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Articles 19171 - 19200 of 24580
Full-Text Articles in Medicine and Health Sciences
Federally Qualified Health Center Patients’ Experiences With Remote Patient Monitoring As Part Of Telehealth Services For Self-Measured Blood Pressure Monitoring, Natalia I Heredia, Maria E Fernandez, Ella R Garza, Jabria Pittman, Fernanda Velasco-Huerta, Tracy L Judd, Jocelyn Hunyadi, Elvis Longanga Diese, Deevakar Rogith, William B Perkison, Susan H Fenton
Federally Qualified Health Center Patients’ Experiences With Remote Patient Monitoring As Part Of Telehealth Services For Self-Measured Blood Pressure Monitoring, Natalia I Heredia, Maria E Fernandez, Ella R Garza, Jabria Pittman, Fernanda Velasco-Huerta, Tracy L Judd, Jocelyn Hunyadi, Elvis Longanga Diese, Deevakar Rogith, William B Perkison, Susan H Fenton
Faculty, Staff and Student Publications
Background: Remote patient monitoring (RPM) for hypertension management has become increasingly popular, demonstrating benefits for both clinics and patients. However, patient engagement in self-measured blood pressure (SMBP) monitoring remains low despite healthcare providers' efforts. This study aimed to assess adherence and acceptance of RPM for SMBP among Texas Federally Qualified Health Center patients.
Methods: Participants enrolled in the SMBP monitoring program were recruited at three health centers. Data was collected from patient health records, and a questionnaire assessed hypertension self-management, technology acceptance, intentions, and attitudes toward SMBP. Thematic analysis was conducted for open-ended responses that followed each item, and multivariate …
Using Community Engagement To Create A Telecoaching Intervention To Improve Self-Management In Adolescents And Young Adults With Cystic Fibrosis: Qualitative Study., Christina L. Duncan, Emily F. Muther, Jennifer J. Lindwall, Kristine Durkin, Elizabeth Ruvalcaba, Eliza Williamson, Corrine Ahrabi-Nejad, Evelyn Bord, Angela Green, Megan L. Harrison, Deepika Polineni
Using Community Engagement To Create A Telecoaching Intervention To Improve Self-Management In Adolescents And Young Adults With Cystic Fibrosis: Qualitative Study., Christina L. Duncan, Emily F. Muther, Jennifer J. Lindwall, Kristine Durkin, Elizabeth Ruvalcaba, Eliza Williamson, Corrine Ahrabi-Nejad, Evelyn Bord, Angela Green, Megan L. Harrison, Deepika Polineni
Manuscripts, Articles, Book Chapters and Other Papers
BACKGROUND: Adolescents and young adults (AYA) with cystic fibrosis (CF) are at risk for deviating from their daily treatment regimen due to significant time burden, complicated daily therapies, and life stressors. Developing patient-centric, effective, engaging, and practical behavioral interventions is vital to help sustain therapeutically meaningful self-management.
OBJECTIVE: This study aimed to devise and refine a patient-centered telecoaching intervention to foster self-management in AYA with CF using a combination of intervention development approaches, including an evidence- and theory-based approach (ie, applying existing theories and research evidence for behavior change) and a target population-centered approach (ie, intervention refinement based on the …
A Dual Role Of Cohesin In Dna Dsb Repair, Michael Fedkenheuer, Yafang Shang, Seolkyoung Jung, Kevin Fedkenheuer, Solji Park, Davide Mazza, Robin Sebastian, Hiroyuki Nagashima, Dali Zong, Hua Tan, Sushil Kumar Jaiswal, Haiqing Fu, Anthony Cruz, Supriya V Vartak, Jan Wisniewski, Vittorio Sartorelli, John J O'Shea, Laura Elnitski, Andre Nussenzweig, Mirit I Aladjem, Fei-Long Meng, Rafael Casellas
A Dual Role Of Cohesin In Dna Dsb Repair, Michael Fedkenheuer, Yafang Shang, Seolkyoung Jung, Kevin Fedkenheuer, Solji Park, Davide Mazza, Robin Sebastian, Hiroyuki Nagashima, Dali Zong, Hua Tan, Sushil Kumar Jaiswal, Haiqing Fu, Anthony Cruz, Supriya V Vartak, Jan Wisniewski, Vittorio Sartorelli, John J O'Shea, Laura Elnitski, Andre Nussenzweig, Mirit I Aladjem, Fei-Long Meng, Rafael Casellas
