Medicine and Health Sciences Commons^™

The Effect Of Different Types Of Phacoemulsification Surgery On The Postoperative Visual Acuity, Tarek Ibrahim Badr

Journal of Medicine in Scientific Research

Background

The most popular cataract surgery method in the world is phacoemulsification surgery. There are two kinds of phacoemulsification: longitudinal and torsional. Our research compares the impact of longitudinal and torsional phacoemulsification on postoperative visual acuity.

Patients and Methods

We will compare the postoperative best-corrected visual acuity (BCVA) after torsional phacoemulsification against longitudinal phacoemulsification in our prospective randomized trial. Fifty eyes having cataract of nuclear shape ranging in grade from grade 1 to grade 3 going to be involved in our study.

Results

Regarding postoperative visual acuity, the P-value between torsional phaco and longitudinal phaco was 0.557 (> 0.05), indicating …

The Effect Of The Primary Wound Closure Technique In The Surgical Treatment Of Closed Intra-Articular Calcaneal Fractures, Mohamed M. Abd El-Monem Gafar, Ashraf Hassen M. Mohammed, Ahmed A. Elseadawy, Mohamed Salah Labib

Journal of Medicine in Scientific Research

Aim: To assess the impact of the primary wound closure method in the surgical management of closed intra-articular calcaneal fractures, with the aim of improving postoperative wound healing, reducing complications, minimizing expenses, enhancing overall functional outcomes, and restoring foot function and patients' quality of life. Design: Our study, a prospective and retrospective cohort clinical study, was conducted in our hospitals. Patients and Methods: Twenty-eight patients with thirty-one intra-articular calcaneal fractures were enrolled, following stringent inclusion and exclusion criteria for patient selection. These patients underwent open reduction using an extensile lateral approach and internal fixation with plates and screws at our …

Clinical Study Of Combined Arthroscopic Drilling And Platelet Rich Plasma Injection In Knee Osteochondral Lesions In Middle-Aged Patients, Mohamed Salah Labib Mohamed, Mohamed Abd Elmoneam Gafar

Journal of Medicine in Scientific Research

Background: Osteochondral lesions commonly occur in the knee joints and causes detrimental effects on the quality of life. Arthroscopic drilling is the treatment option for mild to moderate lesions. However, it is debatable whether regenerated cartilage from arthroscopic drilling surgery is durable. It is speculated that induction of chondrocyte differentiation from subchondral mesenchymal stem cells is facilitated by platelet-rich plasma (PRP), which is a rich source of diverse growth factors.

Aim of work: To evaluate the procedures of combined arthroscopic drilling and PRP injection intra-articularly for mild to moderate knee osteochondral lesions management.

Patients and Methods: This randomized prospective study …

Short Term Effects Of Bariatric Surgeries On Renal And Hepatic Functions On Obese Morbid Patients, Naglaa F. Al-Mihy, Esayed Elmokadem, Atteyat Aboelmaged Semeya

Journal of Medicine in Scientific Research

Background: Bariatric surgery has emerged as a well-established treatment for achieving long-lasting and successful weight reduction. Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG) are currently the most frequently done operations. The aim of this research was to investigate the hepatic and renal alterations following bariatric procedures, with a particular focus on SG.

Methods: This observational prospective cohort research was performed on 100 morbidly obese individuals with BMI ≥40 kg/m² who underwent SG. All patients were evaluated before surgery clinically and all laboratory investigations were done before operation as baseline, 3 months, 6 months after surgery, and after one …

The Value Of Right Ventricular Systolic Function Assessment By 2d Speckle Tracking Echocardiography In Severe Ms, Alaa Ramadan Youssuf, Mohammad Morsy, Ibrahim Afifi, Mohamed Mansour, Eman H Seddik

Journal of Medicine in Scientific Research

Background: Many patients with long-standing mitral stenosis (MS) experience pulmonary hypertension (PH), which can eventually result in right heart failure. Several studies investigated the RV function changes in MS patients in the perioperative periods but focused on balloon mitral valvotomy (BMV). So our study aimed to assess the RV changes in severe MS patients planned for surgical mitral valve replacement (MVR).

