Medicine and Health Sciences Commons^™

Human Serum Albumin Interaction With Organochlorine Pesticides, D. S. Sanford, R. Yadav, A. Mishra

Journal of the Arkansas Academy of Science

Human serum albumin (HSA) is the most abundant blood plasma protein and plays a crucial role in drug transport and physiological homeostasis. HSA has a highly flexible structure consisting of three domains, each with multiple binding sites lined with hydrophobic and hydrophilic residues. The structural properties of HSA make it a robust reservoir and receptor for various endogenous and exogenous compounds, including therapeutic drugs. Organochlorine pesticides (OCPs) are a subclass of pesticides characterized by their chlorine content. Once widely used, these compounds remain persistent in the environment and biological systems despite regulatory restrictions in many developed countries. The strong ligand-binding …

Comparison Of Machine Learning Models For Colon Cancer Survival: Predictive Modeling Approach, Reuben Adatorwovor, Motolani E. Ogunsanya, Bin Huang, Richard Charnigo, Olufunmilola Abraham

Biostatistics Faculty Publications

Background: Colon cancer is a leading cause of cancer-related deaths worldwide, with survival influenced by risk factors, treatment type, and patient characteristics. Traditional statistical models, such as Kaplan-Meier curves, have been widely used to estimate survival probabilities. However, these models often have difficulty handling complex interactions, covariates, and nonlinear relationships between risk factors. Recently, machine learning (ML) techniques have emerged as promising tools for improving survival prediction by handling large covariates and capturing complex patterns.

Objective: This study compares several ML models to accurately estimate colon cancer survival by leveraging data from the Kentucky Cancer Registry. By identifying key risk …

Athletic Training Students' Use Of Health Information Technology Professional Behaviors During Clinical Experiences: A Report From The Aate Research Network, Cailee E. Welch Bacon, Julie M. Cavallario, Stacy E. Walker, R. Curtis Bay, Bonnie L. Van Lunen

Rehabilitation Sciences Faculty Publications

Context:

As an essential core competency for high-quality healthcare, health information technology (HIT) leverages the use of technology, such as electronic record systems, to collect and use patient care information to make informed clinical decisions. There is a dearth of information regarding professional athletic training students' (ATSs') use of HIT professional behaviors during clinical experiences.

Objective:

To assess HIT professional behaviors ATSs engage with during clinical experience patient encounters (PEs). DESIGN: Multisite panel design.

Setting:

12 professional athletic training programs.

Participants:

363 ATSs enrolled across the participating professional athletic training programs entered patient encounter information within E*Value during their scheduled …

The Impact Of Social Participation Through Adaptive Sports On Quality Of Life In Individuals With Spinal Cord Injury, Mikayla Martin, Zeida Gutierrez

Spring 2025 OTD Capstone Symposium

This project researched and explored how socialization through adaptive sports in this case impacts the perception of quality of life among individuals who have sustained a spinal cord injury.

Reply [To Burnout Reflections: Musings On Bianchi And Schonfeld’S Five Focal Areas], Renzo Bianchi, Irvin Sam Schonfeld

Publications and Research

Contrary to what one might assume, the burnout construct did not emerge from systematic research. The definition of burnout was formulated in the 1970s based on prenotions and anecdotal evidence. No sound empirical studies, no in-depth theoretical reflections, not even a review of the stress literature underpinned the introduction of the construct. It is thus unsurprising that some observers regard the edifice of burnout research with scepticism. The pioneers of burnout research neglected basic scientific standards and, by overlooking the abundant work of contemporary stress researchers, deprived themselves of important safeguards against illusions of novelty making big claims based on …

Additional Evidence From A Case Report Supports A Novel Hypothesis On The Association Between Complex Regional Pain Syndrome And Lymphedema, M Mark Melin, John C Rasmussen, Melissa B Aldrich, Ron J Karni, Caroline E Fife, Kristen A Eckert

