Medicine and Health Sciences Commons^™

Benchmarking Lung Cancer Screening Programmes With Adaptive Screening Frequency Against The Optimal Screening Schedules Derived From The Engage Framework: A Comparative Microsimulation Study, Mehdi Hemmati, Sayaka Ishizawa, Rafael Meza, Edwin Ostrin, Samir M Hanash, Mara Antonoff, Andrew J Schaefer, Martin C Tammemägi, Iakovos Toumazis

Faculty, Staff and Student Publications

Background: Lung cancer screening recommendations employ annual frequency for eligible individuals, despite evidence that it may not be universally optimal. The impact of imposing a structure on the screening frequency remains unknown. The ENGAGE framework, a validated framework that offers fully dynamic, analytically optimal, personalised lung cancer screening recommendations, could be used to assess the impact of screening structure on the effectiveness and efficiency of lung cancer screening.

Methods: In this comparative microsimulation study, we benchmarked alternative clinically relevant structured lung cancer screening programmes employing a fixed (annual or biennial) or adaptive (start with annual/biennial screening and then switch to …

Accelerated Tumor Progression After Covid-19 Infection In Patients With Glioblastoma: A Retrospective Case-Control Study, Timothy A Gregory, Stephanie R Knight, Ashley E Aaroe, Kaitlin N Highsmith, Zachary C Janatpour, Barbara J O'Brien, Nazanin K Majd, Monica E Loghin, Chirag B Patel, Shiao-Pei Weathers, Vinay K Puduvalli, Carlos Kamiya-Matsuoka

Faculty, Staff and Student Publications

Background: We observed rapid tumor progression following COVID-19 infection among patients with glioblastoma and sought to systematically characterize their disease course in a retrospective case-control study.

Methods: Using an institutional database, we retrospectively identified a series of COVID-19-positive glioblastoma cases and matched them by age and sex 1:2 to glioblastoma controls who had a negative COVID-19 test during their disease course. Demographic and clinical data were analyzed. Hyperprogression was defined using modified response evaluation criteria in solid tumors criteria. Time to progression and overall survival were estimated using the Kaplan-Meier method.

Results: Thirty-two glioblastoma cases with positive COVID-19 testing were …

Variability In Performance Of Genetic-Enhanced Dxa-Bmd Prediction Models Across Diverse Ethnic And Geographic Populations: A Risk Prediction Study, Yong Liu, Xiang-He Meng, Chong Wu, Kuan-Jui Su, Anqi Liu, Qing Tian, Lan-Juan Zhao, Chuan Qiu, Zhe Luo, Martha I Gonzalez-Ramirez, Hui Shen, Hong-Mei Xiao, Hong-Wen Deng

Faculty, Staff and Student Publications

BACKGROUND: Osteoporosis is a major global health issue, weakening bones and increasing fracture risk. Dual-energy X-ray absorptiometry (DXA) is the standard for measuring bone mineral density (BMD) and diagnosing osteoporosis, but its costliness and complexity impede widespread screening adoption. Predictive modeling using genetic and clinical data offers a cost-effective alternative for assessing osteoporosis and fracture risk. This study aims to develop BMD prediction models using data from the UK Biobank (UKBB) and test their performance across different ethnic and geographical populations.

METHODS AND FINDINGS: We developed BMD prediction models for the femoral neck (FNK) and lumbar spine (SPN) using both …

Antitumor Activity Of A Novel Lair1 Antagonist In Combination With Anti-Pd1 To Treat Collagen-Rich Solid Tumors, Bertha L Rodriguez, Jiawei Huang, Laura Gibson, Jared J Fradette, Hung-I H Chen, Kikuye Koyano, Czrina Cortez, Betty Li, Carmence Ho, Amir M Ashique, Vicky Y Lin, Suzanne Crawley, Julie M Roda, Peirong Chen, Bin Fan, Jeong Kim, James Sissons, Jonathan Sitrin, Daniel D Kaplan, Don L Gibbons, Lee B Rivera

