Medicine and Health Sciences Commons^™

Addressing Housing As A Health-Related Social Need: Insights And Impacts From Health Share’S Housing Benefit Pilot Program, Monique Gill, Benjamin Gronowski, Megan Holtorf

Articles, Abstracts, and Reports

No abstract provided.

Addressing Barriers To Care For African American Men Facing Prostate Cancer: A Scoping Review Of Navigation Programs, Ashley Nicole Smith, Brittany A. Campbell, Ghilamichael Andemeskel, Peggy Tahir, Joseph Egbunikeokye, Tisha M. Felder Phd, Msw, Barbara Cicerelli, Nynikka R. Palmer

Publications

PURPOSE

African American/Black men are disproportionately impacted by prostate cancer (PCa). Patient navigation is an evidence-based approach to address barriers to care, improve access to care and health outcomes, and reduce disparities. This scoping review provides an in-depth examination of navigation programs in PCa care across the cancer continuum, with a focus on African American/Black men in the United States.

METHODS

We conducted a comprehensive literature search through September 1st, 2023, in PubMed, Embase, Web of Science, and CINAHL Complete, using keywords and index terms within three main themes: PCa, patient navigation, and African American/Black men. We included studies that …

Molecular Determinants Of Neoadjuvant Chemotherapy Resistance In Breast Cancer: An Analysis Of Gene Expression And Tumor Microenvironment, Hedda Michelle Guevara-Nieto, Carlos A. Orozco-Castaño, Rafael Parra-Medina, Jenny Nathaly Poveda-Garavito, Jone Garai, Jovanny Zabaleta, Liliana López-Kleine, Alba Lucia Combita

School of Graduate Studies Faculty Publications

Neoadjuvant chemotherapy (NAC) is a critical component of breast cancer treatment, but the molecular mechanisms underlying resistance remain poorly understood. This study aimed to identify transcriptomic changes associated with NAC resistance across four breast cancer subtypes: Luminal A, Luminal B/HER2-positive, Luminal B/HER2-negative, and Triple-Negative Breast Cancer (TNBC). RNA-seq analysis was performed on paired pre- and post-NAC breast cancer samples from 32 nonresponders. Differentially expressed genes (DEGs) were identified, and functional enrichment analyses were conducted. Protein-protein interaction (PPI) networks were constructed to identify hub genes. Tumor microenvironment (TME) infiltration was estimated using deconvolution algorithms. The results revealed distinct gene expression profiles …

Impact Of Systemic Statins On Periodontal Health: A Retrospective Study In A Lebanese Population, Elsa Boustany, Georgio Saad, Wassim Al Manhal

International Arab Journal of Dentistry

Introduction: Statins, primarily used for cholesterol management, have shown potential in improving periodontal health due to their anti-inflammatory and bone-regenerative properties.

Methods: A retrospective study was conducted on 30 patients under statin medication. A control group of 30 non-statin users was selected using propensity score matching (PSM) to minimize bias. Data on pocket depth, attachment loss, and radiographic bone loss were collected at two time points: T0 and T1. Statistical analysis was performed using RStudio, with a significance threshold set at p < 0.05.

Results: The study revealed significant decrease in pocket depth (p = 0.0027), attachment loss (p …

Evaluation Of The Remineralizing Agents After Orthodontic Bracket Debonding: A Sem-Edx Investigation, Bassant Ashraf Badr, Medhat Elzainy, Noha Ibrahim, Hend El Messiry

International Arab Journal of Dentistry

Objectives: To compare the remineralizing efficacy of (Fluoride (Fl) Varnish, Nanohydroxyapatite (n-HAp) serum and NovaMin-containing toothpaste) on premolars subjected to orthodontic debonding and a pH-cycling model.

