Medicine and Health Sciences Commons^™

Lair1 Prevents Excess Inflammatory Tissue Damage In Staphylococcus Aureus Skin Infection And Cutaneous T-Cell Lymphoma, Hannah K. Dorando, Evan C. Mutic, Kelly L. Tomaszewski, Yulia Korshunova, Ling Tian, Mellisa K. Stefanov, Chaz C. Quinn, Deborah J. Veis, Juliane Bubeck Wardenburg, Amy C. Musiek, Neha Mehta-Shah, Jacqueline E. Payton

2020-Current year OA Pubs

Patients with cutaneous T cell lymphoma (CTCL) experience high morbidity and mortality due to S. aureus skin infections and sepsis, but the underlying mechanisms remain unclear. We have previously identified high levels of LAIR2, a decoy protein for the inhibitory receptor LAIR1, in advanced CTCL. Mice lack a LAIR2 homolog, so we used Lair1 knock-out (KO) mice to model LAIR2 overexpression. In a model of S. aureus skin infection, Lair1 KO mice had significantly larger abscesses and areas of dermonecrosis compared to WT despite similar bacterial burdens. Lair1 KO exhibited a pattern of increased inflammatory responses in infection and sterile …

Targeting Tomm40 And Tomm22 To Rescue Statin-Impaired Mitochondrial Function, Dynamics, And Mitophagy In Skeletal Myotubes, Neil V Yang, Sean Rogers, Rachel Guerra, Justin Y Chao, David J Pagliarini, Elizabeth Theusch, Ronald M Krauss

2020-Current year OA Pubs

Statins are the drugs most commonly used for lowering plasma low-density lipoprotein (LDL) cholesterol levels and reducing cardiovascular disease risk. Although generally well-tolerated, statins can induce myopathy, a major cause of non-adherence to treatment. Impaired mitochondrial function has been implicated in the development of statin-induced myopathy, but the underlying mechanism remains unclear. We have shown that simvastatin downregulates the transcription of

What Are The Barriers And Facilitators To The Acceptance Of Information And Communication Technology-Based Interventions For Improving Resilience And Mental Health Of Healthcare Workers: A Scoping Review Protocol, Elisabete Alves, Ricardo Rodrigues, César Fonseca, Manuel Lopes, Inês Faria, Nina Dalkner, Paul Barach, Frans Folkvord, Jim Ingebretsen Carlson, Eva Reininghaus, Michele Wessa, Yvonne Prinzellner, Vanessa Leung, Eva Turk, Lara Guedes De Pinho

College of Population Health Faculty Papers

INTRODUCTION: Healthcare workers (HCWs) report overwhelming demands and experience crisis levels of burnout and unique challenges that further impair their mental health. Promotion of mental health among HCWs using information and communication technology (ICT) has received little empirical research attention and interventions for improving mental health resilience in HCWs are not well established.

DESIGN: Scoping review to map existing evidence and identify gaps for future research regarding the main barriers and facilitators of the acceptance of ICT-based interventions for improving resilience and mental health among HCWs working in all healthcare settings.

METHODS AND ANALYSIS: This protocol was developed in accordance …

State-Level Progress And Setbacks In Influenza Vaccination Among Adults ≥65: A Fifteen-Season Analysis From 2009/10 To 2023/24, Luigi Russo, Sara Farina, Raffaele Angelo Macri, William Alan Pentecost, Alessandra Maio, Leonardo Villani, Vittorio Maio, Stefania Boccia, Walter Ricciardi

College of Population Health Faculty Papers

INTRODUCTION: Influenza is a contagious respiratory infection with substantial health and economic consequences worldwide. Annual vaccination is the most effective preventive strategy; however, coverage among older adults remains suboptimal and varies considerably across the United States. This study aimed to examine state-level trends in influenza vaccination coverage among adults aged ≥65 years across fifteen influenza seasons (2009/10-2023/24).

