Medicine and Health Sciences Commons^™

Historical Redlining, Contemporary Gentrification, And Severe Maternal Morbidity In California, 2005-2018, Xing Gao, Rachel Morello-Frosch, Amani M. Nuru-Jeter, Jonathan M. Snowden, Suzan L. Carmichael, Mahasin S. Mujahid

OHSU-PSU School of Public Health Faculty Publications and Presentations

Importance Historically redlined neighborhoods may experience disinvestment, influencing their likelihood of gentrification, a process of neighborhood (re-)development that unequally distributes harms and benefits by race and class. Understanding the combined outcomes of redlining and gentrification informs how the mutually constitutive systems of structural racism and racial capitalism affect pregnancy outcomes. Objective To examine if historical redlining and contemporary gentrification is associated with increased severe maternal morbidity (SMM) odds. Design, Setting, and Participants This cross-sectional study used data from a statewide population-based sample of all live hospital births at 20 weeks’ gestation or more between 2005 and 2018 in California. Analysis …

Examining Daily-Self Weighing As A Stand-Alone Intervention For Obesity Management, Ashley Parish

All ETDs from UAB

Obesity is an epidemic that has substantial implications for both individuals with the disease as well as the healthcare system in the United States. Individuals with obesity are at increased risk for developing associated co-morbid conditions such as cardiovascular disease, type 2 diabetes, and some forms of cancer, which can affect quality of life and lead to mortality. There are many health behavior interventions which target weight loss, maintenance of weight loss, or weight gain prevention in those with obesity; however, interventions have unique barriers that can vary based on personal, environmental, and social factors. Primary care (PC) settings, which …

The C-Terminal 4cxxc-Type Zinc Finger Domain Of Cdca7 Recognizes Hemimethylated Dna And Modulates Activities Of Chromatin Remodeling Enzyme Hells, Akeo Shinkai, Hideharu Hashimoto, Chikako Shimura, Hiroaki Fujimoto, Kei Fukuda, Naoki Horikoshi, Masaki Okano, Hitoshi Niwa, Erik W Debler, Hitoshi Kurumizaka, Yoichi Shinkai

Department of Biochemistry and Molecular Biology Faculty Papers

The chromatin-remodeling enzyme helicase lymphoid-specific (HELLS) interacts with cell division cycle-associated 7 (CDCA7) on nucleosomes and is involved in the regulation of DNA methylation in higher organisms. Mutations in these genes cause immunodeficiency, centromeric instability, and facial anomalies (ICF) syndrome, which also results in DNA hypomethylation of satellite repeat regions. We investigated the functional domains of human CDCA7 in HELLS using several mutant CDCA7 proteins. The central region is critical for binding to HELLS, activation of ATPase, and nucleosome sliding activities of HELLS-CDCA7. The N-terminal region tends to inhibit ATPase activity. The C-terminal 4CXXC-type zinc finger domain contributes to CpG …

Dek::Aff2 Fusion-Associated Squamous Cell Carcinoma: A Case Series With Literature Review On An Emerging And Challenging Entity, Sara E Amin, James S Lewis, Julia A Bridge, Jen-Fan Hang, Udit Naik, Justin A Bishop, Karan Saluja

Faculty, Staff and Student Publications

Purpose: DEK::AFF2 fusion-associated squamous cell carcinoma (DEK::AFF2 SCC), also reported in the literature as low-grade papillary sinonasal (Schneiderian) carcinoma (LGPSC), is a rare, primarily bland-appearing, but locally aggressive neoplasm. Morphologically, these tumors can closely resemble sinonasal papilloma (SP), especially on small or limited biopsy, often leading to misdiagnosis. DEK::AFF2 SCC is devoid of the underlying mutually exclusive EGFR or KRAS driver mutations of SP, suggesting it may represent a distinct unique entity.

