Medicine and Health Sciences Commons^™

Associations Between Combat Exposure, Moral Injury, And Suicidality Among U.S. Military Members: The Moderating Impact Of Positive Rumination, Jeffrey M. Gabelmann

Psychology Theses & Dissertations

Numerous studies have documented the risk for suicide among recent-era veterans with combat experience. Recently, moral injury has emerged as a possible contributor to suicidality in veterans. To that end, no study has approached the combat exposure-moral injury-suicidality link with a focus grounded in positive psychology. Specifically, the present study explored whether positive rumination, or the reflection on positive emotions and moods, may buffer the deleterious effects of potentially traumatic experiences in warzones on moral injury and suicidality. This study was a secondary analysis of 250 current or former U.S. military members (M_age = 33.3 years) who had …

The Shared Experiences Of Novice, Full-Time Allied Dental Community College Educators, Misty L. Mesimer

Educational Leadership & Workforce Development Theses & Dissertations

A well-prepared oral healthcare workforce is essential to the overall health of the general population. A knowledgeable and qualified workforce would be non-existent without strong academic programs and faculty to prepare oral health professionals. For over 20 years, the dental and allied dental educator workforce has been a concern for the oral health professions. Since most allied dental education programs are based in community and technical colleges, it is crucial to thoroughly understand the transition experiences of faculty teaching at these institutions. It is only through application and use of this knowledge that these faculty can be recruited, supported, and …

Use Of Ultrasound For Identification Of Musculoskeletal Injury In Active Populations, Kathleen Karen Hogan

Rehabilitation Sciences Theses & Dissertations

Lower extremity tendinopathies and fasciopathy conditions are prevalent amongst sedentary individuals,^1,2 athletes,^3,4 elite runners,^5,6and military personnel⁷ and can lead to chronic disability and reduction in quality of life. ^8,9 Both tendinopathy and fasciopathy are thought to be mechanical in nature and caused by acute or chronic overloading leading to a disruption in the uniformity of the soft tissue structure. Ultrasound imaging has gained popularity in the last decade among many sports medicine clinicians to gain information regarding tissue structure for musculoskeletal injury (MKSI) management. Ultrasound imaging allows for the evaluation of in-vivo structures and at …

Prevalence Of Sexuality Implicit Bias In Entry-Level Dental Hygiene Students – A Pilot Study, Monica Mercedez Drew

Dental Hygiene Theses & Dissertations

Purpose: Bias and discrimination may create barriers and affect the delivery of culturally competent care to sexual minorities. An awareness of biases early in education may promote equitable care and increase the quality of oral healthcare delivered to diverse populations. The purpose of this study was to determine the prevalence of sexuality-implicit attitudes in entry-level dental hygiene students at one university. Methods: This cross-sectional study included a convenience sample of junior and senior dental hygiene students (n=74) and was determined exempt by a university Health Sciences Human Subjects Review Committee (2151633-2). The Implicit Associations Test (IAT) is a validated tool …

Gender Measurement Invariance Of The Minnesota Multiphasic Personality Inventory - Adolescent - Restructured Form (Mmpi-A-Rf) Internalizing And Externalizing Specific Problem Scales, Thomas Jay Augustin

Psychology Theses & Dissertations

Due to social, psychological, biological, and cultural differences in adolescent development, it is important to evaluate measurement invariance in psychological measures. Although the Minnesota Multiphasic Personality Inventory (MMPI) assessments have a plethora of research to evaluate their utility in clinical practice, few published studies have examined the measurement invariance between males and females for any of the scales in the adolescent versions (MMPI-A/MMPI-A-RF). The present study examined the measurement invariance of the MMPI-A-RF Internalizing and Externalizing Specific Problem Scales between male and female adolescents. Data were obtained from an outpatient sample and from Pearson’s mail-in service resulting in 1,622 valid …

Body Image Dissatisfaction, Positive Body Image, And Health Behaviors During Pregnancy: A Between-Trimester Comparison, Cassidy M. Sandoval

Psychology Theses & Dissertations

Body image during pregnancy is a critical concern for maternal and fetal health, as it is associated with adverse health outcomes for mothers and neonates. Findings regarding if and how body image dissatisfaction changes during pregnancy are equivocal. A vast majority of studies examining body image during pregnancy focus on negative aspects of body image (e.g., body dissatisfaction), and there are limited studies of positive body image during pregnancy. Although the literature examining body image’s association with mental health concerns during pregnancy is well-developed, there is far less research exploring associations with physical health. Given these notable gaps, the present …

