Medicine and Health Sciences Commons^™

A Rare Case Of A Malignant Proliferating Trichilemmal Tumor: A Molecular Study Harboring Potential Therapeutic Significance And A Review Of Literature, Mokhtar H Abdelhammed, Hanna Siatecka, A Hafeez Diwan, Christie J Finch, Angela D Haskins, David J Hernandez, Ya Xu

Faculty, Staff and Students Publications

Malignant proliferating trichilemmal tumors (MPTTs), arising from the external root sheath of hair follicles, are exceptionally rare, with limited documentation of their genetic alterations. We present a case of a 64-year-old African American woman who initially presented with a gradually enlarging nodule on her posterior scalp. An initial biopsy at an outside hospital suggested metastatic adenocarcinoma or squamous cell carcinoma (SCC) of an uncertain origin. A subsequent wide local excision revealed a 2.0 cm tumor demonstrating characteristic trichilemmal keratinization, characterized by an abrupt transition from the nucleated epithelium to a laminated keratinized layer, confirming MPTT. Immunohistochemistry demonstrated diffuse p53 expression, …

Imlunestrant, An Oral Selective Estrogen Receptor Degrader, As Monotherapy And In Combination With Targeted Therapy In Estrogen Receptor-Positive, Human Epidermal Growth Factor Receptor 2-Negative Advanced Breast Cancer: Phase Ia/Ib Ember Study, Komal L Jhaveri, Cynthia X Ma, Et Al.

2020-Current year OA Pubs

PURPOSE: Imlunestrant is a next-generation oral selective estrogen receptor (ER) degrader designed to deliver continuous ER target inhibition, including in

METHODS: An i3+3 dose-escalation design was used, followed by dose expansions of imlunestrant as monotherapy or in combination with abemaciclib with or without aromatase inhibitor (AI), everolimus, or alpelisib. Imlunestrant was administered orally once daily and with the combination partner per label.

RESULTS: Overall, 262 patients with ER+/HER2- ABC were treated (phase Ia, n = 74; phase Ib, n = 188). Among patients who received imlunestrant monotherapy (n = 114), no dose-limiting toxicities or discontinuations occurred. At the RP2D (400 …

Prenatal Social Disadvantage Is Associated With Alterations In Functional Networks At Birth, Ashley N Nielsen, Regina L Triplett, Lourdes M Bernardez, Ursula A Tooley, Max P Herzberg, Rachel E Lean, Sydney Kaplan, Dominique Meyer, Jeanette K Kenley, Dimitrios Alexopoulos, David Losielle, Aidan Latham, Tara A Smyser, Arpana Agrawal, Josh S Shimony, Joshua J Jackson, J Philip Miller, Marcus E Raichle, Barbara B Warner, Cynthia E Rogers, Chad M Sylvester, Deanna M Barch, Joan L Luby, Christopher D Smyser

2020-Current year OA Pubs

Childhood exposure to social disadvantage is a major risk factor for psychiatric disorders and poor developmental, educational, and occupational outcomes, presumably because adverse exposures alter the neurodevelopmental processes that contribute to risk trajectories. Yet, given the limited social mobility in the United States and other countries, childhood social disadvantage is frequently preceded by maternal social disadvantage during pregnancy, potentially altering fetal brain development during a period of high neuroplasticity through hormonal, microbiome, epigenetic, and immune factors that cross the placenta and fetal blood-brain barrier. The current study examines prenatal social disadvantage to determine whether these exposures in utero are associated …