Methods: A case-control study was carried out on severe MS patients planned for surgical MVR being unfit for BMV were subjected to conventional MS indices, RV Fractional area change (FAC), lateral tricuspid annular plane systolic excursion (TAPSE), RV global …

Mediastinal Packing For Massive Bleeding Following Acute Ascending Aortic Dissection Surgery: Outcomes And Risk Factors Analysis, Ahmed Shafeek Ali, Mostafa Abd Al Salam Mohamed Ghazi, Mahmoud Maher Abdou Ibrahim, Haitham Alshahat Ramadan

Journal of Medicine in Scientific Research

Background: Surgery for Acute Ascending Aortic Dissection (AAAD) is often complicated by severe perioperative coagulopathy and critical bleeding. Mediastinal packing is a widely recognised technique used to manage and control this complication. This retrospective study aims to analyze early outcomes and potential risk factors for patients subjected to mediastinal packing after AAAD surgery.

Methods: 352 consecutive patients who had undergone acute ascending aortic dissection (AAAD) surgery were studied at the National Heart Institution between February 2014 and Mars 2023. These patients were divided into two groups: the mediastinal packing with delayed closure group (n = 53; 15.05%) and …

Causes And Predictors Of Early 30-Day Rehospitalization After Isolated Elective Coronary Artery Bypass Surgery., Ahmed A Faragalla, Ahmed M Elshiemy, Sherif A Elhindawy, Ahmed A. Aziz

Journal of Medicine in Scientific Research

Background Despite advancements in interventional cardiology, CABG remains essential for many CAD patients. While surgical outcome scoring exists, early post-CABG re-hospitalization remains poorly understood.

Aim of the work This study investigates risk factors and underlying causes of 30-day readmission following elective isolated coronary artery bypass grafting (CABG).

Methods A prospective analysis of 550 consecutive elective isolated CABG patients at the National Heart Institute (January 2022 - June 2023) was undertaken to investigate the 30-day readmission rate, diagnoses, and independent predictors using a follow-up phone call strategy.

Results Analysis revealed a 2.9% (16/545) 30-day readmission rate. Surgical site infection was the …

Peroneal Artery Angioplasty As An Alternative For Limb Salvage In Patients With Critical Threatening Limb Ischemia, Mohamed Abdelsamie Abdelkhalek Elbahat, Mohamed Atef Almoslemany

Journal of Medicine in Scientific Research

Background: Chronic limb-threatening ischemia (CLTI) presents a significant health concern, particularly among patients with blockages in the lower leg arteries. Objectives: This prospective investigation aimed to evaluate the results of revascularization in CLTI patients, with particular attention to the peroneal artery as the preferred target vessel for limb salvage.

Materials and Methods: 50 CLTI patients were enrolled in the study and underwent thorough clinical evaluation, laboratory tests, and duplex scanning at regular intervals. Revascularization procedures, primarily using the antegrade femoral approach on the same side as the affected limb, involved balloon angioplasty. Postoperative outcomes were assessed based on the rates …

Safe Monsplasty Technique Combined With Abdominoplasty, Ebrahim Awad Rizk, Maurice Fekry Khalil

Journal of Medicine in Scientific Research

Background: One of the most common procedures for changing the shape of a person's body is abdominoplasty, which often includes monsplasty. It is one of the top five procedures in cosmetic surgery. Abdominoplasty and body lift operations may begin with a monsplasty. Here, we detail a novel method for treating pubic deformities triggered by massive weight reduction.

Aim and objectives; The purpose of this research was to evaluate how happy our patients were with the results of their monsplasty and abdominoplasty procedures following significant weight loss. Our team also tried to develop a surgical care decision-making system.

