Medicine and Health Sciences Commons^™

Early Achievement Of Hemostasis Defined By Transfusion Velocity: A Possible Mechanism For Whole Blood Survival Benefit, Amanda M Chipman, James F Luther, Francis X Guyette, Bryan A Cotton, Jeremy W Cannon, Martin A Schreiber, Ernest E Moore, Nicholas Namias, Joseph P Minei, Mark H Yazer, Laura Vincent, Abigail L Cotton, Vikas Agarwal, Joshua B Brown, Christine M Leeper, Matthew D Neal, Raquel M Forsythe, Stephen R Wisniewski, Jason L Sperry, Swat Study Group

Faculty, Staff and Student Publications

Introduction: Whole blood resuscitation is associated with survival benefits in observational cohort studies. The mechanisms responsible for outcome benefits have not been adequately determined. We sought to characterize the achievement of hemostasis across patients receiving early whole blood versus component resuscitation. We hypothesized that achieving hemostasis would be associated with outcome benefits and patients receiving whole blood would be more likely to achieve hemostasis.

Methods: We performed a post hoc retrospective secondary analysis of data from a recent prospective observational cohort study comparing early whole blood and component resuscitation in patients at risk of hemorrhagic shock. Achievement of hemostasis was …

Launching! To Adulthood: An Updated Group Therapy Program For Young Adults With Neurodevelopmental Differences Transitioning To Adulthood, Antonio F Pagán, Katherine A Loveland

Faculty, Staff and Student Publications

Objectives: The transition to adulthood is a formative period of development for young adults, as they work towards independence and managing adult responsibilities. This time can be especially difficult for young adults with neurodevelopmental disorders (NDDs; such as autism spectrum disorder [ASD] or attention-deficit/hyperactivity disorder [ADHD]), who may experience executive functioning and social communication difficulties. Parents also may experience an increased burden during this transition. However, evidence-based interventions for young adults with NDDs rarely integrate parents. The present study provided initial feasibility and acceptability data for a therapy program for young adults with NDDs transitioning to adulthood and their parents. …

Bilateral Macronodular Adrenocortical Disease: A Single Centre Experience, Anuj Ban, Rohit Barnabas, Manjiri Karlekar, Anurag Ranjan Lila, Chethan Yami Channaiah, Saba Samad Memon, Virendra A Patil, Vijaya Sarathi, Gwendolyn Fernandes, Hemangini Thakkar, Sameer Rege, Nalini S Shah, Tushar Bandgar

Faculty, Staff and Student Publications

Background: Data on bilateral macronodular adrenocortical disease (BMAD) with respect to computed tomography (CT) scan characteristics (attenuation and washout) and long-term follow-up are limited. This study aims to describe BMAD patients managed in a single centre.

Methods: BMAD was defined by the presence of bilateral adrenal macronodules (>1 cm) on CT. Clinical, biochemical, radiological, genetic characteristics, management and follow-up of 22 BMAD patients were studied retrospectively.

Results: The median age (range) at presentation was 49.5 (23-83) years, predominantly observed in females (16/22). Eighteen (82%) patients were incidentally diagnosed (11 with mild autonomous cortisol secretion (MACS) and seven non-secretory), three …

Open-Hybrid Aortic Stent Placement For Recurrent Coarctation In Complex Single Ventricles, Andrew K Morse, Blaz Podgorsek, Julija Dobrila, Zachary A Cerra, Kiran K Mallula, Muhammad S Khan, Christopher E Greenleaf, Jorge D Salazar, Damien J Lapar, Peter C Chen

Faculty, Staff and Student Publications

Recurrent coarctation of the aorta in patients with hypoplastic left heart syndrome requires timely intervention to limit ventricular dysfunction and atrioventricular valve regurgitation. Current strategies include catheter-based intervention in adequately sized patients or surgical arch augmentation at the time of a concomitant operation. We report an open-hybrid surgical technique with placement of a balloon-expandable stent that can later be expanded to an adult size as the patient grows. Limiting the arch dissection reduces the risk to the left recurrent laryngeal nerve and shortens anterograde cerebral perfusion time.

