Medicine and Health Sciences Commons^™

Multicenter Evaluation Of A New Strip-Based Blood Glucose System For Point-Of-Care Testing In Critical And Non-Critical Care Settings, Cristina Canada-Vilalta, Daisy D Canepa, William A Clarke, Christopher W Farnsworth, Edward O Ganser, Nienke Geerts, Barbara Goldsmith, Gary Headden, Debra Hoppensteadt, Birgit Klapperich, Ryan Matika, Gabrielle Miles, Sagori Mukhopadhyay, James H Nichols, Rebecca M O'Dell, Zubaid Rafique, Andre Schuetzenmeister, Robbert Slingerland, Ann F Stankiewicz, Jonathan R Swanson, Nam K Tran, Alan H B Wu, Brad S Karon

Faculty, Staff and Students Publications

Background: Evaluation of the performance of Cobas® Pulse (Roche Diagnostics GmbH, Mannheim, Germany), a new blood glucose (BG) monitoring system (BGMS; referred to here as BGMSA) intended for point-of-care testing using samples from patients in diverse clinical settings by intended point-of-care test operators.

Methods: Arterial, capillary, venous, or heel stick whole blood (WB) samples from patients in non-critical and critical care settings were collected and analyzed using BGMSA and the Nova StatStrip® BGMS (Nova Biomedical, Waltham, MA; referred to here as BGMSB), and a hexokinase comparator (Cobas 6000 Analyzer Series; Roche Diagnostics GmbH). The blood glucose measurement accuracy was assessed …

Antiarrhythmic Drug Use In Atrial Fibrillation Among Different European Countries – As Determined By A Physician Survey, Espen Fengsrud, Carina Blomström-Lundqvist, A. John Camm, Andreas Goette, Peter R. Kowey, Jose L. Merino, Jonathan P. Piccini, Sanjeev Saksena, James A. Reiffel, Giuseppe Boriani

Department of Medicine Faculty Papers

BACKGROUND: There is limited knowledge of physicians' antiarrhythmic drug (AAD) treatment practices for patients with atrial fibrillation and adherence to guidelines in European countries.

METHODS: An online survey (n = 321) of cardiologists, cardiac electrophysiologists and interventional electrophysiologists was conducted in Germany (DE; n = 83), Italy (IT; n = 95), Sweden (SE; n = 60) and the United Kingdom (UK; n = 83) including 96 questions on treatment practices.

RESULTS: ESC guidelines were the most important non-patient factor influencing treatment practice (55-72 %). However, while amiodarone was frequently (88-93 %) used in heart failure with reduced left ventricular ejection …

Comparison Of Propofol Microbial Contamination Following Treatment With Drug Disposal Devices

Faculty, Staff and Student Publications

Background: Pharmaceutical waste represents a major burden to the health care system and environment. Proper drug waste disposal devices are vitally needed, especially for propofol solutions that inherently carry a high risk of microbial contamination.

Objectives: The aims of this study were to compare the capabilities of 2 drug disposal systems for decontamination of propofol solutions inoculated with medical pathogens and assess chemical degradation of propofol after treatment with Fenton reagents.

Methods: Standard microbiological assays were used to assess survival and growth of Escherichia coli and Candida albicans inoculated into propofol solutions. Both a prototype instrument and a commercially marketed …

Enhancing Medication Adherence In The Older Adult By Implementing A Medication Program, Cathylee Nair

Doctor of Nursing Practice Final Project Abstract

PURPOSE The medication adherence program was a collaborative effort to develop, implement, and evaluate a medication adherence program that aims to reduce health utilization and disease exacerbation by improving medication adherence in older adults. The primary goal was to improve medication adherence by 10% within eight weeks.

BACKGROUND The medication adherence program was based out of a home health agency in Katy, Texas. Medicare utilizes home health agencies as patient support programs for providing services like medication management to reduce older adult’s health utilization and improve health outcomes at home.

METHODOLOGY The Plan Do Study Act (PDSA) model for improvement …

Determinants Of Teenage Pregnancy In Tanzania, Harun Yussuf Ayoub, Kemal Nazaruddin Siregar

Jurnal Biostatistik, Kependudukan, dan Informatika Kesehatan

Teenage pregnancies are among the leading public health problems in Tanzania. This was linked to limited education, socioeconomic disparities, cultural barriers, and inadequate access to healthcare centers. Thus, this study aims to explore the prevalence and predictors of teenage pregnancy among adolescent women using data from the 2022-2023 Tanzanian Demographic Health Survey (TDHS). The research design employed a cross-sectional approach and utilized TDHS data. The population for this study was female adolescents, while the sample was 7,545 adolescent women aged 15-24 years. Predictor variables were education level, socioeconomic status, place of residence, employment status, and lifestyle factors, including alcohol consumption …