Ceramide-Mediated Orchestration Of Oxidative Stress Response Through Filopodia-Derived Small Extracellular Vesicles, Zainuddin Quadri, Ahmed Elsherbini, Simone M. Crivelli, Salim S. El-Amouri, Priyanka Tripathi, Zhihui Zhu, Xiaojia Ren, Liping Zhang, Stefka D. Spassieva, Mariana N. Nikolova‑Karakashian, Erhard Bieberich

Markey Cancer Center Faculty Publications

Extracellular vesicles (EVs) are shed from the plasma membrane, but the regulation and function of these EVs remain unclear. We found that oxidative stress induced by H 2 O 2 in Hela cells stimulated filopodia formation and the secretion of EVs. EVs were small (150 nm) and labeled for CD44, indicating that they were derived from filopodia. Filopodia-derived small EVs (sEVs) were enriched with the sphingolipid ceramide, consistent with increased ceramide in the plasma membrane of filopo- dia. Ceramide was colocalized with neutral sphingomyelinase 2 (nSMase2) and acid sphingomyelinase (ASM), two sphingomyelinases generating ceramide at the plasma membrane. Inhibition of …

Soxb1 Transcription Factors Are Essential For Initiating And Maintaining Neural Plate Border Gene Expression, Elizabeth Schock, Joshua R. York, Austin P. Li, Ashlyn Y. Tu, Carole Labonne

Markey Cancer Center Faculty Publications

SoxB1 transcription factors (Sox2/3) are well known for their role in early neural fate specification in the embryo, but little is known about functional roles for SoxB1 factors in non-neural ectodermal cell types, such as the neural plate border (NPB). Using Xenopus laevis, we set out to determine whether SoxB1 transcription factors have a regulatory function in NPB formation. Here, we show that SoxB1 factors are necessary for NPB formation, and that prolonged SoxB1 factor activity blocks the transition from a NPB to a neural crest state. Using ChIP-seq, we demonstrate that Sox3 is enriched upstream of NPB genes in …

14-3-3Ζ Suppresses Rankl Signaling By Destabilizing Traf6, R. Ayyasamy, S. Fan, P. Czernik, B. Lecka-Czernik, Somsubhra Chattopadhyay, R. Chakravarti

Markey Cancer Center Faculty Publications

Macrophages are essential regulators of inflammation and bone loss. Receptor activator of nuclear factor-κβ ligand (RANKL), a pro-inflammatory cytokine, is responsible for macrophage differentiation to osteoclasts and bone loss. We recently showed that 14-3-3ζ-knockout (Ywhaz^KO) rats exhibit increased bone loss in the inflammatory arthritis model. 14-3-3ζ is a cytosolic adaptor protein that actively participates in many signaling transductions. However, the role of 14-3-3ζ in RANKL signaling or bone remodeling is unknown. We investigated how 14-3-3ζ affects osteoclast activity by evaluating its role in RANKL signaling. We utilized 14-3-3ζ-deficient primary bone marrow–derived macrophages obtained from wildtype and Ywhaz^{KO …}

Discussions Of Cancer Survivorship Care Needs: Are There Rural Versus Urban Inequities?, Tyrone F. Borders, Lindsey R. Hammerslag

Markey Cancer Center Faculty Publications

Background: Rural cancer survivors may face greater challenges receiving survivorship care than urban cancer survivors.

Purpose: To test for rural versus urban inequities and identify other correlates of discussions about cancer survivorship care with healthcare professionals.

Methods: Data are from the 2017 Medical Expenditure Panel Survey (MEPS), which included a cancer survivorship supplement. Adult survivors were asked if they discussed with a healthcare professional 5 components of survivorship care: need for follow-up services, lifestyle/health recommendations, emotional/social needs, long-term side effects, and a summary of treatments received. The Behavioral Model of Health Services guided the inclusion of predisposing, enabling, and need …

Diffuse Reflectance Spectroscopy For Optical Characterizations Of Orthotopic Head And Neck Cancer Models In Vivo, Pranto Soumik Saha, Jing Yan, Caigang Zhu