Methods: 60 human premolars were divided into six groups (n=10). Group IA, sound enamel, IB, orthodontically treated premolars, IC, orthodontically treated premolars subjected to demineralization cycles. Three experimental groups included orthodontically treated premolars subjected to demineralization cycles and treated with Fl varnish (IIA), n-HAp serum (IIB), and NovaMin toothpaste (IIC). Surface topography and mineral content were evaluated using SEM-EDX analysis, and data were statistically analyzed using ANOVA test and Tukey’s post-hoc test. …

Management Of A Periapical Cyst In An 8-Year-Old Patient With Challenging Etiology: A Case Report With Three-Year Follow-Up, Nancy Nochahrly, Claire El Hachem, Josephine El Balaa, Elie Khoury, Christelle Abdel Nour, Marlene Khoury

International Arab Journal of Dentistry

The success of pulp therapy in primary teeth depends on accurate diagnosis and effective treatment. Periapical inflammation due to bacterial infection or pulpal necrosis can result in granulation tissue and may activate epithelial rests of Malassez, leading to a periapical cyst. In large cysts, especially in children, marsupialization is preferred to preserve developing teeth and minimize damage to surrounding structures. This case report describes an 8-year-old presenting with spontaneous pain in the lower right jaw. Radiographic examination revealed a round welldefined radiolucency over 1 cm around tooth #84 with root canal treatment and #85 with pulpotomy, with dental bud displacement. …

A Social Media Campaign And Web-Based Survey About Prostate Cancer Genetics: Mixed Methods Study, Amy Leader, Stacy Loeb, Preethi Selvan, Ashley Hunter, Rebecca Hartman, Scott Keith, Veda Giri

Department of Medical Oncology Faculty Papers

BACKGROUND: Germline genetic variants are important for prostate cancer (PCa) management and hereditary cancer risk assessment, but testing is underused. Furthermore, patients are often unaware of the genetic connections to PCa. Social media is increasingly serving as a source of awareness for health information and a method to gather data from a large population.

OBJECTIVE: There were three objectives: to (1) create and test social media messages related to PCa genetics and genetic testing, (2) determine which social media message was most engaging, and (3) assess knowledge of and attitudes toward PCa genetic testing through an online survey using the …

Generalizability Of Neuromuscular Coordination In The Human Upper Extremity After Stroke And Its Implications In Neurorehabilitation, Manuel Portilla-Jiménez, Yoon No Gregory Hong, Komal K Kukkar, Hyung-Soon Park, Sheng Li, Jinsook Roh

Faculty, Staff and Student Publications

Background: Previous studies have shown that stroke often impairs neuromuscular coordination (i.e., muscle synergies) across various biomechanical conditions. In our previous study, we investigated the generalizability of muscle synergies between isometric and free dynamic reaching in healthy individuals. However, the extent to which muscle synergy characteristics after stroke are generalized across these conditions remains unclear.

Methods: Electromyographic signals from eight upper extremity muscles were recorded from 14 chronic stroke survivors with mild-to-severe motor impairment and eight age-range matched controls while performing isometric force generation and point-to-point dynamic reaching tasks. Non-negative matrix factorization was applied to identify muscle synergy characteristics underlying …

Landscape And Clinicopathologic Features Of Ras Pathway Mutations In Chronic Myelomonocytic Leukemia, Guillermo Montalban-Bravo, Sanam Loghavi, Ziyi Li, Kelly Chien, Rashmi Kanagal-Shamanna, Alex Bataller, Anuya Natu, Mark Gurney, Alexandre Bazinet, Danielle Hammond, Koji Sasaki, Gautam Borthakur, Mahesh Swaminathan, Courtney Dinardo, Tapan Kadia, Farhad Ravandi, Naval Daver, Nicholas Short, Naveen Pemmaraju, Ghayas Issa, Terra L Lasho, Christy M Finke, Aref Al-Kali, Clifford Csizmar, Hassan Alkhateeb, Naseema Gangat, Abhishek A Mangaonkar, Carlos Bueso-Ramos, Ayalew Tefferi, Hagop Kantarjian, Guillermo Garcia-Manero, Mrinal M Patnaik

Faculty, Staff and Student Publications

RAS pathway (RASp) mutations induce proliferative features, and promote transformation in chronic myelomonocytic leukemia (CMML). However, the unique clonal landscape and hierarchy of distinct RASp mutations remain unexplored. To characterize the landscape, architecture, and implications of unique RASp mutations in CMML, we evaluated a cohort of 814 patients with CMML. We identified 461 RASp mutations among 342 patients (42%). N/KRAS and CBL mutations were the most common, frequently involved the P-loop or RING domains, respectively, and frequently appeared as dominant events (63% and 65%, respectively). BRAF, NF1, and PTPN11 mutations spanned throughout the gene structure, and frequently appeared as subclonal …