A Flea-Borne Mystery: Unraveling Murine Typhus In A Patient With Unexplained Encephalopathy, Jose J. Loayza Pintado, Jorge A. Aboytes, Cesar Uribe

School of Medicine Publications

Murine typhus is a flea-borne rickettsial infection caused by Rickettsia typhi, commonly seen in endemic regions like Southern California and Texas. While it typically presents with fever, rash, and headache, neurological symptoms such as altered mental status are rare. We present a case of a 66-year-old male in southern Texas with alcohol use disorder who developed progressive confusion, decreased appetite, and subjective fevers. He was found to have severe hyponatremia, acute kidney injury, and atrial fibrillation with rapid ventricular response. Despite supportive care and empiric antibiotics for a urinary tract infection, his encephalopathy persisted. Further history revealed exposure to …

Anti-Viral Cd8 Central Memory Veto Cells As A New Platform For Car T Cell Therapy, Wei-Hsin Liu, Anat Globerson Levin, Assaf Lask, Galit Horn, Tova Waks, Irit Milman Krentsis, Xiaohua Su, Maksim Mamonkin, Richard E Champlin, Yair Reisner, Esther Bachar Lustig

Faculty, Staff and Student Publications

Central memory CD8 T cells exhibit marked veto activity enhancing engraftment in several mouse models of T cell-depleted bone marrow (TDBM) allografting. Graft-versus-host disease (GVHD) can be prevented by stimulation of mouse or human memory CD8 T cells against their cognate antigens under cytokine deprivation, in the early phase of culture followed by further expansion with IL21, IL15, and IL7. Thus, human anti-viral CD8 central memory veto T cells generated from CMV and EBV-positive donors are currently evaluated in a clinical trial at MD Anderson Cancer Centre (MDACC). Results in 15 patients indicate a low risk of GVHD. Considering that …

Development Of A Novel Biomarker Platform For Profiling Key Protein-Protein Interactions To Predict The Efficacy Of Bh3-Mimetic Drugs, Andrew J Kinloch, Faiyaz Rahman, Bahriye Karakas, Muhammad Shahid, Bora Lim, James A Walker, Walter D Fairlie, Kevin R Kelly, Michael H Cardone

Faculty, Staff and Student Publications

One of the hallmarks of cancer cells is their failure to respond to the cellular mechanism of apoptosis. The B-cell lymphoma 2 (BCL-2) family of proteins regulate apoptosis. Their ability to do so can be measured using several methods that in turn anticipate the fate of the cancer cell in response to apoptosis-inducing treatment. These assays ultimately identify the readiness of the cancer cell to undergo apoptosis, which is referred to as the mitochondrial priming state. These metrics, however, have been challenging to implement in the clinic.

Health Care In Women’S Carceral Spaces, Kate Gouveia Pereira

Culture, Society, and Praxis

Canada has had a long history of mistreating incarcerated women in their jails. The carceral system was built to fit around the needs of men, neglecting to consider the various health issues that only women face. For many years. federally imprisoned women were held in one deteriorated prison, the Prison for Women (P4W), and were held in abhorrent conditions and experienced many acts of violence. Despite the opening of five more prisons and funding for various programs for women, incarcerated women continue to experience violence and health crises, leaving imprisoned women extremely vulnerable to mental and physical distress. In particular, …

A Century Of Innovation: The Ada And The Forsyth Institute Partnership, Manish Chopra Dmd

Metro Denver Dental Society Articulator Magazine

This article details the new partnership between the Forsyth Institute, a century-old leader in dental and craniofacial research, and the American Dental Association to create the ADA Forsyth Institute (AFI). This global research powerhouse is pioneering breakthroughs in oral microbiology, fluoride research, saliva diagnostics and AI-driven smart fillings. The partnership represents a strategic alliance aimed at elevating dental science, education and professional standards.

From 3d-Printed Dentures To Craniofacial Discoveries: The Next Chapter In Dental Research, Laura Ramsey

Metro Denver Dental Society Articulator Magazine

This article highlights the details and importance of the University of Colorado School of Dental Medicine 40th annual Research Day by spotlighting research initiatives shaping the future of oral health. Faculty, students, and guest experts explored topics ranging from 3D-printed antimicrobial dentures and craniofacial development to global cleft care in Nepal and the integration of sex and gender in research methodologies. Dual keynotes also highlighted the importance of evidence-based education and inclusive research practices.