Markey Cancer Center Faculty Publications

We demonstrated an easy-to-build, portable diffuse reflectance spectroscopy device along with a Monte Carlo inverse model to quantify tissue absorption and scattering-based parameters of orthotopic head and neck cancer models in vivo. Both tissue-mimicking phantom studies and animal studies were conducted to verify the optical spectroscopy system and Monte Carlo inverse model for the accurate extraction of tissue optical properties. For the first time, we reported the tissue absorption and scattering coefficients of mouse normal tongue tissues and tongue tumor tissues. Our in vivo animal studies showed reduced total hemoglobin concentration, lower tissue vascular oxygen saturation, and increased tissue scattering …

A Probabilistic Approach To Estimate The Temporal Order Of Pathway Mutations Accounting For Intra-Tumor Heterogeneity, Menghan Wang, Yanqi Xie, Jinpeng Liu, Austin Li, Li Chen, Arnold Stromberg, Susanne Arnold, Chunming Liu, Chi Wang

Markey Cancer Center Faculty Publications

The development of cancer involves the accumulation of somatic mutations in several essential biological pathways. Delineating the temporal order of pathway mutations during tumori- genesis is crucial for comprehending the biological mechanisms underlying cancer development and identifying potential targets for therapeutic intervention. Several computational and statistical methods have been introduced for estimating the order of somatic mutations based on mutation profile data from a cohort of patients. However, one major issue of current methods is that they do not take into account intra-tumor heterogeneity (ITH), which limits their ability to accurately discern the order of pathway mutations. To address this …

Response To Replication Stress And Maintenance Of Genome Stability By Wrn, The Werner Syndrome Protein, David K. Orren, Amrita Machwe

Markey Cancer Center Faculty Publications

Werner syndrome (WS) is an autosomal recessive disease caused by loss of function of WRN. WS is a segmental progeroid disease and shows early onset or increased frequency of many characteristics of normal aging. WRN possesses helicase, annealing, strand exchange, and exonuclease activities and acts on a variety of DNA substrates, even complex replication and re- combination intermediates. Here, we review the genetics, biochemistry, and probably physiological functions of the WRN protein. Although its precise role is unclear, evidence suggests WRN plays a role in pathways that respond to replication stress and maintain genome stability particularly in telomeric regions.

Validating An Automated Rodent Ultrasonic Vocalization Data Collator, Devin Mark Kellis

Theses and Dissertations

Rodent ultrasonic vocalizations (USVs) are a key dependent measure within behavioral science that have translational relevance with respect to medical, especially neuropsychiatric, illnesses. In recent years, several programs have been developed to enable the recording, labeling, and parameterization of rodent USVs via conventional, machine learning, or deep learning approaches. However, there remains a need to further automate the downstream process of data collation so that labeled and classified USV parameters can be rapidly formatted and analyzed via statistical approaches based on experimenter preferences. The aim of this thesis was therefore to validate an automated vocalization data collator (AVDC) to expedite …

Wide-Field Optical Coherence Tomography Imaging Improves Rate Of Change Detection In Progressing Glaucomatous Eyes Compared With Standard-Field Imaging, Christopher Bowd, Akram Belghith, Jasmin Rezapour, Jost B. Jonas, Leslie Hyman, Robert N. Weinreb, Linda M. Zangwill

Wills Eye Hospital Papers

PURPOSE: To compare rates of retinal nerve fiber layer change over time in healthy, eyes with nonprogressing glaucoma and eyes with progressing glaucoma using single wide-field (SWF) and optic nerve head (ONH) cube scan optical coherence tomography (OCT) images.

METHODS: Forty-five eyes of 25 healthy individuals and 263 eyes of 161 glaucoma patients from the Diagnostic Innovations in Glaucoma Study were included. All eyes underwent 24-2 visual field testing and OCT (Spectralis SD-OCT) ONH and macular imaging. SWF images (up to 43° × 28°) were created by stitching together ONH cube scans centered on the optic disc and macular cube …

Effect Of Catastrophic Medical Insurance On Healthcare Service Utilization And Quality, Ruiqi Ding

Dissertations and Theses Collection (Open Access)

China implemented catastrophic medical insurance (CMI) program to provide additional reimbursement for individuals requiring extensive healthcare services due to severe illnesses. This study empirically assesses the impact of the CMI program on the healthcare utilization and quality of care for severely ill patients, using medical insurance claim data from 2012 to 2018 in a capital city in China. The analysis yields the following conclusions: First, CMI decreased the medical expenditure of severe patients, but it had no impact on alleviating the financial burden. Second, CMI curbed abuse and saved medical resources, and in the meantime, it increased the use of …

Status Epilepticus: Initial Management, Children's Mercy Kansas City

Clinical Pathways

No abstract provided.

