Medicine and Health Sciences Commons^™

Physical Activity Modifies The Risk Of Incident Cardiac Conduction Disorders Upon Inflammation: A Population-Based Cohort Study, Haiyan Zhao, Man Li, Dan Wu, Shuohua Chen, Chenrui Zhu, Yulong Lan, Hongmin Liu, Yuntao Wu, Shouling Wu

Research outputs 2022 to 2026

BACKGROUND: Emerging evidence suggests a central role for inflammation in cardiac conduction disorder (CCD). It is unknown whether habitual physical activity could modulate the inflammation-associated risks of incident CCD in the general population. METHODS AND RESULTS: This population-based cohort was derived from the China Kailuan study, including a total of 97 192 participants without prior CCD. The end points included incident CCD and its subcategories (atrioventricular block and bundlebranch block). Systemic inflammation was indicated by the monocyte-to-lymphocyte ratio (MLR). Over a median 10.91-year follow-up, 3747 cases of CCD occurred, with 1062 cases of atrioventricular block and 2697 cases of bundle-branch …

Effect Of The Implementation Of A Multiple-Behavior Self-Monitoring Intervention On Dietary Intake In Type 2 Diabetes: Secondary Data Analysis, Jisook Ko, Jing Wang, Ngozi Mbue, Susan Schembre, Stanley Cron

Faculty, Staff and Student Publications

Background: An electronic diary embedded in a mobile device to monitor lifestyle can be as effective as traditional methods. However, the efficacy of self-monitoring multiple behaviors for dietary intake has not been well studied in people with diabetes.

Objective: This study aimed to compare the effect of using technology-assisted self-monitoring versus paper diaries on changes in dietary intake.

Methods: This is a secondary analysis of data collected from 39 people with type 2 diabetes as part of a 3-month pilot clinical trial. Changes in energy intake and the contribution of total fat intake and total carbohydrate intake to total calories …

Association Of Social Determinants, Lifestyle, And Metabolic Factors With Mortality In Chinese Adults: A Nationwide 10-Year Prospective Cohort Study, Jieli Lu, Mian Li, Jiang He, Yu Xu, Ruizhi Zheng, Jie Zheng, Guijun Qin, Yingfen Qin, Yuhong Chen, Xulei Tang, Zhen Ye, Min Xu, Tiange Wang, Lixin Shi, Qing Su, Xuefeng Yu, Li Yan, Zhiyun Zhao, Qin Wan, Gang Chen, Zhengnan Gao, Guixia Wang, Feixia Shen, Xuejiang Gu, Zuojie Luo, Li Chen, Xinguo Hou, Yanan Huo, Qiang Li, Hong Qiao, Yinfei Zhang, Tianshu Zeng, Chunyan Hu, Qiuyu Cao, Xiaojing Jia, Chao Liu, Youmin Wang, Shengli Wu, Tao Yang, Huacong Deng, Hongyan Qi, Xueyan Wu, Di Zhang, Meng Dai, Donghui Li, Shenghan Lai, Lulu Chen, Jiajun Zhao, Yiming Mu, Weiguo Hu, Guang Ning, Ruying Hu, Yufang Bi, Weiqing Wang, 4c Study Group

Faculty, Staff and Student Publications

Nationwide estimates of the impact of common modifiable risk factors on mortality remain crucial. We aim to assess the influence of social determinants, lifestyle, and metabolic factors on mortality in 174,004 adults aged ≥40 years from the China Cardiometabolic Disease and Cancer Cohort (4C) Study. We reveal that 17 modifiable factors are independently associated with mortality, accounting for 64.8% of all-cause mortality, 77.4% of cardiovascular mortality, and 44.8% of cancer mortality. Low education emerges as the leading factor for both all-cause and cancer mortality, while hypertension is predominant for cardiovascular mortality. Moreover, low gross domestic product per capita and high …

Design Of Novel Inhibitors For Ischemia/Reperfusion Injury Targeting Ferroptosis, Xuyang Wang, Qiming Deng, Jingchen Hou, Kalyan Kumar Pasunooti, Kevin C. Bermea, Kai Li, Genaro Antonio Ramirez-Correa

School of Medicine Publications

No abstract provided.