Impact Of Prior Inotuzumab Ozogamicin Treatment On Brexucabtagene Autoleucel Outcomes In Adults With B-Cell All, Ibrahim Aldoss, Gregory W Roloff, Rawan Faramand, Noam E Kopmar, Chenyu Lin, Anjali S Advani, Simone E Dekker, Vishal K Gupta, Timothy E O'Connor, Nikeshan Jeyakumar, Ibrahim N Muhsen, Yannis Valtis, Amy Zhang, Katharine Miller, Katherine Sutherland, Kaitlyn C Dykes, Mohamed Ahmed, Evan Chen, Hector Zambrano, Danielle Bradshaw, Santiago Mercadal, Marc Schwartz, Sean Tracy, Bhagirathbhai Dholaria, Michal Kubiak, Akash Mukherjee, Navneet Majhail, Minoo Battiwalla, Luke Mountjoy, Shahbaz A Malik, John Mathews, Paul Shaughnessy, Aaron C Logan, Abdullah Ladha, Maryann Stefan, Caitlin Guzowski, Rasmus T Hoeg, Talal Hilal, Jozal Moore, Matthew Connor, Kristen M O'Dwyer, Laquisa C Hill, Stephanie B Tsai, Joshua Sasine, Melhem M Solh, Catherine J Lee, Vamsi K Kota, Divya Koura, Muthu Veeraputhiran, Betsy Blunk, Caspian Oliai, Jessica T Leonard, Noelle V Frey, Jae H Park, Marlise R Luskin, Veronika Bachanova, Ahmed Galal, Michael R Bishop, Wendy Stock, Ryan D Cassaday, Vinod Pullarkat, Bijal D Shah, Lori S Muffly

Faculty, Staff and Students Publications

The effect of prior inotuzumab ozogamicin (InO) treatment on brexucabtagene autoleucel (brexu-cel) outcomes remains unclear in adults with acute lymphoblastic leukemia (ALL). We conducted a retrospective multicenter analysis of 189 patients with relapsed/refractory ALL treated with brexu-cel. Over half of the patients received InO before brexu-cel (InO exposed). InO-exposed patients were more heavily pretreated (P = .02) and frequently had active marrow disease before apheresis (P = .03). Response rate and toxicity profile after brexu-cel were comparable for InO-exposed and InO-naïve patients; however, consolidation therapy after brexu-cel response was used at a higher rate in InO-naïve patients (P = .005). …

Multidisciplinary Travel Health Education: Current Status And Rationale For Standardized Competencies, Karl M Hess, Sheila M Seed, Eva H Clark, Tara Lombardo, Francesca F Norman, Gerard Flaherty

Faculty, Staff and Students Publications

This perspective highlights the inconsistent integration of travel health education across medical, nursing and pharmacy educational programmes globally and calls for standardized travel health competencies based on the International Society of Travel Medicine’s (ISTM) Body of Knowledge to help improve patient care outcomes as global travel returns to pre-pandemic levels.

Oligosaccharides, Onion Peel, And Essential Oils As Feed Additives In The Diet Of Dairycattle: In Vitro Fermentation, Greenhouse Gases, Ruminal Nutrient Degradability, Andvolatile Fatty Acid Production, Kelechi A. Ike, Oludotun O. Adelusi, Joel O. Alabi, Lydia K. Olagunju, Michael Wuaku, Chika C. Anotaenwere, Deborah O. Okedoyin, Oluteru E. Orimaye, Deandrea Gray, Peter A. Dele, Kiran Subedi, Ahmed E. Kholif, Uchenna Y. Anele

Turkish Journal of Veterinary & Animal Sciences

This study investigated the effect of inclusion of dietary oligosaccharides, onion peel, and an essential oil blend (EOB; containing anise, clove, oregano, cedarwood, and ginger in the ratio 4:2:2:1:1) individually and in combinations in the total mixed ration of dairy cattle on in vitro gas production (GP), dry matter disappearance (DMD), fiber fraction disappearance, and total and individual volatile fatty acid (VFA) production. EOB was used at 200 μL g–1 of feed while the other additives were administered at 3% of the feed on a dry matter basis. The in vitro batch culture technique was used for this experiment and …

Response Of Mucinous Breast Carcinoma To Neoadjuvant Chemotherapy, Berkay Kiliç, Burak İlhan

Turkish Journal of Medical Sciences

Background/aim: Mucinous breast carcinoma (MC) is thought to be a favorable-differentiated form of invasive breast cancer and is rarely preferred for neoadjuvant chemotherapy (NAC). The study aimed to define the response of MCs to NAC.Materials and methods: The study reviewed the demographic, clinicopathologic characteristics, management, and follow-up data of 70 patients diagnosed with MC between May 2010 to December 2020 by examining patients’ historical files and oncology records.Results: The median age, tumor size, and follow-up period of patients were respectively 52.9 (range 32 to 87) years, 25.8 (range 8 to 88) mm, and 61.5 (range 18 to 143) months. Out …

