Medicine and Health Sciences Commons^™

Comparing Physiological, Psychological, And Performance Changes Between Myo-Reps Vs Traditional Hypertrophy Protocols, Antonella V. Schwarz

Doctoral Dissertations and Projects

In long-term athlete development, it is common to emphasize hypertrophic adaptations during the beginning training phases prior to focusing on strength and power performance. The purpose of this study was to compare the physiological, psychological, and performance differences between myo-reps (MYO) vs. traditional (TRAD) hypertrophy protocols in trained n=8 male subjects over eight weeks. Current literature suggests hypertrophy may be optimized through 3-6 sets of 6-12 repetitions at 60-80% of one-repetition maximum (IRM) with 1-3 minutes of rest per set. However, alternative hypertrophy protocols such as MYO are underexplored. This quantitative experimental study assessed MYO vs TRAD protocols on hypertrophy …

Virtual Reality Mindfulness For Nursing Stress And Burnout, Rebecca Jean Cantrell

Doctoral Dissertations and Projects

Burnout has been a term that has been researched since the 1970’s; however, it has been noted that throughout the past few years there has been increased burnout amongst healthcare workers. Mindfulness has been researched as a tool to decrease burnout and stress. The delivery of mindfulness activity has been completed through different avenues such as in-person and virtual. The purpose of this research project was to evaluate the effectiveness of virtual reality mindfulness experiences and the burnout rates amongst nursing staff in the ambulatory units of a VA Healthcare System. Six nursing staff members volunteered to participate in the …

The Impact Of Adverse Childhood Experiences On The Eating Behaviors Of Black American Women, Teshia Stovall Dula

Doctoral Dissertations and Projects

This dissertation explores the impact of behaviorism on understanding adverse childhood experiences (ACEs) and their effects on eating behaviors, particularly emotional overeating, and satiety responsiveness, in Black women. It highlights the importance of addressing ACEs to promote holistic well-being, especially given racial health disparities. The study investigates various factors shaping the behavior of Black women, including individual traits, environments, and behavioral patterns, focusing on an under-researched area. It calls for standardized definitions in this context and advocates for more extensive and diverse sample sizes for future research. Ultimately, the research aims to empower Black women by translating insights into effective …

It's Going To Be Okay: Experiences And Perceptions Of People Who Seek Reassurance At Work, Liana Bernard

Dissertations and Theses

This study examined the experiences and perceptions of people who seek reassurance at work using a mixed methods (focus groups and experimental) approach. Reassurance-seeking is an attempt to elicit supportive communication from another person to help one reduce experienced anxiety. First, using focus groups with 32 participants, this study found that people seeking reassurance at work develop complex cognitive structures to reduce the prospective negative impacts of reassurance-seeking behaviors, particularly for those with marginalized identities. Then, in a 3x2 between-person experimental design in which employee gender and reassurance-seeking were manipulated, participants read a transcript of an interaction between an employee …

Diagnostic Power Of Serum Creatinine/Cystatin C Ratio For Identifying Low Mri-Muscle Volume And Low Grip Strength: Data From 9 731 To 149 707 Uk Biobank Older Adults, Ben Kirk, Chia Ling Kuo, Peiran Liu, Meiruo Xiang, Jesse Zanker, Konstantinos Prokopidis, Marc Sim, Richard H. Fortinsky, George A. Kuchel, Gustavo Duque

Research outputs 2022 to 2026

Background: Biomarkers for sarcopenia are lacking. We examined the diagnostic power of serum creatinine to cystatin C ratio for identifying low magnetic resonance imaging-muscle volume and low grip strength in a large observational study of UK Biobank older adults.

Methods: Serum creatinine and cystatin C were measured via immunoassays (Beckman Coulter AU5800 and Siemens Advia 1800, respectively) and grip strength by hydraulic hand dynamometer at baseline visit (2008-2010). magnetic resonance imaging-thigh fat-free muscle volume and DXA-derived appendicular lean mass were measured at imaging visit (2014-2018). Extreme outliers were removed, and covariates (demographic, lifestyle, and clinical factors, as well as time …