Mice Lacking Astn2 Have Asd-Like Behaviors And Altered Cerebellar Circuit Properties, Michalina Hanzel, Kayla Fernando, Susan E Maloney, Zachi Horn, Shiaoching Gong, Kärt Mätlik, Jiajia Zhao, H Amalia Pasolli, Søren Heissel, Joseph D Dougherty, Court Hull, Mary E Hatten

2020-Current year OA Pubs

Astrotactin 2 (ASTN2) is a transmembrane neuronal protein highly expressed in the cerebellum that functions in receptor trafficking and modulates cerebellar Purkinje cell (PC) synaptic activity. Individuals with

Structural Basis For Substrate Binding And Selection By Human Mitochondrial Rna Polymerase, Karl Herbine, Ashok Nayak, Dmitry Temiakov

Department of Biochemistry and Molecular Biology Faculty Papers

The mechanism by which RNAP selects cognate substrates and discriminates between deoxy and ribonucleotides is of fundamental importance to the fidelity of transcription. Here, we present cryo-EM structures of human mitochondrial transcription elongation complexes that reveal substrate ATP bound in Entry and Insertion Sites. In the Entry Site, the substrate binds along the O helix of the fingers domain of mtRNAP but does not interact with the templating DNA base. Interactions between RNAP and the triphosphate moiety of the NTP in the Entry Site ensure discrimination against nucleosides and their diphosphate and monophosphate derivatives but not against non-cognate rNTPs and …

Impact Of Cyp1a2 Genotypes On The Ergogenic Effects And Subjective Mood States Of Caffeine Ingestion In Resistance-Trained Women, Jessica M Prather, Christine M Florez, Amie Vargas, Bella Soto, Audrey Ross, Abby Harrison, Ariane H Secrest, Darryn S Willoughby, Sydney Kutter, Lem W Taylor

Faculty, Staff and Students Publications

Caffeine’s metabolism is determined by CYP1A2 genotypes: AC/CC (SLOW) and AA (FAST). This trial evaluated CYP1A2 genotypes’ impact on exercise and cognitive effects in 36 resistance-trained females assessed under placebo (PL) and caffeine (6 mg/kg bw anhydrous caffeine-CAF) conditions, before ingestion and throughout the session. 23andMe® (San Francisco, CA, USA) determined genotypes using saliva. Data were analyzed using two-way RMANOVA and paired-samples t-tests (p < 0.05). A significant main effect for genotype existed for leg press repetitions to failure (RTF) for CAF (p = 0.038), with the FAST group performing more repetitions than the SLOW (p = 0.027). There was a significant condition x genotype interaction for the subjective outcome index score (p = …

Junctophilin-2 Regulates Mitochondrial Metabolism, Sasha Z Prisco, Lynn M Hartweck, Felipe Kazmirczak, Jenna B Mendelson, Stephanie L Deng, Madelyn Blake, Satadru K Lahiri, Xander H T Wehrens, Kurt W Prins

Faculty, Staff and Students Publications

No abstract provided.