Faculty, Staff and Student Publications
Cells undergo tens of thousands of DNA-damaging events each day. Defects in repairing double-stranded breaks (DSBs) can lead to genomic instability, contributing to cancer, genetic disorders, immunological diseases, and developmental defects. Cohesin, a multi-subunit protein complex, plays a crucial role in both chromosome organization and DNA repair by creating architectural loops through chromatin extrusion. However, the mechanisms by which cohesin regulates these distinct processes are not fully understood. In this study, we identify two separate roles for cohesin in DNA repair within mammalian cells. First, cohesin serves as an intrinsic architectural factor that normally prevents interactions between damaged chromatin. Second, …
A Novel Case Of Glial Transdifferentiation In Renal Medullary Carcinoma Brain Metastasis, Maria A Gubbiotti, Ian E Mccutcheon, Priya Rao, Giannicola Genovese, Linghua Wang, Artem Tarasov, Vladislav Putintsev, Amber Berlinski, Danil Stupichev, Kirill Kriukov, Suren Davitavyan, Basim Salem, Alexander Sarachakov, Dmitry Lebedev, Michael Hensley, Alexander Bagaev, Francesca Paradiso, Vladimir Kushnarev, Gleb Khegai, Nizar M Tannir, Pavlos Msaouel
A Novel Case Of Glial Transdifferentiation In Renal Medullary Carcinoma Brain Metastasis, Maria A Gubbiotti, Ian E Mccutcheon, Priya Rao, Giannicola Genovese, Linghua Wang, Artem Tarasov, Vladislav Putintsev, Amber Berlinski, Danil Stupichev, Kirill Kriukov, Suren Davitavyan, Basim Salem, Alexander Sarachakov, Dmitry Lebedev, Michael Hensley, Alexander Bagaev, Francesca Paradiso, Vladimir Kushnarev, Gleb Khegai, Nizar M Tannir, Pavlos Msaouel
Faculty, Staff and Student Publications
Renal medullary carcinoma is a rare undifferentiated tumor of the kidney associated with sickle cell trait and characterized by INI1 (SMARCB1) loss. Although metastasis to lungs, lymph nodes, and bone is commonly reported, distant spread to the central nervous system almost never occurs. Here we present an unusual case of a patient with renal medullary carcinoma with metastasis to the brain following treatment which included tazemetostat, an EZH2 inhibitor. The metastatic brain lesion harbored morphologic, immunohistochemical, and methylation profile supportive of a primary CNS phenotype with loss of the trimethylated lysine 27 residue of histone 3 while maintaining INI1 loss …
Management And Outcome Of Invasive Clindamycin-Resistant Mrsa Community-Associated Infections In Children, Amanda E Macias, Grant Stimes, Sheldon L Kaplan, Jesus G Vallejo, Kristina G Hulten, J Chase Mcneil
Management And Outcome Of Invasive Clindamycin-Resistant Mrsa Community-Associated Infections In Children, Amanda E Macias, Grant Stimes, Sheldon L Kaplan, Jesus G Vallejo, Kristina G Hulten, J Chase Mcneil
Faculty, Staff and Students Publications
Background: Clindamycin resistance among community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) complicates the management of a challenging infection. Little data exist to guide clinicians in the management of invasive clindamycin-resistant CA-MRSA infections in children and studies using oral regimens such as trimethoprim-sulfamethoxazole (TMP-SMX) and linezolid for treatment of these infections are limited. We sought to reevaluate antibiotic management among invasive CA-MRSA at a tertiary children’s hospital.
Methods: Cases of invasive clindamycin-resistant MRSA infections in children were identified through an ongoing S. aureus surveillance study. Eligible cases were those occurring in otherwise healthy children from 2011–2021. Medical records were reviewed.
Results: Thirty-four subjects …
Editorial: Vitamin D And Mineral Ion Homeostasis: Endocrine Dysregulation In Chronic Diseases, Rahnuma Ahmad, Bara Sarraj, Mohammed S. Razzaque
Editorial: Vitamin D And Mineral Ion Homeostasis: Endocrine Dysregulation In Chronic Diseases, Rahnuma Ahmad, Bara Sarraj, Mohammed S. Razzaque
School of Medicine Publications
No abstract provided.