Kids In Need Of Dentistry (Kind) Announces New Executive Director, Erin Breen

Metro Denver Dental Society Articulator Magazine

This article introduces Ms. Colleen Lampron as the new Executive Director of Kids in Need of Dentistry (KIND). She brings 25+ years of experience in oral health and public health. Her leadership is set to advance KIND’s mission of delivering quality dental care to children across Colorado.

Colorectal Cancer And The Risk Of Mortality Among Individuals With Suicidal Ideation, Srikanta Banerjee, Jagdish Khubchandani, Stanley Nkemjika

Department of Psychiatry and Human Behavior Faculty Papers

Suicide is a major public health problem that has grown at alarming rates in the last two decades. Colorectal cancer (CRC) is one of the most common causes of cancer deaths in the United States in both males and females. However, the influence of suicidal ideation (SI) on the association between CRC and risk of mortality has not been well examined.

METHODS: For this study, the 2005-2018 National Health and Nutrition Examination Survey (NHANES), a nationally representative survey of United States adults aged 20 years or older, was utilized. CRC survivorship was determined from self-reported data on CRC, and mortality …

Gratitude, Growth & Giving Back: Closing My Chapter As Mdds President, Susan Kutis Dds

Metro Denver Dental Society Articulator Magazine

As the MDDS President, Dr. Susan Kutis, concludes her term, she reflects on how the COVID-19 pandemic renewed her commitment to organized dentistry. From addressing workforce challenges and student debt to fostering mentorship and professional growth, the article highlights the importance of volunteer leadership and the enduring value of community within MDDS.

The Evidence Behind The Risk Of Fluoride Use, Margherita Fontana Dds, Phd, Carlos González-Cabezas D.D.S., M.S.D., Ph.D., Livia Tenuta D.D.S., M.Sc., Ph.D.

Metro Denver Dental Society Articulator Magazine

This article explores the evidence behind the safety of community water fluoridation. The authors establish that no clear link to lower IQ has been proven at U.S. levels (0.7 ppm). Major health organizations, including the ADA and WHO, continue to support fluoridation as safe and effective for preventing tooth decay.

Leading With Integrity: The Foundation Of True Leadership, Amisha Singh Dds, Edd

Metro Denver Dental Society Articulator Magazine

In this Reflections from MDDS Co-Editor, Dr. Amisha Singh, she explores the power and relevance of values-based leadership in dentistry and beyond. The piece emphasizes that leadership is not just about strategy or results but about the values that guide our daily decisions, especially in times of adversity. The article challenges dental professionals to lead with integrity and create cultures rooted in trust and authenticity.

Articulator Q2 2025

Metro Denver Dental Society Articulator Magazine

The 2^nd Quarter 2025 issue focuses on new frontiers in dental research. Articles include:

• A feature from Dr. Manish Chopra on the ADA Forsyth Institute.
• Highlights from the University of Colorado’s School of Dental Medicine’s Research Day.
• The research behind the safety of community water fluoridation from Margherita Fontana, DDS, PhD; Carlow Gonzalez-Cabezas, DDS, MSD, PhD; and Livia Tenuta, DDS, MSc, PhD.

Plus, updates on local nonprofits, a reflection on leading with integrity and tips on maintain resilience in today’s volatile financial landscape.

Educating Nurses On Healthy Coping Mechanism Following Workplace Violence Occurrences, Erin Jay

Walden Dissertations and Doctoral Studies

According to the American Nurses Association (ANA), healthcare workers are five times more likely to suffer a workplace violence (WPV) injury compared to workers in other industries. Given that nurses are the foundation of healthcare delivery, WPV is a cause for concern for most healthcare organizations. In the local organization, leadership has identified an increase in reported WPV occurrences among nurses. Given this, leadership agreed that an educational intervention focused on strategies to address WPV was warranted. Thus, the purpose of this doctor of nursing practice (DNP) project was to determine whether an educational intervention focused on healthy coping mechanisms …

Staff Education To Improve Knowledge Of Wound Documentation Skills Among Inpatient Nurses, Rouine Kay Patron Litorja

Walden Dissertations and Doctoral Studies

While many healthcare organizations have established wound documentation protocols, maintaining consistent, high-quality documentation remains a widespread challenge in clinical practice. In this staff education project, I addressed the implementation of a staff education program to increase nurses' knowledge about evidence-based practices regarding wound documentation. The staff education initiative was conducted in a medical telemetry unit, with 17 nurses participating. A pretest-posttest design was employed to evaluate the impact of the education. The aggregate pretest and posttest scores were analyzed using the Normalized Learning Gain (NLG) formula. The NLG gain of 0.37, equated to a 37% improvement in knowledge a moderate …