Subjects and methods; …

Adverse Pregnancy Outcomes Among Elderly Primigravida Women At Al-Galaa Maternity Teaching Hospital, Sherif M. Safwat, Marwa R. Shahin

Journal of Medicine in Scientific Research

Backgrounds: Pregnancy at advanced maternal age (AMA) is seen as a risk factor for poor maternal and perinatal outcomes. However, pregnancies with advanced maternal age have become more common in recent decades. This is attributable to increased employment options for women, a shift in gender norms, and improved reproductive medicine.

Objectives: Reviewing and assessment of the adverse pregnancy outcomes in elderly primigravida women compared to those with younger age.

Methodology: A case-control research study was conducted on patients who had attended for delivery at Al-Galaa Maternity Teaching Hospital during the period of one year from January 2022 to January 2023. …

Detection Of Cardiac Involvement Using Speckle Tracking Echocardiography In Covid-19 Recovered Patients And Its Relation To Leucocyte Count., Shaimaa Wageeh, Eman H Seddik, Alaa Ramadan Youssuf

Journal of Medicine in Scientific Research

Background: Globally, the coronavirus disease-2019 (COVID-19) pandemic remains a leading cause of morbidity and mortality. Our research aimed to assess the relationship between recovered COVID-19 patients' left ventricular (LV) systolic function and a range of inflammatory and hematological markers

Methods: For cases; baseline clinical and biochemical data such as the complete blood count (CBC), serum ferritin, C-reactive protein (CRP), lactate dehydrogenase (LDH), and D-dimer were measured Echocardiographic parameters of left ventricular (LV) functions, including global longitudinal strain (GLS), myocardial performance index (MPI), left atrial volume index (LAVI), and ejection fraction, were done to all cases and controls.

Results: GLS was …

The Value Of Neutrophil, Platelet-To-Lymphocyte Ratio And Lymphocyte To Monocyte Ratio With Disease Activity In Rheumatoid Arthritis, Lamis Safwat, Shaimaa Mohamed Abd El Aziz

Journal of Medicine in Scientific Research

For rheumatoid arthritis (RA) patients, altering their disease activity is crucial to their treatment plan. Utilising the platelet/lymphocyte ratio (PLR), neutrophil/lymphocyte ratio (NLR), and lymphocyte/monocyte ratio (LMR) as indicators of inflammation as a result of inflammatory process that led to alteration in platelets, neutrophils, monocytes, and lymphocytes absolute number. We aim to provide an overview of the most recent research on the diagnostic potential of three systemic inflammatory ratios as indicators of rheumatoid activity:), platelet/lymphocyte (PLR), neutrophil/lymphocyte (NLR) and lymphocyte/monocyte (LMR) . We concentrated on the research that evaluated blood cell parameters' diagnostic usefulness depending on the ROC ie area …

A Retro- Spective Cohort Study Of Acute Mesenteric Ischemia In Severe Coronavirus-19 Pneumonia At Shebin-Elkom Teaching Hospital, Talal Ibrahim Mostafa Hagag, Salwa Mohamed Ahmed Dahesh, Shimaa Mohamed Kalama

Journal of Medicine in Scientific Research

The purpose of this study was to examine the link between acute mesenteric ischemia and COVID-19 illness in terms of time to admission and intervention. Furthermore, the study focused on the critical time to admission for all patients of mesenteric occlusion. Methods: This study is a retrospective cohort conducted on 60 adults Patients with mesenteric occlusion were hospitalized to Shebein Elkom Teaching Hospital's Intensive Care Unit from March 2020 to September 30, 2022. The study involved two groups of mesenteric occlusion patients: 30 with proven covid19 and 30 without covid19. All medical histories, clinical and laboratory examinations, and the time …

Effect Of Yellow (577) Sub-Liminal Laser In Treatment Of Center Involved Macular Edema, Mohammed Shikhoun Ahmed, Eman Mohamed Etify, Tomas Nader Zakaria

