Medicine and Health Sciences Commons^™

Outcomes Of Pregnant Icu Patients With Severe Covid-19 Pneumonia In Qatar During The Three Waves Of The Covid-19 Pandemic: A Retrospective Cohort Study, Layla J.M Kily, Sohel M.G Ahmed, Tamam A.K.M Alhusban, Mohammed J. Orompurath, Marcus Lance, Mogahed I.H Hussein, Salwa M. Abuyaqoub, Huda A. Saleh, Eynas Abdalla, Santhosh Gopalakrishnan

Anaesthesiology, East Africa

Introduction: Pregnant women are considered a high-risk group for COVID-19 infection/pneumonia as they are known to be more vulnerable to viral infections. They require close monitoring and appropriate timely intervention to minimize the impact on both the mother and the fetus. Although the more prevalent Omicron variant led to fewer severe infections and fewer intensive care unit (ICU) admissions globally during the third wave, the effect on pregnant women and pregnancy outcomes was unknown. The vaccination campaign was thoroughly established by the third wave of the pandemic in Qatar. This retrospective descriptive cohort study investigates the characteristics, hospital stay, interventions, …

The Wellness Connection February 2025, Roger Williams University School Of Law Office Of Student Life

Life of the Law School (1993- )

No abstract provided.

State Laws Leveraging The Community Eligibility Provision To Build Healthy School Meals For All: A Content Analysis, Elizabeth Piekarz-Porter, Juliana F.W. Cohen, Rebecca M. Schermbeck, Julien Leider, Tanya Agurs-Collins, Jamie F. Chriqui

Health Sciences Faculty Publications

No abstract provided.

Accuracy Of Sagemotion Imu-Tactor With Knee Hyperextension During Gait, Peter Beach, Peter Jang, Maddy Wagar, Andrew Meszaros

Student-Faculty Research - College of Physical Therapy

Haptic feedback refers to the external vibratory cue that is activated by data picked up by an Inertial Measurement Unit (IMU) that senses joint position (Figure 1). ❏ Position-driven haptic touch input can give feedback on movement in real-time (Meszaros, 2019) ❏ Original goal: to reduce knee hyperextension during gait using haptic-feedback driven by an IMU-based angle sensor (Sagemotion) ❏ Concerns arose on the validity of IMU/tactor to accurately sense joint position and past research identified a delay between IMU and joint position.

Blood Flow Restriction To Expedite Acute Concussion Recovery: A Literature Review, Eddie Dudum, Madeleine O’Hare, Madeleine O’Hare, Caleb Rauch, Ashlee Rising, Scott Burkhart

Student-Faculty Research - College of Physical Therapy

Blood flow restriction (BFR) is increasing in popularity to help patients more efficiently recover from musculoskeletal injuries. The safety of BFR is well studied1 • There are no studies to date on the use of BFR in acute concussion recovery

Associations Between Physical Performance, Activity, And Reported Ability To Participate In Social Roles In Older Adults, Theresa Raudsepp, Christen Johnson, Isabella Mansley, Kaelynn Miller-Savoy, Karlie Stewart, Molly Shields, Jeff Houck

Student-Faculty Research - College of Physical Therapy

APTA recommends that all individuals visit a Physical Therapist annually to “optimize movement, and promote health, wellness, and fitness” Geriatrics SIG developed a template for these visits for older adults Template includes outcome measures for both body functions and structure, activity domains

Does Self-Soft Tissue Mobilization Of Obturator Internus Reduce Nonrelaxing Pelvic Floor Dysfunction?, Tess Swake, Katherine Briggs, Darschelle Desronvil, Caryn Jagla, Camille Jouzeau

