Medicine and Health Sciences Commons^™

Characterizing Genetic, Epigenetic, Nutritional, And Clinico-Biochemical Profile Of Women With Polycystic Ovary Syndrome: A Case-Control Study, Woroud M. Majd Chaker, Raghda Mohammed Adi, Mohamed Madkour, Nada Farhat, Dana N. Abdelrahim, Maha Saber-Ayad, Jibran Sualeh Muhammad, Ghada Mohammed, Noha Ahmed Mousa, Ameenah Saadi, Arathy Lakshmi, Mai Kazim, Nagla Elhadi Abdalla, Nariman Awad, Fatme Al Anouti, Moezalislam E. Faris

All Works

Objectives: Polycystic ovary syndrome (PCOS) is among the most frequently encountered endocrinopathies in women. This study aimed to characterize the genetic (INSR, FTO, DENND1A, and Nrf2) expressions and epigenetic (DNA methylation) modifications, nutritional, metabolic, inflammatory, and hormonal markers for patients with PCOS in comparison with their age-matched healthy controls. Design & Methods: The study also aimed to assess the genetic expressions concerning vitamin D status. Sixty-six patients with PCOS and 69 age-matched healthy controls were recruited. Fasting blood samples were used to measure genetic and biochemical variables. Real-time PCR was used to assess gene expressions, the bisulfite conversion method was …

Assessing The Impact Of The First Feeding Practice On Wasting Risk Among Indonesian Children Under The Age Of Five, Azrimaidaliza Azrimaidaliza, Annisa Dwi Apriliani, Mutiara Tirta Prabandari Lintang Kusuma

Kesmas

The problem of undernutrition among children under the age of five (the under-five) continues to be alarmingly high in Indonesia, including in West Sumatra Province. Various factors contribute to this issue, with studies suggesting a relationship between intergenerational causes and undernutrition. This study analyzed the main risk factors of wasting among children in Padang City. Data were collected from 174 under-five and divided into unmatched cases that were selected randomly and control groups. The mothers were interviewed using a questionnaire regarding their children’s feeding habits, and weight and height data were collected from primary health care. Multiple logistic regression analysis …

Factors Associated With Caregivers' Concern In Maintaining The Oral Function Of Elderly Living In Long-Term Care Facilities, Susiana Nugraha, Tri Budi Wahyuni Rahardjo, Misako Higashijima, Yuko Hirano

Kesmas

This study investigated the attentiveness of elderly caregivers in long-term care facilities in maintaining oral function. A cross-sectional approach was used to achieve the study's purpose. The sample size formula accounted for 213 caregivers randomly selected from 18 long-term care facilities in 4 provinces. A self-reported questionnaire of sociodemographic characteristics and an adapted Leopold’s oral care checklist was distributed. The average age of study participants was 35.24 (±11.2 SD; aged 18–70 years), dominated by females (62.9%), and only 39% had experienced long-term care training. Multiple linear regression analysis indicated that younger caregivers likely pay more attention in the swallowing periods …

Risk Factors Associated With Long Covid Among Hospitalized Adults In Several Hospitals In Palembang City, Indonesia, Hotma Martogi Lorensi Hutapea, Mondastri Korib Sudaryo, Arli Aditya Parikesit, Tri Yunis Miko Wahyono, Nelda Aprilia Salim

Kesmas

Long COVID is characterized by one or more symptoms experienced by individuals prior to a COVID-19 infection that last for ≥2 months, and its risk factors remain unclear. This study aimed to identify risk factors associated with long COVID among patients admitted between June 1, 2020, and October 31, 2023, at three referral COVID-19 hospitals in Palembang City, Indonesia. This cohort study included adults who were admitted for ≥5 days. The participant’s medical records were reviewed for admission and discharge dates, sociodemographic and clinical characteristics, and vaccination and therapy status. A standardized and validated instrument was used to assess fatigue …

Food Hygiene And Sanitation Of The University Canteens In South Sumatra Province, Indonesia, Anita Rahmiwati, Fatmalina Febry, Fenny Etrawati, Indah Purnama Sari, Yeni Yeni, Virgina Putri Sabila, Erike Septa Prautami, Maretalinia Maretalinia