Epcam-Targeted Betulinic Acid Analogue Nanotherapy Improves Therapeutic Efficacy And Induces Anti-Tumorigenic Immune Response In Colorectal Cancer Tumor Microenvironment, Debasmita Dutta, Ashique Al Hoque, Brahamacharry Paul, Jun Hyoung Park, Chinmay Chowdhury, Mohiuddin Quadir, Soumyabrata Banerjee, Arghadip Choudhury, Soumik Laha, Nayim Sepay, Priyanka Boro, Benny Abraham Kaipparettu, Biswajit Mukherjee

Faculty, Staff and Students Publications

Background: Betulinic acid (BA) has been well investigated for its antiproliferative and mitochondrial pathway-mediated apoptosis-inducing effects on various cancers. However, its poor solubility and off-target activity have limited its utility in clinical trials. Additionally, the immune modulatory role of betulinic acid analogue in the tumor microenvironment (TME) is largely unknown. Here, we designed a potential nanotherapy for colorectal cancer (CRC) with a lead betulinic acid analogue, named as 2c, carrying a 1,2,3-triazole-moiety attached to BA through a linker, found more effective than BA for inhibiting CRC cell lines, and was chosen here for this investigation. Epithelial cell adhesion molecule (EpCAM) …

The Complex Molecular Epileptogenesis Landscape Of Glioblastoma, Victoria Soeung, Ralph B Puchalski, Jeffrey L Noebels

Faculty, Staff and Students Publications

The cortical microenvironment surrounding malignant glioblastoma is a source of depolarizing crosstalk favoring hyperexcitability, tumor expansion, and immune evasion. Neosynaptogenesis, excess glutamate, and altered intrinsic membrane currents contribute to excitability dyshomeostasis, yet only half of the cases develop seizures, suggesting that tumor and host genomics, along with location, rather than mass effect, play a critical role. We analyzed the spatial contours and expression of 358 clinically validated human epilepsy genes in the human glioblastoma transcriptome compared to non-tumor adult and developing cortex datasets. Nearly half, including dosage-sensitive genes whose expression levels are securely linked to monogenic epilepsy, are strikingly enriched …

Comprehensive Technical Analysis Of A Kickboxing Fight In K1 Format Based On Observation, Marta Niewczas, Wojciech Wąsacz, Wiesław Chwała, Tomasz Pałka, Ewa Sobiło-Rydzik, Tadeusz Ambroży, Kristína Němá, Łukasz Rydzik

Baltic Journal of Health and Physical Activity

Introduction: Observation and specialized analysis of confrontations in combat sports are fundamental for introducing corrections in training programs and for modifying the individual technical-tactical profiles of athletes in these types of activities. These actions comprehensively assess the progress of sports activities, ultimately inspiring and guiding the direction of training in sports clubs. The aim of this study was to analyze and assess the level of the offensive structure of Kickboxing sport fights in the K1 format, in terms of global simulated sparring, in selected thematic sets. Materials and Methods: The research material consisted of a multimedia recording of 10 simulated …

Interprofessional Collaboration As A Feminist Pedagogy: A Call For The Unsettling Of Care In Health Professions Education, Ivana Guarrasi, Rhonda Cornell, Sally Clemenson

Feminist Pedagogy

No abstract provided.

The Psychosocial Effect Of Video Games In A Hand Therapy Setting, Frank Arena, Rebecca King

Summer 2024 OTD Capstone Symposium

A project that analyzes the psychosocial effects of video games as an alternative to hand therapy interventions. This project addresses the barriers of financial investment, and space requirements. This project shows the effectiveness of video games as a short-term intervention method.

Adaptive Sports In Schools For Students With Disabilities From An Occupational Therapy Perspective, Tamara Harvey, Mary Jan Greer

Summer 2024 OTD Capstone Symposium

Children with disabilities do not have as many opportunities to participate in sports and leisure activities as their peers do, which may cause them to miss out on the benefits that participating in these activities offer. There are many barriers that children with disabilities and their parents face when seeking out adaptive sports activities especially in schools. This capstone project addressed some of these barriers. A needs assessment was conducted at an elementary school, which helped guide the development and implementation of the adaptive sports program, which is discussed in detail.