Foreign Body Ingestion, Children's Mercy Kansas City

Clinical Pathways

No abstract provided.

Look To Your Ada, Mda For Health, And Wellness Help, Michelle C. Dziurgot Dds

The Journal of the Michigan Dental Association

This month, MDA Journal Editor Michelle C. Dziurgot, DDS, highlights dentists' mental health challenges, emphasizing the support available through the ADA and MDA. She references a 2021 survey showing high depression rates among dentists and lists depression symptoms. The ADA provides resources and a confidential health and wellness program. Similarly, the MDA offers the Member Assistance Program with counseling services for dentists and their families. Dziurgot urges dentists to seek help and not ignore their feelings, noting the persistent stress from the pandemic and the importance of utilizing available support.

The Mda Forensic Dental Team Needs More Volunteers, Patrick Houlihan Dds

The Journal of the Michigan Dental Association

The Michigan Dental Association Forensic Dental Identification Team (MDA-FDIT) urgently needs more volunteers. In this article, learn of their impressive record of service to the public and the profession, which has been widely recognized for the important role it plays in the identification of both individual victims and those of mass disasters. Formed in the early 1980s, MDA-FDIT plays a crucial role in identifying disaster victims using dental records. The team has been instrumental in identifying victims from incidents like the 1987 Northwest Flight 255 crash and has assisted in various mass-casualty situations, including 9/11 and Hurricane Katrina. MDA-FDIT works …

Mda At Your Service: How Can I Protect My Practice From Cybercrime?, Kristin Johnson Dds

The Journal of the Michigan Dental Association

Cybercrime poses a significant threat to dental practices. To safeguard against attacks, the federal Cybersecurity and Infrastructure Security Agency recommends educating employees on phishing, enforcing strong passwords, requiring multifactor authentication, and updating software regularly. Additional resources include Complete Dental IT for security assessments and MDA Insurance for cyber liability policies. Further support for dental practices includes the transferability of MDA Radiography Training vouchers, using specialized CPA firms for better financial insights, and guidance on insurance network decisions for hiring associates.

The New Professional: The Important Role Of Organized Dentistry In Early Career Success, Amrita Patel Dds

The Journal of the Michigan Dental Association

As a new dentist, navigating the professional world requires more than clinical skills; involvement in organized dentistry is crucial. It fosters personal and professional growth, provides continuous learning through seminars and workshops, and offers networking and mentorship opportunities. Additionally, it serves as a collective voice advocating for the profession’s interests, influencing policies, and fostering leadership development. Membership grants access to practice resources and support services, helping new dentists navigate challenges and build successful careers. Ultimately, organized dentistry creates a supportive community, essential for early career success.

Exploring The Relationships Between Food Insecurity, Wic Participation, Early Life Feeding Practices, Diversity Of Dietary Exposures, And Diet Quality In The First Two Years Of Life, Vivian M. Drewelow

Master's Theses

Diet quality during early childhood is a strong predictor of mental and physical outcomes, as well as future diet quality. Although many factors determine diet quality during childhood, food insecurity is a significant predictor of lower diet quality. On the other hand, participation in nutrition assistant programs, such as the Special Supplemental Nutrition Program for Women, Infants, and Children (WIC) is a significant predictor of higher diet quality. In addition, specific feeding practices, including timing of complementary food and beverage (CFB) introduction, types of CFB introduced early, and diversity of dietary exposures (DD), in the first year may predict future …

Lexical Access In Women With The Fmr1 Premutation, Nadia Sabeh Ayon

Theses and Dissertations

Background: Emergent research indicates that women carrying the FMR1 premutation (FXpm) may encounter difficulties in language skills, including increased dysfluencies, a reduction in the quantity and diversity of words produced, and increased word retrieval errors with age (Sterling et al., 2013; Bredin-Oja et al., 2021). Objectives: The present study aims to assess semantic and phonological lexical access skills in FXpm women as well as to examine the impact of cognitive load (time pressure) on lexical access.