Kesmas

Food safety is a critical public health issue, especially in institutional settings such as university canteens, where large populations are served daily. Inadequate hygiene and sanitation practices by food handlers can lead to foodborne illnesses, placing students and staff at risk. This study evaluated hygiene and sanitation conditions in the canteens of a leading public university in South Sumatra Province, Indonesia, known for its active food service facilities. This study examined food handlers’ knowledge, attitudes, and practices and assessed the microbiological safety of chicken curry by testing for Escherichia coli (E. coli) contamination and total plate count. Using a cross-sectional …

Machine Learning For Preeclampsia Prediction: Enhancing Screening In Primary Health Care, Dwirani Amelia, Asri Adisasmita, Kemal N. Siregar, Detty Siti Nurdiati

Kesmas

Preeclampsia is a leading cause of maternal morbidity and mortality worldwide, with early detection being critical for reducing adverse outcomes. This study aimed to develop a machine learning model for predicting the risk of preeclampsia using readily available maternal characteristics such as body mass index, mean arterial pressure, and clinical history of hypertension or diabetes mellitus. Secondary data from 2,250 pregnancies were analyzed, addressing challenges such as missing data and class imbalance through preprocessing. Various algorithms, including support vector machines, random forest, and logistic regression, were evaluated. Herein, a support vector machines model with threshold adjustment showed the best performance, …

Availability And Distribution Of Stoma Bags For Colorectal Cancer Patients: A Case Study At National Referral And Private Hospitals, Ratna Aryani, Toar Jm Lalisang, Debie Dahlia, Evi Martha, Achir Yani S Hamid, Sukma Wicaturatmashudi, Helen Helen

Kesmas

Stoma bags are essential for colorectal cancer (CRC) patients with stomas. However, access and affordability in Indonesia remain challenging as the National Health Insurance (NHI) does not fully cover these devices. This study aimed to describe the availability and distribution of stoma bags for patients with CRC in national referral and private hospitals, focusing on outpatient access. A qualitative case study was conducted through observations and in-depth interviews with four enterostomal therapy nurses and six patients across three national referral hospitals and one private hospital in the Jakarta Metropolitan Area, Indonesia. Notably, the availability of stoma bags was limited in …

Development Of Audiovisual Media For Reproductive Health Education For Parents Of Adolescents, Tanjung Anitasari Indah Kusumaningrum, Nurul Latifatul Inayati, Setia Asyanti, Ayu Khoirotul Umaroh, Wardhatul Livia, Ramadani Nur Laili, Trijaya Trijaya, Ririn Cahya Dewanti, Yuli Kusumawati, Izzatul Arifah

Kesmas

Parents are the primary source of information for adolescents, but many parents lack an understanding of health materials. For knowledge to be increased, health media, one of which is audiovisual media, are desirable. This study aimed to develop audiovisual media on adolescents’ reproductive health. Media development utilized the analyze, design, develop, implement, and evaluate (ADDIE) model. The respondents in this study were parents of adolescents aged 10–14 years, comprising 10 parents in the small group evaluation, 20 in the field evaluation, and 10 in the implementation stage. The effectiveness of the media was tested through pretests and posttests. Using a …

Development And Validation Of The Immune Profile Score (Ips), A Novel Multiomic Algorithmic Assay For Stratifying Outcomes In A Real-World Cohort Of Patients With Advanced Solid Cancer Treated With Immune Checkpoint Inhibitors, Alia D Zander, Douglas Adkins, Et Al.

2020-Current year OA Pubs

BACKGROUND: Immune checkpoint inhibitors (ICIs) have transformed the oncology treatment landscape. Despite substantial improvements for some patients, the majority do not benefit from ICIs, indicating a need for predictive biomarkers to better inform treatment decisions.