Optimizing Genetic Ancestry Adjustment In Dna Methylation Studies: A Comparative Analysis Of Approaches, Kira D Höffler, Seyma Katrinli, Matthew W Halvorsen, Anne-Kristin Stavrum, Kevin S O'Connell, Alexey Shadrin, Srdjan Djurovic, Ole A Andreassen, James J Crowley, Jan Haavik, Kristen Hagen, Gerd Kvale, Kerry Ressler, Bjarne Hansen, Jair C Soares, Gabriel R Fries, Alicia K Smith, Stéphanie Le Hellard

Faculty, Staff and Student Publications

Background: Genetic ancestry is an important factor to account for in DNA methylation studies because genetic variation influences DNA methylation patterns. One approach uses principal components (PCs) calculated from CpG sites that overlap with common SNPs to adjust for ancestry when genotyping data is not available. However, this method does not remove technical and biological variations, such as sex and age, prior to calculating the PCs. The first PC is therefore often associated with factors other than ancestry.

Methods: We developed and adapted the adapted EpiAnceR+ approach, which includes (1) residualizing the CpG data overlapping with common SNPs for control …

Yx0798 Is A Highly Potent, Selective, And Orally Effective Cdk9 Inhibitor For Treating Aggressive Lymphoma, Vivian Jiang, Yu Xue, Hong Kim, Qingsong Cai, Tianci Zhang, Lei Nie, Joseph Mcintosh, Yang Liu, Haiying Chen, Jia Zhou, Michael Wang

Faculty, Staff and Student Publications

Nongenetic transcription evolution has been increasingly explored and recognized to drive tumor cell progression and therapeutic resistance. As the regulation hub of transcription machinery, cyclin-dependent kinase 9 (CDK9) is the gatekeeper of RNA polymerase II transcription, and CDK9 dysfunction results in transcriptomic reprogramming and tumor cell progression. We recently reported that the heat shock protein 90 (HSP90)-MYC-CDK9 network drives therapeutic resistance in mantle cell lymphoma (MCL) through transcriptomic reprogramming. We also showed that targeting CDK9 by AZD4573 and enitociclib is a safe and effective treatment in preclinical Mantle Cell Lymphoma (MCL) models, supporting CDK9 as a valid therapeutic target for …

Current Insights On Predicting Vestibular Diseases Using Machine Learning, Emre Söylemez, Muhammed Mustafa Şeker

Turkish Journal of Medical Sciences

The vestibular system is one of the three main systems responsible for maintaining balance and posture. Accurate vestibular inputs enable the perception of the head’s position and movement in space, and ensure coordination between head movements, eye movements, balance, and posture. Any dysfunction in the peripheral vestibular end organs, the vestibular nerve, or the central vestibular system may lead to vertigo, dizziness, and gait disturbances in individuals. Some syndromes that cause vertigo symptoms can be life threatening. Although peripheral vestibular pathologies are generally benign, they can reduce patients’ quality of life, cause falls, and hinder independence. Therefore, the diagnosis and …

Unveiling The Potential Of Marine Peptides In Leukemia: Mechanistic Insights And Future Horizon In Peptide Research, Salman Ahmed, Waqas Alam, Khalaf Alsharif, Michael Aschner, Esra Küpeli̇ Akkol, Mamdouh Allahyani, Hayaa Alhuthali, Luci̇ano Saso, Esra Gi̇zem Türkcanoğlu, Haroon Khan

Turkish Journal of Medical Sciences

Leukemia is a malignant disorder that affects the bone marrow and blood. It is frequently diagnosed in adults, with a higher incidence in males than females. Globally, it ranks as the 15th most widespread cancer and is the 11th leading cause of cancer-related fatalities. The intensity and severity of treatment have increased, leading to a rise in relapse rates, toxicity, and adverse health effects. Therefore, there is a critical need for new treatments. The antileukemic properties of natural compounds have been extensively studied. Aquatic organisms are a rich source of potential medicinal compounds. Anticancer peptides offer an ideal treatment approach …

