Medicine and Health Sciences Commons^™

Integrating Hypertension Detection And Management In Hiv Care In South Africa: Protocol For A Stepped-Wedged Cluster Randomized Effectiveness-Implementation Hybrid Trial, Karla I Galaviz, Charles W Goss, Aaloke Mody, Et Al.

2020-Current year OA Pubs

BACKGROUND: HIV clinical guidelines recommend hypertension detection and management to lower cardiovascular disease risk, but these have not been effectively implemented for people living with HIV (PWH). Addressing this implementation gap requires community-engaged implementation studies focused on addressing implementation barriers specific to the HIV care context.

METHODS: This protocol describes a type 2 effectiveness-implementation hybrid study conducted in nine primary care clinics in Johannesburg. The study will evaluate the effect of implementation strategies on guideline-recommended blood pressure assessment and management in HIV clinics and the effects of assessment/management on patient blood pressure. A stepped-wedge, cluster randomized study design was used …

Transjugular Random Renal Biopsy: A Review, Katelyn Gill, Dan F. Laney Iv, Hector Ferral

School of Medicine Faculty Publications

Random renal biopsy is considered the gold standard for the diagnosis of systemic renal disorders. Percutaneous biopsy remains a safe option for most patients; however, the percutaneous approach may be considered too risky in approximately 5-10% of patients. In these high-risk patients, transjugular renal biopsy (TJRB) may represent an underutilized alternative. TJRB is a technically difficult procedure with a learning curve of approximately 10 cases. When performed properly, TJRB is a safe alternative to percutaneous biopsy in patients with renal failure or who are at high risk of bleeding. This article aims to provide a comprehensive review of the indications, …

Clean Intermittent Catheterisation Determinants And Caregiver Adherence In Paediatric Patients With Spinal Dysraphism And Spinal Cord Injury In A Paediatric Spinal Differences Clinic: A Mixed Methods Study Protocol., Azadeh Wickham, Cynthia L. Russell, John Gatti

Manuscripts, Articles, Book Chapters and Other Papers

INTRODUCTION: Clean intermittent catheterisation (CIC) is the standard of care for treating neurogenic lower urinary tract dysfunction (NLUTD), the most common bladder dysfunction in children diagnosed with spinal dysraphism (SD) and spinal cord injury (SCI). Failure to follow the prescribed CIC regimen results in urinary tract infections, incontinence and renal insufficiency. Adherence to CIC is suboptimal, with reported non-adherence rates of 18%-66%. Despite the efficacy of CIC, the research on CIC adherence is not well defined in the literature and even less for caregivers of children on CIC protocols.

METHODS: This proposed study aims to identify caregiver CIC adherence and …

High-Sensitivity Cardiac Troponin [Hs-Ctn] As A Valuable Biomarker For Pulmonary Hypertension Risk Stratification: A Contemporary Review Of The Literature, Vijay Durga Pradeep Ganipineni, Sahas Reddy Jitta, Mohan Chandra Vinay Bharadwaj Gudiwada, Jaswanth Rao Jasti, Chaitra Janga, Bhavyasri Merugu, Revanth Reddy Bandaru, Srikanth Puli, Vikramaditya Samala Venkata, Advait Vasavada, Rupak Desai

Abington Jefferson Health Papers

Background: Pulmonary hypertension (PH) can lead to cardiac failure, thereby signif- icantly affecting life expectancy and quality of life. Due to inadequate disease surveillance and risk assessment, clinical challenges persist despite advances in diagnosis and treatment. We aimed to review the potential of high-sensitivity cardiac troponin (hs-cTn) as a biomarker for predicting outcomes in PH patients. Methods: A thorough examination of the PubMed and Google Scholar databases was conducted through March 2023. Studies involving adult PH patients and hsTn as a prognostic indicator of outcomes such as mortality, hospitalization, and disease progression were included, after screening their titles and abstracts. …