Neovascular Pruning By Ido1 Inhibitors Can Potentiate Immunogenic Cytotoxicity Of Ischemia-Targeted Agents To Synergistically Enhance Anti-Pd-1 Responsiveness, Shih-Chun Shen, Souvik Dey, James B. Duhadaway, Erika Sutanto-Ward, Maurice T. Hampton, Serguei V. Kozlov, George C. Prendergast, Alexander J. Muller

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

BACKGROUND: Strategies for deploying indoleamine 2,3-dioxygenase 1 (IDO1)-targeted therapies for use against cancer have focused on IDO1's role in promoting peripheral immune tolerance that shields tumors from effector T cells. However, preclinical investigation of both primary and metastatic tumor development in the lungs has uncovered a previously unappreciated role for IDO1 in directing a counterregulatory response to interferon (IFN)-γ that realigns the local inflammatory environment to promote tumor neovascularization. Understanding how to therapeutically leverage the ability of IDO1 inhibitors to subvert inflammatory neovascularization within the tumor microenvironment has potential ramifications for future clinical development of these compounds.

METHODS: Pulmonary metastases …

Social Eating Role In Ultra-Processed Food Consumption Among Urban Young Adults: The 2018 Indonesian Food Barometer, Imas Arumsari, Nabilla Ayusyah Putri, Siti Nur Lulu Lathifah, Gita Aisyah Astrid Rosalba, Helda Khusun, Judhiastuty Februhartanty, Rahmatika Nur Aini

Kesmas

This study investigated the differences in ultra-processed food (UPF), fruit, vegetable, and total fat consumption in different aspects of social eating among urban young adults. This cross-sectional study used the 2018 Indonesian Food Barometer dataset with 180 participants aged 18–25 years living in urban areas from 6 provinces in Indonesia. The data on social eating (cooking habits, eating out, and eating alone), UPF, fruits, and vegetables were obtained from an extended 24-hour food recall interview. The Mann-Whitney U test (CI 95%) was employed for data analysis. This study found that groups with less frequent cooking habits tended to have more …

Understanding Occupational Health And Safety Regulations And The Influence On Students' Behavior In Practical Workshops, M. Yusuf, I Ketut Gde Juli Suarbawa, Ni Wayan Merda Surya Dewi, Ni Wayan Sadiyani, I Made Sudana

Kesmas

Understanding occupational health and safety (OHS) is essential for engineering students, especially in high-risk environments such as mechanical workshops, where unsafe practices can lead to accidents and injuries. Although Regulation Number 5 of 2018 from the Indonesian Ministry of Manpower mandates OHS implementation in all workplaces, students’ knowledge and behavior still fall short of the expected safety standards. This study aimed to measure students’ understanding of OHS, their basic knowledge of OHS law, and their behavior during workshop practicum activities. A cross-sectional research design was used, involving 203 students in State Polytechnic in Badung District, Indonesia. Data were collected through …

Job Satisfaction Among Health Workers At Primary Health Care In Palembang City, Indonesia, Asmaripa Ainy, Merri Nurmala Sarri, Poppy Fujiyanti, Hartati Inaku, Tannia Tembo

Kesmas

Health workers at primary health care are the frontline providers of community health services. This study aimed to investigate the level of job satisfaction of health workers at primary health care in Palembang City, South Sumatra Province, Indonesia, and its influencing factors. Using a questionnaire developed by the authors' team, the study involved 257 samples. A total of 66.15% of respondents indicated high satisfaction, 21.79% reported moderate satisfaction, and 12.06% expressed dissatisfaction. A statistically significant correlation was found between knowledge, skills, income, promotion opportunities, work supervision, and relationships with colleagues and job satisfaction (p-value <0.001). The correlations were strong, with Spearman's rho of 0.822, 0.869, 0.912, 0.895, and 0.821, respectively. Statistical analysis of the Wilcoxon rank-sum and Kruskal-Wallis tests showed no significant differences in median satisfaction scores between sociodemographic groups (p-value 0.072 to 0.552>0.05). These findings showed that job …

Maternal Vitamin C Deficiency And Genetic Risk Factors Contribute To Congenital Defects Through Dysregulation Of Dna Methylation, Riet Cornelis, Spyridon Champeris Tsaniras, Kobe De Ridder, Bernard Thienpont, Huiyong Cheng, Qiuying Chen, Daniel Kraushaar, Richard H Finnell, Steven S Gross, Kian Peng Koh