Malaria Parasites Require A Divergent Heme Oxygenase For Apicoplast Gene Expression And Biogenesis, Amanda Mixon Blackwell, Yasaman Jami-Alahmadi, Armiyaw S Nasamu, Shota Kudo, Akinobu Senoo, Celine Slam, Kouhei Tsumoto, James A Wohlschlegel, Jose Manuel Martinez Caaveiro, Daniel E Goldberg, Paul A Sigala

2020-Current year OA Pubs

Malaria parasites have evolved unusual metabolic adaptations that specialize them for growth within heme-rich human erythrocytes. During blood-stage infection,

Unraveling The Role Of Uils, A Urea-Induced Acyl-Homoserine Lactonase That Enhances Serratia Marcescens Fitness, Interbacterial Competition, And Urinary Tract Infection, Marisel R Tuttobene, Brayan S Arango Gil, Gisela Di Venanzio, Javier F Mariscotti, Rodrigo Sieira, Mario F Feldman, María Soledad Ramirez, Eleonora García Véscovi

2020-Current year OA Pubs

UNLABELLED:

IMPORTANCE: This work reveals the acyl-homoserine lactonase

Whole-Blood Model Reveals Granulocytes As Key Sites Of Dengue Virus Propagation, Expanding Understanding Of Disease Pathogenesis, Hansa Praneechit, Somchai Thiemmeca, Dararat Prayongkul, Kessiri Kongmanas, Dumrong Mairiang, Nuntaya Punyadee, Adisak Songjaeng, Nattaya Tangthawornchaikul, Nasikarn Angkasekwinai, Kanokwan Sriruksa, Yupin Suputtamongkol, Wannee Limpitikul, John P Atkinson, Panisadee Avirutnan

2020-Current year OA Pubs

Dengue virus (DENV) infection poses a significant global health threat, yet our understanding of its immunopathogenesis remains incomplete due to limitations of existing models. Here, we establish an

Incidence, Healthcare And Out-Of-Pocket Costs, And Mortality Of Clostridioides Difficile Infection Among Us Adults Aged 18 To 64 Years, Holly Yu, Tamuno Alfred, Jingying Zhou, Jennifer Judy, Margaret A. Olsen

2020-Current year OA Pubs

No abstract provided.

A Trivalent Mucosal Vaccine Encoding Phylogenetically Inferred Ancestral Rbd Sequences Confers Pan-Sarbecovirus Protection In Mice, James Brett Case, Shilpa Sanapala, Suzanne M Scheaffer, Déborah Carolina Carvalho Dos Anjos, Lucas J Adams, Nadia Soudani, Chieh-Yu Liang, Baoling Ying, Adrianus C M Boon, Daved H Fremont, Sean P J Whelan, Michael S Diamond, Et Al.

2020-Current year OA Pubs

The continued emergence of SARS-CoV-2 variants and the threat of future Sarbecovirus zoonoses have spurred the design of vaccines that can induce broad immunity against multiple coronaviruses. Here, we use computational methods to infer ancestral phylogenetic reconstructions of receptor binding domain (RBD) sequences across multiple Sarbecovirus clades and incorporate them into a multivalent adenoviral-vectored vaccine. Mice immunized with this pan-Sarbecovirus vaccine are protected in the upper and lower respiratory tracts against infection by historical and contemporary SARS-CoV-2 variants, SARS-CoV, and pre-emergent SHC014 and Pangolin/GD coronavirus strains. Using genetic and immunological approaches, we demonstrate that vaccine-induced protection unexpectedly is conferred principally …

Type I Interferon Signaling In Dendritic Cells Limits Direct Antigen Presentation And Cd8+ T Cell Responses Against An Arthritogenic Alphavirus, Christopher B Bullock, Leran Wang, Brian C Ware, Ngan Wagoner, Ray A Ohara, Tian-Tian Liu, Pritesh Desai, Bjoern Peters, Kenneth M Murphy, Scott A Handley, Thomas E Morrison, Michael S Diamond

2020-Current year OA Pubs

Ross River virus (RRV) and other alphaviruses cause chronic musculoskeletal syndromes that are associated with viral persistence, which suggests deficits in immune clearance mechanisms, including CD8

Effects Of Dietary Medium-Chain Triglyceride Supplementation On The Serum Metabolome Of Young Adult And Senior Canines, Yuanlong Pan, Miriam Sindelar, Ethan Stancliffe, Leah P Shriver, Rondo P Middleton, Gary J Patti

2020-Current year OA Pubs

In dogs, brain aging may lead to cognitive decline and cognitive dysfunction syndrome (CDS) [...].