Methods: In this study, we conducted a retrospective search of "unusual" SP reported either as atypical, dysplastic, or suspicious for malignant transformation at our institution in the last …

Thrombectomy For Stroke With Large Infarct On Noncontrast Ct: The Tesla Randomized Clinical Trial, Writing Committee For The Tesla Investigators, Albert J Yoo, Osama O Zaidat, Sunil A Sheth, Ansaar T Rai, Santiago Ortega-Gutierrez, Curtis A Given, Syed F Zaidi, Ramesh Grandhi, Hugo Cuellar, Maxim Mokin, Jeffrey M Katz, Amer Alshekhlee, Muhammad A Taqi, Sameer A Ansari, Adnan H Siddiqui, Nobl Barazangi, Joey D English, Alberto Maud, Jawad Kirmani, Rishi Gupta, Dileep R Yavagal, Jason Tarpley, Dhruvil J Pandya, Marshall C Cress, Sushrut Dharmadhikari, Kaiz S Asif, Tareq Kass-Hout, Ajit S Puri, Nazli Janjua, Aniel Q Majjhoo, Aamir Badruddin, Randall C Edgell, Rakesh Khatri, Larry Morgan, Anmar Razak, Alicia Zha, Priyank Khandelwal, Nils Mueller-Kronast, Dennis J Rivet, Thomas Wolfe, Brian Snelling, Ali Sultan-Qurraie, Shao-Pow Lin, Rajkamal Khangura, Alejandro M Spiotta, Parita Bhuva, Sergio Salazar-Marioni, Eugene Lin, Abdul R Tarabishy, Edgar A Samaniego, Murali K Kolikonda, Mouhammad A Jumaa, Vivek K Reddy, Pankaj Sharma, Olvert A Berkhemer, Pieter-Jan Van Doormaal, Adriaan C G M Van Es, Wim H Van Zwam, Bart J Emmer, Ludo F Beenen, Charles B L M Majoie, Nancy Buderer, Michelle A Detry, Anna Bosse, Todd L Graves, Christina Saunders, Lucas Elijovich, Ashutosh Jadhav, Mary Patterson, Hannah Slight, Kristine Below, Sami Al Kasab, Tesla Investigators

Faculty, Staff and Student Publications

Importance: Recent large infarct thrombectomy trials used heterogeneous imaging modalities and time windows for patient selection. Noncontrast computed tomographic (CT) scan is the most common stroke imaging approach. It remains uncertain whether thrombectomy is effective for patients with large infarcts identified using noncontrast CT alone within 24 hours of stroke onset.

Objective: To evaluate the effect of thrombectomy in patients with a large infarct on a noncontrast CT scan within 24 hours of onset.

Design, setting, and participants: Open-label, blinded-end point, bayesian-adaptive randomized trial with interim analyses for early stopping (futility or success) or population enrichment, which was conducted at …

Metadegron: Multimodal Feature-Integrated Protein Language Model For Predicting E3 Ligase Targeted Degrons, Mengqiu Zheng, Shaofeng Lin, Kunqi Chen, Ruifeng Hu, Liming Wang, Zhongming Zhao, Haodong Xu

Faculty, Staff and Student Publications

Protein degradation through the ubiquitin proteasome system at the spatial and temporal regulation is essential for many cellular processes. E3 ligases and degradation signals (degrons), the sequences they recognize in the target proteins, are key parts of the ubiquitin-mediated proteolysis, and their interactions determine the degradation specificity and maintain cellular homeostasis. To date, only a limited number of targeted degron instances have been identified, and their properties are not yet fully characterized. To tackle on this challenge, here we develop a novel deep-learning framework, namely MetaDegron, for predicting E3 ligase targeted degron by integrating the protein language model and comprehensive …

Mta-Cooperative Prmt5 Inhibitors Enhance T Cell-Mediated Antitumor Activity In Mtap-Loss Tumors, Si Chen, Jiakai Hou, Roshni Jaffery, Ashley Guerrero, Rongjie Fu, Leilei Shi, Ningbo Zheng, Ritu Bohat, Nicholas A Egan, Chengtai Yu, Sana Sharif, Yue Lu, Wei He, Shuyue Wang, Donjeta Gjuka, Everett M Stone, Pooja Anil Shah, Jordi Rodon Ahnert, Taiping Chen, Xinli Liu, Mark T Bedford, Han Xu, Weiyi Peng