The Brown Foundation: Institute of Molecular Medicine

A previous report of 4 heterogeneous cases demonstrated that automated manual lymphatic drainage therapy (AMLDT), administered by a novel, pneumatic mat of 16 pressurized air channels that inflate and deflate sequentially to mimic the stretch and release action of manual lymphatic drainage therapy (MLD), altered lymphatic contractility and relieved pain. Near-infrared fluorescence imaging (NIRF-LI) was used 1 h before AMLDT, during 1 h of AMDLT, and 30-60 min after treatment to obtain images that could be used to determine lymphatic contractility, as measured by pulsing frequency over a given timeframe. Herein, a case of type 2 complex regional pain syndrome …

Editorial: Advances In Pharmacotherapy For Alcohol Use Disorder: From Mechanisms To Clinical Interventions, Regina A Mangieri, Sunil Sirohi, Ezequiel Marron Fernandez De Velasco, Seungwoo Kang

The Brown Foundation: Institute of Molecular Medicine

No abstract provided.

Microglial Trem2 Promotes Phagocytic Clearance Of Damaged Neurons After Status Epilepticus, Dale B Bosco, Vaclav Kremen, Koichiro Haruwaka, Shunyi Zhao, Lingxiao Wang, Blake A Ebner, Jiaying Zheng, Manling Xie, Aastha Dheer, Jadyn F Perry, Abhijeet Barath, Aivi T Nguyen, Gregory A Worrell, Long-Jun Wu

The Brown Foundation: Institute of Molecular Medicine

In the central nervous system, triggering receptor expressed on myeloid cells 2 (TREM2) is exclusively expressed by microglia and is critical for microglial proliferation, migration, and phagocytosis. Microglial TREM2 plays an important role in neurodegenerative diseases, such as Alzheimer's disease and amyotrophic lateral sclerosis. However, little is known about how TREM2 affects microglial function within epileptogenesis. To investigate this, we utilized male TREM2 knockout (KO) mice within the intra-amygdala kainic acid seizure model. Electroencephalographic analysis, immunocytochemistry, and RNA sequencing revealed that TREM2 deficiency significantly promoted seizure-induced pathology. We found that TREM2 KO increased both the severity of acute status epilepticus …

Menstrual Cycle Phase Effects On Exercise Thermoregulation And Performance In The Heat, Kailei J. Eustis

All Master's Theses

Hormone fluctuations across the menstrual cycle (MC) may influence physiological responses. This study examined whether thermoregulatory measures differ across MC phases, and if these changes impact running performance in the heat. Ten eumenorrheic adults completed two treadmill runs in simulated conditions (wet bulb globe temperature 31.7 ± 1.4°C) during early follicular (EF) and midluteal (ML) phases. First 45min was a constant self-selected light pace followed by a 15min performance test for distance. Core temperature (Tc), mean skin temperature (Ts), heart rate (HR), perceived exertion (RPE), thermal perception (THERM), and comfort perception (COMF) were assessed every 5min. Sweat perception (SP), sweat …

Is Pathogen Molecular Testing Reshaping Outpatient Antibiotic Prescribing?, Barbara D. Alexander, William D. Irish, Adriana E. Rosato, Barry I. Eisenstein, Maren S. Fragala, Steven E. Goldberg, David B. Nash

College of Population Health Faculty Papers

No abstract provided.

Impact Of Trauma-Informed Care In Higher Education, Lauren Mochnal

Student Research Design & Innovation Symposium

Trauma is prevalent among students in higher education, with 66% to 85% of university students having experienced a traumatic event (Wells et al., 2021). Additionally, college students in the United States currently report greater psychological distress and mental health challenges than in the past (Ray et al., 2024). Traumatic experiences can lead to challenges in emotional regulation, delayed brain development, and increased risk of adverse health outcomes and academic failure (Gao et al., 2023). However, use of a trauma-informed care approach to higher education at both a departmental and classroom level can minimize barriers and improve occupational engagement in education, …

The Association Between Insomnia & Porn Addiction, Sheriyah Hicks

Student Research Design & Innovation Symposium

This study inquired about the potential association between insomnia and porn addiction across various sexual gender identities in Rhode Island Young Adults. Using data from the 2022 Rhode Island Young Adult Survey, 1,022 young adults aged 18-25 who live in Rhode Island—for at least a part of the year, were successfully recruited. Multivariable logistic regression was used to estimate the relationship between insomnia and porn addiction. An interaction term between sex/gender identity (cisgender heterosexual males; cisgender heterosexual females; sexual and gender minorities) and insomnia was added to the model to assess potential moderation.