The Role Of Jordanian Television Programs In Raising Awareness About Mental Health From The Perspective Of Psychiatrists, Yasmine Hamza Badis, Saddam Suleiman Salman Almashaqbeh Dr

Middle East Journal of Communication Studies

The study aimed to identify the role of Jordanian television programs in raising awareness of mental health from the perspective of psychiatrists. The sample of the study was composed of 153 members from the Jordanian Association of Psychiatrists affiliated with the Jordanian Medical Association. To achieve the goal of this study, the descriptive approach was followed, and the study relied on the questionnaire as a tool for collecting data. The results of the study showed that the role of Jordanian television programs in raising awareness about mental health from the Perspective of psychiatrists was medium, and the diversity of features …

Effects Of Cadherin Mediated Contact Normalization On Oncogenic Src Kinase Mediated Gene Expression And Protein Phosphorylation, Rachel E Nicoletto, Cayla J Holdcraft, Ariel C Yin, Edward P Retzbach, Stephanie A Sheehan, Amanda A Greenspan, Christopher M Laugier, Jason Trama, Caifeng Zhao, Haiyan Zheng, Gary S Goldberg

Rowan-Virtua School of Osteopathic Medicine Departmental Research

Nontransformed cells form heterotypic cadherin junctions with adjacent transformed cells to inhibit tumor cell growth and motility. Transformed cells must override this form of growth control, called "contact normalization", to invade and metastasize during cancer progression. Heterocellular cadherin junctions between transformed and nontransformed cells are needed for this process. However, specific mechanisms downstream of cadherin signaling have not been clearly elucidated. Here, we utilized a β-catenin reporter construct to determine if contact normalization affects Wnt signaling in transformed cells. β-catenin driven GFP expression in Src transformed mouse embryonic cells was decreased when cultured with cadherin competent nontransformed cells compared to …

Directionality In Bicros Hearing Aids: An Investigation Of Objective And Subjective Outcomes, Hasan K. Saleh, Paula Folkeard, Volker Kuehnel, Solveig C. Voss, Jinyu Qian, Susan Scollie

Communication Sciences and Disorders Publications

Objectives: To assess the effect of forward and omnidirectional microphone configurations in BiCROS versus monaural hearing aids on objective and subjective outcomes in different noise conditions.

Design: After fitting and a 4-week acclimatisation period, speech recognition and sound quality were measured using forward directional, omnidirectional, and unaided settings. Two noise configurations were used, surrounding noise and noise presented from the aided (better) ear. Subjective outcomes were assessed using the SSQ-b and BBSS questionnaires and participant interviews.

Study sample: Eighteen adult participants (mean: 74.6 y; range: 61–94 y; ten males, eight females) with mild to moderately severe SNHL in their better …

Effect Of Covid-19 Vaccination On Covid-19 Mortality By Age In Georgia, Brennan Bogdanovich, Mckenzie E. Maloney, James Pollock, Lane Langston, Brittany Ange, Jack Yu

Journal of the Georgia Public Health Association

Purpose: The COVID-19 epidemic led to significant morbidity and mortality globally, especially among the elderly. Because SARS-CoV-2 is a novel viral pathogen, there was a lack of preventative and treatment options. Availability of effective vaccines has been an important factor in determining the epidemic trajectory. Analyzing the effects of the vaccines in reducing mortality across age groups is important for guiding future public health responses. The objective of this study was to determine the association between age and COVID-19 mortality pre- and post-vaccination periods amongst Georgians.