Addressing The Gap In Discharge Planning From A Skilled Nursing Facility, Yaqui Del Rio, Amy Lyons-Brown

Summer 2024 OTD Capstone Symposium

This project aims to improve health management in skilled nursing facilities (SNFs) by developing and implementing a comprehensive evaluation tool designed to assess patients' readiness for discharge. The tool addresses critical factors often overlooked during discharge planning, helping to identify areas where patients may feel unprepared or uncertain. By focusing on these areas, the project seeks to enhance patient outcomes and support effective health management.

Increasing Participation For Children With Special Needs, Calvin Shin, Amy Lyons-Brown

Summer 2024 OTD Capstone Symposium

This capstone project focuses on increasing participation for children with special needs through community engagement and social interactions. The purpose of this program is to explore the needs of children with special needs and increase participation of children within the community. The goal of this project is to increase participation in children with special needs, provide opportunities for children to feel more inclusive, promote meaningful relationships between peers, parents, and staff, and improve overall quality of life.

The Experience Of Pet Ownership In Transitional Housing, Kathryn Holden Ots, Susan Macdermott Otd, Otr/L

Summer 2024 OTD Capstone Symposium

25% of people experiencing homelessness have pets, but few transitional housing programs allow pets (Rhoades et al., 2015); therefore, there is a gap in the literature about the experience of pet ownership during the transitional housing process. This study aimed to explore pet owners' experiences at a transitional housing site in San Diego County. The student interviewed two current dog owners and four recent dog owners. All participants prioritized their pets because it was their strongest relationship. The prioritization of their dogs positively and negatively influenced occupational engagement. While receiving services, owners experienced consequences when separated from their dogs, including …

Ot’S Role In Facilitating Foster Youth's Transition To College And Career Exploration, Stacey Tang, Amy Lyons-Brown

Summer 2024 OTD Capstone Symposium

Foster youths often face numerous adversities, limiting their occupational performance and ability to transition into adulthood, specifically regarding career and education. This poster explores the role of Occupational Therapy (OT) in supporting these youths as they age out of foster care, particularly focusing on college and career exploration. Using the Person-Environment-Occupation-Performance (PEOP) and KAWA River models, a needs assessment was conducted in collaboration with Foster Love, a non-profit organization. The assessment revealed gaps in resources and support for foster youths, leading to the development of workshops that foster self-reflection, emotional regulation, and goal setting as they navigate their transition into …

The Effectiveness And Safety Of Stellate Ganglion Block In The Treatment Of Symptoms From Long Covid-19: A Pilot Study, Alexa O Levey, Grant H Chen, Alexandra Ngyuen, Luis Ostrosky-Zeichner, Jamal Hasoon, Sepideh Saroukhani, Matthew Lin

Faculty, Staff and Student Publications

Purpose: Pilot study to evaluate the safety and effectiveness of stellate ganglion blocks in the treatment of symptoms related to long COVID infection.

Materials and methods: A total of 17 patients who underwent stellate ganglion block for the treatment of their long COVID symptoms were included. COMPASS-31, GAD-7, PCL-5, and Fatigue Severity Score (FSS) pre and post intervention surveys and data on baseline heartrate and post- block heart rate recorded in the EMR.

Results: A total of 94% of patients reported moderate-to-severe autonomic dysfunction pre-procedure as measured by COMPASS-31. All patients reported some degree of symptomatic improvement from the block. …

Multiple Guidance Mechanisms Control Axon Growth To Generate Precise T-Shaped Bifurcation During Dorsal Funiculus Development In The Spinal Cord, Bridget M. Curran, Kelsey R. Nickerson, Andrea R. Yung, Lisa V. Goodrich, Alexander Jaworski, Marc Tessier-Lavigne, Le Ma

Farber Institute for Neuroscience Faculty Papers

The dorsal funiculus in the spinal cord relays somatosensory information to the brain. It is made of T-shaped bifurcation of dorsal root ganglion (DRG) sensory axons. Our previous study has shown that Slit signaling is required for proper guidance during bifurcation, but loss of Slit does not affect all DRG axons. Here, we examined the role of the extracellular molecule Netrin-1 (Ntn1). Using wholemount staining with tissue clearing, we showed that mice lacking Ntn1 had axons escaping from the dorsal funiculus at the time of bifurcation. Genetic labeling confirmed that these misprojecting axons come from DRG neurons. Single axon analysis …

