Medicine and Health Sciences Commons^™

The Role Of Advocacy And Occupational Justice In Increasing The Accessibility Of Parks For Parents With Disabilities, Nathan Burke-Tan

Doctoral Projects

The purpose of this doctoral capstone project was to address ongoing accessibility barriers experienced by adults with disabilities, particularly those in caregiving roles, in public parks and playgrounds in the greater San Diego region. Although many parks meet the minimum requirements of the Americans with Disabilities Act (1990), research shows that caregivers with disabilities continue to encounter obstacles that limit safe, meaningful participation in community spaces (Dalpra, 2022; Fernelius, 2017; Firkin et al., 2024; Movahed et al., 2023; Ogletree et al., 2020; Prellwitz & Skar, 2007). These persistent gaps indicate a need for stronger advocacy and clearer public awareness of …

Grounded In Experience: A Collaborative Approach To Resource Development For Adults With Ehlers-Danlos Syndrome, Morgan Kam

Doctoral Projects

Background: Ehlers-Danlos syndrome (EDS) is a complex connective tissue disorder that significantly affects daily occupations, participation, and quality of life, yet early support for individuals pursuing or newly receiving a diagnosis remains limited. Occupational therapy (OT) is uniquely positioned to address these challenges through interventions that promote self-management and functional engagement.

Purpose: This project aimed to develop an experience- and evidence-informed educational resource for individuals undergoing or newly receiving an EDS diagnosis, while increasing awareness of OT’s role in managing this chronic, multisystemic condition.

Methods: A mixed-methods approach integrated qualitative insights from interviews, online support groups, and practitioner feedback. A …

Family-Level Impacts Of Equine-Assisted Occupational Therapy For Children With Disabilities: An Exploratory Mixed-Methods Pilot Study, Emily Canigiula

Doctoral Projects

Equine-assisted occupational therapy (EAOT) has been shown to enhance functional, social, and quality-of-life outcomes for children with disabilities (McDaniel Peters & Wood, 2017; Prieto et al., 2022). While child-focused outcomes are well documented, significantly less is known about how EAOT participation may influence caregivers and the broader family unit, as existing research largely prioritizes individual outcomes over family experiences (Peters et al., 2017; Tan & Simmonds, 2018; Trzmiel et al., 2019; Xiao et al., 2023). Emerging qualitative studies suggest potential family-level impacts including family engagement, reduced parental stress, and enhanced feelings of pride, empowerment, and connection (Kalmback et al., 2020; …

Bridging Gaps With Occupational Therapy: The Unique Role Of Occupational Therapy In Women’S Day Shelters, Alex Sato

Doctoral Projects

Homelessness is a multifaceted, complex issue that we face as a society. Mainstream services provided to homeless or vulnerable populations tend to focus on housing and basic services. While these are essential and meaningful, literature suggests there is a lack in trauma and self-care support (Marzana et al., 2023; Milaney et al., 2020). Looking through an Occupational Therapy (OT) lens, there are a multitude of ways the profession can provide holistic care. Current OT service provision within this population most commonly focuses on obtaining and maintaining housing and addressing the survival occupations these individuals may be engaging in (Cunningham & …

Applying Occupational Empowerment Principles In A Life Skills Program For Unhoused Transitional-Aged Youth: Feasibility And Early Outcomes, Eriza Navarro

Doctoral Projects

The purpose of this occupational therapy doctoral capstone project was to address a gap in community-based services for unhoused transitional-aged youth (TAY) by promoting life skill acquisition and supporting participation in meaningful activities in order to enhance self-efficacy. This project aimed to design, implement, and evaluate a structured occupation-based life skills program that builds upon existing services at a local drop-in center. The program incorporated life skill education and activity-based, experiential interventions tailored to meet the needs and learning styles of the population. Methods included conducting a needs assessment, developing the program curriculum, and piloting the 6-week program consisting of …

Promoting Participation And Self-Efficacy Among Youth With Disabilities In Community-Based Vocational Education, Allison Hollender

