Medicine and Health Sciences Commons^™

Emerging Role Of Liafensine In The Treatment Of Treatment Resistant Depression: Insights From The Enlighten Trial, Karla Narvaez, Saad Masud, Richard Callahan

East Florida Division GME Research Day 2025

Background: Treatment-resistant depression (TRD) remains a significant unmet need, affecting about one third of patients with major depressive disorder who fail to respond to two or more antidepressant trials. There is a need for new pharmacological approaches. Liafensine (also known as DB104) is a first-in-class triple reuptake inhibitor targeting serotonin, norepinephrine, and dopamine transporters, whose development has recently incorporated a precision medicine approach. Mechanism of Action: Liafensine inhibits reuptake of all three major monoamines (serotonin, norepinephrine, and dopamine) distinguishing it from existing SSRIs, SNRIs, or other agents which typically target one or two systems. A genetic biomarker, ANK3 (also called …

National Outcomes Of Pre-Emptive Tips In Patients With Acute-On-Chronic Liver Failure And Variceal Bleeding, Aya Akhras, Waseem Wahood, Azizullah Beran, Bisher Sawaf, Asad Ur Rahman, David Goldberg, Muhammed U. Shahid

East Florida Division GME Research Day 2025

Background

Pre-emptive transjugular intrahepatic portosystemic shunt (pTIPS), defined as placement within 72 hours of initial endoscopic therapy for an active variceal bleed, has been proposed as a strategy to reduce rebleeding and improve survival in high-risk patients with cirrhosis. We evaluated outcomes of patients with acute-on-chronic liver failure (ACLF) who presented with variceal bleeding and underwent therapeutic endoscopy (EGD) with or without the addition of pre-emptive TIPS.

Methods

The Nationwide Readmissions Database (2010–2022) was queried for patients with ACLF using previously validated algorithms admitted with variceal upper GI bleeding who received endoscopic intervention. Patients were stratified into two groups: therapeutic …

The Role Of Bandemia In Clinical Outcomes Of Critically Ill Septic Patients., Yerandi Gil, Grettel Gonzalez Garcia, Ambar Sekulis, Rafael Miret, Siddarth Kathuria, Mauricio Danckers, Daniel Heller

East Florida Division GME Research Day 2025

Rationale: Bandemia, defined as the presence of immature neutrophils in circulation, is commonly used as an early marker of systemic inflammation and infection. 1 However, its prognostic significance in sepsis, severe sepsis, and septic shock remains uncertain. 1-2 This study aimed to determine whether bandemia is associated with adverse clinical outcomes and increased intensive care unit (ICU) resource utilization among critically ill septic patients admitted from the emergency department (ED).

Methods: A retrospective analysis was conducted using de-identified data from the HCA Healthcare database. Adult patients (aged 18–90 years) admitted to the ICU at HCA Florida Aventura Hospital from the …

Laproscopic Robotic-Assisted Common Bile Duct Exploration For Primary Choledochlithiasis 20 Years After Cholecystetomy In A Hostile Abdomen, Enoch Wong, Kristen Payne, James Burdick, Hassan Ahmed

North Texas Research Forum 2025

Introduction: The incidence of concomitant cholelithiasis and choledocholithiasis is 5-20%. Primary choledochlithiasis more than 3 years after cholecystectomy is an even rarer event with only a handful of case reports in the literature. Robot-assisted laparoscopic common bile duct exploration with intraoperative choledochoscopy is a relatively recent development in biliary surgery. In this report, we describe the use of this technique in a patient with rare presentation and surgically challenging anatomy. Objective: To describe a minimally invasive approach for CBD exploration with extraction of choledocholithiasis in a surgically hostile abdomen and Roux-En-Y anatomy. Methods: This report describes the case of a …

An Unexpected Source Of Gi Bleeding: Enteric Muco-Submucosal Elongated Polyp In The Proximal Jejunum With Literature Review, Galvin Dhaliwal, Dev Patel, Ashvin Singh Dhaliwal, Aakriti Soni, Bilal Ashraf, Shane Sweeney, Sushovan Guha, Ahmed Ouni

Gulf Coast Division GME Research Day 2025

No abstract provided.