Methods: Forty-two FXpm women and 25 control women, aged 26-65 years (M=46.22, age-matched: p=.115), participated. The Network Production Task (Oomen & Postma, 2001), featuring …

Examining Risk Factors For Early-Onset Breast Cancer, Jennifer Grace Taylor

Theses and Dissertations

Introduction: There have been great advancements in screening and in the identifying of risk factors associated with breast cancer, however, there is a lack of information of these factors in women with breast cancer occurring under the age of 45, known as early-onset breast cancer (EOBC). EOBC is often found at later stages, negatively impacting young women’s careers, family planning, and mental health. Additionally, because of the health disparities that exist within the U.S. health care system, women belonging to racial and ethnic groups, specifically young Black women, tend to have poorer outcomes and higher mortality rates of EOBC …

Sleep Quality And Quantity Assessment Among African American Survivors Of Lung Cancer With And Without Chronic Obstructive Pulmonary Disease (Copd), Amanda Rae Myhren Dyer

Theses and Dissertations

Introduction: Improving the quality of life of survivors of early-stage lung cancer (NSCLC, Stages I - IIIa) requires attention to persistent, burdensome symptoms, including sleep disturbances. While research exists regarding sleep quality, sleep quantity, and sleep disturbances in cancer survivors, minimal research targets this minority survivor population. The purpose of this study was to measure and assess sleep quality, sleep quantity, and sleep disturbances among African American survivors of lung cancer. Based on the Symptom Management Theory, our comprehensive assessment focuses on a racial minority group and multiple diagnostic groups (COPD vs. No COPD). Methods: This two-group, cross-sectional, descriptive study …

Exploring The Impact Of Neonatal Transport On The Health Of Black Preterm Infants And Psychosocial Challenges Faced By Parents In Relation To Social Determinants Of Socioeconomic And Racial Inequities, Karen Faye Warren

Theses and Dissertations

Neonatal transport is a unique aspect of preterm birth. This descriptive, exploratory dissertation study used a multiple-case study design, and mixed methods approach to describe the trajectory of Black preterm outborn infants and their mothers from birth, through transport to a referral center through NICU hospitalization until discharge, for a detailed analysis of each case. The specific aims were 1) Describe each infant's transport trajectory, including baseline characteristics of the community hospital of birth (size, level of care, birthing resources), transport characteristics (mode, distance, personnel), and infant health from birth to arrival of regional referral neonatal intensive care unit; 2) …

Improving Drug Repurposing Success: Integrating Large Database Claims Analysis In Drug Discovery, Joseph Magagnoli

Theses and Dissertations

Drug repurposing has emerged as an innovative strategy to identify new therapeutic uses for existing medications. However, with few notable exceptions, repurposing existing drugs has limited overall success, often failing in randomized controlled trials (RCTs) due to inadequate treatment efficacy in new clinical settings. To improve success rates, I propose a framework titled REMIDY: Retrospective and Experimental Methods Integration for Drug DiscoverY. The REMIDY framework incorporates retrospective claims analysis into the drug discovery process. I demonstrate that retrospective analysis can leverage extensive administrative and clinical data to address translational gaps between pre-clinical experimental models and RCTs. For example, pre-clinical experimental …

Nonverbal Iq Test Performance In Preschool-Age Children With Varying Language, Sandra Danelle Irvin

Theses and Dissertations

Purpose – This study aims to investigate the impact of two types of factors on IQ test performance in children with variation in language ability. The two types of factors studied here are: a) test characteristics (i.e., complexity of test directions) and test-taker characteristics (i.e., language ability). Method – Four participants, ages 4-7, completed norm referenced assessments for language and intelligence. Results – Descriptive results suggest no discernable trends between performance on language assessments and nonverbal IQ measures. The results demonstrated a discernable negative trend between performance on nonverbal IQ measures and linguistic complexity of instructions. Implications – While the …

An Examination Of Self-Identity In Relation To Smoking And Vaping In South Carolina, Jaron Hoani King

Theses and Dissertations

BACKGROUND

This dissertation examines self-identity in the context of smoking and vaping among adults in South Carolina (SC) using data from the 2023 SC Adult Tobacco Survey (n=1370). The conceptual model created to guide this dissertation is called the “Smoker and Vaper Behavior-Identity Model” and draws constructs from theoretical frameworks in health behavior and social identity theories. Behavior was defined as lifetime and past 30 day cigarette or e-cigarette use. Self-identity was defined by asking respondents with a history of cigarette or e-cigarette use “Do you consider yourself a smoker/vaper”, respectively.

METHODS

First, this study assesses the prevalence of mismatching …