Temperature-Controlled Radiofrequency Treatment Of The Nasal Valve In Nasal Airway Obstruction Patients With Septal Deviation, Dennis M Tang, Philip G Chen, Arthur W Wu, William C Yao

Faculty, Staff and Student Publications

Nasal valve treatment with TCRF results in NAO symptom improvement in the presence of septal deviation. Severe septal deviation does not impact the beneficial effect of TCRF nasal valve treatment. Symptoms improve with TCRF nasal valve treatment even if septal deviations involve the nasal valve.

The Vivid Trial 12-Month Outcomes Of The Venous Stent For The Iliofemoral Vein Using The Duo Venous Stent System., Mahmood Razavi, Michael Lichtenberg, Kush Desai, David Dexter, Peter Soukas, Nicolas Shammas, Ankur Lodha, Paul Gagne, Anna Nordell, Raghu Kolluri, Mark Garcia

Heart and Vascular Articles

OBJECTIVE: There are varying anatomical and mechanical demands of stent placement in the iliofemoral venous segment; the Duo Venous Stent System is designed to address these issues. The purpose of the VIVID (Venous stent for the Iliofemoral Vein Investigational clinical trial using the Duo Venous Stent System) study was to investigate the safety and efficacy of the Duo Venous Stent System for the treatment of patients with nonmalignant iliofemoral venous obstructive disease.

METHODS: This was an international, prospective, multicenter, single-arm study that enrolled patients with symptomatic nonthrombotic (NT), post-thrombotic (PTS), or acute deep vein thrombotic (aDVT) iliofemoral venous outflow obstruction. …

The Associations Of Sensory Impairment With 10-Year Risk Of Dementia And Alzheimer's Disease: The Health And Retirement Study, 2010-2020, Kun Li, Rahul Ghosal, Donglan Zhang, Yike Li, Matthew C Lohman, Monique J Brown, Anwar T Merchant, Chih-Hsiang Yang, Jean Neils-Strunjas, Daniela B Friedman, Jingkai Wei

Faculty, Staff and Student Publications

Background: Studies have examined the association between dual sensory impairment and late-life cognitive outcomes in the U.S with inconsistent findings.

Objective: To examine the associations between sensory impairment and 10-year risk of dementia or Alzheimer's disease among U.S. adults aged ≥ 50.

Methods: A prospective cohort study based on the Health and Retirement Study from 2010 to 2020. Individuals aged ≥ 50 years without self-reported dementia and Alzheimer's disease in 2010 were included in the analysis. Self-reported visual and hearing impairments were measures in 2010. Main failure events included self-reported incident dementia and Alzheimer's disease over a 10-year follow-up period. …

Depletion Of Acetyl-Coa Carboxylase 1 Facilitates Epithelial-Mesenchymal Transition In Prostate Cancer Cells By Activating The Mapk/Erk Pathway, Jiarun Lai, Shaoyou Liu, Yupeng Chen, Jian Chen, Jinchuang Li, Zhenguo Liang, Xinyue Mei, Yuanfa Feng, Zhaodong Han, Funeng Jiang, Shengbang Yang, Yongding Wu, Huijing Tan, Junchen Liu, Huichan He, Weide Zhong

Faculty, Staff and Student Publications

Hyperactivation of fatty acid biosynthesis holds promise as a targeted therapeutic strategy in prostate cancer (PCa). However, inhibiting these enzymes could potentially promote metastatic progression in various other cancers. Herein, we found that depletion of acetyl-CoA carboxylase 1 (encoded by ACACA), the enzyme responsible for the first and rate-limiting step of de novo fatty acid biosynthesis, facilitated epithelial-mesenchymal transition (EMT) and migration of PCa cells. This finding was validated in vitro through cell migration assays and in vivo using a metastatic model established by tail vein injection of ACACA-depleted cells into BALB/c nude mice. Additionally, depletion of ACACA activated the …

Oxidized Carbon Nanoparticles Enhance Cellular Energetics With Application To Injured Brain, Karthik Mouli, Anton V Liopo, Emily A Mchugh, Erica Underwood, Jing Zhao, Pramod K Dash, Anh T T Vo, Vikas H Malojirao, Muralidhar L Hegde, James M Tour, Paul J Derry, Thomas A Kent