Student-Faculty Research - College of Physical Therapy

The Obturator Internus (OI) is a muscle deep within the pelvis. This muscle is unique by being a muscle of the pelvic floor as well as a muscle of the hip. Currently, there’s limited research concerning the pelvic floor, especially regarding the rehabilitation of conditions related to Pelvic Floor Dysfunction (PFD), however, manual techniques addressing Obturator Internus tension are indicated as a treatment to reduce dysfunction with soft tissue mobilization. The goal of this research is to assess if self-soft tissue mobilization of the OI muscle is beneficial for active females with relaxing or nonrelaxing PFD or hip pain, and …

Changes In Rectus Femoris Strength And Size With Daily Single Leg Bfr Vs Daily Non-Bfr Training In Recreationally Active Individuals, Terrell Kopping, Dj Wilson, Kenzie Ward, Kaileigh Dietrich-Denton,, Bethany Nguyen, Jason Brumitt

Student-Faculty Research - College of Physical Therapy

Blood flow restriction (BFR) utilizes a controlled form of arterial and venous occlusion during resistance exercise.

Resistance training closer to an individual’s one repetition maximum (1RM) (e.g., 70% or higher) has been found to elicit increases in muscle strength and size.1-5

BFR training at lower loads (e.g., 20-30% 1RM) can lead to increases in muscle hypertrophy and strength without the muscle damage associated with training at heavier loads.

Finger Touch And Trunk Haptics Impact Com Control During Vr Perturbations, Ally Wong, Caitlyn Ward, Robin Dorociak, Andrew Meszaros

Student-Faculty Research - College of Physical Therapy

CDC reports that falls in the US cost $50 billion per year. Previous research has indicated that light touch is a strategy that humans rely on to maintain upright (Baldan, et al). Assistive devices are often used for increased proprioception, but requires use of both or one upper extremity. The use of a wearable haptic sway vest allows for participation in bimanual tasks while decreasing risk of falls. This is crucial for the older population to maintain functional independence.

Influences On Peak Effort During 1 Minute Sit To Stand Test, Claire Davidson, Maggie Smith, Destinee Thomas, Taylor Wright, Rebecca Dobler, Jeff Houck

Student-Faculty Research - College of Physical Therapy

The purpose of this study is to determine the influences of peak effort in participants with knee pain and/or knee osteoarthritis during a 1 minute sit to stand test, and new approaches in knee pain education. Many individuals with knee osteoarthritis (OA) may assume that engaging in physical activity could exacerbate their condition. As a result, they may refrain from participating in activities they enjoy due to concerns about worsening symptoms or the progression of OA in their knee. It has been shown in research that if we as clinicians, and other healthcare professionals shift the impairment based talk, individuals …

Nrf2/Cyclooxygenase 2 Signaling In Cr(Vi)-Induced Carcinogenesis, Lei Zhao, Yi-Fang Wang, Andrea Adamcakova-Dodd, Peter Thorne, Ranakul Islam, Ke Jian Liu, Fei Chen, Jia Luo, Ling-Zhi Liu

Kimmel Cancer Center Faculty Papers

Long-term exposure to hexavalent chromium [Cr(VI)] has been linked to lung cancer, and cyclooxygenase-2 (COX-2) is a well-known inflammatory factor. However, the role and mechanism of COX-2 in Cr(VI)-induced carcinogenesis are not clear yet. To address this question, we employed a mouse model exposed to Cr(VI) through intranasal instillation of particulate zinc chromate (ZnCrO4) for 12 weeks. Metabolomics and RNA-seq assays revealed enhanced activity of the arachidonic acid (AA)/eicosanoid metabolism pathway in lung tissues from mice exposed to Cr(VI). COX-2, the key enzyme of the AA/eicosanoid pathway, was significantly upre- gulated in Cr(VI)-exposed lung tissues, as well as in the …

Counseling Students’ Perceptions Of Support During The Covid-19 Crisis: A Qualitative Study., Breahannah Hilarie, Galaxina G. Wright, Lea H., Laurie O. Campbell

Faculty Publications

The COVID-19 pandemic changed the counseling programs in clinical instruction, mentorship, and student’s perception of the university. The qualitative data presented in this paper identifies eight counseling students’ beliefs of support during their time in counseling program during the COVID-19 pandemic. Data was obtained through semi-structured interviews. An interpretive phenomenological analysis resulted in four themes: including higher education response, personal resources, emotions in crisis, and transitions in crisis.

