Medicine and Health Sciences Commons^™

Efficacy And Safety Of Nivolumab Plus Ipilimumab In Patients With Metastatic Variant Histology (Non-Clear Cell) Renal Cell Carcinoma, Mohammad Jad Moussa, Jaanki Khandelwal, Nathaniel R Wilson, Kiran L Malikayil, Devaki Shilpa Surasi, Tharakeswara K Bathala, Yiyun Lin, Priya Rao, Pheroze Tamboli, Kanishka Sircar, Helen Ajufo, Khaled M Elsayes, Amishi Shah, Andrew C Johns, Sangeeta Goswami, Elshad Hasanov, Eric Jonasch, Pavlos Msaouel, Matthew T Campbell, Omar Alhalabi, Nizar M Tannir

Faculty, Staff and Student Publications

Background: Nivolumab plus ipilimumab (nivo/ipi) is a standard of care first-line (1 L) therapy for patients with metastatic clear-cell renal cell carcinoma (ccRCC), but its role in patients with metastatic, non-ccRCC has not been fully defined. We report a single-institution experience with nivo/ipi in non-ccRCC.

Methods: Between November 2017 and February 2024, 55 patients with metastatic non-ccRCC received nivo/ipi at MD Anderson Cancer Center. The tumor response was assessed by blinded radiologists using RECIST v1.1. The overall response rate (ORR), progression-free survival (PFS), PFS milestone, duration of response (DoR), and overall survival (OS) were determined. Next-generation sequencing (NGS) was performed …

Assessment Of Environmental, Sociocultural, And Physiological Influences On Women's Toileting Decisions And Behaviors Using "Where I Go": Pilot Study Of A Mobile App, Abigail R Smith, Elizabeth R Mueller, Cora E Lewis, Alayne Markland, Caroline Smerdon, Ariana L Smith, Siobhan Sutcliffe, Jean F Wyman, Lisa Kane Low, Janis M Miller

2020-Current year OA Pubs

BACKGROUND: Little is known about women's decisions around toileting for urination and how those decisions influence moment-to-moment behaviors to manage bladder needs. The new smartphone app "Where I Go" captures such nuanced and granular data in real-world environments.

OBJECTIVE: This study aims to describe participant engagement with "Where I Go", variation in novel parameters collected, and readiness for the data collection tool's use in population-based studies.

METHODS: "Where I Go" has three components: (1) real-time data, (2) short look-back periods (3-4 h), and (3) event location (GPS recorded at each interaction). The sample size was 44 women. Recording of real-time …

Dna Immunotherapy For Recurrent Respiratory Papillomatosis (Rrp): Phase 1/2 Study Assessing Efficacy, Safety, And Immunogenicity Of Ino-3107, Matthew P Morrow, Randal C Paniello, Et Al.

2020-Current year OA Pubs

Recurrent respiratory papillomatosis (RRP) is a chronic airway disease caused by Human Papillomavirus (HPV). INO-3107, DNA immunotherapy designed to elicit T-cells against HPV-6 and HPV-11, was evaluated in a 52-week Phase 1/2 study for efficacy, safety, and immunogenicity (NCT04398433). Thirty-two eligible adults with HPV-6 and/or HPV-11 RRP, requiring ≥2 surgical interventions in the year preceding dosing were enrolled between October 2020 and November 2021 and administered 4 INO-3107 doses by intramuscular injection followed by electroporation. The primary endpoint was safety and tolerability, as assessed by treatment-emergent adverse events (TEAEs). Secondary endpoints included surgical intervention frequency and change in RRP Severity …

Phgdh Inhibition And Foxo3 Modulation Drives Puma-Dependent Apoptosis In Osteosarcoma, Toshinao Oyama, Caitlyn B Brashears, Richa Rathore, Heather Benect-Hamilton, Katharine E Caldwell, Naomi Dirckx, William G Hawkins, Brian A Van Tine

2020-Current year OA Pubs

Osteosarcoma is a bone cancer that has been found to be metabolically dependent on the conversion of glucose to serine through the rate-limiting enzyme 3-phosphoglycerate dehydrogenase (PHGDH). The upregulation of PHGDH has been correlated with poor patient survival, and the inhibition of the serine synthesis pathway using targeted small-molecule inhibition of PHGDH induces a rapid metabolic adaptation that prevents cell death due to pro-survival signaling through the mammalian target of rapamycin complex 1 (mTORC1) pathway. Here, PHGDH inhibition in combination with mTORC1 signaling modulation for the treatment of osteosarcoma was evaluated. When combined with PHGDH inhibition, several non-rapalog inhibitors of …

Handshake Antimicrobial Stewardship For Adult Surgical Patients, Abby Kosharek, Elizabeth Neuner, Emily Welch, Spenser January, Alice Bewley, Kevin Hsueh, Sena Sayood

2020-Current year OA Pubs

OBJECTIVE: Evaluate the effects of handshake stewardship on adult general surgical units.