Turmeric, Red Yeast Paste, And Statins: A Recipe For Dili, John V. Nahas, Sinay Ceballos, Franklin Kasmin

East Florida Division GME Research Day 2025

Introduction Drug induced liver injury (DILI) contributes to a significant portion of acute liver injuries and acute liver failure in the west. DILI accounts for approximately 11% of acute liver failure cases in the US according to ACG. Insulting agents are numerous and well documented in the NIH LiverTox database, however the rarity and complexity of individual agents is a matter of ongoing study. Case Description/Methods A 52 year old man with PMH of HTN and HLD presents for a 2 week history of abdominal swelling, bilateral lower extremity swelling, decreased appetite, and positional shortness of breath. He endorses occasionally …

Development And Clinical Validation Of The Sensor-E Exoskeleton For Objective Hand Function Assessment In Stroke Rehabilitation, Madison Bates

Theses and Dissertations--Biomedical Engineering

Hand function is often impaired following neurological trauma or in conditions such as stroke, limiting independence and the ability to perform activities of daily living (ADLs). Current clinical assessments rely heavily on subjective rating scales that lack the resolution to detect subtle changes in motor performance, which can limit access to rehabilitation. Recent advances in wearable technologies highlight the potential for hand-worn devices to provide objective, real-time measures of hand function. However, most systems focus solely on kinematics and rarely capture both movement and exerted force. Moreover, integration into rehabilitation frameworks and brain-computer interface (BCI) protocols remains limited. To address …

The Process And Significance Of Convening A Community Advisory Board With Individuals With Severe Mental Illness, Jacelyn Biondo, Nia Johnson

Department of Medicine Faculty Papers

Individuals with lived experience of being diagnosed with severe mental illness and/or substance use disorders have deep and profound knowledge regarding the culture and needs of their community. Historically, these and other vulnerable populations have been excluded from care access, treatment insights, research development and participation, and often society in general. In this paper, we share our experience of convening a community advisory board with vulnerable populations and highlight the expertise these community members provide. We outline our processes of convening the community advisory board, engaging in collaborative meetings, revising the research protocol, and exploring future research needs. Using meeting …

An Evaluation Of The Decline In Primary Care Physician Visits, 2010 To 2021, Anuradha Jetty, Marie Ezran, Alison Huffstetler, Yalda Jabbarpour

Department of Family & Community Medicine Faculty Papers

INTRODUCTION: Primary care is the backbone of the United States healthcare system, yet it continues to be underfunded and inaccessible to many. Previous studies explored primary care visit patterns until 2016, leaving gaps in our understanding of how recent factors like state Medicaid expansions, the Coronavirus Disease 2019 (COVID-19) pandemic, and population growth have influenced these patterns. Hence, the objective of the current study was to analyze the trends in primary care visits provided by outpatient clinicians over time and by visit type and contextualize study findings within the changing healthcare landscape.

METHODS: The Medical Expenditure Panel Survey data (2010-2021) …

The Role Of Music In Public Health, Joy Allen Phd, Mt-Bc

All MHI Citations

Music is emerging as a critical yet underutilized determinant of public health. Evidence demonstrates that music-based interventions reduce hospital stays, medication use, and staff burnout while improving patient outcomes, caregiver well-being, and population-level health indicators. Despite these proven benefits, the field remains fragmented and underfunded, limiting its capacity to scale. This paper reframes music as a pillar of public health and argues for systems-level investment in infrastructure, workforce development, and cross-sector innovation. Drawing on the work of the Berklee Music and Health Institute, we highlight how translational research, accessible evidence tools, and interdisciplinary training are advancing equity-driven, sustainable approaches to …

Compelled Contraception, Lars Noah

UF Law Faculty Publications

Can the federal government insist that people use contraceptives? It may come as a surprise to learn that the U.S. Food and Drug Administration (FDA) has done just that as a condition for allowing access to some pharmaceutical products that create a serious risk of birth defects. Over the last few decades, the agency has demanded that patients using certain teratogenic agents—now numbering over a dozen drugs prescribed for a variety of conditions, ranging from severe acne and psoriasis to multiple myeloma and pulmonary hypertension—agree to avoid becoming pregnant, sometimes for years after completing their course of treatment. Undoubtedly the …