Faculty, Staff and Student Publications

Pro-energetic effects of functionalized, oxidized carbon nanozymes (OCNs) are reported. OCNs, derived from harsh acid oxidation of single-wall carbon nanotubes or activated charcoal are previously shown to possess multiple nanozymatic activities including mimicking superoxide dismutase and catalyzing the oxidation of reduced nicotinamide adenine dinucleotide (NADH) to NAD+. These actions are predicted to generate a glycolytic shift and enhance mitochondrial energetics under impaired conditions. Impaired mitochondrial energy metabolism is increasingly recognized as an important facet of traumatic brain injury (TBI) pathophysiology and decreases the efficiency of electron transport chain (ETC)-coupled adenosine triphosphate (ATP) and NAD+ regeneration. In vitro, OCNs promote a …

Endovascular Therapy In Patients With Acute Ischemic Stroke With Large Infarct: A Guideline From The Society Of Vascular And Interventional Neurology, Maxim Mokin, Tudor G Jovin, Sunil A Sheth, Thanh N Nguyen, Kaiz S Asif, Ameer E Hassan, Ashutosh P Jadhav, Cynthia Kenmuir, David S Liebeskind, Ossama Mansour, Raul G Nogueira, Robin Novakovic, Santiago Ortega-Gutierrez, Albert J Yoo, Waldo R Guerrero, Amer M Malik

Faculty, Staff and Student Publications

Background: Recent randomized clinical trials of endovascular therapy in patients with large infarct provided new evidence in support of endovascular interventions in patients with acute ischemic stroke. The Society of Vascular and Interventional Neurology Guidelines and Practice Standards committee aims to provide up-to-date recommendations on focused relevant clinical questions. Here, we review current evidence and provide recommendations for the selection and endovascular treatment of patients with anterior circulation large vessel occlusion and large infarct.

Methods: The Society of Vascular and Interventional Neurology Guidelines and Practice Standards committee assembled a writing group and recruited interdisciplinary experts to review and evaluate the …

Nulliparous With Class Iii Obesity At Term: Labor Induction Or Cesarean Delivery Without Labor, Yossi Bart, Rachel L Wiley, Ipsita Ghose, Michal Fishel Bartal, Khalil M Chahine, Suneet P Chauhan, Sean Blackwell, Baha M Sibai

Faculty, Staff and Student Publications

Objective: This study aimed to compare maternal and neonatal outcomes between labor induction versus cesarean delivery (CD) without labor among nulliparous individuals with class III obesity (body mass index [BMI] ≥40 kg/m2).

Study design: A retrospective cohort study of all nulliparous singleton deliveries at ≥37 weeks with a BMI of ≥40 kg/m2 at delivery between March 2020 and February 2022. We excluded individuals with spontaneous labor, fetal malformations, and stillbirths. The primary outcome was a composite of maternal mortality and morbidity, including infectious and hemorrhagic morbidity. The secondary outcome was a neonatal composite. A subgroup analysis evaluated patients with a …

Intra- And Postoperative Complications In 4565 Vnotes Hysterectomies: International Registry Cohort Study., Andrea Stuart, Johanna Wagenius, Levon Badiglian-Filho, Jens Schnabel, Alvaro Montealegre, Sophia Ehrström, Michael Hartmann, Jona Vercammen, Daniela Huber, Anna Lingström, Jan Baekelandt

Faculty, Staff and Student Publications

Objective: To present the rates of intra- and postoperative complications and conversions in a large cohort of unselected vNOTES hysterectomies, performed by surgeons with different levels of expertise.

Design: International register-based cohort study.

Setting: Hysterectomies in the iNOTESs registry, 2015 to January 2024, performed by 201 surgeons from multiple countries.

Population: 4565 patients undergoing vNOTES hysterectomy.

Methods: Descriptive data are presented in frequencies (n) and percent (%).

Main outcome measure: Intra- and postoperative complications. Conversions.