Methods: This cross-sectional study used COVID-19 case numbers, COVID-19 deaths, age at time of …

Barriers To Help-Seeking Behavior For Maternal Mental Health Disorders: Application Of The Health Belief Model, Tobi F. Oloyede, Joanne Chopak-Foss

Journal of the Georgia Public Health Association

Perinatal mood and anxiety disorders (PMADs) have become a leading cause of maternal mortality due to suicide among women in the first year following pregnancy. Although the profile for new mothers who die by suicide is predominantly white, disparities exist between Black and White women in their seeking help for perinatal and/or post-natal mood disorders. For Black, Indigenous, and People of Color (BIPOC), there are differences in the perceptions of the benefits of seeking help for PMADs. The COVID-19 pandemic exacerbated maternal mental health disorders in the United States particularly for women who live in communities with limited access to …

Bi-Directional Allosteric Pathway In Nmda Receptor Activation And Modulation, Paula A Bender, Subhajit Chakraborty, Ryan J Durham, Vladimir Berka, Elisa Carrillo, Vasanthi Jayaraman

Faculty, Staff and Student Publications

N-methyl-D-aspartate (NMDA) receptors are ionotropic glutamate receptors involved in learning and memory. NMDA receptors primarily comprise two GluN1 and two GluN2 subunits. The GluN2 subunit dictates biophysical receptor properties, including the extent of receptor activation and desensitization. GluN2A- and GluN2D-containing receptors represent two functional extremes. To uncover the conformational basis of their functional divergence, we utilize single-molecule fluorescence resonance energy transfer to probe the extracellular domains of these receptor subtypes under resting and ligand-bound conditions. We find that the conformational profile of the GluN2 amino-terminal domain correlates with the disparate functions of GluN2A- and GluN2D-containing receptors. Changes at the pre-transmembrane …

Stratomod: Predicting Sequencing And Variant Calling Errors With Interpretable Machine Learning, Nathan Dwarshuis, Peter Tonner, Nathan D Olson, Fritz J Sedlazeck, Justin Wagner, Justin M Zook

Faculty, Staff and Students Publications

Despite the variety in sequencing platforms, mappers, and variant callers, no single pipeline is optimal across the entire human genome. Therefore, developers, clinicians, and researchers need to make tradeoffs when designing pipelines for their application. Currently, assessing such tradeoffs relies on intuition about how a certain pipeline will perform in a given genomic context. We present StratoMod, which addresses this problem using an interpretable machine-learning classifier to predict germline variant calling errors in a data-driven manner. We show StratoMod can precisely predict recall using Hifi or Illumina and leverage StratoMod's interpretability to measure contributions from difficult-to-map and homopolymer regions for …

Examining Assessment Tools To Predict Burnout Among Healthcare Practitioners And Students, Robin Hilliard Albertson, Lindsay Gietzen

Pacific Journal of Health

The U.S. health system is stretched thin by pressures to expand service delivery and improve outcomes while reducing costs. This pressure is intensified by global health crises and other factors, resulting in further reductions in the healthcare workforce due to burnout. The strain leaves healthcare practitioners at risk of experiencing negative consequences of burnout, even death [1]. This study explored the correlations between three validated assessment tools to determine if early signs of burnout in healthcare practitioners and students can be identified succinctly, thus expanding the current body of evidence on the strengths of environments supporting career retention and healthcare …

Beyond The Checklist: Pilot Education, Aviation Resources, And Health Management Skills, Nancy Smith

Pacific Journal of Health

The research study investigates if pilots find aviation health-related materials provided from training or aviation associations to support their own health needs. A mixed methods convergent parallel design was conducted by sampling 27 pilots within general aviation to assess their utilization of aviation health-related materials, health management skills including self-efficacy and prioritization, as well as their views of implementing particular health topics into aviation training. Results of the study indicate that it is unclear if pilots find aviation health materials useful in managing their health, pilots have a relatively high level of self-efficacy and ability to prioritize one’s health and …

Navigating Artificial Intelligence In Spine Surgery: Implementation And Optimization Across The Care Continuum, Antony A. Fuleihan, Arjun K. Menta, Tej D. Azad, Kelly Jiang, Carly Weber-Levine, Daniel A. Davidar, Andrew M. Hersh, Nicholas Theodore

