Medicine and Health Sciences Commons^™

Novel Ox40 And 4–1bb Derived Spacers Enhance Cd30 Car Activity And Safety In Cd30 Positive Lymphoma Models, Lindsay Kua, Chee Hoe Ng, Jin Wei Tan, Hwee Ching Tan, Cheah Chen Seh, Fiona Wong, Richard Ong, Cliona M Rooney, Joel Tan, Qingfeng Chen, Ivan D Horak, Kar Wai Tan, Lionel Low

Faculty, Staff and Students Publications

The chimeric antigen receptor (CAR) derived from the CD30 specific murine antibody, HRS-3, has produced promising clinical efficacy with a favorable safety profile in the treatment of relapsed or refractory CD30-positive lymphomas. However, persistence of the autologous CAR-T cells was brief, and many patients relapsed a year after treatment. The lack of persistence may be attributed to the use of a wild-type immunoglobulin (Ig)G1 spacer that can associate with Fc receptors. We first identified the cysteine-rich domain (CRD) 5 of CD30 as the primary binding epitope of HRS-3 and armed with this insight, attempted to improve the HRS-3 CAR functionality …

"I Just Had To Do What I Had To Do": Characterizing Direct And Indirect Prostate Cancer Treatment Costs For Black Survivors And Their Caregivers, Hannah E Rice, Allison J L'Hotta, Amela Siječić, Bettina F Drake, Su-Hsin Chang, Eric H Kim, Robin Wright-Jones, Mellve Shahid, Camille Neal, Ashley J Housten

2020-Current year OA Pubs

UNLABELLED:

HIGHLIGHTS: Direct and indirect costs have a wide-ranging impact on the material, behavioral, and psychosocial aspects of financial well-being of Black prostate cancer survivors and their caregivers.These results emphasize the need for sharing cost information to support medical decision making.Future research should focus on the design of cost-sharing interventions that target the complexities of direct and indirect costs collectively, rather than separately.

Beyond Assistance: Amplifying The Lived Experiences Of Marginalized Communities Navigating Support Service Systems In Mississippi, Karla Mccullough, Rodney Washington, Angela A. Omondi

Journal of Public Health in the Deep South

Background

Perceived dehumanizing experiences when interacting with social assistance caseworkers and providers can contribute to negative perceptions of the service system that may impede enrollment and retention of families in need thereby contributing to health disparities.

Purpose

This study aimed to use secondary analysis of qualitative data to explore the interaction between social services workers/providers and recipients from the perspectives of families seeking social support services in Mississippi.

Methods

This study analyzed secondary qualitative data from a sample of (n=15) representatives in Mississippi. Data was analyzed using a thematic analysis approach.

Results

Participants reported perceived dehumanized experiences such …

A Model For Developing Emergency Medical Services Instructor Knowledge, David Hall, Lisa Fee

Journal of Public Health in the Deep South

PROBLEM: The task of educating Emergency Medical Services (EMS) providers requires EMS instructors to possess and convey translational knowledge and skills relevant to out-of-hospital emergency care. Insufficiently prepared or new EMS instructors may lack translational knowledge and skills along these lines and be at a deficit when it comes to educating EMS providers. PURPOSE: The project involved creation, implementation, and analysis of a model state EMS instructor core training program in Mississippi, with the aim of developing translational knowledge and skills for use by EMS instructors. METHOD: The project utilized a revised Evidence-Based Practice (EBP) model and a standardized survey …

Public Support For Tobacco Control Policies Among Mississippi Adults, Emily Mcclelland, Tiffany Johnson, Robert Mcmillen

Journal of Public Health in the Deep South

Background: Smoking kills 5,000 Mississippi adults per year and more than a third of cancer deaths are attributable to smoking. The annual healthcare costs to Mississippi due to smoking are $1.43 billion.

Purpose: Assess public support for policies that reduce tobacco use.

