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Articles 3781 - 3810 of 24519
Full-Text Articles in Medicine and Health Sciences
J Am Coll Dent 2020 87 1
Journal of the American College of Dentists
The Journal of the American College of Dentists (JACD) publishes scholarly articles, editorials, essays, and reflections addressing the ethical, professional, and social dimensions of dentistry. The Journal serves as a forum for advancing ethics, professionalism, leadership, and excellence within the dental community. By fostering dialogue across disciplines and perspectives, JACD provides readers with insights that encourage ethical, professional practice, lifelong learning, and service to the public, reinforcing dentistry’s commitment to advancing oral healthcare and the common good.
J Am Coll Dent 2019 86 4
Journal of the American College of Dentists
The Journal of the American College of Dentists (JACD) publishes scholarly articles, editorials, essays, and reflections addressing the ethical, professional, and social dimensions of dentistry. The Journal serves as a forum for advancing ethics, professionalism, leadership, and excellence within the dental community. By fostering dialogue across disciplines and perspectives, JACD provides readers with insights that encourage ethical, professional practice, lifelong learning, and service to the public, reinforcing dentistry’s commitment to advancing oral healthcare and the common good.
J Am Coll Dent 2019 86 3
Journal of the American College of Dentists
The Journal of the American College of Dentists (JACD) publishes scholarly articles, editorials, essays, and reflections addressing the ethical, professional, and social dimensions of dentistry. The Journal serves as a forum for advancing ethics, professionalism, leadership, and excellence within the dental community. By fostering dialogue across disciplines and perspectives, JACD provides readers with insights that encourage ethical, professional practice, lifelong learning, and service to the public, reinforcing dentistry’s commitment to advancing oral healthcare and the common good.
J Am Coll Dent 2019 86 2
Journal of the American College of Dentists
The Journal of the American College of Dentists (JACD) publishes scholarly articles, editorials, essays, and reflections addressing the ethical, professional, and social dimensions of dentistry. The Journal serves as a forum for advancing ethics, professionalism, leadership, and excellence within the dental community. By fostering dialogue across disciplines and perspectives, JACD provides readers with insights that encourage ethical, professional practice, lifelong learning, and service to the public, reinforcing dentistry’s commitment to advancing oral healthcare and the common good.
J Am Coll Dent 2019 86 1
Journal of the American College of Dentists
The Journal of the American College of Dentists (JACD) publishes scholarly articles, editorials, essays, and reflections addressing the ethical, professional, and social dimensions of dentistry. The Journal serves as a forum for advancing ethics, professionalism, leadership, and excellence within the dental community. By fostering dialogue across disciplines and perspectives, JACD provides readers with insights that encourage ethical, professional practice, lifelong learning, and service to the public, reinforcing dentistry’s commitment to advancing oral healthcare and the common good.
J Am Coll Dent 2018 85 4
Journal of the American College of Dentists
The Journal of the American College of Dentists (JACD) publishes scholarly articles, editorials, essays, and reflections addressing the ethical, professional, and social dimensions of dentistry. The Journal serves as a forum for advancing ethics, professionalism, leadership, and excellence within the dental community. By fostering dialogue across disciplines and perspectives, JACD provides readers with insights that encourage ethical, professional practice, lifelong learning, and service to the public, reinforcing dentistry’s commitment to advancing oral healthcare and the common good.
J Am Coll Dent 2018 85 3
Journal of the American College of Dentists
The Journal of the American College of Dentists (JACD) publishes scholarly articles, editorials, essays, and reflections addressing the ethical, professional, and social dimensions of dentistry. The Journal serves as a forum for advancing ethics, professionalism, leadership, and excellence within the dental community. By fostering dialogue across disciplines and perspectives, JACD provides readers with insights that encourage ethical, professional practice, lifelong learning, and service to the public, reinforcing dentistry’s commitment to advancing oral healthcare and the common good.
