Medicine and Health Sciences Commons^™

Occupational Therapists’ Consideration Of Sexual Orientation And Gender Identity When Working With Adolescents: A Preliminary Study, Kristin S. Willey, Dana Howell, Camille Skubik-Peplaski

The Open Journal of Occupational Therapy

Background: Adolescents who identify as lesbian, gay, bisexual, transgender, intersex, asexual, and plus (LGBTQIA+) have reduced quality of health care because of stigma, lack of awareness, and insensitivity. Recently the American Occupational Therapy Association added sexual orientation and gender identity (SOGI) as a personal factor in the Occupational Therapy Practice Framework. It is important to understand how occupational therapists incorporate SOGI into their services provided to adolescents.

Purpose: This study explored if occupational therapists considered an adolescent client’s SOGI when providing services. Research questions included: do occupational therapists perceive that SOGI influences adolescents’ occupations, and do occupational …

Understanding The Needs Of Gender-Diverse Youth And Young Adults And Their Staff Members In Homeless Shelters And Supported Housing, Sharon Gutman, Ashley Choi, Alexis Kearney, Margaret Swarbrick Dr

The Open Journal of Occupational Therapy

Background: Gender-diverse youth experience twice the risk for homelessness as their same-age cisgender peers and report experiencing discrimination in homeless shelters and supported housing.

Method: Eighteen participants (9 gender-diverse residents and 9 staff members) were interviewed individually to understand their experience of and needs in these settings.

Results: The major findings included: (a) Gender-diverse service recipients felt unsafe and vulnerable in these facilities. Sharing space in which to carry out occupations of vulnerability often triggered anxiety and PTSD. (b) Gender-diverse service recipients felt that staff members did not understand how cumulative trauma adversely affected participation in programmatic …

Effectiveness Of An Occupational Therapy-Led Social Skills Group Using Parent Training: A Pilot Study, Sheryl Eckberg Zylstra, Yvonne L. Swinth, Aimee Sidhu, Julie Anderson

The Open Journal of Occupational Therapy

Background: Social skills support the development of a positive self-concept and engagement in a variety of life roles, habits, and routines. The Occupational Therapy Practice Framework clearly defines the occupational therapist’s role in working with children with difficulties in social skills; however, little research exists examining the effectiveness of occupational therapy-led group interventions to support social skills development. Incorporating parent training into social skill development can improve overall outcomes and reinforce skill development across contexts.

Objective: The purpose of this pilot study was to determine whether an occupational therapy-led social skill group, combined with parent training, was effective …

The Use Of Occupational Therapy Interventions In A Hematology-Oncology Pediatric Intensive Care Unit, Lucy Weathers, Sarah Schwartzberg, Kenneth Pettit, Fang Wang, Shilpa Gorantla, Saad Ghafoor

The Open Journal of Occupational Therapy

Objectives: The purpose of this study was to describe the role of occupational therapy (OT), including types of interventions that can be provided in a pediatric intensive care unit (PICU) setting, and to evaluate the use and safety of OT services in an early mobility program.

Methods: A retrospective review via medical records occurred between January 2019 and June 2020. The frequencies and adverse events of OT interventions were compared preimplementation (January–September 2019) and postimplementation (October 2019–June 2020) of an early mobility program.

Results: A convenience sample of 56 patients comprised the preimplementation group, and 83 comprised the postimplementation …

Finding Harmony In Academic Life: Blending The Teacher-Scholar Model, Shirley P. O'Brien

The Open Journal of Occupational Therapy

Occupational therapy affords many role options. Academic faculty is one example of a role. Faculty are expected to participate in teaching, service, and research/scholarship activities within their roles, as shaped by institutional type. This article highlights the academic journey and considerations for embracing leadership as teacher-scholars in occupational therapy.

Formative Research About Shared Decision Making In The Treatment Of Opioid Use Disorder In Pregnant Women, Ruth Jeminiwa, Phd, Fadel Dadabaev, Pharmd, Heeyoung Kim, Pharmd, Caroline Popielaski, Pharmd, Sohyeon Park, Pharmd, Meghan Gannon, Phd Msph, Diane Abatemarco, Phd, Msw, Ronald Myers, Phd, Dsw

College of Pharmacy Posters

Background

• Shared Decision Making (SDM) is an evidence-based practice that involves a discussion between a health care professional and patient to reach a mutual agreed upon treatment plan.(1)
• A recent nationally-representative study indicates that only 39% of physicians use SDM for 50% or fewer Pregnant Women with Opioid Use Disorders (PWOUD).(2)
• Little is known about factors that affect SDM among PWOUD. This research project aimed to address this knowledge gap.