Doctoral Projects

Occupational therapy, with its focus on participation, contextual adaptation, and strength-based practice, is uniquely suited to support the growth and inclusion of youth in transition (Angell et al., 2018; Cahill et al., 2020; Carroll et al., 2025). Research indicates that transitional-aged youth (TAY) with disabilities, ages 14-24, are less likely to graduate from high school, pursue postsecondary education, or live independently (BLS, 2024; Cheng & Shaewitz, 2022; Cook et al., 2015). These disparities are compounded by occupational deprivation, or limited opportunities for meaningful participation, which can negatively impact long-term self-efficacy and belonging (Arbesman & Logsdon, 2011; Cahill et al., 2020). …

From Silos To Synergies: How To Enhance Interdisciplinary Collaboration Among Graduate Students, Jennifer Jimenez

Doctoral Projects

Interprofessional education (IPE) is essential for preparing collaborative healthcare practitioners, yet opportunities at San José State University (SJSU) have been limited, inconsistent, and largely dependent on individual faculty initiative. This capstone project aimed to strengthen IPE at SJSU by assessing institutional capacity and developing feasible, sustainable strategies to enhance exposure and participation across health-related programs. Guided by the Person–Environment–Occupation–Performance (PEOP) model and adult learning theory, the project combined a needs assessment, literature review, and partnership with the Healthy Development Community Clinic (HDCC) to create an instructor implementation guide and student introductory modules for HDCC service-learning onboarding. An IRB-approved mixed-methods faculty …

A Guide To Falls In A Skilled Nursing Facility, Sarah Ghione

Doctoral Projects

Approximately one in four older adults experiences a fall each year in the United States (Centers for Disease Control and Prevention [CDC], 2024b; Kakara et al., 2023). Among those residing in nursing homes for either short-term rehabilitation or long-term care, the risk of falls is doubled (Acker & Janssen, 2017; Shao et al., 2023). The purpose of this doctoral capstone project was to develop an educational resource aimed at enhancing staff education and fall prevention efforts within a single nursing home, supporting the facility’s goal of reducing fall rates. Methods included a needs assessment, observational experiences, resource development, and the …

Identification Of Potential Prophylactic Medical Countermeasures Against Acute Radiation Syndrome (Ars), Kia T. Liermann-Wooldrik, Arpita Chatterjee, Elizabeth A. Kosmacek, Molly Myers, Oluwaseun Adebisi, Louise Monga-Wells, Liu Mei, Michelle P. Takacs, Patrick H. Dussault, Daniel R. Draney, Robert Powers, James W. Checco, Chittibabu Guda, Tomáš Helikar, David B. Berkowitz, Kenneth W. Bayles, Alan H. Epstein, Lynnette Cary, Daryl J. Murry, Rebecca E. Oberley-Deegan

Journal Articles: Pathology and Microbiology

Acute radiation syndrome (ARS) occurs when hematopoietic or gastrointestinal cells are damaged by radiation exposure causing DNA damage to the bone marrow and gastrointestinal epithelial stem cell populations. In these highly proliferative cell types, DNA damage inhibits stem cell repopulation. In humans and animals, this inability to regenerate stem cells is lethal. Within this manuscript, several compounds, Amifostine, Captopril, Ciprofloxacin, PrC-210, 5-AED (5-androstene-3β,17β-diol), and 5-AET (5-androstene-3β,7β,17B-triol), are assessed for their ability to protect against ARS in an in vitro and/or in vivo setting. ARS was accomplished by irradiating mouse bone marrow cells or rat intestinal epithelial (IEC-6) cells in vitro …

Aneurysmal Dilatation Following Common Femoral Artery Directional Atherectomy, Timothy H.H. Kam, Bryan P. Yan, Guangming Tan

Journal of the Hong Kong College of Cardiology

Aneurysmal dilatation is an uncommon but serious complication of directional atherectomy for heavily calcified lower extremity arterial disease. In the absence of established treatment guidelines, this case report describes the successful endovascular management of a common femoral artery aneurysm following directional atherectomy using covered stents.

Iatrogenic Femoral Arteriovenous Fistula After Leadless Pacemaker Implantation Treated With Balloon-Expandable Stent: A Report Of Three Cases, Cheuk Yin Lai, Timothy Ho Him, Mark Tk Tam, Guang-Ming Tan, Bryan P Yan

Journal of the Hong Kong College of Cardiology

Endovascular covered stenting is a minimally invasive option for treating iatrogenic femoral access site complications, including arteriovenous femoral fistula (AVF). Reports on AVF repair mainly concern small bore devices, but large bore devices such as leadless pacemakers post unique challenges. We present 3 cases of iatrogenic femoral AVF after large-bore, 27Fr access sheath insertion for leadless pacemaker implantation. Both underwent endovascular balloon-expandable covered stenting, with resolution of AVF and durable long-term results. As patients referred for leadless pacemaker implantations are often frail with co-morbidities, endovascular stenting is an appealing alternative to open surgical repair for AVF.