J Am Coll Dent 2018 85 2
Journal of the American College of Dentists
The Journal of the American College of Dentists (JACD) publishes scholarly articles, editorials, essays, and reflections addressing the ethical, professional, and social dimensions of dentistry. The Journal serves as a forum for advancing ethics, professionalism, leadership, and excellence within the dental community. By fostering dialogue across disciplines and perspectives, JACD provides readers with insights that encourage ethical, professional practice, lifelong learning, and service to the public, reinforcing dentistry’s commitment to advancing oral healthcare and the common good.
J Am Coll Dent 2017 84 4
Journal of the American College of Dentists
The Journal of the American College of Dentists (JACD) publishes scholarly articles, editorials, essays, and reflections addressing the ethical, professional, and social dimensions of dentistry. The Journal serves as a forum for advancing ethics, professionalism, leadership, and excellence within the dental community. By fostering dialogue across disciplines and perspectives, JACD provides readers with insights that encourage ethical, professional practice, lifelong learning, and service to the public, reinforcing dentistry’s commitment to advancing oral healthcare and the common good.
J Am Coll Dent 2017 84 3
Journal of the American College of Dentists
The Journal of the American College of Dentists (JACD) publishes scholarly articles, editorials, essays, and reflections addressing the ethical, professional, and social dimensions of dentistry. The Journal serves as a forum for advancing ethics, professionalism, leadership, and excellence within the dental community. By fostering dialogue across disciplines and perspectives, JACD provides readers with insights that encourage ethical, professional practice, lifelong learning, and service to the public, reinforcing dentistry’s commitment to advancing oral healthcare and the common good.
J Am Coll Dent 2017 84 2
Journal of the American College of Dentists
The Journal of the American College of Dentists (JACD) publishes scholarly articles, editorials, essays, and reflections addressing the ethical, professional, and social dimensions of dentistry. The Journal serves as a forum for advancing ethics, professionalism, leadership, and excellence within the dental community. By fostering dialogue across disciplines and perspectives, JACD provides readers with insights that encourage ethical, professional practice, lifelong learning, and service to the public, reinforcing dentistry’s commitment to advancing oral healthcare and the common good.
J Am Coll Dent 2017 84 1
Journal of the American College of Dentists
The Journal of the American College of Dentists (JACD) publishes scholarly articles, editorials, essays, and reflections addressing the ethical, professional, and social dimensions of dentistry. The Journal serves as a forum for advancing ethics, professionalism, leadership, and excellence within the dental community. By fostering dialogue across disciplines and perspectives, JACD provides readers with insights that encourage ethical, professional practice, lifelong learning, and service to the public, reinforcing dentistry’s commitment to advancing oral healthcare and the common good.
Ultrasound Evaluation Of Left Ventricular Function In Coronary Artery Ectasia: The Added Value Of 2d Speckle-Tracking Echocardiography, Osama Abouelfetouh Elshaer, Mahmoud Gomaa, Ramy Magdy Elgamal, Mohamed Shokry Fahmy, Reda Nabil Dawoud, Reda Biomy, Ahmed Mostafa Ahmed, Mohamed Kamal Salama
Ultrasound Evaluation Of Left Ventricular Function In Coronary Artery Ectasia: The Added Value Of 2d Speckle-Tracking Echocardiography, Osama Abouelfetouh Elshaer, Mahmoud Gomaa, Ramy Magdy Elgamal, Mohamed Shokry Fahmy, Reda Nabil Dawoud, Reda Biomy, Ahmed Mostafa Ahmed, Mohamed Kamal Salama
Journal of the Saudi Heart Association
Introduction: Coronary artery ectasia (CAE) is defined as abnormal dilatation of coronary arteries and may be linked to subclinical myocardial dysfunction. Conventional echocardiographic parameters may not adequately detect early left ventricular (LV) dysfunction. Two-dimensional speckle-tracking echocardiography (2D STE) has shown promise in identifying subtle myocardial changes.