Transitions Of Care Practice Models: Innovations Across Different Health Settings, Laressa Bethishou, Noah Fang

Pharmacy Faculty Articles and Research

"Being discharged from a hospital may be a joyous occasion for a patient with a long length of stay, but this process may also be riddled with medication issues. With a deluge of new medications, unclear instructions, and new costs that may be unaffordable, many patients face challenges that are all too common. Additionally, the medication list may be fraught with discrepancies of missing or inaccurate home medications, duplicate therapies of new medications prescribed, or drug-drug interactions of old and new medications.

Pharmacists and pharmacy personnel who support patients during transitions of care (TOC) are very familiar with the consequences …

Educating Nurses On The Components Of A Healthy Work Environment, Kathryn L. Scott

Doctoral Dissertations and Projects

It is essential to look at the entire picture to ensure patient care is offered in the highest quality manner possible. One must look at patient satisfaction, quality outcomes, and job satisfaction experienced by the nursing staff providing care to accomplish this goal. Research has shown that nurse burnout has increased exponentially as of late. Some blame the COVID-19 pandemic; others look at the generation of nurses graduating from nursing school and starting in the field, comparing the baby boomer nurse to the Gen Z nurse. Many factors are involved, and with the recent addition of paying particular attention to …

Psychological Profile Of Brazilian Jiu-Jitsu Athletes, Leandro De Lorenco-Lima

Doctoral Dissertations and Projects

Martial arts and combat sports have been shown to influence several desirable psychological factors positively. This quantitative study aimed to explore the differences in mental strength, resilience, grit, self-efficacy, self-control, aggression, life satisfaction, and mental health between belt ranks in Brazilian Jiu-Jitsu (BJJ) athletes. A sample of 410 BJJ participants (323 males and 87 females) from 18 to 60 years of age was included in this study. Data was collected anonymously via Google Form and included the Mental Strength Scale, Brief Resilience Scale, Grit Scale, General Self-Efficacy Scale, Brief Self-Control Scale, Brief Aggression Questionnaire, Satisfaction with Life Scale, Mental Health …

Examining The Effects Of An Isbarr Educational Intervention On Self-Efficacy Of Senior-Level Nursing Students Within A Transition To Practice Course: A Quasi-Experimental Study, Stacy Nicole Taylor

Doctoral Dissertations and Projects

The purpose of this study was to examine the effects of an introduction, situation, background, assessment, requests/recommendations, and repeatback/readback (ISBARR) educational intervention on self-efficacy of senior-level nursing students' within a Transition to Practice course at one Christian university in the southeast United States. The theoretical framework utilized in this study was Bandura's theory of self-efficacy. This study was a quasi-experimental design with a control and intervention group. The control group was in the Fall 2023 semester, and the intervention group was in the Spring 2024 semester. Each participant completed a pre-test and post-test, which was the New Generalized Self-Efficacy Scale. …

Improving Use Of Water Immersion And Birth Satisfaction During The First Stage Of Labor Through An Educational Handout, Dana E. Taylor

Doctoral Dissertations and Projects

Although using the birthing tub for hydrotherapy during the first stage of labor has been proven to be a safe and effective method of low-intervention pain management, as well as research that indicates potential other benefits such as a reduction in the use of an epidural, improvement in breastfeeding rates, and promotion of physiologic birth, its use is often limited. Chief reasons for the lack of its use include difficulty and time constraints with tub set-up and lack of knowledge about its benefits, especially the length of time used. A quasi-experimental evidence-based project at a suburban magnet-designated hospital using a …

Bronchoalveolar Lavage Neutrophils And Matrix Metalloproteinase-9 In Sarcoidosis Clinical Phenotypes: Implications For Tissue Remodeling Leading To Pulmonary Fibrosis, Rafael L. Perez, Md, Jeff Ritzenthaler, E. Torres-Gonzalez, Prarthna Chandar, Md, Daniel Kramer, Md, Jesse Roman, Md