Journal of Medicine in Scientific Research

Background: Advances in laser technology have led to the development of selective treatment without chorio-retinal damage. Subthreshold micropulse yellow laser has widespread benefits for the treatment of different macular disorders, as it allows the treatment of central macular edema without damage of photoreceptors or ganglion cell complex. Methods: Two hundred eyes of 120 patients with center involved mild to moderate macular edema attending at vitro-retinal unit/ ophthalmology department at Sohag Teaching Hospital were included. A pre-subliminal laser assessment of BCVA, CMT, and GCC was performed. Follow-up assessments were performed at one month, three months and six months post-laser treatment. Results: …

Effect Of Covid 19 On Pre-Existent Hypertension And Its Impact On Unmasking New Onset Hypertension In Recovered Cases: A Single Center Experience, Devang Kulkarni, Shital Patil, Anant Kulkarni, Gajanan Gondhali

Journal of Medicine in Scientific Research

Introduction New onset hypertension and aggravation of hypertension during the post-COVID period are issues of concern having very limited data published on them. Hence, the current study was conducted with the aim of studying the blood pressure profiles as new onset hypertension, preexistent hypertension and an aggravation of preexistent hypertension in post-COVID patients. Methods Retrospective cohort study conducted between October 2021 to March 2022, included 800 post-COVID patients above 18 years of age treated at the DCC (dedicated covid care center) irrespective of their disease severity and comorbidity after a valid written consent. All the study cases were followed after …

Evaluation Of Iron, Zinc And Vitamin D Deficiencies In Children With Autism Spectrum Disorder At The Hearing And Speech Institute, In Egypt, Azza Samy, Iman Elrouby, Eman S. Eldin, Eman S. Abd El-Ghaffar

Journal of Medicine in Scientific Research

Background Autism spectrum disorder (ASD) is a complex neurodevelopment disorder with a multifactorial etiology. Each iron, zinc and vitamin D are essential for cognitive, behavioral and motor development. Deficiency of any of these micronutrients may affect ASD symptoms.

Objective The aim of this study is to evaluate and compare the level of iron, zinc and vitamin D levels in children with autism spectrum disorder (ASD) with normal children and to associate between the deficiency of these nutrient elements and the severity of ASD symptoms, in order to help in improvement of ASD symptoms by supplying the deficient elements.

Patients and …

Inter-Reader Agreement And Accuracy Of O-Rads Mr Risk Stratification System In Assessment Of Adnexal Lesions, Mena Elerian Youssef Ekladious, Jehan Ibrahim M. Altohamy, Rania Hassan Mostafa Ahmed, Suzan Farouk Ibrahim Salib, Shrouk Mohamed Awadallah

Journal of Medicine in Scientific Research

Background Ultrasound is the initial modality employed to investigate adnexal lesions due to its high sensitivity and specificity in excluding malignancy when classic benign characteristics are observed. Nevertheless, the positive predictive value (PPV) of cancer can vary from 7% to 50% when a lesion has indeterminate imaging features in the US, and the PPV for cancer can range from 29% up to more than 50% when a lesion exhibits characteristics that are concerned for malignancy. (2). MRI has the capacity to enhance the PPV from cancer to 71%, with a negative predictive value of 98%. (3). The MRI's ability to …

Factors Affecting Non-Compliance With Treatment Among Diabetic Students At Sohag University, Rasha Gamal-El-Din Abu-El-Goud, Samah Wagdy Elkhayat, Ahmed Fathy Hamed, Seham Ahmed Abokresha

Journal of Medicine in Scientific Research

Background and objectives: Diabetes mellitus (DM) is a metabolic disease characterized by insufficient insulin synthesis, action, or both. Its prevalence is estimated to be alarmingly increasing. The aim of the study was studying factors influencing the non-compliance of diabetic students at Sohag University with treatment. Methods: Cross-sectional study at Sohag University for 7 months. Total number of diabetic students involved in the study was 153 students chosen from medical reports of administration of medical affairs in the university from May to November 2022; the participants who were studying in a scientific faculty were 51 (33.3%), and in Literary faculty were …

Design, Synthesis, Molecular Docking, And Molecular Dynamic Studies Of Novel Quinazoline Derivatives As Phosphodiesterase 7 Inhibitors, Marwa M. Safar Prof. Dr.