A Randomized Controlled Prospective Study Comparing Surgical Outcomes Of Median Umbilical Ligament Lift-Up And Veress Needle Entry Techniques In Gynecologic Laparoscopic Surgery, Gazi̇ Güner, Ayşe Bacaksiz, Can Berk Karabudak, Fi̇gen Efe Çami̇li, Çi̇sem Ertok, Si̇nem Özşahi̇n Kiliç, Zeli̇ha Zeynep Satilmişoğlu, Can Tercan, Nazli Ayli̇n Vural

Turkish Journal of Medical Sciences

Background/aim: Laparoscopic surgery has become the preferred minimally invasive technique for both diagnostic and therapeutic procedures in gynecology. Although it is associated with lower overall complication rates compared to open surgery, most serious complications occur during the initial step of abdominal entry. Therefore, developing faster and safer entry methods is critical to improving surgical outcomes. This study aimed to compare the surgical results of the Median Umbilical Ligament Lift-Up (MULU) technique routinely used in our clinic with the commonly preferred Veress needle (VN) entry technique.

Materials and methods: This randomized, controlled, prospective study included 124 patients: 64 underwent abdominal entry …

Clinical Characteristics And Outcomes In Epstein-Barr Virus Positive Diffuse Large B-Cell Lymphoma: A Retrospective Multicenter Study, Ebru Kiliç Güneş, Hacer Berna Afacan Öztürk, Esra Ki̇ri̇kti̇r, Asena Di̇kyar, Bi̇lge Uğur, Ahmet Kürşad Güneş, Meltem Ayli

Turkish Journal of Medical Sciences

Background/aimEpstein-Barr virus-positive (EBV+) diffuse large B-cell lymphoma, not otherwise specified (DLBCL-NOS), represents a rare and aggressive subtype of B-cell lymphoma, officially classified as a distinct entity in the revised 4th edition of the World Health Organization (WHO) 2016 classification. This retrospective study aims to evaluate the prevalence, clinical characteristics, histopathological characteristics, and survival results of patients diagnosed with EBV+ DLBCL-NOS.Materials and methodsOur retrospective study included 92 newly diagnosed DLBCL patients treated at two centers between 2016 and 2024. EBV status was determined using in situ hybridization for EBER, with positivity defined as; ≥50% nuclear staining in tumor cells. ResultsAmong 92 …

Comparison Of Canada-United Kingdom-Australia (Canuka) Scores Of Patients With Gastrointestinal Bleeding Presenting To The Emergency Department With Other Gastrointestinal Bleeding Scores, Fatma Hancer Celi̇k, Necmi Baykan, Fatma Unlu, Mustafa Alpaslan, Ayse Sule Akan, Omer Salt, Ibrahim Toker, Nuh Mehmet Buyukberber

Turkish Journal of Medical Sciences

Background/aim: Acute gastrointestinal (GI) tract bleeding is a common and potentially life-threatening condition among patients presenting to emergency departments. In this study, we calculated AIMS65, Rockall, Glasgow-Blatchford Score (GBS), and Canada-United Kingdom-Australia (CANUKA) scores in patients with GI bleeding admitted to the emergency department and compared the sensitivity of these scoring systems in predicting the rates of admission to intensive care units and mortality. It is aimed to contribute to clinical practice and help determine an effective risk assessment tool in the management of patients with GI bleeding.

Materials and methods: The study was conducted with patients who were diagnosed …

A Comparative Study Of Diagnostic Performance In Shoulder Pain: Clinical Tests Versus Ultrasonography And Magnetic Resonance Imaging, Yasemi̇n Tombak, Özgür Zeli̇ha Karaahmet, Ayşegül Tombak, Ömer Ata, Eda Gürçay

Turkish Journal of Medical Sciences

Background/aim: Shoulder pain is common and often evaluated with physical examination tests, yet their diagnostic accuracy remains controversial. The aim of this cross-sectional study was to determine the sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) rates of clinical test results in patients with shoulder pain, based on ultrasonography (US) and magnetic resonance imaging (MRI) findings as reference diagnostic methods.