Methods: Telephone surveys were administered to a representative sample of 900 Mississippi adults in 2023. Participants were asked about their support or opposition to implementing a statewide smokefree law, restricting where people can vape, increasing the state cigarette tax, taxing e-cigarettes, and restricting e-cigarette advertising.

Results: The majority of respondents support each of these five policies, with an …

Teachers’ Perceptions Of An Integrated Nutrition Education Curriculum And The Impact On Preschoolers' Food Liking, Alicia Stapp, Laurel Lambert, Georgianna Mann, Kaitlyn Sills, Kenya Wolff

Journal of Public Health in the Deep South

Background: Nutrition education during early childhood that includes experiential learning, modeling, and family engagement can support lifelong healthy eating habits.

Purpose: The present study examined the impact of a nutrition-integrated, 32-week supplemental curriculum entitled Growing Healthy Minds, Bodies, and Communities on children’s exposure to fruits and vegetables, ability to identify fruits and vegetables, liking of fruit and vegetables, and teachers’ perceptions of the curriculum.

Methods: A pre- and post- fruit and vegetable pictorial Likert survey was administered to 261 Pre-K4 children. To investigate teachers’ perceptions of the curriculum, a post-intervention focus group was conducted with 19 teachers.

Results: Significant differences …

The Prevalence Rate Of Syphilis And Hiv Across Different Genders, Races, And Ages From 2017 To 2021 In The Southern Region Of The United States, Nafiseh Gavari, Rita Momah, Jessica Green Collins, Elizabeth Jones

Journal of Public Health in the Deep South

This study investigates the prevalence rates of Syphilis and HIV across different genders, races, and ages from 2017 to 2021 in regions 4 (Kentucky, North Carolina, Mississippi, Tennessee, South Carolina, Georgia, Florida, and Alabama) and 6 (New Mexico, Oklahoma, Texas, Arkansas, and Louisiana). These regions have been identified as high-risk areas for sexually transmitted diseases (STDs). Our study seeks to shed light on the trends and disparities in STD prevalence within these specific regions over the specified timeframe. Data were collected and analyzed from the AtlasPlus database, providing insights into the epidemiology of these diseases. The findings reveal increasing trends …

Social Determinants Of Alzheimer’S Disease And Dementia: The Mississippi Landscape, Kenneth R. Butler Jr., Denise Lafferty, Stacee B. Naylor, Kimberly C. Tarver Md

Journal of Public Health in the Deep South

Social determinants of health (SDOH) are those conditions in the environment where people are born, live, learn, work, play, worship, and age that affect a wide range of health, physical and cognitive functions, and quality-of-life outcomes and risks. Numerous social factors are significant contributors to the development and progression of various diseases. Recently, much attention has focused on assessing the impact of social factors on Alzheimer's disease and related dementias (ADRD). The objective of this commentary is to describe and assess the SDOH that have been associated with increased risk of ADRD in the context of the social environment in …

The Jackson Water Crisis Across The Lifespan: Living And Dying For Clean Water, Ashley W. Jones, Antonio J. Gardner

Journal of Public Health in the Deep South

At the height of the COVID-19 pandemic and in the midst of freezing temperatures from a snowstorm, the city of Jackson, MS faced the potential demise of its drinking water infrastructure. Triggered by the freezing of water pipes in the city and a subsequent fire at a local water treatment facility, the lack of clean, accessible water made daily tasks more difficult for the city’s older adult population who had limited mobility, income, and ability to relocate. This commentary examines the effects of ongoing water infrastructure issues in Jackson, MS and its effect on aging in place. Considerations for a …

Library & Knowledge Services Newsletter - Fall 2024, Baystate Health Sciences Library

Library Newsletters

Library & Knowledge Services Newsletter - Fall 2024

Improving Certified Registered Nurse Anesthetists' Preparedness And Intention To Serve On Boards., Jana Bailey

Doctor of Nursing Practice Papers

Abstract

Background: The project was driven by expressed interest in serving on boards by 171 Certified Registered Nurse Anesthetists (CRNAs), expressed lack of preparation, and nurses on boards (NOB) literature recommendations to improve preparation through professional development.