Pharmacy

Introduction: Phosphodiesterase 7 (PDE7) is a high-affinity cyclic AMP (cAMP)- specific PDE that is expressed in immune and proinflammatory cells. In this work, we explore the possibility that selective small molecule inhibitors of this enzyme family could provide a novel approach to alleviate the inflammation that is associated with many inflammatory diseases. Methods: A series of novel substituted 4-hydrazinoquinazoline derivatives and fused triazoloquinazolines were designed, synthesized, and evaluated in vitro for their PDE7A inhibition activities, in comparison with Theophylline, a non-selective PDE inhibitor, and BRL50481, a selective PDE7A inhibitor. This series of novel quinazoline derivatives were synthesized via multi-step reactions. …

In Silico Identifcation Of New Potential Inhibitors Of Quorum Sensing By Gram‑Positive Bacteria Through Specialized Molecular Docking, Amgad Albohy, Najla A. Obaid, Mariam Mojally, Mohammed Abou Rehab, Najd Ahmad Alkhudhir

Pharmacy

Quorum sensing is the process by which bacterial cells can communicate by producing substances to regulate viable processes such as gene expression, virulence, and bioflm formation. Gram-positive bacteria such as Staphylococcus aureus and Enterococcus faecalis have specifc enzymes (autoinducers) that control the quorum sensing system. Sortase A is a surface protein that regulates virulence and cell‒cell communication in Gram-positive bacteria. To interfere with this system and reduce virulence and cell‒cell communication, quorum sensing inhibitors are used, which are nonantibiotic substances. In this study, we aimed to use Food and Drug Administration-approved drugs (analgesics and antipsychotics) and investigate their activity using …

Design, Synthesis, And Anti-Mcf-7 Activity Of New Thieno[2,3-D]Pyrimidinone Derivatives As Potential Breast Cancer Treatment, Bassem H. Naguib, Amgad Albohy, Mostafa A. Abdelaziz, Hanan H. Kadry

Pharmacy

Breast cancer is one of the top leading causes of death and the most aggressive type of cancer in women. Resistance to chemotherapy is one of the challenges associated with the development of strategies for the treatment of breast cancer. One way to overcome this issue is to design new agents that target breast cancer cell lines such as MCF-7. In this study, a new series of S-alkylated thieno[2,3-d]pyrimidin-4-ones bearing carboxamide or ketonic scaffolds was synthesized and screened for their cytotoxicity against MCF-7 breast cell lines. Among synthesized candidates, 6d exhibited more potent cytotoxicity against MCF-7 cell lines with IC50 …

Development And Validation Of Green Stability-Indicating Rp-Hplc Method For Estimation Of Ertapenem: Degradation Kinetics And Structural Mass Elucidation Using Ms, Sohair M. Aboelghar, Hebatallah A. Wagdy, Maha A. Hegazy

Pharmacy

Ertapenem is an antibiotic that is used in the treatment of several bacterial infections, and it was recently approved for the treatment of the COVID-19 virus. A simple validated stability-indicating reversed phase High Performance Liquid Chromatographic (RP-HPLC) method was developed for ertapenem estimation. The separation was done using Pronto SIL® C18 (300 × 4.6 mm, 5 μm) as the stationary phase, methanol, and acidified water as the mobile phase in gradient mode with a flow rate of 1 mL/min and a pH 4.0 adjusted by orthophosphoric acid. The method was validated according to ICH guidelines. The linearity ranges from 5.00-120.00 …