Materials and methods: The study included 78 patients who had complaints of shoulder pain. All patients underwent physical examinations and specific clinical tests (such as Neer and Jobe tests) to reveal shoulder pathologies, and US and MRI …

Do The Expressions Of Hla-G And Killer Cell Immunoglobulin-Like Receptors Change In Colorectal Cancer?, Ezgi̇ Di̇nçer, Fatma Kaya Dağistanli, Kivanç Derya Peker, Damlanur Sakiz, Fi̇gen Abatay Sel, Demet Kivanç, Hayri̇ye Şentürk Çi̇ftçi̇, Çi̇ğdem Keki̇k Çinar, Şule Karataş, Fatma Savran Oğuz

Turkish Journal of Medical Sciences

Background/aim: The immune system functions as a well-coordinated defense mechanism, protecting the host from both external pathogens and internal threats. Cancer cells often display surface antigens that the immune system can recognize as foreign, potentially triggering an immune response. However, many cancer cells evade detection by downregulating or completely losing these surface antigens. The immune system relies on the expression of surface antigens and human leukocyte antigens (HLA) to identify and target tumor cells. One key method by which tumor cells evade natural killer (NK) cells involves alterations in HLA antigens. Colorectal cancer (CRC) is known to cause various changes …

Characteristics And Complications Of Uveitis In Patients Referred To Rheumatology: A Single-Center Study, Handan Yarkan Tuğsal, Serdar Sezer, Gözde Orman, Gülten Sungur

Turkish Journal of Medical Sciences

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Background/aim: To evaluate the clinical, demographic, and complication data of patients with new-onset uveitis at the ophthalmology and rheumatology departments of a single center.

Materials and methods: This retrospective study included patients newly diagnosed with uveitis who were referred to the rheumatology department for etiological evaluation between August 2021 and August 2024. Patients with a history of rheumatologic diseases associated with uveitis were not included in the study.

Results: A total of 91 patients (female: n = 59, 65%) who met the inclusion criteria were enrolled in the study. The mean age at uveitis diagnosis was 45.7 ± 14.8 …

Hesperidin Efficacy Of Epidural Fibrosis In A Post Laminectomy Rat Model: An Experimental Study, Emrah Keski̇n, Mehmet Seli̇m Gel

Turkish Journal of Medical Sciences

Background/aim: Epidural fibrosis (EF) plays a significant role in the development of failed back surgery syndrome (FBSS). This study evaluates the antifibrotic effect of hesperidin, a citrus-derived bioflavonoid, within a rat laminectomy model.

Materials and methods: Thirty-two female Wistar albino rats were randomized into four groups (n = 8 each). Group 1 received laminectomy alone (control); Group 2 received a gelatin sponge; Groups 3 and 4 intraperitoneally received 50 mg/kg and 100 mg/kg of hesperidin, respectively, for 7 days post-laminectomy. After 6 weeks, epidural tissues were assessed histopathologically, and hydroxyproline levels were measured.

Results: Group 4 showed significantly lower EF …

Assessment Of Alterations In Regional Homogeneity And Amplitude Of Low-Frequency Fluctuations In Children With Dyslexia ​, Esra Demi̇rci̇, Şeri̇fe Gengeç Benli̇, Semra İçer, Zeynep Ak, Ebru Aker, Zehra Fi̇li̇z Karaman

Turkish Journal of Medical Sciences

Background/aim: Exploratory methods in neuroimaging are gaining increasing attention for revealing functional connectivity structures across the entire brain. This study aims to contribute to the understanding of the functional mechanisms underlying dyslexia, along with the effects of specialized education for dyslexia treatment, by utilizing measures such as regional homogeneity (ReHo), amplitude of low-frequency fluctuations (ALFF), and fractional ALFF (fALFF).