Division of Pulmonary, Allergy, and Critical Care Medicine Posters

Introduction

Pulmonary sarcoidosis may resolve or progress to advanced stages. Increased lung neutrophils obtained by bronchoalveolar lavage are found in advanced pulmonary sarcoidosis. Persistence of a neutrophilic alveolitis has been postulated to result in tissue injury and remodeling that leads to fibrosis and clinical features of advanced disease. Since neutrophils are a source of matrix-degrading proteins like matrix metalloproteinases (MMPs), we hypothesized that PMNs promote disease progression through the release of MMPs. This work explores the relationship between lung neutrophils and MMP9 levels and activity and how they are associated with sarcoidosis clinical phenotypes.

Assessing Dental Hygiene Students’ Perspectives: A Survey Of Curriculum Adequacy For Interdisciplinary Settings In U.S. Dental Hygiene Programs, Brittany Elaine Tripp

Dental Hygiene ETDs

This study investigated whether dental hygiene programs implement interdisciplinary care into their curriculum and assessed student preparedness for working in interdisciplinary settings. The study also aimed to identify student preferences for various interdisciplinary care settings. A survey was developed and distributed via email to program directors of accredited dental hygiene programs across the United States. Those programs directors were asked to forward the survey to currently enrolled final-year students. Out of eighty-two responses received, 16 were excluded because those respondents were not final-year dental hygiene students. Sixty-six participants were considered eligible for the survey (n=66). The results indicate that most …

Dental Hygiene Program Admission Criteria Key Indicators To National Board Success, Kacy Goetz

Dental Hygiene ETDs

The study evaluates the admission criteria of entry-level dental hygiene programs in the United States and their relationship to National Dental Hygiene Board Examination (NDHBE) success rates. An online survey was distributed to 327 programs, gathering data on admission criteria and NDHBE outcomes through a 16-question Microsoft Forms survey. With a response rate of 16% (53 respondents), the survey found that GPA was the most common admission criterion used by 92% of programs. The results indicated a strong negative correlation between high school GPA and NDHBE success. The study also evaluated NDHBE pass rates with board review courses taken. The …

“We Rely On Each Other”: A Qualitative Exploration Of Rural Eastern Region Native American Experiences During The Covid-19 Pandemic, Robin M. Dawson Phd, Rn, Cpnp-Pc, Hunter M. Boehme, Stephen Criswell Ph.D., Julia Dunham-Thornton, Melissa S. Nolan Ph.D., Mph

Publications

Background: Native American communities suffered disproportionately negative effects during the COVID-19 pandemic, yet no research has explored the experiences of rural Eastern Region Native Americans. Methods: Informed by the Native Reliance Model and Indigenous Standpoint Theory, we conducted a qualitative descriptive project in the Spring and Summer of 2022; data included semi-structured interviews and focus groups with 24 individuals representing five South Carolina tribal groups. Findings: Thematic analysis yielded four emergent themes: 1) “Let's just finish the Indians off”: Pandemic distrust rooted in historical and contemporary Native American experiences; 2) “We have been misled”: Making sense of conflicting public health …

Impact Of Efavirenz On Hormone-Positive Breast Cancer Survival In Women Living With Hiv, Arthur T Johnson, Taolo Ntloedibe, Jose Euberto Mendez Reyes, Mogomotsi S Matshaba, Scott L Dryden-Peterson, Elizabeth Y Chiao

Center for Medical Ethics and Health Policy Staff Publications

Women living with HIV and breast cancer have poorer survival than HIV-negative women. Efavirenz-estrogen interactions are documented; however, the survival impact is unknown. Survival between women with estrogen-receptor positive breast cancer taking efavirenz (n = 38) and nonefavirenz regimens (n = 51) were compared. The 5-year overall-survival was 48.9% [95% confidence interval (CI) 33.0-72.2 and 51.1% (95% CI 34.0-76.8)] in the efavirenz and nonefavirenz groups, respectively suggesting efavirenz is unlikely driving poorer survival in women living with HIV and estrogen-receptor positive breast cancer.