Examining Differences In Rural And Urban Medicare Ffs Beneficiaries’ Emergency Department Use Before And During Covid-19, Alana Knudson, Craig D. Holden, Marilyn Klug, Tricia Stauffer, Shena Popat

ETSU/NORC Rural Health Research Center Policy Briefs

No abstract provided.

Effects Of Round-Up On The Environment, Sandra J. Marcu

Journal of Earth and Life Science

Many people around the world have used and still currently use Roundup but are unaware of the effects it has on the environment. Roundup is a spray on application weedkiller that is widely used around the world today both residentially and commercially. It enables its user to grow a garden or a field of crops with a no-tilling approach to eliminate weeds. It is a well-known and popular choice for killing weeds that has been around since the mid 1970’s (Oca, 2017). John Franz, a Monsanto scientist discovered that glyphosate (main ingredient in Roundup) was an herbicide or weedkiller, and …

Back Matter, Arianna Medina

Western Journal of Orthopaedics

No abstract provided.

A Brief History Of Opioid-Use Disorder In The United States, Effect On Orthopaedics, And Current Management Options, William Curtis, Nicholas Newcomb, Eric S. Kruger, Christopher L. Shultz

Western Journal of Orthopaedics

Declared a public health emergency in 2017 and leading to 11 million years of life lost worldwide, the American opioid crisis has impacted millions of people, with up to 7 million experiencing opioid use disorder. In orthopaedic surgery, opioid analgesia has been associated with various complications, including infections, deep vein thrombosis, prolonged hospital stays, and overall inferior outcomes after surgical procedures. Orthopaedic surgeons commonly rely on opioids to provide postoperative analgesia and may frequently encounter patients with opioid use disorder. It is therefore essential that orthopaedic surgeons understand opioid use disorder, its effect on orthopaedic outcomes, and management of opioid …

Scar Tissue Adhesions, Neuromuscular Guarding, And Functional Recovery: A Case Report Of Physical Therapy Post-Cholecystectomy, Raeisa Griñe, Adam Walsh

Western Journal of Orthopaedics

Scar tissue from abdominal surgeries, such as cholecystectomy, can lead to long-term issues such as restricted movement, painful spasms, and impaired function. Laparoscopic adhesiolysis is a common surgical treatment for pathological scar tissue impairments. Conservative care, such as physical therapy, is a commonly used approach for managing pathological scar tissue. In this case, manual therapy techniques and targeted exercises successfully reduced the intensity and frequency of abdominal spasms, improved core strength and endurance, and enhanced overall functional mobility. These improvements were reflected in enhanced scores on the Lower Extremity Functional Scale and the Vancouver Scar Scale in a 59-year-old woman …

Treatment Sequence With Tebentafusp And Immune Checkpoint Inhibitors In Patients With Metastatic Uveal Melanoma And Metastatic Gna11/Gnaq Mutant Melanocytic Tumors, Florentia Dimitriou, Marlana Orloff, Erica Koch Hein, Phil Cheng, Isaac Hughes, Ester Simeone, Kamaneh Montazeri, Piyush Grover, Inderjit Mehmi, Camille Gerard, Caroline Gaudy-Marqueste, Jean-Jacques Grob, Olivier Michielin, Omid Hamid, Georgina Long, Ryan Sullivan, Ellen Kapiteijn, Douglas Johnson, Paolo Ascierto, Anthony Joshua, Richard Carvajal, Marcus Butler, Jessica Hassel, Reinhard Dummer

Kimmel Cancer Center Faculty Papers

BACKGROUND: Metastatic uveal melanoma (mUM) is rare. Immune checkpoint inhibitors (ICIs) have shown modest efficacy in mUM. Tebentafusp prolonged overall survival (OS) in a phase 3 study. We aimed to investigate the efficacy and safety of the sequence of tebentafusp and ICIs.