Faculty, Staff and Student Publications

We recently reported that resistance to PD-1 blockade in a refractory lung cancer-derived model involved increased collagen deposition and the collagen-binding inhibitory receptor leukocyte-associated immunoglobulin-like receptor 1 (LAIR1). Thus, we hypothesized that LAIR1 and collagen cooperated to suppress therapeutic response. In this study, we report that LAIR1 is associated with tumor stroma and is highly expressed by intratumoral myeloid cells in both human tumors and mouse models of cancer. Stroma-associated myeloid cells exhibit a suppressive phenotype and correlate with LAIR1 expression in human cancer. NGM438, a novel humanized LAIR1 antagonist mAb, elicits myeloid inflammation and allogeneic T-cell responses by binding …

The T2-Flair Mismatch Sign In Oncologic Neuroradiology: History, Current Use, Emerging Data, And Future Directions, Samir A Dagher, Riley Hideo Lochner, Burak Berksu Ozkara, Donald F Schomer, Max Wintermark, Gregory N Fuller, F Eymen Ucisik

Faculty, Staff and Student Publications

The T2-Fluid-Attenuated Inversion Recovery (T2-FLAIR) mismatch sign is a radiogenomic marker that is easily discernible on preoperative conventional MR imaging. Application of strict criteria (adult population, cerebral hemisphere location, and classic imaging morphology) permits the noninvasive preoperative diagnosis of isocitrate dehydrogenase (IDH)-mutant 1p/19q-non-codeleted diffuse astrocytoma with near-perfect specificity, albeit with variably low sensitivity. This leads to improved preoperative planning and patient counseling. More recent research has shown that the application of less strict criteria compromises the near-perfect specificity of the sign but remains adequate for ruling out IDH-wildtype (glioblastoma) phenotype, which bears a far grimmer prognosis compared to IDH-mutant diffuse …

The Effect Of Intermediate Doses Of Roundup® On The Larval Development, Survival, Oviposition And Fitness Of Culex Quinquefasciatus, Abdoulaye Aziz Zerbo

Electronic Theses, Projects, and Dissertations

The southern house mosquito, Culex quinquefasciatus, is a vector to many pathogens in Southern California, including West Nile Virus and St. Louis Encephalitis Virus. Immature stages of mosquitoes may be exposed to Roundup^®, a frequently used herbicide worldwide, due to surface runoffs or overspraying and subsequent drifting. Previous studies have shown some negative impacts of sublethal doses of Roundup^® during the developmental stage of Culex quinquefasciatus, such as physiologic changes and prolonged larval stage or the high mortality of larvae due to exposure to the high doses of glyphosate. This study investigated the effect of …

Emotional Eating In Adolescents With Obesity: Case Series, Paula Dayan

Electronic Theses, Projects, and Dissertations

Childhood obesity remains a significant public health concern, with substantial implications for physical and mental well-being. This thesis aims to explore the intricate relationship between emotional eating and obesity among adolescents, with a focus on identifying emotional triggers and assessing their psychological impact. Utilizing a cross-sectional study design at a university in southern California, data were collected from two adolescents aged 13-18 years. Through surveys and body composition measurements, participants' emotional barriers to weight loss and readiness for change were assessed. The findings underscore the presence of varying degrees of emotional hurdles among adolescents with obesity, including depression, frustration, and …

Advancing Telehealth Through Artificial Intelligence: Incorporating Emotional Intelligence And Addressing Cybersecurity Challenges, Mahima Rajendra Pulgaonkar

Electronic Theses, Projects, and Dissertations

This culminating experience project explores the integration of Emotional Artificial Intelligence (Emotional AI) into telehealth systems, addressing the dual challenges of enhancing patient care and mitigating cybersecurity risks. The research questions are: (Q1) How can Emotionally Intelligent AI improve telehealth systems' ability to recognize and respond to mental health symptoms? and (Q2) What are the specific cybersecurity challenges associated with AI in telehealth and how can they be mitigated? The findings for each question are: Q1: Emotionally Intelligent AI can significantly enhance telehealth by providing personalized, empathetic interactions that improve patient engagement, adherence to treatment plans, and early detection of …