Type I Ifn-Mediated Net Release Promotes Mycobacterium Tuberculosis Replication And Is Associated With Granuloma Caseation, Chanchal Sur Chowdhury, Rachel L Kinsella, Michael E Mcnehlan, Sumanta K Naik, Daniel S Lane, Priyanka Talukdar, Asya Smirnov, Neha Dubey, Ananda N Rankin, Samuel R Mckee, Reilly Woodson, Abigail Hii, Sthefany M Chavez, Darren Kreamalmeyer, Wandy Beatty, Joshua T Mattila, Christina L Stallings

2020-Current year OA Pubs

Neutrophils are the most abundant cell type in the airways of tuberculosis patients. Mycobacterium tuberculosis (Mtb) infection induces the release of neutrophil extracellular traps (NETs); however, the molecular regulation and impact of NET release on Mtb pathogenesis are unknown. We find that during Mtb infection in neutrophils, PAD4 citrullinates histones to decondense chromatin that gets released as NETs in a manner that can maintain neutrophil viability and promote Mtb replication. Type I interferon promotes the formation of chromatin-containing vesicles that allow NET release without compromising plasma membrane integrity. Analysis of nonhuman primate granulomas supports a model where neutrophils are exposed …

Review Of Epidemiology, Prevention And Management Of Blood-Borne Viruses Experienced By Aboriginal And Torres Strait Islander Peoples, Katiska Davis, Eliza Lock, Laura Thum, Gemma Crawford, Roanna Lobo, Odette Aung Thein, Shane Kavanagh, Jonathan Hallett

Journal of the Australian Indigenous HealthInfoNet

This review examines the epidemiology, prevention, and management of blood-borne viruses (BBVs) experienced by Aboriginal and Torres Strait Islander peoples in Australia with a focus on hepatitis B, hepatitis C, and HIV. The review highlights the disproportionate burden of BBVs among Aboriginal and Torres Strait Islander peoples in Australia, influenced by historical, social, and cultural factors stemming from colonisation. Key findings include higher prevalence rates of hepatitis B and C compared to non-Indigenous Australians, with some progress in reducing new infections through vaccination and treatment programs. However, significant gaps remain in screening, linkage to care, and treatment uptake. The review …

Reply To Author Regarding The Letter “Postoperative Atrial Fibrillation After Cardiac Surgery”, Yasuhiko Imashuku, Susumu Hiraoka, Motoi Inoue, Takayoshi Mizuno, Misuzu Oyagi, Hirotoshi Kitagawa

Journal of the Saudi Heart Association

No abstract for this article type.

Postoperative Atrial Fibrillation After Cardiac Surgery, Mesut Engin, Abdulkerim Özkan, Abdurrahman Demirel

Journal of the Saudi Heart Association

No abstract for this article type.

Immunization-Related Complex Regional Pain Syndrome: A Systematic Review Of Case Reports, William K Copenhaver, Brandon J Goodwin, Alexa Simonetti, Kunal P. Shah, Nicholas J Averell, David F Lo, Richard T Jermyn

Rowan-Virtua School of Osteopathic Medicine Departmental Research

AIM: Vaccines have been shown to have the highest efficacy in preventing infectious diseases through their ability to induce immunological memory against pathogens. An adverse reaction to a vaccine is an unexpected medical occurrence following immunization. Complex regional pain syndrome (CRPS) is a disease that has undergone much controversy regarding its onset post-vaccination. This systematic review aims to evaluate cases of CRPS post-vaccination to better understand the manifestation of the disease and its potential association with vaccines.