DESIGN: Retrospective quasi-experimental pre- and post-intervention study.

SETTING: A total of 1,278 bed academic medical center with a level 1 trauma center in St. Louis, Missouri.

PATIENTS: Adults admitted to general surgery units.

INTERVENTION: Once weekly handshake antimicrobial stewardship rounds were initiated in January 2022 on adult general surgery units. The handshake stewardship team consisted of an infectious diseases (ID) physician and pharmacist who reviewed charts of patients receiving systemic antimicrobials without a formal ID consult. Antimicrobial recommendations were delivered in person to general surgery teams including trauma, …

The Mir-290 And Mir-302 Clusters Are Essential For Reprogramming Of Fibroblasts To Induced Pluripotent Stem Cells, Julia Ye, Ryan M Boileau, Ronald J Parchem, Robert L Judson-Torres, Robert Blelloch

Faculty, Staff and Students Publications

The miR-290 and miR-302 clusters of microRNAs are highly expressed in naïve and primed pluripotent stem cells, respectively. Ectopic expression of the embryonic stem cell (ESC)-specific cell cycle regulating family of microRNAs arising from these two clusters dramatically enhances the reprogramming of both mouse and human somatic cells to induced pluripotency. Here, we used genetic knockouts to dissect the requirement for the miR-290 and miR-302 clusters during the reprogramming of mouse fibroblasts into induced pluripotent stem cells (iPSCs) with retrovirally introduced Oct4, Sox2, and Klf4. Knockout of either cluster alone did not negatively impact the efficiency of reprogramming. Resulting cells …

Fiber- And Acetate-Mediated Modulation Of Mhc-Ii Expression On Intestinal Epithelium Protects From Clostridioides Difficile Infection, José L Fachi, Tihana Trsan, Silvia Penati, Susan Gilfillan, Siyan Cao, Krzysztof L Hyrc, Xiuli Liu, Patrick Fernandes Rodrigues, Bishan Bhattarai, Marco Colonna, Et Al.

2020-Current year OA Pubs

Here, we explore the relationship between dietary fibers, colonic epithelium major histocompatibility complex class II (MHC-II) expression, and immune cell interactions in regulating susceptibility to Clostridioides difficile infection (CDI). We find that a low-fiber diet increases MHC-II expression in the colonic epithelium, which, in turn, worsens CDI by promoting the development of pathogenic CD4

Effect On Cardiovascular Outcome Of Sodium-Glucose Co-Transporter-2 (Sglt2) Inhibitors Among Cancer Patients Treated With Anthracycline: A Systematic Review And Meta-Analysis, Chalothorn Wannaphut, Phuuwadith Wattanachayakul, Sakditad Saowapa, Ben Ponvilawan, Manasawee Tanariyakul, Jakrin Kewcharoen, Pitchaporn Yingchoncharoen, Thanathip Suenghataiphorn, Noppawit Aiumtrakul, Jared Acoba

Department of Medicine Faculty Papers

Background/objectives: Sodium-glucose-co-transporter-2 (SGLT2) inhibitors have shown benefit in reducing cardiovascular disease outcomes in diabetes patients. Anthracycline therapy is associated with a risk of cardiomyopathy. However, the impact of SGLT2 inhibitors in the prevention of cardiomyopathy and heart failure in cancer patients undergoing anthracycline treatment remains unclear. Thus, we conducted a systematic review and meta-analysis to explore the effect of the prevention of cardiovascular outcomes in patients with cancer and diabetes who had received anthracycline therapy.