Changes In Blood Lactate And High Intensity Exercise Endurance During A Strength - Endurance Accumulation Training Using Accentuated Eccentric Loading, Nicholas Goode

Electronic Theses and Dissertations

The purpose of this study was to investigate the effects of accentuated eccentric load (AEL) resistance training and changes in work capacity, high-intensity exercise endurance (HIEE) and lactate metabolism. Seventeen recreationally trained subjects (11 males and 6 females) (mean ± SD: age = 23.2 ± 4.2 yrs, BM = 81.3 ± 22.2 kg, height = 172.1 ± 10 cm, male relative back squat (BS) [MD1] strength (1RM*BM^-1) = 1.64 ± 0.32 kg*kg^-1, female relative BS strength = 1.39 ± 0.32 kg*kg^-1) participated in the study. Subjects completed a week of familiarization to participate in …

The Characterization Of Cacna1a-Related Hemiplegic Migraine, Donna P. Schaare

All Dissertations

CACNA1A-related Hemiplegic Migraine (HM) is a rare neurodevelopmental disorder characterized by paroxysmal episodes of hemiparesis/hemiplegia with or without headache. The presentation of CACNA1A-related HM can range from mild HM events in neurotypical individuals to life-threatening prolonged periods of hemiplegia with cerebral edema in individuals with baseline neurodevelopmental features. CACNA1A-related HM has been studied extensively in its familial form, Familial Hemiplegic Migraine type 1 (FHM1), but the often more severe disorder attributed to de novo variants, Sporadic Hemiplegic Migraine type 1 (SHM1), has had limited description. Genetic resources and the 3^rd edition of the International Classification of …

Assessment Of American Tannin-Free Grain Sorghum As Feedstuff For Poultry: Nutrient Composition, Amino Acid Digestibility And Bird Performance, Santiago Sasia

All Dissertations

Given the rising cost of poultry diets, alternative ingredients like sorghum are crucial for maximizing returns without compromising product quality. Sorghum's drought tolerance and adaptability, along with its nutritional profile, make it a viable corn substitute. This dissertation examines the nutrient composition, amino acid digestibility, and performance of poultry fed with American tannin-free grain sorghum. Chapter II evaluates the impact of sorghum-based diets, with or without phytase superdosing, on broiler performance, including body weight, weight gain, feed intake, and feed conversion ratio. Results indicate that sorghum can replace corn without adverse effects on broiler performance. Chapter III explores the partial …

Effect Of Insufficient Sleep On Activity Limitation: Results From The Brfss 2022 Survey, Jonathan Meyer

Capstone Experience: Master of Public Health

Objective: To determine whether insufficient sleep (less than 7 hours per night) is associated with activity limitation (14 days or more of poor mental or physical health interfering with everyday activities) in Behavioral Risk Factor Surveillance System (BRFSS) survey data from 2022. Methods: BRFSS is a nationally representative cross-sectional survey of non-incarcerated US adults. The exposure of interest was insufficient sleep, and the outcome of interest was activity limitation. Other demographic variables used in a final weighted adjusted analysis include age >65 years, race/ethnicity, gender, marital status, income, and total physical inactivity. Results: The weighted prevalence of insufficient sleep for …

Ensuring Safe Mri Examinations And Earlier Detection Of Recurrent Cancer: A Scoping Review To Identify Breast Tissue Expanders That Are Safe For High-Risk Breast Cancer Survivors, Kristin E. Westmore

Capstone Experience: Master of Public Health

Purpose

This capstone project aims to conduct a scoping review to identify breast tissue expanders that are safe for high-risk breast cancer survivors, ensuring safe magnetic resonance (MR) examinations. The goal is safe MR examinations for early detection of recurrent cancer, post-operative evaluation, monitoring, and reducing preventable morbidity and mortality.