METHODS: State-level vaccination coverage data for adults aged ≥65 years were obtained from the CDC FluVaxView platform, which reports annual estimates by influenza season. The analysis covered the 2009/10 through 2023/24 influenza seasons. Joinpoint regression was used to assess temporal trends and estimate …

Survey On Preparedness And Readiness For Technological Advancements In Ai Sparta Ai, Jegason Phosphorus Diviant

Population Health Research and Scholarship

Generative AI is rapidly entering academic workflows, yet readiness to use these tools in graduate training and the workplace remains unclear. The SPARTA AI was administered online to faculty and graduate students in the University of New Mexico’s Psychology Department and COPH (Feb–Sep 2025). The analytic sample included N=37 respondents. Descriptives, role-stratified academic AI usage, one-sample tests of perceived preparedness vs a 3.0 midpoint, and correlations between AI interest and academic usage were computed; Wilson CIs were used for proportions. The sample comprised 20 faculty and 17 graduate students, primarily from COPH and Psychology. AI usage was generally infrequent across …

A Credibility-Driven Evaluation Of A Community-Based Perinatal Substance Use Disorder Collaborative Care Model, Christina M. Jäderholm, Teshanee T. Williams, Brad M. Wipfli, Lynne C. Messer, Liana B. Winett

OHSU-PSU School of Public Health Faculty Publications and Presentations

Introduction:

Effectively treating substance use disorder (SUD) during pregnancy is critical to preventing adverse health outcomes for both parents and children, including overdose death and family separation. Although evidence supports investing in parental recovery through comprehensive care and support, these approaches remain under-examined, with community perspectives often marginalized due to evaluation challenges. This study evaluated the Substance Use Network (SUN) program, a community-based perinatal SUD recovery model in North Carolina.MethodsWe used a patient-focused journey mapping approach to assess participant engagement, health outcomes, and alignment between participant and provider experiences. The evaluation used a mixed-methods approach, incorporating participant medical record review …

Rabies Virus-Vectored Lyme Disease Vaccine Provides Long-Term Protection Against Tick-Transmitted Borrelia Burgdorferi, Shantel Rios, Bibek Bhattachan, Christoph Wirblich, Anisha Chandwani, Kruthi Vavilikolanu, Jacob F. Myers, Chrysoula Kitsou, Utpal Pal, Matthias J. Schnell

Department of Microbiology and Immunology Faculty Papers

Lyme disease (LD) cases have doubled globally. LD is a tick-borne illness caused by the Borrelia burgdorferi sensu lato (Bb). If untreated, Bb can disseminate to distal organs, causing carditis, arthritis, and meningitis. Currently, no FDA-approved human LD vaccine exists on the market. This study used two approaches to incorporate OspA into the rabies virus (RABV) vaccine vector. We used the RABV-glycoprotein tail (RVG tail) and the Hendra virus (HeV) glycoprotein tail (HVG tail) to incorporate OspA, creating BNSP333-OspA-RVG and BNSP333-OspA-HVG, respectively. Both vaccines produced type-1 biased anti-OspA antibodies, but only BNSP333-OspA-HVG induced neutralizing antibodies and protected against Bb infection. …

Bridging The Knowledge Gap Of Nursing Staff Understanding Patient Medication Discharge Instructions, Tracy L. Outlaw

Walden Dissertations and Doctoral Studies

The project, a Doctor of Nursing Practice (DNP) staff education project, addresses a gap in nursing practice by focusing on the need for comprehensive knowledge and effective communication skills among nursing staff regarding antidepressant discharge instructions. The practice-focused question is as follows: How does a structured educational program on antidepressant pharmacology and communication strategies impact staff knowledge and satisfaction compared to standard discharge practices? The primary purpose of the project is to improve nursing staff knowledge and communication through a systematic, phased approach that aligns with project management principles through the lens of project management theory, thereby increasing and sustaining …

Impact Of Staff Education On Cultural Competency Knowledge And Skills, Okechukwu Cyril Akunwafor