Faculty, Staff and Student Publications

BACKGROUND: Hyperactivated protein arginine methyltransferases (PRMTs) are implicated in human cancers. Inhibiting tumor intrinsic PRMT5 was reported to potentiate antitumor immune responses, highlighting the possibility of combining PRMT5 inhibitors (PRMT5i) with cancer immunotherapy. However, global suppression of PRMT5 activity impairs the effector functions of immune cells. Here, we sought to identify strategies to specifically inhibit PRMT5 activity in tumor tissues and develop effective PRMT5i-based immuno-oncology (IO) combinations for cancer treatment, particularly for methylthioadenosine phosphorylase (MTAP)-loss cancer.

METHODS: Isogeneic tumor lines with and without MTAP loss were generated by CRISPR/Cas9 knockout. The effects of two PRMT5 inhibitors (GSK3326595 and MRTX1719) were …

Strategic Stabilization Of Arousal Boosts Sustained Attention, Jan Willem De Gee, Zakir Mridha, Marisa Hudson, Yanchen Shi, Hannah Ramsaywak, Spencer Smith, Nishad Karediya, Matthew Thompson, Kit Jaspe, Hong Jiang, Wenhao Zhang, Matthew J Mcginley

Duncan NRI Faculty and Staff Publications

Arousal and motivation interact to profoundly influence behavior. For example, experience tells us that we have some capacity to control our arousal when appropriately motivated, such as staying awake while driving a motor vehicle. However, little is known about how arousal and motivation jointly influence decision computations, including if and how animals, such as rodents, adapt their arousal state to their needs. Here, we developed and show results from an auditory, feature-based, sustained-attention task with intermittently shifting task utility. We use pupil size to estimate arousal across a wide range of states and apply tailored signal detection theoretic, hazard function …

The Centrosomal Protein Fgfr1op Controls Myosin Function In Murine Intestinal Epithelial Cells, Tihana Trsan, Vincent Peng, Takahiro E Ohara, Wandy L Beatty, Raki Sudan, Praveen Krishnamoorthy, Patrick Fernandes Rodrigues, Jose L Fachi, Gary Grajales-Reyes, Natalia Jaeger, James A J Fitzpatrick, Marina Cella, Susan Gilfillan, Marco Colonna, Et Al.

2020-Current year OA Pubs

Recent advances in human genetics have shed light on the genetic factors contributing to inflammatory diseases, particularly Crohn's disease (CD), a prominent form of inflammatory bowel disease. Certain risk genes associated with CD directly influence cytokine biology and cell-specific communication networks. Current CD therapies primarily rely on anti-inflammatory drugs, which are inconsistently effective and lack strategies for promoting epithelial restoration and mucosal balance. To understand CD's underlying mechanisms, we investigated the link between CD and the FGFR1OP gene, which encodes a centrosome protein. FGFR1OP deletion in mouse intestinal epithelial cells disrupted crypt architecture, resulting in crypt loss, inflammation, and fatality. …

Scientific Programs In The Arab Media - Reality And Gap, Najm Abed Khalaf Aleessawi

Middle East Journal of Communication Studies

The article aimed to reveal the level of Arab media coverage of specialized scientific topics and to know the actual need for such programs, especially with the tremendous developments in various fields of life. The descriptive analytical approach was adopted, and a questionnaire tool was used, which was distributed to (205) Arab academics and researchers who were selected by a simple random sampling method. The study found that coverage of scientific programs in the Arab media at the local level is not at the required level. Social media platforms are the most widely used media means for accessing scientific programs …

A Comparison Of Manual And Automatic Force-Onset Identification Methodologies And Their Effect On Force-Time Characteristics In The Isometric Midthigh Pull, Stuart N. Guppy, Claire J. Brady, Yosuke Kotani, Shannon Connolly, Paul Comfort, Jason P. Lake, G. Gregory Haff