Results: Intraoperative and postoperative complication rates were 3.2% (n = 144) and 2.5% (n = 115), respectively. Conversions occurred in 1.6% (n = 72), of …

Curq+ With Resveratrol Diminish Joint Pain In A Child With Pseudoachondroplasia: A Case Report, Jacqueline T Hecht, Ana-Coral Barreda-Bonis, Karen L Posey

Faculty, Staff and Student Publications

This case report details the successful use of over-the-counter resveratrol and CurQ+ in a five-year-old with pseudoachondroplasia (PSACH), a severe dwarfing condition caused by mutations in cartilage oligomeric matrix protein (COMP). Disproportionate short stature, abnormal joints, joint deformities, and pain starting in early childhood are characteristic findings. Adult treatments include non-steroidal anti-inflammatory drugs (NSAIDs) and joint replacement to manage joint pain. Childhood pain goes largely untreated given the concern of daily use of NSAIDs in the very young. Recently, resveratrol has been shown to reduce pain and CurQ+ improves growth in a mouse model of PSACH. The use of these …

Liver Involvement In A Large Cohort Of Patients With Erythropoietic Protoporphyria Or X-Linked Protoporphyria, Cynthia Levy, Hetanshi Naik, Jessica Overbey, Karli Hedstrom, Kelly Wang, Catherine Mcdonough, Mary Freeman, Siobán B Keel, Angelika L Erwin, Amy K Dickey, Rebecca K Leaf, John Quigley, Marshall Mazepa, Bruce Wang, John Phillips, Charles Parker, Brendan Mcguire, Mohamed Kazamel, Herbert Bonkovsky, Sean Rudnick, Karl E Anderson, Akshata Moghe, Manish Thapar, Behnam Saberi, Kristen Wheeden, Robert Desnick, Manisha Balwani, Porphyrias Consortium Of The Rare Diseases Clinical Research Network

Faculty, Staff and Student Publications

Background: Erythropoietic protoporphyria (EPP) and X-linked protoporphyria (XLP) are characterized by the accumulation of protoporphyrin in the marrow, erythrocytes, plasma, skin, and liver, and present clinically with painful cutaneous phototoxicity. Liver abnormalities have been reported in over 25% of patients with EPP. Further characterization of liver involvement in protoporphyria is needed.

Methods: Patients with EPP or XLP enrolled in the longitudinal studies of the NIH-supported Porphyrias Consortium were included. Medical history, laboratory, and liver histology data were abstracted and described.

Results: A total of 322 patients were enrolled; 28 (8.7%) had XLP, 52% were female, and the median age at …

Assessment Of Skin Fibrosis In A Murine Model Of Systemic Sclerosis With Multifunctional Optical Coherence Tomography, Harshdeep Singh Chawla, Yanping Chen, Minghua Wu, Pavel Nikitin, Jessica Gutierrez, Chandra Mohan, Manmohan Singh, Salavat R Aglyamov, Shervin Assassi, Kirill V Larin

Faculty, Staff and Student Publications

Significance: Systemic sclerosis (SSc) is a chronic idiopathic disease that causes immune dysregulation, vasculopathy, and organ fibrosis that affects more than 3 million people in the US alone. The modified Rodnan skin score (mRSS) is the current gold standard for diagnosing and staging skin fibrosis in SSc. However, mRSS is subjective, requires extensive training, and has high observer variability.

Aim: We aim to provide a quantitative method for the assessment of fibrosis.

Approach: We utilized optical coherence tomography (OCT), its extensions, optical coherence elastography (OCE), and OCT angiography (OCTA) to evaluate SSc-like fibrosis and therapy response in a mouse model. …

Relapsed Acute Myeloid Leukemia With Early Presentation As Leukemia Cutis, Refractory To Second-Line Treatment, Emin Gayibov, Aditi Karambelkar, Virushnee Senthilkumar, Amita J Dsouza, Amit K Correa

Faculty, Staff and Student Publications

Acute myeloid leukemia (AML) is a hematologic malignancy with a poor prognosis, often presenting with systemic and extramedullary manifestations. Leukemia cutis (LC), the infiltration of leukemic cells into the skin, is a rare and clinically significant complication of AML. It often signals extramedullary disease involvement, may precede systemic relapse, and is associated with poor survival outcomes. We report the case of a 36-year-old female with AML who developed recurrent, reddish-brown nodular skin lesions on the face, trunk, and extremities, consistent with LC. Despite achieving initial remission with induction and consolidation chemotherapy, she experienced early LC recurrence, pancytopenia, hepatobiliary dysfunction, and …