Results from the study show that young …

Mindfulness Strategies For Older Adults, Jennifer Macnie

Student Research Design & Innovation Symposium

This literature review aimed to identify the current research related to mindfulness in addressing mental health concerns. Anxiety and depression are extremely prevalent amongst older adults living in Assisted Living Facilities (ALF) (Morgan et al, 2016; Wallis et al., 2018). Currently, anxiety and depression are mainly treated by pharmaceutical treatments and cognitive behavioral therapy, however an increase of non-pharmaceutical treatment methods are needed (Wallis et al., 2018). The development and evaluation of occupation-based mindfulness programs in ALF will help to identify best practices for addressing mental health concerns in this setting.

Mindfulness Interventions For Pediatric Cancer, Dara Studnitzer, Tori Sandull, Bella Fazio

Student Research Design & Innovation Symposium

Research on mindfulness-based interventions is limited but necessary to determine the potential impacts on quality of life among children diagnosed with cancer. The objective was to investigate the effectiveness of mindfulness-based interventions in improving quality of life outcomes for children diagnosed with cancer. Preferred Reporting Items for Systematic and Meta-Analysis (PRISMA) guidelines were used for the systematic review. Studies from 2014 to 2024 that focused on interventions such as mindfulness, meditation and yoga for children ages 6-12 with a cancer diagnosis were reviewed, and outcomes that include quality of life, life satisfaction, well-being, and happiness were analyzed. Six studies met …

Igd And Nmpdu: Associations By Student Status, Steve Jacob

Student Research Design & Innovation Symposium

The popularity of video games and prescription drug misuse throughout college campuses may promote co-occurring behavior. This cross-sectional study examined the association between internet gaming disorder (IGD), non-medical prescription drug use (NMPDU), and student status among young adults in Rhode Island. Data from N=1,022 Rhode Island young adults aged 18 to 25 (124 lifetime prescription drug misusers) was included in this study. Logistic regression models showed that with each additional unit in the gaming addiction scale (GAS), odds of NMPDU increased by 6% (OR[95%CI]=1.06 [1.02,1.10]), controlling for age, sexual and/or gender identity, race/ethnicity, and social status. The interaction between student …

Social Media And Depression In College Students, Jadyn Torres, Lilly Oliveira

Student Research Design & Innovation Symposium

While studies suggest social media use may increase the risk of poor mental health, few studies have examined how the ways in which college students use social media may play a role in this risk. A prospective cohort study (N=586) of college students who own iPhones at a higher education institution in the northeast US was conducted with five follow-up visits in October 2021 through March 2022. Social media uses were assessed using the Social Networking Sites Usage & Needs Scale, measuring five different domains: diversion, cognitive, affective, personal integration, and social integration. Time lagged, generalized estimating equations (GEE) models …

Ot For Acquired Physical Disabilities, Olivia Rousseau, Stephanie Tudela, Jacqueline Needle, Joanne Barnhart, Thuy Do

Student Research Design & Innovation Symposium

Sexuality is often overlooked in the rehabilitation process for adults with newly acquired physical disabilities, and adequate resources are not provided to clients experiencing difficulty with sexual function. This review explored research on the impacts of Occupation-Based Interventions (OBI) on the ability of adults with acquired physical disabilities to engage in sexual activities. Articles were assessed using PRISMA guidelines to review data quality, validity, and risk of bias. Six peer-reviewed articles were examined regarding occupation-based approaches in sexual rehabilitation for adults with spinal cord injuries, amputations, multiple sclerosis, and strokes. Data was analyzed to identify recurring themes and intervention outcomes. …