Early Depletion Of Gut Microbiota Shape Oligodendrocyte Response After Traumatic Brain Injury, Kirill Shumilov, Allen Ni, Maria Garcia-Bonilla, Marta Celorrio, Stuart H Friess

2020-Current year OA Pubs

BACKGROUND: This study is a cost-effectiveness study of two implementation strategies designed to train therapists in college and university counseling centers to deliver interpersonal psychotherapy. Costs of implementing a train-the-trainer (TTT) strategy versus an expert consultation strategy were estimated, and their relative effects upon therapist outcomes were calculated and compared.

METHODS: Twenty four counseling centers were recruited across the United States. These centers were randomized to either a TTT (experimental) condition, in which an in-house therapist trained other center therapists, or an expert consultation condition, in which center therapists participated in a workshop and received 12 months of ongoing supervision. …

Improving Hypertension Control In Nigeria: Early Policy Implications From The Hypertension Treatment In Nigeria Program, Oluwabunmi Ogungbe, Chibuzor Abasilim, Mark D Huffman, Dike Ojji, Hypertension Treatment In Nigeria Program Team

2020-Current year OA Pubs

Hypertension poses a significant health burden globally. In Nigeria, hypertension prevalence is on the rise, with low rates of awareness, treatment, and control. This policy brief explores the critical gaps addressed by the Hypertension Treatment in Nigeria (HTN) Program, highlighting its strengths, initial outcomes, and scalability in primary care settings. The HTN Program employs an integrated, multilevel care model based on the World Health Organization's HEARTS technical package, including patient registration and empanelment, team-based care, training and supervision, a standardized treatment protocol, a health information management system, and a drug revolving fund to improve medication accessibility. By December 2023, hypertension …

Novel Immunomodulatory Properties Of Adenosine Analogs Promote Their Antiviral Activity Against Sars-Cov-2, Giulia Monticone, Zhi Huang, Peter Hewins, Thomasina Cook, Oygul Mirzalieva, Brionna King, Kristina Larter, Taylor Miller-Ensminger, Maria D. Sanchez-Pino, Timothy P. Foster, Olga V. Nichols, Alistair J. Ramsay, Samarpan Majumder, Dorota Wyczechowska, Darlene Tauzier, Elizabeth Gravois, Judy S. Crabtree, Jone Garai, Li Li, Jovanny Zabaleta, Mallory T. Barbier, Luis Del Valle, Kellie A. Jurado, Lucio Miele

School of Medicine Faculty Publications

The COVID-19 pandemic reminded us of the urgent need for new antivirals to control emerging infectious diseases and potential future pandemics. Immunotherapy has revolutionized oncology and could complement the use of antivirals, but its application to infectious diseases remains largely unexplored. Nucleoside analogs are a class of agents widely used as antiviral and anti-neoplastic drugs. Their antiviral activity is generally based on interference with viral nucleic acid replication or transcription. Based on our previous work and computer modeling, we hypothesize that antiviral adenosine analogs, like remdesivir, have previously unrecognized immunomodulatory properties which contribute to their therapeutic activity. In the case …

Rare Causes Of Gastrointestinal Hemorrhage: A Case Series Of Adult Duodenal And Jejunal Gastric Heterotopia, Venkata Vinod Matli, John Kirkikis, Gregory Wellman, Dustin Hadley, Ross M. Dies, David F. Dies

School of Medicine Faculty Publications

Gastric heterotopia (GH) is a rare cause of gastrointestinal bleeding. GH of the small bowel is rare, and the duodenum is more commonly involved than the jejunum. Here, we present five cases of GH involving the duodenum and jejunum, with presentations including gastrointestinal bleeding, symptomatic anemia, and no symptoms. A 63-year-old man presented with melenic stools but could not identify an obvious bleeding source during endoscopy. He was ultimately diagnosed with jejunal GH. A 70-year-old woman with melena and severe anemia had a duodenal bulb mass detected during endoscopy, which was histopathologically diagnosed as GH. A 54-year-old woman experienced nausea, …

Developing Public-Private R&D Consortia To Accelerate Alzheimer’S Disease Drug Development, Joel West, Paul Olk