Systematic Ocular Phenotyping Of 8,707 Knockout Mouse Lines Identifies Genes Associated With Abnormal Corneal Phenotypes, Peter Vo, Denise M Imai-Leonard, Benjamin Yang, Andrew Briere, Andy Shao, M Isabel Casanova, David Adams, Takanori Amano, Oana Amarie, Zorana Berberovic, Lynette Bower, Robert Braun, Steve Brown, Samantha Burrill, Soo Young Cho, Sharon Clementson-Mobbs, Abigail D'Souza, Mary Dickinson, Mohammad Eskandarian, Ann M Flenniken, Helmut Fuchs, Valerie Gailus-Durner, Jason Heaney, Yann Hérault, Martin Hrabe De Angelis, Chih-Wei Hsu, Shundan Jin, Russell Joynson, Yeon Kyung Kang, Haerim Kim, Hiroshi Masuya, Hamid Meziane, Steve Murray, Ki-Hoan Nam, Hyuna Noh, Lauryl M J Nutter, Marcela Palkova, Jan Prochazka, Miles Joseph Raishbrook, Fabrice Riet, Jennifer Ryan, Jason Salazar, Zachery Seavey, John Richard Seavitt, Radislav Sedlacek, Mohammed Selloum, Kyoung Yul Seo, Je Kyung Seong, Hae-Sol Shin, Toshihiko Shiroishi, Michelle Stewart, Karen Svenson, Masaru Tamura, Heather Tolentino, Uchechukwu Udensi, Sara Wells, Jacqueline White, Amelia Willett, Janine Wotton, Wolfgang Wurst, Atsushi Yoshiki, International Mouse Phenotyping Consortium, Louise Lanoue, K C Kent Lloyd, Brian C Leonard, Michel J Roux, Colin Mckerlie, Ala Moshiri
Systematic Ocular Phenotyping Of 8,707 Knockout Mouse Lines Identifies Genes Associated With Abnormal Corneal Phenotypes, Peter Vo, Denise M Imai-Leonard, Benjamin Yang, Andrew Briere, Andy Shao, M Isabel Casanova, David Adams, Takanori Amano, Oana Amarie, Zorana Berberovic, Lynette Bower, Robert Braun, Steve Brown, Samantha Burrill, Soo Young Cho, Sharon Clementson-Mobbs, Abigail D'Souza, Mary Dickinson, Mohammad Eskandarian, Ann M Flenniken, Helmut Fuchs, Valerie Gailus-Durner, Jason Heaney, Yann Hérault, Martin Hrabe De Angelis, Chih-Wei Hsu, Shundan Jin, Russell Joynson, Yeon Kyung Kang, Haerim Kim, Hiroshi Masuya, Hamid Meziane, Steve Murray, Ki-Hoan Nam, Hyuna Noh, Lauryl M J Nutter, Marcela Palkova, Jan Prochazka, Miles Joseph Raishbrook, Fabrice Riet, Jennifer Ryan, Jason Salazar, Zachery Seavey, John Richard Seavitt, Radislav Sedlacek, Mohammed Selloum, Kyoung Yul Seo, Je Kyung Seong, Hae-Sol Shin, Toshihiko Shiroishi, Michelle Stewart, Karen Svenson, Masaru Tamura, Heather Tolentino, Uchechukwu Udensi, Sara Wells, Jacqueline White, Amelia Willett, Janine Wotton, Wolfgang Wurst, Atsushi Yoshiki, International Mouse Phenotyping Consortium, Louise Lanoue, K C Kent Lloyd, Brian C Leonard, Michel J Roux, Colin Mckerlie, Ala Moshiri
Faculty, Staff and Students Publications
Purpose: Corneal dysmorphologies (CDs) are typically classified as either regressive degenerative corneal dystrophies (CDtrs) or defective growth and differentiation-driven corneal dysplasias (CDyps). Both eye disorders have multifactorial etiologies. While previous work has elucidated many aspects of CDs, such as presenting symptoms, epidemiology, and pathophysiology, the genetic mechanisms remain incompletely understood. The purpose of this study was to analyze phenotype data from 8,707 knockout mouse lines to identify new genes associated with the development of CDs in humans.
Methods: 8,707 knockout mouse lines phenotyped by the International Mouse Phenotyping Consortium were queried for genes associated with statistically significant (P < 0.0001) abnormal cornea morphology to identify candidate CD genes. Corneal abnormalities were investigated by histopathology. A literature search was used to determine the proportion of candidate genes previously associated with CDs in mice and humans. Phenotypes of human orthologues of mouse candidate genes were compared with known human CD genes to identify protein-protein interactions and molecular pathways using the Search Tool for the Retrieval of Interacting Genes/Proteins (STRING), Protein Analysis Through Evolutionary Relationships (PANTHER), and Kyoto Encyclopedia of Genes and Genomes.
Results: Analysis …
Glofitamab In Relapsed/Refractory Mantle Cell Lymphoma: Results From A Phase I/Ii Study, Tycel Jovelle Phillips, Nancy L Bartlett, Et Al.
Glofitamab In Relapsed/Refractory Mantle Cell Lymphoma: Results From A Phase I/Ii Study, Tycel Jovelle Phillips, Nancy L Bartlett, Et Al.
2020-Current year OA Pubs
PURPOSE: Patients with relapsed/refractory (R/R) mantle cell lymphoma (MCL) have a poor prognosis. The phase I/II NP30179 study (ClinicalTrials.gov identifier: NCT03075696) evaluated glofitamab monotherapy in patients with R/R B-cell lymphomas, with obinutuzumab pretreatment (Gpt) to mitigate the risk of cytokine release syndrome (CRS) with glofitamab. We present data for patients with R/R MCL.