SKMC Student Presentations and Publications

The field of spine surgery has long been characterized by innovations and technological advancements. The integration of artificial intelligence (AI) into spine surgery represents one of the latest technical developments in the field. The ability of AI to rapidly analyze datasets improves decision making, risk assessment, intraoperative precision, and postoperative management, all of which contribute to increasing personalized spine care and improving outcomes. However, the successful implementation of AI faces regulatory and privacy challenges that must be addressed before its full potential can be realized. Here, we provide a detailed analysis of the current applications and future prospects of AI …

Thrombotic, Cardiovascular, And Microvascular Complications Of Myeloproliferative Neoplasms And Clonal Hematopoiesis (Chip): A Narrative Review, Andrew I Schafer, Douglas L Mann

2020-Current year OA Pubs

The most common causes of morbidity and mortality in the myeloproliferative neoplasms (MPNs), with the exception of myelofibrosis, are venous and arterial thrombosis, as well as more recently discovered cardiovascular disease (CVD). Clonal hematopoiesis of indeterminate potential (CHIP) is the subclinical finding in an individual of somatic mutations that are also found in clinically overt MPNs and other myeloid malignancies. The prevalence of "silent" CHIP increases with age. CHIP can transform into a clinically overt MPN at an estimated rate of 0.5 to 1% per year. It is likely, therefore, but not proven, that many, if not all, MPN patients …

Regular Nonsteroidal Anti-Inflammatory Drug Use Increases Stress Fracture Risk In The General Population: A Retrospective Case-Control Study, Alexandra Ciuciu, Chris Mulholland, Michael A. Bozzi, Chris C. Frymoyer, Leonardo Cavinatto, David Yaron, Marc I. Harwood, Jeremy D. Close, Christopher J. Mehallo, Ryan E. Tomlinson

Department of Orthopaedic Surgery Faculty Papers

Previous studies have shown that the use of nonsteroidal anti-inflammatory drugs (NSAIDs) is associated with increased stress fracture risk. This phenomenon has been studied predominantly in high-activity individuals, so data regarding the general population are limited despite the substantial economic and resource burden of stress fracture injuries within the general US population. Furthermore, our preclinical studies demonstrate that regular use of NSAIDs also diminishes the intrinsic ability of bone to resist fracture. To determine the association of regular NSAID use with stress fractures in the general population, we surveyed subjects presenting with either stress fracture or uncomplicated ankle sprain to …

Interleukin-1 Receptor-Associated Kinase 1 In Cancer Metastasis And Therapeutic Resistance: Mechanistic Insights And Translational Advances., Mariana K Najjar, Munazza S Khan, Chuling Zhuang, Ankush Chandra, Hui-Wen Lo

Faculty, Staff and Student Publications

Interleukin-1 Receptor Associated Kinase 1 (IRAK1) is a serine/threonine kinase that plays a critical role as a signaling transducer of the activated Toll-like receptor (TLR)/Interleukin-1 receptor (IL-1R) signaling pathway in both immune cells and cancer cells. Upon hyperphosphorylation by IRAK4, IRAK1 forms a complex with TRAF6, which results in the eventual activation of the NF-κB and MAPK pathways. IRAK1 can translocate to the nucleus where it phosphorylates STAT3 transcription factor, leading to enhanced IL-10 gene expression. In immune cells, activated IRAK1 coordinates innate immunity against pathogens and mediates inflammatory responses. In cancer cells, IRAK1 is frequently activated, and the activation …

Pain After Licorice Or Sugar-Water Gargling In Patients Recovering From Oropharyngeal Surgery-A Randomized, Double-Blind Trial, Marita Windpassinger, Michal Prusak, Jana Gemeiner, Olga Plattner, Stefan Janik, Gerold Besser, Wolfgang Gstoettner, Pu Xuan, Daniel I Sessler, Kurt Ruetzler

Faculty, Staff and Student Publications

Background: Glycyrrhiza glabrata (licorice) is used in traditional medicine and herbal remedies and reduces sore throats consequent to intubation, but whether it is protective for more intense pain after oropharyngeal surgery remains unclear. We thus tested the joint hypothesis that gargling with licorice, which has anti-inflammatory and antioxidant properties, reduces postoperative pain and morphine consumption.