Background

The MR safety of manufacturers' tissue expanders is defined according to the United States Food and Drug Administration (FDA) guidelines and regulations as MR Conditional or MR Unsafe. Before 2023, there was a safety concern about using tissue expanders containing a magnetic port during the first stage of breast …

Exploration Of Canine T. Cruzi Seroprevalence As A Trigger For Enhanced Human Chagas Surveillance, Brittany N. Hocking

Capstone Experience: Master of Public Health

Background: Chagas disease, caused by the parasite Trypanosoma cruzi, is endemic in many Latin American countries and now the southern United States. An increasing number of Chagas cases in the U.S. have occurred because of autochthonous transmission and enzootic cycles involving infected wildlife and domestic animals, like canines.

Objective: This study aimed to explore canine seroprevalence as a trigger for enhanced human Chagas surveillance by describing detected U.S. T. cruzi from human and canine testing data, creating maps to explore geographic areas with potential high yield for T. cruzi surveillance via animal testing, and developing a SWOT analysis for …

Reducing Greenhouse Gases Through Food Waste Reduction: A Literature Review Of Programs And Behavior Change, Schafer Flowerday

Capstone Experience: Master of Public Health

Anthropogenic greenhouse gas (GHG) emissions significantly contribute to climate change. Methane is a potent GHG emitted in landfills as organic material breaks down. Food waste is the single most common item disposed of in Lincoln’s Bluff Road Landfill (LTU, 2022). As such, food waste disposal in the landfill is a preventable issue that could dramatically reduce GHG emissions in Lincoln. This project seeks to determine what barriers and motivations exist for reducing food waste at a consumer level. A literature review was conducted to find what behavior change campaigns and interventions have taken place nationwide to encourage residential food waste …

A Process Evaluation Plan For The Nebraska Fetal Infant Mortality Review (Fimr) Program, Mamello Makhele

Capstone Experience: Master of Public Health

The United States (U.S.) has made substantial progress in reducing fetal and infant mortality, but high rates of infant mortality persist, particularly within minority populations. In Douglas County, Nebraska, racial disparities in infant mortality rates remain a significant issue. In 2019, the infant mortality rate among African American mothers was 14.2 infant deaths per 1,000 live births, compared to 5.7 infant deaths per 1,000 live births among Caucasian mothers.

To reduce fetal and infant mortality in the U.S., the Centers for Disease Control and Prevention along with the Human Resources and Services Administration, fund the Fetal and Infant Mortality Review …

Current Status Of Colorectal Cancer Screening Among Adults With And Without Cognitive Disabilities In The United States, 2022, Elma Vasconcelos

Capstone Experience: Master of Public Health

Objective: Evaluate the prevalence of non-compliance with colorectal cancer screening guidelines among US adults aged 45-75, comparing individuals with cognitive disabilities to those without.

Methods: This study utilized data from the 2022 Behavioral Risk Factor Surveillance System survey, which uses weighted and complex survey sampling methodologies. Participants under 45 were excluded, resulting in a study sample of 220,879. Univariate, bivariate, and multivariable logistic regression analyses were conducted to assess the prevalence odds ratio of colorectal cancer screening among individuals with and without cognitive disabilities.

Results: Those with cognitive disabilities had 1.07 (95% CI: 0.99-1.15) times the odds of not adhering …

Association Between Lifestyle Behaviors And Type 2 Diabetes Among African Immigrants In The United States, Momo Joemah Johnson

Walden Dissertations and Doctoral Studies

Recent evidence demonstrates that African immigrants are healthier than African immigrants born in the United States. After individuals have stayed in the United States for a duration of 4–5 years, the health gap starts to narrow significantly as health conditions worsen. Acculturation and body mass likely play a role; physical inactivity and psychological distress may arbitrate the association. T2DM is an expanding global health problem that is closely linked to the epidemic of obesity. Individuals with T2DM are at risk of other complications that include retinopathy, nephropathy, neuropathy, and microvascular complications. The purpose of the study was to assess the …

Acute Effects Of Multi-Joint Eccentric Exercise On Lower Extremity Muscle Activation Measured During Land And Water Walking, Brayden Worley