Five-Year Outcomes Of Lenadogene Nolparvovec Gene Therapy In Leber Hereditary Optic Neuropathy, Patrick Yu-Wai-Man, Nancy Newman, Valérie Biousse, Valerio Carelli, Mark Moster, Catherine Vignal-Clermont, Thomas Klopstock, Alfredo Sadun, Robert C Sergott, Rabih Hage, Simona Degli Esposti, Chiara La Morgia, Claudia Priglinger, Rustum Karanja, Magali Taiel, José-Alain Sahel

Department of Neurology Faculty Papers

IMPORTANCE: Limited studies have assessed the long-term benefit/risk of gene therapy for Leber hereditary optic neuropathy (LHON).

OBJECTIVE: To determine the safety and efficacy of lenadogene nolparvovec in patients with LHON due to the MT-ND4 gene variant for up to 5 years after administration.

DESIGN, SETTING, AND PARTICIPANTS: The RESCUE and REVERSE Long-Term Follow-up Study (RESTORE), conducted from 2018 to 2022, is the 5-year follow-up study of the 2 phase 3 clinical studies RESCUE (Efficacy Study of Lenadogene Nolparvovec for the Treatment of Vision Loss Up to 6 Months From Onset in LHON Due to the MT-ND4 Mutation) and REVERSE …

Sex-Specific And Regional Analysis Of Heart Disease Prediction Using Machine Learning Algorithms: Insights From The Uc Irvine Public Heart Disease Datasets (Cleveland And Long Beach), Jonathan Asanjarani

Dissertations, Theses, and Capstone Projects

For this capstone project, I investigated how well machine learning models can predict heart disease, while also studying how the patient’s gender affects these predictions, as well as determining how well the same model performs across different regions. This project utilizes two clinical datasets from the publicly accessible UCI Machine Learning Repository under the collection "Heart Disease." This repository is composed of data from patients across four distinct locations, capturing varying levels of heart disease severity. These datasets are part of a collection of databases, open to the public, and can be used by anyone looking to conduct empirical analysis. …

Vertex-Based Analysis Of Cerebral Blood Flow And Fractional Amplitude Of Low-Frequency Fluctuations (Cbf-Falff) Coupling In Moderate-To-Severe Traumatic Brain Injury During The First Year Post-Injury, Vaidehi Hemkumar Patel

Dissertations, Theses, and Capstone Projects

Traumatic brain injury (TBI) is known to involve damage in the neurovascular unit. TBI may disrupt the brain’s neurovascular coupling–the relationship between cerebral blood flow and neural activity–that can lead to cognitive and functional impairments. This study attempted to non-invasively investigate neurovascular coupling in patients with moderate to severe TBI (msTBI) during the first year post-injury using a combined metric of cerebral blood flow (CBF) and fractional amplitude of low-frequency fluctuations (fALFF), a proxy for spontaneous neural activity. Using arterial spin labeling (ASL) and functional MRI sequences, CBF and fALFF were measured in 29 msTBI patients 3-, 6- and 12-months …

Expanding The Healthy Project: Assessing Health Literacy And Health Information Navigational Skills In High School Youth, Isaac Perez, John Ronnau, Eron Manusov

MEDI 9331 Scholarly Activities Clinical Years

Addressing the gaps identified by previous health literacy assessments in the Rio Grande Valley, this study evaluated an educational intervention aiming to enhance eHealth literacy among adolescents at a Title I high school by incorporating peer-to-peer education that targeted state educational standards for high school health science courses. Results demonstrated a statistically significant improvement in students' mean eHEALS scores by 6.56%, notably in using online health resources effectively. However, students' abilities to critically evaluate health information showed less improvement. Although statistically significant, the practical relevance of these improvements on students' real-world health-seeking behaviors requires further investigation, pointing to the necessity …