Walden Dissertations and Doctoral Studies

Summary The Doctor of Nursing Practice (DNP) project involved implementing a cultural competency staff education program at an outpatient mental health clinic. The identified practice problem was poor cultural competence practices knowledge among staff, resulting in poor patient engagement and a low patient satisfaction rate. Improving cultural competency in nursing practice was necessary to facilitate therapeutic trust, increase patient treatment adherence, and enhance staff compliance with Culturally and Linguistically Appropriate Services (CLAS). The practice-focused question guiding the DNP project was: Does implementing staff education impact their knowledge of cultural competence and confidence in adhering to CLAS? Data were collected through …

Staff Education To Improve Cultural Competence In Mental Health Care, Mariam Farah

Walden Dissertations and Doctoral Studies

This doctoral project addressed a gap in staff cultural competence at a mental health and addiction services center in the Midwest. I conducted this project to design, implement, and evaluate a staff educational program to improve staff knowledge, cultural awareness, and communication skills. The guiding practice-focused question was: Among staff at the Midwest mental health and addiction services center, how does a structured cultural competence education program compare to current practices in improving staff knowledge of cultural awareness? A 2-day educational session was held to accommodate participation within regular work schedules without interfering with the project site organization’s services. Arrangements …

Prevalence Of Potentially Inappropriate Medications In People Living With Hiv: A Systematic Review And Meta-Analysis, Mustapha Muhammed Abubakar, Abdulmuminu Isah, Ruth Jeminiwa, Ibraheem Abioye, Ismaeel Yunusa, Mohammed Abba-Aji, Osagie Kenneth Cole, Jamila Sani, Mukhtar Ijaiya, Chukwuemeka Nwachuya, Yusuf Ibrahim, Mustapha Usman, Duke Daniels, Oluwaseun Samuel Ilugbuhi, Blessing Onyinye Ukoha-Kalu

College of Pharmacy Faculty Papers

BACKGROUND: Potentially inappropriate medications (PIM) are associated with adverse health outcomes. The use of PIM among persons living with HIV (PLHIV) could be more problematic due to peculiarities such as antiretroviral toxicity and drug-disease interactions. However, PIM among PLHIV continues to receive little attention. Therefore, we aimed to systematically review and estimate the prevalence of PIM among PLHIV.

METHODS: We searched the PubMed, Scopus, and Web of Science databases to identify relevant studies from 1 January 2014 to 30 June 2024. Studies included were peer-reviewed articles that determined PIM prevalence using validated explicit or implicit tools and provided statistical information …

Bridging The Gap: Improving Medication Communication Through The Teach-Back Method At Discharge, Sangeeta Biju Varghese

Doctoral Dissertations and Projects

Patient experience and hospital readmission rates are both key performance indicators in value-based reimbursement, as defined by the Centers for Medicare & Medicaid Services. Both these indicators have a negative impact not only on patients but also on hospital profitability, and they are closely tied to discharge education. Lack of proper discharge instructions, especially about medication regimen, can result in adverse effects in patients post-discharge, which could have been prevented had they gotten adequate discharge instructions. Research has shown that almost 20% of patients leaving the hospital have an adverse drug event after discharge. Nurses have a key role in …

Visualized Shared Mental Modeling: An Adapted Practical Framework For Interdisciplinary Teams Solving Complex Problems In Healthcare, Milan F. Satcher, Asha L. Dees, Joshua M. Johnston, Amro M. Farid, Inas S. Khayal

Dartmouth Scholarship

Healthcare systems and the scientific community are increasingly recognizing the need for multidisciplinary, inter-organizational perspectives and skill sets to tackle the most pressing challenges of our time to improve human health. However, as our approach to scientific inquiry is evolving, our methods of working across teams remain largely unchanged. Using a case example of a human-centered design project focused on improving care transitions during reentry to the community from incarceration, this paper details the importance and function of visualized shared mental models for multidisciplinary teams addressing complex multisystem problems. This paper contributes a practical framework for developing a stakeholder-validated, visualized …

