Wesley Cervantes Perez, Rukshar Thapa, Archie Madan, Kushagar Singla, Pragyat Singh, Pelash Kumar, Akshay Thaper

Journal of Community Hospital Internal Medicine Perspectives

Objectives: Fewer than 2,500 physicians nationwide are certified in addiction medicine. Inpatient addiction hospitalist services have been shown to improve patient outcomes, but their capabilities and impact are underexplored in community hospitals. This study evaluates the role of an addiction medicine hospitalist service in enhancing patient outcomes in two community-based hospitals.

Methods: A retrospective chart review was conducted on patients who received care from addiction medicine service in two hospitals. The data were collected within the first 120 days of the establishment of service. The reason for consultation, substances used, types of management, impact on transition of care, readmissions and …

Educational Development For New Gme Programs At Community Hospitals: Process, Outcomes And Recommendations, Ebun O. Ebunlomo, Christine Ford, Kamilla Guinn, Lauren Irwin

Journal of Community Hospital Internal Medicine Perspectives

Introduction: Changes in the U.S. healthcare system have led to graduate medical education (GME) programs expanding beyond academic medical centers to community hospitals. Direct-care physicians at these hospitals are now responsible for supervising trainees, requiring them to develop new skills in education. This article describes how our educational development office collaborated with community hospital GME program directors to pilot faculty development programming to integrate community hospital physicians into trainee education.

Methods: We met with program directors for two GME community programs, reviewed topics that would be most helpful to clinicians who are unfamiliar with education, and organized workshops …

Inovasi Aplikasi Adhimukti Brata Care Stunting Berbasis Appsheet Untuk Pendataan Status Gizi Anak Di Kabupaten Banggai, Moh. Saputra Tambora, Imelda Hutasoit

Jurnal Biostatistik, Kependudukan, dan Informatika Kesehatan

Stunting merupakan masalah kesehatan serius di Indonesia, termasuk di Kabupaten Banggai dengan prevalensi 29,1% pada tahun 2023. Keterlambatan intervensi sering terjadi akibat keterbatasan data gizi anak yang akurat, terbaru, dan mudah diakses. Penelitian ini bertujuan mendeskripsikan pengembangan Aplikasi Adhimukti Brata Care Stunting berbasis AppSheet sebagai solusi pendataan gizi anak secara real-time. Metode yang digunakan adalah research and development (R&D) dengan model prototyping, meliputi tahap analisis kebutuhan, perancangan, implementasi, uji coba teknis, dan penyempurnaan. Data diperoleh dari hasil uji coba aplikasi, observasi proses input, serta masukan pengguna awal yaitu petugas DP2KBP3A, PKB, dan kader posyandu. Hasil pengembangan menunjukkan aplikasi …

Development And Validation Of An Ai-Based Lung Lobe Auto-Contouring Tool Using Radiation Therapy Planning Free-Breathing Images, Peter Ciaccio, Joseph Lombardo, Andrew Fuquay, Soroush Pahlavian, Rachel Grimm, Jun Kang, Wookjin Choi, Paul Sullivan, Yevgeniy Vinogradskiy

Department of Radiation Oncology Faculty Papers

BACKGROUND: Pulmonary toxicity can occur during radiation therapy of the lungs. Dose metrics evaluated at the lobar level can improve the ability to predict toxicity. Contouring lung lobes is challenging and time consuming. Currently there are limited dosimetry studies evaluating the dose to lung lobes. The purpose of this work was to develop and validate an artificial intelligence (AI) lung lobe auto-contouring algorithm using radiation therapy planning images.

MATERIALS AND METHODS: Fifty lung cancer patients from two institutions were analyzed, and a clinician contoured all five lung lobes [left upper lobe (LUL), left lower lobe (LLL), right upper lobe (RUL), …

Resolution Of Physics And Deep Learning-Based Protein Engineering Filters: A Case Study With A Lipase For Industrial Substrate Hydrolysis, Spencer Gardiner, Peter Dollinger, Filip Kovacic, Jörge Pietruszka, Daniel Ess, Karl-Erich Jaeger, Gunnar F. Schröder, Dennis Della Corte

Faculty Publications

Computational enzyme design remains a powerful yet imperfect tool for optimizing biocatalysts, especially when targeting non-natural substrates. Using design tools we investigated Pseudomonas aeruginosa LipA, a lipase with a flexible lid domain crucial for substrate binding and turnover, aiming to enhance its hydrolysis of the industrially relevant substrate Roche ester. We generated an initial set of single-point mutations based on structural proximity to the active site and evaluated their effects using a computational pipeline integrating molecular dynamics (MD) simulations, density functional theory (DFT) calculations, and ensemble-based energy scoring. While we identified several active variants, attempts to rank them by activity …