Medical Providers' Understanding Of The Role Of Ot, Zachery Edwards

Student Research Design & Innovation Symposium

The purpose of this scoping review was to gather information on medical providers’ current understanding of occupational therapy’s (OT) scope of practice and how their understanding impacts OT referrals. The question that guided this review was: does an increase of education on occupational therapies (OT) scope of practice for medical providers increase their understanding of OTs role? Current research highlights an inaccurate understanding of OT’s role by medical providers, which leads to decreased referrals. Further research is needed to determine medical providers’ motivation to receive education on OT’s scope of practice, what education methods are most beneficial, and if that …

Benefits Of Aquatic Therapy In Older Adults, Matile Kaplan

Student Research Design & Innovation Symposium

Aquatic Therapy (AT) helps with physical, mental, and psychosocial components of recovery. Substantial evidence shows that traditional (on-land) therapy has a positive impact on quality of life and occupational performance. However, limited research exists on the impact of combining traditional and aquatic therapies on rehabilitation outcomes and occupational engagement. Aquatic therapy has been a therapeutic modality since 2400 B.C. and is not fully exploited despite having strong evidence of its benefits (B.E. Kauffman & B.W. Kauffman, 2014; Chesapeake Bay Aquatic and Physical Therapy, 2024). There is a large gap in the literature about the benefits of combining aquatic and on-land …

Si & Processing On Student Occupational Engagement, Kyla Campbell

Student Research Design & Innovation Symposium

Sensory Integration (SI) is defined as the brain's ability to organize and respond to information within the body and environment. School-aged children begin school with varying difficulties in SI and processing, which affects their social and academic performances. The field of occupational therapy (OT) promotes engagement in meaningful activities, in which going to school and participating in activities is vital to a child's development and wellbeing. The school setting is the second-largest employer of occupational therapy practitioners (OTPs) in the United States. Children with SI and processing difficulties have decreased participation in the classroom compared to their peers with typical …

Disability, Mental Health & Substance Use In Sgms, Haylee Canadas

Student Research Design & Innovation Symposium

Sexual and gender minorities (SGMs) have higher rates of disability and chronic illness compared to the general population, and current literature suggests that both groups face higher rates of substance misuse and poor mental health outcomes. Despite this, little research has investigated the intersection of these identities. From February to March 2022, data was collected from 1,316 SGM adults living in the US. Multivariable logistic regression was used to analyze the relationship between disability status and mental health and substance misuse outcomes while controlling for demographics. After adjusting for covariates, SGMs with a disability had significantly increased odds of anxiety …

Insurance And Colorectal Cancer Outcomes, Cierra Bradford

Student Research Design & Innovation Symposium

Colorectal cancer (CRC) is one of the leading causes of cancer-related morbidity and mortality in the United States. Insurance status plays a pivotal role in CRC outcomes by influencing early detection, access to effective care, and overall survival. This review examined the current research on the relationship between insurance coverage and CRC outcomes between the years 2010-2021, highlighting health disparities and inequities. Findings reveal that those who are uninsured or underinsured face delayed diagnoses, limited access to treatment, and have poorer survival rates compared to those with comprehensive insurance coverage.

Medicaid Expansion And Black Maternal Mortality, Michaela Siver

Student Research Design & Innovation Symposium

Maternal mortality is a national health crisis, disproportionately affecting Black women. The Medicaid expansion program, an optional program at the state level, is responsible for providing coverage for nearly half of all live births in the United States. This research addressed if Medicaid expansion has reduced maternal mortality rates, especially for Black women, when compared to non-expansion states. Multiple literature searches yielded a set of peer-reviewed journal articles and government reports that were used to answer this question. Medicaid expansion has resulted in a significant decline in maternal deaths, with 7.01 fewer casualties per 100,000 births in expansion states as …

Lsvt Big Vs. Boxing: Community Engagement In Pd, Amber Brown, Grace Carolonza, Shannon Fogarty, Alexis Labelle

Student Research Design & Innovation Symposium

Parkinson’s disease (PD) is a chronic, progressive disease that can impair an individual’s ability to engage fully in community activities. This systematic review aimed to compare the effects of Lee Silverman Voice Treatment BIG (LSVT BIG) and non-contact boxing (NCB) on community engagement among individuals with PD. A comprehensive search was conducted across four academic databases—CINHAL, EBSCO Academic Complete, PubMed and the Cochrane Library. Adhering to PRISMA guidelines, this review assessed risk of bias and levels of evidence using established, industry-standard tools. Eligible studies were peer-reviewed, published between September 2019 and September 2024, focused on either LSVT BIG or NCB, …