Medication Abortion And The Mails: The Ghost Of Anthony Comstock Rides Again?, Lars Noah

UF Law Faculty Publications

Mail-order dispensing of the prescription drug mifepristone has become the latest flashpoint in this country’s long-running debate over abortion access. It also has brought back from the dead one of the oldest federal statutes to address that contentious subject. In their fight to limit access to a drug approved by the FDA one quarter of a century ago, abortion opponents have rediscovered the Comstock Act. Although amended on several occasions since 1873, Congress never managed to repeal or clarify its ambiguous language relating to abortion. On its narrowest reading, this provision would have no impact whatsoever on access to mifepristone; …

Temporal Network Analysis Of Comorbidities Among People With Hiv In South Carolina, Yunqing Ma, Matthew Lohman Ph.D., Monique J. Brown Ph.D., Mph, Yichen Li, Xiaoming Li Ph.D., Bankole Olatosi Ph.D., Jiajia Zhang Ph.D.

Faculty Publications

Introduction: People with HIV experience a high rate of comorbidities that can complicate their health outcomes. Understanding the prevalence, interrelationships and temporal development of these comorbidities is crucial for improving health management and quality of life for people with HIV. Methods: We used a population-based cohort extracted from statewide electronic health record (EHR) data in South Carolina (SC), including 18 649 people with HIV who survived at least 1 year after HIV diagnosis between January 1, 2005, and December 31, 2020. Comorbidities and organ systems were classified using ICD-10 codes. Network analysis was performed to assess the closeness centrality among …

The Bonding Project: Addressing Mental Health Issues In The Older Lgbtq+ Community In Sacramento, Jose A. Gonzalez-Villasenor, Morgan Taniguchi, Claire Tousley, Jessica Landmark, Jacqueline Paine

ELMSN E-Portfolio. A collection of Scholarly and Creative Works

No abstract provided.

Navigating Burnout In Caregivers Of Patients With Alzheimer’S Disease, Kristie Tsao, Avenal Nair, Elijah Saavedra

ELMSN E-Portfolio. A collection of Scholarly and Creative Works

No abstract provided.

Supporting The Development Of Emotion Regulation For Engagement In Occupation, Alexis Karen Smith

Occupational Therapy Capstones

Purpose: Many children with mental, behavioral, and neurodevelopmental health conditions internalize and externalize symptoms of anxiety, depression, and anger at higher rates compared to children without these conditions (Tajik-Parvinchi, 2021). Difficulties with emotion regulation may lead to heightened experiences of symptoms from mental, behavioral, and neurodevelopmental health conditions (Tajik-Parvinchi, 2021). Occupational therapy practitioners can support children with emotional dysregulation by using evidence-based best practices. The identified problem is the application of evidence-based emotion regulation evaluation and interventions to support children with difficulty in emotion regulation and their caregivers. The challenge of implementing evidence-based emotion regulation services is limited research and …

Benefits Of Nature-Based Play For Children: An Educational Resource For Parents, Kaitlyn Peterson

Occupational Therapy Capstones

Background: In recent years, children’s use of technology has increased, decreasing the time they spend playing in natural contexts and time spent building the parent-child relationship. The lack of time spent in outdoor contexts has negative influences on the child’s overall health and well-being. The time a child spends with their parent is vitally important for a child’s development, view of the world, and sense of belonging. Parents assist children throughout development by supporting their understanding of themselves and the world, along with supporting the child’s ability to communicate with their parents. Interactions with technology, particularly overuse, can influence a …

Increasing Occupational Therapy Student Preparedness For Level Ii Fieldwork Experiences In Hand Therapy, Claire Meyer

Occupational Therapy Capstones

Background: A level II fieldwork experience is essential within occupational therapy programs as it allows occupational therapy students to apply what they have learned in the classroom to real-life practice. Students need to complete level II fieldwork to graduate, become practicing therapists, and grow the field of occupational therapy. However, many practitioners, particularly those specializing in hand therapy, hesitate to accept students for fieldwork placements. Barriers reported by hand therapy practitioners include a lack of student knowledge, preparation, and clinical skills (Short et al., 2017; Valdes et al., 2022). Hand therapy settings' rapid pace and demanding nature require students to …