METHODS: Patients with HLA-A * 02:01 positive mUM, or metastatic GNA11/GNAQ mutant melanocytic tumors treated with tebentafusp followed by ICIs (group 1) or the inverse sequence (group 2) at any treatment line were retrospectively identified. The primary objective was OS rate at 2 years.

RESULTS: 131 patients were included; 51 in group 1 and 80 in group 2. …

Effects Of Liraglutide On The Gut Bacterial Community, Jami Anne Bull

Graduate Theses/Dissertations

Overweight and obesity are major health concerns associated with metabolic disorders and gut dysbiosis. Treatment options such as GLP-1 receptor agonists, like liraglutide, promote weight loss and improve insulin sensitivity; however, their impact on the gut bacterial community remains unclear. This study investigated the effects of liraglutide on the gut bacterial community of diet-induced obese (DIO) mice using Illumina DNA sequencing of the bacterial 16S rRNA gene. My study used twelve-week-old male C57BL/6J DIO mice. They were placed on a high-fat diet and treated with liraglutide (0.2 mg/kg) via daily subcutaneous injection for 14 Days. High-fat and low-fat diets control …

Preventing Chemical And Biological Attacks: Enhanced Threats Requiring Enhanced Solutions, Alex Elliot Ottoni-Belval

Graduate Theses/Dissertations

Chemical weapons (CW) and biological weapons (BW) are becoming more dangerous for experts to employ and more accessible to amateurs. Despite CW and BW attacks throughout history that killed and maimed millions of people, the international community has failed to establish meaningful consequences to prevent them. Agreements such as the Chemical Weapons Convention and the Biological Weapons Convention vow to eliminate and reduce the effects of CWs and BWs but lack respected response precedents and capabilities. The limited and inconsistent enforcement has inadvertently allowed CWs and BWs to become plausible weapons, especially to gain asymmetric advantages, while modern developments exasperate …

Alpha-Synuclein Interaction With Gedunin, Tony Matundura Nyabayo

Graduate Theses/Dissertations

Parkinson’s disease (PD) and other Proteinopathies develop when α-synuclein misfolds and aggregates into toxic amyloids. While existing treatments for PD are primarily focused on managing its symptoms, a viable solution for slowing down the progress of Parkinson’s disease involves targeting the toxic α-synuclein amyloids. Gedunin, a natural inhibitor of heat shock protein 90, has been extensively used to treat malaria. Also, recent research investigations have shed light on its potential beyond malaria therapy, indicating that Gedunin may offer a possible solution for treating a variety of neurodegenerative diseases. Using plate-based assays, we examined how Gedunin influences α-synuclein fibrillation and its …

An Investigation Of The Physiological And Behavioral Correlates Of Mental Imagery, Matthew Daniel Carroll

Graduate Theses/Dissertations

Many conventional theories hold mental imagery to be fundamental to self-regulation. Recently, a current of research into mental imagery has developed, with the terms anaurelia and aphantasia being coined for the inability to experience, respectively, auditory and visual thought content, yet little is known about the impact that such individual differences have on persons’ lives. The present experiment was performed in order to test the hypotheses that self-regulation and mental imagery positively correlate and that mental imagery mediates the correlation of resting heart-rate variability and self-regulation. Self-regulation was measured via a self-report questionnaire (the Short Self-Regulation Questionnaire), as was mental …

Characterizing A Rad23 Dependent Ultraviolet Radiation Resistance In Tetrahymena Thermophila, Emma June Liimatta

Graduate Theses/Dissertations

In 2020, 10 million deaths were attributed to cancer, with multidrug resistance being responsible for over 90% of deaths in cancer patients receiving treatment. This study utilized the model organism Tetrahymena thermophila to study how cells become resistant to Ultraviolet Radiation (UV) radiation, a process similar to multidrug resistance, specifically focusing on the nucleotide excision repair and ubiquitin shuttle protein Rad23. The National Cancer Institute documented 30-60% of cancers tested had a mutation in RAD23. Knockdown of RAD23 in Tetrahymena thermophila demonstrated a UV resistance phenotype with decreased nucleotide excision repair and differential expression of proteins active within caspase-independent …

A Retrieval Augmented Approach To Improving Accuracy Of Biomedical Term Normalization By Large Language Models, Thanh Son Do