METHODS: A de-identified pan-cancer cohort from the Tempus multimodal real-world database was used for the development and validation of the Immune Profile Score (IPS) algorithm leveraging Tempus xT (648 gene DNA panel) and xR (RNA sequencing) (N=1,707 development cohort; N=1,600 validation cohort). The cohort consisted of patients with advanced stage cancer with solid tumor carcinomas across 16 cancer types treated with any ICI-containing regimen as …

Music As An Implementation Strategy For Evidence-Based Health Interventions In Africa: A Systematic Review Using The Re-Aim Framework, Chidi Okafor, Shravya Allena, Olufunto A Olusanya, Temitope Ojo, Juliet Iwelunmor, Et Al.

2020-Current year OA Pubs

BACKGROUND: While a growing body of scientific literature suggests that evidence-based interventions may improve health outcomes in diverse settings, little is known about the best strategies for large-scale implementation. In Africa, music-an important positive social determinant of health-leverages existing cultural values, which may effectively enhance the reach, uptake, and long-term sustainability of evidence-based interventions in the region. To understand how music interventions work, why they are effective, and with whom they resonate, this systematic review aims to evaluate the quality and empirical application of music as an implementation strategy for adopting evidence-based interventions in Africa using the RE-AIM framework as …

Mechanisms Of Change Of A Multifaceted Implementation Strategy On Fidelity To A Guideline For The Prevention Of Mental Health Problems At The Workplace: A Mechanism Analysis Within A Cluster-Randomized Controlled Trial, Andreas Rödlund, Anna Toropova, Rebecca Lengnick-Hall, Byron J Powell, Liselotte Schäfer Elinder, Christina Björklund, Lydia Kwak

2020-Current year OA Pubs

BACKGROUND: Occupational guidelines exist to support workplaces with the prevention of mental health problems (MHP) among their staff. However, knowledge of effective implementation strategies to support their implementation is limited. This study experimentally tested whether a multifaceted implementation strategy - comprising an educational meeting, five workshops, implementation teams, small cyclical tests of change, and facilitation - improves fidelity to a guideline for preventing MHP in a school setting through the pathway of change of the Capability Opportunity Motivation-Behavior (COM-B)-model. To gain a more granular understanding of the mechanisms of change, the Theoretical Domains Framework (TDF) was used to specify mediators …

Carbapenem-Resistant Enterobacterales Peri-Rectal Colonization Prevalence On Admission To Two Intensive Care Units In An Academic Hospital In India, Armaghan-E-Rehman Mansoor, Jacaranda Van Rheenen, Ige A George, Jennie H Kwon, Et Al.

2020-Current year OA Pubs

This study from a South Indian tertiary care hospital found a 41% peri-rectal Carbapenem-resistant

The Tweak/Fn14 Signaling Mediates Skeletal Muscle Wasting During Cancer Cachexia, Meiricris Tomaz Da Silva, Anirban Roy, Anh Tuan Vuong, Aniket S Joshi, Cristeena Josphien, Sajedah M Hindi, Ashok Kumar

Faculty, Staff and Student Publications

Cancer cachexia is a multifactorial syndrome characterized by progressive skeletal muscle wasting. The TWEAK-Fn14 system regulates muscle mass in diverse conditions. However, its role in the regulation of muscle mass during cancer cachexia remains less understood. Here, we demonstrate that the levels of Fn14 are induced in skeletal muscle of multiple mouse models of cancer cachexia. Muscle-specific deletion of Fn14 reduces myofiber atrophy in mouse models of pancreatic and lung cancer cachexia. Silencing of Fn14 in KPC pancreatic cancer cells prior to their implantation in mice attenuates tumor growth without affecting myofiber size. Muscle-specific deletion of Fn14 reduces the gene …

From Rags To Riches: Ai-Powered Retrieval Augmented Generation (Rag) For Just-In-Time Learning And Accelerated Onboarding In High Turnover Icus, Celestino Castanon Md, Alison A. Smith Md, Phd, Patrick Greiffenstein Md, Jennifer M. Brewer Md, Roslyn Alexander Md

Quality Improvement & Patient Safety Forum

No abstract provided.

Standardizing Ngs Testing For All Pediatric Oncology Patients: A Quality Improvement Approach, Casey Treuting Md, Zachary Leblanc Md

Quality Improvement & Patient Safety Forum

No abstract provided.