Midwives Experience Of Working With Maternity Assistants: A Qualitative Study, Carol Crevacore, Annie De Leo, Peta Fisher, Sara Bayes

Research outputs 2022 to 2026

Introduction: The midwifery workforce is essential for delivering safe, high-quality maternity care, however, global staffing shortages pose significant challenges. To address these issues, incorporating midwifery assistants, including undergraduate midwifery students into the model of care has been proposed as a strategy to support midwives and maintain effective service delivery. Aim: This study explores the Registered Midwives' experiences working with Midwifery Assistants (MAs) in an Australian tertiary maternity service. Methods: This study employed a qualitative exploratory design and was conducted using semi-structured interviews with 9 midwives who had experienced working with MAs in the tertiary maternity care setting. Results: The discussion …

Pulmonary Nodule Malignancy Probability: A Meta-Analysis Of The Brock Model, S. Chen, W. L. Lin, W. T. Liu, L. Y. Zou, Y. Chen, F. Lu

Research outputs 2022 to 2026

Aim: This study aims to quantify the performance of the Brock model through a systematic review and meta-analysis and to clarify its overall accuracy in predicting malignant pulmonary nodules. Materials and Methods: A systematic search was conducted in databases including the Cochrane Library, Excerpta Medica database (EMBASE), MEDLINE, Web of Science, Chinese Biological Medicine Database (CBM), China National Knowledge Infrastructure (CNKI), VIP, and Wanfang from their inception until May 1, 2024, to collect observational cohort studies involving the Brock model. The primary outcome was the pooled area under the receiver operating characteristic curve (ROC) the area under curve (AUC) for …

The Evolving Role Of Nursing Informatics In The Era Of Artificial Intelligence, Abdulqadir J. Nashwan, J. C.A. Cabrega, Mutaz I. Othman, Mahmoud Abdelwahab Khedr, Yasmine M. Osman, Ayman Mohamed El-Ashry, Rami Naif, Ahmad A. Mousa

Research outputs 2022 to 2026

Aim: This narrative review explores the integration of artificial intelligence (AI) into nursing informatics and examines its impact on nursing practice, healthcare delivery, education, and policy. Background: Nursing informatics, which merges nursing science with information management and communication technologies, is crucial in modern healthcare. The emergence of AI presents opportunities to improve diagnostics, treatment, and healthcare resource management. However, integrating AI into nursing practice also brings challenges, including ethical concerns and the need for specialized training. Sources of evidence: A comprehensive literature search was conducted from January 2013 to December 2023 using databases like PubMed, Google Scholar, and Scopus. Articles …

Genomic Characterisation Of The Relationship And Causal Links Between Vascular Calcification, Alzheimer’S Disease, And Cognitive Traits, Emmanuel O. Adewuyi, Simon M. Laws

Research outputs 2022 to 2026

Background/Objectives: Observational studies suggest a link between vascular calcification and dementia or cognitive decline, but the evidence is conflicting, and the underlying mechanisms are unclear. Here, we investigate the shared genetic and causal relationships of vascular calcification—coronary artery calcification (CAC) and abdominal aortic calcification (AAC)—with Alzheimer’s disease (AD), and five cognitive traits. Methods: We analyse large-scale genome-wide association studies (GWAS) summary statistics, using well-regarded methods, including linkage disequilibrium score regression (LDSC), Mendelian randomisation (MR), pairwise GWAS (GWAS-PW), and gene-based association analysis. Results: Our findings reveal a nominally significant positive genome-wide genetic correlation between CAC and AD, which becomes non-significant after …

Patterns Of Dietary Fatty Acids And Fat Spreads In Relation To Blood Pressure, Lipids And Insulin Resistance In Young Adults: A Repeat Cross-Sectional Study, Richard Woodman, Arduino A. Mangoni, Sarah Cohen-Woods, Trevor A. Mori, Lawrence Beilin, Karen Murphy, Jonathan Hodgson