Efficacy Of Medical-Legal Partnerships To Address Health-Harming Legal Needs: A Systematic Review Of Experimental Studies In The Field, Jemima John, Thomas Murphy, Emily Zientek, Winston Liaw, Odinakachukwu Dimgba, Thien-An Nguyen, Catherine Burnett, Mary Aitken, Shreela Sharma

Faculty, Staff and Student Publications

Background: Despite the documented success of medical-legal partnerships (MLPs), there is a dearth of robust experimental-based research on their efficacy. This review synthesizes the findings of MLP interventions and identifies opportunities for MLP expansion in vulnerable communities.

Methods: Articles were eligible if they tested the experimental effects of an MLP intervention on health-harming legal needs (HHLNs) and had full text for review. Two reviewers independently screened articles for inclusion and assessed the quality (risk of bias) of each study.

Results: Seven studies were eligible. Populations were largely women, of color, and of lower socioeconomic status. All studies demonstrated positive effects …

Latent Classification Of Time-Dependent Transition Rates In Longitudinal Binary Outcome Data, Joonha Chang, Wenyaw Chan

School of Public Health Faculty Publications

Continuous-time Markov chain (CTMC) models and latent classification methods are commonly used to analyze longitudinal categorical outcomes in medical research. While CTMC models are popular for their simplicity and effectiveness, their assumption of constant transition rates presents limitations in capturing dynamic behaviors. To address this, non-homogeneous continuous-time Markov chains (NH-CTMCs) have been developed, incorporating time-varying transition rates to enhance model flexibility. In this study, we leverage closed-form transition probabilities for a fully ergodic two-state NH-CTMC model and propose a latent class clustering approach to identify heterogeneous transition rate patterns within the population. We emphasize the potential advantages of these models …

Developing A General Ai Model For Integrating Diverse Genomic Modalities And Comprehensive Genomic Knowledge, Zhenhao Zhang, Xinyu Bao, Linghua Jiang, Xin Luo, Zheyu Zhang, Jing Yin, Meiqi Zhao, Yichun Wang, Annelise Comai, Joerg Waldhaus, Anders S Hansen, Wenbo Li, Jie Liu

Faculty, Staff and Student Publications

Advances in next-generation sequencing technologies have vastly expanded the availability of diverse genomic, epigenomic, and transcriptomic data, presenting the opportunity to develop a general AI model that integrates comprehensive genomic knowledge into a unified model. Unlike previous predictive models, which are typically specialized to certain tasks, our general AI model unifies a wide range of genomic modalities, such as nascent RNA and ultra-high-resolution chromatin organization, within a multi-task architecture. Using ATAC-seq and DNA sequences as inputs, we incorporated diverse genomic modalities as output, and the model exhibits strong generalizability across different cell types and tissues in all tasks we trained. …

The Unfolded Protein Response-Novel Mechanisms, Challenges, And Key Considerations For Therapeutic Intervention, P M Quan Mai, Tam-Anh Truong, Sai Kumar Samala, Bhoomika Muruvekere Lakshmisha, Prapannajeet Biswal, Khadijeh Koushki, Prudhvi Chand Mallepaddi, Geraldine Vijay, Sunil Krishnan

Faculty, Staff and Student Publications

Background: The unfolded protein response (UPR) is an evolutionarily conserved, synchronized, and orchestrated process triggered by eukaryotic cells in response to endoplasmic reticulum (ER) stress. UPR restores the ER's capacity to handle large protein loads within it, and still fold and process these proteins accurately. Many recent studies have documented the non-canonical roles of the UPR, outside of protein quality control, in the context of lipid metabolism and the immune system in cancer. Cancer cells have been known to hijack the UPR to promote survival and evade immune surveillance. However, the underlying mechanisms remain poorly understood.