Research outputs 2014 to 2021

The aim of this study was to assess the agreement of three different automated methods of identifying force-onset (40 N, 5 SDs, and 3 SDs) with manual identification, during the isometric mid-thigh pull (IMTP). Fourteen resistance-trained participants with > 6 months experience training with the power clean volunteered to take part. After three familiarisation sessions, the participants performed five maximal IMTPs separated by 1 min of rest. Fixed bias was found between 40 N and manual identification for time at force-onset. No proportional bias was present between manual identification and any automated threshold. Fixed bias between manual identification and automated was …

Ai In The Health Professions, Heidi Monroe, Carrie Fry, Phillip Baker, Erika Busz

AI and the Future of Work

The aim of this track is to provide health professionals, and those interested in mental health and healthcare careers with an understanding of key aspects of AI use in healthcare. Participants will explore advantages of some recent AI developments and evaluate how they may be effectively leveraged to improve patient care, while addressing potential challenges, limitations, and ethical considerations.

Differential Analysis Of The Impact Of Lesions’ Location On Clinical And Radiological Outcomes After The Implantation Of A Novel Aragonite-Based Scaffold To Treat Knee Cartilage Defects, Pietro Conte, Giuseppe Anzillotti, Dennis C. Crawford, Vinod Dasa, David C. Flanigan, William E. Nordt, Jason M. Scopp, Robert J. Meislin, Eric J. Strauss, Sabrina M. Strickland, Gennaro Fiorentino, Christian Lattermann

School of Medicine Faculty Publications

Purpose: There is limited comparative evidence on patient outcomes following cartilage repair in various knee compartments. The aim of this study was to compare clinical and imaging outcomes after treating cartilage defects in femoral condyles and trochlea with either an aragonite-based scaffold or surgical standard of care (SSoC, i.e., debridement/microfractures) in a large multicentre randomized controlled trial. Methods: 247 patients with up to three knee joint surface lesions (ICRS grade IIIa or above) in the femoral condyles, trochlea or both (“mixed”), were enrolled and randomized to surgery with either a cell-free aragonite scaffold or SSoC. Patients were followed for up …

Phytotherapeutic Approach To Enhance The Hepatoprotective Activity Of Some Edible Plants: Molecular Docking And Nanoformulation, Khaled Nematallah, Amgad Albohy, Noha Swilam

Pharmacy

This study used molecular docking to evaluate phytochemicals from 47 plants against liver fibrosis. It identified potent compounds, prompting further investigation of chamomile, pomegranate, ginseng, and artichoke. Extracts from these plants were characterized and formulated into a self-microemulsifying drug delivery system (SMEDDS). Studies on the herbal formula exhibited around 150% higher flavonoids, 50% higher polyphenols, 178% higher antioxidant activity, and synergistic In-vitro hepatoprotective effects compared to the average results of individual extracts. Both the aqueous suspension and the nanoformulation of the formula offered in-vivo protection against paracetamol-induced hepatotoxicity in mice. The SMEDDS group showed superior outcomes, with no significant differences …

Phytotherapeutic Approach To Enhance The Hepatoprotective Activity Of Some Edible Plants: Molecular Docking And Nanoformulation, Khaled Nematallah, Amgad Abdallah, Noha Swilam

Pharmacy

This study used molecular docking to evaluate phytochemicals from 47 plants against liver fibrosis. It identified potent compounds, prompting further investigation of chamomile, pomegranate, ginseng, and artichoke. Extracts from these plants were characterized and formulated into a self-microemulsifying drug delivery system (SMEDDS). Studies on the herbal formula exhibited around 150% higher flavonoids, 50% higher polyphenols, 178% higher antioxidant activity, and synergistic In-vitro hepatoprotective effects compared to the average results of individual extracts. Both the aqueous suspension and the nanoformulation of the formula offered in-vivo protection against paracetamol-induced hepatotoxicity in mice. The SMEDDS group showed superior outcomes, with no significant differences …