A Personalized Periodontitis Risk Based On Nonimage Electronic Dental Records By Machine Learning, Laura Swinckels, Ander De Keijzer, Bruno G. Loos, Reuben Joseph Applegate, Krishna Kumar Kookal, Elsbeth Kalenderian, Harmen Bijwaard, Josef Bruers

School of Dentistry Faculty Research and Publications

Objective: This study aimed to develop a machine-learning (ML) model to predict the risk for Periodontal Disease (PD) based on nonimage electronic dental records (EDRs).

Methods: By using EDRs collected in the BigMouth repository, dental patients from the US were included. Patients were labeled as cases or controls, based on PD diagnosis, treatment and pocketing. By learning from their data, a model was trained. The ability of the developed model to predict PD was evaluated by the accuracy, sensitivity, specificity and area under the curve (AUROC) and the most important features were determined. The best-performing model was applied …

Efficacy Of 3d-Printed Chitosan-Cerium Oxide Dressings Coated With Vancomycin-Loaded Alginate For Chronic Wounds Management, Sharareh Shahroudi, Amir Parvinnasab, Erfan Salahinejad, Shaghayegh Abdi, Sarah Rajabi, Lobat Tayebi

School of Dentistry Faculty Research and Publications

Multifunctional wound dressings with antibacterial and antioxidant properties hold significant promise for treating chronic wounds; however, achieving a balance of these characteristics while maintaining biocompatibility is challenging. To enhance this balance, this study focuses on the design and development of 3D-printed chitosan-matrix composite scaffolds, which are incorporated with varying amounts of cerium oxide nanoparticles (0, 1, 3, 5, and 7 wt%) and subsequently coated with a vancomycin-loaded alginate layer. The structure, antibiotic drug delivery kinetics, biodegradation, swelling, biocompatibility, antibacterial, antioxidant, and cell migration behaviors of the fabricated dressings were evaluated in-vitro. The findings reveal that all of the formulations …

The Influence Of A Deep Learning Tool On The Performance Of Oral And Maxillofacial Radiologists In The Detection Of Apical Radiolucencies, Manal Hamdan, Sergio E. Uribe, Lyudmila Tuzova, Dmitry Tuzoff, Zaid Badr, Andre Mol, Donald A. Tyndall

School of Dentistry Faculty Research and Publications

Objectives

This study aimed to assess the impact of a deep learning model on oral radiologists’ ability to detect periapical radiolucencies on periapical radiographs. The secondary objective was to conduct a regression analysis to evaluate the effects of years of experience, time to diagnose, and specialty.

Methods

This study used an annotated dataset and a beta version of a deep learning model (Denti.AI). The testing subset comprised 68 intraoral periapical radiographs confirmed with cone-beam computed tomography for the presence/absence of apical radiolucencies. Four oral radiologists participated in a cross-over reading scenario, analysing the radiographs under 2 conditions: initially without AI …

Pacific Rxtracts - February 2025, Pacific Rxtracts

Pacific RxTracts

Articles:

• Revolutionizing Hypertension Screening: AI-Enhanced ECG as a Proactive Healthcare Tool
• Breaking News:
  • New Indication for Zepbound
  • FDA Approves Injectable Nivolumab: A New Era for Opdivo in Cancer Care
  • Stromal Stem Cells for Steroid-Refractory Acute Graft-vs-Host Disease
• Cardiology:
  • Beta Blocker vs. Verapamil Therapy for Hypertrophic Cardiomyopathy
• General News:
  • Prolactin-Increasing Antipsychotics Increase the Odds of Breast Cancer
  • Hope for a Cytomegalovirus Vaccine: mRNA-1647
  • Targeting IL-13: Innovations in the Treatment of Atopic Dermatitis
  • Beyond Opioids: Multimodal Pain Management in Colorectal Surgery
  • A Nanomaterial Dosage Form for Mupirocin
  • Guselkumab, a potential drug for Ulcerative colitis
• Neuropsychiatry:
  • Dextromethorphan for Depression: More For Just a …