Methods: We systematically reviewed Medline and EMBASE databases from inception to January 2024 for studies focusing on cancer patients with a history of anthracycline therapy. …

Designing Patient-Centered Interventions For Emergency Care: Participatory Design Study, Woosuk Seo, Shruti Jain, Vivian Le, Jiaqi Li, Zhan Zhang, Hardeep Singh, Kalyan Pasupathy, Prashant Mahajan, Sun Young Park

Faculty, Staff and Students Publications

Background: Emergency departments (EDs) are high-pressure environments where clinicians diagnose patients under significant constraints, including limited medical histories, severe time pressures, and frequent interruptions. Current ED care practices often inadequately support meaningful patient participation. Most interventions prioritize clinical workflow and health care provider communication, inadvertently overlooking patients' needs. Additionally, patient-facing technologies in EDs are typically developed without meaningful patient input, leading to solutions that may not effectively address patients' specific challenges. To enhance both patient-centered care practices and the diagnosis process in EDs, patient involvement in technology design is essential to ensure their needs during emergency care are understood and …

Xeroderma Pigmentosum: A Review Of Non-Classical Symptoms, Parker Feltner, Noah Schultz, Noah Boekweg, Sameen Kazmi, Jasmeen Sran, Daniel Ramirez, Maycie Mcbride, Mason Chase, Lindsey Humphrey

Annual Research Symposium

Xeroderma pigmentosum (XP), a rare and enigmatic condition, has recently emerged as a focal point in the intersection of dermatology and nucleotide excision repair. Historically, physicians have been primarily concerned the dermatological aspects of classical XP. However, there remains an opaque awareness of the remaining manifestations as they relate to the clinical setting, as well as diagnosis and treatment. We aim to provide a comprehensive overview of the current knowledge regarding the interplay between XP and the symptoms that require further investigation. To that end, we reviewed several studies and evaluated the action key manifestations of XP, aside from dermatological …

Anxiety Reduction In Autism Spectrum Disorder Using Novel Deep-Pressure Cutaneous Stimulation Therapy, Aaron Andrews, Jordyn Huecker, Kennedy Madrid, Lorissa Thorpe, James Fini, Josilyn Zamora, Victoria Oyeniyi, Maura Hart, Amanda Page, James Barber, Chase Taylor, Halah Khan, Spencer Willardson, Kyle Bills Phd, Christina Small

Annual Research Symposium

No abstract provided.

A Literary Review Of Physician Approach To Patient Care: Implications In Cancer Care, Daniel Ramirez, Kinsley Batson

Annual Research Symposium

No abstract provided.

Comparative Evaluation Of Post Treatment Stability During Orthodontic Retention Using Lingual Bonded Retainers Versus Lingual Bonded Retainers Coupled With Thermoformed Retainers – A Randomized Controlled Trial, Meenakshi Jawaharlal, Saravanakumar S, Dharani S

Annual Research Symposium

No abstract provided.

A Nano-Ct Investigation Of Preheated Resin Composites: Effects On Voids, Adaptation, And Polymerization Shrinkage, Venkata Suresh Venkataiah, Rajaram Sundaravarathan, Deepak Mehta, Meena Naganath

Annual Research Symposium

No abstract provided.

Cucumis Melo. L- An Oral Wellness Oasis For The Prevention And Remineralisation Of White Spot Lesions, Gokilla Priya Murugan, Prema Anbarasu, Saravanakumar S, Balaji R

Annual Research Symposium

No abstract provided.

Vialinin A Prevents Lipopolysaccharide-Induced Cytotoxicity Of Human Dermal Fibroblasts, Hou Yuan Huang, Charles Fleischmann, Kota Ramana

Annual Research Symposium

No abstract provided.

Clinical Effectiveness Of Biodentine In Adult Pulpotomy Procedures: A Systematic Review, Aditya Deshpande, Shilpa Bhandi, Shankargouda Patil, Frank W. Licari

Annual Research Symposium

This systematic review aimed to evaluate the evidence from randomised clinical trials for the effectiveness of pulpotomy using Biodentine in adult humans, focusing on clinical outcomes of pain after the procedure and radiographic evaluations.

Mmp-13 Levels In Gingival Crevicular Fluid: A Comparative Study Of Clear Aligners And Fixed Orthodontic Therapy, Ms Ravi, Ishika Sinha, Rasika Kulkarni

Annual Research Symposium

Our study estimated and compared the levels of MMP-13 in Gingival Crevicular Fluid during tooth movement in individuals undergoing orthodontic treatment using clear aligner and conventional fixed MBT brackets.