Objectives: Here, we critically …

Primary Intramedullary Spinal Melanocytomas: Case Report And Review Of Clinical Features, Diagnosis, And Management, Gil Kimchi, Samantha Varela, Juan Pablo Zuluaga-Garcia, Francisco Call-Orellana, Esteban Ramirez Ferrer, Romulo Augusto Andrade De Almeida, Maria A Gubbiotti, Isabella C Glitza, Andrew J Bishop, Jonathan D Grant, Robert Y North, Christopher A Alvarez-Breckenridge, Laurence D Rhines, Claudio E Tatsui

Faculty, Staff and Student Publications

Objective: Intramedullary melanocytomas are extremely rare spinal cord tumors with distinct histopathological and imaging characteristics. This report reviews the literature on this pathology and presents a representative case study, highlighting aspects of diagnosis and management.

Methods: A scoping review of PubMed, Web of Science, and Embase databases was conducted to identify reports on intramedullary melanocytomas, focusing on clinical presentation, imaging features, histopathology, treatment, and outcomes. Case reports and case series were included due to the rarity of these tumors.

Results: Twelve manuscripts met the inclusion criteria, including 15 patients. In the majority of patients, intramedullary melanocytomas present with progressive myelopathy …

Countermovement Jump Force Plate Metrics As Neuromuscular Indicators For Seasonal Micro-Adaptations And Hitting Performance Variability In Professional Baseball, Brandon Russell Pentheny

Doctoral Dissertations and Projects

This dissertation explored the use of countermovement jump (CMJ) force plate metrics as indicators of neuromuscular status and their relationship to hitting performance variability across a competitive season in professional baseball. Although there is an increase in the integration of sports science and performance analytics in professional sports, a significant gap remains in longitudinal, in-season monitoring models that connect neuromuscular adaptations to hitting-specific outputs, such as bat velocity and ball exit velocity (BEV). This study examined lower-body force production as measured by uniaxial bilateral force plates and how they interact with hitting output task demands over time. Using a longitudinal …

A Phenomenological Exploration Of Respiratory Therapists’ Perceptions On Potential Degree Requirements, John Wayne Lindsey Jr.

Doctoral Dissertations and Projects

The purpose of this phenomenological study was to explore the lived experiences of respiratory therapists (RTs) regarding the proposed transition from an associate’s degree (ASRT) to a bachelor’s degree (BSRT) as the minimum entry-level credential for the respiratory therapy profession. The respiratory therapy profession faces significant educational challenges due to the increasingly advanced requirements for evidence-based practice (EBP) and teamwork across multiple healthcare disciplines. The theoretical framework for this study was based on three interrelated theories: Kolb’s Experiential Learning Theory, Knowles’ Adult Learning Theory, and Benner’s Novice to Expert Model. Together, these theories established solid groundwork for exploring how RTs …

Separating The Wheat From The Chaff: A Quantitative Pilot Study Of Biblical Christian Spirituality As A Regulator Of Dark Triad Personality Traits, Patricia L. Elston

Doctoral Dissertations and Projects

A review of the psychological literature on Christianity as a regulator of Dark Triad personality traits over the last 25 years revealed just a handful of quantitative and qualitative studies that relied exclusively upon long-standardized constructs drawn from cultural Christian ideology. Such constructs remain in direct contrast to biblical tenets to opine that Christianity has no important impact upon the development and persistence of highly aversive Dark Triad social attributes. The current quantitative pilot study was conducted in a small sample (n=26) of adult male and female born-again members of an international Evangelical Christian motorcycle ministry whose primary recruitment is …

The Lived Psychosocial Experiences Of Nursing Students Transitioning From In-Person Learning To Virtual Learning: A Transcendental Phenomenological Study, Lesley I. Gerald-Koram