Methods: We enrolled patients having elective oropharyngeal surgery. Participants were randomly allocated to gargle with either 1 g licorice or a sugar placebo before and for up to three days after surgery. A numerical rating scale (NRS) for pain along with morphine consumption was evaluated …

Sex Hormones And Risk Of Lung And Colorectal Cancers In Women: A Mendelian Randomization Study, Marion Denos, Yi-Qian Sun, Ben Michael Brumpton, Yafang Li, Demetrius Albanes, Andrea Burnett-Hartman, Peter T Campbell, Sébastien Küry, Christopher I Li, Emily White, Jewel N Samadder, Mark A Jenkins, Xiao-Mei Mai

Faculty, Staff and Students Publications

The roles of sex hormones such as estradiol, testosterone, and sex hormone-binding globulin (SHBG) in the etiology of lung and colorectal cancers in women, among the most common cancers after breast cancer, are unclear. This Mendelian randomization (MR) study evaluated such potential causal associations in women of European ancestry. We used summary statistics data from genome-wide association studies on sex hormones and from the Trøndelag Health Study (HUNT) and large consortia on cancers. There was suggestive evidence of 1-standard deviation increase in total testosterone levels being associated with a lower risk of lung non-adenocarcinoma (hazard ratio 0.60, 95% confidence interval …

A Proteomics Approach To Study Mouse Long Bones: Examining Baseline Differences And Mechanical Loading-Induced Bone Formation In Young-Adult And Old Mice, Christopher J Chermside-Scabbo, John T Shuster, Petra Erdmann-Gilmore, Eric Tycksen, Qiang Zhang, R Reid Townsend, Matthew J Silva

2020-Current year OA Pubs

With aging, bone mass declines and the anabolic effects of skeletal loading diminish. While much research has focused on gene transcription, how bone ages and loses its mechanoresponsiveness at the protein level remains unclear. We developed a novel proteomics approach and performed a paired mass spectrometry and RNA-seq analysis on tibias from young-adult (5-month) and old (22-month) mice. We report the first correlation estimate between the bone proteome and transcriptome (Spearman

Comparative Outcomes Of Transcatheter Versus Surgical Aortic Valve Replacement In Elderly Patients With Severe Symptomatic Aortic Stenosis: A Systematic Review, Omar Hamodat, Saif Almuzainy, Salma Nizar

Journal of the Saudi Heart Association

Objectives: Aortic stenosis is the most common valvular heart disease globally; while transcatheter aortic valve replacement (TAVR) has proven to be a competitive alternative to surgical aortic valve replacement (SAVR) and revolutionized treatment, its safety and efficacy has yet to be comprehensively assessed against SAVR for certain subsets of aortic stenosis patients; therefore, this study aims to systematically analyze all the available clinical evidence from randomized clinical trials on TAVR versus SAVR among intermediate and low-risk patients with severe symptomatic aortic stenosis.

Methodology: We performed a systematic review of the randomized controlled trials (RCT), studies comparing TAVR and …

The Price Of Prevention: Spain And Italy's Approach To National Prep, Jon Burkart

Claremont-UC Undergraduate Research Conference on the European Union

While recent advancements in antiretroviral therapy (ART) continue to improve the outlook for people living with HIV (PLHIV), new infections remain a concern for health authorities around the world. A clinically proven intervention holds the potential to dramatically reduce new infections: Pre-exposure prophylaxis (PrEP) is a once-daily pill for high-risk populations, including men who have sex with men (MSM), that substantially reduces HIV infection risk. However—much like rates of new infection—public provision of PrEP varies considerably among OECD countries. This case study thus seeks to answer the question: What might explain the disparate timeline of adopting public reimbursement for PrEP …