METHODS: A systematic review of case reports was conducted employing the PRISMA 2020 guidelines. Outcomes of interest include type of vaccination, patient age, …

The Role And Therapeutic Possibilities Of Pelp1 In Hepatocellular Carcinoma (Hcc) Cells, Marian Hernandez Fernandez

Honors Program Theses and Research Projects

Hepatocellular carcinoma (HCC) is the most rapidly increasing cause of cancer mortality in the USA and ranks as the fourth leading cause of cancer-related deaths worldwide. Moreover, advanced HCC has a bleak prognosis, with a median survival rate of approximately 10 months. Latinos in South Texas exhibit the greatest incidence of liver cancer nationwide. Proline-, glutamic acid-, and leucine-rich protein 1 (PELP1) is an oncogene associated with the advancement of several cancers; however, its function in hepatocellular carcinoma (HCC) remains unclear. Analysis of publicly accessible cancer databases revealed elevated expression of PELP1 oncogene in HCC relative to the control group. …

Defining Renal Recovery In Patients With Hepatorenal Syndrome-Acute Kidney Injury: Experience From North American Studies, Muhammad A. Mujtaba, Hussien Elsiesy, Sara Faiz, Syed A. Hussain, Ann Kathleen N. Gamilla-Crudo, Aftab Karim, Mohammad I. Khan, Muhammad W. Khattak, Zunaira Zafar, Michael Kueht, Khurram Jamil

Jefferson Health - Northeast Papers (formerly Aria Health Papers)

INTRODUCTION: The degree of improvement in serum creatinine (SCr) has previously been suggested as a sensitive indicator of treatment response in patients with hepatorenal syndrome-acute kidney injury (HRS-AKI), while HRS reversal remains the primary endpoint in clinical trials.

METHODS: A total of ≥ 30% SCr improvement was analyzed as an exploratory prespecified endpoint in the CONFIRM trial. In this post hoc analysis, intent-to-treat population data from three Phase 3 studies (OT-0401, REVERSE, and CONFIRM) conducted in North America in patients with HRS-AKI were pooled to assess the incidence of > 30% improvement in SCr and its association with clinical outcomes.

RESULTS: …

Lipid Discovery Enabled By Sequence Statistics And Machine Learning, Priya M. Christensen, Jonathan Martin, Aparna Uppuluri, Luke R. Joyce, Yahan Wei, Ziqiang Guan, Faruck Morcos, Kelli L. Palmer

School of Podiatric Medicine Publications

Bacterial membranes are complex and dynamic, arising from an array of evolutionary pressures. One enzyme that alters membrane compositions through covalent lipid modification is MprF. We recently identified that Streptococcus agalactiae MprF synthesizes lysyl-phosphatidylglycerol (Lys-PG) from anionic PG, and a novel cationic lipid, lysyl-glucosyldiacylglycerol (Lys-Glc-DAG), from neutral glycolipid Glc-DAG. This unexpected result prompted us to investigate whether Lys-Glc-DAG occurs in other MprF-containing bacteria, and whether other novel MprF products exist. Here, we studied protein sequence features determining MprF substrate specificity. First, pairwise analyses identified several streptococcal MprFs synthesizing LysGlc-DAG. Second, a restricted Boltzmann machine-guided approach led us to discover an …

Coexisting Growing Teratoma Syndrome And Gliomatosis Peritonei Following Ovarian Immature Teratoma: A Case Report And Literature Review, Osman Türkmen, Serra Akar İnan, Serap Akbay, Mohammad İbrahi̇m Hali̇lzade, İnci̇ Hali̇lzade, Özlem Moraloğlu Teki̇n

Turkish Journal of Medical Sciences

Background/aim: Growing teratoma syndrome (GTS) is marked by the reduction in serum tumor markers, despite the growth of a benign mature teratomatous mass after chemotherapy treatment for germ cell tumors. Gliomatosis Peritonei (GP) is often seen with ovarian teratomas, involving the spread of mature glial tissue on the peritoneum. The coexistence of GP with GTS following treatment for ovarian immature teratoma (IMT) is particularly rare with about 20 cases reported thus far.Case: A 25-year-old patient underwent surgical removal of an adnexal mass. On paraffin pathology, she was deemed to have stage III A grade 3 ovarian IMT with parametrial involvement. …

Factors Associated With Morbidity Of Totally Implantable Venous Access Device In Patients With Breast Cancer, Burak İlhan, Berkay Kiliç

Turkish Journal of Medical Sciences

Background/aim: To investigate the possible morbidities associated with the implantation of a totally implantable venous access device (TIVAD) in breast cancer (BC) patients.Materials and methods: Clinical data and developed complications in 546 BC patients with TIVAD between 2017 and 2021 were analyzed retrospectively. Among these patients, 524 (96.0%) patients who underwent TIVAD implantation via the right subclavian vein (SCV) route were examined separately.Results: The mean patient age was 56.1±11.4 years, and the mean patient body mass index was 25.3±6.5. The incidence of early complications was 2.3% (12 cases), and late complications were 2.6% (14 cases). Among these complications, 10 (1.9%) …