Purpose: To implement a NOB preparation microlearning program for CRNAs who desire to serve on boards but feel unprepared to do so, improve CRNA participants' preparedness and intention to serve on boards, evaluate application of NOB learning, and offer continuing education credit.

Methods: A pre-test/post-test design was used to evaluate preparedness (Sundean Healthcare Index for Preparation in Board Competency [SHIP-BC^©]; Sundean, …

Ethical Requirements For Achieving Fairness In Radiology Machine Learning: An Intersectionality And Social Embeddedness Approach, Dessislava S. Fessenko

Journal of Health Ethics

Radiodiagnostics by machine-learning (ML) systems is often perceived as objective and fair. It may, however, exhibit bias towards certain patient sub-groups. The typical reasons for this are the selection of disease features for ML systems to screen, that ML systems learn from human clinical judgements, which are often biased, and that fairness in ML is often inappropriately conceptualized as “equality”. ML systems with such parameters fail to accurately diagnose and address patients’ actual health needs and how they depend on patients’ social identities (i.e. intersectionality) and broader social conditions (i.e. embeddedness). This paper explores the ethical obligations to ensure fairness …

Steatotic Mass Secondary To Heterozygous Hemochromatosis, A Rare Case Of Biliary Obstruction, Saddam Zaidi Md, Cheng-Hung Tai, Joanna Gibson Md, Phd, Caroline Loeser

Posters

Heterozygous Hemochromatosis (HH) is a genetic disorder that increases iron absorption. Carriers of the C282Y HFE gene mutation have a higher risk of developing nonalcoholic fatty liver disease (NAFLD). Research indicates a significant association between liver fat accumulation (steatosis) and fibrosis in HH. This case involves a 31-year-old male with HH and an uncommon biliary obstruction caused by focal fat infiltration.

A Rare Case Of Metachronous Gastric Lymphoma And Gastric Adenocarcinoma, Rofinna Johnkennedy Md, Mph, Cheng-Hung Tai, Alexa Plato Md, Department Of Medicine,, Caroline Loeser

Posters

Reports of metachronous primary gastric lymphoma and gastric adenocarcinoma exist in the literature, but it remains a rare entity. We present a rare case of metachronous gastric adenocarcinoma in a patient diagnosed initially with primary gastric lymphoma.

Amyloidosis: A Rare Cause Of Pan-Dysmotility, Rofinna Johnkennedy Md, Mph, Cheng-Hung Tai, Alexa Plato Md, Department Of Medicine,

Posters

Amyloidosis is a rare systemic infiltrative disease, with a prevalence estimated to be 6-10 cases per million person-years. It involves the extracellular deposition of beta-sheet fibrillar protein and can manifest in any organ system in the body. Diagnosis of gastrointestinal involvement of amyloidosis can be difficult, given its nonspecific symptoms including abdominal pain, nausea, dysphagia, and diarrhea.

Undergraduate Nursing Students’ Simulation Experiences With End-Of-Life Care In A Rural Setting: A Scoping Review, Christopher Norman Msn, Aprn, Gnp-Bc, Jodi Sutherland Phd, Rn, Acrn, Cne, Lori Marie Sprague Phd, Rn, Chse, Deborah Palmer Ms, Rn, Alma Rood Msn, Rn, Laura Lipke Ms, Mlis, Ahip

Nursing Faculty Scholarship

Objective: The purpose of this scoping review is to provide nurse educators and nurse leaders in practice with the findings on the state of the science surrounding undergraduate nursing education simulation-based experiences focused on end-of-life (EOL) care in rural settings. This scoping review aims to identify undergraduate nursing student experiences with EOL care in the rural setting and identify key simulation-based educational strategies utilized in undergraduate nursing programs to inform educational programs about simulation practices. The outcome of this review is intended to advance nursing education to better prepare future nurses for practice and to develop competence in providing EOL …