Materials and methods: Resting-state functional magnetic resonance imaging data were collected from three groups of Turkish-speaking children aged 7–12: diagnosed with dyslexia for the first time (Dys, n = 19), children with dyslexia who received specialized education (EDys, n = 20), …

Effects Of Olfaction On Sexual Function, Anxiety, Depression, And Quality Of Life In Men And Women With Smell Disorder: A Cross-Sectional Controlled Study ​, Esi̇n Özlem Atmiş, Eser Sağaltici, Eren Yilmaz, Hasan Gökçay, Aytuğ Altundağ

Turkish Journal of Medical Sciences

Background/aim: Olfaction is necessary for healthy sexual intercourse. Better smell has been associated with a more positive sexual experience.

Materials and methods: In this cross-sectional study, 40 patients diagnosed with a smell disorder and 60 healthy volunteers were included. The participants were divided into 2 groups according to sex. The female group had 19 patients and 25 female controls. The male group had 21 patients and 35 male controls. Sniffin’ Sticks tests, the World Health Organization quality of life assessment (WHOQOL), and hospital anxiety and depression scale (HADS) were applied to all participants. In addition, the international index of erectile …

Ai Performance In Emergency Medicine Fellowship Examination: Comparative Analysis Of Chatgpt-4o, Gemini 2.0, Claude 3.5, And Deepseek R1 Models, İshak Şan, Medi̇ne Akkan Öz, Mehmet Yortanli, Murat Genç, Bensu Bulut, Ayşenur Gür, Rami̇z Yazici, Hüseyi̇n Mutlu, Mustafa Önder Gönen

Turkish Journal of Medical Sciences

Background/aim: This study evaluated the accuracy rates and response consistency of four different large language models (ChatGPT- 4o, Gemini 2.0, Claude 3.5, and DeepSeek R1) in answering questions from the Emergency Medicine Fellowship Examination (YDUS), which was administered for the first time in Türkiye.

Materials and methods: In this observational study, 60 multiple-choice questions from the Emergency Medicine YDUS administered on 15 December 2024, were classified as knowledge-based (n = 26), visual content (n = 2), and case-based (n = 32). Each question was presented three times to the four large language models. The models’ accuracy rates were evaluated according …

The Effect Of Beverages And Cleansers On The Color Stability And Surface Roughness Of Conventional And Digital Denture Base Resins ​, Zeynep Şahi̇n, Nazi̇re Esra Özer, Mehmet Ali̇ Kiliçarslan

Turkish Journal of Medical Sciences

Background/aim: Research on the optical and surface properties of 3D-printed denture base materials is limited. This study investigated the effects of different beverages and denture cleansers on the color stability and surface roughness of conventional and digital denture bases.

Materials and methods: A total of 240 specimens were prepared using two digital (CAD/CAM milling and 3D printing) and two conventional (cold- and heat-polymerized) materials. The specimens were immersed in tea, coffee, and artificial saliva for 12 days. After immersion, specimens were cleaned with either sodium hypochlorite or a Corega effervescent tablet. Color changes and surface roughness were measured with a …

Efficacy And Safety Of Low-Power Holmium Laser Enucleation Of The Prostate: Experience Gained From More Than 700 Cases ​, Bahadir Topuz, Can Si̇ci̇mli̇, Ahmet Hali̇s, Engi̇n Kaya, Sercan Yilmaz, Murat Zor, Serdar Yalçin, Selahatti̇n Bedi̇r

Turkish Journal of Medical Sciences

Background/aim: The aim of this study was to investigate the functional outcomes, safety, and effectiveness of low-power (LP) holmium laser enucleation of the prostate (HoLEP) using a 37.5 W holmium laser source.

Materials and methods: We retrospectively reviewed 713 patients with a diagnosis of benign prostatic hyperplasia (BPH) treated with HoLEP using an LP setting (37.5 W laser set to 1.5 J with a frequency of 25 Hz). All procedures were performed by experienced urologists. Functional outcomes, perioperative parameters, and complications were assessed over a 12-month follow-up period. Effect sizes (Cohen’s d) and 95% confidence intervals (CI) were calculated to …

Lumbar Disk Herniation Surgeries: The Impact Of Preoperative Holding Area Duration On Anxiety And Postoperative Pain ​, Zuhal Koç Apaydin, Hakan Kina

Turkish Journal of Medical Sciences

Background/aim: The purpose of this study is to investigate how anxiety levels are affected by preoperative holding area waiting times and how these fears affect pain following surgery. Patients waiting for surgery frequently suffer from preoperative anxiety, which can have an impact on how well they manage their postoperative pain.