Transition Of Patients With Systemic Lupus Erythematosus From Pediatric To Adult-Oriented Rheumatology Care, Seher Şener, Gözde Yardimci, Ezgi̇ Batu, Levent Kiliç, Ümmüşen Kaya Akça, Müşerref Kasap Cüceoğlu, Zeynep Balik, Özge Başaran, Yelda Bi̇lgi̇ner, Şule Apraş Bi̇lgen, Seza Özen

Turkish Journal of Medical Sciences

Background/aim: The transition from pediatric to adult-oriented care for individuals with juvenile-onset systemic lupus erythematosus (SLE) poses significant challenges. This study aims to assess the outcomes of transitioning patients with juvenile-onset SLE from pediatric to adult-oriented care.Materials and Methods: Patients with juvenile-onset SLE were included. They were transferred in face-to-face meetings where at least one pediatric rheumatologist and one adult rheumatologist were present (the transition time: October-December 2020).Results: The median (25th-75th percentiles) age at diagnosis and the time of the first examination at an adult-oriented rheumatology department of 65 SLE patients were 14.3 (10.9-15.1) years and 19.2 (18.5-20.4) years, respectively …

A New Scoring In Differential Diagnosis: Multisystem Inflammatory Syndrome Or Adenovirus Infection?, Mustafa Gençeli̇, Talha Üstüntaş, Özge Akcan, Si̇nan Saylik, Fati̇h Ercan, Sevgi̇ Pekcan, Si̇pi̇l Gençeli̇, Sevgi̇ Durmuş, Mustafa Argun

Turkish Journal of Medical Sciences

Background/aim: Differentiating multisystem inflammatory syndrome in children (MIS-C) from adenovirus infection (AI) can be challenging due to similar clinical and laboratory findings. This study aimed to identify distinguishing characteristics and develop a scoring system to facilitate accurate diagnosis.Materials and methods: A comprehensive review of medical records was undertaken for 108 MIS-C cases and 259 patients with confirmed AI. A comparison of laboratory data and clinical findings was conducted across patient groups through appropriate statistical tests.Results: MIS-C patients were significantly older than AI patients (p<0.001). Diarrhea, rash, abdominal pain, vomiting, non-exudative conjunctivitis, lymphadenopathy tachycardia, bradycardia, hypotension, hypoxia seizures, agitation, headache, and altered consciousness symptoms were more frequently associated with MIS-C (p<0.001), while cough and runny nose were significantly more common in AI (p<0.001). Lymphopenia and thrombocytopenia were more prevalent in MIS-C patients (p<0.001). AI and MIS-C were scored by giving 1 point each to the parameters that created the difference. For AI, ≤60 months, presence of cough, runny nose and absence of diarrhea, rash, abdominal pain, vomiting, non-exudative conjunctivitis, lymphadenopathy, tachycardia, bradycardia, hypotension, hypoxia seizures, agitation, headache, and altered consciousness, lymphopenia, thrombocytopenia and CRP <124.5 mg/L were determined as each parameter plus one point. A total score above 14 could predict AI with a high degree of accuracy sensitivity values stood at around 97.5% and specificity at 92.6%.Conclusion: The proposed inpatient scoring system, when used in conjunction with polymerase chain reaction testing, may improve the early differentiation of AI and MIS-C. This approach could help reduce unnecessary testing and optimize resource allocation. Further research with larger samples should investigate this novel scoring system to establish its reliability and generalizability.

Implementation Of Written Asthma Action Plan Among Asthma Patients In Türkiye: A Multicenter, Cross-Sectional, Descriptive Study, Kurtuluş Aksu, Gürgün Tuğçe Vural Solak, Pinar Mutlu, Levent Cem Mutlu, Görkem Vayişoğlu Şahi̇n, Burcu Yormaz, Ayli̇n Çapraz, Ezgi̇ Erdem Türe, Yavuzalp Solak, Funda Aksu