The Relationship Between Drug Induced Immunogenicity And Hypersensitivity Reactions And Skin Tests Related To Infliximab, Etanercept And Adalimumab In Patients With Rheumatoid Arthritis And Ankylosing Spondylitis, Alper Doğanci, Şebnem Ataman, Ali̇ Özdemi̇rel, Recep Seçki̇n, Ayşe Yalçin, Sevi̇m Bavbek

Turkish Journal of Medical Sciences

Background and aim: We aimed to investigate the relationship between serum anti-drug antibody (ADAb), hypersensitivity reactions (HSRs) to anti-tumor necrosis factors (anti-TNFs) drugs and to detect the role of skin tests in the diagnosis of HSRs against anti-TNFs.Material and methods: 69 ankylosing spondilitis (AS) and 46 rheumatoid artritis (RA) patients using infliximab, adalimumab, and etanercept were enrolled. Disease activity scores for AS and RA patients were assessed. Serum levels of anti-TNFs and ADAb to these agents were measured with the ELISA.These blood samples were taken 24 hours before the next drug dose.The patients with anti-TNF-associated HSRs were evaluated with a …

High Sacral Slope, Lumbar Lordosis, And Sacral Slope-To-Pelvic Incidence Ratio Are Associated With New Bone Formation In Ankylosing Spondylitis, Aysun Aksoy, Cemal Gündoğmuş, Mehmet Kesi̇mer, Kemal Nas, İkram Duman, Gazanfer Eki̇nci̇, Murat Bezer, Pami̇r Atagündüz

Turkish Journal of Medical Sciences

Background/aim: Syndesmophyte formation appears to be site specific in Ankylosing spondylitis(AS),and new bone formation seems to occur in regions of micro-trauma that are prone to tensile forces.Pelvic and spinal parameters are unique for individuals. Pelvic tilt and sacral slope are important anatomical features that compensate in harmony in keeping the sagittal balance. After puberty, the sacral slope shapes the lumbar lordosis, whereas the pelvic incidence is set to an individual constant. This study aims to analyze the properties of pelvic parameters in AS patients with and without syndesmophyte formation in the spine after 15years of disease duration.Materials and methods:Whole spine …

Comparison Of Rigid And Elastic Registration Methods In Software-Based Targeted Prostate Biopsy: A Multi-Center Cohort Study, Serhat Çeti̇n, Serdar Çeli̇k, Murat Koparal, Güven Aslan, Sertaç Yazici, Bahadir Şahi̇n, Si̇nan Sözen, Levent Türkeri̇

Turkish Journal of Medical Sciences

Background/Aim: This study aims to compare the success rates of rigid registration (RR) and elastic registration (ER)systems in diagnosing all cancers and clinically significant prostate cancer (csPC) in software-based targeted prostate biopsies (TPBs) by performing matching analysis.Materials and Methods: The data of 2,061 patients from six centers where software-based TPB was performed were used. All cancer and csPC detection rates of the RR and ER systems were compared following Mahalanobis distance matching within the propensity score caliper method. Logistic regression analysis was applied to identify factors predicting clinically insignificant prostate cancer (ciPC) and csPC diagnoses. Additionally, the International Society of …

Evaluation Of The Relationship Between Type Of Menopause And Cognitive Functions, Meltem Durakli Ulukök, Ufuk Atlihan, Onur Yavuz

Turkish Journal of Medical Sciences

Background/aim:Menopause is often accompanied by neurological symptoms, including cognitive difficulties, especially with memory and attention. In the present study, the purpose was to examine the relationship between the timing of menopause and the cognitive performance of menopausal patients who applied to our neurology clinic with complaints of forgetfulness.Materials and methods: The data of 538 women who applied to the neurology clinic with complaints of forgetfulness between January 2018 and January 2024and underwent neuropsychological evaluations were scanned retrospectively. A total of 96 patients who applied to neurology and menopause clinics were included in the study.Results: In the present study, attention orientation, …