Methods: In this single-center observational study, 90 participants with available coronary angiography were divided into three groups: Group A (controls, n=30), Group B (single-vessel CAE, n=30), and Group C (multi-vessel CAE, n=30). Standard echocardiographic indices including LV ejection fraction (LVEF), volumes, and diastolic function were assessed. Global radial, longitudinal, circumferential, and area strains were …
Cv: Arvie Vitente (Physical Therapy), Arvie Vitente
Cv: Arvie Vitente (Physical Therapy), Arvie Vitente
Rehabilitation and Health Sciences Department Faculty Curricula Vitae
No abstract provided.
Scalable Biosynthesis And Recovery Of Poly-3-Hydroxybutyrate Produced From Cotton-Derived Glucose By Cupriavidus Necator, Ashley M. Clark, Lucia E. Gargano, Gabriella M. Fioravanti, Hannah M. Schapiro, Ron G. Kander
Scalable Biosynthesis And Recovery Of Poly-3-Hydroxybutyrate Produced From Cotton-Derived Glucose By Cupriavidus Necator, Ashley M. Clark, Lucia E. Gargano, Gabriella M. Fioravanti, Hannah M. Schapiro, Ron G. Kander
School of Design and Engineering Papers
To combat the growing issue of petroleum plastic waste, alternative bio-based polymers are being developed. Many of these biopolymers are made from bio-derived materials, or are biodegradable, but the most promising polymers fall in both categories. Polyhydroxyalkanoates (PHAs) are one such class of polymers, and poly-3-hydroxybutyrate (P3HB), the most popular PHA, has shown great potential. This study utilized two types of cotton-derived glucose, alongside commercial glucose, as a feedstock for the biosynthesis of P3HB by Cupriavidus necator (also known as Ralstonia eutropha). The fermentation took place in a 2-L bioreactor, showing potential for scale-up. A single-solvent extraction method was …
Housing Insecurity Is Associated With Higher Utilization Of Acute Care Services Among Oregon Health Plan Members With Behavioral Health Conditions, Megan Holtorf, Cat Livingston
Housing Insecurity Is Associated With Higher Utilization Of Acute Care Services Among Oregon Health Plan Members With Behavioral Health Conditions, Megan Holtorf, Cat Livingston
Articles, Abstracts, and Reports
No abstract provided.
Drug-Eluting Resorbable Scaffold Versus Balloon Angioplasty For Below-The-Knee Peripheral Artery Disease: 2-Year Results From The Life-Btk Trial., Brian G Derubertis, Ramon L Varcoe, Prakash Krishnan, Marc P Bonaca, David J O'Connor, Richard Pin, David C Metzger, Andrew Holden, Jen-Kuang Lee, Osamu Iida, Ehrin J Armstrong, Steven W C Kum, Raghu Kolluri, Danielle R Bajakian, Lawrence A Garcia, Mehdi H Shishehbor, Shawn Yu, Karine Ruster, Brad J Martinsen, Zsuzsanna Igyarto, Sahil A Parikh
Drug-Eluting Resorbable Scaffold Versus Balloon Angioplasty For Below-The-Knee Peripheral Artery Disease: 2-Year Results From The Life-Btk Trial., Brian G Derubertis, Ramon L Varcoe, Prakash Krishnan, Marc P Bonaca, David J O'Connor, Richard Pin, David C Metzger, Andrew Holden, Jen-Kuang Lee, Osamu Iida, Ehrin J Armstrong, Steven W C Kum, Raghu Kolluri, Danielle R Bajakian, Lawrence A Garcia, Mehdi H Shishehbor, Shawn Yu, Karine Ruster, Brad J Martinsen, Zsuzsanna Igyarto, Sahil A Parikh
Heart and Vascular Articles