Opposing Synovial Cannabinoid Receptor Type 2 And Transient Receptor Potential Vanilloid 1 Expression In Painful Osteoarthritis, Collin A. Toups, Lauren G. Guillot, Kaitlyn Redondo, Sydney Jensen, Jennifer Klein, Luis Marrero

School of Medicine Faculty Publications

Knee osteoarthritis (kOA) poses a major health challenge worldwide, but current non-surgical treatments have limited long-term success and do not address the underlying disease process. This study explores the complex relationship between the endocannabinoid system (ECS) and the endovanilloid system (EVS) in the synovial membrane of patients with kOA undergoing total knee replacement, focusing on how these systems relate to patient-reported pain and histological synovitis. Synovial tissues and fluid from patients grouped into high and low pain categories based on the Knee Injury and Osteoarthritis Outcome Score (KOOS) were examined for cannabinoid receptor type 2 (CB2R), transient receptor potential vanilloid …

Association Between Climate Change Awareness And Depression & Anxiety: Findings From A U.S. Sample, Stanley Nkemjika, Colvette Brown, Henry Onyeaka, Srikanta Banerjee, Jennifer Oliphant

Department of Psychiatry and Human Behavior Faculty Papers

BACKGROUND: Exploring the connection between climate change awareness and overall well-being is crucial, particularly in how it impacts both the environment and mental health. The mental health consequences of climate change and its awareness have not been thoroughly examined, especially in the U.S. In this study, the relationship between awareness of climate change and depression or anxiety among U.S. adults was explored. Similarly, the role of climate change awareness has not been explored in relation to mental health concerns.

METHODS: Based on the HINTS-6 dataset, a nationally representative, cross-sectional survey conducted by the National Cancer Institute, a variety of statistical …

Staff Education To Pediatric Healthcare Providers On How To Prevent Unintentional Childhood Injuries., Peter Cleveland Collins

Walden Dissertations and Doctoral Studies

This staff education quality improvement Doctor of Nursing Practice (DNP) project was focused on teaching pediatric healthcare providers how to provide education during wellness visits to prevent unintentional childhood injury. The practice problem at the clinic was that pediatric providers lacked knowledge about injury prevention. A literature review showed that unintentional childhood injuries are the leading cause of death in this population. The practice-focused question determined was to determine if, after educating providers, they have improved knowledge and intent to educate their patients. I used the analysis, design, development, implementation and evaluation (ADDIE) model to guide this project. The participants …

Effects Of 17Β-Estradiol Treatment On Metabolic Function And Aortic Relaxation In Castrated Male Rats, Rifat A. Islam, Md R. Razan, Ankita Poojari, Mohammad M. Rahman, Hao Wei, Hana S. Alhamadsheh, Melanie Felmlee, Atefeh Rabiee, Mitra Esfandiarei, Roshanak Rahimian

Pacific Faculty Work

Exogenous estrogen use in male-to-female individuals has been linked to increased cardiovascular disease risk, though the mechanisms remain unclear. This study examines the effects of 17β-estradiol (E2) on metabolic and aortic function in castrated (CAS) male Sprague Dawley rats. CAS rats received subcutaneous E2 (CAS + E2) or placebo (CAS + PL) pellets for ~35 days, with intact males serving as controls. Endothelium-dependent vasorelaxation (EDV) in response to acetylcholine and contractile responses to phenylephrine were measured in aorta before and after pharmacological inhibitors. Metabolic parameters and expression of proteins associated with vascular and insulin signaling were also determined in aorta …

A Novel Sialylation Pathway Mediated By Extracellular Vesicles In Aggressive Prostate Cancer, Camila A. Bach, Md Niamat Hossain, Ishan J. Chaudhari, Cecilia E. Verrillo, Nicole M. Naranjo, Isabella Amoroso, Anna Testa, Samuel Sey, W. Kevin Kelly, Susan L. Bellis, Aurelio Lorico, Ada G. Blidner, Gabriel A. Rabinovich, Lucia R. Languino