A Model For Advocacy: Advancing Policy Change In Support For Patients With Medicaid, Betsy J. Becker, Jenae Pope

Posters and Presentations: Physical Therapy

There are differences in access and utilization of care for patients with Medicaid. When patients cannot access timely therapeutic care, the resulting outcomes are often poor. Because a major limiting factor in accessing services is insurance type, investigating optimal coverage practices is an important first step in advocating for change. This abstract reports on Phase One of a larger collaboration with state professional associations for physical therapy (PT), occupational therapy (OT), and speech-language pathology (SLP) to present a model that describes Medicaid authorization services for PT, OT, and SLP, serving as a guide for policy change.

We collaborated with the …

Spock2 Controls The Proliferation And Function Of Immature Pancreatic Β-Cells Through Mmp2, Katarzyna Blaszczyk, Anna P Jedrzejak, Natalia Ziojla, Ekaterina Shcheglova, Karolina Szarafin, Artur Jankowski, Christine A Beamish, Jolanta Chmielowiec, Omaima M Sabek, Ashok Balasubramanyam, Sanjeet Patel, Malgorzata Borowiak

Faculty, Staff and Students Publications

Human pluripotent stem cell-derived β-cells (SC-β-cells) represent an alternative cell source for transplantation in diabetic patients. Although mitogens could in theory be used to expand β-cells, adult β-cells very rarely replicate. In contrast, newly formed β-cells, including SC-β-cells, display higher proliferative capacity and distinct transcriptional and functional profiles. Through bidirectional expression modulation and single-cell RNA-seq, we identified SPOCK2, an ECM protein, as an inhibitor of immature β-cell proliferation. Human β-cells lacking SPOCK2 presented elevated MMP2 expression and activity, leading to β-integrin-FAK-c-JUN pathway activation. Treatment with the MMP2 protein resulted in pronounced short- and long-term SC-β-cell expansion, significantly increasing glucose-stimulated insulin …

Effectiveness Of Postoperative Cephalosporins In Reducing Urinary Tract Infections And Other Parameters Following Transurethral Resection Of The Prostate: A Systematic Review And Meta-Analysis, Wael Hafez, Feras Al-Obeidat, Asrar Rashid, Arun Kumar Venkatachalapathi, Amr Massaod, Ziad Albaha, Samy Kishk, Tesfalidet Emoshe, Samuel Tesfaye Tefera, Ismail A. Ibrahim, Mohammad Alkammar, Gowhar Rashid, Ahmed Fayed, Karim Soliman, Abdulqadir J. Nashwan, Alaaldeen Mohamed, Daniel Simancas-Racines, Ivan Cherrez-Ojeda

All Works

No abstract provided.

Changes In Energy Homeostasis, Gut Peptides, And Gut Microbiota In Emiratis With Obesity After Bariatric Surgery, Manal Ali Ahmad, Koen Venema, Carole Ayoub Moubareck, Gabi Wazz, Tarek Mahdy, Mirey Karavetian

All Works

Background Obesity is a growing health concern worldwide, including United Arab Emirates. Bariatric surgery is an effective treatment option, with to date unclear weight loss mechanisms. In this prospective study, we explored post-bariatric surgery changes in energy homeostasis, gut peptides, hormones, and gut microbiota. Method We recruited 19 Emirati adults who were planning to undergo sleeve gastrectomy (SG). We assessed the energy requirements using 24-hour diet recalls, indirect calorimetry for resting energy expenditure (REE), and a questionnaire for appetite. Anthropometrics included body mass index (BMI), waist circumference, waist-to-height ratio, fat mass, fat-free mass, and percentage of body fat. Gut peptides, …