Financial Toxicity In Breast Cancer Patients Receiving Regional Nodal Irradiation: Variation By Cancer Subtype, Grace L Smith, Benjamin D Smith, Chi-Fang Wu, Simona F Shaitelman, Mariana Chavez-Macgregor, Rashmi Murthy, Kelsey Kaiser, Kimberly S Ku, Julia J Shi, Sanjay S Shete, Ying-Shiuan Chen, Robert J Volk, Sharon H Giordano, Ya-Chen T Shih, Karen E Hoffman

Faculty, Staff and Student Publications

BACKGROUND: We evaluated sociodemographic and clinical predictors of financial toxicity (FT) among patients with breast cancer with higher risk clinical factors warranting regional nodal irradiation (RNI).

METHODS: Among 183 participants in a clinical trial of conventional vs. hypofractionated treatment with RNI, 125 (68 %) completed a pilot survey of FT measured using the validated Economic Strain and Resilience in Cancer (ENRICh) instrument, scored from 0 (minimal) to 10 (severe) FT. Associations with predictors were evaluated using Pearson correlation coefficients and Kruskal Wallis, Mann-Whitney U, and Jonckheere-Terpstra tests. Predictors of severe FT (ENRICh≥5) were tested using multivariable logistic regression with odds …

Perceived Anxiety Disorder Stigma: A Predictive Analysis, Shawn Nabors, Richard J. Cicchetti, Gary Michael Szirony, Craig R. Blum, Sri Banerjee

Journal of Social, Behavioral, and Health Sciences

Anxiety remains one of the most commonly diagnosed mental health disorders. Systemic barriers to mental health treatment persist. Research on anxiety is robust, although research on perceived anxiety disorder stigma is limited. The purpose of this quantitative analysis was to determine whether factors including age, gender, level of education, and presence of a diagnosable anxiety disorder condition would predict perceived anxiety stigma in a population of adults from the Midwestern region of the United States who were in treatment for anxiety. Based on Goffman’s framework, we used the Generalized Anxiety Stigma Scale (GASS) to determine the presence and level of …

Examining Management And Employees' Perceptions Of Occupational Heat Exposure And The Effectiveness Of A Heat Stress Prevention Intervention On Safety And Well-Being Among Natural Gas Construction Workers: A Qualitative Field-Based Study, Muinat Abolore Idris, Christine Markham, Kristina D Mena, William B Perkison

Faculty, Staff and Student Publications

BACKGROUND: Numerous risk factors have been identified as significantly influencing outdoor workers' risk for heat stress and heat-related conditions, impacting their health, well-being, and productivity. However, the specific effects of these factors on construction workers' safety, health, and well-being remain under-researched. With climate change increasing temperatures, assessing heat stress among construction workers is imperative.

OBJECTIVE: To identify the barriers and facilitators influencing the safety of natural gas construction workers and evaluate an implemented heat stress intervention.

METHODS: In the summer of 2023, two semi-structured interviews and six focus groups were conducted with twenty-one stakeholders at a Texas natural gas construction …

Lactate/Pyruvate Ratio As An Early Predictor Of Mortality In Patients With Sepsis: A Cohort Study, Olga G. Cantu-Rodriguez, Jose A. Hawing-Zarate, Edgar Dorsey Trevino, David Hernandez-Barajas, Leonel E. Villalobos-Gutierrez, Jose Carlos Jaime-Perez, Consuelo Mancias-Guerra, Oscar Gonzalez-Llano, Graciela A. Gonzalez-Cantu, David Gomez-Almaguer, Cesar H. Gutierrez-Aguirre

School of Medicine Publications

Background: The lactate/pyruvate (LP) ratio has been studied as an alternative to serum lactate to determine clinical prognosis. Despite its clinical utility, there is a paucity of evidence evaluating the role of the L/P ratio in patients with sepsis. Methods: We assessed the clinical utility of the L/P ratio in patients with sepsis. The L/P ratio was measured at baseline, 4 and 8 h after admission. Our primary outcome was to determine the prognostic utility of the L/P ratio on the 15-day mortality risk. Our secondary outcomes were to compare the L/P ratio across time and its prognostic utility against …