BACKGROUND: Limited treatment options exist for infrapopliteal disease in patients with chronic limb-threatening ischemia (CLTI), a condition associated with a high risk of limb loss. Interventional management of diseased infrapopliteal vessels with percutaneous transluminal angioplasty (PTA) is associated with high rates of restenosis and reintervention. In the LIFE-BTK randomized controlled trial (Pivotal Investigation of Safety and Efficacy of BRS Treatment-Below the Knee), the drug-eluting resorbable scaffold (DRS) demonstrated superior 12-month efficacy compared with PTA in a selected CLTI population with predominantly noncomplex, mildly to moderately calcified lesions. This report presents the 2-year safety and efficacy outcomes of the Esprit BTK …
Quality Improvement Project: The Impact Of A Dedicated Education Unit On The Self-Efficacy Of First-Year Associate Degree Nursing Students, Danita Broussard
Quality Improvement Project: The Impact Of A Dedicated Education Unit On The Self-Efficacy Of First-Year Associate Degree Nursing Students, Danita Broussard
Doctor of Nursing Practice Projects
Nursing education continues to face challenges in preparing students to meet the complex demands of modern healthcare, particularly due to limited clinical placements and faculty shortages. This quality improvement project addressed the gap between classroom instruction and clinical practice by implementing a Dedicated Education Unit (DEU) model designed to impact students' self-efficacy. The purpose of this Doctor of Nursing Practice (DNP) project was to determine whether participation in a DEU impacted the self-efficacy of the first-year associate degree nursing students compared to the traditional clinical model. Guided by Bandura’s Self-Efficacy Theory and grounded in Evidence-Based Practice (EBP) principles, the project …
Knowledge And Attitudes About Epilepsy Of Neurology Outpatients In Türkiye, Ayşe Pinar Ti̇ti̇z, Abi̇di̇n Erdal, Yaren Ağar, Buse Altunbaşak
Knowledge And Attitudes About Epilepsy Of Neurology Outpatients In Türkiye, Ayşe Pinar Ti̇ti̇z, Abi̇di̇n Erdal, Yaren Ağar, Buse Altunbaşak
Turkish Journal of Medical Sciences
Background/aim: We aimed to evaluate the level of epilepsy-related knowledge and attitude among neurology outpatients without an epilepsy diagnosis.
Materials and methods: The Epilepsy Knowledge and Attitude Scale was applied to 331 adult patients who were evaluated with various diagnoses in the neurology outpatient clinic.
Results: The participants comprised 331 people, 51.4% of whom were women and 48.6% of whom were men. The knowledge and attitude values increase significantly as the education level of our participants increased (p < 0.001). The knowledge and attitude scores of those who knew about an individual with epilepsy were significantly higher (p < 0.001). Attitude scale scores were higher in patients diagnosed with headache, multiple sclerosis, syncope, Behçet’s disease, essential tremor and sleep disorders compared with other groups.
Conclusion: This study focused on a subgroup of adults without epilepsy who had other neurological conditions. The findings may illuminate the critical …
Anthropometric And Metabolic Assessment In Adults With Down Syndrome: The Need For Novel Indices And Tailored Criteria , Seli̇n Teki̇n, Nergi̇s Basmaci, İnci̇lay Lay, Alper Gürlek
Anthropometric And Metabolic Assessment In Adults With Down Syndrome: The Need For Novel Indices And Tailored Criteria , Seli̇n Teki̇n, Nergi̇s Basmaci, İnci̇lay Lay, Alper Gürlek
Turkish Journal of Medical Sciences
Background/aim: This study aimed to evaluate the metabolic profile of adults with Down syndrome (DS) using novel anthropometric and metabolic indices, while also highlighting the limitations of traditional obesity assessment methods compared with the non-DS population.