Department of Pharmacology, Physiology, and Cancer Biology Faculty Papers

Altered cell surface glycosylation is a hallmark of cancer; among aberrant glycan structures, hypersialylated proteins contribute to disease progression. The enzyme ST6 β-galactoside α2,6-sialyltransferase 1 (ST6GAL1) mediates α2,6-linked sialylation of N-glycosylated proteins and is upregulated in many cancers, including prostate cancer (PrCa). We propose that ST6GAL1 may be released by cancer cells in small extracellular vesicles (sEVs) in the PrCa tumor microenvironment to potentially modulate cell surface sialylation in recipient cells. We isolated sEVs from PrCa cells by density gradient separation and characterized them by nanoparticle tracking analysis using ZetaView and immunoblotting analysis. We identified ST6GAL1 in both its membrane-bound …

In-Hospital Exposure And Opioids Prescribed After Total Knee Arthroplasty, Clifton Daigle, Robert Branstetter, Leland Van Deventer, Ravi Rajendra, Claudia Leonardi, Amy Bronstone, Vinod Dasa

School of Medicine Faculty Publications

BACKGROUND: Opioids are frequently used intraoperatively and during postanesthesia care unit care in total knee arthroplasty (TKA) cases and are commonly prescribed after surgery despite known adverse effects. This study examined whether in-hospital opioid exposure is related to postoperative opioid prescribing in opioid-naïve TKA patients. METHODS: This retrospective study included opioid-naïve patients (no opioid prescriptions filled during the three months before TKA) who had unilateral primary TKA between May 1, 2020, and November 30, 2023, performed by an orthopaedic surgeon. All patients were treated using the same multimodal pain protocol. Opioid prescriptions filled by patients during the three months following …

Nevus Sebaceous Of Jadassohn With Secondary Cystic Papillary Hidradenoma, Jordan A. Book, Rosemary Prejean, Jonathan M. Joseph, Nicholas Culotta, Christopher Haas

School of Medicine Faculty Publications

Nevus sebaceous of Jadassohn (NS) is a congenital cutaneous hamartoma that typically presents at birth as a plaque on the face, scalp, or neck. While NS is associated with a risk of neoplastic transformation, the majority of secondary tumors are benign, with the most common being trichoblastomas and syringocystadenomas. In this report, we present a rare case of a 63-year-old male with a right parietal scalp NS with a secondary cystic papillary hidradenoma (HP), which is a benign tumor that almost exclusively occurs in the perineal region. Histopathologic examination was consistent with NS, revealing hyperkeratosis, parakeratosis, increased sebaceous glands, ectopic …

Optimization Of Spinal Cord Perfusion Pressure For Improvement Of Neurological Outcome In Traumatic Spinal Cord Injury: A Systematic Review And Meta-Analysis, Gabrielle E. Hovis, Brandon Sherrod, Nitin Agarwal, Berje H. Shammassian, Anthony M. Digiorgio, Ramesh Grandhi, Bryce Picton

School of Medicine Faculty Publications

The optimal hemodynamic management of traumatic spinal cord injury (tSCI) is not well established. We performed a systematic review and meta-analysis of patients with acute tSCI to assess the role of lumbar cerebrospinal fluid drainage (CSFD) and to identify factors predictive of neurological improvement. Three studies involving 46 patients with acute tSCI, lumbar drain placement with CSFD, and available pre- and post-intervention American Spinal Injury Association (ASIA) Impairment Scale or International Standards for Neurological Classification of Spinal Cord Injury (ISNCSCI) motor scores were identified. One study was analyzed separately (Cohort A) using ASIA grade because post-intervention ISNCSCI motor scores were …

Erratum To “Cardiac Screening Findings And Referral Patterns In Male African-American Basketball Players: Analysis Of The Heartbytes Registry”[The American Journal Of Cardiology 243 (2025) 73-80], Douglas Corsi, Avinash Saraiya, Maggie Doyle, Vacha Shah, Blaise O’Malley, Grace Qiu, Renee Lanstaff, Imran Masood, Brian Osler, Alexander Hajduczok, Drew Johnson, David Shipon

Division of Cardiology Faculty Papers

No abstract provided.