Improving Overall Resident Encounter Completion Using A Scheduled Reminder System, Evan Villemez Md

Quality Improvement & Patient Safety Forum

No abstract provided.

The Military Health History: An Ongoing Educational Initiative To Improve Veteran Healthcare, Jaclyn P. Murphy Ms, Michael C. Brands Md, Caitlin P. Martin-Klinger Md, Facp, Amanda M. Raines Phd, Randolph L. Roig Md, Faapmr

Quality Improvement & Patient Safety Forum

No abstract provided.

Assessing Ed Provider Response After Prehospital Administration Of Buprenorphine For Patients With Oud, Scott Sabo Md, Sage Teasley Mph, David Rayburn Md, Mph

Quality Improvement & Patient Safety Forum

No abstract provided.

Benefits In Performing Penicillin Challenges In The Outpatient Clinic To Reduce Hospital Costs, Jamie Tran Md, Charles Woodall Do, Dexter Matrana Do

Quality Improvement & Patient Safety Forum

No abstract provided.

Improving Overall Quality Of Care Through Bedside Shift Reporting In Acute Care, Kimberly R. Reed Dnp

Quality Improvement & Patient Safety Forum

No abstract provided.

A Root Cause Analysis In Delay Of Clinic Rooming Time, Angus M. Harper Md

Quality Improvement & Patient Safety Forum

No abstract provided.

Improving Rsv Vaccination Rates In The Resident Clinic With Rsv Vaccination Campaign, Allen Byl Do, Ilija Zecevic Md, Hannah Porter Md

Quality Improvement & Patient Safety Forum

No abstract provided.

Enhancing Colorectal Cancer Screening Awareness In A Primary Care Clinic Through Visual Aids And Posters: A Quality Improvement Initiative, Austin W. Wheeler Md

Quality Improvement & Patient Safety Forum

No abstract provided.

From Shrugs To Skills: Mastering The Shoulder Exam In The Family Medicine Clinic, Thomas Vu Md, Arden Lagrone Md, Patrick Orange Md, Raquelle Collins Md

Quality Improvement & Patient Safety Forum

No abstract provided.

Increasing Exposure To Interprofessional Roles: Creating A Culture Of Appreciation And Collaboration Across Manning Family Children's Interprofessional Groups, William Arnold Md, Alexandra Glaser Md, Andree Judd Do, Anne Reed Md, Courtney Suiter Md, Caroline T. Moreau Md

Quality Improvement & Patient Safety Forum

No abstract provided.

Alert To Action: Implementing Artificial Intelligence-Driven Clinical Decision Support Tools For Sepsis, Alexander Fixler Md, Blake Oliaro Md, Marshall Frieden Md, Christopher Girardo Md, Fiona Winterbottom Cns, Lisa Fort Md, Jason Hill Md

Quality Improvement & Patient Safety Forum

No abstract provided.

Direct Naloxone Distribution In The Emergency Department Increases Naloxone Access For Patients Following Accidental Overdose, Kasha Bornstein Md, Mph, Msc, Bridgette Egan Md

Quality Improvement & Patient Safety Forum

No abstract provided.

Is The Juice Worth The Squeeze: Anti-Xa Monitoring In Trauma Patients, Megan Dupont Bs, Jennifer M. Brewer Md, Alison A. Smith Md, Phd, Patrick Greiffenstein Md, Roslyn Alexander Do, Lillian Bellfi Pharmd

Quality Improvement & Patient Safety Forum

No abstract provided.

Improving Surgical Site Preparation In Open Abdomen Cases: A Quality Improvement Protocol For The Trauma Service, Jacob Chaisson Bs, Terri Fetty Bs, Allison A. Smith Md

Quality Improvement & Patient Safety Forum

No abstract provided.

Screening For Metabolic Dysfunction-Associated Steatotic Liver Disease In Patients With Type 2 Diabetes Mellitus, Addys Boyd Hernandez Md, Suneeta S. Ganji Md

Quality Improvement & Patient Safety Forum

No abstract provided.