Graduate Theses/Dissertations

Ontology normalization is crucial in biomedical text processing, as it enables the mapping of medical expressions to standardized ontology terms and their corresponding identifiers. This thesis explores the feasibility of using large language models (LLMs) for ontology normalization, with a specific focus on the Human Phenotype Ontology and Gene Ontology. Prior research studies indicated that LLMs employing zero-shot learning tend to exhibit low accuracy and are prone to frequent hallucinations. We propose a retrieval augmented generation (RAG) approach to address these limitations and enhance normalization accuracy. We generated synthetic test sets of ontology-derived synonyms to evaluate normalization performance and developed …

Effects Of Active Learning In An Undergraduate Physiology Class Using Hands-On And Simulation Labs, Ainsley C. Frayer

Graduate Theses/Dissertations

Increasing student engagement has shown positive effects on students and can be achieved by incorporating active learning strategies in the lab. Currently, the undergraduate human physiology lab at Missouri State University utilizes simulations to practice physiological concepts. The proposed project aims to evaluate if incorporating hands-on labs would improve student learning and/or their engagement. The hypothesis is engagement will be increased in hands-on labs, but grades will not differ significantly, based on previous literature. Three simulations were replaced with hands-on lab software to evaluate engagement and learning. Student engagement was assessed using a voluntary, anonymous survey. Exam average scores were …

The Role Of Host Factor Sptbn1 In Hiv-1 Capsid Uncoating In Human Microglial Cells, Callie Marie Fry

Graduate Theses/Dissertations

HIV-1 is the virus that causes acquired immunodeficiency syndrome (AIDS), and currently, there is no cure once an individual is infected. The development of new drugs targeting HIV-1 replication steps is essential for keeping viral loads low or undetectable to prevent further transmission. An attractive replication step for new drug targets is viral capsid uncoating, where the virus loses the protein structure encapsulating the genome. The exact mechanism of capsid uncoating is unknown; however, several host-factors may be involved including protein SPTBN1. Recent studies have shown a significant decrease in viral infectivity when SPTBN1 is knocked down, yet its role …

Psychological Techniques For Athletes With Orthopedic Musculoskeletal Injuries: A Systematic Review, Nicole L. Williams

Antioch University Dissertations & Theses

Musculoskeletal injuries and recovery from them play a vital role in both the physical and psychological wellbeing of the public. Existing research has been conducted primarily within the athlete population with rehabilitation from these injuries having a profound impact on the physical and mental health. One of the most frequent psychological responses related to sports injuries is a trauma response, which has been shown to hinder the rehabilitation process and to increase the likelihood for reinjury upon return to play. Embedded within the many inputs to trauma responses to these injuries are psychological distress reactions, in particular fear connected to …

Nsu Health Professions Division 2024-2025 Course Catalog, Nova Southeastern University

HPD Course Catalogs

• Dr. Kiran C. Patel College of Osteopathic Medicine
• Barry and Judy Silverman College of Pharmacy
• College of Optometry
• Dr. Pallavi Patel College of Health Care Sciences
• College of Dental Medicine
• Ron and Kathy Assaf College of Nursing
• Dr. Kiran C. Patel College of Allopathic Medicine

Comparing Approaches To Estimating Person Parameters For The Mupp Model, David M. Lahuis, Caitlin E. Blackmore, Gage M. Ammons

Psychology Faculty Publications

This study compared maximum a posteriori (MAP), expected a posteriori (EAP), and Markov Chain Monte Carlo (MCMC) approaches to computing person scores from the Multi-Unidimensional Pairwise Preference Model. The MCMC approach used the No-U-Turn sampling (NUTS). Results suggested the EAP with fully crossed quadrature and the NUTS outperformed the others when there were fewer dimensions. In addition, the NUTS produced the most accurate estimates in larger dimension conditions. The number of items per dimension had the largest effect on person parameter recovery.

Understanding The Impact Of The Care Connect Washington Program, Hannah Cohen-Cline, Dan Fish, Taylor Doren, Abby Bush

Articles, Abstracts, and Reports

No abstract provided.

At The Crossroads: Initial Findings And Lessons Learned From A Medicaid Housing Benefit Pilot, Cat Livingston, Megan Holtorf, Benjamin Gronowski, Alyssa Cragie

Articles, Abstracts, and Reports

No abstract provided.