Research outputs 2022 to 2026

Background/Objectives: Determining whether dietary fatty acids and the use of fat spreads are associated with cardiovascular risk factors is difficult due to the multicollinearity of fatty acids and the consumption of multiple spread types. Methods: We applied clustering methodologies using data on 31 different fatty acids and 5 different types of fat spreads (high fat: butter, blended butters, and margarines; lower fat: polyunsaturated and monounsaturated) and investigated associations with blood pressure, serum lipid patterns and insulin resistance in the Raine Study Gen2 participants in Western Australia, at 20 and 22 years of age. Results: Amongst n = 785 participants, there …

Acknowledging: A Classic Grounded Theory Explaining How Nurses' Employ Clinical Judgement When Complying With Early Warning System Protocols, Justine Connor, Tracy Flenady, Trudy Dwyer, Deb Massey

Research outputs 2022 to 2026

Background: Recognition and response to clinical deterioration of hospitalised patients is a worldwide health priority area. In response to this concern, international bodies have implemented early warning systems to help clinicians keep people safe and prevent patient deterioration. Registered nurses hold a significant role in managing care provision and utilise early warning system tools to support their clinical judgement when making decisions about patient care. Objective: To generate a theory explaining how registered nurses employ their clinical judgement when complying with an early warning system protocol. Design: Classic grounded theory. Participants: Participants included twenty registered nurses working with early warning …

Automated Abdominal Aortic Calcification And Major Adverse Cardiovascular Events In People Undergoing Osteoporosis Screening: The Manitoba Bone Mineral Density Registry, Cassandra Smith, Marc Sim, Zaid Ilyas, Syed Zulqarnain Gilani, David Suter, Siobhan Reid, Barret A. Monchka, Mohammed Jafari Jozani, Gemma Figtree, John T. Schousboe, Joshua R. Lewis, William D. Leslie

Research outputs 2022 to 2026

Vertebral fracture assessment (VFA) images from bone density machines enable the automated machine learning assessment of abdominal aortic calcification (ML-AAC), a marker of cardiovascular disease (CVD) risk. The objective of this study was to describe the risk of a major adverse cardiovascular event (MACE, from linked health records) in patients attending routine bone mineral density (BMD) testing and meeting specific criteria based on age, BMD, height loss, or glucocorticoid use have a VFA in the Manitoba BMD Registry. The cohort included 10 250 individuals (mean age 75.5 yr, 94% women without CVD) with VFA (February 2010 to March 2017). ML-AAC24 …

Effects On Force, Velocity, Power, And Muscle Activation Of Resistances With Variable Inertia Generated By Programmable Electromechanical Motors During Explosive Chest Press Exercises, Luca Zoffoli, Silvano Zanuso, Andrea Biscarini

Research outputs 2022 to 2026

Strength training machines incorporating advanced electro-mechanical technologies can produce hybrid resistances with variable inertia, such as a resistance that progressively changes from gravitational (inertial) to pneumatic (non-inertial) across the range of motion (ROM). To explore the biomechanical effects of these innovative resistances, a robotic chest press machine was programmed to offer three distinct inertial profiles: gravitational-type constant inertia throughout the ROM (IFULL); no inertia (IZERO); and linearly descending inertia across the ROM (IVAR). Ten healthy adults performed five maximal-effort, explosive chest press movements under each inertial profile at 30, 50 and 70% of their one-repetition maximum. During each trial, muscle …

Thorium Bioassay Of Miners Revisited, Gregory Hewson, Martin Ralph, Marcus Cattani

Research outputs 2022 to 2026

This study aimed to revisit previous in-vitro thorium studies on workers and reevaluate their significance against the current International Commission on Radiological Protection (ICRP) models for thorium intake. Thorium concentrations in the urine and blood serum of Western Australian mineral sands workers had previously been interpreted using biokinetic models recommended by the ICRP. These findings revealed significant inconsistencies with those of other monitoring methods, including in-vivo lung counting and personal air sampling. Data on thorium concentrations in the urine and blood serum of workers and their exposure records were extracted from the previously published research and assessed using the Taurus …

Healthcare Systems-Based Exercise Oncology Programs: Emphasizing And Speaking The Language Of The Clinic And Patient, Jessica S. Gorzelitz, Mary A. Kennedy, Kim Dittus, Sami Mansfield, Karen Wonders, Pamela A. Hansen, Adriana M. Coletta, Neil M. Iyengar, Kelley Covington Wood, Anna L. Schwartz, Melanie Potiaumpai, Anna Campbell, Kathryn H. Schmitz