Characterizing Undiagnosed And Incident Stis In An Hiv Vaccine Trial Cohort In South Africa (Hvtn 702), Hermione Yamyo Monie, Adrienne Shapiro, Fatima Laher, Ayman Osman

Research Colloquium

Background: According to the World Health Organization (WHO), sub-Saharan Africa leads the world in incidence rates of chlamydia, gonorrhea, and trichomonas1. Sexually transmitted infections (STIs) are associated with reduced quality of life, neonatal deaths and increased disease susceptibility. Despite efforts in public health, among those with STIs, the risk of contracting HIV remains at an all-time high2.

The aim of this secondary analysis was to extrapolate the prevalence and incidence of STIs, within a cohort, as supporting evidence to guide future public health efforts and resources.

Methods This analysis was conducted as a cross-sectional and longitudinal examination of the data …

The Association Of Apathy With Functional And Cognitive Impairment In Individuals With Biomarker Confirmed Alzheimer’S Disease Pathology, Megan Engeland

Yale School of Medicine Physician Associate Program Theses

Objectives: Apathy is one of the most common neuropsychiatric symptoms in patients with Alzheimer’s Disease (AD) and has been shown to be associated with greater impairments in daily functional and cognitive status. Previous studies have used subjects with a clinical diagnosis of AD, without biomarker information, and did not control for potential confounding factors. Design: To evaluate the prevalence of apathy in a biomarker informed cross-sectional study of AD and the association of apathy with functional and cognitive status. Setting: Data used in this study was obtained from the Yale Alzheimer’s Disease Research Unit (ADRU) database. Participants …

Resuming Anticoagulation In High Thrombotic Risk Patients After Traumatic Intracranial Hemorrhage, Elijah Adams

Yale School of Medicine Physician Associate Program Theses

Background: The purpose of this study was to examine whether patients, previously on anticoagulation (AC) therapy who have sustained traumatic intracranial hemorrhage (tICrH), had less composite thrombotic or hemorrhagic events from earlier resumption of AC therapy compared to patients resumed later. Methods: In this retrospective observational study, we explored the median time to AC resumption in patients who were admitted for tICrH. The median was used as the cutoff point for defining early vs. late resumption of AC. Patients were categorized into early if resumption occurred between 14 and 23 days, late if resumption occurred between 24-120 days, and never …

Providing End-Of-Life Counseling: A Narrative Inquiry, Carol Hecht, Sibyl West

Adultspan Journal

This qualitative study aimed to address the gap in the research related to end-of-life counseling by exploring the experiences of counselors working with clients at end of life. While counseling literature and education are lacking regarding end of life, many counselors will work alongside clients approaching death. The purpose of this study was twofold: (a) to better understand the nuanced experiences of counselors providing end-of-life counseling and (b) to explore the supports and preparations helpful for counselors to provide end-of-life counseling. A narrative approach, using the Listening Guide (Gilligan, 2015), was employed to analyze and present the stories of three …

Considerations Of Medicare Telehealth Services With Older Adults, Sonah Kho, Amanda Dediego

Adultspan Journal

The onset of the COVID-19 pandemic set in motion a rapid expansion of mental health services offered via telehealth. With this rapid expansion came the need to examine how policy and practice should be shaped in a future where telehealth is considered common in counseling practice. For counselors to understand how to support older adult clients in using telehealth services, they must understand telehealth policy. Following the eligibility of licensed counselors to participate in Medicare, counselors need to stay abreast of regulatory changes regarding restrictions and regulations on use of telehealth for mental and behavioral health services, including video and …

Nmosd Mitochondrial Fluorescence Correlates With Ganglion Cell Layer Loss Consistent With Retinal Vasculitis, Francesco Cappellani, Md, Daniel M. Markowitz, Bs, Elizabeth Affel, Ms, Jose S. Pulido, Md, Brian Fernandez, Md, Robert C. Sergott, Md