METHODS: Eligible patients with R/R MCL (at least one previous therapy) received Gpt (1,000 or 2,000 mg) 7 days before the first glofitamab dose (single dose or split over 2 days if required). Glofitamab step-up dosing was administered once a day on days 8 (2.5 mg) and …
Modifiable Factors For Irritable Bowel Syndrome: Evidence From Mendelian Randomisation Approach, Di Liu, Meiling Cao, Shanshan Wu, Yiwen Jiang, Weijie Cao, Tengfei Lin, Fuxiao Li, Feng Sha, Zhirong Yang, Jinling Tang
Modifiable Factors For Irritable Bowel Syndrome: Evidence From Mendelian Randomisation Approach, Di Liu, Meiling Cao, Shanshan Wu, Yiwen Jiang, Weijie Cao, Tengfei Lin, Fuxiao Li, Feng Sha, Zhirong Yang, Jinling Tang
Research outputs 2022 to 2026
Background The potential modifiable factors influencing irritable bowel syndrome (IBS) have not been thoroughly documented. We aimed to systematically investigate the modifiable factors associated with IBS, while accounting for the impact of unobserved confounders and coexisting disorders. Methods Genetic correlation and Mendelian randomisation (MR) analyses were integrated to identify potential modifiable factors and coexisting disorders linked to IBS. Subsequently, multiresponse MR (MR 2) was employed to further examine these associations. Summary-level genome-wide association data were used. Modifiable factors and coexisting disorders (ie, gastrointestinal and psychiatric disorders) were identified based on evidence from cohort studies and meta-analysis. In all analyses, IBS …
Decriminalizing Disease: A Health Justice Approach To Infectious Diseases And Criminal Law, Sean E. Bland
Decriminalizing Disease: A Health Justice Approach To Infectious Diseases And Criminal Law, Sean E. Bland
Arkansas Law Review
Infectious diseases, also called communicable diseases, are largely a public health issue and should not be criminalized. This Article seeks to re-frame the discussion around the legal framework for infectious diseases in a way that moves beyond a punishment mindset and toward a health justice mindset. The focus in this Article is on health justice rather than traditional understandings of public health, defined as the science and practice of improving the health of people and their communities. The Article makes three novel contributions. First, it applies a health justice framework to the critique of infectious disease criminalization. Second, the Article …
Feasibility And Acceptability Of The Mazi Umntanakho Digital Tool In South African Settings: A Qualitative Evaluation, Catherine E. Draper, Caylee J. Cook, Elizabeth A. Ankrah, Jesus A. Beltran, Franceli L. Cibrian, Kimberley D. Lakes, Hanna Mofid, Lucretia Williams, Gillian R. Hayes
Feasibility And Acceptability Of The Mazi Umntanakho Digital Tool In South African Settings: A Qualitative Evaluation, Catherine E. Draper, Caylee J. Cook, Elizabeth A. Ankrah, Jesus A. Beltran, Franceli L. Cibrian, Kimberley D. Lakes, Hanna Mofid, Lucretia Williams, Gillian R. Hayes
Engineering Faculty Articles and Research
To address the need for interventions targeting social emotional development and mental health of young children in South Africa, the Mazi Umntanakho (‘know your child’) digital tool was co-designed, and piloted with caregivers and 3–5-year-old children involved in home visiting programmes promoting early childhood development. The aim of this study was to qualitatively evaluate the feasibility and acceptability of this tool in four urban and four rural low-income communities, from the perspective of home visitors and caregivers. Focus groups were conducted with home visitors (n = 117) and caregivers (n = 72). Issues relating to the feasibility of …
The Clinical Utility Of A Next-Generation Sequencing-Based Approach To Detecting Circulating Hpv Dna In Patients With Advanced Anal Cancer, Deepak Bhamidipati, Jay R Johnson, Kangyu Lin, Helene Pelicano, Cathy Eng, Ryan Huey, Robert A Wolff, Daniel M Halperin, Michael F Frumovitz, Ignacio I Wistuba, Dzifa Y Duose, Saradhi Mallampati, Rajyalakshmi Luthra, Van K Morris
The Clinical Utility Of A Next-Generation Sequencing-Based Approach To Detecting Circulating Hpv Dna In Patients With Advanced Anal Cancer, Deepak Bhamidipati, Jay R Johnson, Kangyu Lin, Helene Pelicano, Cathy Eng, Ryan Huey, Robert A Wolff, Daniel M Halperin, Michael F Frumovitz, Ignacio I Wistuba, Dzifa Y Duose, Saradhi Mallampati, Rajyalakshmi Luthra, Van K Morris
Faculty, Staff and Student Publications
Background: To extend the practicality of liquid biopsy beyond the historical HPV circulating tumor DNA (ctDNA) assays, we evaluated the clinical relevance of a novel next-generation sequencing HPV ctDNA assay in patients with locally advanced and metastatic squamous cell cancer of the anal canal (mSCCA).
Methods: ctDNA isolated from the plasma of patients with mSCCA was sequenced using a 1.4 Mb hybrid-capture target-enrichment panel covering the whole genome sequences of all 193 HPV types. The HPV type, copy number (CN), and integration sites were determined using a bioinformatic pipeline.