Materials and methods: Forty-eight individuals with lumbar disc herniation scheduled for surgery participated in the study. Patients’ anxiety and pain levels were measured both during and after the preoperative holding area waiting period using the Amsterdam Preoperative Anxiety and Information Scale (APAIS), State-Trait Anxiety Inventory (STAI), and Visual Analog Scale …

Effect Of The Prognostic Nutritional Index On Stent Restenosis In Patients With Chronic Coronary Syndrome, Burak Kardeşler, Serdal Baştuğ, Kamuran Kalkan, Mehmet Erdoğan, Furkan Külekci̇, Muhammed Yunus Çalapkulu, Nur Beton, Abdullah Nabi̇ Aslan, Hafi̇ze Corut Güzel, Tahi̇r Durmaz

Turkish Journal of Medical Sciences

Background/aim: In-stent restenosis (ISR) remains a significant clinical challenge in patients undergoing percutaneous coronary interventions. We investigated the association between Prognostic Nutritional Index (PNI) and ISR in patients with chronic coronary syndrome.

Materials and methods: A total of 1007 patients who underwent coronary angiography for a provisional diagnosis of chronic coronary syndrome between March 1, 2019, and July 1, 2022, were included in the study. They were divided into two groups: ISR (n = 395) and non-ISR (n = 612). PNI was calculated using patients’ laboratory values before coronary angiography with the following formula: PNI = (10 × albumin (g/dL)) …

Cultural Adaptation And Psychometric Characteristics Of The Child Oral And Motor Proficiency Scale (Chomps)-Turkish Version, Ebru Umay, Si̇bel Eyi̇gör, Damla Cankurtaran, Sema Kalkan, Ni̇hal Tezel, Cuma Uz, Şükran Güzel, Fatma Balli Uz, Güler Gözpinar, Recep Gayir, Fatma Nazli, Keri̇m Demi̇rsöz, Ece Ünlü Akyüz, Britt Pados

Turkish Journal of Medical Sciences

Background/aim: The child oral and motor proficiency scale (ChOMPS) is a parent-reported assessment that evaluates a child’s eating and drinking skills within the framework of all related motor functions. It has been found to be useful in research studies and recommended in reviews. The purpose of this study was to perform the translation and cultural adaptation of the English version of the ChOMPS to Turkish and conduct psychometric testing of the ChOMPS–Turkish version, including reliability and validity.

Materials and methods: This study was conducted with 185 children. Cronbach’s α, corrected item-to-total correlations, coefficient of variation, and Cronbach’s α when one …

Impact Of Pulmonary Metastasectomy Timing And Nodule Characteristics On Survival Outcomes In Patients With Pediatric Sarcoma ​, İlteri̇ş Türk, Mehmet Çeti̇n, Neri̇man Sari, Selma Çakmakci, Necati̇ Solak, Fatma Babacan, Nesri̇n Gürçay, Pinar Biçakçioğlu

Turkish Journal of Medical Sciences

Background/aim: Pulmonary metastasectomy (PM) is a crucial intervention for patients with metastatic sarcomas, particularly among pediatric populations. The timing of PM and its impact on survival outcomes remain a subject of debate in the literature. This study aims to evaluate the impact of PM on survival outcomes.

Materials and methods: This retrospective study included pediatric patients diagnosed with sarcomas who underwent pulmonary metastasectomy. Demographic and clinical characteristics, including age, sex, primary malignancy type, metastasis presence at diagnosis, chemotherapy response, and PM details (e.g., number and laterality of metastatic nodules, time from metastasis detection to surgery) were analyzed. Survival data were …

Importance Of Sample Selection And Generalisability In Scientific Methodology ​, Egemen Ünal, Şefi̇k Yurdakul, Okan Maden

Turkish Journal of Medical Sciences

No abstract provided.