Exploring Patients' Views Regarding The Support And Rehabilitation Needs Of People Living With Myocardial Ischaemia And No Obstructive Coronary Arteries: A Qualitative Interview Study, Helen Humphreys, Danielle Paddock, Sarah Brown, Aynsley Cowie, Colin Berry, Susan Dawkes, Simon Nichols

Research outputs 2022 to 2026

OBJECTIVES: This study aimed to generate new qualitative insights to understand the rehabilitation needs of people living with a confirmed or presumed diagnosis of ischaemia with no obstructive coronary arteries (INOCA), explore which aspects of current cardiovascular prevention and rehabilitation programmes could meet the needs of people with INOCA and where adjustments (if any) may be appropriate. DESIGN: Semistructured qualitative interview study. PARTICIPANTS: Interviews were undertaken (n=17; 88% female, age range 31-69 years) with people with a confirmed or presumed diagnosis of INOCA. RESULTS: Findings highlighted concerns around a lack of evidence-based guidance for cardiovascular prevention and rehabilitation programmes for …

A Survey Of Root Canal Treatment In Kurdish Community: A Pilot Study, Adil Othman Abdullah

Polytechnic Journal

Objective To analyze and describe the techniques and procedures employed in root canal treatment in the Kurdistan Region.

Method This study was conducted in 2023 and involved a simple random sample of 210 dentists/endodontists practitioners. The survey was spread throughout both private and governmental sectors in three distinct locations within the Kurdistan Region. The study aimed to enhance dentists' awareness and knowledge of the latest devices and advanced techniques used in the field of endodontics. The data were evaluated using basic summary statistics.

Results The eighty seven percentage of the practitioners responded. The majority of participants reported using step-back instrumentation …

Physician Assistant Students As Agents Of Change Through Service-Learning Opportunities, Kelli Frost ,Ms, Pa-C, Nour Lyon ,Ms, Pa-C, Arthur Ko ,Phd, Claire Barry ,Pa-S, Michael Martin ,Mals

Jesuit Higher Education: A Journal

Community outreach and the integration of cultural competency are essential to the education and development of healthcare professionals. This article describes incorporating service-learning into a course at a Jesuit and Mercy institution as a method of building cultural competency into a Physician Assistant (PA) curriculum. The project examined how service-learning impacted students’ understanding of community needs and allowed students to reflect on their values. In addition, it aimed to inspire students to build connections with vulnerable populations and have concern for the poor and marginalized. Students participated in service opportunities with a community partner to identify and meet the needs …

Gender Segregation In Caring Labor: The Impact Of Social Norms On Career Choices, Evelyn Xinhui Cheng

CBER Conference

Women engage in work stereotypically seen as "women's work," or work based on the perceived "natural" female tendency towards caring and relational thinking (Tung 2000). In pre-reform China, Shu (2005) found that women were more concentrated in the lowerpaying collective sector compared to men in the state-owned sector, contributing to the gender wage gap. China's horizontal occupational segregation by gender has significant implications for gender pay gaps, workforce attachment, and the perceived value of caring labor in society. Feminist scholars argue that gendered norms around caring originate that conflate womanhood with nurturing (England 2005; Litt & Zimmerman 2003). The main …

Impact Of Pathogenic E. Coli In Drinking Water On The Well-Being Of Children, Aysha Khatoon

CBER Conference

Despite global advancements, unsafe drinking water is a major cause of illness, ranked as the eighth highest worldwide (Forouzanfar et al., 2015). Studies indicate that even improved water sources, can harbour faecal contamination (Shaheed et al., 2014; Bain et al., 2014b). Globally, 1.8 billion people rely on drinking water contaminated with faecal matter (Bain et al., 2014a), with pathogenic E. coli being a primary concern. In Pakistan, the situation is dire. About 25 million people, particularly children, suffer due to open defecation, leading to 53,000 child deaths annually from diarrhoea (UNICEF, 2021). Pathogenic E. coli is a significant contributor to …

Enhancing Disaster Response Competencies In Nursing Education Through Simulation-Based Training: An Integrated Literature Review, Paul Dreater

DNP Qualifying Manuscripts

Objectives: This integrated literature review aimed to identify and prioritize disaster management education content to equip undergraduate and graduate nursing students with the necessary knowledge and skills for competent disaster response.