Results: A total of 77 plasma samples from 28 patients with …
Neighborhood Social Processes And Adolescents' Depressive Symptoms: The Intervening Role Of Neighborhood Self-Efficacy, Kristen A. Berg
Neighborhood Social Processes And Adolescents' Depressive Symptoms: The Intervening Role Of Neighborhood Self-Efficacy, Kristen A. Berg
Faculty Scholarship
Via observational data from the Project on Human Development in Chicago Neighborhoods collected between 1994 and 2001, this study examined the degree to which neighborhood disorder, collective efficacy, and youth-centered institutional resources are directly associated with adolescents' depressive symptoms across time, and the mediating role of adolescents'neighborhood self-efficacy. Latent variable structural equation models were estimated among an unweighted representative sample of 1448 adolescents (59% male, mean age 15.19), across 79 neighborhoods in Chicago, to examine the direct effects of neighborhood disorder, collective efficacy, and availability of youth-centered resources at baseline (measured at timepoint 1; reported by an independent sample of …
The Healing Power Of Antitrust, Theodosia Stavroulaki
The Healing Power Of Antitrust, Theodosia Stavroulaki
Northwestern University Law Review
Millions of Americans live in hospital deserts—communities where people lack geographic access to hospitals and primary care physicians. People living in these deserts often miss doctor appointments, delay necessary care, and stop adhering to their treatment. In this way, hospital deserts exacerbate the health disparities plaguing America. This Article demonstrates that hospital deserts are not inevitable but the result of several business strategies—including noncompete agreements and merging with competitors—and antitrust enforcers’ unwillingness to recognize these harmful practices as antitrust violations. To cure the issue of hospital deserts, this Article makes three proposals. First, antitrust enforcers and the courts should expand …
Niaid Workshop Report: Systematic Approaches For Eskape Bacteria Antigen Discovery, Inka Sastalla, Keehwan Kwon, Clayton Huntley, Kimberly A. Taylor Dnp, Rn, Nea-Bc, Cnor, Clssbb, Liliana Brown, Tamika Samuel, Lanling Zou
Niaid Workshop Report: Systematic Approaches For Eskape Bacteria Antigen Discovery, Inka Sastalla, Keehwan Kwon, Clayton Huntley, Kimberly A. Taylor Dnp, Rn, Nea-Bc, Cnor, Clssbb, Liliana Brown, Tamika Samuel, Lanling Zou
Publications
On 14-15 November 2023, the National Institute of Allergy and Infectious Diseases (NIAID) organized a workshop entitled "Systematic Approaches for ESKAPE Bacteria Antigen Discovery". The goal of the workshop was to engage scientists from diverse relevant backgrounds to explore novel technologies that can be harnessed to identify and address current roadblocks impeding advances in antigen and vaccine discoveries for the ESKAPE pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species). The workshop consisted of four sessions that addressed ESKAPE infections, antigen discovery and vaccine efforts, and new technologies including systems immunology and vaccinology approaches. Each …
Research Progress And Clinical Translation Potential Of Coronary Atherosclerosis Diagnostic Markers From A Genomic Perspective, Hanxiang Liu, Yuchen Zhang, Yueyan Zhao, Yuzhen Li, Xiaofeng Zhang, Lingyu Bao, Rongkai Yan, Yixin Yang, Huixian Zhou, Jinming Zhang, Siyuan Song
Research Progress And Clinical Translation Potential Of Coronary Atherosclerosis Diagnostic Markers From A Genomic Perspective, Hanxiang Liu, Yuchen Zhang, Yueyan Zhao, Yuzhen Li, Xiaofeng Zhang, Lingyu Bao, Rongkai Yan, Yixin Yang, Huixian Zhou, Jinming Zhang, Siyuan Song
Children’s Nutrition Research Center Staff Publications
Objective: Coronary atherosclerosis (CAD) is characterized by arterial intima lipid deposition, chronic inflammation, and fibrous tissue proliferation, leading to arterial wall thickening and lumen narrowing. As the primary cause of coronary heart disease and acute coronary syndrome, CAD significantly impacts global health. Recent genetic studies have demonstrated CAD's polygenic and multifactorial nature, providing molecular insights for early diagnosis and risk assessment. This review analyzes recent advances in CAD-related genetic markers and evaluates their diagnostic potential, focusing on their applications in diagnosis and risk stratification within precision medicine.
Methods: We conducted a systematic review of CAD genomic studies from PubMed and …
Enoxaparin Venous Thromboembolism Prophylaxis Dosing In Critically Ill Underweight Patients., Elizabeth Curcio, Alyssa S Meester, Angela Harding, Marie M Lockhart, John Dillis
Enoxaparin Venous Thromboembolism Prophylaxis Dosing In Critically Ill Underweight Patients., Elizabeth Curcio, Alyssa S Meester, Angela Harding, Marie M Lockhart, John Dillis
Pharmacy Articles
No abstract provided.