Enhancing Staff Impact On Medication Adherence In A Mental Health Outpatient Clinic, Uzoamaka Lynda Mbadugha

Walden Dissertations and Doctoral Studies

This Doctor of Nursing Practice project addressed the critical issue of medication nonadherence among mental health patients by implementing a staff education program at an outpatient clinic in the Mid-Atlantic region USA. The program focused on enhancing staff knowledge and confidence through training in psychoeducation, motivational interviewing, and multidisciplinary collaboration. Nonadherence often leads to relapse, hospitalization, and poor outcomes, compounded by a lack of structured interventions at the project site. Sixteen clinic staff members participated in biweekly training sessions over a one-month period. Pre- and post-training assessments revealed a 44.79% increase in staff knowledge and a 50% improvement in confidence …

Is Universal Health Coverage Really Better? Unintended Consequences Of The 2019 Amendment Of The National Health Insurance Act For Humanitarian Sojourners In South Korea, Minji Ju, Minah Kang, Eunice Y. Park

Department of Public Health Scholarship and Creative Works

Background

South Korea achieved universal health coverage (UHC) through the National Health Insurance (NHI). However, humanitarian sojourners under temporary stay permits were initially excluded. Alongside recommendations from the National Human Rights Commission of Korea (NHRCK), the 2019 Amendment of the NHI Act expanded eligibility of the NHI. While this marked significant progress toward greater universality in health care, it also led to unintended consequences for humanitarian sojourners.

Methods

This study employed a two-fold approach aligned with the trajectory of the Amendment. First, we conducted semi-structured in-depth interviews to analyze diverse perspectives on the universality of health coverage, the benefits of …

Promoting Consistency In Phq-9 Depression Screening For Young Adults In An Outpatient Mental Health Clinic., Abena V. Prempeh

Walden Dissertations and Doctoral Studies

This project aimed to improve the consistency of PHQ-9 depression screenings for young adults in an outpatient mental health clinic. Through the implementation of standardized protocols and staff training, the goal was to reduce variability in screening outcomes. The evaluation method of the project involved staff interviews, surveys, and comparing pretest and post-test results to measure staff knowledge and confidence improvements. The results showed that there were significant improvements in staff knowledge and confidence. This project highlights the importance of standardized procedures in improving mental health care for young adults.

Increased Suicidality Risk Among Adolescents With An Active-Duty Sibling Or Parent In The United States, Andrew S. London, Kevin M. Antshel

Population Health Research Brief Series

Adolescents who have a parent currently serving in the U.S. military face distinctive social stressors and developmental challenges, and have higher rates of internalizing and externalizing disorders, substance use, and suicidality than adolescents who do not have an active-duty parent. Additionally, adolescents with siblings who enter the military are at increased risk of experiencing a major depressive episode relative to adolescents who do not have an active-duty sibling. This brief summarizes findings from a study that used data from the 2016-2019 National Survey of Drug Use and Health (NSDUH) to examine whether having a sibling and/or a parent on active …

Mhealth App To Promote Healthy Lifestyles For Diverse Families Living In Rural Areas: Usability Study, Alejandra Perez Ramirez, Adrian Ortega, Natalie Stephenson, Angel Muñoz Osorio, Anne E Kazak, Thao-Ly Phan

Department of Pediatrics Faculty Papers

BACKGROUND: Mobile Integrated Care for Childhood Obesity is a multicomponent intervention for caregivers of young children with obesity from rural communities that was developed in collaboration with community, parent, and health care partners. It includes community programming to promote healthy lifestyles and address social needs and health care visits with an interdisciplinary team. A digital mobile health platform-the Healthy Lifestyle (Nemours Children's Health) dashboard-was designed as a self-management tool for caregivers to use as part of Mobile Integrated Care for Childhood Obesity.

OBJECTIVE: This study aimed to improve the usability of the English and Spanish language versions of the Healthy …

Otolaryngology Practitioner Attitudes Toward Human Papillomavirus Vaccination In Academic Otolaryngology Clinics, Dante J. Merlino, Katelyn S. Rourk, George B. Sankar, Adam J. Luginbuhl, Brian J. Boyce, Michelle M. Chen, Eric M. Dowling, Michael C. Topf, Raymond L. Chai, Karthik Rajasekaran, Eric J. Moore, Daniel L. Price, George Saieed, Kathryn M. Van Abel

Department of Otolaryngology - Head and Neck Surgery Faculty Papers

Despite the existence of a highly effective and safe vaccine against human papillomavirus (HPV) infection, vaccination rates remain low. The most prevalent HPV-associated malignancy in the United States is oropharyngeal cancer, but otolaryngology practitioners do not offer the HPV vaccine, and their feelings around offering HPV vaccination have not been evaluated. A 43-question survey, including a twelve-question knowledge quiz, was sent to otolaryngology practitioners at seven academic institutions. Twelve questions comprised a knowledge quiz testing practitioner understanding of HPV, while the remainder of the questions evaluated comfort with and likelihood of recommending vaccination. Of the 442 practitioners who were sent …

Unm Researcher Studies How Night Shift Work And Artificial Light Affect Human Health, Dustin Roberto

HSC Newsroom

Barbara Harding, PhD, is an epidemiologist & Assistant Professor in the University of New Mexico College of Population Health who studies how night shift work and artificial light at night affect cardiometabolic health. She co-coordinated the EPHOR Night Shift Study, which collects biomarker data from night and day shift workers. According to Harding, night shift workers face greater risk of adverse outcomes from poor sleep, disrupted circadian rhythms and increased social stressors, which may differ by sex; EPHOR looks to assess these relationships by gender, work duration, and history.