All Graduate Reports and Creative Projects, Fall 2023 to Present

Although prior literature has established the preliminary clinical benefits of aquatic exercise across various clinical populations, there is a need to explore the potential for including aquatic-based movement as a key component of a multi-modal approach toward improving mobility and reducing fall risk. Eccentric exercise may complement aquatic exercise given that movements performed in water immersion tend to be low impact. Eccentric exercise may also improve the passive stiffness of lower extremity extensors, which gives an additional rationale for the potential of eccentric exercise to reduce fall risk when combined with aquatic exercise. There may also be an acute response …

Sustainable Waste-To-Bioproducts Engineering Center Laboratory Safety Project, Claudine Mock

All Graduate Reports and Creative Projects, Fall 2023 to Present

Laboratory accidents are common in teaching and research labs; these accidents can be injurious or even fatal. The consequences of each type of laboratory accident are different based on the activities performed and the hazardous materials used in each facility. However, the most common issue related to laboratory accidents is the lack of proper safety measures (e.g., poor handling of hazardous materials, not reporting incidents immediately, etc.). This project aimed to establish and strengthen best practices and procedures to ensure laboratory safety at the Utah State University Sustainable Waste-to-Bioproducts Engineering Center. To achieve this goal, different practices and measures were …

Acute Changes In Inflammatory Biomarkers Expression Following Cosmetic Surgery With Use Of Compression Garment, Michael James Sanchez

Open Access Theses & Dissertations

BACKGROUND: Inflammation is an acute phase response to physiological conditions such as infection, tissue injury, and tissue stress and malfunction (Medzhitov, 2008). Inflammation caused by surgical trauma (tissue injury) elicits a myriad of responses by the patient that is experienced far past the operation. It is estimated that American individuals will undergo nine surgeries throughout an 85 year lifespan (Lee & Gawande, 2008). Focus on surgical recovery modalities has grown over the past few decades. The use of compression garments (CG+) following surgery has been shown to be successful in preventing deep vein thrombosis, pulmonary embolisms, as well as aiding …

Experimental And Theoretical Investigation Of The Coordination Of 8-Hydroxquinoline Inhibitors To Biomimetic Zinc Complexes And Histone Deacetylase 8 (Hdac8), Anthony M. Baudino, Harris F. Ciaccio, Michael J. Turski, Xavier A. Akins, Phoebus Sun Cao, Elisa Morales, Roger D. Sommer, Adam R. Johnson, Donald J. Wink, Kyle A. Grice, Kari Stone

Chemistry Department Faculty Articles

Zinc is integral to diverse biological functions, acting catalytically, structurally, and supportively in essential enzyme cycles, despite its limited amounts in the body. Targeting zinc enzymes with potent drugs, such as Vorinostat, demonstrates the therapeutic efficacy of zinc-binding ligands, notably in cutaneous T-cell lymphoma treatments. Our study merges experimental and theoretical approaches to analyze the coordination of 8-hydroxylquinoline (8HQ) inhibitors with biomimetic zinc complexes and human histone deacetylase 8 (HDAC8), a monozinc hydrolase enzyme. Assessing 10 8HQ derivatives for structural and electronic characteristics against these models, we observe minimal inhibition efficacy, corroborated through protein–ligand docking analyses, highlighting the complexities of …

Hold Tightly To The Human Touch, Michelle C. Dziurgot Dds

The Journal of the Michigan Dental Association

In this editorial, Dr. Dziurgot reflects on the diminishing human interaction in various services, from ordering food to medical appointments. The editorial emphasizes the importance of maintaining personal communication in dentistry, arguing that patient care should remain personalized and compassionate. The author reminisces about the personalized service of the past, stressing the need for dentists to engage directly with patients, understand their unique needs, and provide a welcoming environment. The piece calls for a return to human touch in professional practices, despite the convenience of modern technology.

Mda At Your Service: My License Expired, And I’M Overwhelmed, Kristin Johnson Dds

The Journal of the Michigan Dental Association

The Michigan Public Health Code allows a 60-day grace period for license renewal with late fees and CE requirements. For health insurance options, MDA Insurance provides assistance and quotes. Attend the MDA Health Insurance Seminar on Oct. 25 for more insights. Engage in organized dentistry via local society meetings, the MDA Leadership Forum, and the LEAD Program. MDA Insurance offers Medicare support, including educational events on Sept. 13 and 27. For more details, contact relevant MDA representatives.