Automatic Genetic Phenotype Normalization From Dysmorphology Physical Examinations: An Overview Of The Biocreative Viii-Task 3 Competition, Davy Weissenbacher, Xinwei Zhao, Jessica R C Priestley, Katherine M Szigety, Sarah F Schmidt, Karen O'Connor, Ekin Soysal, Kirk Roberts, Jiewei Qi, Ling Luo, Zhihao Yang, Hongfei Lin, Hajung Kim, Chanhwi Kim, Jiwoong Sohn, Tim Beck, Marek Rei, Sunkyu Kim, T Ian Simpson, Joram M Posma, Antoine Lain, Mujeen Sung, Jaewoo Kang, Areej Alhassan, Viktor Schlegel, Monira Aloud, Riza Batista-Navarro, Goran Nenadic, Ying-Jia Lin, Zhi-Quan Feng, Hung-Yu Kao, Ian M Campbell, Graciela Gonzalez-Hernandez
Automatic Genetic Phenotype Normalization From Dysmorphology Physical Examinations: An Overview Of The Biocreative Viii-Task 3 Competition, Davy Weissenbacher, Xinwei Zhao, Jessica R C Priestley, Katherine M Szigety, Sarah F Schmidt, Karen O'Connor, Ekin Soysal, Kirk Roberts, Jiewei Qi, Ling Luo, Zhihao Yang, Hongfei Lin, Hajung Kim, Chanhwi Kim, Jiwoong Sohn, Tim Beck, Marek Rei, Sunkyu Kim, T Ian Simpson, Joram M Posma, Antoine Lain, Mujeen Sung, Jaewoo Kang, Areej Alhassan, Viktor Schlegel, Monira Aloud, Riza Batista-Navarro, Goran Nenadic, Ying-Jia Lin, Zhi-Quan Feng, Hung-Yu Kao, Ian M Campbell, Graciela Gonzalez-Hernandez
Faculty, Staff and Student Publications
We present here an overview of the BioCreative VIII Task 3 competition, which called for the development of state-of-the-art approaches to automatic normalization of observations noted by physicians in dysmorphology physical examinations to the Human Phenotype Ontology (HPO). We made available for the task 3136 deidentified and manually annotated observations extracted from electronic health records of 1652 paediatric patients at the Children’s Hospital of Philadelphia. This task is challenging due to the discontinuous, overlapping, and descriptive mentions of the observations corresponding to HPO terms, severely limiting the performance of straightforward strict matching approaches. Ultimately, an effective automated solution to the …
A Pathway From Fragmentation To Interoperability Through Standards-Based Enterprise Architecture To Enhance Patient Safety, Zoie Shui-Yee Wong, Yang Gong, Shin Ushiro
A Pathway From Fragmentation To Interoperability Through Standards-Based Enterprise Architecture To Enhance Patient Safety, Zoie Shui-Yee Wong, Yang Gong, Shin Ushiro
Faculty, Staff and Student Publications
Creating an ontology is the essential step in natural language processing (NLP). To improve patient safety in this era of generative AI, it is crucial to develop a standards-driven, ontology-based architecture for patient safety that can seamlessly integrate with health systems, thereby facilitating effective detection and monitoring potentially preventable harms in healthcare. This visionary, whole-system approach to patient safety addresses a significant gap in establishing resilient safety systems within the healthcare sector.
Feasibility Of Ex Vivo Ligandomics, Prabuddha Waduge, Remya Ammassam Veettil, Bojun Zhang, Chengchi Huang, Hong Tian, Wei Li
Feasibility Of Ex Vivo Ligandomics, Prabuddha Waduge, Remya Ammassam Veettil, Bojun Zhang, Chengchi Huang, Hong Tian, Wei Li
Faculty, Staff and Students Publications
We developed ligandomics for the in vivo profiling of vascular ligands in mice, discovering secretogranin III (Scg3) as a novel angiogenic factor that selectively binds to retinal vessels of diabetic but not healthy mice. This discovery led to the development of anti-Scg3 therapy for ocular vasculopathies. However, in vivo ligandomics requires intracardial perfusion to remove unbound phage clones, limiting its use to vascular endothelial cells (ECs). To extend ligandomics to non-vascular cells, we investigated ex vivo ligandomics. We isolated ECs and retinal ganglion cells (RGCs) from diabetic and healthy mouse retinas by immunopanning. We quantified the binding of clonal phages …
Impact Of Stain Variation And Color Normalization For Prognostic Predictions In Pathology, Siyu Lin, Haowen Zhou, Mark Watson, Ramaswamy Govindan, Richard J Cote, Changhuei Yang
Impact Of Stain Variation And Color Normalization For Prognostic Predictions In Pathology, Siyu Lin, Haowen Zhou, Mark Watson, Ramaswamy Govindan, Richard J Cote, Changhuei Yang
2020-Current year OA Pubs
In recent years, deep neural networks (DNNs) have demonstrated remarkable performance in pathology applications, potentially even outperforming expert pathologists due to their ability to learn subtle features from large datasets. One complication in preparing digital pathology datasets for DNN tasks is the variation in tinctorial qualities. A common way to address this is to perform stain normalization on the images. In this study, we show that a well-trained DNN model trained on one batch of histological slides failed to generalize to another batch prepared at a different time from the same tissue blocks, even when stain normalization methods were applied. …
A Data-Driven Latent Variable Approach To Validating The Research Domain Criteria Framework, S K L Quah, B Jo, C Geniesse, L Q Uddin, J A Mumford, D M Barch, D A Fair, I H Gotlib, R A Poldrack, M Saggar
A Data-Driven Latent Variable Approach To Validating The Research Domain Criteria Framework, S K L Quah, B Jo, C Geniesse, L Q Uddin, J A Mumford, D M Barch, D A Fair, I H Gotlib, R A Poldrack, M Saggar
2020-Current year OA Pubs