Materials and methods: This cross-sectional study included 22 adults with DS and 28 age- and sex-matched non-DS controls. Anthropometric measurements, including BMI, waist circumference (WC), and hip circumference (HC), were recorded alongside novel indices such as waist-to-height ratio (WHtR), body adiposity index (BAI), A body shape index (ABSI), and visceral adiposity index (VAI). Metabolic parameters (fasting plasma glucose, HbA1c, lipid profiles, HOMA-IR) and CBC-derived …
Association Between Nutritional Targets And Muscle Index Changes In Patients With Terminal Cancer Under Palliative Care , İrem Kiraç Utku, Burcu Çalişkan Aydoğmuş, Hati̇ce Nur Avcioğlu, Müge Çatikkaş, Ayfer Durak, Deni̇z Sevi̇ndi̇k Günay, Umut Safer
Association Between Nutritional Targets And Muscle Index Changes In Patients With Terminal Cancer Under Palliative Care , İrem Kiraç Utku, Burcu Çalişkan Aydoğmuş, Hati̇ce Nur Avcioğlu, Müge Çatikkaş, Ayfer Durak, Deni̇z Sevi̇ndi̇k Günay, Umut Safer
Turkish Journal of Medical Sciences
Background/aim: Malnutrition and muscle wasting are common in terminal cancer patients and adversely affect prognosis. Bedside muscle ultrasonography (US) has emerged as a practical tool to assess nutritional status and monitor therapy. This study evaluated the relationship between achieving individualized nutritional targets and changes in muscle indices measured by US in terminal cancer patients receiving palliative care.
Materials and methods: Subcutaneous fat tissue thickness (SFTT), muscle thickness (MT), and cross-sectional area (CSA) of the rectus femoris (RF) and biceps brachii (BB) muscles were assessed by US over 10 days and normalized to height squared (m²). A total of 95 …
Contribution Of Genetic Test Results To Patient Management In Ophthalmology: Results From A Turkish Stargardt Disease Cohort , Fulya Yaylacioğlu Tuncay, Şengül Özdek, Burak Acar, Gülsüm Kayhan, Murat Yüksel, Hüseyi̇n Baran Özdemi̇r, İhsan Gökhan Güreli̇k, Mehmet Ali̇ Ergün
Contribution Of Genetic Test Results To Patient Management In Ophthalmology: Results From A Turkish Stargardt Disease Cohort , Fulya Yaylacioğlu Tuncay, Şengül Özdek, Burak Acar, Gülsüm Kayhan, Murat Yüksel, Hüseyi̇n Baran Özdemi̇r, İhsan Gökhan Güreli̇k, Mehmet Ali̇ Ergün
Turkish Journal of Medical Sciences
Background/aim: The aim of the study was to analyze the genotype and phenotype characteristics of Turkish patients with a clinical diagnosis of Stargardt disease and to evaluate how collaboration between the departments of medical genetics and ophthalmology contributes to patient management.
Materials and methods: The clinical findings, genetic testing workflow in the medical genetics department, and the genetic testing results of patients clinically diagnosed with Stargardt disease in the ophthalmology department were retrospectively analyzed.
Results: The study included 50 patients from 46 families. The genetic test reports confirmed the clinical diagnosis of Stargardt disease type 1 (STGD1) in 27 patients …
Reliability Of Handheld Autorefractometers In Patients After Cataract Surgery , Ayça Küpeli̇ Çinar, Abdulkadi̇r Can Çinar, Hande Güçlü
Reliability Of Handheld Autorefractometers In Patients After Cataract Surgery , Ayça Küpeli̇ Çinar, Abdulkadi̇r Can Çinar, Hande Güçlü
Turkish Journal of Medical Sciences
Background/aim: Accurate postoperative refraction assessment is essential for optimal visual rehabilitation after cataract surgery. Although handheld autorefractometers (HH-ARMs) are widely used in pediatric and uncooperative patients, their reliability in adults after cataract surgery remains uncertain. This study compared refractive outcomes obtained with a HH-ARM (Mediworks V100; Mediworks, Guangzhou, China) and a TB-ARM (Canon RK-F2; Canon Inc., Tokyo, Japan) to evaluate the clinical applicability of HH-ARM in this population.