Occupational Therapy Best Practices In Partial Hospitalization Programs, Mattea June Johnson

Occupational Therapy Capstones

Introduction: Occupational therapy practitioners play a crucial role on the care team in partial hospitalization programs (PHP). Occupational therapy practitioners are a key member of the care team due to their profession’s unique view of the person and goal of supporting them in their valued occupations. Occupational therapy practitioners have training in psychosocial and mental health interventions that enable those with mental illness to engage in meaningful everyday activities. Practitioners must be equipped with the current best practice standards to support participants to engage in recovery and wellness through occupation. With the growing need for mental and behavioral services and …

Specialized Knowledge Of Sensory Interventions For Sensory Function, Cassidy Kay Filson

Occupational Therapy Capstones

Purpose: Between 5%-16.5% of the general population are estimated to have a form of atypical sensory reactivity (Ahn et al., 2004). Atypical sensory reactivity or atypical sensory processing is described as when the brain processes sensory input differently than it typically would (Ark Support Coordination, n.d.). The rates of atypical sensory reactivity increase in children with additional diagnoses such as autism (ASD), developmental delays and disabilities, and neurodivergent children (AOTA, 2023). Sensory processing and integration difficulties negatively impact the quality and quantity of a child’s occupational participation, as symptoms often make various occupations more difficult for the child to participate …

The Impacts Of Ssris In-Utero And Nicu Occupational Therapy Intervention, Kyara Crowley

Occupational Therapy Capstones

Purpose: The purpose of this product was to collaborate with the occupational therapy (OT) staff in a neonatal intensive care unit (NICU) to further knowledge and enhance role competence to provide better quality of care to the selective serotonin reuptake inhibitor (SSRI) exposed infant population. Mental health conditions are becoming more prevalent among women, therefore, more women are taking SSRIs throughout pregnancy to counteract the effects of those conditions (Cleveland Clinic, 2024). However, the effects of in-utero SSRI exposure are not fully understood. Researchers have found evidence of some short-term and long-term effects caused by the SSRI exposure as well …

Unlock Upper Extremity Rehabilitation: Interprofessional Collaboration Between Ot Hand Therapy And Surgical Teams, Collin Brown

Occupational Therapy Capstones

Background: In the journey to recovery from upper extremity injuries, outpatient hand therapists who are certified as occupational therapists (OT) play a crucial role in restoring patients' independence and functionality, both before and after surgical intervention. Researchers identified main themes experienced by participants who had acquired an upper extremity injury and were post-operation, such as functional challenges in managing conditions, difficulties in everyday life, coping strategies, differing expectations, and the impact of information on daily life (Hansen et al, 2024). In all of these areas identified, an OT hand therapist is able to identify and facilitate improvements pre- and post-surgery …

Availability And Use Of Digital Technology Among Women With Polycystic Ovary Syndrome: Scoping Review, Pamela J. Wright Phd, Ms, Med, Rn, Cen, Charlotte Burts, Carolyn Harmon, Cynthia F. Corbett Phd, Rn, Faan

Publications

Background: Polycystic ovary syndrome (PCOS) is a common endocrinopathy among women that requires self-management to improve mental and physical health outcomes and reduce risk of comorbidity. Digital technology has rapidly emerged as a valuable self-management tool for people with chronic health conditions. However, little is known about the digital technology available for and used by women with PCOS. Objective: The purpose of this scoping review was to identify what is known about digital technology currently available and used by women with PCOS for PCOS-specific knowledge, self-management, or social support. Methods: The databases PubMed, Embase, CINAHL, and Compendex were searched using …

Materal Care In Focus: Non Birthing Facility Administrative Report, Juliana Antwi, Andrew Williams

Public Health Faculty Publications

A snapshot of facility types, staffing, and service gaps across North and South Dakota-this survey reveals key challenges and opportunities to strengthen maternal healthcare through the work of the NDPQC.