Infusion Of Blood From Young And Old Mice Modulates Amyloid Pathology, Matias Pizarro, Ruben Gomez-Gutierrez, Ariel Caviedes, Catalina Valdes, Ute Woehlbier, Cristian Vargas, Mauricio Hernandez, Claudia Duran-Aniotz, Rodrigo Morales

Faculty, Staff and Student Publications

Alzheimer's disease (AD) is a neurodegenerative disease characterized by the accumulation of misfolded proteins in the brain. Recently, the impact of blood components in the progression of this disease has come to attention. This study investigates the effects of infusing blood from young and old wild-type mice into transgenic mice that model AD brain amyloidosis. Impaired memory and Aβ accumulation were observed in mice infused with blood from old donors. A proteomic analysis in the brain of these mice identified alterations in components related to synaptogenesis and the endocannabinoid system. The α2δ2 protein, associated with neuronal calcium regulation, was validated …

Loss Of Ptdss1 In Tumor Cells Improves Immunogenicity And Response To Anti-Pd-1 Therapy, Jielin Liu, Shelley Herbrich, Sreyashi Basu, Yulong Chen, Ashwat Nagarajan, Swetha Anandhan, Sangeeta Goswami, Liangwen Xiong, Baoxiang Guan, Padmanee Sharma

Faculty, Staff and Student Publications

PTDSS1 (phosphatidylserine synthase 1) encodes an enzyme that facilitates production of phosphatidylserine (PS), which mediates a global immunosuppressive signal. Here, based on in vivo CRISPR screen, we identified PTDSS1 as a target to improve anti-PD-1 therapy. Depletion of Ptdss1 in tumor cells increased expression of interferon-γ (IFN-γ)-regulated genes, including B2m, Cxcl9, Cxcl10, and Stat1, even in the absence of IFN-γ stimulation in vitro. Loss of Ptdss1 in tumor cells also led to increased expression of MHC-I, enhanced cytotoxicity of CD8+ T cells, and increased frequency of an iNOS+ myeloid subset. A gene signature derived from the …

Distinct Transcriptional Regulation Of The Wnt And Tgfβ Signaling Families Associated With Wound Healing And Fibrotic Outcomes To Lens Injury, Catherine Lalman, Kylie R. Stabler, Joshua Disatham, Lisa A. Brennan, Marc Kantorow, Janice L. Walker

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Posterior capsule opacification (PCO) is a fibrotic complication of cataract surgery caused by aberrant repair of residual lens cells. It remains unclear how the lens injury response shifts toward a pathological repair process. Here, we performed a transcriptional analysis of two major pro-fibrotic pathways, the TGF-β superfamily and Wnt signaling pathways to determine how they are differentially regulated during regenerative wound healing versus fibrosis in a lens injury model. For these studies, RNA sequencing was performed on an ex vivo lens explant system that models post-surgical healing within regenerative and fibrotic microenvironments, from 0 to 3 days post-injury. Fibrotic conditions …

Targeting Kinin B1r Attenuates Hypertension Through At1r-Dependent Mechanisms, Drew Theobald, Riley N. Bessetti, Yumei Feng Earley, Eric Lazartigues, Karen Litwa, Srinivas Sriramula

School of Medicine Faculty Publications

BACKGROUND: Neurogenic hypertension is chronically high blood pressure that is initiated and maintained through excessive sympathetic nervous system activity and has been associated with increased B1R (kinin B1 receptor) activation. We previously reported a central role for B1R in mediating inflammatory pathways in the development of deoxycorticosterone acetate salt hypertension. Additionally, we identified a causal relationship between B1R expression after Ang II (angiotensin II) stimulation, and that B1R can mediate the bidirectional interaction between neuroinflammation and oxidative stress. However, whether there are any interactions between AT1R (Ang II-type I receptor) and B1R, and if B1R can mediate the effects of …

A Qualitative Exploration Of Child, Caregiver, And Clinician Perspectives On Mental Health In Children With Osteogenesis Imperfecta, Justin H Qian, Andrew D Wiese, Clarissa Gonzalez, Whitney S Shepherd, Hannah Cho, Gianna M Colombo, Julia M Morales, Selena Guo, Kristin M Kostick-Quenet, Dianne Nguyen, Sophie C Schneider, Kara Ayers, Members Of The Bbdc, Marie-Eve Robinson, Chaya N Murali, Brendan Lee, V Reid Sutton, Eric A Storch

Center for Medical Ethics and Health Policy Staff Publications

Osteogenesis imperfecta (OI) is a heritable connective disorder with clinical manifestations including bone fragility and short stature. Previous research identified psychosocial themes related to mental health among children with OI and their caregivers, such as independence, social isolation, depression, and anxiety. Several studies have also examined clinicians of individuals with OI for their perspectives on mental health among their patients. However, no known studies have compared psychosocial themes among all three participant groups concurrently. This qualitative study examined mood and anxiety, along with risk and protective factors, from perspectives of youths, parents, and clinicians. Semi-structured interviews were conducted, which were …