Stronger Together, Loma Linda University Health

Scope

Features:

2 | From the President - Stronger, Thanks to You
4 | Loma Linda University Cancer Center
6 | Loma Linda University Children's Health
8 | Loma Linda University School of Nursing
10 | Loma Linda University School of Dentistry
12 | University Village
14 | Additional Stronger Together Initiatives

Santa Clara Magazine, Volume 65 Number 2, Fall 2024 [Print Issue 62:2], Santa Clara University

Santa Clara Magazine

12 - INCREASING ACCESS Discerning one’s dream requires a whole set of experiences based on community, opportunity, and, yes, cash. Leslie Griffy

16 - UNPACKING UTOPIA It seems like billionaire-backed utopias are popping up all over the map. What does it take to build a perfect city? Lauren Loftus

22 - A WEALTH OF WELL-BEING In his new book, Professor Meir Statman explores a holistic approach to financial and life well-being. Leslie Griffy

26 - A WOMAN'S PLACE Despite being denied access to the priesthood, Catholic women find new ways to lead. Leslie Griffy

Risk Of Stroke In Patients With Left Ventricular Thrombosis Who Undergo Coronary Angiography: A System-Wide Retrospective Analysis, Ashraf Ahmed, Shaun Abid Md, Abhinav Aggarwal, Samdish Sethi, Ilia Ryzhkov, Nur Rahman Md, Assad Ur Rehman Md, Mohamed A. Badheeb, Isaac Opoku Md, Rasha Kaddoura, Rajvir Singh Md, Sandeep S. Nayak, Gilead Lancaster

Posters

Left ventricular thrombus (LVT) has been associated with an increased risk of cardioembolic stroke. However, it has not been established if coronary angiography (CAG) or percutaneous intervention (PCI) would enhance that risk. This study aims to determine the risk of cardioembolic stroke among patients with LVT who underwent CAG or PCI.

Thoughts From The Frontline - October 2024, Tennessee Center For Nursing Advancement, East Tennessee State University

Thoughts from the Frontline Newsletter

No abstract provided.

Seeding Belonging: Project Dig Short Report, Jeff Gutierrez, Connie Lewis, University Of Montana Rural Institute

Health and Wellness

This short report provides a snapshot of Project DIG, a therapeutic horticulture (TH) pilot project of the Rural Institute for Inclusive Communities. It contains information about and recommendations for TH as an increased practice for supporting and promoting the quality of life and well-being of people with intellectual and developmental disabilities.

Investigating Dual Task Balance Exercises: Quantifying Practice Patterns And Understanding Decision-Making Among Physical Therapists, Amelia Sabin, Wes Spagnuolo, Narissa Libby, Kylie Berry

Research Report Posters

Dual-task exercise has been shown to be an effective intervention to improve patient functional outcomes and decrease falls. However, little is known about whether physical therapists are prescribing dual task exercises during their sessions, or at what intensity. The objective of this research was to analyze differences and similarities of observed balance exercise practice patterns and reported practice and decision-making among physical therapists. We analyzed both quantitative and qualitative data from two separate studies and extracted data regarding dual-task balance exercises. Our analysis found that therapists rarely perform, describe, or report thinking about dual-task balance exercises in their physical therapy …

Correcting Misperceptions About Very Low Nicotine Cigarettes For Cigarette-Only Smokers, Dual/Poly Smokers, Other Tobacco Users, And Non-Tobacco Users, Rui Shi, Robert Feldman, Jiaying Liu, Pamela I. Clark

College of Communication & Creative Arts Departmental Research

Background

Methods

To Screen Or Not To Screen, That Is The Question, Saddam Zaidi Md, Cheng-Hung Tai, Caroline Loeser

Posters

AASLD and EASL recommend biennial HCC screening for Child-Pugh A and B, but not C. We report a 43-year-old female with alcohol related hepatitis and cirrhosis. Her Fibro test score improved from F4 in 2021 to F2 in 2023 with strict alcohol abstinence. AASLD guidelines for HCC screening in such cases remain unclear.