Data sources and review method: A literature search was conducted across multiple databases, including Cochrane, CINAHL, PsycINFO, PubMed, Google Scholar, Fusion, and Scopus, using keywords such as disaster nursing, disaster preparedness, simulation, education, and mass casualty incidents. Filters restricted results to English-language studies from the past ten years within nursing education. Selected articles were reviewed and summarized to address the research question: What are the essential disaster …

Improving Diabetes Self-Management Skills Among Adults With Type 2 Diabetes Through Weekly Education, Carthia Joachim

Dissertations

Type 2 Diabetes Mellitus is one of the major health issues worldwide, which has led to many health complications, such as cardiovascular disease, nerve damage that leads to limb amputation, kidney damage, and even death (Sameer et al., 2020). Lack of self-care management is one of the reasons diabetes is becoming such an issue in society. Studies have shown that T2DM outcomes can be improved by implementing diabetes self-management education (DSME) (Hailu et al., 2019). The study evaluated the effectiveness of DSME intervention in adult patients with T2DM over 12 weeks in Orlando, Florida. Using a structured education program, the …

The Physical And Psychological Impacts Of Exercise On Hypermobile Ehlers-Danlos Syndrome: A Case Study, Savannah Posey

Honors Projects

Hypermobile Ehlers-Danlos Syndrome (hEDS) is a subtype of a series of connective tissue disorders identified by joint hypermobility and multisystemic symptoms. It is caused by a lack of collagen production affecting the body’s ability to support important structures such as muscle, bone skin, and other connective tissues. To study the physical and psychological impacts of exercise on hypermobile Ehlers-Danlos Syndrome, a seven-week, phased exercise intervention program was implemented for a nineteen-year-old male with the disease. The program consisted of three phases focused on the strengthening of the surrounding musculature of the glenohumeral joint, along with improving muscular endurance and proprioception. …

Ada News - 12/09/2024, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.

Intouch Week Of December 9, 2024, New York Medical College

InTouch

• NYMC Donors Make an Impact This Giving Tuesday
• Medical Students Inspire Youth During Black Men in White Coats Summit
• 29th Annual MSRF Set for December 13
• GSBMS Celebrates Friendsgiving
• NYMC Alumni/Student Fall Mixer Builds Connections and Professional Insights
• Human Milk for Extreme Preemies: A Kosher Option
• Artificial Intelligence Can Revolutionize Acute Stroke Care
• Design the Next NYMC T-Shirt
• NYMC and TU Hosts “Ninety Minutes: The Medical Magazine of the Web”
• In The Community: GSA 5K Raises Awareness for Food Insecurity, Fundraising Continues
• Faculty Spotlight: From Pupil to Professor: Alumni Lighting the Way at NYMC

Examining The Effects Of Language Barriers For Non-Native English Speakers In The Healthcare System In Northwest Ohio, Sarah Witt

Honors Projects

Hundreds of thousands of people in the state of Ohio speak a language other than English, and communication in a predominantly English-speaking state can prove not only cumbersome, but dangerous as well. Patients who have difficulties communicating with their healthcare providers experience higher rates of medical error, adverse medical reactions because of improper drug use, longer hospital stays, and more hospital readmissions than the general population. Additionally, they experience high rates of anxiety and frustration when receiving medical care, which causes resentment and mistrust of the healthcare system. This study investigated language barriers in healthcare systems across Northwest Ohio by …

H. H. Holmes: Savage Monster Or Cruel Conman?, Max Ewoldt

Bakerman Student Research Awards

No abstract provided.

Enhancing Disaster Preparedness In Nursing Education: A Quality Improvement Approach Using Simulation And Training, Paul Dreater

Doctor of Nursing Practice (DNP) Projects

Background: Natural or artificial disasters threaten safety and continuity in educational settings. The University of San Francisco School of Nursing and Health Professions (USF SONHP) identified a critical gap in its disaster preparedness, underscored by the absence of a comprehensive disaster plan. This shortfall highlights the need for an educational strategy encompassing disaster readiness and response, particularly given the potential for such events to cause substantial harm and disruption.