Turkish Journal of Medical Sciences

Background/aim: In our country, there is no data on whether the clinicians give an asthma action plan to implement to patients followed up with a diagnosis of asthma, and whether patients can manage their treatment according to this plan. The present study aimed to determine the use of asthma action plans in our country and the awareness levels of patients about the plan.Materials and methods: Multicenter, cross-sectional descriptive study was conducted in outpatient immunology and allergy and pulmonology clinics of secondary and tertiary health-care centers. Adults asthmatics filled out a case registration form regarding age, gender, educational status, duration of …

Evaluation Of The Update On Screening For Retinopathy Of Prematurity In A Tertiary Care Center In Türkiye With Retrospective Cohort, Emi̇ne Kaya Güner, Duygu İnci̇ Bozbiyik

Turkish Journal of Medical Sciences

Background/aim: In Turkey, recommendations for screening for retinopathy of prematurity (ROP) have been updated in 2021. Herein, we aimed to present detailed data on the infants included in the screening according to the new criteria and evaluate whether these changes benefit in detecting severe ROP.Materials and Methods: Our hospital's medical records of babies screened for ROP between July 2019 - July 2021 and August 2021 - August 2023 were retrospectively examined. Gestational age (GA), birth weight (BW), gender of the babies, whether there was a multiple pregnancy, ROP examination results, the most advanced ROP level and time, and ROP treatment …

Rare Stat3 Haplotypes Cause A Predisposition To Develop Congenital Anomalies Of The Kidney And Urinary Tract Disorder, Mert Polat, Feri̇de Şahi̇n, Esra Baskin, Uğur Toprak, Kaan Gülleroğlu, Mehmet Haberal, Yunus Terzi̇

Turkish Journal of Medical Sciences

Background/aimCongenital anomalies of the kidney and urinary tract (CAKUT) are characterized by renal developmental disorders in the embryonic period. STAT3 is a member of the STAT protein family. The members of this protein family play roles in various cellular mechanisms, such as the early stages of embryonic development, kidney development, and renal diseases. This study aims to determine the frequency of STAT3 rs1053004, rs744166, rs3816769, and rs4796793 polymorphisms in individuals with CAKUT disease.Materials and methodsTwo of the four polymorphisms, rs744166 (c.-1-13666T>C, NM_001369512.1) and rs4796793 ( c.-1915C>G, NM_001369512.1), were analyzed by a polymerase chain reaction and restriction fragment length …

Evaluation Of The Efficacy Of Transfer Energy Capacitive And Resistive Therapy In Patients With Knee Osteoarthritis, Özge Tezen, Emi̇ne Esra Bi̇li̇r, Öznur Uzun, Duygu Yaniktaş, Başak Şentürk, Evren Yaşar

Turkish Journal of Medical Sciences

Background/aim: The aim of present study was to investigate the treatment efficacy of transfer energy capacitive and resistive (TECAR) therapy, a modern application that has been increasingly used in recent years, compared to conventional physical therapy (CPT) applications in the treatment of knee osteoarthritis, according to the evaluation of clinical findings of patients.Materials and methods: A total of 54 patients, aged between 40 and 75 years, were randomly divided into two groups. Both groups received CPT. Group 2 received TECAR therapy in addition to CPT, applied three times a week for two weeks, for a total of 6 sessions. All …

Achillea Millefolium Ameliorates Doxorubicin-Induced Renal Injury Via Inhibition Of Oxidative Stress And Inflammation In Rats, Mohammed Shaiea, Yi̇mi̇ng Dong, Saleh Alomisy, Hassan Al-Mahbashi, Guozhong Zhang, Chuan Wang

Turkish Journal of Medical Sciences

Background/aim: Doxorubicin (Dox) is a potent anticancer medication. Nevertheless, due to nephrotoxicity, its clinical application is restricted. Achillea millefolium (AM) is a traditional medicine used against several disturbances, including kidney disorders. Therefore, this work aims to investigate the preventative properties of AM extract (AME) and their mechanisms against nephrotoxicity caused by Dox in rats. Materials and methods: The rats were assigned randomly to six groups, including a control group, Dox group (5 mg/kg/week via i.p. for 4 weeks), two groups, AME (100 or 200 mg/kg, orally for 28 days), and the last two groups, Dox+ AME (100 or 200 mg/kg, …

The Difference Between Clinical Significance And Statistical Significance: An Important Distinction For Clinical Research, Sadi̇ Elasan

Turkish Journal of Medical Sciences

No abstract provided.