Management: Faculty Scholarship

Efforts to accelerate Alzheimer's disease (AD) drug development have been spurred on by the creation of open science, public-private R&D consortia. An R&D consortium provides an improved structure for generating and disseminating AD knowledge across a range of organizations while also aligning their interests. Drawing from archival and interview data collected on 46 public-private R&D consortia focused wholly or in part on AD, we uncover two important innovations: the creation of novel consortium types that facilitate coordination beyond the individual consortium, and the practice of organizations joining multiple consortia. Collectively these innovations provide member organizations with different pathways for advancing …

The Potential Anti-Arrhythmic Effect Of Sglt2 Inhibitors, Hong-Yi Duan, Hector Barajas-Martinez, Charles Antzelevitch, Dan Hu

Department of Medicine Faculty Papers

Sodium-glucose cotransporter type 2 inhibitors (SGLT2i) were initially recommended as oral anti-diabetic drugs to treat type 2 diabetes (T2D), by inhibiting SGLT2 in proximal tubule and reduce renal reabsorption of sodium and glucose. While many clinical trials demonstrated the tremendous potential of SGLT2i for cardiovascular diseases. 2022 AHA/ACC/HFSA guideline first emphasized that SGLT2i were the only drug class that can cover the entire management of heart failure (HF) from prevention to treatment. Subsequently, the antiarrhythmic properties of SGLT2i have also attracted attention. Although there are currently no prospective studies specifically on the anti-arrhythmic effects of SGLT2i. We provide clues from …

Anticoagulation Stewardship Initiative For The Outpatient Management Of Atrial Fibrillation, Ryleigh Hawker

Doctoral Dissertations and Projects

Anticoagulation prescribing for patients with atrial fibrillation at a local primary care and urgent care office has largely been conservative and unstandardized, leaving patients at risk for cardioembolic strokes. As more and more patients are diagnosed with this condition, the greater the need becomes for appropriate management within these settings. This includes preventing strokes with anticoagulation and utilizing an integrative or collaborative approach between specialty and non-specialty centers. The Anticoagulation Stewardship Initiative is the first step in promoting effective and safe anticoagulation practices in primary and urgent care centers, while simultaneously streamlining care for newly diagnosed patients. Some of the …

A History Of The Development Of Alternatives To Animals In Research And Testing, John Parascandola

New Directions in the Human-Animal Bond

Growing public interest in animal welfare issues in recent decades has prompted increased attention to the efforts to develop alternative, nonanimal methods for use in biomedical research and product testing. In A History of the Development of Alternatives to Animals in Research and Testing, the first book-length study of the subject, John Parascandola traces the history of the concept of alternatives to the use of animals in research and testing in Britain and the United States from its beginnings until it had become firmly established in the scientific and animal protection communities by the end of the 1980s. This …

Implementation, Enrollment, And Engagement In An Opt-Out Telehealth Pharmacist-Assisted Tobacco Treatment Program For Patients Seen In Oncology Outpatient Clinics, K. Michael Cummings, Benjamin A. Toll, Vincent Talbot, Avery Roberson, Dianne Wilson, Martha Dunlap, Emily C. Ware, Amanda M. Palmer, Asia A. Bliss, Vincent S. Anokye, Graham Warren

Markey Cancer Center Faculty Publications

OBJECTIVE: To describe the workflow, reach, cost, and self-reported quit rates for an opt-out tobacco treatment program (TTP) for patients seen in 43 oncology outpatient clinics.

METHODS: Between May 25, 2021, and December 31, 2022, adult patients (≥18 years) visiting clinics affiliated with the Medical University of South Carolina Hollings Cancer Center were screened for smoking status. Those currently smoking were referred to a telehealth pharmacy-assisted TTP. An attempt was made to contact referred patients by phone. Patients reached were offered free smoking cessation counseling and a 2-week starter kit of nicotine replacement medication. A random sample of 420 patients …

Iron Oxide Nanozymes Enhanced By Ascorbic Acid For Macrophage-Based Cancer Therapy, Zhongchao Yi, Xiaoyue Yang, Ying Liang, Sheng Tong