Treating Mothers With Postpartum Depression While In The Nicu, Arrie Belnap, Mary Jan Greer, Aimee Doughty

Summer 2024 OTD Capstone Symposium

The presentation is about an educational program developed to educate mothers with or at risk for postpartum depression (PPD) while their baby is in the neonatal intensive care unit (NICU). Mothers learned about the nature of PPD, occupations to implement to decrease symptoms of PPD, and occupations that they can participate in to care for their NICU babies. The evaluations, interventions, and outcomes of the program are discussed.

Vitamin D And Metabolic Bone Disease In Prolonged Continuous Kidney Replacement Therapy: A Prospective Observational Study., Peace Dorothy Imani, Molly Vega, Naile Tufan Pekkucuksen, Poyyapakkam Srivaths, Ayse Akcan Arikan

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: Complications of prolonged continuous kidney replacement therapy (CKRT) have not been well described. Our objective was to describe mineral metabolism and bone findings in children who required prolonged CKRT.

METHODS: In this single center prospective observational study, we enrolled 37 patients who required CKRT for ≥ 28 days with regional citrate anticoagulation. Exposure was duration on CKRT and outcomes were 25-hydroxy vitamin D and osteopenia and/or fractures.

RESULTS: The prevalence of vitamin D deficiency and insufficiency was 17.2% and 69.0%, respectively. 29.7% of patients had radiographic findings of osteopenia and/or fractures. There was no association between vitamin D deficiency …

Comparative Efficacy Of Endoscopic Ultrasound-Guided Biliary Drainage Versus Endoscopic Retrograde Cholangiopancreatography As First-Line Palliation In Malignant Distal Biliary Obstruction: A Systematic Review And Meta-Analysis, Shravya Reddy Ginnaram, Sudeep Nugooru, Dawood Tahir, Kara Devine, Ali Raza Shaikh, Pradeep Yarra, James Walter

Abington Jefferson Health Papers

BACKGROUND: Malignant distal biliary obstruction (MDBO) is a challenging clinical condition commonly managed with endoscopic retrograde cholangiopancreatography (ERCP). However, endoscopic ultrasound-guided biliary drainage (EUS-BD) has emerged as an alternative, especially in complex cases where ERCP fails or is deemed risky. This study aimed to compare the efficacy, safety and cost-effectiveness of EUS-BD vs. ERCP in the palliation of MDBO.

METHODS: We conducted a systematic review and meta-analysis, following PRISMA guidelines. Three databases were searched up to December 2023, including MEDLINE/PubMed, OVID and the Cochrane Central Register of Controlled Trials, for studies comparing EUS-BD with ERCP. Primary outcomes were technical and …

Novel 3,6-Disubstituted Pyridazine Derivatives Targeting Jnk1 Pathway: Scaffold Hopping And Hybridization-Based Design, Synthesis, Molecular Modeling, In Vitro And In Vivo Anticancer Evaluation., Mai M. Shaalan, Essam Eldin A. Osman, Yasmeen M. Attia, Olfat A. Hammam, Riham F. George, Bassem H. Naguib

Pharmacy

A series of novel 3,6-disubstituted pyridazine derivatives was designed, synthesized, and biologically evaluated as preclinical anticancer candidates. Compound 9e exhibited the highest growth inhibition against most of the NCI-60 cancer cell lines. The in vivo anticancer activity of 9e was subsequently investigated at two dose levels using the Ehrlich ascites carcinoma solid tumor animal model where a reduction in the mean tumor volume allied with necrosis induction was reported, without any signs of toxicity in the treated groups. Interestingly, compound 9e was capable of downregulating c-jun N-terminal kinase-1 (JNK1) gene expression and curbing the protein levels of its phosphorylated form, …