Materials and methods: This prospective study included 150 eyes of 150 patients (aged 55–85 years) who underwent uncomplicated phacoemulsification with intraocular lens (IOL) implantation. At 1 month postoperatively, spherical value (SV), cylindrical …
Validation Of The Turkish Version Of The Assessment Of Systemic Sclerosis-Associated Raynaud’S Phenomenon (Asrap) , Duygu Temi̇z Karadağ, Şeyma Yilmaz, Betül Di̇kkanoğlu Demi̇rok, John D. Pauling, Ayten Yazici, Ayşe Çefle
Validation Of The Turkish Version Of The Assessment Of Systemic Sclerosis-Associated Raynaud’S Phenomenon (Asrap) , Duygu Temi̇z Karadağ, Şeyma Yilmaz, Betül Di̇kkanoğlu Demi̇rok, John D. Pauling, Ayten Yazici, Ayşe Çefle
Turkish Journal of Medical Sciences
No abstract provided.
An Examination Of The Experiences Of An African American Male Diver On A Power Four Swim Team: An Elite Interview, Steven N. Waller Ph.D., Tiffany M. Quash Ph.D.
An Examination Of The Experiences Of An African American Male Diver On A Power Four Swim Team: An Elite Interview, Steven N. Waller Ph.D., Tiffany M. Quash Ph.D.
International Journal of Aquatic Research and Education
Despite the incremental increase in the number of Black people who are learning to swim, the number of Black divers has not kept pace. In the NCAA Database, swimmers and divers were not segmented; thus, they all appear in the category of “swimming” by race and sex. When viewing the 2024 Division I NCAA Demographics Database, 89 (.02%) of 4307 student-athletes participating in swimming were Black women. For men, the data is equally dismal, revealing that 81 (.03%) of 2,608 student-athletes who were identified as swimmers were Black. The purpose of this research note is to examine the developmental experiences …
Investigating Patient Non-Attendance To Healthcare Appointments In Türkiye: Data From A State Hospital And An Oral And Dental Health Center, Eyüp Sari, Ali̇ Ni̇yazi̇ Kurtcebe, Ci̇han Döğer, Recep Aydin
Investigating Patient Non-Attendance To Healthcare Appointments In Türkiye: Data From A State Hospital And An Oral And Dental Health Center, Eyüp Sari, Ali̇ Ni̇yazi̇ Kurtcebe, Ci̇han Döğer, Recep Aydin
Turkish Journal of Medical Sciences
Background/aim: To determine the frequency and reasons for appointment nonattendance in a state hospital and a dental health center in a densely populated district of Türkiye, and to identify related factors to guide preventive measures.
Materials and methods: This retrospective cross-sectional study included patients who scheduled appointments at Ankara Etimesgut State Hospital and Etimesgut Oral and Dental Health Center through the Centralized Patient Appointment System (Merkezi Hekim Randevu Sistemi; MHRS) in February 2024. Nonattendees were contacted in March 2024 to determine reasons for nonattendance.
Results: A total of 30,552 appointments were analyzed (1978 dental, 28,574 hospital). The overall nonattendance rate …
Fear Of Covid-19 And Hygiene Behaviors: A Study Of Secondary School Students In İstanbul , Zozan Göksu, Hayri̇ye Kirkoyun Uysal, Mehmet Demi̇rci̇, Di̇lek Dülger, Seda Eki̇ci̇
Fear Of Covid-19 And Hygiene Behaviors: A Study Of Secondary School Students In İstanbul , Zozan Göksu, Hayri̇ye Kirkoyun Uysal, Mehmet Demi̇rci̇, Di̇lek Dülger, Seda Eki̇ci̇
Turkish Journal of Medical Sciences
Background/aim: This study investigates the relationship between fear of COVID-19, measured using the Fear of COVID-19 Scale (FCV-19S), and the hygiene behaviors of secondary school students, assessed with the Hygiene Behavior Scale (HBS).