Doctoral Dissertations and Projects

The purpose of this transcendental phenomenological study was to explore and understand the lived psychosocial experiences of nursing students who transitioned from in-person learning to virtual learning at the onset of the COVID-19 pandemic in the northeast region. The study comprised of 15 participants who were enrolled in accredited nursing programs across New York, who experienced the abrupt shift in learning platforms during a global crisis. The abrupt shift significantly affected the emotional, academic, and professional development of the nursing students. This research was rooted in the growing concern of nursing student mental health, academic engagement, and preparation for clinical …

Culture-Independent Meta-Pangenomics Enabled By Long-Read Metagenomics Reveals Associations With Pediatric Undernutrition, Jeremiah J Minich, Nicholas Allsing, M Omar Din, Michael J Tisza, Kenneth Maleta, Daniel Mcdonald, Nolan Hartwick, Allen Mamerto, Caitriona Brennan, Lauren Hansen, Justin Shaffer, Emily R Murray, Tiffany Duong, Rob Knight, Kevin Stephenson, Mark J Manary, Todd P Michael

Faculty, Staff and Students Publications

The human gut microbiome is linked to child malnutrition, yet traditional microbiome approaches lack resolution. We hypothesized that complete metagenome-assembled genomes (cMAGs), recovered through long-read (LR) DNA sequencing, would enable pangenome and microbial genome-wide association study (GWAS) analyses to identify microbial genetic associations with child linear growth. LR methods produced 44-64× more cMAGs per gigabase pair (Gbp) than short-read methods, with PacBio (PB) yielding the most accurate and cost-effective assemblies. In a Malawian longitudinal pediatric cohort, we generated 986 cMAGs (839 circular) from 47 samples and applied this database to an expanded set of 210 samples. Machine learning identified species …

The American Dermatological Association And The Story Of American Dermatology, Thomas N. Helm, Lawrence C. Parish, Amy S. Paller, David M. Pariser

Department of Dermatology and Cutaneous Biology Faculty Papers

No abstract provided.

Culture-Independent Meta-Pangenomics Enabled By Long-Read Metagenomics Reveals Associations With Pediatric Undernutrition, Jeremiah J Minich, Nicholas Allsing, M Omar Din, Michael J Tisza, Kenneth Maleta, Daniel Mcdonald, Nolan Hartwick, Allen Mamerto, Caitriona Brennan, Lauren Hansen, Justin Shaffer, Emily R Murray, Tiffany Duong, Rob Knight, Kevin Stephenson, Mark J Manary, Todd P Michael

Faculty, Staff and Students Publications

The human gut microbiome is linked to child malnutrition, yet traditional microbiome approaches lack resolution. We hypothesized that complete metagenome-assembled genomes (cMAGs), recovered through long-read (LR) DNA sequencing, would enable pangenome and microbial genome-wide association study (GWAS) analyses to identify microbial genetic associations with child linear growth. LR methods produced 44-64× more cMAGs per gigabase pair (Gbp) than short-read methods, with PacBio (PB) yielding the most accurate and cost-effective assemblies. In a Malawian longitudinal pediatric cohort, we generated 986 cMAGs (839 circular) from 47 samples and applied this database to an expanded set of 210 samples. Machine learning identified species …

A Practical Primer On How To Detect And Treat Depression In Ckd, L Parker Gregg, Lynnel Goodman, Ella Q Carroll, S Susan Hedayati

Faculty, Staff and Students Publications

Detection and management of depression have special considerations in people with kidney disease. Screening should be done every 6-12 months using a self-reported questionnaire. Clinicians should rule out symptoms from medical conditions such as dialysis inadequacy or hypothyroidism and confirm the presence of sadness or anhedonia. Sertraline has shown limited efficacy and an increased risk for adverse effects such as gastrointestinal symptoms, so cautious, gradual dose titration is warranted. Cognitive behavioral therapy has potential benefit for depressive symptoms in people with kidney disease. Current trials are evaluating behavioral activation therapy. Physical activity has many benefits and likely improves depression.