Local Problem: A gap analysis conducted at the USF SONHP revealed the lack of a structured disaster plan, underlining the urgent need for an initiative to develop and implement a comprehensive …

High Intracranial Pressure Following Endoscopic Third Ventriculostomy: Illustrative Case, Zachary Sokol, Rohan V. Gupta, Robert Ziechmann, Scott R. Shepard

Jefferson Hospital Staff Papers and Presentations

BACKGROUND: Endoscopic third ventriculostomy (ETV) is an effective procedure for the treatment of triventriculomegaly associated with aqueductal stenosis. However, some patients can develop severe and symptomatic intracranial pressure (ICP) elevations in the immediate postoperative period that can be monitored and treated with external ventricular drain (EVD) placement and controlled cerebrospinal fluid (CSF) diversion until the ICP normalizes and symptoms resolve.

OBSERVATIONS: The authors describe the case of a 39-year-old male who underwent ETV and intraoperative EVD placement for obstructive hydrocephalus associated with aqueductal stenosis. The patient was noted to have sustained ICP elevations in the immediate perioperative period but ultimately …

Access To Virtual Care In Behavioral Health: A Social Determinant Of Health, Patrick J. Hearle, Emily A. Smith, Richard J. Caplan, Ram A. Sharma

SKMC Student Presentations and Publications

Abstract Objective: In the wake of COVID-19, the use of virtual modalities to provide healthcare has increased significantly. While virtual care services, particularly for behavioral health encounters, have become commonplace in many healthcare systems, there is limited data describing to what extent access to virtual care is affected by social determinants of health. The present study aims to characterize the utilization of virtual (video, phone) and non-virtual (in—person office visits) behavioral health care encounters among differing socioeconomic and demographic populations in two campuses served by a tertiary care center in Delaware to identify trends and potential barriers to these services. …

12.09.2024 Orsp Connect, Liz Williamson

ORED Newsletter

Employee Profiles

In Person Account Reconciliation and Tableau Training

NSF Proposals with Consultant or Professional Services

Delirium Screening Practices For Older Adults In Emergency Departments Across United States: A Scoping Review, Azmat Sidhu, Joy K. Luzingu, Sheneil Agyemang, Arushi M. Chalke, Grace M. Leito, Joseph A. Molina, Zhao Chen, Deborah Jean Mcclelland, Nimit Agarwal, Leah Steckler, Angela Wu

Journal of Geriatric Emergency Medicine

Delirium is commonly missed among older patients in the Emergency Department (ED). Identifying and managing patients with delirium in ED is critical to help improve health outcomes and prevent falls and readmission. There are several validated delirium screening tools but their utilization for assessing delirium in emergency department settings are still under investigation. The overall purpose of this review was to summarize information on current screening practices for delirium among older adults (65 or older) in EDs across United States and to identify current gaps in knowledge and evidence to help inform future research and practice. A comprehensive literature search …

A Multifactorial Fall Prevention Program, Virale Patel, Zeida Gutierrez

Fall 2024 OTD Capstone Symposium

Falls among older adults are a pressing public health concern, leading to significant physical, psychological, and economic consequences. This capstone project aimed to design and implement a multifactorial fall prevention program to address unmet occupational needs and enhance safety and occupational participation among long-term care residents at a skilled nursing facility. The six-week program included targeted weekly sessions focusing on behavior modification, footwear safety, adaptive equipment training, strength and balance exercises, toileting strategies, and environmental modifications. Pre- and post-program assessments utilized the Fall Efficacy Scale International (FES-I) and participant surveys to evaluate changes in confidence, fear of falling, and satisfaction …

Training Staff Members And Caregivers On Utilizing Allen Cognitive Levels To Aid Individuals Living With Alzheimer's And Dementia To Maintain Activities Of Daily Living, Kristy Boyd, Cassandra Nelson, Jennifer Summers

Fall 2024 OTD Capstone Symposium

This capstone project is about training staff members and caregivers on utilizing the Allen's cognitive levels to aid individuals living with Alzheimer's and dementia to maintain their activities of daily living by creating a program that consists of modules, physical demonstration, and a deliverable for staff members and caregivers as well as therapeutic activities and sensory regulation activities for the participants.