Farber Institute for Neuroscience Staff Papers and Presentations

Introduction

• Fluorescence lifetime imaging ophthalmoscopy (FLIO, Heidelberg Engineering, Figures 1 and 2), a novel in vivo retinal imaging biomarker, generates fluorescence decay lifetimes in 2 spectral channels corresponding to mitochondrial metabolic processes
• Short Spectral Channel (SSC): 498 – 560 nm Ø Corresponds to flavin adenine dinucleotide (FAD) and oxidative phosphorylation.
• Long Spectral Channel (LSC): 560 – 720nm Ø Corresponds to predominantly lipofuscin and lysosomal function
• Based upon animal experimental models and clinical data, mitochondrial dysfunction has a role in the pathophysiology of NMOSD

Medical School Watercooler Newsletter - September 20, 2024, Lindsay Hughes

Watercooler Newsletter

This is the Friday, September 20, 2024 edition of the Frederick P. Whiddon College of Medicine's newsletter -- Watercooler. 

• Sign up for spring 2025 cohort of Academic Medicine Coach Training Program
• Now online: Read the new issue of USA Health magazine
• Custodio recognized at American Academy of Pediatricians Alabama Chapter meeting
• Surgeon with interest in weight-loss procedures joins faculty
• USA receives $5 million gift for Whiddon College of Medicine building

Uncovering The Complexity Of Perinatal Polysubstance Use Disclosure Patterns On X: Mixed Methods Study, Dezhi Wu, Hannah Shead, Yang Ren, Phyllis Raynor Phd, Aprn, Pmhnp-Bc, Youyou Tao, Harvey Villanueva, Peiyin Hung, Xiaoming Li, Robert G. Brookshire, Kacey Eichelberger, Constance Guille, Alain H. Litwin, Bankole Olatosi Ph.D.

Publications

BACKGROUND: According to the Morbidity and Mortality Weekly Report, polysubstance use among pregnant women is prevalent, with 38.2% of those who consume alcohol also engaging in the use of one or more additional substances. However, the underlying mechanisms, contexts, and experiences of polysubstance use are unclear. Organic information is abundant on social media such as X (formerly Twitter). Traditional quantitative and qualitative methods, as well as natural language processing techniques, can be jointly used to derive insights into public opinions, sentiments, and clinical and public health policy implications. OBJECTIVE: Based on perinatal polysubstance use (PPU) data that we extracted on …

Acute Liver Failure Induced By Menopausal Supplement, Rahul Patel, Ahmed Hassan, Hayle Scanlan, Matthew Everwine, Zhiyong Ren, Charles Snyder, Hisham Elgenaidi

School of Medicine Faculty Publications

Drug-induced liver injury is one of the most common causes of acute liver failure in the Western world. Despite discontinuation of the offending agent, it can still tax a grim prognosis. We describe a case of a menopausal woman taking a herbal supplement to relieve hot flashes and bloating. This is the first case report of liver injury from this supplement. She initially presented with mild jaundice and elevated transaminases. Unfortunately, she rapidly progressed to encephalopathy, experienced multiorgan failure, and then died.

10-02-24 Hsc Committee Meeting Notice, Helen Maestas

HSC Committee (A subcommittee of the UNM Board of Regents)

No abstract provided.

Paediatric Mass Casualty Response Through The Lens Of Functional Resonance Analytical Methodology- Lessons Learned., R J Mackinnon, D Slater, R Jenner, T Stenfors, Christopher S. Kennedy, K P Härenstam

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: Mass Casualty Incidents are rare but can significantly stress healthcare systems. Functional Resonance Analytical Methodology (FRAM) is a systematic approach to model and explore how complex systems adapt to variations and to understand resilient properties in the face of perturbations. The aim of this study was to use FRAM to create a model of a paediatric trauma system during the initial response to the Manchester Arena Attack to provide resilience-based insights for the management of future Mass Casualty Incidents (MCI).

METHODS: Qualitative interviews in the immediate aftermath of a terrorist bombing, were followed up with further in-depth probing of …