Identification And Characterization Of A Metal Binding-Independent Rift Valley Fever Virus Endonuclease Inhibitor, Cara D Kirby, Gai Liu, Farheen Fatma, Maris R Pedlow, Narendran G-Dayanandan, Nitin Sharma, Zachary D Frey, Rachael E Rush, Steven C Cardinale, Andrzej M Krezel, Amy L Hartman, Terry L Bowlin, Daisy W Leung, Gaya K Amarasinghe

2020-Current year OA Pubs

The viral cap-snatching mechanism, facilitated by the endonuclease (EndoN) domain of viral polymerases, is critical for viral gene transcription and translation and is therefore an attractive target for antiviral development. The successful development of EndoN inhibitor XOFLUZA (Baloxavir marboxil) has opened the possibility that the EndoN domain of negative-sense RNA viruses (NSVs) can be targeted in a similar fashion. Rift Valley Fever Virus (RVFV) belongs to the

Rural Providers' Attitudes Toward Integrating Harm Reduction Strategies And Prep Prescribing Into Rural Primary Care Settings In The Us. Southeast And Midwest, Phillip L Marotta, Miryam Biaid, Virginia Mckay, Hilary Reno, Lindsey Filiatreau, Kaileigh Backes, Patricia Cavazos-Rehg, Et Al.

2020-Current year OA Pubs

BACKGROUND: People with opioid use disorders (OUD) living in the South and Midwest are under-prescribed pre-exposure prophylaxis (PrEP) despite an increasing number of providers writing PrEP prescriptions in other regions of the United States. Greater research is needed into attitudes toward integrating harm reduction strategies into primary care and PrEP prescribing among prescribers working in rural primary care settings. The objective of this paper was to examine relationships between providers' attitudes toward buprenorphine and methadone, comprehensive harm reduction (e.g., fentanyl test strips) and self-reported PrEP prescribing in the past year.

METHODS: Relationships were examined between attitudes toward buprenorphine and harm …

Information & Schedule Flyer, Macon & Joan Brock Virginia Health Sciences At Old Dominion University

Cardiovascular Research Symposium

Information and schedule for Cardiovascular Research Symposium: Bridging Gaps and Advancing Care.

Application Of Improved Super-Elastic Ti-Ni Alloy Wire For The Treatment Of Adult Skeletal Class Ii With Severe Deep Bite, Pin-Yu Chen, Yuan-Hou Chen, Jian-Hong Yu

Taiwanese Journal of Orthodontics

An adult female (26 years old) with a chief complaint of poor dental alignment, deep bite, and maxillary protrusion came for orthodontic evaluation. Clinical examination indicated Class II canine relationship combined with large overbite and overjet and accentuated Curve of Spee. Radiographic examination showed skeletal Class II and lower right first molar missing. Improved Super-elastic Ti-Ni alloy wire (ISW, developed by Institute of Science Tokyo) curve was added over the lower arch to flatten Curve of Spee, and extraction of bilateral upper first premolars with intramaxillary elastics to perform anterior retraction was considered. At the end of treatment, we achieved …

Goal-Oriented Aesthetic Treatment (Goat): A Systematic Framework For Three-Dimensional Facial Aesthetic Assessment — Part 2: Sagittal Dimension, Heng-Ming Chang, Yu-Chun Su, Min-Hsun Hsu, Yu-Ting Lin, Chih-Wei Wang

Taiwanese Journal of Orthodontics

Facial aesthetics is a multidimensional concept that requires an integrative assessment of the sagittal, vertical, and transverse planes to achieve balance and harmony. Following the evaluation of the vertical dimension in Part I, this review focuses on the sagittal plane, which plays a pivotal role in facial profile balance and anteroposterior skeletal relationships. The Goal-Oriented Aesthetic Treatment (GOAT) framework provides a structured methodology for diagnosing and addressing sagittal discrepancies, incorporating clinical reference lines, chin morphology, incisor inclination, and anchorage considerations. A comprehensive assessment of the sagittal dimension involves the use of key diagnostic tools such as the Barcelona Line (BL), …

Goal-Oriented Aesthetic Treatment (Goat): A Systematic Framework For Three-Dimensional Facial Aesthetic Assessment — Part 1: Vertical Dimension, Heng-Ming Chang, Yao Chen, Kwok-Hing Ho, Kai-Long Wang, Chih-Wei Wang