Faculty, Staff and Students Publications

Maternal dietary insufficiencies can reshape the fetal epigenome during gestation, contributing to birth defects and developmental disorders. Vitamin C (VitC) is a critical co-factor for Ten-Eleven-Translocation (TET) DNA demethylases, but the impact of its deficiency on embryonic development has gone largely unappreciated. Here, we show that maternal VitC deficiency in L-gulonolactone oxidase (Gulo)-deficient mice, which like humans are unable to synthesize VitC, can cause highly penetrant developmental delays and malformations in non-inbred embryos during the vulnerable period of gastrulation. DNA hypermethylation in Gulo−/− embryonic neural tissues of susceptible strains increases with VitC dose reduction and with the …

From Checkboxes To Emojis: A Novel Approach To Patient-Reported Outcomes In Multiple Sclerosis, Nabeela Nathoo, Elizabeth J Atkinson, Jiye Son, Eoin P Flanagan, Sean J Pittock, Ugur Uygunoglu, Orhun H Kantarci, Burcu Zeydan

Faculty, Staff and Students Publications

Background: Patient-reported outcome measures (PROMs) improve multiple sclerosis (MS) management by reflecting patients' perspectives of their disease. Mayo Clinic Electronic Emoji Based Neurological Impairment Status (MEBNIS) is a short PROM consisting of four equally-weighted domains (MemoryMEBNIS, MoodMEBNIS, Fatigue-SleepinessMEBNIS, and AmbulationMEBNIS) and CompositeMEBNIS, which are based on emojis.

Objective: To investigate the correlations of MEBNIS with patient-reported, examination-based, performance-based, and radiological metrics of disease severity in persons with MS (pwMS).

Methods: PwMS (n = 195) prospectively completed MEBNIS, Expanded Disability Status Scale (EDSS), MS Functional Composite (MSFC) and its subtests [25-Foot Walk Test (25FWT), 9-Hole Peg Test (9HPT), Paced Auditory Serial …

Secreted Phosphoprotein 1 In Lung Diseases, Jennifer L Larson-Casey, Ivan O Rosas, Chao He

Faculty, Staff and Students Publications

Secreted phosphoprotein 1 (SPP1), also known as osteopontin (OPN) or early T lymphocyte activation protein 1 (ETA-1), is a multifunctional protein involved in numerous biological processes, including immune modulation, stress response, and tissue remodeling. The role of SPP1 in interstitial lung diseases (ILDs) has become an area of increasing interest, given its elevated expression in various ILDs such as idiopathic pulmonary fibrosis (IPF), connective tissue disease-associated ILD (CTD-ILD), and pneumoconiosis, especially with recent data derived from single-cell RNA sequencing. In addition to ILDs, SPP1 has been implicated in infectious granulomatous lung diseases, lung and pleural malignancies, airway diseases, and COVID-19. …

Group-Based Management Of People With Greater Trochanteric Pain Syndrome: A Service Evaluation, Stuart Lloyd, Jack Thomas

South West Clinical School Journal

#400WORD: KNOWLEDGE + ACTION

Nurses’ Knowledge And Practice In The Care Of Patients With Delirium In The Intensive Care Unit: A Service Evaluation Project Proposal, Patience Elosiuba

South West Clinical School Journal

#400WORDS: CHIEF NURSING OFFICER’S RESEARCH FELLOWS EVIDENCE IMPLEMENTATION PROJECTS

Hypertension Literacy For Healthcare Providers, Maninder Kaur Dhaliwal

Walden Dissertations and Doctoral Studies

When medical staff lack sufficient training in hypertension literacy, it significantly impacts patient outcomes, expenses, and quality of life. Uncontrolled hypertension increases health care costs by causing frequent emergency room visits and hospital stays. After a thorough needs assessment, it was identified at the project site that nurse practitioners were not knowledgeable about the most recent recommendations for managing hypertension and patient education techniques. This practice gap was also contributed to by a lack of structured training and time for learning. The practice-focused question for this project was: Among health care staff, how does implementing a staff education initiative on …

Enhancing Intimate Partner Violence Screening In Primary Care: A Staff Education And Quality Improvement Initiative, Izoduwa Asoro

Walden Dissertations and Doctoral Studies

This project addresses the often-overlooked epidemic of intimate partner violence (IPV) in primary care settings through a novel staff education and quality improvement initiative focused on transforming screening practices. A significant challenge in detecting IPV is the inadequate training of healthcare providers and the absence of rigorous screening measures, which leads to unmet patient needs and exacerbated trauma. By enhancing the knowledge of primary care staff regarding IPV and training them to effectively use validated screening tools, the initiative aims to improve detection rates. Analytical strategies, including pre-and post-training questionnaires and role play, were employed to evaluate the effectiveness of …