Mexiletine Dosing And Tolerability In Refractory Chronic Migraine: Insights From Post-Lidocaine Infusion Treatment, Lucia Liao, Hsiangkuo Yuan, Dylan Selbst, Emily Casaletto, Jiangang Liao, Clinton Lauritsen

Department of Neurology Faculty Papers

Background: Mexiletine is used as a preventive medication for refractory chronic migraine (rCM) and to prolong migraine improvement following intravenous lidocaine infusion. However, published evidence supporting its use in migraine remains limited. This retrospective study describes the dosing, treatment duration, and adverse effects of mexiletine in a group of patients with rCM following lidocaine infusion. Methods: Electronic medical records were reviewed at the Jefferson Headache Center. Baseline pain intensity and monthly headache days were collected at baseline and up to 6 office visits within 1-year post-discharge. The duration of mexiletine treatment was evaluated for up to 40 months post-discharge. Results: …

Surgical Repair Of An Atypical Midsubstance Distal Biceps Tendon Partial Tear: A Case Report, Michael M. Valenzuela, Genoveffa R. Morway, Christopher M. Jones

Department of Orthopaedic Surgery Faculty Papers

No abstract provided.

Thrombocytopenia In Sepsis, Alireza Setarehaseman, Robert W. Maitta

Faculty Scholarship

Platelets, traditionally known for their role in hemostasis, have emerged as key players in immune response and inflammation. Sepsis, a life-threatening condition characterized by systemic inflammation, often presents with thrombocytopenia, which at times, can be significant. Platelets contribute to the inflammatory response by interacting with leukocytes, endothelial cells, and the innate immune system. However, excessive platelet activation and consumption can lead to thrombocytopenia and exacerbate the severity of sepsis. Understanding the multifaceted roles of platelets in sepsis is crucial for developing effective therapeutic strategies. Targeting platelet-mediated inflammatory responses and promoting platelet production may offer potential avenues for improving outcomes in …

Early Childhood Caries And Associated Risk Factors Among Preschool Children In Southeast Iran, Homa Kamyabi, Parisa Kalantari, Azadeh Horri, Fereshteh Abbasi, Mahsa Kalantari

School of Public Health Faculty Publications

Objective: To determine the prevalence of ECC and evaluate its association with possible risk factors in a group of preschool children in Kerman, Iran. Material and Methods: This cross-sectional study was conducted in Kerman on healthy preschool children (up to 6 years old) in June and October 2021. The children were randomly selected from kindergartens using a clustered sampling method, and their height, weight, dental caries, and occlusion were evaluated. Parents completed a questionnaire assessing feeding habits (breast/bottle feeding) and oral habits during the first two years of life. Data were analyzed by logistic regression and chi-squared test using SPSS …

Increasing Covid-19 Testing And Vaccination Uptake In The Take Care Texas Community-Based Randomized Trial: Adaptive Geospatial Analysis, Kehe Zhang, Jocelyn V Hunyadi, Marcia C De Oliveira Otto, Miryoung Lee, Zitong Zhang, Ryan Ramphul, Jose-Miguel Yamal, Ashraf Yaseen, Alanna C Morrison, Shreela Sharma, Mohammad Hossein Rahbar, Xu Zhang, Stephen Linder, Dritana Marko, Rachel White Roy, Deborah Banerjee, Esmeralda Guajardo, Michelle Crum, Belinda Reininger, Maria E Fernandez, Cici Bauer

Faculty, Staff and Student Publications

BACKGROUND: Geospatial data science can be a powerful tool to aid the design, reach, efficiency, and impact of community-based intervention trials. The project titled Take Care Texas aims to develop and test an adaptive, multilevel, community-based intervention to increase COVID-19 testing and vaccination uptake among vulnerable populations in 3 Texas regions: Harris County, Cameron County, and Northeast Texas.

OBJECTIVE: We aimed to develop a novel procedure for adaptive selections of census block groups (CBGs) to include in the community-based randomized trial for the Take Care Texas project.

METHODS: CBG selection was conducted across 3 Texas regions over a 17-month period …