Genetic Knock-In Of Eif2ak3 Variants Reveals Differences In Perk Activity In Mouse Liver And Pancreas Under Endoplasmic Reticulum Stress, Shivesh Ghura, Noah R. Beratan, Xinglong Shi, Elena Alvarez-Periel, Sarah E. Bond Newton, Cagla Akay-Espinoza, Kelly L. Jordan-Sciutto

Farber Institute for Neuroscience Staff Papers and Presentations

Common single-nucleotide variants (SNVs) of eukaryotic translation initiation factor 2 alpha kinase 3 (EIF2AK3) slightly increase the risk of disorders in the periphery and the central nervous system. EIF2AK3 encodes protein kinase RNA-like endoplasmic reticulum kinase (PERK), a key regulator of ER stress. Three exonic EIF2AK3 SNVs form the PERK-B haplotype, which is present in 28% of the global population. Importantly, the precise impact of these SNVs on PERK activity remains elusive. In this study, we demonstrate that PERK-B SNVs do not alter PERK expression or basal activity in vitro and in the novel triple knock-in mice expressing the exonic …

Medical School Watercooler Newsletter - October 11, 2024, Lindsay Hughes

Watercooler Newsletter

This is the Friday, October 11, 2024 edition of the Frederick P. Whiddon College of Medicine's newsletter -- Watercooler.

Contents include:

• Furr elected board chair of the American Academy of Family Physicians
• Students and alumni invited to Dean's Tailgate Oct. 26
• Biomedical Library to host Creative Arts and Storytelling in Health and Wellness Summit
• Pediatrics residents share important health messages at area schools
• Medical student presents prostate cancer research at urology meeting
• J-1 training session scheduled for Oct. 18

Ventricular Interdependent Phenotype Of Mixed Cpc-Pulmonary Hypertension And Hfpef With Normal Left Atrium: Impact On Cpet Metrics And Clinical Outcome, Giovanna Zampierollo-Jaramillo, Anas Abed, Ahmed El Shaer, Mariana Garcia-Arango, Yimin Chen, Babak Tehrani, Wanxin Tu, Abdul Wahab Arif, Shannon Heffernan, Amir Esmaeeli, Aditya Sahai, James Runo, Sofia C. Masri, Farhan Raza

Division of Cardiology Faculty Papers

Among 45 CpcPH/heart failure with preserved ejection fraction participants, 11 with normal left atrium (compared to 34 with abnormal left atrium, p < 0.05 for all) had low left ventricle (LV) transmural pressure (2.9 ± 2.4 vs. 6.2 ± 2.9 mmHg), and increased right ventricle (RV):LV ratio (2.41 ± 1.09 vs. 1.46 ± 0.66) and interventricular septal angle (149 ± 8 vs. 136 ± 10), indicating exaggerated ventricular interdependence from a dilated RV

Fluid Biomarkers In The Context Of Amyloid-Targeting Disease-Modifying Treatments In Alzheimer's Disease, Yan Hu, Min Cho, Pallavi Sachdev, Jeffrey Dage, Suzanne Hendrix, Oskar Hansson, Randall J Bateman, Harald Hampel

2020-Current year OA Pubs

Clinical management and therapeutics development for Alzheimer's disease (AD) have entered a new era, with recent approvals of monoclonal antibody therapies targeting the underlying pathophysiology of the disease and modifying its trajectory. Imaging and fluid biomarkers are becoming increasingly important in the clinical development of AD therapeutics. This review focuses on the evidence of fluid biomarkers from recent amyloid-β-targeting clinical trials, summarizing biomarker data across 12 trials. It further proposes a simple framework to put biomarker guidance in the context of amyloid-pathway-targeted disease modification, delineates factors that impact biomarker data in clinical trials, and highlights knowledge gaps and future directions. …