The New Professional: Mastering Those Awkward Moments With Patients, Amrita Patel Dds

The Journal of the Michigan Dental Association

Navigating awkward moments in a dental office is essential for positive patient experiences. Establish rapport with patients, use active listening, and avoid jargon. Prepare for common scenarios, communicate clearly, and address fears. Stay calm with difficult questions and provide honest answers. Train staff through role-play and feedback, and cultivate a positive, empathetic environment. Regularly solicit patient feedback to improve. These strategies ensure patients feel valued and supported.

Mda Insurance: At Last – A Guaranteed Issue Life Insurance Policy That Can Help Pay For Catastrophic Care, Craig Start

The Journal of the Michigan Dental Association

Families face tough caregiving decisions due to high custodial care costs, often resulting in financial and emotional strain. MDA Insurance offers an affordable whole life insurance policy with a catastrophic loss rider, providing $2,000 monthly for up to 12 months for those unable to perform daily living activities. This policy, issued by Boston Mutual Life Insurance, is available on a guaranteed-issue basis and accumulates cash value. Apply by Aug. 30 for an Oct. 1 effective date. Contact MDA Insurance for more information.

J Mich Dent Assoc August 2024

The Journal of the Michigan Dental Association

Every month, The Journal of the Michigan Dental Association provides news, information, and features about Michigan dentistry to our state's oral health community and the MDA's 6,200+ members. It stands as the primary publication reaching Michigan dentists.

In the August 2024 issue, the Journal focuses on the 2024 Mission of Mercy event held in Flint Original content includes:

• A cover story on the MOM

• A feature article on Locum Tenens Dentists

• A New Professional Column

• News You Need, an editorial, and regular department articles covering MDA Foundation activities, MDA Services, Dentistry and the Law, and Staff Matters.

Additional feature article …

Mda Foundation Mission Of Mercy: Transforming Lives, Relieving Pain, Anne Berquist

The Journal of the Michigan Dental Association

The MDA Foundation's Mission of Mercy (MOM) dental clinic in Flint provided free dental care to 659 patients over June 14-15, delivering 6,678 procedures valued at $1,156,285. The 120-chair clinic, set up by volunteers, saw patients from 35 Michigan counties and neighboring states. Patients, many of whom queued overnight, received an average of ten procedures each. Volunteers, including retired dentists, performed a wide range of services, from cleanings to complex surgeries. Translators were available to assist non-English speakers, and patients were informed about ongoing free or reduced-cost care options. The event, supported by local donations and community services, will continue …

Integrating Machine Learning And Simulation For Resource Planning Of Hospital Systems Based On Predicted Length Of Stay, S M Atikur Rahman

Open Access Theses & Dissertations

Recently Hospital Systems faced a high invasion of patients generated by several events such as health crisis related epidemic (COVID, FLU) or seasonal flows. Hence, managing hospital bed availability and efficiency with proper care is obligatory for addressing the challenges associated with the overburden of patients. However, the Length of stay (LOS) is often increased due to the high patient influx and overcrowding problem occurs within the Hospital. It resolves these issues, it is essential for hospital authority to predict the Patients LOS which is the crucial indicator for the use of medical resources (allocation, utilization of providers and resource) …

Staff Matters: Assessing Health Benefits For Lgbtq+ Employees, Jodi Schafer Sphr, Shrm-Scp

The Journal of the Michigan Dental Association

To support LGBTQ+ employees, understand your health benefits by asking key questions about domestic partner coverage, mental health benefits, transgender healthcare, IVF, and surrogacy coverage, and identifying LGBTQ+-friendly providers. Regularly check in with staff to ensure benefits meet their needs and consider making changes if necessary. Proactively share benefit information throughout the year to enhance employee recruitment, retention, and engagement.