Cardiac Arrest Associated With Thyrotoxicosis: A Systematic Review, Ashraf Ahmed, Mohamed A. Badheeb, Shaun Abid Md, Douglas Webber, Samdish Sethi, Mayowa Adefuye, Deepak R. Vangipuram, Anda Gonciulea Md, Stuart Zarich, Gregory K. Buller

Posters

Thyrotoxicosis is a systemic condition caused by the effects of elevated levels of thyroid hormones. The cardiovascular manifestations of thyrotoxicosis range from sinus tachycardia and atrial fibrillation to heart failure. The incidence of malignant arrhythmias and cardiac arrest associated with thyrotoxicosis is not well known, and much of the current literature regarding this is limited to case reports. This study conducts a systematic review of the literature to identify patient demographics and outcomes where thyrotoxicosis manifests as cardiac arrest.

An Interesting Case Of Candida Tropicalis Endocarditis, Abbas Mallick Md, Farrah R. Khan Md, Sohrab Singh Md, Salman Ayaz Md, Prandeep Kumar Devarakonda Md, Iyad Al-Bustami Md

Posters

Infective Endocarditis (IE) is a disease characterized by microbe and fibrin rich complex adhesion to the cardiac valvular apparatus. Common culprit microorganisms include gram positive bacteria however valvular infections with fungal organisms are rare. We present an uncommon case of Candida Tropicalis endocarditis.

Revitalizing Engagement: Implementing Interactive Nurse Preceptor Development Training, Justine Hidalgo Msn, Rn, Cmsrn, Wcc, Mary Judson Msn, Rn, Ccrn, Cnl, Tiffany Torelli Msn, Rn, C-Efm, Katrina Williams Msn, Rn

Abstracts

Presentation at the 2025 CT Nursing Research Alliance Conference

Preceptor training is crucial for the development of nurse preceptors. An interactive in-person preceptor class was developed, incorporating learning strategies such as gaming and role play. After implementation of the class, results showed an increase in confidence among nurse preceptors and satisfaction with learning through various teaching methods.

Outcomes After Major Adverse Cardiovascular Events In Obese Versus Non-Obese Masld Patients: A Nationwide Inpatient Sample Study, Prince A. Ameyaw, Sarpong Boateng, Tawanda Zinyandu, Basile Njei, Ashraf Ahmed

Posters

MASLD is the most common etiology of chronic liver disease globally. MASLD is strongly associated with obesity and adverse cardiovascular outcomes. This study aims to investigate the outcomes after MACE in patients with obese versus non-obese MASLD.

A Rare Case Of Neuroleptic Malignant Syndrome, Farrah R. Khan Md, Salman Ayaz Md, Rasha Saleth Md, Aysha Rana Md, Bryan Schaf Md, Zahra Khan Md

Posters

This case highlights the importance of identifying the signs of NMS in patients who are on antipsychotics. Although it is an uncommon phenomenon, heightened awareness is important to prevent delays or worsening conditions.

Outcomes Of Alcohol-Associated Hepatitis In Hospitalized Patients With Prior Bariatric Surgery: A Nationwide Analysis, 2016-2020, Sarpong Boateng, Prince A. Ameyaw, Karthik Mathialagan, Basile Njei

Posters

Alcohol-associated hepatitis (AAH) is a severe liver condition often necessitating hospitalization and has a one-year mortality of 40%. The increasing prevalence of obesity has led to a rise in bariatric surgery (BS), which can alter the outcomes of various comorbid conditions. There are some concerns about possible increased risk and severity of alcohol related disorders in patients with a history of BS due to alteration in alcohol metabolism after surgery.