Markey Cancer Center Faculty Publications

In recent years, using pharmacological ascorbic acid has emerged as a promising therapeutic approach in cancer treatment, owing to its capacity to induce extracellular hydrogen peroxide (H2O 2) production in solid tumors. The H2 O 2 is then converted into cytotoxic hydroxyl free radicals (HO•) by redox-active Fe2+ inside cells. However, the high dosage of ascorbic acid required for efficacy is hampered by adverse effects such as kidney stone formation. In a recent study, we demonstrated the efficient catalytic conver- sion of H2 O2 to HO• by wüstite (Fe 1−xO) nanoparticles (WNPs) through a heterogenous Fenton reaction. Here, we explore …

Variations Of Inflammatory Markers Levels (Esr And Crp) In The Perioperative Period Of Total Knee Arthroplasty, Khalil Ibrahim Sadiq, Mohamedbakir Abbas Abdulzahra, Rafid Mousa Jaffar

Iraqi National Journal of Medicine

Background: The preferred method of treatment for severe osteoarthritis of the knee is total knee arthroplasty (TKA). TKA has been linked to a significant increase in inflammatory markers such as erythrocyte sedimentation rate (ESR)—a test that measures how quickly red blood cells settle to the bottom of a test tube—and C-reactive protein (CRP)—a protein made by the liver that increases when there’s inflammation in the body. Aim: Assessment of the typical time trend and physiological kinetics of CRP and ESR during the early postoperative period over 4 weeks Methods: The study was conducted in the Basrah arthroplasty center, from June …

The Role Of Sexual Network Core Groups In Disease Epidemics, Jason Janeaux

LSU Doctoral Dissertations

Sexually transmitted infections (STIs) remain an economic and social burden, non-discriminately affecting sexually active individuals worldwide. The unique transmission of STIs is dependent upon host and pathogen life histories, as well as the underlying network structure of the host population. Within a population there is a group of individuals, the core group, that maintains STI presence and helps sustain ongoing transmission both within the core group and in the surrounding population. While the presence of these core groups is well documented, the criteria for inclusion into a sexual core group is not. In this dissertation, I explore common factors that …

Systemic Interindividual Dna Methylation Variants In Cattle Share Major Hallmarks With Those In Humans, Wen-Jou Chang, Maria S Baker, Eleonora Laritsky, Chathura J Gunasekara, Uditha Maduranga, Justine C Galliou, Joseph W Mcfadden, Jessica R Waltemyer, Bruce Berggren-Thomas, Brianna N Tate, Hanxue Zhang, Benjamin D Rosen, Curtis P Van Tassell, George E Liu, Cristian Coarfa, Yi Athena Ren, Robert A Waterland

Faculty, Staff and Students Publications

BACKGROUND: We recently identified ~ 10,000 correlated regions of systemic interindividual epigenetic variation (CoRSIVs) in the human genome. These methylation variants are amenable to population studies, as DNA methylation measurements in blood provide information on epigenetic regulation throughout the body. Moreover, establishment of DNA methylation at human CoRSIVs is labile to periconceptional influences such as nutrition. Here, we analyze publicly available whole-genome bisulfite sequencing data on multiple tissues of each of two Holstein cows to determine whether CoRSIVs exist in cattle.

RESULTS: Focusing on genomic blocks with ≥ 5 CpGs and a systemic interindividual variation index of at least 20, …

Transcriptomic Analysis Reveals The Anti-Cancer Effect Of Gestational Mesenchymal Stem Cell Secretome, Salvatore Vaiasicca, Gianmarco Melone, David W James, Marcos Quintela, Jing Xiao, Seydou Yao, Richard H Finnell, Robert S Conlan, Lewis W Francis, Bruna Corradetti

Faculty, Staff and Students Publications

The environment created during embryogenesis contributes to reducing aberrations that drive structural malformations and tumorigenesis. In this study, we investigate the anti-cancer effect of mesenchymal stem cells (MSCs) derived from 2 different gestational tissues, the amniotic fluid (AF) and the chorionic villi (CV), with emphasis on their secretome. Transcriptomic analysis was performed on patient-derived AF- and CV-MSCs collected during prenatal diagnosis and identified both mRNAs and lncRNAs, involved in tissue homeostasis and inhibiting biological processes associated with the etiology of aggressive cancers while regulating immune pathways shown to be important in chronic disorders. Secretome enrichment analysis also identified soluble moieties …