08.19.2024 Orsp Connect, Liz Williamson

ORED Newsletter

Lei Cao NSF award

FDP Meeting Summaries Available

August LINC Lunch

Collaboration Opportunities

Effects Of Dietary Nitrate Supplementation On High-Intensity Cycling Sprint Performance In Recreationally Active Adults: A Systematic Review And Meta-Analysis, Rachel Tan, Jordan K. Cass, Isabella G. Lincoln, Lauren E. Wideen, Madelyn J. Nicholl, Trevor J. Molnar, Lewis A. Gough, Stephen J. Bailey, Adam Pennell

All Faculty Open Access Publications

This systematic review and meta-analysis investigated the influence of dietary nitrate supplementation on performance metrics during cycling sprint exercise according to the PRISMA guidelines. Searches were conducted on MEDLINE, PubMed, ScienceDirect, Scopus, and SPORTDiscus databases up to September 2023. Inclusion criteria were healthy recreationally active men and women who consumed nitrate-rich and nitrate-deficient beetroot juice to assess performance outcomes of mean power, peak power, time-to-peak power, and minimum power during 30-s cycling sprints. Risk of bias was assessed using the Cochrane Risk of Bias 2 and TESTEX tools and funnel plots. A random effects model was performed on six studies …

Occupational Therapy’S Role In Addressing Wellness In Underserved Communities, Kimberlyna Chheang, Amy Lyons-Brown, Anna Saavedra

Summer 2024 OTD Capstone Symposium

This capstone project addresses sociodemographic disparities in community wellness and health services in Kern County, CA, focusing on underserved communities facing trauma and systemic inequalities. In collaboration with the Community Action Partnership of Kern (CAPK) and their East Kern Family Resource Center (EKFRC), it aims to lay the foundation for community-based, tailored interventions using occupational therapy (OT) to enhance community well-being and promote access to critical services to support wellbeing.

The Role Of Occupational Therapy With Neurodiversity-Inclusive Workplace Design​, Jasmine Hou, Susan Macdermott

Summer 2024 OTD Capstone Symposium

The purpose of this capstone project is to raise awareness and understanding of neurodiversity to foster neuroinclusive work environments. By addressing employment challenges faced by the neurodiverse community, occupational therapists can support neurodistinct adults who often lack accessible services to navigate the job cycle, promote opportunities for neurodistinct individuals to succeed in the workforce, and educate employers on neuroinclusive design.

Outdoor Recreation For People With Spinal Cord Injuries: An Educational Video Series, Siarra N. Walker, Steven M. Gerardi, Heather Rennerfeldt

Summer 2024 OTD Capstone Symposium

More than 15 million people globally are living with spinal cord injury (SCI). Only half of people with SCI engage in leisure activities and approximately 71% of the population reports dissatisfaction in their leisure participation. There are numerous intrinsic and extrinsic barriers that lead to these significant declines in leisure exploration and participation, including lack of knowledge and inaccurate accessible online information. In correlation with these barriers, occupational therapy practitioners underutilize leisure participation during the rehabilitation process for people with SCI and this is an underreported topic in the literature. Occupational therapy practitioners and people with SCI lack knowledge of …

Occupational Impact Of Urinary Incontinence, Hannah Case, Karen Park

Summer 2024 OTD Capstone Symposium

The purpose of this capstone project was to conduct a research study to identify if children with UI encountered occupational impacts due to their condition, as well as their caregivers. Twelve caregivers participated in an online survey investigating the occupational impact (supports, barriers, and limitations) of being a caregiver to a child who encounters UI. The survey addressed how their child’s UI affects various occupations. The findings indicate a significant impact on leisure participation and home management. The qualitative data was acquired through unobtrusive methods, including narratives, blogs, and lived experiences, to provide the perspective of how UI affects children. …