Studying Contact Replays: Investigating Mechanisms, Management And Game Exposures (Scrimmage) For Brain Health In The Australasian National Rugby League: A Protocol For A Database Design, Andrew J. Gardner, Grant L. Iverson, Paul Bloomfield, Sharron Flahive, James Brown, Suzi Edwards, Gordon W. Fuller, Mazdak Ghajari, Prashant Jhala, Ben Jones, Christopher R. Levi, Warren Mcdonald, Shreya Mcleod, Cameron Owen, Georgia Page, Kenneth L. Quarrie, Oliver Smith, Peter Stanwell, Daniel Tadmor, Timana Tahu, Douglas P. Terry, Campbell Thomson, Ross Tucker, Lauren V. Fortington

Research outputs 2022 to 2026

Concussions in contact sports are challenging for athletes, health professionals and sporting bodies to prevent, detect and manage. Design of interventions for primary prevention, early recognition of concussion and continuing to improve postconcussion management are essential for protecting athletes and promoting brain health. Over the last decade, there have been advancements in video technology for analysing head impact events and improvements in the clinical management of concussions. This study protocol describes how researchers, clinicians and staff from the Australasian National Rugby League (NRL) have brought these advancements together and developed a database of videos with head impact events and clinical …

Factors Affecting The Quality Of Reporting Dispensing Errors Among Pharmacists, Kelley Latrece Lavallais

Walden Dissertations and Doctoral Studies

Medication dispensing errors, which are the inconsistency between the dispensing of medication to the patient against the prescribed medication, continue to be a public health challenge. Many studies have been conducted to examine their causes, including burnout, illegible handwriting, workload, and interruptions. There have also been studies on the types of medication dispensing errors. This study focused on the reporting of errors. The purpose of this quantitative study involving secondary data analysis was to examine the factors affecting the quality of reporting dispensing errors among pharmacists and the seriousness of the adverse events. The social-ecological model served as the theoretical …

Mates: A Deep Learning-Based Model For Locus-Specific Quantification Of Transposable Elements In Single Cell, Ruohan Wang, Yumin Zheng, Zijian Zhang, Kailu Song, Erxi Wu, Xiaopeng Zhu, Tao P Wu, Jun Ding

Faculty, Staff and Students Publications

Transposable elements (TEs) are crucial for genetic diversity and gene regulation. Current single-cell quantification methods often align multi-mapping reads to either 'best-mapped' or 'random-mapped' locations and categorize them at the subfamily levels, overlooking the biological necessity for accurate, locus-specific TE quantification. Moreover, these existing methods are primarily designed for and focused on transcriptomics data, which restricts their adaptability to single-cell data of other modalities. To address these challenges, here we introduce MATES, a deep-learning approach that accurately allocates multi-mapping reads to specific loci of TEs, utilizing context from adjacent read alignments flanking the TE locus. When applied to diverse single-cell …

Porous Iron Electrodes Reduce Energy Consumption During Electrocoagulation Of A Virus Surrogate: Insights Into Performance Enhancements Using Three-Dimensional Neutron Computed Tomography, Kyungho Kim, Cesar Castillo, Gyoung G Jang, Yuxuan Zhang, Costas Tsouris, Shankararaman Chellam

Faculty, Staff and Students Publications

Electrocoagulation has attracted significant attention as an alternative to conventional chemical coagulation because it is capable of removing a wide range of contaminants and has several potential advantages. In contrast to most electrocoagulation research that has been performed with nonporous electrodes, in this study, we demonstrate energy-efficient iron electrocoagulation using porous electrodes. In batch operation, investigation of the external pore structures through optical microscopy suggested that a low porosity electrode with sparse connection between pores may lead to mechanical failure of the pore network during electrolysis, whereas a high porosity electrode is vulnerable to pore clogging. Electrodes with intermediate porosity, …