Despite the widespread use of the Research Domain Criteria (RDoC) framework in psychiatry and neuroscience, recent studies suggest that the RDoC is insufficiently specific or excessively broad relative to the underlying brain circuitry it seeks to elucidate. To address these concerns, we employ a latent variable approach using bifactor analysis. We examine 84 whole-brain task-based fMRI (tfMRI) activation maps from 19 studies with 6192 participants. A curated subset of 37 maps with a balanced representation of RDoC domains constitute the training set, and the remaining held-out maps form the internal validation set. External validation is conducted using 36 peak coordinate …
Differences In Risk Appraisal And Neural Activity In Adolescents With A History Of Misconduct, Elizabeth S Escalante, Jessica S Flannery, Michael T Perino, Eva H Telzer
Differences In Risk Appraisal And Neural Activity In Adolescents With A History Of Misconduct, Elizabeth S Escalante, Jessica S Flannery, Michael T Perino, Eva H Telzer
2020-Current year OA Pubs
While much of the prior work examining the behavioural and neural mechanisms of adolescent risk taking has focused on community samples, less is known about whether these mechanisms apply to adolescents engaging in high levels of risky behaviour. The current study examines behavioural and neural differences between adolescents with (N = 24) and without (N = 35) a history of misconduct using a risk perception questionnaire and risk-taking fMRI task. Adolescents with a history of misconduct perceived fewer negative consequences of risk relative to positive consequences and exhibited altered neural tracking of risk and reward in the nucleus accumbens. Specifically, …
Prevalence Of Flat Foot Among School-Age Girls And Its Relationship With Body Mass Index And Activity Level, Hisham Mohamed Hussein, Ehab Kamel, Walid Mohamed Kamel, Ibrahim Metwally Dewir, Ahmed Abdelmoniem Ibrahim
Prevalence Of Flat Foot Among School-Age Girls And Its Relationship With Body Mass Index And Activity Level, Hisham Mohamed Hussein, Ehab Kamel, Walid Mohamed Kamel, Ibrahim Metwally Dewir, Ahmed Abdelmoniem Ibrahim
Internet Journal of Allied Health Sciences and Practice
Background: The foot and ankle are important structures in the skeletal system of the human body. Deviation in normal structure of the foot,such as in flat foot deformity, can lead to many health problems. Our study aimed to explore the prevalence of flexible flat foot (FFF) among school-age female students in the Ha’il region, Saudi Arabia, and to assess the association between the body mass index (BMI), activity level, and FFF in the selected samples. Materials and Methods: This cross-sectional study included 543 female students between 7 and 12 years of age. Data regarding age, height, weight, level …
Relationship Between Gross Motor Function And Quality Of Life In Children With Unilateral And Bilateral Cerebral Palsy, Ünal Değer, Akmer Mutlu
Relationship Between Gross Motor Function And Quality Of Life In Children With Unilateral And Bilateral Cerebral Palsy, Ünal Değer, Akmer Mutlu
Internet Journal of Allied Health Sciences and Practice
ABSTRACT
Purpose: It is known that quality of life (QoL) is negatively affected in children with cerebral palsy (CP). This study investigated the correlation between gross motor function and QoL in children with unilateral and bilateral CP at levels I and II according to the Gross Motor Classification System. Methods: Fourty individuals with CP, ages between 8-18 years, were included in this study. The Gross Motor Function Measure (GMFM) was used to evaluate the children’s gross motor functions, and the Gross Motor Function Classification System (GMFCS) was used to determine levels. QoL was evaluated with the Quality of Life …
Mantra Meditation For Chronically Impaired Attention After Stroke: A Trial Using Single-Case Experimental Design, Cheryl Carrico, Dana Howell, John A. Patterson, Richard D. Andreatta, Camille Skubik-Peplaski
Mantra Meditation For Chronically Impaired Attention After Stroke: A Trial Using Single-Case Experimental Design, Cheryl Carrico, Dana Howell, John A. Patterson, Richard D. Andreatta, Camille Skubik-Peplaski
Internet Journal of Allied Health Sciences and Practice
Purpose: Impaired attention after stroke is a common problem for which rehabilitation would potentially be indicated. Systematic review evidence has revealed a lack of high-quality research that supports the effectiveness of standard-of-care cognitive rehabilitation for sustained attention, alertness, and functional impact on daily life after stroke. Standard-of-care cognitive rehabilitation does not include meditation. Meditation has been defined in contemporary scientific literature as a regime entailing voluntary self-regulation of attention. As such, meditation could potentially improve attention in keeping with tenets of neuroplasticity. The present study investigated whether mantra meditation would benefit attention for adults with chronically impaired attention after right-hemisphere …
Physiotherapists' Knowledge Of Ageing And Its Associated Factors, Unyime Jasper, Olayinka Akinrolie, Cornelius Mahdi Ishaku, Nnamdi Mgbemena
Physiotherapists' Knowledge Of Ageing And Its Associated Factors, Unyime Jasper, Olayinka Akinrolie, Cornelius Mahdi Ishaku, Nnamdi Mgbemena
Internet Journal of Allied Health Sciences and Practice
Purpose: To evaluate knowledge of ageing and its associated factors among Nigerian physiotherapists (PTs).