Materials and methods: Included in this cross-sectional study were 206 secondary school students. The study data were analyzed using multivariate linear regression.
Results: No relationship was found between the fear of COVID-19 scale (FCV-19S) score of the student sample and the mean total HBS and subdimension values (p > 0.05). It was noted that positive hygiene behaviors decreased as the scale score increased. Students with retired mothers scored …
Adult Adhd Is Linked To Higher Illicit Drug Use And Prescription Drug Misuse, Andrew S. London, Kevin M. Antshel, Joshua Grove, Iliya Gutin, Shannon M. Monnat
Adult Adhd Is Linked To Higher Illicit Drug Use And Prescription Drug Misuse, Andrew S. London, Kevin M. Antshel, Joshua Grove, Iliya Gutin, Shannon M. Monnat
Population Health Research Brief Series
Adolescents and young adults with Attention-Deficit/Hyperactivity Disorder (ADHD) are more likely than their peers without ADHD to use illicit drugs and misuse prescription drugs. This brief summarizes findings from a study that used data from the National Wellbeing Survey (NWS) to describe differences in lifetime and past-year use of 7 illicit drugs (marijuana, cocaine, crack cocaine, methamphetamine, heroin, fentanyl, and hallucinogens) and misuse of 4 categories of prescription medications (opioids, tranquilizers, sedatives, and stimulants) between U.S. adults ages 18-64 with and without self-reported healthcare provider-diagnosed ADHD in 2023. The authors find that adults with ADHD are 1.6 to 3.3 times …
Modeling Neurodegeneration In The Retina And Strategies For Developing Pan-Neurodegenerative Therapies, Emily L Ward, Aaron Diantonio, Et Al.
Modeling Neurodegeneration In The Retina And Strategies For Developing Pan-Neurodegenerative Therapies, Emily L Ward, Aaron Diantonio, Et Al.
2020-Current year OA Pubs
BACKGROUND: Glaucoma Research Foundation's third Catalyst for a Cure team (CFC3) was established in 2019 to uncover new therapies for glaucoma, a leading cause of blindness. In the 2021 meeting "Solving Neurodegeneration," (detailed in Mol Neurodegeneration 17(1), 2022) the team examined the failures of investigational monotherapies, issues with translatability, and other significant challenges faced when working with neurodegenerative disease models. They emphasized the need for novel, humanized models and proposed identifying commonalities across neurodegenerative diseases to support the creation of pan-neurodegenerative disease therapies. Since then, the fourth Catalyst for a Cure team (CFC4) was formed to explore commonalities between glaucoma …
Antibiotic Treatment Limits Survival Of Peripheral And Bone Marrow B-Cell Populations, Lila S Sanning, Forrest C Walker, Arushana A Maknojia, Leran Wang, Haina Jin, Gowri Kalugotla, Crystal Lovato, Katherine Y King, Megan T Baldridge
Antibiotic Treatment Limits Survival Of Peripheral And Bone Marrow B-Cell Populations, Lila S Sanning, Forrest C Walker, Arushana A Maknojia, Leran Wang, Haina Jin, Gowri Kalugotla, Crystal Lovato, Katherine Y King, Megan T Baldridge
2020-Current year OA Pubs
Prolonged or broad-spectrum antibiotic courses are associated with intestinal dysbiosis and cytopenias, and depletion of hematopoietic progenitor populations after antibiotics is associated with loss of peripheral immune cells, leading to increased susceptibility to systemic infections. We evaluated the bone marrow hematopoietic compartment in a murine model of antibiotic exposure. Single-cell RNA sequencing revealed a substantial and previously unrecognized depletion of bone marrow B cells at all stages of development in antibiotic-treated mice, further confirmed by flow cytometric analysis. Depletion of the microbiota was associated with rapid changes in the peripheral B-cell compartment, yet fecal microbiota transfer did not rescue either …