Adaptive Skiing And Complex Communication Needs, Jordan Chizmadia

Student Research Design & Innovation Symposium

Participation in adaptive sports, those modified to meet the needs of individuals with disabilities, empower athletes by fostering self-determination, helping them recognize their potential, and build confidence (Hajjar et al., 2018; Labbé et al., 2019). Communication is a critical aspect of adaptive sports, enabling athletes to express their needs and understanding of the sport (Hajjar et al., 2016; Hajjar & McCarthy, 2022a). For individuals with complex communication needs (CCN), or those with barriers using natural speech for everyday communication; adaptive skiing can present unique challenges due to communication barriers. Occupational therapists can develop client-centered strategies to adapt communication, incorporating both …

Self-Directed Goals For Forensic Patients, Chapin Graham

Student Research Design & Innovation Symposium

Patients within a forensic setting experience occupational deprivation. This impacts their mental health outcomes, aggressive tendencies, and overall wellness. The purpose of this study was to explore how the setting and achieving of self-directed goals impact forensic patients’ occupational deprivation. The study was a single-group, pre- and post-test pilot study. Participants completed the Canadian Occupational Performance Measure (COPM) before and after a 10-week treatment period. Treatment included an educational group therapy session one time a week aimed at goal setting and a one-to-one session once per week aimed at setting goals and achieving them. Observation notes were completed after every …

Exposure To Gun Violence In Childhood, Lilly Oliveira

Student Research Design & Innovation Symposium

Gun violence is a growing public health crisis, with firearm-related fatalities rising to 62.5% from 2012 to 2022. Disparities exist with Black and Hispanic individuals, particularly with males and adolescents facing heightened risks. The 2024 Rhode Island Young Adult Survey recruited 1,008 young adults aged 18-25 years who lived in Rhode Island. Exposure to gun violence is disproportionately high among sexual and/or gender minorities (43.9%) and Hispanic youth (44.2%). Exposure to gun violence in childhood is associated with poor mental health outcomes and substance use disorders in adulthood. Those who were exposed to gun violence in childhood had higher odds …

Sensory Intervention For Bereaved Children, Eleanor Gemma

Student Research Design & Innovation Symposium

Bereaved children have unique sensory needs due to unregulated bodily experiences impacting one’s sensory modulation. There is a lack of evidence-based sensory strategies used with children receiving bereavement services in Rhode Island, and little understanding of how sensory strategies can impact client's regulation. The purpose of this scoping review was to explore the sensory interventions currently being applied with children who are experiencing bereavement.

Restrictive Masculinity And Depression, Abigail Nosal

Student Research Design & Innovation Symposium

Restrictive masculinity contains rigid traditional norms that reinforce emotional suppression, dominance, and self-reliance, contributing to poor mental health outcomes. The goal of this study was to determine if belief in restrictive masculinity norms was associated with depressive symptoms in young adults. A survey of n=1008 young adults (18-25 years old) living in Rhode Island was completed. Restrictive masculinity was measured using a 12-item questionnaire, and depressive symptoms were measured using the 10-item CES-D10. Logistic regression models, stratified by sexual/gender status, were used to estimate the main effects, after adjusting for age, race, ethnicity, and relative social status. Overall, 45.4% of …

Newport Health Equity Zone Development, Kaitlyn Grant

Student Research Design & Innovation Symposium

Newport, Rhode Island, the home of many affluent Rhode Islanders, is not immune to extreme health disparities that plague the rest of the state. The Ocean State’s records report that 15% of all Rhode Island children lived in poverty between 2020 and 2024, of which 76% were children of color. The report also found that 280 families with 559 children stayed in a homeless or emergency shelter last year. To address the unique needs of communities in Rhode Island, the Rhode Island Department of Health has established Health Equity Zones. The Health Equity Zone model is a public health initiative …