Design, Optimization, And Development Of Ripk1 Degraders With Improved Pharmacokinetic And Pharmacodynamic Properties, Dong Lu, Xin Yu, Hanfeng Lin, Ran Cheng, Bin Yang, Min Zhang, Jingjing Chen, Feng Li, Xiaoli Qi, Jin Wang

Faculty, Staff and Students Publications

Pharmacological degradation of receptor-interacting protein kinase 1 (RIPK1) offers a compelling therapeutic strategy to overcome its scaffolding role in tumor resistance and to enhance the efficacy of immune checkpoint blockade (ICB) therapies. In this study, we report the discovery of a novel RIPK1 degrader, LD5097(24b), developed through systematic optimization of its precursor compound, LD4172—specifically refining the linker, RIPK1 warhead exit vector, and VHL ligand components. LD5097(24b) exhibits potent and selective RIPK1 degradation, triggering rapid and efficient downregulation of RIPK1 and significantly enhancing TNFα-mediated apoptosis in Jurkat cells. Compared to LD4172, LD5097(24b) demonstrates markedly improved metabolic stability and pharmacokinetic properties. In …

Genetic And Embryonic Transcriptome Analyses Reveal The Molecular And Developmental Basis Of Mayer-Rokitansky-Küster-Hauser Syndrome, Na Chen, Xi Cheng, Sen Zhao, Hengqiang Zhao, Chenglu Qin, Yaru Zhang, Xijuan Lin, Qing Li, Yuan Wang, Jia Kang, Jing Yu, Jianbin Guo, Qianqian Gao, Jiali Duan, Yuchen Niu, Jianzhong Su, Zhihong Wu, Terry Jianguo Zhang, Wanlu Liu, Pengfei Liu, Shan Deng, Nan Wu, Lan Zhu

Faculty, Staff and Students Publications

Background: Mayer-Rokitansky-Küster-Hauser syndrome (MRKHS) is characterised by aplasia of the uterus, cervix and upper part of the vagina. The genetic aetiology remains incompletely understood.

Methods: We performed gene-level and gene set-level burden analyses based on exome sequencing/genome sequencing data from 727 probands with MRKHS and 2504 female control individuals. Single-cell RNA sequencing (scRNA-seq) was performed on human and mouse embryonic metanephros at different developmental stages. Genetic and transcriptomic data were integrated to prioritise suboptimal genetic signals, identify relevant cell types and determine key developmental stages. Potential digenic inheritance was assessed and prioritised using coexpression patterns from scRNA-seq data.

Results: We …

Collaborative Learning In Occupational Therapy Graduate Education: Student And Faculty Perspectives, Erin Simpson, Caren Schranz

Journal of Applied Disciplines

Collaborative learning is noted as an effective strategy for learning and engagement in graduate school. Collaborative learning specific to occupational therapy (OT) graduate learning supports opportunities to work with peers and prepare for professional practice by expanding critical thinking, interpersonal and teamwork skills. This study explored the benefits and challenges of collaborative learning in occupational therapy graduate programs from the perspective of both students and faculty. A cross-sectional descriptive design gathered student and faculty perspectives through closed and open-ended questions. Data analyzation used descriptive statistics of close-ended questions and content analysis of open-ended questions using frequency of the words or …

Single Vs. Whole Muscle Group Assessments: Does The Specific Muscle Influence Its Association With Performance?, Carina M. Velasquez, Kealey J. Wohlgemuth, Mckenzie M. Hare, Kathryn E. Southall, Jacob A. Mota

Topics in Exercise Science and Kinesiology

Topics in Exercise Science and Kinesiology Volume 6: Issue 1, Article 11, 2025. Biometric Muscle size and echo intensity are thought to influence muscle function. Unfortunately, previous works often will examine a single muscle from a group of agonists as a metric of whole muscle performance. This approach may not always be the most appropriate to assess performance outcomes. The purpose of the study was to 1) quantify the association of muscle size and echo intensity with vertical jump performance (VJ), 2) Compare the associations between individual and whole muscle group size and echo intensity, 3) determine whether single or …