Readiness To The Privatization Of The Health System In Saudi Arabia: Translation And Factor Analysis Of Readiness To Organizational Change (Roc) Scale, Ahmed Ali Alasiri, Qi Zhang

Epidemiology, Biostatistics, & Environmental Health Faculty Publications

Background

The Kingdom of Saudi Arabia (KSA) began a major transformation as a part of version 2030 for its health system. These reform initiatives aim to privatize health services and improve efficiency. Despite this meaningful change, there is a knowledge gap in how healthcare providers prepare for or perceive this shift. Specifically, there has been a lack of validation of Arabic instruments that gauge the individual readiness to this change. This study bridges the gap by localizing and validating the Readiness to Organizational Change scale (ROC) to provide empirical evidence and to understand adaptability for the KSA context.

Method

The …

The Chemical Straightjacket: Institutional Over-Use Of Psychotropic Drugs On Children In Lieu Of Therapeutic Community Mental Health Services, Marisa Leib-Neri

Indiana Journal of Law and Social Equality

This Article argues that the abysmal state of children’s mental health in America is in part due to an overreliance on and over prescription of psychotropic drugs inside psychiatric residential institutions in lieu of community based mental health services. This overreliance on residential institutions and psychotropic drugs has allowed a new form of chemical restraint to flourish—the chemical straitjacket. This Article uses the medication lists of twelve children in seven different North Carolina psychiatric residential treatment facilities to demonstrate how the chemical straitjacket operates: the prescription of drugs not approved for pediatric populations, counter to evidence-based practices for particular diagnoses, …

A Comprehensive Review And Bibliometric Analysis On Collaborative Robotics For Industry: Safety Emerging As A Core Focus, Aida Haghighi, Morteza Cheraghi, Jérôme Pocachard, Valérie Botta-Genoulaz, Sabrina Jocelyn, Hamidreza Pourzarei

Revues de littérature, synthèses de connaissances

Research organizations and academics often seek to map the development of scientific fields, identify research gaps, and guide the direction of future research. In cobot-related research, the scientific literature consulted does not propose any comprehensive research agenda. Moreover, cobots, industrial robots inherently designed to collaborate with humans, bring with them emerging issues. To solve them, interdisciplinary research is often essential (e.g., combination of engineering, ergonomics and biomechanics expertise to handle safety challenges). This paper proposes an exhaustive study that employs a scoping review and bibliometric analysis to provide a structured macro perspective on the developments, key topics, and trends in …

Adenomatoid Tumor Of The Testis: A Report Of Two Cases And Literature Review, Amadadin Alhlib, Trudea Juma, Shahin Sayed

General Surgery, East Africa

Testicular adenomatoid tumor is a rare benign condition that can resemble testicular malignancies in its clinical presentation, potentially leading to overtreatment, such as radical orchidectomy. In our two case reports, we aim to better understand the behavior of this disease by examining its clinical presentation, as well as radiological, intraoperative, and pathological findings.

Ministry Organization Response To The Mental Health Crisis, Bryn L. Wood

Senior Honors Theses

The mental health crisis has been negatively affecting individuals across the globe for about half a century, only growing in its impact each year. However, following the Covid-19 pandemic, mental health crises skyrocketed. This is especially true for youth and young adults as physical isolation has altered many facets of their lives. This thesis will explore the mental health crisis, as well as the way it has impacted youth and young adult organizations. Specifically, it will discuss research on recommended ways for these organizations to respond to the mental health crisis through unique programming and how these practices have been …

The Association Between Obstetric Violence And Postpartum Depression Among Latina Women In The United States: An Integrative Review, Natalia Alameda

Scripps Senior Theses

Obstetric violence, a structural form of gender-based violence, involves abuse, mistreatment, or neglect by healthcare providers during obstetric care. It is often associated with childbirth trauma and may result in physical and psychological harm to mothers and children, including postpartum depression. Postpartum depression is a major depressive episode occurring during pregnancy or within four weeks following delivery. While these concepts are often studied independently, few studies examine their intersection, particularly among Latina women in the United States. To address this gap, an integrative literature review was conducted to explore the association between obstetric violence and postpartum depression among Latina women. …