Research outputs 2022 to 2026

Introduction Exercise oncology services are evidence based and aim to reduce symptom burden and potentially improve outcomes in adults living with and beyond cancer. Healthcare system-based exercise oncology programs include exercise prior to, during, and after treatment, but the implementation and maintenance of these programs are not well documented. We aimed to describe five healthcare system-based exercise oncology programs in the United States, including service information and barriers to and facilitators of program success. Methods This was a qualitative case study of five healthcare-based exercise oncology programs in the United States informed by the Exploration, Preparation, Implementation, Sustainment framework. We …

Effects Of Hiit In Cool And Hot On Temperate Performance And Physiological Response In Trained Cyclists, Jason R. Boynton, Jeremiah J. Peiffer, Chris R. Abbiss

Research outputs 2022 to 2026

This study investigated cardiopulmonary responses in hot and cool high-intensity interval training (HIIT) and the subsequent effects on time-trial (TT) performance and physiological responses in temperate conditions. Twenty trained cyclists were separated into 2 groups and completed a 4-week HIIT intervention (8 sessions, 5 × 4 minute) at an environmental temperature (TA) of either 13° C (HIIT13) or 35° C (HIIT35). Cardiorespiratory data (e.g., heart rate [HR] and time above 90% Vo2max [T > 90% Vo2max]) were assessed for the first and last interval sessions. Infjects completed 20 km TTs in temperate conditions (22° C) before (TT1) and after (TT2) HIIT …

Implementing A Nurse-Enabled, Integrated, Shared-Care Model Involving Specialists And General Practitioners In Early Breast Cancer Post-Treatment Follow-Up (Eminent): A Single-Centre, Open-Label, Phase 2, Parallel-Group, Pilot, Randomised, Controlled Trial, Raymond J. Chan, Fiona Crawford-Williams, Chad Yixian Han, Lee Jones, Alexandre Chan, Daniel Mckavanagh, Marissa Ryan, Christine Carrington, Rebecca L. Packer, Megan Crichton, Nicolas H. Hart, Emma Mckinnell, Melissa Gosper, Juanita Ryan, Bethany Crowe, Ria Joseph, Carolyn Ee, Jane Lee, Steven M. Mcphail, Katharine Cuff, Laisa Teleni, Jon Emery

Research outputs 2022 to 2026

Background: Current models of post-treatment cancer care rely heavily on hospital-based, medical specialists and do not sufficiently leverage primary care. Many breast cancer survivors face ongoing unmet needs that may benefit from a multidisciplinary, shared-care approach. We aimed to evaluate the feasibility and preliminary effectiveness of implementing nurse-enabled, shared-follow-up care between the acute and primary care setting for early-stage breast cancer. Methods: In this single-centre, open-label, phase II, pilot, randomised, controlled trial, individuals diagnosed with breast cancer (Stage 0–III) were randomised 1:1 to either usual care or intervention, which includes a 1) Specialist Nurse Consultation to co-develop a survivorship care …

Is It Underestimated Or Overestimated?, Zhuoqiao He, Xuerui Tan

Research outputs 2022 to 2026

No abstract provided.

Sedentary Leisure Behaviour, Physical Activity, And Gastroesophageal Reflux Disease: Evidence From A Mendelian Randomization Analysis, Shan Lu, Yahong Zhu, Mingyu Cui, Zheng Guo, Xingang Li, Ying Song

Research outputs 2022 to 2026

Background and Aims: Gastroesophageal reflux disease (GERD) is common worldwide. Although associations between sedentary behaviour (LSBs), physical activity (PAs), and GERD have been reported, their causal relationships remain unclear. This study uses Mendelian randomization (MR) to examine these associations with GERD. Methods: Genetic instruments from the UK Biobank and other consortia were utilized to assess the causal relationship between LSBs, PAs, and GERD. Causal analyses employed inverse variance weighted (IVW), weighted-median (WM), and MR-Egger regression. Sensitivity analyses included Cochran's Q test, MR-Egger intercept test, leave-one-out analysis, and funnel plot assessment. Outliers were detected using MR-PRESSO and Radial MR. A risk …