Methods: We used a three-part questionnaire. Knowledge of ageing was evaluated with Palmore’s Facts on Aging Quiz (FAQ). Certain questions in the FAQ were modified to reflect the local setting. We conducted a validity and reliability check on the questionnaire using test-retest with 10 PTs. Data were analysed using descriptive statistics, t-test, ANOVA and multiple linear regression.
Resullts: Out of 204 PTs invited, 186 agreed to participate. Test-retest of the FAQ revealed a Cronbach alpha of 0.78. The age of participants ranged from …
Prevalence And Efficacy Of Coping Strategies Utilized By Entry-Level Occupational Therapy Students, Elena Wong Espiritu, Natalie N. Michaels, Caitlin Bender, Megan M. Cusick, D. Rachel Hicks, Hanna Mcclain, Lavanya Reddy, Samantha Wu
Prevalence And Efficacy Of Coping Strategies Utilized By Entry-Level Occupational Therapy Students, Elena Wong Espiritu, Natalie N. Michaels, Caitlin Bender, Megan M. Cusick, D. Rachel Hicks, Hanna Mcclain, Lavanya Reddy, Samantha Wu
Internet Journal of Allied Health Sciences and Practice
Abstract
Background: Stress among occupational therapy graduate students has continued to increase over the last decade due to high academic expectations, difficulty integrating didactic and clinical knowledge, intense class schedules, financial strain, and difficulty balancing work, school, leisure pursuits, and social participation. However, there is limited evidence in the current literature addressing coping strategies used by entry-level occupational therapy students in response to stressors. Purpose: The purpose of this study was to identify which coping strategies occupational therapy students most commonly use, and to describe which coping strategies they found to be most and least effective from the student perspective. …
Rapid Weight Regain Is Not Linked To Success In Professional Ufc Fighters During Competition, Antonella V. Schwarz, Peter J. Byers, Lauren Stern, Gabriel J. Sanders, Tobin Silver, Jose Antonio, Corey Peacock
Rapid Weight Regain Is Not Linked To Success In Professional Ufc Fighters During Competition, Antonella V. Schwarz, Peter J. Byers, Lauren Stern, Gabriel J. Sanders, Tobin Silver, Jose Antonio, Corey Peacock
Internet Journal of Allied Health Sciences and Practice
Background: Although previous research has explored rapid weight loss (RWL) and rapid weight regain (RWRG) of Mixed Martial Arts (MMA) athletes, there is a lack of research analyzing this in fighters for the Ultimate Fighting Championship (UFC). There is also a lack of literature analyzing how RWRG in MMA athletes affects performance outcomes. Therefore, the purpose of this study was to compare official versus fight-night weigh-ins and whether the percentage change influenced winning or losing records in UFC athletes. Methods: Twenty-four official and fight-night weights were obtained utilizing the commission-calibrated scale. Paired Samples T-Tests were utilized to determine if official …
The Effect Of Occupational Therapy Intervention Based On A Multicontext Approach In A Patient With Traumatic Brain Injury: A Case Study, Medine Nur Özata Değerli, Yusuf İslam Değerli, Selen Aydöner
The Effect Of Occupational Therapy Intervention Based On A Multicontext Approach In A Patient With Traumatic Brain Injury: A Case Study, Medine Nur Özata Değerli, Yusuf İslam Değerli, Selen Aydöner
Internet Journal of Allied Health Sciences and Practice
After traumatic brain injury, individuals often experience a variety of cognitive problems. Executive function skills are usually affected, including planning, motivation, multitasking, flexible thinking, performance monitoring, memory, self-awareness, and error detection and correction. Problems in executive function skills can lead to reduced performance of instrumental activities of daily living and dependence on others for these activities in individuals with traumatic brain injury. The multicontext approach is a framework built on the combination of remedial and compensatory techniques that focuses on generalizing learning transfer in cognitive rehabilitation. This study examined the effect of an 8-week multicontext occupational therapy intervention on cognitive …