Fluorine-Containing Isosteres Enable A Structure-Activity Relationship Study Of Gingerol Derivatives, Shelby Cooper, Diarta Kabashi, Marlin Yacoub, Jessica Molen, Osman Farhan, Christina Farley, Samantha Yencha, Michelle Figueiredo, Nidheesh Phadnis, Wynter Henry, Julian Harris, Frank Wilkinson, John Milligan

College of Life Sciences Faculty Papers

A series of fluorinated and non-fluorinated [6]-gingerol, [6]-paradol, [6]-shogaol and ferulate derivatives were synthesized. Testing these analogs in anti-proliferation assays with MCF-7, A549, HCT-116 and HEK-293 cell lines provided insight into the structural features that contribute to the anti-proliferative activity of naturally occurring ginger constituents. In particular, the use of both vinyl and alkyl trifluoromethyl isosteres allowed us to evaluate the structure-activity impact of the enone motif found in shogaols. Our results indicate that enone-containing derivatives have a higher potency, suggesting the conjugated enone motif characteristic of shogaols may be primarily responsible for the anti-cancer activity of the broader natural …

Reply To: Amplifying Women's Voices In Menopause Research: The Importance Of Inclusive Perspectives [Letter], Camille Cronin, Sara Donevant Phd, Rn, Ccrn, Kerri-Ann Hughes, Marja Kaunonen, Jette Marcussen, Rhonda Wilson

Publications

No abstract provided.

Amplifying Women's Voices In Menopause Research: The Importance Of Inclusive Perspectives, Camille Cronin, Sara Donevant Phd, Rn, Ccrn, Kerri Ann Hughes, Marja Kaunonen, Jette Marcussen, Rhonda Wilson

Publications

Menopause, a significant life transition for half the global population, intersects biological, cultural and social dimensions. Despite its universal occurrence, menopause research has historically been dominated by biomedical perspectives, often neglecting women's voices and diverse experiences. This article highlights the importance of including women's perspectives in menopause research to ensure relevance, accuracy and equity. It explores cultural variations in menopause experiences, the impact of socioeconomic status and the often-overlooked emotional and psychological dimensions. This article advocates for participatory approaches, emphasising that women's involvement enhances research design, implementation and policy development. Evidence-based interventions that are tailored to the individual can better …

The Built Environment And Place Attachment: Insights From Japanese Cities, Juiling Li, Mohammed Javad Koohsari, Andrew T. Kaczynski, Ryo Tanimoto, Reo Watanabe, Tomoki Nakaya, Yufeng Luo, Jing Zhao, Akitomo Yasunaga, Koichiro Oka, Tomoya Hanibuchi

Faculty Publications

Objective

Methods

Results

Multi-Cancer Early Detection Tests: Attributes For Clinical Implementation, Jon O. Ebbert, Ernest T. Hawk, Christopher V. Chambers, Margaret A. Tempero, Elliot K. Fishman, Jospeh E. Ravenell, Tomasz M. Beer, Seema P. Rego

Department of Family & Community Medicine Faculty Papers

Guideline-recommended screening programs exist for only a few single-cancer types, and these cancers represent less than one-half of all new cancer cases diagnosed each year in the U.S. In addition, these "single-cancer" standard of care (SoC) screening tests vary in accuracy, adherence, and effectiveness, though all are generally understood to lead to reductions in cancer-related mortality. Recent advances in high-throughput technologies and machine learning have facilitated the development of blood-based multi-cancer early detection (MCED) tests. The opportunity for early detection of multiple cancers with a single blood test holds promise in addressing the current unmet need in cancer screening. By …

The Scoop, Vol. 11 Issue 11, February 2025, Health Sciences Library

Volume 11

Latest news and updates from the Health Sciences Library in our monthly newsletter for February 2025. Please see page 2 for a text-only version of this issue!