Taiwanese Journal of Orthodontics

Facial aesthetics is a multidimensional concept that requires an integrative assessment of the sagittal, vertical, and transverse planes to achieve balance and harmony. Among these, the vertical dimension plays a crucial role in determining facial proportions, occlusal function, and overall aesthetic perception. This review introduces the Goal-Oriented Aesthetic Treatment (GOAT) framework as a systematic approach to evaluating the vertical aspects of facial aesthetics, providing a structured methodology for clinical assessment and treatment planning. A comprehensive evaluation of the vertical dimension encompasses several key parameters, including facial pattern classification, vertical proportions, lip competency, and overbite analysis. Traditional cephalometric indices, such as …

Predicting Stability And Relapse In Class Iii Patients: The Role Of The Mandibular Plane Angle In Bimaxillary Surgery, Jason Jyun-Cheng Kuo, Min-Chi Chen, Yu-Chih Wang, Ellen Wen-Ching Ko

Taiwanese Journal of Orthodontics

Purpose: Skeletal stability after orthognathic surgery remains challenging in Class III malocclusion. This study examined how preoperative mandibular plane angle (FMA) and its surgical changes affect postoperative outcomes.

Patients and Methods: Sixty adult Taiwanese patients with skeletal Class III malocclusion treated by bimaxillary surgery without genioplasty were retrospectively analyzed. Cone-beam computed tomography (CBCT) at preoperative (T0), immediate postoperative (T1), and orthodontic debonding, ≥ 1-year postoperative (T2) stages was used to measure sagittal (Pog-CP), vertical (Me-FH), and transverse (Go–Go) changes. Pearson correlation and multiple regression analyses were performed.

Results: Smaller preoperative FMA and larger increased intraoperative FMA increases were significantly associated …

Volumetric Analysis And Anatomical Variations Of The Maxillary Sinus: A Cone-Beam Computed Tomography Study, Prafen Pokhrel, Rabindra Man Shrestha, Ujjawal Pyakurel, Roshan Poudel

Taiwanese Journal of Orthodontics

Objectives: The purpose of the study was to determine the volume and to assess the anatomical variations of maxillary sinus using cone-beam computed tomography (CBCT).

Materials and Methods: The study was conducted using 64 CBCT scans of the subjects belonging to the age group 18-50 years. Using Care Stream 3D imaging software, the scans were exported and read in an orthogonal slicing view. The width and length of the sinus were measured in axial section, whereas the height was measured in coronal section. Volume and area of sinus were calculated using 3D Slicer software. The assessment of septa was done …

Transparent Eeg Analysis: Leveraging Autoencoders, Bi-Lstms, And Shap For Improved Neurodegenerative Diseases Detection, Badr Mouazen, Ahmed Bendaouia, Omaima Bellakhdar, Khaoula Laghdaf, Aya Ennair, El Hassan Abdelwahed, Giovanni De Marco

Manufacturing & Industrial Engineering Faculty Publications

Highlights

• Novel hybrid architecture: Combined autoencoders with bidirectional LSTM networks for enhanced EEG signal classification, achieving 98% accuracy in distinguishing AD, FTD, and healthy controls.

• Explainable AI integration: Implemented SHAP (SHapley Additive exPlanations) framework to enhance model transparency and identify entropy as the most influential feature for neurodegenerative disease detection.

• Optimal temporal segmentation: Demonstrated that 5-s EEG windows with 50% overlap provide the best balance between classification accuracy and computational efficiency.

• Comprehensive feature extraction: Utilized Power Spectral Density (PSD) analysis across standard frequency bands (Delta, Theta, Alpha, Beta, Gamma) following autoencoder-based dimensionality reduction.

• Superior performance validation: Outperformed traditional machine learning …

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Modeling Musculoskeletal Combat Casualty Care: Nato Trauma System Performance In Large Scale Combat Operations, Mark P. Cote, Kaitlyn E. Holly, Roman J. Schoenfeld, Matthew R. Bryan, Malina O. Hatton, Mitchel B. Harris, Tracey P. Koehlmoos, Andrew J. Schoenfeld

Department of Orthopaedic Surgery Faculty Papers

BACKGROUND: It is unclear whether the current North Atlantic Treaty Organization (NATO) trauma system will be effective in the setting of Large-Scale Combat Operations (LSCO). We sought to model the efficacy of the NATO trauma system in the setting of LSCO. We also intended to model novel scenarios that could better adapt the current system to LSCO.

METHODS: We developed a discrete-event simulation model for patients with combat musculoskeletal injuries treated within the standard NATO system. The primary outcome of the model was survival. The model's health states were characterized as stable, hypovolemia, sepsis, shock, or death. The model simulated …